Gadi Pelled, Margaux M Salas, Pei Han, Howard E Gill, Karl A Lautenschlager, Tristan T Lai, Cameron M Shawver, Matthew B Hoch, Brandon J Goff, Aaron M Betts, Zhengwei Zhou, Cody Lynch, Grant Schroeder, Maxim Bez, Marcel M Maya, Catherine Bresee, Zulma Gazit, John P McCallin, Dan Gazit, Debiao Li
Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients...
September 28, 2021: Scientific Reports