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https://www.readbyqxmd.com/read/29785947/-n-wasp-regulates-cortical-neuron-migration-through-its-polypro-and-vca-domains
#1
Xiu Lian Shen, Yi Chao Lu, Zhi Lian Jia, Qiang Wu
Cortical neuron migration in the developing mouse forebrain is a complex process, which contains several steps related to cytoskeleton dynamics and remodeling. Neural Wiskott-Aldrich syndrome protein (N-WASP), a member of the WASP-WAVE family, regulates actin cytoskeleton reorganization through the binding of its VCA domain to the Arp2/3 complex. Here we report expression patterns of N-WASP gene in the mouse developing embryonic cortex (E12.5~ E18.5) and find its expression levels are decreased during embryonic development...
May 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29773124/otolaryngology-and-the-global-burden-of-disease
#2
REVIEW
James E Saunders, Zane Rankin, Kathryn Y Noonan
The Global Burden of Disease (GBD) project provides longitudinal analysis of the global burden of otolaryngologic diseases by measuring the all-cause mortality, years of life lost, the years of life lived with disability, and disability-adjusted life years. Hearing loss burden is assessed overall and as sequelae of other diseases, such as otitis media or meningitis. Using these measures, we can appreciate the high prevalence and disability related to hearing loss globally. Other otolaryngologic diseases that contribute to the GBD include otitis media, cleft lip and palate, head and neck cancer, facial trauma, and oral disorders...
June 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29762765/global-epidemiology-and-burden-of-schizophrenia-findings-from-the-global-burden-of-disease-study-2016
#3
Fiona J Charlson, Alize J Ferrari, Damian F Santomauro, Sandra Diminic, Emily Stockings, James G Scott, John J McGrath, Harvey A Whiteford
Introduction: The global burden of disease (GBD) studies have derived detailed and comparable epidemiological and burden of disease estimates for schizophrenia. We report GBD 2016 estimates of schizophrenia prevalence and burden of disease with disaggregation by age, sex, year, and for all countries. Method: We conducted a systematic review to identify studies reporting the prevalence, incidence, remission, and/or excess mortality associated with schizophrenia. Reported estimates which met our inclusion criteria were entered into a Bayesian meta-regression tool used in GBD 2016 to derive prevalence for 20 age groups, 7 super-regions, 21 regions, and 195 countries and territories...
May 12, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29731809/out-of-alignment-limitations-of-the-global-burden-of-disease-in-assessing-the-allocation-of-global-health-aid
#4
Kristin Voigt, Nicholas B King
The Global Burden of Disease (GBD) project quantifies the impact of different health conditions by combining information about morbidity and premature mortality within a single metric, the Disability Adjusted Life Year. One important goal for the GBD project has been to inform decisions about global health priorities. A number of recent studies have used GBD data to argue that global health funding fails to align with the GBD. We argue that these studies' shared assumption that global health resources should 'align' with the burden of disease is unfounded and has troubling implications...
November 2017: Public Health Ethics
https://www.readbyqxmd.com/read/29705621/national-and-subnational-mortality-and-disability-adjusted-life-years-dalys-attributable-to-17-occupational-risk-factors-in-iran-1990-2015
#5
Mehrnoosh Abtahi, Ali Koolivand, Sina Dobaradaran, Kamyar Yaghmaeian, Shokooh Sadat Khaloo, Sahand Jorfi, Saeed Keshmiri, Amir Hossein Nafez, Reza Saeedi
We estimated age-sex specific and cause-specific mortality, years of life lost due to premature mortality (YLLs), years lived with disability (YLDs) and disability-adjusted life years (DALYs) attributable to 17 individual occupational risks in Iran at the national and subnational levels in 1990-2015 based on the Global Burden of Disease Study 2015 (GBD 2015). The burden of disease attributable to occupational risk factors was calculated using the comparative risk assessment methodology based on 10 outcomes and 21 risk-outcome pairs...
April 26, 2018: Environmental Research
https://www.readbyqxmd.com/read/29699588/burden-of-disease-attributable-to-suboptimal-diet-metabolic-risks-and-low-physical-activity-in-ethiopia-and-comparison-with-eastern-sub-saharan-african-countries-1990-2015-findings-from-the-global-burden-of-disease-study-2015
#6
Yohannes Adama Melaku, Molla Mesele Wassie, Tiffany K Gill, Shao Jia Zhou, Gizachew Assefa Tessema, Azmeraw T Amare, Yihunie Lakew, Abiy Hiruye, Tesfaye Hailu Bekele, Amare Worku, Oumer Seid, Kedir Endris, Ferew Lemma, Fisaha Haile Tesfay, Biruck Desalegn Yirsaw, Kebede Deribe, Robert Adams, Zumin Shi, Awoke Misganaw, Amare Deribew
BACKGROUND: Twelve of the 17 Sustainable Development Goals (SDGs) are related to malnutrition (both under- and overnutrition), other behavioral, and metabolic risk factors. However, comparative evidence on the impact of behavioral and metabolic risk factors on disease burden is limited in sub-Saharan Africa (SSA), including Ethiopia. Using data from the Global Burden of Disease (GBD) Study, we assessed mortality and disability-adjusted life years (DALYs) attributable to child and maternal undernutrition (CMU), dietary risks, metabolic risks and low physical activity for Ethiopia...
April 25, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29697771/burden-of-disease-studies-in-the-who-european-region-a-mapping-exercise
#7
Mark R O'Donovan, Christian Gapp, Claudia Stein
Background: The World Health Organization (WHO) and the Institute for Health Metrics and Evaluation (IHME) have produced numerous global burden of disease (GBD) estimates since the 1990s, using disability-adjusted life-years (DALYs). Here we attempt to identify studies that have either independent DALY estimates or build on the work of WHO and IHME, for the WHO European Region, categorize them by scope of disease analysis and geographic coverage, and briefly compare their methodology (age weighting, discounting and disability weights)...
April 25, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29692089/-effects-of-elevated-ozone-concentrations-on-reactive-oxygen-metabolism-and-related-gene-expression-in-ginkgo-biloba-leaves
#8
Ya Nan Ruan, Sheng Xu, Long Guo, Ming Zhu Zhu, Cong Wang, Shu Yuan Li, Hong Yan Wang
By using the open top chambers (OTCs) fumigation method, this paper investigated the changes of foliar injury, level of reactive oxygen species (ROS), activities and gene expression of antioxidant enzymes in Ginkgo biloba leaves under different ozone (ambient ozone≈40, 80, 160, 200 nmol·mol-1 ) concentrations, in order to study the effects of elevated ozone (O3 ) concentrations on reactive metabolism. The results showed that the obvious foliar injuries were observed in 160 and 200 nmol·mol-1 O3 treatments, while no visible injury was observed in 80 nmol·mol-1 O3 and ambient O3 treatments...
November 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29682005/global-burden-of-mental-disorders-among-children-aged-5-14-years
#9
Marie Laure Baranne, Bruno Falissard
Background: The global burden of disease (GBD) study provides information about fatal and non-fatal health outcomes around the world. Methods: The objective of this work is to describe the burden of mental disorders among children aged 5-14 years in each of the six regions of the World Health Organisation. Data come from the GBD 2015 study. Outcomes: disability-adjusted life-years (DALYs) are the main indicator of GBD studies and are built from years of life lost (YLLs) and years of life lived with disability (YLDs)...
2018: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/29664972/the-impact-of-social-and-psychological-consequences-of-disease-on-judgments-of-disease-severity-an-experimental-study
#10
Nicholas B King, Sam Harper, Meredith Young, Sarah C Berry, Kristin Voigt
BACKGROUND: The Global Burden of Disease (GBD) project systematically assesses mortality, healthy life expectancy, and disability across 195 countries and territories, using the disability-adjusted life year (DALY). Disability weights in the DALY are based upon surveys that ask users to rate health states based on lay descriptions. We conducted an experimental study to examine whether the inclusion or removal of psychological, social, or familial implications from a health state description might affect individual judgments about disease severity, and thus relative disability weights...
2018: PloS One
https://www.readbyqxmd.com/read/29659841/incidence-and-mortality-from-adverse-effects-of-medical-treatment-in-the-uk-1990-2013-levels-trends-patterns-and-comparisons
#11
Raimundas Lunevicius, Juanita A Haagsma
Objective: To present an update on incidence and mortality from adverse effects (AEs) of medical treatment in the UK, its four countries and nine English regions between 1990 and 2013. Design: Descriptive epidemiological study on AEs of medical treatment. AEs are shown as a single cause-of-injury category from the Global Burden of Disease (GBD) 2013 study. Data sources: The GBD 2013 interactive data visualisation tools 'Epi Visualisation' and 'GBD Compare'...
April 12, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29652030/endoscopic-ultrasound-guided-gallbladder-drainage-results-of-long-term-follow-up
#12
Omar Ahmed, Takeshi Ogura, Ali Eldahrouty, Hanaa Khalaf, Ehab Mohammed, Hussein Okasha, Ayat Sameer, Usama Abdelaal, Kazuhide Higuchi
Background/Aim: Recently, endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) has emerged using a self-expandable metallic stent (SEMS). The aim of the study was to evaluate the long-term outcomes of this procedure. In addition, the efficacy and safety of EUS-GBD with SEMS were assessed. Patients and Methods: Thirteen consecutive patients who underwent EUS-GBD for acute cholecystitis between February 2014 and September 2016 were included in this retrospective study...
April 13, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29619948/gairdner-awards-2018-honour-gbd-studies
#13
Brian Owens
No abstract text is available yet for this article.
March 31, 2018: Lancet
https://www.readbyqxmd.com/read/29577030/eus-guided-gall-bladder-drainage-in-severe-liver-disease-a-single-center-experience-in-critically-ill-cirrhotics
#14
Kapil Dev Jamwal, Manoj Kumar Sharma, Rakhi Maiwall, Barjesh Kumar Sharma, Shiv Kumar Sarin
Background and Aims : Acute calculous cholecystitis with impending gall bladder perforation in severe liver diseases including decompensated cirrhosis and acute-on-chronic liver failure (ACLF) is difficult to manage, due to the procedures such as cholecystectomy and per cutaneous cholecystostomy being associated with high risk and complications in these patients. Methods : Four cases of severe liver disease with acute calculous cholecystitis who presented to the Institute of Liver and Biliary Sciences (New Delhi, India) for further management were included in the study if they underwent endoscopic ultrasound-guided gall bladder drainage (EUS-GBD)...
March 28, 2018: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29567645/ptrn-1-camsap-promotes-cyk-1-formin-dependent-actin-polymerization-during-endocytic-recycling
#15
Ting Gong, Yanling Yan, Jing Zhang, Shuai Liu, Hang Liu, Jinghu Gao, Xin Zhou, Juan Chen, Anbing Shi
Cargo sorting and membrane carrier initiation in recycling endosomes require appropriately coordinated actin dynamics. However, the mechanism underlying the regulation of actin organization during recycling transport remains elusive. Here we report that the loss of PTRN-1/CAMSAP stalled actin exchange and diminished the cytosolic actin structures. Furthermore, we found that PTRN-1 is required for the recycling of clathrin-independent cargo hTAC-GFP The N-terminal calponin homology (CH) domain and central coiled-coils (CC) region of PTRN-1 can synergistically sustain the flow of hTAC-GFP We identified CYK-1/formin as a binding partner of PTRN-1...
May 2, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29557048/the-burden-of-cardiovascular-disease-in-sub-saharan-africa-and-the-black-diaspora
#16
Richard F Gillum
For over four decades the National Medical Association (NMA) and the Association of Black Cardiologists (ABC) have sought to bring to national attention the disparate burden of cardiovascular disease (CVD) among African Americans. However, systematic inquiry has been inadequate into the burden of CVD in the poor countries of Sub-Saharan Africa (SSA) and the African diaspora in the Americas outside the USA. However, recently, the Global Burden of Disease Study (GBD) has offered new tools for such inquiry. Several initial efforts in that direction using 2010 data have been published...
March 19, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29553421/the-relation-between-health-research-output-and-burden-of-disease-in-palestine-a-systematic-review
#17
Loai Albarqouni, Khamis Elessi, Niveen Abu-Rmeileh
BACKGROUND: Highest priority should be given to research on conditions responsible for the greatest disease burden. This is particularly important in settings where resources are scarce. The aim of this study was to assess the association between research output and disease burden in the occupied Palestinian territory and to identify the conditions that are under-investigated or over-investigated, if any. METHODS: We searched PubMed and Scopus for reports of original research relevant to human health or health care that was authored by researchers affiliated with Palestinian institutions and published between Jan 1, 2000, and Dec 31, 2015...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29544498/a-comparison-between-health-research-output-and-burden-of-disease-in-arab-countries-evidence-from-palestine
#18
Loai Albarqouni, Khamis Elessi, Niveen M E Abu-Rmeileh
BACKGROUND: Research conducted on conditions responsible for the greatest disease burden should be given the highest priority, particularly in resource-limited settings. The present study aimed to assess the research output in relation to disease burden in Palestine and to identify the conditions which are under- or over-investigated, if any. METHODS: We searched PubMed and Scopus for reports of original research relevant to human health or healthcare authored by researchers affiliated with Palestinian institutions and published between January 2000 and December 2015...
March 15, 2018: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29516222/burden-and-trend-of-diet-related-non-communicable-diseases-in-australia-and-comparison-with-34-oecd-countries-1990-2015-findings-from-the-global-burden-of-disease-study-2015
#19
Yohannes Adama Melaku, Andre Renzaho, Tiffany K Gill, Anne W Taylor, Eleonora Dal Grande, Barbora de Courten, Estifanos Baye, David Gonzalez-Chica, Elina Hyppӧnen, Zumin Shi, Malcolm Riley, Robert Adams, Yohannes Kinfu
BACKGROUND: Diet is a major determining factor for many non-communicable chronic diseases (NCDs). However, evidence on diet-related NCD burden remains limited. We assessed the trends in diet-related NCDs in Australia from 1990 to 2015 and compared the results with other countries of the Organization for Economic Co-operation and Development (OECD). METHODS: We used data and methods from the Global Burden of Disease (GBD) 2015 study to estimate the NCD mortality and disability-adjusted life years (DALYs) attributable to 14 dietary risk factors in Australia and 34 OECD nations...
March 7, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29480409/the-global-spine-care-initiative-a-summary-of-the-global-burden-of-low-back-and-neck-pain-studies
#20
REVIEW
Eric L Hurwitz, Kristi Randhawa, Hainan Yu, Pierre Côté, Scott Haldeman
PURPOSE: This article summarizes relevant findings related to low back and neck pain from the Global Burden of Disease (GBD) reports for the purpose of informing the Global Spine Care Initiative. METHODS: We reviewed and summarized back and neck pain burden data from two studies that were published in Lancet in 2016, namely: "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015" and "Global, regional, and national disability-adjusted life years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015...
February 26, 2018: European Spine Journal
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