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https://www.readbyqxmd.com/read/28808642/burden-of-disease-attributable-to-vitamin-a-deficiency-in-iranian-population-aged-less-than-five-years-findings-from-the-global-burden-of-disease-study-2010
#1
Maryam Bahreynian, Mostafa Qorbani, Shohreh Naderimagham, Sara Nejatinamini, Asal Ataie-Jafari, Farshad Sharifi, Fahad Saqib, Alireza Khajavi, Morteza Mansourian, Ali Asghar Ahmadishokouh, Hamid Asayesh, Omid Safari, Roya Kelishadi
BACKGROUND: Vitamin A deficiency (VAD) is considered as one of the most serious public health concerns in developing countriesand the leading cause of mortality in under-five-year-old children.A large number of young children and pregnant women especially in low-income, non-industrialized communities are more susceptible to VAD. This study aims to report the burden of disease (BOD) attributable to VAD in Iranian population aged less than 5 years by using data of the Global Burden of Disease (GBD) study 2010...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28805312/the-dock-and-coalesce-mechanism-for-the-association-of-a-wasp-disordered-region-with-the-cdc42-gtpase
#2
Li Ou, Megan Matthews, Xiaodong Pang, Huan-Xiang Zhou
Intrinsically disordered proteins (IDPs) play key roles in signaling and regulation. Many IDPs undergo folding upon binding to their targets. We have proposed that coupled folding and binding of IDPs generally follow a dock-and-coalesce mechanism, whereby a segment of the IDP, through diffusion, docks to its cognate subsite and, subsequently, the remaining segments coalesce around their subsites. Here, by a combination of experiment and computation, we determined the precise form of dock-and-coalesce operating in the association between the intrinsically disordered GTPase binding domain (GBD) of the Wiskott-Aldrich Syndrome protein (WASP) and the Cdc42 GTPase...
August 14, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28792274/global-regional-and-national-prevalence-incidence-and-disability-adjusted-life-years-for-oral-conditions-for-195-countries-1990-2015-a-systematic-analysis-for-the-global-burden-of-diseases-injuries-and-risk-factors
#3
N J Kassebaum, A G C Smith, E Bernabé, T D Fleming, A E Reynolds, T Vos, C J L Murray, W Marcenes
The Global Burden of Disease 2015 study aims to use all available data of sufficient quality to generate reliable and valid prevalence, incidence, and disability-adjusted life year (DALY) estimates of oral conditions for the period of 1990 to 2015. Since death as a direct result of oral diseases is rare, DALY estimates were based on years lived with disability, which are estimated only on those persons with unmet need for dental care. We used our data to assess progress toward the Federation Dental International, World Health Organization, and International Association for Dental Research's oral health goals of reducing the level of oral diseases and minimizing their impact by 2020...
April 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28780818/-exploratory-analysis-on-burden-of-disease-attributable-to-asbestosis-from-2006-to-2015
#4
M X Liu, X J Zhu, T Li, P Xiao, D Wang
Objective: To analyze the levels and trends of the burden of disease attributable to asbestosis from 2006 to 2015. Methods: Theincidence of asbestosis from 2006 to 2015 was used for calculation, with data of disability weight and remission rate from Global burden of disease study 2015 (GBD 2015) and DisMoD-MR 2.1 software for the calculation of duration and age of year onset. The reference template of GBD was adopted to calculate disability adjusted life year (DALY) , year of life lost (YLL) and year of lived with disability (YLD) value in order to analyze the level and changing trend of burden of disease attributable to asbestosis...
June 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28778040/health-impacts-related-to-urban-and-transport-planning-a-burden-of-disease-assessment
#5
Natalie Mueller, David Rojas-Rueda, Xavier Basagaña, Marta Cirach, Tom Cole-Hunter, Payam Dadvand, David Donaire-Gonzalez, Maria Foraster, Mireia Gascon, David Martinez, Cathryn Tonne, Margarita Triguero-Mas, Antònia Valentín, Mark Nieuwenhuijsen
INTRODUCTION: Until now, estimates of the Global Burden of Disease (GBD) have mainly been produced on national or regional levels. These general estimates, however, are less useful for city governments who have to take decisions on local scales. To address this gap, we focused on the city-level burden of disease (BD) due to exposures affected by urban and transport planning. We conducted a BD assessment using the Urban and Transport Planning Health Impact Assessment (UTOPHIA) tool to estimate annual preventable morbidity and disability-adjusted life-years (DALYs) under compliance with international exposure recommendations for physical activity (PA), exposure to air pollution, noise, heat, and access to green spaces in Barcelona, Spain...
October 2017: Environment International
https://www.readbyqxmd.com/read/28776255/transport-injuries-and-deaths-in-the-eastern-mediterranean-region-findings-from-the-global-burden-of-disease-2015-study
#6
Ali H Mokdad
OBJECTIVES: Transport injuries (TI) are ranked as one of the leading causes of death, disability, and property loss worldwide. This paper provides an overview of the burden of TI in the Eastern Mediterranean Region (EMR) by age and sex from 1990 to 2015. METHODS: Transport injuries mortality in the EMR was estimated using the Global Burden of Disease mortality database, with corrections for ill-defined causes of death, using the cause of death ensemble modeling tool...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776254/burden-of-cancer-in-the-eastern-mediterranean-region-2005-2015-findings-from-the-global-burden-of-disease-2015-study
#7
Christina Fitzmaurice
OBJECTIVES: To estimate incidence, mortality, and disability-adjusted life years (DALYs) caused by cancer in the Eastern Mediterranean Region (EMR) between 2005 and 2015. METHODS: Vital registration system and cancer registry data from the EMR region were analyzed for 29 cancer groups in 22 EMR countries using the Global Burden of Disease Study 2015 methodology. RESULTS: In 2015, cancer was responsible for 9.4% of all deaths and 5.1% of all DALYs...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776253/adolescent-health-in-the-eastern-mediterranean-region-findings-from-the-global-burden-of-disease-2015-study
#8
Ali H Mokdad
OBJECTIVES: The 22 countries of the East Mediterranean Region (EMR) have large populations of adolescents aged 10-24 years. These adolescents are central to assuring the health, development, and peace of this region. We described their health needs. METHODS: Using data from the Global Burden of Disease Study 2015 (GBD 2015), we report the leading causes of mortality and morbidity for adolescents in the EMR from 1990 to 2015. We also report the prevalence of key health risk behaviors and determinants...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776252/maternal-mortality-and-morbidity-burden-in-the-eastern-mediterranean-region-findings-from-the-global-burden-of-disease-2015-study
#9
Ali H Mokdad
OBJECTIVES: Assessing the burden of maternal mortality is important for tracking progress and identifying public health gaps. This paper provides an overview of the burden of maternal mortality in the Eastern Mediterranean Region (EMR) by underlying cause and age from 1990 to 2015. METHODS: We used the results of the Global Burden of Disease 2015 study to explore maternal mortality in the EMR countries. RESULTS: The maternal mortality ratio in the EMR decreased 16...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776251/intentional-injuries-in-the-eastern-mediterranean-region-1990-2015-findings-from-the-global-burden-of-disease-2015-study
#10
Ali H Mokdad
OBJECTIVES: We used GBD 2015 findings to measure the burden of intentional injuries in the Eastern Mediterranean Region (EMR) between 1990 and 2015. METHODS: The Global Burden of Disease (GBD) study defines intentional injuries as a combination of self-harm (including suicide), interpersonal violence, collective violence (war), and legal intervention. We estimated number of deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) for each type of intentional injuries...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776250/burden-of-vision-loss-in-the-eastern-mediterranean-region-1990-2015-findings-from-the-global-burden-of-disease-2015-study
#11
Ali H Mokdad
OBJECTIVES: To report the estimated trend in prevalence and years lived with disability (YLDs) due to vision loss (VL) in the Eastern Mediterranean region (EMR) from 1990 to 2015. METHODS: The estimated trends in age-standardized prevalence and the YLDs rate due to VL in 22 EMR countries were extracted from the Global Burden of Disease (GBD) 2015 study. The association of Socio-demographic Index (SDI) with changes in prevalence and YLDs of VL was evaluated using a multilevel mixed model...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776249/trends-in-hiv-aids-morbidity-and-mortality-in-eastern-mediterranean-countries-1990-2015-findings-from-the-global-burden-of-disease-2015-study
#12
Ali H Mokdad
OBJECTIVES: We used the results of the Global Burden of Disease 2015 study to estimate trends of HIV/AIDS burden in Eastern Mediterranean Region (EMR) countries between 1990 and 2015. METHODS: Tailored estimation methods were used to produce final estimates of mortality. Years of life lost (YLLs) were calculated by multiplying the mortality rate by population by age-specific life expectancy. Years lived with disability (YLDs) were computed as the prevalence of a sequela multiplied by its disability weight...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776247/the-burden-of-mental-disorders-in-the-eastern-mediterranean-region-1990-2015-findings-from-the-global-burden-of-disease-2015-study
#13
Ali H Mokdad
OBJECTIVES: Mental disorders are among the leading causes of nonfatal burden of disease globally. METHODS: We used the global burden of diseases, injuries, and risk factors study 2015 to examine the burden of mental disorders in the Eastern Mediterranean region (EMR). We defined mental disorders according to criteria proposed in the diagnostic and statistical manual of mental disorders IV and the 10th International Classification of Diseases. RESULTS: Mental disorders contributed to 4...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776246/burden-of-lower-respiratory-infections-in-the-eastern-mediterranean-region-between-1990-and-2015-findings-from-the-global-burden-of-disease-2015-study
#14
Ali H Mokdad
OBJECTIVES: We used data from the Global Burden of Disease 2015 study (GBD) to calculate the burden of lower respiratory infections (LRIs) in the 22 countries of the Eastern Mediterranean Region (EMR) from 1990 to 2015. METHODS: We conducted a systematic analysis of mortality and morbidity data for LRI and its specific etiologic factors, including pneumococcus, Haemophilus influenzae type b, Respiratory syncytial virus, and influenza virus. We used modeling methods to estimate incidence, deaths, and disability-adjusted life-years (DALYs)...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776245/burden-of-cardiovascular-diseases-in-the-eastern-mediterranean-region-1990-2015-findings-from-the-global-burden-of-disease-2015-study
#15
Ali H Mokdad
OBJECTIVES: To report the burden of cardiovascular diseases (CVD) in the Eastern Mediterranean Region (EMR) during 1990-2015. METHODS: We used the 2015 Global Burden of Disease study for estimates of mortality and disability-adjusted life years (DALYs) of different CVD in 22 countries of EMR. RESULTS: A total of 1.4 million CVD deaths (95% UI: 1.3-1.5) occurred in 2015 in the EMR, with the highest number of deaths in Pakistan (465,116) and the lowest number of deaths in Qatar (723)...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776243/burden-of-obesity-in-the-eastern-mediterranean-region-findings-from-the-global-burden-of-disease-2015-study
#16
Ali H Mokdad
OBJECTIVES: We used the Global Burden of Disease (GBD) 2015 study results to explore the burden of high body mass index (BMI) in the Eastern Mediterranean Region (EMR). METHODS: We estimated the prevalence of overweight and obesity among children (2-19 years) and adults (≥20 years) in 1980 and 2015. The burden of disease related to high BMI was calculated using the GBD comparative risk assessment approach. RESULTS: The prevalence of obesity increased for adults from 15...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776242/neonatal-infant-and-under-5-mortality-and-morbidity-burden-in-the-eastern-mediterranean-region-findings-from-the-global-burden-of-disease-2015-study
#17
Ali H Mokdad
OBJECTIVES: Although substantial reductions in under-5 mortality have been observed during the past 35 years, progress in the Eastern Mediterranean Region (EMR) has been uneven. This paper provides an overview of child mortality and morbidity in the EMR based on the Global Burden of Disease (GBD) study. METHODS: We used GBD 2015 study results to explore under-5 mortality and morbidity in EMR countries. RESULTS: In 2015, 755,844 (95% uncertainty interval (UI) 712,064-801,565) children under 5 died in the EMR...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776240/diabetes-mellitus-and-chronic-kidney-disease-in-the-eastern-mediterranean-region-findings-from-the-global-burden-of-disease-2015-study
#18
Ali H Mokdad
OBJECTIVES: We used findings from the Global Burden of Disease 2015 study to update our previous publication on the burden of diabetes and chronic kidney disease due to diabetes (CKD-DM) during 1990-2015. METHODS: We extracted GBD 2015 estimates for prevalence, mortality, and disability-adjusted life years (DALYs) of diabetes (including burden of low vision due to diabetes, neuropathy, and amputations and CKD-DM for 22 countries of the EMR from the GBD visualization tools...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776239/burden-of-diarrhea-in-the-eastern-mediterranean-region-1990-2015-findings-from-the-global-burden-of-disease-2015-study
#19
Ali H Mokdad
OBJECTIVES: Diarrheal diseases (DD) are an important cause of disease burden, especially in children in low-income settings. DD can also impact children's potential livelihood through growth faltering, cognitive impairment, and other sequelae. METHODS: As part of the Global Burden of Disease study, we estimated DD burden, and the burden attributable to specific risk factors and etiologies, in the Eastern Mediterranean Region (EMR) between 1990 and 2015. We calculated disability-adjusted life-years (DALYs)-the sum of years of life lost and years lived with disability-for both sexes and all ages...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776238/danger-ahead-the-burden-of-diseases-injuries-and-risk-factors-in-the-eastern-mediterranean-region-1990-2015
#20
Ali H Mokdad
OBJECTIVES: The Eastern Mediterranean Region faces several health challenges at a difficult time with wars, unrest, and economic change. METHODS: We used the Global Burden of Disease 2015 study to present the burden of diseases, injuries, and risk factors in the Eastern Mediterranean Region from 1990 to 2015. RESULTS: Ischemic heart disease was the leading cause of death in the region in 2015, followed by cerebrovascular disease. Changes in total deaths ranged from a reduction of 25% for diarrheal diseases to an increase of about 42% for diabetes and tracheal, bronchus, and lung cancer...
August 3, 2017: International Journal of Public Health
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