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https://www.readbyqxmd.com/read/28528201/x-linked-carriers-of-chronic-granulomatous-disease-illness-lyonization-and-stability
#1
Beatriz E Marciano, Christa S Zerbe, E Liana Falcone, Li Ding, Suk See DeRavin, Janine Daub, Samantha Kreuzburg, Lynne Yockey, Sally Hunsberger, Ladan Foruraghi, Lisa A Barnhart, Kabir Matharu, Victoria Anderson, Dirk N Darnell, Cathleen Frein, Danielle L Fink, Karen P Lau, Debra A Long Priel, John I Gallin, Harry L Malech, Gulbu Uzel, Alexandra F Freeman, Douglas B Kuhns, Sergio D Rosenzweig, Steven M Holland
BACKGROUND: Chronic granulomatous disease (CGD) is characterized by recurrent life-threatening bacterial and fungal infections and aberrant inflammation. Mutations in CYBB cause X-linked CGD and account for 65%-70% of cases in western countries. OBJECTIVE: To understand the clinical manifestations associated with the X-linked CGD carrier state. METHODS: We undertook a comprehensive retrospective study of 162 affected females. We examined dihydrorhodamine oxidation (DHR) data for percent (%) X chromosome inactivation...
May 17, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28496957/injecting-and-sexual-networks-and-sociodemographic-factors-and-dual-hiv-risk-among-people-who-inject-drugs-a-cross-sectional-study-in-kermanshah-province-iran
#2
Mehdi Noroozi, Ali Mirzazadeh, Alireza Noroozi, Hamid Sharifi, Peter Higgs, Zahra Jorjoran-Shushtari, Ali Farhoudian, Farbod Fadai, Farahnaz Mohhamadi-Shahboulaghi, Bahram Armoon, Ahmad Hajebi, Omid Massah
BACKGROUND: Few studies suggest that social network factors, including size of sexual network may associate with drug-related and sexual high-risk behaviors. The objective of this study is to investigate injecting and sexual networks and sociodemographic factors that might be associated with dual HIV risk (DHR) among people who inject drug (PWID). METHODS: The data from a cross-sectional study of 455 PWID that were recruited through peer-referral sampling were used in this study...
July 2016: Addiction & Health
https://www.readbyqxmd.com/read/28453604/modelling-seasonal-and-spatio-temporal-variation-in-respiratory-prescribing
#3
Eleni Sofianopoulou, Tanja Pless-Mulloli, Stephen Rushton, Peter J Diggle
Many measures of chronic diseases including respiratory disease exhibit seasonal variation together with residual correlation between consecutive time-periods and neighboring areas. We demonstrate a modern strategy for modelling data that exhibit both seasonal trend and spatio-temporal correlation, through an application to respiratory prescribing. We analyzed 55 months (2002-2006) of prescribing data, in the northeast of England, UK. We estimated the seasonal pattern of prescribing by fitting a dynamic harmonic regression (DHR) model to salbutamol prescribing in relation to temperature...
April 27, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28414928/new-iminodibenzyl-derivatives-with-anti-leishmanial-activity
#4
Anderson Arndt, Cleber Wanderlei Liria, Jenicer K U Yokoyama-Yasunaka, M Terêsa Machini, Sílvia Reni Bortolin Uliana, Breno Pannia Espósito
Leishmaniasis is an infection caused by protozoa of the genus Leishmania and transmitted by sandflies. Current treatments are expensive and time-consuming, involving Sb(V)-based compounds, lipossomal amphotericin B and miltefosine. Recent studies suggest that inhibition of trypanothione reductase (TR) could be a specific target in the development of new drugs because it is essential and exclusive to trypanosomatids. This work presents the synthesis and characterization of new iminodibenzyl derivatives (dado) with ethylenediamine (ea), ethanolamine (en) and diethylenetriamine (dien) and their copper(II) complexes...
April 4, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28398961/accreditation-council-for-graduate-medical-education-acgme-surgery-resident-operative-logs-the-last-quarter-century
#5
Frederick Thurston Drake, Shahram Aarabi, Brandon T Garland, Ciara R Huntington, Jarod P McAteer, Morgan K Richards, Nicole Kansier Zern, Kenneth W Gow
STUDY OBJECTIVE: To describe secular trends in operative experience for surgical trainees across an extended period using the most comprehensive data available, the Accreditation Council for Graduate Medical Education (ACGME) case logs. BACKGROUND: Some experts have expressed concern that current trainees are inadequately prepared for independent practice. One frequently mentioned factor is whether duty hours' restrictions (DHR) implemented in 2003 and 2004 contributed by reducing time spent in the operating room...
May 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28398663/early-childhood-development-of-boys-with-genital-anomalies
#6
Francisco J Schneuer, Jason P Bentley, Andrew J A Holland, Samantha J Lain, Sarra E Jamieson, Nadia Badawi, Natasha Nassar
BACKGROUND: Male genital anomalies often require surgery in early life to address functional and cosmetic consequences. However, there has been little assessment of developmental outcomes of affected boys. METHODS: We conducted a population-based cohort study of all boys born in New South Wales, Australia, and undergoing school-entry developmental assessment in 2009 or 2012. Health and developmental information was obtained by means of record-linkage of birth, hospital and Australian Early Development Census data...
May 1, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28357129/ultraviolet-irradiation-increases-green-fluorescence-of-dihydrorhodamine-dhr-123-false-positive-results-for-reactive-oxygen-species-generation
#7
Pascal Djiadeu, Dhia Azzouz, Meraj A Khan, Lakshmi P Kotra, Neil Sweezey, Nades Palaniyar
Dihydrorhodamine (DHR) 123 is a fluorophore commonly used for measuring reactive oxygen species (ROS), often after exposing cells to ultraviolet (UV) irradiation or oxidative burst inducers such as Phorbol 12-myristate 13-acetate (PMA). However, the negative effects of UV irradiation on oxidation of DHR123 itself to green fluorescence rhodamine (R) 123 under different experimental conditions (e.g., different buffers, media, cells, ROS detection techniques) have not been fully appreciated. We determined the effect of UV on DHR123 fluorescence, using a cell-free system, and A549 epithelial cells, NIH/3T3 fibroblast cells, Jurkat T cells, primary human T cells, HL-60 neutrophils and primary human neutrophils...
April 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28345771/effect-of-intra-cellular-trafficking-on-flow-cytometric-measurement-of-neutrophil-s-oxidative-status-in-iron-deficient-pregnant-females
#8
Soha R Youssef, Sherif F Hendawy, Noha H Boshnak, Mariana S Sedhom
BACKGROUND: Iron deficiency and iron deficiency anemia are prevalent among pregnant women particularly in developing countries. This study aimed to evaluate the iron status among Egyptian pregnant women and its impact on their neutrophil's count and antimicrobial functions. METHOD: Ninety pregnant females underwent complete blood count, iron profile, flow cytometric studies for neutrophil myeloperoxidase expression & oxidative burst using dihydrorhodamine 123 (DHR) after phorbol-12-myristate-13-acetate (PMA) stimulation as well as neutrophil phagocytic and lytic indices...
March 27, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28315874/multiple-drug-hypersensitivity
#9
Werner J Pichler, Yuttana Srinoulprasert, James Yun, Oliver Hausmann
Multiple drug hypersensitivity (MDH) is a syndrome that develops as a consequence of massive T-cell stimulations and is characterized by long-lasting drug hypersensitivity reactions (DHR) to different drugs. The initial symptoms are mostly severe exanthems or drug rash with eosinophilia and systemic symptoms (DRESS). Subsequent symptoms due to another drug often appear in the following weeks, overlapping with the first DHR, or months to years later after resolution of the initial presentation. The second DHR includes exanthema, erythroderma, DRESS, Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), hepatitis, and agranulocytosis...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28293415/approach-to-the-diagnosis-of-drug-hypersensitivity-reactions-similarities-and-differences-between-europe-and-north-america
#10
REVIEW
M J Torres, A Romano, G Celik, P Demoly, D A Khan, E Macy, M Park, K Blumenthal, W Aberer, M Castells, A Barbaud, C Mayorga, P Bonadonna
Drug hypersensitivity reactions (DHRs) affect an unknown proportion of the general population, and are an important public health problem due to their potential to cause life-threatening anaphylaxis and rare severe cutaneous allergic reactions. DHR evaluations are frequently needed in both ambulatory and hospital settings and have a complex diagnosis that requires a detailed clinical history and other tests that may include in vitro tests and in vivo procedures such as skin tests and drug provocation tests...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28287327/mechanism-of-cell-intrinsic-adaptation-to-adams-oliver-syndrome-gene-dock6-disruption-highlights-ubiquitin-like-modifier-isg15-as-a-regulator-of-rho-gtpases
#11
Berati Cerikan, Elmar Schiebel
DOCK6 is a RAC1/CDC42 guanine nucleotide exchange factor, however, little is known about its function and sub-cellular localization. DOCK6 regulates the balance between RAC1 and RHOA activity during cell adhesion and is important for CDC42-dependent mitotic chromosome alignment. Surprisingly, a cell intrinsic adaptation mechanism compensates for errors in these DOCK6 functions that arise as a consequence of prolonged DOCK6 depletion or complete removal in DOCK6 knockout cells. Down-regulation of the ubiquitin-like modifier ISG15 accounts for this adaptation...
February 23, 2017: Small GTPases
https://www.readbyqxmd.com/read/28284381/mechanisms-of-drug-induced-interstitial-nephritis
#12
REVIEW
Rajeev Raghavan, Saed Shawar
Drug-induced acute interstitial nephritis (DI-AIN) is a drug hypersensitivity reaction (DHR) that manifests 7 to 10 days after exposure to the culprit drug. DHRs account for fewer than 15% of reported adverse drug reactions. The kidneys are susceptible to DHR because: (1) the high renal blood flow whereby antigens are filtered, secreted, or concentrated, and (2) it is a major site of excretion for drugs and drug metabolites. More than 250 different drugs from various classes have been incriminated as causative agents of DI-AIN, the third most common cause of acute kidney injury in the hospital...
March 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28174072/molecular-characterization-and-functional-analyses-of-a-diapause-hormone-receptor-like-gene-in-parthenogenetic-artemia
#13
Hui-Li Ye, Dong-Rui Li, Jin-Shu Yang, Dian-Fu Chen, Stephanie De Vos, Marnik Vuylsteke, Patrick Sorgeloos, Gilbert Van Stappen, Peter Bossier, Hiromichi Nagasawa, Wei-Jun Yang
In arthropods, mature females under certain conditions produce and release encysted gastrula embryos that enter diapause, a state of obligate dormancy. The process is presumably regulated by diapause hormone (DH) and diapause hormone receptor (DHR) that were identified in the silkworm, Bombyx mori and other insects. However, the molecular structure and function of DHR in crustaceans remains unknown. Here, a DHR-like gene from parthenogenetic Artemia (Ar-DHR) was isolated and sequenced. The cDNA sequence consists of 1410bp with a 1260-bp open reading frame encoding a protein consisting of 420 amino acid residues...
April 2017: Peptides
https://www.readbyqxmd.com/read/28155235/the-danish-hd-registry-dhr-a-nationwide-family-registry-of-hd-families-in-denmark
#14
Mette Gilling, Esben Budtz-Jørgensen, Susanne E Boonen, Dorte Lildballe, Anders Bojesen, Jens Michael Hertz, Sven Asger Sørensen
The Danish Huntington's Disease Registry (DHR) is a nationwide family registry comprising 14.245 individuals from 445 HD families of which the largest family includes 845 individuals in 8 generations. 1.136 DNA and/or blood samples and 18 fibroblast cultures are stored in a local biobank. The birthplace of the oldest HD carrier in each of the 261 families of Danish origin was unevenly distributed across Denmark with a high number of families in the middle part of the peninsula Jutland and in Copenhagen, the capital...
February 2, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28069423/identification-and-characterization-of-pyrokinin-and-capa-peptides-and-corresponding-gpcrs-from-spotted-wing-drosophila-drosophila-suzukii
#15
Man-Yeon Choi, Seung-Joon Ahn, A Young Kim, Youngho Koh
The family of FXPRLamide peptides serves as a major insect hormone. It is characterized by a core active amino acid sequence conserved at the C-terminal ends, and provides various physiological roles across the Insecta. In this study we identified and characterized pyrokinin (PK) and CAPA cDNAs encoding two FXPRLamide peptides, pyrokinin and CAPA-DH (diapause hormone), and two corresponding G protein-coupled receptors (GPCRs) from spotted wing drosophila (SWD), Drosophila suzukii. Expressions of PK and CAPA mRNAs were differentially observed during all life stages except the embryo, and the detection of CAPA transcription was relatively strong compared with the PK gene in SWD...
May 15, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27992310/a-kinetic-study-of-reactive-oxygen-species-in-rainbow-trout-hepatocytes-by-fluorometry
#16
Mazyar Yazdani, Ketil Hylland
The kinetics of reactive oxygen species (ROS) formation in a primary culture of rainbow trout hepatocytes was investigated using three fluorescent probes: 5-,6-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate (CM-H2DCFDA), dihydrorhodamine 123 (DHR 123), and dihydroethidium (DHE). The cell cultures were loaded with the three probes, separately. Hepatocytes were then exposed to Cu (0.15-10 mM) in serum-free Leibovitz's medium for 30 min before being quantified by a fluorescence plate reader during 30 min...
2016: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/27986623/one-year-incidence-of-prosthetic-joint-infection-in-total-hip-arthroplasty-a-cohort-study-with-linkage-of-the-danish-hip-arthroplasty-register-and-danish-microbiology-databases
#17
P H Gundtoft, A B Pedersen, H C Schønheyder, J K Møller, S Overgaard
OBJECTIVE: To examine the trend of Prosthetic Joint Infections (PJI) following primary total hip arthroplasty (THA) and the antimicrobial resistance of the bacteria causing these infections. MATERIALS AND METHODS: We identified a population-based cohort of patients in the Danish Hip Arthroplasty Register (DHR) who had primary THA and received their surgery in Jutland or Funen between 2005 and 2014. We followed the patients until revision, emigration, death, or up to 1-year of follow-up...
May 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27978482/sensitivity-of-the-green-algae-chlamydomonas-reinhardtii-to-gamma-radiation-photosynthetic-performance-and-ros-formation
#18
Tânia Gomes, Li Xie, Dag Brede, Ole-Christian Lind, Knut Asbjørn Solhaug, Brit Salbu, Knut Erik Tollefsen
The aquatic environment is continuously exposed to ionizing radiation from both natural and anthropogenic sources, making the characterization of ecological and health risks associated with radiation of large importance. Microalgae represent the main source of biomass production in the aquatic ecosystem, thus becoming a highly relevant biological model to assess the impacts of gamma radiation. However, little information is available on the effects of gamma radiation on microalgal species, making environmental radioprotection of this group of species challenging...
February 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/27960170/classification-of-drug-hypersensitivity-into-allergic-p-i-and-pseudo-allergic-forms
#19
REVIEW
Werner J Pichler, Oliver Hausmann
Drug hypersensitivity reactions (DHR) are clinically and functionally heterogeneous. Different subclassifications based on timing of symptom appearance or type of immune mechanism have been proposed. Here, we show that the mode of action of drugs leading to immune/inflammatory cell stimulation is a further decisive factor in understanding and managing DHR. Three mechanisms can be delineated: (a) some drugs have or gain the ability to bind covalently to proteins, form new antigens, and thus elicit immune reactions to hapten-carrier complexes (allergic/immune reaction); (b) a substantial part of immune-mediated DHR is due to a typical off-target activity of drugs on immune receptors like HLA and TCR (pharmacological interaction with immune receptors, p-i reactions); such p-i reactions are linked to severe DHR; and (c) symptoms of DHR can also appear if the drug stimulates or inhibits receptors or enzymes of inflammatory cells (pseudo-allergy)...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27940704/planned-birth-before-39-weeks-and-child-development-a-population-based-study
#20
Jason P Bentley, Christine L Roberts, Jenny R Bowen, Andrew J Martin, Jonathan M Morris, Natasha Nassar
OBJECTIVE: To investigate the association of gestational age and mode of birth with early child development. METHODS: Population-based record linkage cohort study was conducted among 153 730 live-born infants of ≥32 weeks' gestation with developmental assessments at school age, in New South Wales, Australia, 2002 to 2007. Children were assessed in 5 domains: physical health and well-being, language and cognition, social competence, emotional maturity, and general knowledge and communication...
December 2016: Pediatrics
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