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https://www.readbyqxmd.com/read/28619193/protein-losing-enteropathy-in-patients-with-congenital-heart-disease
#1
Maxim Itkin, David A Piccoli, Gregory Nadolski, Jack Rychik, Aaron DeWitt, Erin Pinto, Jonathan Rome, Yoav Dori
BACKGROUND: Protein-losing enteropathy (PLE), characterized by loss of proteins in the intestine, is a devastating complication in patients with congenital heart disease. The cause of PLE is unknown, but lymphatic involvement has been suspected. OBJECTIVES: The authors evaluated the use of lymphangiographic imaging and liver lymphatic embolization as a treatment for PLE. METHODS: This was a single-center, retrospective review of imaging and interventions used in 8 consecutive patients with liver lymphatic embolization and congenital heart disease with elevated central venous pressure complicated by PLE...
June 20, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28494978/post-operative-chylothorax-in-patients-with-congenital-heart-disease
#2
Jill J Savla, Maxim Itkin, Joseph W Rossano, Yoav Dori
BACKGROUND: Post-operative chylothorax in patients with congenital heart disease is a challenging problem with substantial morbidity and mortality. Currently, the etiology of chylothorax is poorly understood and treatment options are limited. OBJECTIVES: This study aimed to report lymphatic imaging findings, determine the mechanism of chylothorax after cardiac surgery, and analyze the outcomes of lymphatic embolization. METHODS: We conducted a retrospective review of 25 patients with congenital heart disease and post-operative chylothorax who presented for lymphatic imaging and intervention between July 2012 and August 2016...
May 16, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28183988/molecular-imaging-of-vulnerable-coronary-plaque-a-pathophysiologic-perspective
#3
Sandeep Krishnan, Yuka Otaki, Mhairi Doris, Leandro Slipczuk, Yoav Arnson, Mathieu Rubeaux, Damini Dey, Piotr Slomka, Daniel S Berman, Balaji Tamarappoo
Atherothrombotic events in coronary arteries are most often due to rupture of unstable plaque resulting in myocardial infarction. Radiolabeled molecular imaging tracers directed toward cellular targets that are unique to unstable plaque can serve as a powerful tool for identifying high-risk patients and for assessing the potential of new therapeutic approaches. Two commonly available radiopharmaceuticals-(18)F-FDG and (18)F-NaF-have been used in clinical research for imaging coronary artery plaque, and ongoing clinical studies are testing whether there is an association between (18)F-NaF uptake and future atherothrombotic events...
March 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27993320/novel-lymphatic-imaging-techniques
#4
REVIEW
Yoav Dori
The lymphatic system plays an important role in immune regulation, transport of metabolites, and fluid balance. The key circulatory role of the lymphatic system is to transport fluid from tissue back into the venous system via lymphovenous connections. Despite the centuries-old recognition of this key role, there has been poor understanding of lymphatic flow pathophysiology because of a lack of a simple reliable noninvasive clinical lymphatic imaging method. This lack of clinical imaging has limited the treatment options for patients with lymphatic flow disorders...
December 2016: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/27662847/implantation-of-the-medtronic-harmony-transcatheter-pulmonary-valve-improves-right-ventricular-size-and-function-in-an-ovine-model-of-postoperative-chronic-pulmonary-insufficiency
#5
Rosanne C Schoonbeek, Satoshi Takebayashi, Chikashi Aoki, Toru Shimaoka, Matthew A Harris, Gregory L Fu, Timothy S Kim, Yoav Dori, Jeremy McGarvey, Harold Litt, Wobbe Bouma, Gerald Zsido, Andrew C Glatz, Jonathan J Rome, Robert C Gorman, Joseph H Gorman, Matthew J Gillespie
BACKGROUND: Pulmonary insufficiency is the nexus of late morbidity and mortality after transannular patch repair of tetralogy of Fallot. This study aimed to establish the feasibility of implantation of the novel Medtronic Harmony transcatheter pulmonary valve (hTPV) and to assess its effect on pulmonary insufficiency and ventricular function in an ovine model of chronic postoperative pulmonary insufficiency. METHODS AND RESULTS: Thirteen sheep underwent baseline cardiac magnetic resonance imaging, surgical pulmonary valvectomy, and transannular patch repair...
October 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27599255/diagnosis-and-treatment-of-lymphatic-plastic-bronchitis-in-adults-using-advanced-lymphatic-imaging-and-percutaneous-embolization
#6
Maxim G Itkin, Francis X McCormack, Yoav Dori
RATIONALE: Plastic bronchitis is a condition characterized by expectoration of branching bronchial casts. Although the mechanism of cast formation in adults with plastic bronchitis remains poorly understood, abnormal pulmonary lymphatic flow resulting in molding of congealing lymphatic fluids in the airway has been documented as a cause of the disease in children with congenital heart disease. OBJECTIVES: To use advanced lymphatic imaging techniques, including dynamic contrast-enhanced magnetic resonance (MR) lymphangiography (DCMRL) and intranodal lymphangiography, to investigate the mechanism of cast formation in adult patients with plastic bronchitis, and to evaluate the therapeutic outcome of percutaneous lymphatic embolization for these patients...
October 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27423853/etiology-and-new-treatment-options-for-patients-with-plastic-bronchitis
#7
EDITORIAL
Yoav Dori, Maxim Itkin
No abstract text is available yet for this article.
August 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27297208/cerebral-lipiodol-embolism-after-lymphatic-embolization-for-plastic-bronchitis
#8
Matthew P Kirschen, Yoav Dori, Maxim Itkin, Daniel J Licht, Rebecca Ichord, Arastoo Vossough
An adolescent with plastic bronchitis due to congenital heart disease had altered mental status after an interventional lymphatic procedure in which lipiodol contrast was used. Neuroimaging revealed cerebral lipiodol embolization due to direct shunting between lymphatic channels and pulmonary veins. Cerebral lipiodol embolization is a potential neurologic morbidity associated with interventional lymphatic procedures.
September 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27189502/the-influence-of-deficient-retro-aortic-rim-on-technical-success-and-early-adverse-events-following-device-closure-of-secundum-atrial-septal-defects-an-analysis-of-the-impact-registry-%C3%A2
#9
MULTICENTER STUDY
Michael L O'Byrne, Matthew J Gillespie, Kevin F Kennedy, Yoav Dori, Jonathan J Rome, Andrew C Glatz
BACKGROUND: Concern regarding aortic erosion has focused attention on the retro-aortic rim in patients undergoing device closure of atrial septal defects (ASD), but its effect on early outcomes is not well studied. METHODS: A multicenter retrospective cohort study of patients undergoing device occlusion of ASD between 1/2011-10/2014 was performed, using data from the IMproving Pediatric and Adult Congenital Treatment Registry. Subjects were divided between those with retro-aortic rim <5 and ≥5 mm...
January 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/26864093/percutaneous-lymphatic-embolization-of-abnormal-pulmonary-lymphatic-flow-as-treatment-of-plastic-bronchitis-in-patients-with-congenital-heart-disease
#10
Yoav Dori, Marc S Keller, Jonathan J Rome, Matthew J Gillespie, Andrew C Glatz, Kathryn Dodds, David J Goldberg, Samuel Goldfarb, Jack Rychik, Maxim Itkin
BACKGROUND: Plastic bronchitis is a potentially fatal disorder occurring in children with single-ventricle physiology, and other diseases, as well, such as asthma. In this study, we report findings of abnormal pulmonary lymphatic flow, demonstrated by MRI lymphatic imaging, in patients with plastic bronchitis and percutaneous lymphatic intervention as a treatment for these patients. METHODS AND RESULTS: This is a retrospective case series of 18 patients with surgically corrected congenital heart disease and plastic bronchitis who presented for lymphatic imaging and intervention...
March 22, 2016: Circulation
https://www.readbyqxmd.com/read/26582175/the-effect-of-radiation-shields-on-operator-exposure-during-congenital-cardiac-catheterisation
#11
Sarosh P Batlivala, Dennise Magill, Marc A Felice, Virginia Jones, Yoav Dori, Matthew J Gillespie, Jonathan J Rome, Andrew C Glatz
Cardiac catheterisation personnel are exposed to occupational radiation and its health risks. Little data exist regarding the efficacy of radiation-protective equipment from congenital catheterisation laboratories (CLs). The authors retrospectively reviewed data in which CL operators wore a radiation dosemeter during catheterizations on patients of >20 kg. A leaded under-table skirt was present in all cases. Three additional radiation-protective devices were utilised at operator discretion: a top extension to the under-table skirt, a ceiling-mounted shield and a disposable patient drape...
December 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/26552510/cost-comparison-of-transcatheter-and-operative-pulmonary-valve-replacement-from-the-pediatric-health-information-systems-database
#12
MULTICENTER STUDY
Michael L O'Byrne, Matthew J Gillespie, Russell T Shinohara, Yoav Dori, Jonathan J Rome, Andrew C Glatz
Outcomes for transcatheter pulmonary valve replacement (TC-PVR) and operative pulmonary valve replacement (S-PVR) are excellent. Thus, their respective cost is a relevant clinical outcome. We performed a retrospective cohort study of children and adults who underwent PVR at age ≥ 8 years from January 1, 2011, to December 31, 2013, at 35 centers contributing data to the Pediatric Health Information Systems database to address this question. A propensity score-adjusted multivariable analysis was performed to adjust for known confounders...
January 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/26541153/intra-procedural-bronchoscopy-to-prevent-bronchial-compression-during-pulmonary-artery-stent-angioplasty
#13
Michael L O'Byrne, Nita Rome, Ramiro W Lizano Santamaria, Anna Hallbergson, Andrew C Glatz, Yoav Dori, Matthew J Gillespie, Samuel Goldfarb, Andrew R Haas, Jonathan J Rome
Stenosis of the pulmonary arteries frequently occurs during staged palliation of hypoplastic left heart syndrome and variants, often necessitating stent angioplasty. A complication of stent angioplasty is compression of the ipsilateral mainstem bronchus. Following such a case, we re-evaluated our approach to PA stent angioplasty in these patients. The incident case is described. A retrospective observational study of children and adults with superior (SCPC) and/or total cavopulmonary connection (TCPC) undergoing left pulmonary artery (LPA) stent angioplasty between January 1, 2005 and January 5, 2014 and subsequent chest CT was performed to assess the incidence of bronchial compression...
March 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/26385453/factors-associated-with-systemic-to-pulmonary-arterial-collateral-flow-in-single-ventricle-patients-with-superior-cavopulmonary-connections
#14
Andrew C Glatz, Neil Harrison, Adam J Small, Yoav Dori, Matthew J Gillespie, Matthew A Harris, Mark A Fogel, Jonathan J Rome, Kevin K Whitehead
OBJECTIVE: Systemic to pulmonary arterial collateral flow (CollF) is common in single ventricle patients with superior cavopulmonary connections (SCPC), although associations with CollF are not well understood. We previously described a method to quantify CollF by cardiac MRI (CMR). We sought to identify factors associated with CollF in a large cross section of patients with SCPC. METHODS: A retrospective observational cohort study of events from birth to study CMR was performed for all patients with SCPC who had CollF quantified by CMR...
November 2015: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/26361158/predictors-of-catastrophic-adverse-outcomes-in-children-with-pulmonary-hypertension-undergoing-cardiac-catheterization-a-multi-institutional-analysis-from-the-pediatric-health-information-systems-database
#15
MULTICENTER STUDY
Michael L O'Byrne, Andrew C Glatz, Brian D Hanna, Russell T Shinohara, Matthew J Gillespie, Yoav Dori, Jonathan J Rome, Steven M Kawut
BACKGROUND: Cardiac catheterization is the standard of care procedure for diagnosis, choice of therapy, and longitudinal follow-up of children and adults with pulmonary hypertension (PH). However, the procedure is invasive and has risks associated with both the procedure and recovery period. OBJECTIVES: The purpose of this study was to identify risk factors for catastrophic adverse outcomes in children with PH undergoing cardiac catheterization. METHODS: We studied children and young adults up to 21 years of age with PH undergoing 1 or more cardiac catheterization at centers participating in the Pediatric Health Information Systems database between 2007 and 2012...
September 15, 2015: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/26152515/palliative-balloon-pulmonary-valvuloplasty-for-infants-with-unrestrictive-ventricular-septal-defect-or-single-ventricle-associated-with-severe-pulmonary-stenosis
#16
Ramiro W Lizano Santamaria, Matthew J Gillespie, Yoav Dori, Jonathan J Rome, Andrew C Glatz
BACKGROUND: Symptomatic infants with unrestrictive ventricular septal defect (VSD) or single ventricle with severe pulmonary stenosis (PS) are typically treated surgically. High surgical risk infants may benefit from catheter-based palliative pulmonary valvuloplasty. METHODS: We retrospectively reviewed all patients with severe PS associated with unrestrictive VSD or single ventricle who underwent palliative pulmonary valvuloplasty as initial management and describe outcomes...
November 2015: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/26027620/effect-of-center-catheterization-volume-on-risk-of-catastrophic-adverse-event-after-cardiac-catheterization-in-children
#17
MULTICENTER STUDY
Michael L O'Byrne, Andrew C Glatz, Russell T Shinohara, Natalie Jayaram, Matthew J Gillespie, Yoav Dori, Jonathan J Rome, Steven Kawut
BACKGROUND: Procedural volume has been shown to be associated with outcome in cardiac catheterization and intervention in adults. The impact of center-level factors (such as volume) and their interaction with subject- and procedure-level factors on outcome after cardiac catheterization in children is not well described. We hypothesized that higher center catheterization volume would be associated with lower risk of catastrophic adverse events. METHODS: We studied children and young adults 0 to 21 years of age undergoing one or more cardiac catheterizations at centers participating in the Pediatric Health Information Systems database between 2007 and 2012...
June 2015: American Heart Journal
https://www.readbyqxmd.com/read/25965721/cost-comparison-of-transcatheter-and-operative-closures-of-ostium-secundum-atrial-septal-defects
#18
COMPARATIVE STUDY
Michael L O'Byrne, Matthew J Gillespie, Russell T Shinohara, Yoav Dori, Jonathan J Rome, Andrew C Glatz
BACKGROUND: Clinical outcomes for transcatheter and operative closures of atrial septal defects (ASDs) are similar. Economic cost for each method has not been well described. METHODS: A single-center retrospective cohort study of children and adults<30 years of age undergoing closure for single secundum ASD from January 1, 2007, to April 1, 2012, was performed to measure differences in inflation-adjusted cost of operative and transcatheter closures of ASD. A propensity score weight-adjusted multivariate regression model was used in an intention-to-treat analysis...
May 2015: American Heart Journal
https://www.readbyqxmd.com/read/25907503/status-of-systemic-to-pulmonary-arterial-collateral-flow-after-the-fontan-procedure
#19
Kevin K Whitehead, Matthew A Harris, Andrew C Glatz, Matthew J Gillespie, Michael V DiMaria, Neil E Harrison, Yoav Dori, Marc S Keller, Jonathan J Rome, Mark A Fogel
The investigators recently validated a method of quantifying systemic-to-pulmonary arterial collateral flow using phase-contrast magnetic resonance imaging velocity mapping. Cross-sectional data suggest decreased collateral flow in patients with total cavopulmonary connections (TCPCs) compared with those with superior cavopulmonary connections (SCPCs). However, no studies have examined serial changes in collateral flow from SCPCs to TCPCs in the same patients. The aim of this study was to examine differences in collateral flow between patients with SCPCs and those with TCPCs...
June 15, 2015: American Journal of Cardiology
https://www.readbyqxmd.com/read/25573820/middle-term-results-of-trans-catheter-creation-of-atrial-communication-in-patients-receiving-mechanical-circulatory-support
#20
Michael L O'Byrne, Andrew C Glatz, Joseph W Rossano, Kellie L Schiavo, Yoav Dori, Jonathan J Rome, Matthew J Gillespie
OBJECTIVE: To describe our center's middle-term outcomes following trans-catheter creation of atrial communication (ASD) in patients on mechanical circulatory support. BACKGROUND: Trans-catheter creation of an ASD in patients on mechanical circulatory support is an adjuvant therapy to reduce left atrial pressure and associated morbidity. Data on middle term outcomes following this procedure, specifically in regards to the fate of the ASD, are limited. METHODS: Retrospective observational study of consecutive children and adults undergoing trans-catheter creation of an atrial septal communication between 1/1/2006 and 5/1/2014, reviewing their baseline characteristics, procedural details, and data from follow-up...
June 2015: Catheterization and Cardiovascular Interventions
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