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https://www.readbyqxmd.com/read/29245084/application-of-analytical-quality-by-design-principles-for-the-determination-of-alkyl-p-toluenesulfonates-impurities-in-aprepitant-by-hplc-validation-using-total-error-concept
#1
Constantinos K Zacharis, Elli Vastardi
In the research presented we report the development of a simple and robust liquid chromatographic method for the quantification of two genotoxic alkyl sulphonate impurities (namely methyl p-toluenesulfonate and isopropyl p-toluenesulfonate) in Aprepitant API substances using the Analytical Quality by Design (AQbD) approach. Following the steps of AQbD protocol, the selected critical method attributes (CMAs) were the separation criterions between the critical peak pairs, the analysis time and the peak efficiencies of the analytes...
December 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29245028/on-site-evaluation-of-wagyu-beef-carcasses-based-on-the-monounsaturated-oleic-and-saturated-fatty-acid-composition-using-a-handheld-fiber-optic-near-infrared-spectrometer
#2
S Piao, T Okura, M Irie
The fat quality is an important aspect, especially for Wagyu beef. A handheld fiber-optic near-infrared spectrometer for on-site evaluation of beef fat quality was developed, and the interactance spectra of the intermuscular fat from 833 Wagyu carcasses at 12 markets were measured. The calibration model was transferred to five slave instruments using twenty-six block samples. The performance of one slave instrument was verified at five meat markets (n=360). The coefficients of determination of the slave instrument for monounsaturated, oleic, and saturated fatty acid compositions determined by gas chromatography and near-infrared measurements were 0...
November 27, 2017: Meat Science
https://www.readbyqxmd.com/read/29244904/pharmacokinetics-of-the-cannabinoid-receptor-ligand-18-f-mk-9470-in-the-rat-brain-evaluation-of-models-using-micropet
#3
Isabelle Miederer, Hans-Georg Buchholz, Andrea Kronfeld, Stephan Maus, Veronika Weyer-Elberich, Philipp Mildenberger, Beat Lutz, Mathias Schreckenberger
PURPOSE: The positron emission tomography ligand [18 F]MK-9470 is an inverse agonist that binds reversibly and with high affinity to the cannabinoid type 1 receptor. Due to its slow brain kinetics, care is required in the definition of its dissociation rates from the receptor. The goal of this study was to investigate pharmacokinetic analysis methods using an arterial input function. METHODS: Five Sprague-Dawley rats received injections of 13 to 25 MBq of [18 F]MK-9470 and were scanned over a period of 90 min...
December 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/29244902/feasibility-of-predicting-tumor-motion-using-online-data-acquired-during-treatment-and-a-generalized-neural-network-optimized-with-offline-patient-tumor-trajectories
#4
Troy Teo, Syed Bilal Ahmed, Nadia Alayoubi, Neil Bruce, Ethan Lyn, Stephen Pistorius
PURPOSE: The accurate prediction of intra-fraction lung tumor motion is required to compensate for system latency in image-guided adaptive radiotherapy systems. The goal of this study was to identify an optimal prediction model that has a short learning period so that prediction and adaptation can commence soon after treatment begins, and requires minimal re-optimization for individual patients. Specifically, the feasibility of predicting tumor position using a combination of a generalized (i...
December 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/29244814/forecasting-influenza-like-illness-dynamics-for-military-populations-using-neural-networks-and-social-media
#5
Svitlana Volkova, Ellyn Ayton, Katherine Porterfield, Courtney D Corley
This work is the first to take advantage of recurrent neural networks to predict influenza-like illness (ILI) dynamics from various linguistic signals extracted from social media data. Unlike other approaches that rely on timeseries analysis of historical ILI data and the state-of-the-art machine learning models, we build and evaluate the predictive power of neural network architectures based on Long Short Term Memory (LSTMs) units capable of nowcasting (predicting in "real-time") and forecasting (predicting the future) ILI dynamics in the 2011 - 2014 influenza seasons...
2017: PloS One
https://www.readbyqxmd.com/read/29244758/protein-subcellular-localization-with-gaussian-kernel-discriminant-analysis-and-its-kernel-parameter-selection
#6
Shunfang Wang, Bing Nie, Kun Yue, Yu Fei, Wenjia Li, Dongshu Xu
Kernel discriminant analysis (KDA) is a dimension reduction and classification algorithm based on nonlinear kernel trick, which can be novelly used to treat high-dimensional and complex biological data before undergoing classification processes such as protein subcellular localization. Kernel parameters make a great impact on the performance of the KDA model. Specifically, for KDA with the popular Gaussian kernel, to select the scale parameter is still a challenging problem. Thus, this paper introduces the KDA method and proposes a new method for Gaussian kernel parameter selection depending on the fact that the differences between reconstruction errors of edge normal samples and those of interior normal samples should be maximized for certain suitable kernel parameters...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29244738/design-of-an-air-pollution-monitoring-campaign-in-beijing-for-application-to-cohort-health-studies
#7
REVIEW
Sverre Vedal, Bin Han, Jia Xu, Adam Szpiro, Zhipeng Bai
No cohort studies in China on the health effects of long-term air pollution exposure have employed exposure estimates at the fine spatial scales desirable for cohort studies with individual-level health outcome data. Here we assess an array of modern air pollution exposure estimation approaches for assigning within-city exposure estimates in Beijing for individual pollutants and pollutant sources to individual members of a cohort. Issues considered in selecting specific monitoring data or new monitoring campaigns include: needed spatial resolution, exposure measurement error and its impact on health effect estimates, spatial alignment and compatibility with the cohort, and feasibility and expense...
December 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29244530/establishing-measurement-equivalence-across-computer-and-paper-based-tests-of-spatial-cognition
#8
Shannon K T Bailey, Alexis R Neigel, Lindsay Y Dhanani, Valerie K Sims
Objective The purpose of the present research is to establish measurement equivalence and test differences in reliability between computerized and pencil-and-paper-based tests of spatial cognition. Background Researchers have increasingly adopted computerized test formats, but few attempt to establish equivalence for computer-based and paper-based tests. The mixed results in the literature on the test mode effect, which occurs when performance differs as a function of test medium, highlight the need to test for, instead of assume, measurement equivalence...
December 1, 2017: Human Factors
https://www.readbyqxmd.com/read/29244163/regulation-of-chromosome-segregation-in-oocytes-and-the-cellular-basis-for-female-meiotic-errors
#9
Jessica Greaney, Zhe Wei, Hayden Homer
BACKGROUND: Meiotic chromosome segregation in human oocytes is notoriously error-prone, especially with ageing. Such errors markedly reduce the reproductive chances of increasing numbers of women embarking on pregnancy later in life. However, understanding the basis for these errors is hampered by limited access to human oocytes. OBJECTIVE AND RATIONALE: Important new discoveries have arisen from molecular analyses of human female recombination and aneuploidy along with high-resolution analyses of human oocyte maturation and mouse models...
December 13, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29244131/reporting-antimicrobial-susceptibilities-and-resistance-phenotypes-in-acinetobacter-spp-a-nationwide-proficiency-study
#10
Felipe Fernández-Cuenca, María Tomás, Francisco-Javier Caballero-Moyano, Germán Bou, Álvaro Pascual
Objectives: To evaluate the proficiency of Spanish microbiology laboratories with respect to the antimicrobial susceptibility testing (AST) of Acinetobacter spp. Methods: Eight Acinetobacter spp. with different resistance mechanisms were sent to 48 Spanish centres which were asked to report: (i) the AST system used; (ii) MICs; (iii) breakpoints used (CLSI versus EUCAST); (iv) clinical category; and (v) resistance mechanisms inferred. Minor, major and very major errors (mE, ME and VME, respectively) were determined...
December 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29244044/examining-the-factor-structure-and-reliability-of-the-safe-patient-handling-perception-scale-an-initial-validation-study
#11
Regina White-Heisel, James P Canfield, Sadie Young-Hughes
PURPOSE: Perceiving imminent safe patient handling and movement (SPH&M) dangers may reduce musculoskeletal (MSK) injuries for nurses in the workplace. The purpose of this study is to develop and validate the 17-item Safe Patient Handling Perception Scale (SPHPS) as an evaluation instrument assessing perceptual risk of MSK injury based on SPH&M knowledge, practice, and resource accessibility in the workplace. METHODS: Data were collected from a convenience sample (N = 117) of nursing employees at a Veteran Affairs Medical Center...
May 2017: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29244017/implications-of-segment-mismatch-for-influenza-a-virus-evolution
#12
Maria C White, Anice C Lowen
Influenza A virus (IAV) is an RNA virus with a segmented genome. These viral properties allow for the rapid evolution of IAV under selective pressure, due to mutation occurring from error-prone replication and the exchange of gene segments within a co-infected cell, termed reassortment. Both mutation and reassortment give rise to genetic diversity, but constraints shape their impact on viral evolution: just as most mutations are deleterious, most reassortment events result in genetic incompatibilities. The phenomenon of segment mismatch encompasses both RNA- and protein-based incompatibilities between co-infecting viruses and results in the production of progeny viruses with fitness defects...
December 15, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29244014/camsa-a-tool-for-comparative-analysis-and-merging-of-scaffold-assemblies
#13
Sergey S Aganezov, Max A Alekseyev
BACKGROUND: Despite the recent progress in genome sequencing and assembly, many of the currently available assembled genomes come in a draft form. Such draft genomes consist of a large number of genomic fragments (scaffolds), whose positions and orientations along the genome are unknown. While there exists a number of methods for reconstruction of the genome from its scaffolds, utilizing various computational and wet-lab techniques, they often can produce only partial error-prone scaffold assemblies...
December 6, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29244003/single-molecule-sequencing-guided-scaffolding-and-correction-of-draft-assemblies
#14
Shenglong Zhu, Danny Z Chen, Scott J Emrich
BACKGROUND: Although single molecule sequencing is still improving, the lengths of the generated sequences are inevitably an advantage in genome assembly. Prior work that utilizes long reads to conduct genome assembly has mostly focused on correcting sequencing errors and improving contiguity of de novo assemblies. RESULTS: We propose a disassembling-reassembling approach for both correcting structural errors in the draft assembly and scaffolding a target assembly based on error-corrected single molecule sequences...
December 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29243976/stereotactic-eeg-via-multiple-single-path-omnidirectional-trajectories-within-a-single-platform-institutional-experience-with-a-novel-technique
#15
Michael C Dewan, Robert Shults, Andrew T Hale, Vishad Sukul, Dario J Englot, Peter Konrad, Hong Yu, Joseph S Neimat, William Rodriguez, Benoit M Dawant, Srivatsan Pallavaram, Robert P Naftel
OBJECTIVE Stereotactic electroencephalography (SEEG) is being used with increasing frequency to interrogate subcortical, cortical, and multifocal epileptic foci. The authors describe a novel technique for SEEG in patients with suspected epileptic foci refractory to medical management. METHODS In the authors' technique, standard epilepsy evaluation and neuroimaging are used to create a hypothesis-driven SEEG plan, which informs the 3D printing of a novel single-path, multiple-trajectory, omnidirectional platform...
December 15, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29243748/global-minimum-profile-error-gmpe-a-least-squares-based-approach-for-extracting-macroscopic-rate-coefficients-for-complex-gas-phase-chemical-reactions
#16
Minh V Duong, Hieu T Nguyen, Tam V-T Mai, Lam K Huynh
Master equation/Rice-Ramsperger-Kassel-Marcus (ME/RRKM) has shown to be a powerful framework for modeling kinetic and dynamic behaviors of a complex gas-phase chemical system on a complicated multiple-species and multiple-channel potential energy surface (PES) for a wide range of temperatures and pressures. Derived from the ME time-resolved species profiles, the macroscopic or phenomenological rate coefficients are essential for many reaction engineering applications including those in combustion and atmospheric chemistry...
December 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29243739/frozen-sections-are-unreliable-for-the-diagnosis-of-necrotizing-soft-tissue-infections
#17
Isaac H Solomon, Rene Borscheid, Alvaro C Laga, Reza Askari, Scott R Granter
Necrotizing soft tissue infections are rare but are associated with high rates of morbidity and mortality. The use of bedside or intraoperative frozen sections has been reported to be associated with faster diagnosis and better outcomes; however, to date no large studies have been published to determine the sensitivity and specificity of frozen sections in this setting. Twenty years of cases suspicious for necrotizing soft tissue infection at a large academic referral center were reviewed, blinded to the final clinical diagnosis (gold standard)...
December 15, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29243530/electrophysiological-markers-of-motivation-in-psychosis
#18
Kazuki Sueyoshi, Tomiki Sumiyoshi
Motivation is associated with electrophysiological markers, such as awake state delta oscillation and frontal alpha asymmetry, as well as event-related potentials, such as error-related negativity, feedback-related negativity, and prepulse inhibition. These indicators provide an objective measure of motivational deficits in psychiatric conditions, and response to treatment. Also, these modalities of brain activities are drawing attention as a target of neurofeedback training. The aim of this article is to provide a brief overview on electrophysiological findings relevant to the understanding of the mechanisms underlying impaired motivation in psychiatric disorders and clinical practice...
January 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29243375/parental-experiences-and-perceptions-of-infant-complementary-feeding-a-qualitative-evidence-synthesis
#19
REVIEW
K Matvienko-Sikar, C Kelly, C Sinnott, J McSharry, C Houghton, C Heary, E Toomey, M Byrne, P M Kearney
BACKGROUND: Interventions to prevent childhood obesity increasingly focus on infant feeding, but demonstrate inconsistent effects. A comprehensive qualitative evidence synthesis is essential to better understand feeding behaviours and inform intervention development. The aim of this study is to synthesize evidence on perceptions and experiences of infant feeding and complementary feeding recommendations. METHODS: Databases CINAHL, EMBASE, MEDLINE, PsycINFO, Academic Search Complete, SocIndex and Maternity and Infant Care were searched from inception to May 2017...
December 15, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29243335/comparative-performance-of-pharmacogenetics-based-warfarin-dosing-algorithms-derived-from-caucasian-asian-and-mixed-races-in-thai-population
#20
Supatat Chumnumwat, Kong Yi, Aroonrut Lucksiri, Wichit Nosoongnoen, Busba Chindavijak, Suvatna Chulavatnatol, Ajjima Sarapakdi, Surakit Nathisuwan
AIM: This study was conducted to compare predictive accuracy of the available pharmacogenetics (PGx)-guided warfarin-dosing algorithms derived from Caucasian, Asian and mixed population to identify a suitable algorithm for Thai population. METHODS: Ten warfarin-dosing algorithms derived from different population including Caucasian, East Asian, Southeast Asian and mixed races were selected and tested with clinical and genetic data of Thai patients. Comparative performances of these algorithms were tested using mean dose error (MDE) between actual warfarin maintenance dose (AWMD) and predicted dose generated by each dosing algorithm, and percentage of ideal dose prediction (IDP)...
December 15, 2017: Cardiovascular Therapeutics
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