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https://www.readbyqxmd.com/read/28735490/measurement-of-oncometabolites-d-2-hydroxyglutaric-acid-and-l-2-hydroxyglutaric-acid
#1
Patricia M Jones, Richard Boriack, Eduard A Struys, Dinesh Rakheja
We describe a liquid chromatography-tandem mass spectrometry assay for measurement of D-2-hydroxyglutaric acid and L-2-hydroxyglutaric acid. These metabolites are increased in specific inborn errors of metabolism and are now recognized as oncometabolites. The measurement of D-2-hydroxyglutarate in peripheral blood may be used as a biomarker for screening and follow-up of patients with IDH-mutated acute myeloid leukemia.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28735373/systematic-heuristic-evaluation-of-computerized-consultation-order-templates-clinicians-and-human-factors-engineers-perspectives
#2
April Savoy, Himalaya Patel, Mindy E Flanagan, Michael Weiner, Alissa L Russ
We assessed the usability of consultation order templates and identified problems to prioritize in design efforts for improving referral communication. With a sample of 26 consultation order templates, three evaluators performed a usability heuristic evaluation. The evaluation used 14 domain-independent heuristics and the following three supplemental references: 1 new domain-specific heuristic, 6 usability goals, and coded clinicians' statements regarding ease of use for 10 sampled templates. Evaluators found 201 violations, a mean of 7...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28735346/anatomical-relation-between-nasal-septum-deviation-and-oropharynx-volume-in-different-facial-patterns-evaluated-through-cone-beam-computed-tomography
#3
Ana Márcia Viana Wanzeler, Maria Daniela Oliveira Renda, Maria Eduarda de Oliveira Pereira, Sérgio Melo Alves-Junior, Fabricio Mesquita Tuji
INTRODUCTION: The objective of this study was to establish the anatomical relation between nasal septum deviation (NSD) and oropharynx volume in different facial patterns using cone beam computed tomography (CBCT). METHODS: Ninety CBCT examinations were analyzed. InVivoDental software was used to evaluate cephalometric image reconstructions in terms of facial type, determined from cephalometric measurements indicative of growth direction; the presence of NSD was also evaluated...
July 22, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28735343/exact-probabilities-for-the-indeterminacy-of-complex-networks-as-perceived-through-press-perturbations
#4
David Koslicki, Mark Novak
We consider the goal of predicting how complex networks respond to chronic (press) perturbations when characterizations of their network topology and interaction strengths are associated with uncertainty. Our primary result is the derivation of exact formulas for the expected number and probability of qualitatively incorrect predictions about a system's responses under uncertainties drawn form arbitrary distributions of error. Additional indices provide new tools for identifying which links in a network are most qualitatively and quantitatively sensitive to error, and for determining the volume of errors within which predictions will remain qualitatively determinate (i...
July 22, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28735302/autopsy-interrogation-of-emergency-medicine-dispute-cases-how-often-are-clinical-diagnoses-incorrect
#5
Danyang Liu, Rongchang Gan, Weidi Zhang, Wei Wang, Hexige Saiyin, Wenjiao Zeng, Guoyuan Liu
AIMS: Emergency medicine is a 'high risk' specialty. Some diseases develop suddenly and progress rapidly, and sudden unexpected deaths in the emergency department (ED) may cause medical disputes. We aimed to assess discrepancies between antemortem clinical diagnoses and postmortem autopsy findings concerning emergency medicine dispute cases and to figure out the most common major missed diagnoses. METHODS: Clinical files and autopsy reports were retrospectively analysed and interpreted...
July 22, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28735215/estimation-of-individual-axon-bundle-properties-by-a-multi-resolution-discrete-search-method
#6
Ricardo Coronado-Leija, Alonso Ramirez-Manzanares, Jose Luis Marroquin
A stable, accurate and robust-to-noise method for the estimation of the intra-voxel bundle-wise diffusion properties for diffusion-weighted magnetic resonance imaging is presented. The proposed method overcomes some of the limitations of most of the multi-fiber algorithms in the literature and extends them to estimate the diffusion profiles, improving the estimation of the intra-voxel geometry at challenging microstructure configurations, that is to say: relatively small crossing angles, different voxel-wise anisotropic diffusion profiles and low SNR...
June 29, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28735179/monitoring-road-safety-development-at-regional-level-a-case-study-in-the-asean-region
#7
Faan Chen, Jianjun Wang, Jiaorong Wu, Xiaohong Chen, P Christopher Zegras
Persistent monitoring of progress, evaluating the results of interventions and recalibrating to achieve continuous improvement over time is widely recognized as being crucial towards the successful development of road safety. In the ASEAN (Association of Southeast Asian Nations) region there is a lack of well-resourced teams that contain multidisciplinary safety professionals, and specialists in individual countries, who are able to carry out this work effectively. In this context, not only must the monitoring framework be effective, it must also be easy to use and adapt...
July 20, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28735110/blinded-sample-size-recalculation-in-clinical-trials-incorporating-historical-data
#8
Katharina Hees, Meinhard Kieser
Recruiting sufficient patients within an acceptable time horizon is an issue for most clinical trials and is especially challenging in the field of rare diseases. It is therefore an attractive option to include historical data from previous (pilot) trials in the current study thus reducing the recruitment burden. In clinical trials with binary endpoint, the required sample size does not only depend on the type I error rate, the power, and the treatment group difference but additionally on the overall event rate...
July 19, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28735012/fgwas-functional-genome-wide-association-analysis
#9
Chao Huang, Paul Thompson, Yalin Wang, Yang Yu, Jingwen Zhang, Dehan Kong, Rivka R Colen, Rebecca C Knickmeyer, Hongtu Zhu
Functional phenotypes (e.g., subcortical surface representation), which commonly arise in imaging genetic studies, have been used to detect putative genes for complexly inherited neuropsychiatric and neurodegenerative disorders. However, existing statistical methods largely ignore the functional features (e.g., functional smoothness and correlation). The aim of this paper is to develop a functional genome-wide association analysis (FGWAS) framework to efficiently carry out whole-genome analyses of functional phenotypes...
July 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28735011/assessment-and-elimination-of-the-effects-of-head-movement-on-meg-resting-state-measures-of-oscillatory-brain-activity
#10
Eirini Messaritaki, Loes Koelewijn, Diana C Dima, Gemma M Williams, Gavin Perry, Krish D Singh
Magnetoencephalography (MEG) is increasingly being used to study brain function because of its excellent temporal resolution and its direct association with brain activity at the neuronal level. One possible cause of error in the analysis of MEG data comes from the fact that participants, even MEG-experienced ones, move their head in the MEG system. Head movement can cause source localization errors during the analysis of MEG data, which can result in the appearance of source variability that does not reflect brain activity...
July 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28734971/robotic-assistance-confers-ambidexterity-to-laparoscopic-surgeons
#11
Souzana Choussein, Serene S Srouji, Leslie V Farland, Ashley Wietsma, Stacey A Missmer, Michael Hollis, Richard N Yu, Charles N Pozner, Antonio R Gargiulo
STUDY OBJECTIVE: To examine whether a robotic surgical platform can complement the fine motor skills of the non-dominant hand, compensating for the innate difference in dexterity between the surgeon's hands, thereby conferring virtual ambidexterity. DESIGN: Crossover intervention study. DESIGN CLASSIFICATION: Level II-1 evidence. SETTING: Centers for medical simulation of two tertiary care hospitals of Harvard Medical School...
July 19, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28734859/provider-health-and-wellness
#12
REVIEW
Anil Nanda, Anita Wasan, James Sussman
Provider health and wellness is a significant issue and can impact patient care, including patient satisfaction, quality of care, medical errors, malpractice risk, as well as provider and office staff turnover and early retirement. Health and wellness encompasses various areas including burnout, depression, divorce, and suicide and affects providers of all specialties and at all levels of training. Providers deal with many everyday stresses, including electronic health records, office politics, insurance and billing issues, dissatisfied patients, and their own personal and family issues...
July 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28734561/avoiding-adult-in-hospital-cardiac-arrest-a-retrospective-cohort-study-to-determine-preventability
#13
Gordon Bingham, Irma Bilgrami, Mandy Sandford, Sarah Larwill, Judit Orosz, Carl Luckhoff, Tony Kambourakis
INTRODUCTION: This study had three main aims. Develop a methodology for reviewing in-hospital cardiac arrests (IHCA). Assess appropriateness and potential preventability of IHCAs. Identify areas for improvement within the rapid response system (RRS). DESIGN: A retrospective cohort study of IHCA identified from an existing organisational electronic database of medical emergency (MET) and Code Blue team activation. Potential preventability of IHCA and Code Blue team activation were established by an expert panel based on a standardised case review process with descriptive and content analyses for each IHCA event...
July 19, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28734486/nurse-practitioner-malpractice-data-informing-nursing-education
#14
Casey Fryer Sweeney, Anna LeMahieu, George E Fryer
BACKGROUND: Nurse practitioners (NPs) are often identified in medical malpractice claims. However, the use of malpractice data to inform the development of nursing curriculum is limited. The purpose of this study is to examine medical errors committed by NPs. METHODS: Using National Practitioner Data Bank public use data, years 1990 to 2014, NP malpractice claims were classified by event type, patient outcome, setting, and number of practitioners involved. RESULTS: The greatest proportion of malpractice claims involving nurse practitioners were diagnosis related (41...
July 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/28734371/electrospun-nanofibrous-mercury-filter-efficient-concentration-and-determination-of-trace-mercury-in-water-with-high-sensitivity-and-tunable-dynamic-range
#15
Huaming Wang, Wenyao Huang, Lin Tang, Ying Chen, Ying Zhang, Mengxi Wu, Yi Song, Sheng Wen
Herein, we reported a simple and highly sensitive method for the concentration and determination of trace mercury in water samples based on a novel electropsun nanofibrous mercury filter (ENMF). The method consisted of two simple steps: first, the concentration of mercury on a piece of thiol-containing ENMF; and second, the determination of mercury captured on the ENMF using a direct mercury analyzer (DMA). By changing the volume of water sample, the dynamic range of the method could extend from 0.0025 to 6...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28734365/automatic-feed-phase-identification-in-multivariate-bioprocess-profiles-by-sequential-binary-classification
#16
Ramin Nikzad-Langerodi, Edwin Lughofer, Susanne Saminger-Platz, Thomas Zahel, Patrick Sagmeister, Christoph Herwig
In this paper, we propose a new strategy for retrospective identification of feed phases from online sensor-data enriched feed profiles of an Escherichia Coli (E. coli) fed-batch fermentation process. In contrast to conventional (static), data-driven multi-class machine learning (ML), we exploit process knowledge in order to constrain our classification system yielding more parsimonious models compared to static ML approaches. In particular, we enforce unidirectionality on a set of binary, multivariate classifiers trained to discriminate between adjacent feed phases by linking the classifiers through a one-way switch...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28734364/improved-variable-reduction-in-partial-least-squares-modelling-by-global-minimum-error-uninformative-variable-elimination
#17
Jan P M Andries, Yvan Vander Heyden, Lutgarde M C Buydens
The calibration performance of Partial Least Squares regression (PLS) can be improved by eliminating uninformative variables. For PLS, many variable elimination methods have been developed. One is the Uninformative-Variable Elimination for PLS (UVE-PLS). However, the number of variables retained by UVE-PLS is usually still large. In UVE-PLS, variable elimination is repeated as long as the root mean squared error of cross validation (RMSECV) is decreasing. The set of variables in this first local minimum is retained...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28734312/diffusion-quantum-monte-carlo-calculations-of-srfeo3-and-lafeo3
#18
Juan A Santana, Jaron T Krogel, Paul R C Kent, Fernando A Reboredo
The equations of state, formation energy, and migration energy barrier of the oxygen vacancy in SrFeO3 and LaFeO3 were calculated with the diffusion quantum Monte Carlo (DMC) method. Calculations were also performed with various Density Functional Theory (DFT) approximations for comparison. DMC reproduces the measured cohesive energies of these materials with errors below 0.23(5) eV and the structural properties within 1% of the experimental values. The DMC formation energies of the oxygen vacancy in SrFeO3 and LaFeO3 under oxygen-rich conditions are 1...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28734295/estimating-the-intrinsic-limit-of-the-feller-peterson-dixon-composite-approach-when-applied-to-adiabatic-ionization-potentials-in-atoms-and-small-molecules
#19
David Feller
Benchmark adiabatic ionization potentials were obtained with the Feller-Peterson-Dixon (FPD) theoretical method for a collection of 48 atoms and small molecules. In previous studies, the FPD method demonstrated an ability to predict atomization energies (heats of formation) and electron affinities well within a 95% confidence level of ±1 kcal/mol. Large 1-particle expansions involving correlation consistent basis sets (up to aug-cc-pV8Z in many cases and aug-cc-pV9Z for some atoms) were chosen for the valence CCSD(T) starting point calculations...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28734285/extension-of-the-d3-dispersion-coefficient-model
#20
Eike Caldeweyher, Christoph Bannwarth, Stefan Grimme
A new model, termed D4, for the efficient computation of molecular dipole-dipole dispersion coefficients is presented. As in the related, well established D3 scheme, these are obtained as a sum of atom-in-molecule dispersion coefficients over atom pairs. Both models make use of dynamic polarizabilities obtained from first-principles time-dependent density functional theory calculations for atoms in different chemical environments employing fractional atomic coordination numbers for interpolation. Different from the D3 model, the coefficients are obtained on-the-fly by numerical Casimir-Polder integration of the dynamic, atomic polarizabilities α(iω)...
July 21, 2017: Journal of Chemical Physics
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