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https://www.readbyqxmd.com/read/28549298/divided-consumption-of-late-night-dinner-improves-glycemic-excursions-in-patients-with-type-2-diabetes-a-randomized-cross-over-clinical-trial
#1
Saeko Imai, Shizuo Kajiyama, Yoshitaka Hashimoto, Chikako Yamane, Takashi Miyawaki, Neiko Ozasa, Muhei Tanaka, Michiaki Fukui
AIMS: To explore the acute effect of late-night-dinner and divided dinner on postprandial glucose levels in patients with type 2 diabetes. METHODS: Sixteen patients were randomly assigned to this cross-over study. Each patient wore a continuous glucose monitor for 5days and consumed identical test meals for 3days. Patients consumed the test meals of dinner at 2100h (D21) or divided dinner (vegetable and rice at 1800h and the vegetable and the main dish at 2100h) on the second or fourth day, and dinner at 1800h (D18) on the third day...
May 16, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28549277/reliability-of-lower-limb-transcranial-magnetic-stimulation-outcomes-in-the-ipsi-and-contralesional-hemispheres-of-adults-with-chronic-stroke
#2
Louis-David Beaulieu, Hugo Massé-Alarie, Edith Ribot-Ciscar, Cyril Schneider
OBJECTIVE: To investigate the ability of transcranial magnetic stimulation (TMS) outcomes in the chronic stroke population to (i) track individual plastic changes and (ii) detect differences between individuals. To this end, intrarater "test-retest" reliability (relative and absolute) was tested for the ipsilesional and contralesional hemispheres. METHODS: Thirteen participants with a unilateral stroke (≥6months ago) and sensorimotor impairments were enrolled...
May 9, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28549246/the-usage-of-data-compression-for-the-background-estimation-of-electron-energy-loss-spectra
#3
Jakob Spiegelberg, Ján Rusz, Klaus Leifer, Thomas Thersleff
Quantitative analysis of noisy electron spectrum images requires a robust estimation of the underlying background signal. We demonstrate how modern data compression methods can be used as a tool for achieving an analysis result less affected by statistical errors or to speed up the background estimation. In particular, we demonstrate how a multilinear singular value decomposition (MLSVD) can be used to enhance elemental maps obtained from a complex sample measured with energy electron loss spectroscopy. Furthermore, the usage of vertex component analysis (VCA) for a basis vector centered estimation of the background is demonstrated...
May 20, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28549209/genotypic-correlation-and-path-analysis-in-early-and-super-early-maize-genotypes
#4
B M Alves, A Cargnelutti Filho
The aims of this study were to assess the linear relationships between agronomic and nutritional traits and to identify promising traits for indirect selection in early and super-early maturing maize genotypes. Two trials were run in the 2009/2010 agricultural year, each consisting of a randomized block design with three replications. One trial was run on 36 early maturing maize genotypes and the other on 22 super-early maturing genotypes. Six agronomic traits, 11 protein-nutritional traits, and four energetic-nutritional traits were measured...
May 25, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28549092/the-effect-of-spectacle-lenses-containing-peripheral-defocus-on-refractive-error-and-horizontal-eye-shape-in-the-guinea-pig
#5
Hannah E Bowrey, Guang Zeng, Dennis Y Tse, Amelia J Leotta, Yi Wu, Chi-Ho To, Christine F Wildsoet, Sally A McFadden
Purpose: It has been proposed that the peripheral retina, responding to local optical defocus, contributes to myopia and associated altered eye growth in humans. To test this hypothesis, we measured the changes in central (on-axis) and peripheral ocular dimensions in guinea pigs wearing a concentric bifocal spectacle lens design with power restricted to the periphery. Methods: Five groups of guinea pigs (n = 83) wore either a unifocal (UF) spectacle lens (-4, 0, or +4 Diopters [D]), or a peripheral defocus (PF) spectacle lens that had a plano center (diameter of 5 mm) with either -4 or +4 D in the surround (-4/0 or +4/0 D)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28549082/pharmacokinetics-and-pharmacodynamics-of-propofol-changes-in-patients-with-frontal-brain-tumours
#6
M M Sahinovic, D J Eleveld, T Miyabe-Nishiwaki, M M R F Struys, A R Absalom
Background: Models of propofol pharmacokinetics and pharmacodynamics developed in patients without brain pathology are widely used for target-controlled infusion (TCI) during brain tumour excision operations. The goal of this study was to determine if the presence of a frontal brain tumour influences propofol pharmacokinetics and pharmacodynamics and existing PK-PD model performance. Methods: Twenty patients with a frontal brain tumour and 20 control patients received a propofol infusion to achieve an induction-emergence-induction anaesthetic sequence...
May 26, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28548919/a-novel-method-for-quanitifying-comfort-in-child-passengers-demonstrates-an-association-between-child-restraint-comfort-and-errors-in-use-of-booster-seats
#7
Cameron K Fong, Lynne E Bilston, Gunther Paul, Julie Brown
OBJECTIVE: Misuse of child restraint systems is a widespread and long-standing problem impacting risk of injury and death in car crashes. Discomfort has been suggested as a causative factor for misuse, particularly in errors introduced by children while they use the restraints. However, the relationship between comfort and errors in use has never been studied. In this study we examine the reliability and sensitivity of a newly developed observational method for assessing comfort in children in vehicles...
May 29, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28548697/metastatic-angiosarcoma-arising-in-malignant-peripheral-nerve-sheath-tumor-in-a-young-patient-with-neurofibromatosis-type-1
#8
Amanda C Winters, Jennifer O Black, Carrye R Cost
Neurofibromatosis type 1 (NF1) is a cancer predisposition syndrome with an incidence of approximately one in 3,000 and a lifetime risk of malignancy estimated at 8-13%. Here, we report the case of a patient with NF1 who developed synchronous malignant peripheral nerve sheath tumors, one with a focus of angiosarcoma. He succumbed to metastatic angiosarcoma despite local resection and adjuvant chemotherapy. This case highlights the need for monitoring for malignancy in NF1 patients, the risks of sampling error during tumor biopsy, and the clinical decision - making involved in choosing a therapeutic plan for a patient with multiple simultaneous malignancies...
May 26, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28548646/prevalence-and-the-risk-factors-for-visual-impairment-in-age-related-macular-degeneration
#9
S Srinivasan, G Swaminathan, V Kulothungan, R Raman, T Sharma
PurposeTo characterize the type, and the causes of visual impairment (VI) in various stages of early and late age-related macular degeneration (AMD) and the factors associated with visual impairment in subjects with AMDMethods6617 subjects ≥60 years were enumerated; 5495 (83.04%) participated in eye examination. Of which, 4791 subjects had gradable fundus images. AMD was graded per International ARM Epidemiological Study Group. Subjects underwent detailed ophthalmic exam. VI was defined per the WHO classification...
May 26, 2017: Eye
https://www.readbyqxmd.com/read/28548557/further-examination-of-embedded-performance-validity-indicators-for-the-conners-continuous-performance-test-and-brief-test-of-attention-in-a-large-outpatient-clinical-sample
#10
Michael J Sharland, Stephen C Waring, Brian P Johnson, Allise M Taran, Travis A Rusin, Andrew M Pattock, Jeanette A Palcher
OBJECTIVE: Assessing test performance validity is a standard clinical practice and although studies have examined the utility of cognitive/memory measures, few have examined attention measures as indicators of performance validity beyond the Reliable Digit Span. The current study further investigates the classification probability of embedded Performance Validity Tests (PVTs) within the Brief Test of Attention (BTA) and the Conners' Continuous Performance Test (CPT-II), in a large clinical sample...
May 26, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28548315/aapm-medical-physics-practice-guideline-8-a-linear-accelerator-performance-tests
#11
Koren Smith, Peter Balter, John Duhon, Gerald A White, David L Vassy, Robin A Miller, Christopher F Serago, Lynne A Fairobent
PURPOSE: The purpose of this guideline is to provide a list of critical performance tests in order to assist the Qualified Medical Physicist (QMP) in establishing and maintaining a safe and effective quality assurance (QA) program. The performance tests on a linear accelerator (linac) should be selected to fit the clinical patterns of use of the accelerator and care should be given to perform tests which are relevant to detecting errors related to the specific use of the accelerator. METHODS: A risk assessment was performed on tests from current task group reports on linac QA to highlight those tests that are most effective at maintaining safety and quality for the patient...
May 26, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28548299/a-noninvasive-diagnosis-of-hepatic-fibrosis-by-biofibroscore%C3%A2-in-chronic-hepatitis-c-patients
#12
Chen-Hua Liu, Chun-Jen Liu, Chun-Ming Hong, Tung-Hung Su, Hung-Chih Yang, Kuei-Ming Chen, Yi-Ping Huang, Yu-Ming Yeh, Hui-Lan Tien, Yuan-Chih Liu, Jia-Horng Kao, Ding-Shinn Chen, Pei-Jer Chen
BACKGROUND & AIMS: The diagnostic accuracy of a novel serological panel (BioFibroScore®) to predict hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection is unknown. METHODS: Three markers of BioFibroScore®, including urokinase plasminogen activator (uPA), matrix metalloproteinase-9 (MMP-9), and beta-2 microglobulin (β2M), were retrospectively evaluated in 635 HCV-infected patients who received percutaneous liver biopsy and FibroScan®. The formula of BioFibroScore® to predict the severity of hepatic fibrosis was developed by Adaboost algorithm...
May 26, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28548120/early-barrett-esophagus-related-neoplasia-in-segments-1%C3%A2-cm-or-longer-is-always-associated-with-intestinal-metaplasia
#13
Benjamin Michael Allanson, Jessica Bonavita, Bob Mirzai, Tze Sheng Khor, Spiro C Raftopoulos, Willem Bastiaan de Boer, Ian S Brown, Marian Priyanthi Kumarasinghe
The assumption that intestinal metaplasia is a prerequisite for intraepithelial neoplasia/dysplasia and adenocarcinoma in the distal esophagus has been challenged by observations of adenocarcinoma without associated intestinal metaplasia. This study describes our experience of intestinal metaplasia in association with early Barrett neoplasia in distal esophagus and gastroesophageal junction. We reviewed the first endoscopic mucosal resection of 139 patients with biopsy-proven neoplasia. In index endoscopic mucosal resection, 110/139 (79%) cases showed intestinal metaplasia...
May 26, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28548052/optimizing-the-stimulus-presentation-paradigm-design-for-the-p300-based-brain-computer-interface-using-performance-prediction
#14
Boyla Mainsah, Galen Reeves, Leslie Collins, Chandra Throckmorton
<i>Objective:</i> The role of a brain-computer interface (BCI) is to discern a user's intended message by extracting and decoding relevant information from brain signals. Stimulus-driven BCIs, such as the P300 speller, rely on detecting event-related potentials (ERPs) in response to a user attending to relevant or target stimulus events. However, this process is error-prone because the ERPs are embedded in noisy electroencephalography (EEG) data, representing a fundamental problem in communication of the uncertainty in the information that is received during noisy transmission...
May 26, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28547882/re-adjusting-the-cut-off-score-of-the-korean-version-of-the-childhood-autism-rating-scale-for-high-functioning-individuals-with-autism-spectrum-disorder
#15
Hyuk-Jin Kwon, Hee-Jeong Yoo, Joo-Hyun Kim, Dong-Hyun Noh, Hyun-Jung Sunwoo, Ye Seul Jeon, Sang-Youn Lee, Ye-Ul Jo, Gui-Young Bong
AIM: The current cut-off score of the Korean version of the Childhood Autism Rating Scale(K-CARS) does not seem sensitive enough to precisely diagnose high-functioning autism. The aim of this study was to identify the optimal cut-off score of K-CARS for diagnosing high-functioning individuals with Autism Spectrum Disorders(ASD). METHODS: A total of 329 participants were assessed by the Korean versions of the Autism Diagnostic Interview - Revised (K-ADI-R), Autism Diagnostic Observation Schedule (K-ADOS), and K-CARS...
May 26, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28547838/more-efficient-parameter-estimates-for-factor-analysis-of-ordinal-variables-by-ridge-generalized-least-squares
#16
Ke-Hai Yuan, Ge Jiang, Ying Cheng
Data in psychology are often collected using Likert-type scales, and it has been shown that factor analysis of Likert-type data is better performed on the polychoric correlation matrix than on the product-moment covariance matrix, especially when the distributions of the observed variables are skewed. In theory, factor analysis of the polychoric correlation matrix is best conducted using generalized least squares with an asymptotically correct weight matrix (AGLS). However, simulation studies showed that both least squares (LS) and diagonally weighted least squares (DWLS) perform better than AGLS, and thus LS or DWLS is routinely used in practice...
May 26, 2017: British Journal of Mathematical and Statistical Psychology
https://www.readbyqxmd.com/read/28547735/the-burden-of-headache-disorders-in-ethiopia-national-estimates-from-a-population-based-door-to-door-survey
#17
Mehila Zebenigus, Redda Tekle-Haimanot, Dawit K Worku, Hallie Thomas, Timothy J Steiner
BACKGROUND: Headache disorders are the third-highest cause of disability worldwide, with migraine and medication-overuse headache (MOH) the major contributors. In Ethiopia we have shown these disorders to be highly prevalent: migraine 17.7%, TTH 20.6%, probable MOH (pMOH) 0.7%, any headache yesterday (HY) 6.4%. To inform local health policy, we now estimate disability and other burdens attributable to headache in this country. METHODS: In a cross-sectional survey using cluster-randomized sampling, we visited households unannounced in four diverse regions (urban and rural) of Ethiopia...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28547182/three-year-survival-of-art-high-viscosity-glass-ionomer-and-resin-composite-restorations-in-people-with-disability
#18
Gustavo F Molina, Denise Faulks, Ignacio Mazzola, Ricardo J Cabral, Jan Mulder, Jo E Frencken
OBJECTIVES: To assess the 3-year cumulative survival rate of atraumatic restorative treatment (ART) and conventional resin composite restorations (CRT) placed in persons with disability. MATERIALS AND METHODS: Patients referred for restorative care to the Haemophilia Foundation special care service were treated by one of two specialists. Patients and/or caregivers were provided with written and verbal information regarding treatment options and selected the alternative they preferred...
May 25, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28547180/role-of-antioxidant-treatment-on-dna-and-lipid-damage-in-the-brain-of-rats-subjected-to-a-chemically-induced-chronic-model-of-tyrosinemia-type-ii
#19
Emilio L Streck, Samira D T De Prá, Paula Ronsani Ferro, Milena Carvalho-Silva, Lara M Gomes, Jotele F Agostini, Adriani Damiani, Vanessa M Andrade, Patrícia F Schuck, Gustavo C Ferreira, Giselli Scaini
Tyrosine levels are abnormally elevated in tissues and body fluids of patients with inborn errors of tyrosine metabolism. Tyrosinemia type II, which is caused by tyrosine aminotransferase deficiency, provokes eyes, skin, and central nervous system disturbances in affected patients. However, the mechanisms of brain damage are still poorly known. Considering that studies have demonstrated that oxidative stress may contribute, along with other mechanisms, to the neurological dysfunction characteristic of hypertyrosinemia, in the present study we investigated the effects of antioxidant treatment (NAC and DFX) on DNA damage and oxidative stress markers induced by chronic administration of L-tyrosine in cerebral cortex, hippocampus, and striatum of rats...
May 25, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28547127/the-relationship-between-outcome-prediction-and-cognitive-fatigue-a-convergence-of-paradigms
#20
G R Wylie, H M Genova, J DeLuca, E Dobryakova
Cognitive fatigue is common after strenuous cognitive effort. A large body of literature has implicated a network of brain areas in fatigue, including the basal ganglia and cortical areas including ventro-medal prefrontal cortex and anterior cingulate cortex (ACC). Furthermore, the ACC has been shown to be involved in processes such as error and conflict monitoring, outcome prediction, and effort processing. Thus, the ACC appears to be one common denominator between clinical work on fatigue and research on outcome prediction and effort...
May 25, 2017: Cognitive, Affective & Behavioral Neuroscience
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