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https://www.readbyqxmd.com/read/29458099/using-near-infrared-spectroscopy-to-predict-the-lignin-content-and-monosaccharide-compositions-of-pinus-radiata-wood-cell-walls
#1
Leona M Fahey, Michél K Nieuwoudt, Philip J Harris
Near infrared (NIR) spectroscopy coupled with partial least squares (PLS-1) regression was used to predict the lignin contents and monosaccharide compositions of milled wood of Pinus radiata. The effects of particle size and moisture content were investigated by collecting NIR spectra of four sample types: large (<0.422 mm) and small (<0.178 mm) particles, in both ambient and dry conditions. PLS-1 models were constructed using mixtures of compression wood (CW) and opposite wood (OW) that provided a linear range of cell-wall compositions...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29458074/subthalamic-nucleus-stimulation-dopaminergic-treatment-and-impulsivity-in-parkinson-s-disease
#2
Frédérique Fluchère, Borís Burle, Franck Vidal, Wery van den Wildenberg, Tatiana Witjas, Alexandre Eusebio, Jean-Philippe Azulay, Thierry Hasbroucq
BACKGROUND: Deep brain stimulation of the subthalamic nucleus (STN DBS) is known to increase response speed and lower response accuracy in Parkinson's disease (PD) patients. It has been proposed that this speed-accuracy tradeoff is due to enhanced sensitivity of the motor system to sensory information. An alternative possibility is that this effect is due to weakened suppressive processes. The two alternative interpretations can be tested by analyzing the electromyographic activity (EMG) of the response agonists when the patients perform conflict reaction time tasks...
February 16, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29458028/are-portable-stereophotogrammetric-devices-reliable-in-facial-imaging-a-validation-study-of-vectra-h1-device
#3
Daniele Gibelli, Valentina Pucciarelli, Annalisa Cappella, Claudia Dolci, Chiarella Sforza
PURPOSE: Modern 3-dimensional (3D) image acquisition systems represent a crucial technologic development in facial anatomy because of their accuracy and precision. The recently introduced portable devices can improve facial databases by increasing the number of applications. In the present study, the VECTRA H1 portable stereophotogrammetric device was validated to verify its applicability to 3D facial analysis. MATERIALS AND METHODS: Fifty volunteers underwent 4 facial scans using portable VECTRA H1 and static VECTRA M3 devices (2 for each instrument)...
January 31, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29457969/an-evaluation-of-the-operational-model-when-applied-to-quantify-functional-selectivity
#4
Xiao Zhu, David B Finlay, Michelle Glass, Stephen B Duffull
BACKGROUND AND PURPOSE: Functional selectivity describes the ability of ligands to differentially regulate multiple signalling pathways when coupled to a single receptor and the operational model is commonly used to analyse these data. Here, we assess the mathematical properties of the operational model and evaluate the impact of fixing parameters on model performance. EXPERIMENTAL APPROACH: The operational model was evaluated using both a mathematical identifiability analysis and simulation...
February 19, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29457795/random-access-in-large-scale-dna-data-storage
#5
Lee Organick, Siena Dumas Ang, Yuan-Jyue Chen, Randolph Lopez, Sergey Yekhanin, Konstantin Makarychev, Miklos Z Racz, Govinda Kamath, Parikshit Gopalan, Bichlien Nguyen, Christopher N Takahashi, Sharon Newman, Hsing-Yeh Parker, Cyrus Rashtchian, Kendall Stewart, Gagan Gupta, Robert Carlson, John Mulligan, Douglas Carmean, Georg Seelig, Luis Ceze, Karin Strauss
Synthetic DNA is durable and can encode digital data with high density, making it an attractive medium for data storage. However, recovering stored data on a large-scale currently requires all the DNA in a pool to be sequenced, even if only a subset of the information needs to be extracted. Here, we encode and store 35 distinct files (over 200 MB of data), in more than 13 million DNA oligonucleotides, and show that we can recover each file individually and with no errors, using a random access approach. We design and validate a large library of primers that enable individual recovery of all files stored within the DNA...
February 19, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29457751/intra-and-inter-fraction-uncertainties-during-igrt-for-wilms-tumor
#6
Filipa Guerreiro, Enrica Seravalli, Geert O Janssens, Cees P van de Ven, Marry M van den Heuvel-Eibrink, Bas W Raaymakers
BACKGROUND AND PURPOSE: To assess intra- and inter-fraction motion uncertainties, due to displacements of the tumor bed (TB) and organs at risk (OAR), as well as intra- and inter-fraction patient set-up uncertainties, due to positioning variations, during image-guided radiation therapy (IGRT) in children with Wilms' tumor. MATERIAL AND METHODS: Four-dimensional computed tomography (4D-CT) and daily pre- and post-treatment cone-beam CT (CBCT)-scans of 15 patients (average 4, range 1-8 years) undergoing flank irradiation after nephrectomy were analyzed...
February 19, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29457585/training-nurses-in-a-competency-framework-to-support-adults-with-epilepsy-and-intellectual-disability-the-epaid-cluster-rct
#7
Howard Ring, James Howlett, Mark Pennington, Christopher Smith, Marcus Redley, Caroline Murphy, Roxanne Hook, Adam Platt, Nakita Gilbert, Elizabeth Jones, Joanna Kelly, Angela Pullen, Adrian Mander, Cam Donaldson, Simon Rowe, James Wason, Fiona Irvine
BACKGROUND: People with an intellectual (learning) disability (ID) and epilepsy have an increased seizure frequency, higher frequencies of multiple antiepileptic drug (AED) use and side effects, higher treatment costs, higher mortality rates and more behavioural problems than the rest of the population with epilepsy. The introduction of nurse-led care may lead to improvements in outcome for those with an ID and epilepsy; however, this has not been tested in a definitive clinical trial...
February 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29457556/is-markedness-a-confused-concept
#8
Iris Berent
It is well known that, across languages, certain phonological features are more frequent than others. But whether these facts reflect abstract universal markedness constraints or functional pressures (auditory and articulatory difficulties and lexical frequency) is unknown. Romani, Galuzzi, Guariglia, and Goslin (2017) report that the putative markedness of phonological features captures their order of acquisition and their propensity to elicit errors in patients with an apraxia of speech (but not in phonological aphasia)...
October 2017: Cognitive Neuropsychology
https://www.readbyqxmd.com/read/29457555/encoding-of-distributional-regularities-independent-of-markedness-evidence-from-unimpaired-speakers
#9
Matthew Goldrick
Romani, Galuzzi, Guariglia, and Goslin (Comparing phoneme frequency, age of acquisition and loss in aphasia: Implications for phonological universals. Cognitive Neuropsychology) used speech error data from individuals with acquired impairments to argue that independent from articulatory complexity, within-language distributional regularities influence the processing of sound structure in speech production. Converging evidence from unimpaired speakers is reviewed, focusing on speech errors in language production...
October 2017: Cognitive Neuropsychology
https://www.readbyqxmd.com/read/29457553/the-difficulty-of-articulatory-complexity
#10
Marianne Pouplier, Stefania Marin, Alexei Kochetov
In our commentary, we offer some support for the view that frequency rather than a language-independent definition of complexity is a main factor determining speech production in healthy adults. We further discuss the limits of defining articulatory complexity based on transcription data. If we want to gauge the impact of substantive constraints on speech production, context-specific production dynamics should be considered, as has been underscored by articulatory-acoustic work on speech errors.
October 2017: Cognitive Neuropsychology
https://www.readbyqxmd.com/read/29457337/a-novel-rotational-matrix-and-translation-vector-algorithm-geometric-accuracy-for-augmented-reality-in-oral-and-maxillofacial-surgeries
#11
Yahini Prabha Murugesan, Abeer Alsadoon, Paul Manoranjan, P W C Prasad
BACKGROUND: Augmented reality-based surgeries have not been successfully implemented in oral and maxillofacial areas due to limitations in geometric accuracy and image registration. This paper aims to improve the accuracy and depth perception of the augmented video. METHODOLOGY: The proposed system consists of a rotational matrix and translation vector algorithm to reduce the geometric error and improve the depth perception by including 2 stereo cameras and a translucent mirror in the operating room...
February 19, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29457319/the-impact-of-b-1-correction-on-mp2rage-cortical-t-1-and-apparent-cortical-thickness-at-7t
#12
Roy A M Haast, Dimo Ivanov, Kâmil Uludağ
Determination of cortical thickness using MRI has often been criticized due to the presence of various error sources. Specifically, anatomical MRI relying on T1 contrast may be unreliable due to spatially variable image contrast between gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF). Especially at ultra-high field (≥ 7T) MRI, transmit and receive B1 -related image inhomogeneities can hamper correct classification of tissue types. In the current paper, we demonstrate that residual B1+ (transmit) inhomogeneities in the T1 -weighted and quantitative T1 images using the MP2RAGE sequence at 7T lead to biases in cortical thickness measurements...
February 18, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29457313/modeling-the-hematocrit-distribution-in-microcirculatory-networks-a-quantitative-evaluation-of-a-phase-separation-model
#13
Peter M Rasmussen, Timothy W Secomb, Axel R Pries
OBJECTIVE: Theoretical models are essential tools for studying microcirculatory function. Recently, the validity of a well-established phase separation model was questioned and it was claimed that it produces problematically low hematocrit predictions and lack of red cells in small diameter vessels. We conducted a quantitative evaluation of this phase separation model to establish common ground for future research. METHODS: Model predictions were validated against a comprehensive data base with measurements from four mesenteric networks...
February 19, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29457309/severe-intestinal-malabsorption-associated-with-ace-inhibitor-or-angiotensin-receptor-blocker-treatment-an-observational-cohort-study-in-germany-and-italy
#14
Peter Malfertheiner, Claudio Ripellino, Nazarena Cataldo
PURPOSE: The angiotensin II receptor blocker (ARB) olmesartan has been recently associated with sprue-like enteropathy (SLE), a gastrointestinal condition characterized by intestinal malabsorption (IM) and severe diarrhea. Whether the increased risk of SLE is substance-specific or a class effect involving all ARBs is uncertain. The aim of this study is to assess the risk of enteropathy associated with ARBs and angiotensin converting enzyme inhibitors (ACE-i) by using data from large administrative and claim databases...
February 19, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29457287/zero-te-based-pseudo-ct-image-conversion-in-the-head-and-its-application-in-pet-mr-attenuation-correction-and-mr-guided-radiation-therapy-planning
#15
Florian Wiesinger, Mikael Bylund, Jaewon Yang, Sandeep Kaushik, Dattesh Shanbhag, Sangtae Ahn, Joakim H Jonsson, Josef A Lundman, Thomas Hope, Tufve Nyholm, Peder Larson, Cristina Cozzini
PURPOSE: To describe a method for converting Zero TE (ZTE) MR images into X-ray attenuation information in the form of pseudo-CT images and demonstrate its performance for (1) attenuation correction (AC) in PET/MR and (2) dose planning in MR-guided radiation therapy planning (RTP). METHODS: Proton density-weighted ZTE images were acquired as input for MR-based pseudo-CT conversion, providing (1) efficient capture of short-lived bone signals, (2) flat soft-tissue contrast, and (3) fast and robust 3D MR imaging...
February 18, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29457253/power-transformations-improve-interpolation-of-grids-for-molecular-mechanics-interaction-energies
#16
David D L Minh
A common strategy for speeding up molecular docking calculations is to precompute nonbonded interaction energies between a receptor molecule and a set of three-dimensional grids. The grids are then interpolated to compute energies for ligand atoms in many different binding poses. Here, I evaluate a smoothing strategy of taking a power transformation of grid point energies and inverse transformation of the result from trilinear interpolation. For molecular docking poses from 85 protein-ligand complexes, this smoothing procedure leads to significant accuracy improvements, including an approximately twofold reduction in the root mean square error at a grid spacing of 0...
February 18, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29457248/duty-hours-restriction-for-our-surgical-trainees-an-ethical-obligation-or-a-bad-idea
#17
REVIEW
Christopher A Adin, Callie A Fogle, Steven L Marks
To ensure patient safety and protect the well-being of interns and residents, the Accreditation Council for Graduate Medical Education (ACGME) issued guidelines in 2003 limiting the working hours of physician trainees. Although many supported the goals of the ACGME, institutions struggled to restructure their programs and hire staff required by this unfunded mandate. Numerous studies have analyzed the effects of duty hours restrictions on patient outcomes and physician training over the past 15 years. Most agree that duty hours restrictions improved well-being of house officers, but these improvements came at the expense of continuity, and patient hand-offs led to medical errors...
February 19, 2018: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29457192/influence-of-orthodontic-appliance-derived-artifacts-on-3-t-mri-movies
#18
Erika Ozawa, Ei-Ichi Honda, Kulthida Nunthayanon Parakonthun, Hiroko Ohmori, Kazuo Shimazaki, Tohru Kurabayashi, Takashi Ono
BACKGROUND: Magnetic resonance imaging (MRI) has been used to study configurations of speech organs in the resting state. However, MRI is sensitive to metals, and numerous types of metallic appliances, most of which have a large magnetic susceptibility, are used in orthodontic treatment and may cause severe artifacts on MRI. We have developed techniques for obtaining MRI movies of the oral region, to evaluate articulatory changes, especially movement of the tongue, palate, and teeth, pre- and post-orthodontic/orthognathic treatment...
February 19, 2018: Progress in Orthodontics
https://www.readbyqxmd.com/read/29456580/the-accuracy-of-ultrasound-estimation-of-fetal-weight-in-comparison-to-birth-weight-a-systematic-review
#19
Julia Milner, Jane Arezina
Ultrasound estimation of fetal weight is a highly influential factor in antenatal management, guiding both the timing and mode of delivery of a pregnancy. Although substantial research has investigated the most accurate ultrasound formula for calculating estimated fetal weight, current evidence indicates significant error levels. The aim of this systematic review was to identify the most accurate method, whilst identifying sources of inaccuracy in order to facilitate recommendations for future practice. Seven studies met the inclusion criteria and 11 different formulae were assessed; ultrasound calculation of fetal weight was most commonly overestimated...
February 2018: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/29456501/recommendations-for-the-design-of-serious-games-in-neurodegenerative-diseases
#20
Grégory Ben-Sadoun, Valeria Manera, Julian Alvarez, Guillaume Sacco, Philippe Robert
The use of Serious Games (SG) in the health domain is expanding. In the field of Neurodegenerative Diseases (ND) such as Alzheimer's Disease, SG are currently employed to provide alternative solutions for patients' treatment, stimulation, and rehabilitation. The design of SG for people with ND implies collaborations between professionals in ND and professionals in SG design. As the field is quite young, professionals specialized in both ND and SG are still rare, and recommendations for the design of SG for people with ND are still missing...
2018: Frontiers in Aging Neuroscience
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