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https://www.readbyqxmd.com/read/28339995/long-term-flecainide-therapy-in-type-3-long-qt-syndrome
#1
Ehud Chorin, Rivki Taub, Aron Medina, Nir Flint, Sami Viskin, Jesaia Benhorin
Aims: Type 3 long QT syndrome (LQT3) is caused by gain-of-function mutations in the cardiac sodium channel gene (SCN5A). Previous reports on the long-term use of sodium channel blockers in LQT3 are sparse. The objective of the current study was to evaluate the long-term safety and efficacy of flecainide therapy in patients with LQT3 who carry the D1790G SCN5A mutation. Methods and results: The study population comprised 30 D1790G carriers who were treated with flecainide and followed for 1-215 months (mean 145 ± 54 months, median 140 months)...
February 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339120/accessing-structurally-diverse-near-infrared-cyanine-dyes-for-folate-receptor-targeted-cancer-cell-staining
#2
Sandra G König, Roland Krämer
Folate receptor (FR) targeting is one of the most promising strategies for the development of small-molecule based cancer imaging agents since the FR is highly overexpressed on the surface of many cancer cell types. FR-targeted conjugates of NIR emissive cyanine dyes are in advanced clinical trials for fluorescence-guided surgery and are valuable research tools for optical molecular imaging in animal models. Only a small number of promising conjugates has been evaluated so far. Analysis of structure-performance relations to identify critical factors modulating the performance of targeted conjugates is essential for successful further optimization...
March 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28338291/versatile-polymer-nanoparticles-as-two-photon-triggered-photosensitizers-for-simultaneous-cellular-deep-tissue-imaging-and-photodynamic-therapy
#3
Liang Guo, Jiechao Ge, Qian Liu, Qingyan Jia, Hongyan Zhang, Weimin Liu, Guangle Niu, Sha Liu, Jianru Gong, Steffen Hackbarth, Pengfei Wang
Clinical applications of current photodynamic therapy (PDT) photosensitizers (PSs) are often limited by their absorption in the UV-vis range that possesses limited tissue penetration ability, leading to ineffective therapeutic response for deep-seated tumors. Alternatively, two-photon excited PS (TPE-PS) using NIR light triggered is one the most promising candidates for PDT improvement. Herein, multimodal polymer nanoparticles (PNPs) from polythiophene derivative as two-photon fluorescence imaging as well as two-photon-excited PDT agent are developed...
March 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28338071/phase-transition-nanodroplets-for-real-time-photoacoustic-ultrasound-dual-modality-imaging-and-photothermal-therapy-of-sentinel-lymph-node-in-breast-cancer
#4
Lu Yang, Juan Cheng, Yuli Chen, Shengjie Yu, Fengqiu Liu, Yang Sun, Yu Chen, Haitao Ran
Pathological status of lymph nodes (LNs) plays a critical role in staging and treatment for the patients with breast cancer. Sentinel lymph node biopsy has become the standard method in determining pathological status of axillary LNs. Therefore, the determination of sentinel lymph nodes (SLNs) and therapy of metastatic LNs are highly desirable in clinic. Herein, an unprecedented carbon nanoparticles (CNs)-incorporated liquid-gas phase-transition nanodroplets (CNPs) with strong near-infrared (NIR) absorption, good biocompatibility, excellent photoacoustic (PA) and ultrasound (US) contrast, and high photothermal-conversion efficiency are reported in this study...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28338043/redshifted-cherenkov-radiation-for-in-vivo-imaging-coupling-cherenkov-radiation-energy-transfer-to-multiple-f%C3%A3-rster-resonance-energy-transfers
#5
Yann Bernhard, Bertrand Collin, Richard A Decréau
Cherenkov Radiation (CR), this blue glow seen in nuclear reactors, is an optical light originating from energetic β-emitter radionuclides. CR emitter (90)Y triggers a cascade of energy transfers in the presence of a mixed population of fluorophores (which each other match their respective absorption and emission maxima): Cherenkov Radiation Energy Transfer (CRET) first, followed by multiple Förster Resonance Energy transfers (FRET): CRET ratios were calculated to give a rough estimate of the transfer efficiency...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337322/platinum-ii-ring-fused-chlorins-as-near-infrared-emitting-oxygen-sensors-and-photodynamic-agents
#6
Nelson A M Pereira, Mafalda Laranjo, João Casalta-Lopes, Arménio C Serra, Marta Piñeiro, João Pina, J Sérgio Seixas de Melo, Mathias O Senge, M Filomena Botelho, Liliana Martelo, Hugh D Burrows, Teresa M V D Pinho E Melo
Novel near-infrared luminescent compounds based on platinum(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins are described. These compounds have high photostability and display light emission, in particular simultaneous fluorescence and phosphorescence emission in solution at room temperature, in the biologically relevant 700-850 nm red and near-infrared (NIR) spectral region, making them excellent materials for biological imaging. The simultaneous presence of fluorescence and phosphorescence emission at room temperature, with the phosphorescence strongly quenched by oxygen whereas fluorescence remains unaffected, allows these compounds to be used as ratiometric oxygen sensors in chemical and biological media...
March 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28336927/combination-of-electroencephalography-and-near-infrared-spectroscopy-in-evaluation-of-mental-concentration-during-the-mental-focus-task-for-wisconsin-card-sorting-test
#7
Che-Wei Chen, Chia-Wei Sun
Near-infrared spectroscopy (NIRS) is a noninvasive neuroimaging tool for measuring evoked functional changes in brain oxygenation. Electroencephalography (EEG) can be used to evaluate the functionality of cortical connections and obtain information on regional cortical activity. Coregistration of EEG-NIRS is a recent technique that has been applied for measuring changes in electrical and hemodynamic activity in the human brain. EEG-NIRS coregistration facilitates the avoidance of misleading interpretations of NIRS, particularly in the diagnosis of neurological disorders...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28336901/an-optical-sensor-with-polyaniline-gold-hybrid-nanostructures-for-monitoring-ph-in-saliva
#8
Chongdai Luo, Yangyang Wang, Xuemeng Li, Xueqin Jiang, Panpan Gao, Kang Sun, Jianhua Zhou, Zhiguang Zhang, Qing Jiang
Saliva contains important personal physiological information that is related to some diseases, and it is a valuable source of biochemical information that can be collected rapidly, frequently, and without stress. In this article, we reported a new and simple localized surface plasmon resonance (LSPR) substrate composed of polyaniline (PANI)-gold hybrid nanostructures as an optical sensor for monitoring the pH of saliva samples. The overall appearance and topography of the substrates, the composition, and the wettability of the LSPR surfaces were characterized by optical and scanning electron microscope (SEM) images, infrared spectra, and contact angles measurement, respectively...
March 17, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28336508/using-web-based-search-data-to-study-the-public-s-reactions-to-societal-events-the-case-of-the-sandy-hook-shooting
#9
Nir Menachemi, Saurabh Rahurkar, Mandar Rahurkar
BACKGROUND: Internet search is the most common activity on the World Wide Web and generates a vast amount of user-reported data regarding their information-seeking preferences and behavior. Although this data has been successfully used to examine outbreaks, health care utilization, and outcomes related to quality of care, its value in informing public health policy remains unclear. OBJECTIVE: The aim of this study was to evaluate the role of Internet search query data in health policy development...
March 23, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28335550/preparation-of-biodegradable-and-elastic-poly-%C3%AE%C2%B5-caprolactone-co-lactide-copolymers-and-evaluation-as-a-localized-and-sustained-drug-delivery-carrier
#10
Ji Hoon Park, Bo Keun Lee, Seung Hun Park, Mal Geum Kim, Jin Woo Lee, Hye Yun Lee, Hai Bang Lee, Jae Ho Kim, Moon Suk Kim
To develop a biodegradable polymer possessing elasticity and flexibility, we synthesized MPEG-b-(PCL-co-PLA) copolymers (PCxLyA), which display specific rates of flexibility and elasticity. We synthesize the PCxLyA copolymers by ring-opening polymerization of ε-caprolactone and l-lactide. PCxLyA copolymers of various compositions were synthesized with 500,000 molecular weight. The PCxLyA copolymers mechanical properties were dependent on the mole ratio of the ε-caprolactone and l-lactide components. Cyclic tensile tests were carried out to investigate the resistance to creep of PCxLyA specimens after up to 20 deformation cycles to 50% elongation...
March 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28335291/multispectral-emissions-of-lanthanide-doped-gadolinium-oxide-nanophosphors-for-cathodoluminescence-and-near-infrared-upconversion-downconversion-imaging
#11
Doan Thi Kim Dung, Shoichiro Fukushima, Taichi Furukawa, Hirohiko Niioka, Takumi Sannomiya, Kaori Kobayashi, Hiroshi Yukawa, Yoshinobu Baba, Mamoru Hashimoto, Jun Miyake
Comprehensive imaging of a biological individual can be achieved by utilizing the variation in spatial resolution, the scale of cathodoluminescence (CL), and near-infrared (NIR), as favored by imaging probe Gd₂O₃ co-doped lanthanide nanophosphors (NPPs). A series of Gd₂O₃:Ln(3+)/Yb(3+) (Ln(3+): Tm(3+), Ho(3+), Er(3+)) NPPs with multispectral emission are prepared by the sol-gel method. The NPPs show a wide range of emissions spanning from the visible to the NIR region under 980 nm excitation. The dependence of the upconverting (UC)/downconverting (DC) emission intensity on the dopant ratio is investigated...
September 6, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334692/sers-active-liposome-ag-au-nanocomposite-for-nir-light-driven-drug-release
#12
Yangyang Zhao, Jing Zhao, Guiye Shan, Dongmei Yan, Yanwei Chen, Yichun Liu
It is important to control drug release and detect the distribution of drug molecules before and after release. In this work, liposome@AgAu nanocomposite is prepared for drug delivery, which not only can control drug release by near infrared laser irradiation but also can monitor drug molecules by surface enhanced Raman scattering (SERS) and fluorescence signal during the release process. The liposome@AgAu core/shell nanocomposite prepared by the galvanic replacement reaction (GRR) shows tunable localized surface plasmon resonance (LSPR) absorption peaks from visible to near-infrared region and good biocompatibility...
March 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28334690/intracellular-fluorescent-light-up-bioprobes-with-different-morphology-for-image-guided-photothermal-cancer-therapy
#13
Bangbang Li, Peng Zhang, Jianwei Du, Xiao Zhao, Youxiang Wang
Multifunctional nanoprobe was drawing increased attention in tumor diagnosis and therapy. The simple and effective establishment of the theranostic nanoplatforms was still under urgent need. Meanwhile, the targeting ability and morphology of nanoprobe were essential for the effective endocytosis, which could further affect the diagnosis. In this work, two morphologies of nanoprobes were fabricated using gold nanorods (AuNRs) and gold nanospheres (AuNSs). Thiolated-hyaluronic acid labeled with nile blue (HS-HA-NB), a near-infrared (NIR) fluorescence dye, was coated on the surface of the gold nanoparticles to form stable nanoprobes (AuNR@HS-HA-NB, AuNS@HS-HA-NB)...
March 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28334175/attenuated-fast-steady-state-visual-evoked-potentials-during-human-sleep
#14
Omer Sharon, Yuval Nir
During sleep, external sensory events rarely elicit a behavioral response or affect perception. However, how sensory processing differs between wakefulness and sleep remains unclear. A major difficulty in this field stems from using brief auditory stimuli that often trigger nonspecific high-amplitude "K-complex" responses and complicate interpretation. To overcome this challenge, here we delivered periodic visual flicker stimulation across sleep and wakefulness while recording high-density electroencephalography (EEG) in humans...
February 25, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28333708/cost-effectiveness-of-antihypertensive-medication-exploring-race-and-sex-differences-using-data-from-the-reasons-for-geographic-and-racial-differences-in-stroke-study
#15
Gabriel S Tajeu, Stephen Mennemeyer, Nir Menachemi, Robert Weech-Maldonado, Meredith Kilgore
BACKGROUND: Antihypertensive medication decreases risk of cardiovascular disease (CVD) events in adults with hypertension. Although black adults have higher prevalence of hypertension and worse CVD outcomes compared with whites, limited attention has been given to the cost-effectiveness of antihypertensive medication for blacks. OBJECTIVE: To compare the cost-effectiveness of antihypertensive medication treatment versus no-treatment in white and black adults. RESEARCH DESIGN: We constructed a State Transition Model to assess the costs and quality-adjusted life-years (QALYs) associated with either antihypertensive medication treatment or no-treatment using data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study and published literature...
March 22, 2017: Medical Care
https://www.readbyqxmd.com/read/28332977/a-new-way-to-build-cell-lineages
#16
Xiuwei Zhang, Nir Yosef
A combination of single-cell techniques and computational analysis enables the simultaneous discovery of cell states, lineage relationships and the genes that control developmental decisions.
March 23, 2017: ELife
https://www.readbyqxmd.com/read/28332676/application-of-the-dimensional-reduction-formalism-to-pb9-xbax-li2-p2o7-2-p4o13-2-x-0-2-6-7-a-series-of-phosphates-with-two-types-of-isolated-polyphosphate-groups
#17
Xiangyu Zhang, Hongping Wu, Qiong Liu, Xiaoyu Dong, Yunlei Chen, Zhihua Yang, Xiao-Dong Wen, Shilie Pan
A series of phosphates, Pb9-xBax[Li2(P2O7)2(P4O13)2] (x = 0, 2, 6, 7), have been synthesized by a high temperature solution method and the crystal structures were determined by single crystal X-ray diffraction. They are isostructural and crystallize in the triclinic space group P1[combining macron]. It is interesting that there are two kinds of isolated polyphosphate anionic groups coexisting in the crystal structure, which is rare among phosphates. Their structures exhibit zero-dimensional [Li2(P2O7)2(P4O13)2](18-) anionic clusters constructed by the LiO4, P2O7 and P4O13 groups, which are separated by the Pb(2+) or Ba(2+) cations...
March 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28332669/multiple-imaging-and-excellent-anticancer-efficiency-of-an-upconverting-nanocarrier-mediated-by-single-near-infrared-light
#18
Yan Wang, Guixin Yang, Yanli Wang, Yanping Zhao, Haizhi Jiang, Yuyan Han, Piaoping Yang
It is difficult to meet the requirements of clinical diagnosis through a single imaging technique. Similarly, satisfactory therapy efficacy is also hard to achieve by a single therapeutic modality. It is therefore highly desirable and interesting to simultaneously achieve multimodal imaging and therapies in one single structure. In this study, we developed a core-shell-satellite NaGdF4:Yb,Er,Mn,Co@mSiO2-CuS structure using up-conversion luminescent (UCL) NaGdF4:Yb,Er,Mn,Co as the core, mesoporous silica as the layer, and the photoactive CuS nanoparticles as the satellites...
March 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28331785/an-enhanced-uv-vis-nir-an-d-flexible-photodetector-based-on-electrospun-zno-nanowire-array-pbs-quantum-dots-film-heterostructure
#19
Zhi Zheng, Lin Gan, Jianbing Zhang, Fuwei Zhuge, Tianyou Zhai
ZnO nanostructure-based photodetectors have a wide applications in many aspects, however, the response range of which are mainly restricted in the UV region dictated by its bandgap. Herein, UV-vis-NIR sensitive ZnO photodetectors consisting of ZnO nanowires (NW) array/PbS quantum dots (QDs) heterostructures are fabricated through modified electrospining method and an exchanging process. Besides wider response region compared to pure ZnO NWs based photodetectors, the heterostructures based photodetectors have faster response and recovery speed in UV range...
March 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28331308/highly-effective-photothermal-chemotherapy-with-ph-responsive-polymer-coated-drug-loaded-melanin-like-nanoparticles
#20
Chengwei Zhang, Xiaozhi Zhao, Suhan Guo, Tingsheng Lin, Hongqian Guo
Dopamine is a neurotransmitter commonly used in clinical treatment. Polydopamine (PDA) has excellent histocompatibility and biosafety and can efficiently convert near-infrared reflection (NIR) to thermal energy. In this study, PDA was used as a promising carrier, and pH-responsive polymer-coated drug-loaded PDA nanoparticles (NPs; doxorubicin@ poly(allylamine)-citraconic anhydride [Dox@PAH-cit]/PDA NPs) were developed. As expected, the Dox@PAH-cit/PDA NPs exhibited excellent photothermal efficiency. In addition, at a low pH condition, the loaded Dox was released from the NPs due to the amide hydrolysis of PAH-cit...
2017: International Journal of Nanomedicine
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