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Hypoxia and metastasis

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https://www.readbyqxmd.com/read/28918350/expression-and-functional-characterization-of-the-bnip3-protein-in-renal-cell-carcinomas
#1
Stephan Macher-Goeppinger, Martina Keith, Gencay Hatiboglu, Markus Hohenfellner, Peter Schirmacher, Wilfried Roth, Katrin E Tagscherer
BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only protein that regulates apoptosis and autophagy. BNIP3 plays also an important role in hypoxia-induced cell response and is regulated by HIF1. Here, we studied a possible association of BNIP3 expression and the prognosis of patients with renal cell carcinomas (RCCs) and examined the functional relevance of BNIP3 in the regulation of cell survival and apoptosis of renal carcinoma cells. BNIP3 expression was determined by immunohistochemistry in RCC tumor tissue samples of 569 patients using a tissue microarray...
September 14, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28913935/induction-of-cancer-cell-stemness-by-depletion-of-macrohistone-h2a1-in-hepatocellular-carcinoma
#2
Oriana Lo Re, Caterina Fusilli, Francesca Rappa, Matthias Van Haele, Julien Douet, Jana Pindjakova, Sura Wanessa Rocha, Illar Pata, Barbora Valčíková, Stjepan Uldrijan, Raymond S Yeung, Christina Alves Peixoto, Tania Roskams, Marcus Buschbeck, Tommaso Mazza, Manlio Vinciguerra
Hepatocellular carcinomas (HCC) contain a sub-population of cancer stem cells (CSCs), which exhibit stem-cell like features and are responsible for tumor relapse, metastasis, and chemoresistance. The development of effective treatments for HCC will depend on a molecular-level understanding of the specific pathways driving CSC emergence and stemness. MacroH2A1 is a variant of the histone H2A and an epigenetic regulator of stem cell function, where it promotes differentiation and, conversely, acts as a barrier to somatic cell reprogramming...
September 15, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28912885/brusatol-mediated-inhibition-of-c-myc-increases-hif-1%C3%AE-degradation-and-causes-cell-death-in-colorectal-cancer-under-hypoxia
#3
Eun-Taex Oh, Chan Woo Kim, Ha Gyeong Kim, Jae-Seon Lee, Heon Joo Park
HIF-1 (hypoxia-inducible factor-1) regulates the expression of ~100 genes involved in angiogenesis, metastasis, tumor growth, chemoresistance and radioresistance, underscoring the growing interest in targeting HIF-1 for cancer control. In the present study, we investigated the molecular mechanisms underlying brusatol-induced HIF-1α degradation and cell death in colorectal cancer under hypoxia (0.5% O2). Under hypoxia, pretreatment of cancer cells with brusatol increased HIF-1α degradation and cancer cell death in a dose-dependent manner...
2017: Theranostics
https://www.readbyqxmd.com/read/28911825/paving-the-rho-in-cancer-metastasis-rho-gtpases-and-beyond
#4
REVIEW
Sepp Jansen, Reinoud Gosens, Thomas Wieland, Martina Schmidt
Malignant carcinomas are often characterized by metastasis, the movement of carcinoma cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells first must adopt a pro-migratory phenotype and move through the surrounding stroma towards a blood or lymphatic vessel. Currently, there are very limited possibilities to target these processes therapeutically. The family of Rho GTPases is an ubiquitously expressed division of GTP-binding proteins involved in the regulation of cytoskeletal dynamics and intracellular signaling...
September 11, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28911625/suppression-of-erk1-2-and-hypoxia-pathways-by-four-phyllanthus-species-inhibits-metastasis-of-human-breast-cancer-cells
#5
Sau H Lee, Indu B Jaganath, Nadia Atiya, Rishya Manikam, Shamala D Sekaran
Chemotherapies remain far from ideal due to drug resistance; therefore, novel chemotherapeutic agents with higher effectiveness are crucial. The extracts of four Phyllanthus species, namely Phyllanthus niruri, Phyllanthus urinaria, Phyllanthus watsonii, and Phyllanthus amarus, were shown to induce apoptosis and inhibit metastasis of breast carcinoma cells (MCF-7). The main objective of this study was to determine the pathways utilized by these four Phyllanthus species to exert anti-metastatic activities. A cancer 10-pathway reporter was used to investigate the pathways affected by the four Phyllanthus species...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28901751/sulfate-aerosols-promote-lung-cancer-metastasis-by-epigenetically-regulating-the-epithelial-to-mesenchymal-transition-emt
#6
Yang Yun, Rui Gao, Huifeng Yue, Lin Guo, Guangke Li, Nan Sang
Secondary inorganic aerosols (SIA), particularly sulfate aerosols, are central particulate matter (PM) constituents of severe haze formation in China and exert profound impacts on human health; however, our understanding of the mechanisms by which sulfate aerosols cause malignancy in lung carcinogenesis remains incomplete. Here, we show that exposure to secondary inorganic aerosols induced the invasion and migration of lung epithelial cells, and that (NH4)2SO4 exerted the most serious effects in vitro and promoted lung tumor metastasis in vivo...
September 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28901527/hypoxia-promotes-migration-invasion-and-glycolysis-in-head-and-neck-squamous-cell-carcinoma-via-an-hif-1%C3%AE-mtdh-loop
#7
Gangcai Zhu, Fusen Peng, Wei Gong, Li She, Ming Wei, Haolei Tan, Changhan Chen, Diekuo Zhang, Guo Li, Donghai Huang, Xin Zhang, Yong Liu
Hypoxia is a hallmark of progressive cancer. Hypoxic cancer cells trigger glycolysis in response to a decreased O2 supply to meet metabolic and bioenergetic demands. Meanwhile, these responses to hypoxia and alterations of the microenvironment promote cancer cell metastasis by increasing transcription of hypoxia-inducible factor (HIF)-regulated genes. However, the detailed mechanism by which hypoxia regulates cancer cell metastasis and glycolysis remains to be investigated. In the present study, we identified that metadherin (MTDH), a multifaceted oncogene, is involved in the regulation of head and neck squamous cell carcinoma (HNSCC) metastasis and invasion under hypoxic conditions...
September 7, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28901473/phd3-affects-gastric-cancer-progression-by-negatively-regulating-hif1a
#8
Ying-Jie Xia, Xiao-Ting Jiang, Shi-Bin Jiang, Xu-Jun He, Jun-Gang Luo, Zheng-Chuang Liu, Liang Wang, Hou-Quan Tao, Jian-Zhong Chen
Prolyl hydroxylase 3 (PHD3) is widely accepted as a tumor suppressor; however, the expression of PHD3 in various cancer types remains controversial. The present study aimed to investigate the association between PHD3 expression and the clinicopathological features of gastric cancer using reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry. The effects of PHD3 in gastric cancer cell lines were assessed using western blot analysis and transwell migration assays. The present results revealed that PHD3 expression was increased in adjacent non‑cancerous tissue compared with in gastric cancer tissue, and PHD3 overexpression was correlated with the presence of well‑differentiated cancer cells, early cancer stage classification and the absence of lymph node metastasis...
September 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28886531/long-non-coding-rna-hottip-promotes-hypoxia-induced-epithelial-mesenchymal-transition-of-malignant-glioma-by-regulating-the-mir-101-zeb1-axis
#9
Shanyi Zhang, Weiwei Wang, Guoxin Liu, Shule Xie, Qunxing Li, Yingru Li, Zhaoyu Lin
Hypoxia is a universal characteristic of solid tumor and involving cancer metastasis via epithelial-mesenchymal transition (EMT). Long non-coding RNAs (lncRNAs) are known to regulate carcinogenesis and metastasis of various cancers. The aim of this study was to identify the function role of lncRNAs in the hypoxia-induced EMT of malignant glioma. We used U87 and U251 cell lines were treated under hypoxia to induce EMT, then lncRNA microarray analyse was performed between U87-hypoxia and parental cell line. The relative expression of lncRNA and HIF-1α were detected by qRT-PCR between glioma tissues without metastasis and that with metastasis...
September 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28886304/the-roles-of-vasohibin-and-its-family-members-beyond-angiogenesis-modulators
#10
Hua Du, Jing Zhao, Ling Hai, Jing Wu, Hua Yi, Yonghong Shi
Vasohibin-1 is an intrinsic angiogenesis inhibitor, and is expressed in endothelial cells via induction by pro-angiogenesis factors. It is known to inhibit several processes of angiogenesis, with different mechanisms from extrinsic angiogenesis inhibitors. Vasohibin-2 is mainly expressed by mononuclear cells which have been mobilized from bone marrow. It not only promotes angiogenesis, but also modulates the releases of FGF-2 and VEGF, which are the two major inducers for vasohibin1. Hypoxic environment induces the expression of hypoxia-inducible Factor 1α with a result of VEGF release nearly in all tumor cell lines and tissues...
September 8, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28883755/effect-of-glucose-level-on-chemical-hypoxia-and-hydrogen-peroxide-induced-chemokine-expression-in-human-glioblastoma-cell-lines
#11
Yieun Jung, So-Hee Ahn, Sang Hui Park, Youn-Hee Choi
Glioblastoma multiforme (GBM) is the most common primary intracranial tumor in adults and has poor prognosis. The GBM-specific tumor microenvironment (TME) plays a crucial role in tumor progression, immune escape, local invasion, and metastasis of GBM. Here, we demonstrate that hypoxia, reactive oxygen species (ROS), and differential concentration of glucose influence the expression of cytokines and chemokines, such as IL-6, IL-8, and IP-10, in human glial cell lines. Treatment with cobalt chloride (CoCl2) and hydrogen peroxide (H2O2) significantly increased the expression levels of IL-6, IL-8, and IP-10 in a dose-dependent manner in CRT-MG and U251-MG astroglioma cells, but not in microglia cells...
September 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28878571/ribonucleic-acid-interference-knockdown-of-il-6-enhances-the-efficacy-of-cisplatin-in-laryngeal-cancer-stem-cells-by-down-regulating-the-il-6-stat3-hif1-pathway
#12
Qiang Fu, Pengruofeng Liu, Xiumei Sun, Shanshan Huang, Fengchan Han, Lili Zhang, Yannan Xu, Tingyan Liu
BACKGROUND: Cisplatin has been used in the treatment of many cancers, including laryngeal cancer; however, its efficacy can be reduced due to the development of drug resistance. This study aimed to investigate whether interleukin-6 (IL-6) knockdown may enhance the efficacy of cisplatin in laryngeal cancer stem cells (CSC) and the potential involvement of the signal transducer and activator of transcription 3 (STAT3) and hypoxia-inducible factor 1 (HIF1) in this effect. METHODS: The ALDH+ and CD44+ CSC in Hep2 human laryngeal squamous cancer cells were identified by the fluorescence-activated cell sorting technique...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28875379/tumor-vessel-disintegration-by-maximum-tolerable-pfkfb3-blockade
#13
Lena-Christin Conradi, Aleksandra Brajic, Anna Rita Cantelmo, Ann Bouché, Joanna Kalucka, Andreas Pircher, Ulrike Brüning, Laure-Anne Teuwen, Stefan Vinckier, Bart Ghesquière, Mieke Dewerchin, Peter Carmeliet
Blockade of the glycolytic activator PFKFB3 in cancer cells (using a maximum tolerable dose of 70 mg/kg of the PFKFB3 blocker 3PO) inhibits tumor growth in preclinical models and is currently being tested as a novel anticancer treatment in phase I clinical trials. However, a detailed preclinical analysis of the effects of such maximum tolerable dose of a PFKFB3 blocker on the tumor vasculature is lacking, even though tumor endothelial cells are hyper-glycolytic. We report here that a high dose of 3PO (70 mg/kg), which inhibits cancer cell proliferation and reduces primary tumor growth, causes tumor vessel disintegration, suppresses endothelial cell growth for protracted periods, (model-dependently) aggravates tumor hypoxia, and compromises vascular barrier integrity, thereby rendering tumor vessels more leaky and facilitating cancer cell intravasation and dissemination...
September 5, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28864720/overexpression-of-trpc5-promotes-tumor-metastasis-via-the-hif-1%C3%AE-twist-signaling-pathway-in-colon-cancer
#14
Zhen Chen, Yaodan Zhu, Yongfei Dong, Peng Zhang, Xiping Han, Jian Jin, Xin Ma
In cancer cells, the intracellular Ca(2+) ([Ca(2+)]i) homeostasis is altered, and this is involved in tumor initiation, progression, and metastasis. However, little is known about the underlying mechanisms. Here, we report that transient receptor potential channel 5 (TrpC5), a receptor-activated non-selective Ca(2+) channel, is correlated with tumor metastasis in colon cancer patients. Moreover, in colon cancer cells, overexpression TrpC5 caused a robust [Ca(2+)]i rise, decreased E-cadherin, and increased mesenchymal biomarker expression, then promoted cell migration, invasion, and proliferation...
September 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28854949/pulmonary-tumor-embolism-secondary-to-soft-tissue-and-bone-sarcomas-a-case-report-and-literature-review
#15
Nicholas Latchana, Vincent C Daniel, Robert W Gould, Raphael E Pollock
BACKGROUND: Tumor embolisms (TE) are an underappreciated source of pulmonary embolisms in sarcoma. Most evidence in the literature is limited to case reports and none have described the presence of TE secondary to myxofibrosarcoma. We report the first case of myxofibrosarcoma TE and perform a review of the literature for TE secondary to bone and soft tissue sarcomas (STS). CASE PRESENTATION: A 36-year-old female presented with debilitating pain of the right upper extremity secondary to a recurrent soft tissue sarcoma...
August 30, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28854900/vegfr2-regulates-endothelial-differentiation-of-colon-cancer-cells
#16
Zhiyong Liu, Lisha Qi, Yixian Li, Xiulan Zhao, Baocun Sun
BACKGROUND: Recent studies suggested that cancer stem-like cells contribute to tumor vasculogenesis by differentiating into endothelial cells. However, such process is governed by still undefined mechanism. METHODS: At varying differentiation levels, three representative colon cancer cells were cultured in endothelial-inducing conditioned medium: human colon cancer cells HCT116 (HCT116) (poorly differentiated), SW480 (moderately differentiated), and HT29 (well differentiated)...
August 30, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28846661/multimodality-imaging-in-tumor-angiogenesis-present-status-and-perspectives
#17
REVIEW
Artor Niccoli Asabella, Alessandra Di Palo, Corinna Altini, Cristina Ferrari, Giuseppe Rubini
Angiogenesis is a complex biological process that plays a central role in progression of tumor growth and metastasis. It led to a search for antiangiogenic molecules, and to design antiangiogenic strategies for cancer treatment. Noninvasive molecular imaging, such as positron emission tomography (PET) and single photon emission computed tomography (SPECT), could be useful for lesion detection, to select patients likely to respond to antiangiogenic therapies, to confirm successful targeting, and dose optimization...
August 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28841829/hypoxic-exosomes-facilitate-bladder-tumor-growth-and-development-through-transferring-long-non-coding-rna-uca1
#18
Mei Xue, Wei Chen, An Xiang, Ruiqi Wang, He Chen, Jingjing Pan, Huan Pang, Hongli An, Xiang Wang, Huilian Hou, Xu Li
BACKGROUND: To overcome the hostile hypoxic microenvironment of solid tumors, tumor cells secrete a large number of non-coding RNA-containing exosomes that facilitate tumor development and metastasis. However, the precise mechanisms of tumor cell-derived exosomes during hypoxia are unknown. Here, we aim to clarify whether hypoxia affects tumor growth and progression by transferring long non-coding RNA-urothelial cancer-associated 1 (lncRNA-UCA1) enriched exosomes secreted from bladder cancer cells...
August 25, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28832662/oxygen-dependent-regulation-of-tumor-growth-and-metastasis-in-human-breast-cancer-xenografts
#19
Kristine Yttersian Sletta, Maria K Tveitarås, Ning Lu, Agnete S T Engelsen, Rolf K Reed, Annette Garmann-Johnsen, Linda Stuhr
BACKGROUND: Tumor hypoxia is relevant for tumor growth, metabolism, resistance to chemotherapy and metastasis. We have previously shown that hyperoxia, using hyperbaric oxygen treatment (HBOT), attenuates tumor growth and shifts the phenotype from mesenchymal to epithelial (MET) in the DMBA-induced mammary tumor model. This study describes the effect of HBOT on tumor growth, angiogenesis, chemotherapy efficacy and metastasis in a triple negative MDA-MB-231 breast cancer model, and evaluates tumor growth using a triple positive BT-474 breast cancer model...
2017: PloS One
https://www.readbyqxmd.com/read/28819426/central-role-of-cemip-in-tumorigenesis-and-its-potential-as-therapeutic-target
#20
REVIEW
Li Li, Lin-Hai Yan, Shwetha Manoj, Ying Li, Lu Lu
CEMIP (KIAA1199) was identified as migratory indicator protein which had been crudely studied in the last decade. Firstly its mutation site was reported to cause hearing loss due to the folding change of protein structure, meanwhile the over-expression of CEMIP referred to dreadful invasion and uncontrolled proliferation of tumor with distant metastasis, dedifferentiation, and limited survival opportunity of patients. Especially, over-expressed CEMIP also protected malignant tumor from strict microenvironment in hypoxia, low glucose and cracked barrier, leading to enhanced adaptability of tumor by stimulating the Wnt, EGFR, FGFR pathway...
2017: Journal of Cancer
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