keyword
MENU ▼
Read by QxMD icon Read
search

Hypoxia and metastasis

keyword
https://www.readbyqxmd.com/read/27918549/a-hypoxia-responsive-traf6-atm-h2ax-signalling-axis-promotes-hif1%C3%AE-activation-tumorigenesis-and%C3%A2-metastasis
#1
Abdol-Hossein Rezaeian, Chien-Feng Li, Ching-Yuan Wu, Xian Zhang, Jorge Delacerda, M James You, Fei Han, Zhen Cai, Yun Seong Jeong, Guoxiang Jin, Liem Phan, Ping-Chieh Chou, Mong-Hong Lee, Mien-Chie Hung, Dos Sarbassov, Hui-Kuan Lin
The understanding of how hypoxia stabilizes and activates HIF1α in the nucleus with related oncogenic signals could revolutionize targeted therapy for cancers. Here, we find that histone H2AX displays oncogenic activity by serving as a crucial regulator of HIF1α signalling. H2AX interacts with HIF1α to prevent its degradation and nuclear export in order to allow successful VHL-independent HIF1α transcriptional activation. We show that mono-ubiquitylation and phosphorylation of H2AX, which are strictly mediated by hypoxia-induced E3 ligase activity of TRAF6 and ATM, critically regulate HIF1α-driven tumorigenesis...
December 5, 2016: Nature Cell Biology
https://www.readbyqxmd.com/read/27910777/gastric-adenocarcinoma-biomarker-expression-profiles-and-their-prognostic-value
#2
Serkan Senol, Abdullah Aydin, Duygu Kosemetin, Dilek Ece, Ibrahim Akalin, Hasan Abuoglu, Esra Akdeniz Duran, Dincer Aydin, Burcak Erkol
Expression levels of several molecules implicated in carcinogenesis were examined by immunohistochemical staining, and the prognostic significance of their expression levels in gastric adenocarcinoma (GA) was evaluated. A total of 115 GA and 20 control gastric tissue samples were evaluated by immunohistochemistry using 33 antibodies targeting molecules known to play a part in the development of various tumors. Overexpression of carbonic anhydrase IX (CAIX) and loss of AT-rich interactive domain-containing protein 1A (ARID1A), aldehyde dehydrogenase 1 (ALDH1), and CD44 expression in GA patients were significantly correlated with lymph node (LN) metastasis, advanced tumor stage, and poor prognosis...
2016: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/27900001/expression-of-glucose-transporter-1-is-correlated-with-hypoxia-inducible-factor-1%C3%AE-and-malignant-potential-in-pancreatic-neuroendocrine-tumors
#3
Minoru Fujino, Shinichi Aishima, Koji Shindo, Yasunori Oda, Katsuya Morimatsu, Kosuke Tsutsumi, Takao Otsuka, Masao Tanaka, Yoshinao Oda
The present study aimed to investigate the prognostic usefulness of the expression of glucose transporter type 1 (GLUT-1) and GLUT-2, hypoxia-inducible factor 1α (HIF-1α) and insulin-like growth factor II messenger RNA-binding protein 3 (IMP3) in pancreatic neuroendocrine tumors (pNETs). Immunohistochemical staining for GLUT-1, GLUT-2, HIF-1α and IMP3 was performed in 70 pNET specimens. The expression of GLUT-1 and HIF-1α was significantly higher in the World Health Organization grade 2 (G2), neuroendocrine carcinoma cases and mixed-type pNETs compared with the G1 cases...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895979/optical-redox-ratio-identifies-metastatic-potential-dependent-changes-in-breast-cancer-cell-metabolism
#4
Kinan Alhallak, Lisa G Rebello, Timothy J Muldoon, Kyle P Quinn, Narasimhan Rajaram
The development of prognostic indicators of breast cancer metastatic risk could reduce the number of patients receiving chemotherapy for tumors with low metastatic potential. Recent evidence points to a critical role for cell metabolism in driving breast cancer metastasis. Endogenous fluorescence intensity of nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) can provide a label-free method for assessing cell metabolism. We report the optical redox ratio of FAD/(FAD + NADH) of four isogenic triple-negative breast cancer cell lines with varying metastatic potential...
November 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27877208/selection-analysis-and-improvement-of-anti-angiogenesis-compounds-identified-by-an-anti-hif-1%C3%AE-screening-and-validation-system
#5
Chikezie Madu, Liyuan Li, Yi Lu
Cancer cells resort to activating hypoxia-inducible factor-1 (HIF-1) as one of several responses to hypoxic conditions. Overexpression of HIF-1, the transcriptional regulator for a group of malignant-pathway related genes including vascular endothelial growth factor (VEGF), is associated with increased tumor growth, vascularization, and metastasis. HIF-1 is composed of an inducible subunit, HIF-1α and a constitutively expressed subunit, HIF-1ß. HIF-1 activity is mainly dependent on the level of HIF-1α protein, the inducible and regulatory subunit of the HIF-1 heterodimer complex; thus, identification of novel anti-HIF-1α agents will lead to effective blockage of the HIF-1 (HIF-1α)-mediated "switch-on" function for those malignant-pathway related genes and suppression of the HIF-1α/VEGF-mediated signaling pathway that promotes cancer progression and metastasis...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27869227/hypoxia-induced-vasculogenic-mimicry-formation-in-human-colorectal-cancer-cells-involvement-of-hif-1a-claudin-4-and-e-cadherin-and-vimentin
#6
Wen Li, ShaoQi Zong, Qi Shi, HongJia Li, Jian Xu, Fenggang Hou
Vasculogenic mimicry (VM) plays an important role in colorectal cancer (CRC) metastasis, and both hypoxia and the epithelial-mesenchymal transition (EMT) are necessary for VM. In this study, HIF-1α expression was upregulated in the VM-positive CRC cell line HCT-116 and thereby affected the expression of the EMT-related markers Claudin-4, E-cadherin (E-cd) and Vimentin(VIM). SB431542 and U0126EtOH, which can inhibit of EMT were used to treat HCT-116 and HCT-8 in these experiments. Both of the inhibitors had significant effect on EMT markers and the formations of VM in CRC cells...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27867016/vasohibin-2-promotes-epithelial-mesenchymal-transition-in-human-breast-cancer-via-activation-of-transforming-growth-factor-%C3%AE-1-and-hypoxia-dependent-repression-of-gata-binding-factor-3
#7
Min Tu, Zhanjun Li, Xian Liu, Nan Lv, Chunhua Xi, Zipeng Lu, Jishu Wei, Guoxin Song, Jianmin Chen, Feng Guo, Kuirong Jiang, Shui Wang, Wentao Gao, Yi Miao
Vasohibin 2 (VASH2) is identified as an angiogenic factor, and has been implicated in tumor angiogenesis, proliferation and epithelial-mesenchymal transition (EMT). To investigate the EMT role of VASH2 in breast cancer, we overexpressed or knocked down expression of VASH2 in human breast cancer cell lines. We observed that VASH2 induced EMT in vitro and in vivo. The transforming growth factor β1 (TGFβ1) pathway was activated by VASH2, and expression of a dominant negative TGFβ type II receptor could block VASH2-mediated EMT...
November 17, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27862063/comparative-expression-analysis-of-hypoxia-inducible-factor-alpha-and-its-natural-occurring-antisense-in-breast-cancer-tissues-and-adjacent-noncancerous-tissues
#8
Behnoosh Tasharrofi, Mohammad Soudyab, Elahe Nikpayam, Mostafa Iranpour, Reza Mirfakhraie, Shaghayegh Sarrafzadeh, Lobat Geranpayeh, Eznollah Azargashb, Arezou Sayad, Soudeh Ghafouri-Fard
Hypoxia-inducible factors (HIFs) have been shown to be upregulated in tumor tissues and linked with tumor progression and metastasis in breast cancer. Among regulatory mechanisms for HIF expression is a natural occurring antisense named aHIF, which has been shown to be overexpressed in breast cancer and influence the level of the HIF-1α transcript. In the present study, we analyzed the expression of HIF-1α and aHIF in breast cancer tissues versus adjacent noncancer tissues (ANCTs) in relation with the clinical and biological behavior of the tumors...
November 12, 2016: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/27835695/reference-genes-for-addressing-gene-expression-of-bladder-cancer-cell-models-under-hypoxia-a-step-towards-transcriptomic-studies
#9
Luís Lima, Cristiana Gaiteiro, Andreia Peixoto, Janine Soares, Manuel Neves, Lúcio Lara Santos, José Alexandre Ferreira
Highly aggressive, rapidly growing tumors contain significant areas of hypoxia or anoxia as a consequence of inadequate and/or irregular blood supply. During oxygen deprivation, tumor cells withstand a panoply of adaptive responses, including a shift towards anaerobic metabolism and the reprogramming of the transcriptome. One of the major mediators of the transcriptional hypoxic response is the hypoxia-inducible factor 1 (HIF-1), whose stabilization under hypoxia acts as an oncogenic stimulus contributing to chemotherapy resistance, invasion and metastasis...
2016: PloS One
https://www.readbyqxmd.com/read/27834582/hypoxia-regulates-anxa1-expression-to-support-prostate-cancer-cell-invasion-and-aggressiveness
#10
Valentina Bizzarro, Raffaella Belvedere, Vincenzo Migliaro, Elena Romano, Luca Parente, Antonello Petrella
Annexin A1 (ANXA1) is a Ca(2+)-binding protein over-expressed in the invasive stages of prostate cancer (PCa) development; however, its role in this tumor metastatization is largely unknown. Moreover, hypoxic conditions in solid tumors have been related to poor prognosis in PCa patients. We have previously demonstrated that ANXA1 is implicated in the acquisition of chemo-resistant features in DU145 PCa cells conferring them a mesenchymal/metastatic phenotype. In this study, we have investigated the mechanisms by which ANXA1 regulates metastatic behavior in LNCaP, DU145 and PC3 cells exposed to hypoxia...
November 11, 2016: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27829135/macrophage-metabolism-shapes-angiogenesis-in-tumors
#11
Alberto Mantovani, Massimo Locati
In this issue, Wenes et al. (2016) show that REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells leads to an abnormal, leaky vascular network. Targeting REDD1 normalizes glycolysis in TAMs, stabilizes the vascular network, and inhibits metastasis.
November 8, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27823907/impact-of-hypoxia-inducible-factors-on-estrogen-receptor-expression-in-breast-cancer-cells
#12
Matthias Wolff, Friederike Katharina Kosyna, Jürgen Dunst, Wolfgang Jelkmann, Reinhard Depping
In women breast cancer is still the most commonly diagnosed cancer. This type of cancer is classified as a hormone-dependent tumor. Estrogen receptor (ER) expression and functional status contribute to breast cancer development and progression. Another important factor associated with cancer is hypoxia which is defined as the state of reduced oxygen availability in tissues. Intratumoral hypoxia results in the activation of the hypoxia inducible factors (HIFs). HIFs are heterodimeric transcription factors involved in the regulation of many cellular processes, such as angiogenesis, anaerobic metabolism, cell proliferation/survival, and promotion of metastasis...
November 5, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27815019/expression-of-netrin-1-by-hypoxia-contributes-to-the-invasion-and-migration-of-prostate-carcinoma-cells-by-regulating-yap-activity
#13
Haiwen Chen, Qi Chen, Qidong Luo
Hypoxia is a hallmark of solid tumor growth microenvironment and appropriates the major contributor for the failure and poor prognosis of clinical tumor treatment, including prostate cancer (PCa). Ectopic expression of netrin-1 is reportedly associated with the progression of several carcinomas. Here, we aimed to investigate the role of netrin-1 in hypoxic metastasis potential of prostate carcinoma. Here, hypoxia induced the up-regulation of netrin-1 mRNA and protein expression in prostate cancer cell lines PC3 and DU145...
November 1, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27814385/from-proteomic-analysis-to-potential-therapeutic-targets-functional-profile-of-two-lung-cancer-cell-lines-a549-and-sw900-widely-studied-in-pre-clinical-research
#14
Luís Korrodi-Gregório, Vanessa Soto-Cerrato, Rui Vitorino, Margarida Fardilha, Ricardo Pérez-Tomás
Lung cancer is a serious health problem and the leading cause of cancer death worldwide. The standard use of cell lines as in vitro pre-clinical models to study the molecular mechanisms that drive tumorigenesis and access drug sensitivity/effectiveness is of undisputable importance. Label-free mass spectrometry and bioinformatics were employed to study the proteomic profiles of two representative lung cancer cell lines and to unravel the specific biological processes. Adenocarcinoma A549 cells were enriched in proteins related to cellular respiration, ubiquitination, apoptosis and response to drug/hypoxia/oxidative stress...
2016: PloS One
https://www.readbyqxmd.com/read/27805252/expression-of-lpa2-is-associated-with-poor-prognosis-in-human-breast-cancer-and-regulates-hif-1%C3%AE-expression-and-breast-cancer-cell-growth
#15
Min Li, Dong Xiao, Jia Zhang, Hangying Qu, Ya Yang, Yan Yan, Xu Liu, Jizhao Wang, Lin Liu, Jiansheng Wang, Xiaoyi Duan
Breast cancer (BC) generally exhibits poor prognosis owing to its invasive and metastatic characteristics and is the leading cause of cancer-related deaths in women worldwide. Lysophosphatidic acid receptor 2 (LPA2) and hypoxia inducible factor-1α (HIF-1α) were found to be correlated with BC invasion and metastasis, respectively. However, the effect of LPA2 on BC in Chinese women has not yet been reported, nor have the overall survival and prognostic significance of LPA2 or its association with HIF-1α in BC...
October 26, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27799782/cancer-fundamentals-behind-ph-targeting-and-the-double-edged-approach
#16
Tomas Koltai
The highly regulated pH of cells and the less-regulated pH of the surrounding extracellular matrix (ECM) is the result of a delicate balance between metabolic processes and proton production, proton transportation, chemical buffering, and vascular removal of waste products. Malignant cells show a pronounced increase in metabolic processes where the 10- to 15-fold rise in glucose consumption is only the tip of the iceberg. Aerobic glycolysis (Warburg effect) is one of the hallmarks of cancer metabolism that implies excessive production of protons, which if stayed inside the cells would result in fatal intracellular acidosis (maintaining a strict acid-base balance is essential for the survival of eukaryotic cells)...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27799248/structure-and-function-of-a-prostate-cancer-dissemination-permissive-extracellular-matrix
#17
Marie-France Penet, Samata Kakkad, Arvind P Pathak, Balaji Krishnamachary, Yelena Mironchik, Venu Raman, Meiyappan Solaiyappan, Zaver M Bhujwalla
PURPOSE: The poor prognosis of metastatic prostate cancer continues to present a major challenge in prostate cancer treatment. The tumor extracellular matrix (ECM) plays an important role in facilitating metastasis. Here we investigated the structure and function of an ECM that facilitates prostate cancer metastasis by comparing orthotopic tumors that frequently metastasize, to poorly metastatic subcutaneous tumors. EXPERIMENTAL DESIGN: Both tumors were derived from a human prostate cancer PC3 cell line engineered to fluoresce under hypoxia...
October 31, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27791998/interrelation-of-blood-coagulation-and-hemorheology-in-cancer
#18
Irina Tikhomirova, Elena Petrochenko, Yulia Malysheva, Mihail Ryabov, Nikolay Kislov
Cancer progression is associated with activation of blood coagulation. Blood coagulation process, platelet hemostasis and hemorheological properties were evaluated in patients with solid tumors (n = 27) before and after surgery and in healthy control (n = 20). The main features of blood coagulation process in cancer patients were elevated intensity and shortened period of contact phase of coagulation and inhibitedcx fibrinolysis stage. Such prothrombotic state was fixed before surgery as well as in early postoperative period in spite of preventing thromboprophylactic treatment...
October 27, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27790387/direct-visualization-of-the-phenotype-of-hypoxic-tumor-cells-at-single-cell-resolution-in-vivo-using-a-new-hypoxia-probe
#19
Yarong Wang, Haoxuan Wang, Jiufeng Li, David Entenberg, Alice Xue, Weigang Wang, John Condeelis
Tumor hypoxia is linked to tumor progression, metastasis, and therapy resistance. However, the underlying mechanisms behind this linkage are not fully understood. Here we present a novel fluorescent mCherry hypoxia-responsive marker that can be used in real time imaging to specifically and sensitively identify hypoxic cells in vivo at single cell resolution. Tumors derived from triple negative tumor cells expressing the hypoxia marker reveal that the hypoxic tumor cells congregate near flowing blood vessels...
2016: IntraVital
https://www.readbyqxmd.com/read/27790386/validation-of-a-device-for-the-active-manipulation-of-the-tumor-microenvironment-during-intravital-imaging
#20
James K Williams, David Entenberg, Yarong Wang, Alvaro Avivar-Valderas, Michael Padgen, Ashley Clark, Julio A Aguirre-Ghiso, James Castracane, John S Condeelis
The tumor microenvironment is recognized as playing a significant role in the behavior of tumor cells and their progression to metastasis. However, tools to manipulate the tumor microenvironment directly, and image the consequences of this manipulation with single cell resolution in real time in vivo, are lacking. We describe here a method for the direct, local manipulation of microenvironmental parameters through the use of an implantable Induction Nano Intravital Device (iNANIVID) and simultaneous in vivo visualization of the results at single-cell resolution...
2016: IntraVital
keyword
keyword
93983
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"