Read by QxMD icon Read


Andrew J Loveridge, Timothy Kuiper, Roger H Parry, Lovemore Sibanda, Jane Hunt Hunt, Brent Stapelkamp, Lovelater Sebele, David W Macdonald
Reports of livestock depredation by large predators were systematically collected at three study sites in northwestern Zimbabwe from 2008-2013. We recorded 1,527 incidents (2,039 animals killed and 306 injured). Lions (Panthera leo) and spotted hyaenas (Crocuta crocuta) were mostly responsible, and cattle and donkeys most frequently attacked. Patterns of predation were variable among study sites. Nevertheless, some overall patterns were apparent. Predators selected livestock close to the size of their preferred wild prey, suggesting behaviours evolved to optimise foraging success may determine the domestic species primarily preyed upon...
2017: PeerJ
Luke E Sebel, Steven M Graves, C Savio Chan, D James Surmeier
Typical antipsychotic drugs are widely thought to alleviate the positive symptoms of schizophrenia by antagonizing dopamine D2 receptors expressed by striatal spiny projection neurons (SPNs). What is less clear is why antipsychotics have a therapeutic latency of weeks. Using a combination of physiological and anatomical approaches in ex vivo brain slices from transgenic mice, it was found that 2 weeks of haloperidol treatment induced both intrinsic and synaptic adaptations specifically within indirect pathway SPNs (iSPNs)...
March 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Henry Ndaimani, Paradzayi Tagwireyi, Lovelater Sebele, Hillary Madzikanda
In dry biomes, spatio-temporal variation in surface water resource stocks is pervasive, with unknown effects on the ranging behaviour of large predators. This study assessed the effect of spatial variation in surface water resources on the ranging behaviour of the African wild dog (Lycaon pictus). We analyzed data for 1992 (dry year with 20 water points) and 2000 (wet year with 30 water points) against presence-only data for five packs of L. pictus in a part of Hwange National Park and adjacent smallholder communal farming areas in western Zimbabwe...
2016: PloS One
Tim Fieblinger, Steven M Graves, Luke E Sebel, Cristina Alcacer, Joshua L Plotkin, Tracy S Gertler, C Savio Chan, Myriam Heiman, Paul Greengard, M Angela Cenci, D James Surmeier
The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of striatal direct pathway spiny projection neurons (dSPNs) and indirect pathway spiny projection neurons (iSPNs) is disrupted, leading to aberrant action selection. However, it is unclear whether countervailing mechanisms are engaged in these states. Here we report that iSPN intrinsic excitability and excitatory corticostriatal synaptic connectivity were lower in PD models than normal; L-DOPA treatment restored these properties...
October 31, 2014: Nature Communications
Joshua L Plotkin, Weixing Shen, Igor Rafalovich, Luke E Sebel, Michelle Day, C Savio Chan, D James Surmeier
The induction of corticostriatal long-term depression (LTD) in striatal spiny projection neurons (SPNs) requires coactivation of group I metabotropic glutamate receptors (mGluRs) and L-type Ca(2+) channels. This combination leads to the postsynaptic production of endocannabinoids that act presynaptically to reduce glutamate release. Although the necessity of coactivation is agreed upon, why it is necessary in physiologically meaningful settings is not. The studies described here attempt to answer this question by using two-photon laser scanning microscopy and patch-clamp electrophysiology to interrogate the dendritic synapses of SPNs in ex vivo brain slices from transgenic mice...
November 2013: Journal of Neurophysiology
C Savio Chan, Jayms D Peterson, Tracy S Gertler, Kelly E Glajch, Ruth E Quintana, Qiaoling Cui, Luke E Sebel, Joshua L Plotkin, Weixing Shen, Myriam Heiman, Nathaniel Heintz, Paul Greengard, D James Surmeier
Mice carrying bacterial artificial chromosome (BAC) transgenes have become important tools for neuroscientists, providing a powerful means of dissecting complex neural circuits in the brain. Recently, it was reported that one popular line of these mice--mice possessing a BAC transgene with a D(2) dopamine receptor (Drd2) promoter construct coupled to an enhanced green fluorescent protein (eGFP) reporter--had abnormal striatal gene expression, physiology, and motor behavior. Unlike most of the work using BAC mice, this interesting study relied upon mice backcrossed on the outbred Swiss Webster (SW) strain that were homozygous for the Drd2-eGFP BAC transgene...
July 4, 2012: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
V Jegatheesan, L Shu, J Virkutyte, Chia-Yuan Chang
No abstract text is available yet for this article.
May 2011: Bioresource Technology
Matthew A Klopman, Peter S Sebel
PURPOSE OF REVIEW: In the current era of limited resources, organizations are evaluating the cost-effectiveness of their care. To analyze the cost-effectiveness of a physiologic monitor, one must first determine what negative outcome will be reduced or what positive outcome will be promoted. For example, if one was studying the cost-effectiveness of the pulse oximeter, it would be important to state whether the endpoint is prevention of hypoxic events or prevention of myocardial infarction...
April 2011: Current Opinion in Anaesthesiology
Peter S Sebel
No abstract text is available yet for this article.
September 2010: Anesthesia and Analgesia
Gopikrishna Deshpande, Chantal Kerssens, Peter Simon Sebel, Xiaoping Hu
Recently we introduced a robust measure, integrated local correlation (ILC), of local connectivity in the brain using fMRI data which reflects the temporal correlation of brain activity in every voxel neighborhood. The current work studies ILC in fMRI data obtained in the absence and presence of sevoflurane anesthesia (0%, 2%, and 1% end-tidal concentration, respectively) administered to healthy volunteers. ILC was determined specifically in regions of the default mode network (DMN) to address local changes in each state...
March 8, 2010: Brain Research
Chantal Kerssens, Julie R Gaither, Peter S Sebel
BACKGROUND: Memory function under anesthesia is undesired but may arise from light hypnosis as well as stress-enhanced learning during surgery. The bispectral index (BIS, Aspect Medical Systems, Norwood, MA) is a monitor of hypnotic state that can help to avoid light hypnosis (i.e., BIS above 60). This study tested the hypothesis that BIS-guided anesthesia maintaining BIS 50-60 reduces the likelihood of memory function under anesthesia. METHODS: After obtaining informed consent, 128 patients scheduled for joint replacement surgery under general anesthesia with sevoflurane were randomly assigned to BIS-guided anesthesia, titrating drugs to BIS 50-60 (BIS group), or a standard practice group in which BIS was recorded but did not guide drug administration...
September 2009: Anesthesiology
Peter S Sebel
No abstract text is available yet for this article.
May 2009: Anesthesia and Analgesia
Mohamed M Ghoneim, Robert I Block, Mary Haffarnan, Maya J Mathews
BACKGROUND: Awareness during anesthesia is uncommon. The number of cases that are found in one single study are insufficient to identify and estimate the risks, causal factors and sequelae. One method of studying a large number of cases is to analyze reports of cases of awareness that have been published in scientific journals. METHODS: We conducted an electronic search of the literature in the National Library of Medicine's PubMed database for case reports on "Awareness" and "Anesthesia" for the time period between 1950 through August, 2005...
February 2009: Anesthesia and Analgesia
Peter S Sebel
No abstract text is available yet for this article.
February 2009: Anesthesia and Analgesia
P S Sebel, N P de Bruijn, W K Neville
Median nerve somatosensory evoked potentials (SEP) were monitored in ten patients undergoing cardiac surgery with hypothermic cardiopulmonary bypass (CPB). Anesthesia was induced and maintained with sufentanil, oxygen, and pancuronium. Esophageal, nasopharyngeal, rectal, and blood temperatures were continuously monitored. SEPs were recorded before induction of anesthesia, after induction, and during cooling and rewarming on CPB. There was a strong negative correlation between SEP latencies and temperature (except rectal) (r = -...
June 1988: Journal of Cardiothoracic Anesthesia
D Green, P S Sebel
No abstract text is available yet for this article.
November 2006: European Journal of Anaesthesiology
G H Lubke, P S Sebel
Awareness during surgery and memory for perioperative events may have substantial psychological consequences for the patient. The risk of awareness during trauma surgery is higher than during most elective procedures due to the fact that administration of adequate concentrations of anaesthetics is not always feasible. As a consequence, the risk of memory formation might be increased. The present review discusses different forms of memory, and the possibilities and limitations of awareness and memory prevention...
April 2000: Current Opinion in Anaesthesiology
Luke E Sebel, James E Richardson, Sunil P Singh, Shannon V Bell, Andrew Jenkins
BACKGROUND: Previous studies have shown that propofol and sevoflurane enhance the function of gamma-aminobutyric acid type A (GABAA) receptors. However, it is not known whether these two drugs modulate the same molecular pathways. In addition, little is known about receptor function in the presence of both propofol and sevoflurane. The aim of this study was to better understand the interactions of propofol and sevoflurane with the GABAA receptor. METHODS: Wild-type alpha1, beta(2), gamma(2s) GABA(A) receptor subunit complementary DNAs were transfected into human embryonic kidney cells grown on glass coverslips using a calcium phosphate transfection method...
June 2006: Anesthesiology
Robert S Harris, Olga Lazar, Jay W Johansen, Peter S Sebel
BACKGROUND: Loss of consciousness (LOC) and immobility to surgical incision seem to be mediated at different levels of the central nervous system. Pharmacologic studies of hypnotic agents have previously focused on combinations of either volatile or intravenous anesthetics. This study examined the combination of inhaled sevoflurane and intravenous propofol at these two clinically relevant anesthetic end points. METHODS: Thirty-six elective surgical patients were initially enrolled...
June 2006: Anesthesiology
Chantal Kerssens, Peter S Sebel
No abstract text is available yet for this article.
February 2006: Anesthesia and Analgesia
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"