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Pediatric Thrombosis

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https://www.readbyqxmd.com/read/27905682/a-survey-of-pediatric-hematology-oncology-specialists-regarding-management-of-central-line-associated-venous-thrombosis
#1
Char M Witmer, Emily Sauck, Leslie J Raffini
Central venous catheters (CVCs) account for the largest proportion of thrombotic events in pediatric patients. Questions remain regarding adequate treatment and prevention methods. We surveyed pediatric hematology/oncology specialists, using hypothetical cases to assess management strategies for acute CVC thrombosis and secondary prevention. Survey respondents varied in the use of the thrombophilia evaluation (33.3%, 41/123) and duration of treatment (6 weeks: 54.1%, 66/122). Secondary CVC prophylaxis was utilized by 36...
December 1, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27902676/dural-sinus-cerebral-venous-thrombosis-in-a-pediatric-trauma-patient-a-rare-complication-after-closed-head-injury
#2
Jonathan Wilcher, Michelle Pannell
OBJECTIVE: Closed head injury rarely predisposes patients, particularly children, to the development of dural sinus thrombosis. In addition, most cases of sinus thrombosis are subacute in nature. The following is a case report of a precipitous course of dural sinus thrombosis after closed head injury in a pediatric trauma patient. DESCRIPTION: A 14-year-old African American girl presented to the emergency department as a trauma activation. She was an unrestrained rear-seat passenger involved in a motor vehicle collision during which she was ejected...
December 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27898631/traumatic-femoral-artery-thrombosis-diagnosed-by-point-of-care-ultrasonography-in-the-pediatric-emergency-department
#3
Sarah D Jones, Jason Fischer, Charisse Kwan, Mark Tessaro
Femoral artery injuries are a rare complication of blunt trauma in children that require expeditious diagnosis and treatment to prevent permanent limb dysfunction. Point-of-care ultrasonography of femoral vessels is a well-established emergency physician technique for ruling out deep vein thrombosis and guiding femoral vessel catheterization. We present the first report of a pediatric emergency physician diagnosing a traumatic femoral artery thrombus using point-of-care ultrasonography.
December 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27884452/factors-associated-with-thrombotic-complications-in-pediatric-patients-with-vascular-malformations
#4
Pablo Sepúlveda, Alejandro Zavala, Pamela Zúñiga
BACKGROUND AND OBJECTIVES: Thrombosis is an uncommon disorder in children. Patients with slowflow vascular malformations have higher risk of developing localized intravascular coagulation, which is closely related to the presence of thrombotic events. These episodes cause pain, can be recurrent and determine a clear deterioration in the quality of life. Moreover, serious complications such as pulmonary thromboembolism and eventually death have been described. The aim of the present study is to identify clinical and laboratory risk factors associated with thrombotic events in pediatric patients with vascular malformations...
November 6, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27880991/vascular-complications-in-living-donor-liver-transplantation-at-a-high-volume-centre-evolving-protocols-and-trends-observed-over-10-years
#5
A R Shiraz, M A Nayeem, S Agarwal, N Goyal, S Gupta
Vascular complications continue to have devastating effect; although their nature, incidence and outcome might have actually changed with increasing experience and proficiency in high volume centers. Aim was to analyze the trends observed in vascular complications with changing protocols in adult and pediatric- living donor liver transplantation (A-LDLT and P-LDLT) over 10 years in two time frames in terms of nature, incidence and outcome. It is a retrospective analysis of 391 (Group I= Jan. 2006- Dec.2010) and 741 (Group II= Jan...
November 23, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27862929/effects-of-recipient-size-and-allograft-type-on-pediatric-liver-transplantation-for-biliary-atresia
#6
Sophoclis P Alexopoulos, Victor Nekrasov, Shu Cao, Susan Groshen, Navpreet Kaur, Yuri S Genyk, Lea Matsuoka
RATIONALE: The majority of pediatric patients with end stage liver disease receive a transplant with a whole liver allograft. However, smaller recipients with biliary atresia may have improved outcomes with deceased donor partial liver or living donor allografts. This study compares the national outcomes for liver transplantation in biliary atresia, with attention to the interaction between liver allograft type and recipient size. RESULTS: From 1/2/2002 to 12/30/2014, 2123 pediatric patients underwent a primary liver transplant for biliary atresia...
November 10, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27861430/the-use-of-recombinant-antithrombin-iii-in-pediatric-and-neonatal-ecmo-patients
#7
Deanna R Todd Tzanetos, John Myers, Terri Wells, Dan Stewart, Jeffrey J Fanning, Janice E Sullivan
A retrospective review of 77 pediatric and neonatal ECMO patients who received recombinant antithrombin III (ATIII) for ATIII activity >80% was conducted.Anticoagulation management was per institutional protocol. An ATIII activity >80% was targeted. Diagnosis, reason for ECMO cannulation, blood product usage, heparin dosing, ATIII activity and doses, thrombotic and bleeding complications, hours on ECMO, and mortality were recorded. We calculated patient-level summary statistics and assessed differences between groups using χ2 tests (categorical variables) and Wilcoxon rank sum tests (continuous variables)...
November 15, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27861210/symptomatic-venous-thromboembolism-after-adolescent-knee-arthroscopy
#8
Robert F Murphy, Benton Heyworth, Dennis Kramer, Manahil Naqvi, Patricia E Miller, Yi-Meng Yen, Mininder S Kocher, Benjamin J Shore
BACKGROUND: The frequency of knee arthroscopy procedures is increasing in pediatric and adolescent patients. In general, complications after these procedures in adolescents are uncommon. The purposes of this study are to report the incidence of venous thromboembolism (VTE) in adolescent patients after knee arthroscopy procedures, as well identify risk factors in this patient population. METHODS: Medical records were reviewed in all pediatric and adolescent patients (≤19 y) who underwent an arthroscopic knee procedure from 2010 to 2014 and were diagnosed with a symptomatic VTE in the postoperative period...
November 17, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27850441/803-critical-care-utilization-and-outcomes-in-pediatric-cerebral-sinovenous-thrombosis
#9
Theresa Graif, Cydni Williams
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850154/514-contemporary-epidemiology-of-catheter-related-thrombosis-in-the-pediatric-cardiac-icu
#10
Lee Murphy, Christopher Mastropietro
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27820879/heparin-for-the-treatment-of-thrombosis-in-neonates
#11
REVIEW
Olga Romantsik, Matteo Bruschettini, Simona Zappettini, Luca Antonio Ramenghi, Maria Grazia Calevo
BACKGROUND: Among pediatric patients, newborns are at highest risk of developing thromboembolism. Neonatal thromboembolic (TE) events may consist of both venous and arterial thromboses and often iatrogenic complications (eg, central catheterization). Treatment guidelines for pediatric patients with TE events most often are extrapolated from the literature regarding adults. Options for the management of neonatal TE events include expectant management; nitroglycerin ointment; thrombolytic therapy or anticoagulant therapy, or a combination of the two; and surgery...
November 7, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27797270/diagnosis-and-management-of-factor-v-leiden
#12
Elena Campello, Luca Spiezia, Paolo Simioni
The discovery of the factor V Leiden (FVL) missense mutation (Arg506Gln) causing factor V resistance to the anticoagulant action of activated protein C was a landmark that allowed a better understanding of the basis of inherited thrombotic risk. FVL mutation is currently the most common known hereditary defect predisposing to venous thrombosis. Areas covered: Novel data-driven FVL diagnosis and therapeutic approaches in the management of FVL carriers in various clinical settings. Brief conclusions on topics of direct clinical relevance including currently available indications for primary and secondary prophylaxis, the management of female, pediatric carriers and asymptomatic relatives...
December 2016: Expert Review of Hematology
https://www.readbyqxmd.com/read/27796038/management-of-acute-complicated-mastoiditis-at-an-urban-tertiary-care-pediatric-hospital
#13
Saied Ghadersohi, Nancy M Young, Virginia Smith-Bronstein, Stephen Hoff, Kathleen R Billings
OBJECTIVES/HYPOTHESIS: To describe the presentation and management of acute complicated mastoiditis in children. STUDY DESIGN: Retrospective case series. METHODS: An analysis of pediatric patients with acute complicated mastoiditis treated at an urban, tertiary care children's hospital from 2007 to 2014 was performed. RESULTS: Forty-eight patients presented with a total of 67 complications of acute mastoiditis. Mean age at presentation was 4...
October 31, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27779446/a-comparison-of-extremity-thrombosis-rates-in-adolescent-and-young-adult-versus-younger-pediatric-oncology-patients-at-a-children-s-hospital
#14
James D Cooper, Aimee G Costello, Peter H Shaw
PURPOSE: To examine whether the rates of thrombosis in children (≤14 years of age) and adolescent/young adult (AYA) patients (15-22 years of age) with cancer is different. METHODS: We retrospectively studied the rates of thrombosis in children and AYA patients at the Children's Hospital of Pittsburgh during the years 2002-2010, using the tumor registry database. This list was then divided into two groups based on age at diagnosis. A review of ICD-9 codes from hospital billing records was then performed to identify patients who carried diagnoses of cancer (140...
October 25, 2016: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/27749807/presentation-of-acute-childhood-stroke-in-a-tertiary-pediatric-emergency-department
#15
Adriana Yock-Corrales, Flory Varela-Bulgarelli, Cary Barboza, Alfonso Gutierrez-Mata, Mark T Mackay, Franz Babl
OBJECTIVES: The aim was to describe clinical presentation, management, and outcomes of stroke in a tertiary emergency department (ED) of a developing country. METHODOLOGY: Retrospective case series of patients aged 1 month to 18 years presenting to an ED with radiological confirmed acute stroke during a 7-year period were studied. RESULTS: Ninety-five patients were identified. Twenty-five patients were excluded because of incomplete records (8) or not presenting via ED (17)...
October 4, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27743967/-idiopathic-intracranial-hypertension-experience-over-25-years-and-a-management-protocol
#16
Lorena Monge Galindo, Ruth Fernando Martínez, Cristina Fuertes Rodrigo, David Fustero de Miguel, Victoria Pueyo Royo, Juan Pablo García Iñiguez, Javier López-Pisón, José Luis Peña-Segura
INTRODUCTION: We present our experience on idiopathic intracranial hypertension (IIH), before and after the introduction of a specific diagnosis and management protocol. METHOD: A descriptive retrospective study was conducted on patients with IIH over a 25year period (1990-2015), comparing the last 7years (after introduction of the protocol) with the previous 18years. RESULTS: Among the 18,865 patients evaluated, there were 54 cases of IIH (29 infants and 25 children)...
October 13, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27731914/magnetic-resonance-imaging-of-ischemic-injury-produced-by-varying-severities-of-photothrombosis-differs-in-neonatal-and-adult-brain
#17
Ursula I Tuor, Min Qiao, Manasi Sule, Melissa Morgunov, Tadeusz Foniok
Stroke is a major cause of disability in adults and children. Recently, we have developed an adult rat model of minor stroke containing a peri-infarct region with a modest T2 increase and mild ischemic damage. We hypothesized that a neonatal minor stroke with mild peri-ischemic changes could also be produced, but with potential ontogenic differences. Using our minor photothrombosis method, we produced a range of severities of ischemic lesions (mini, minor, moderate and severe) within magnetic resonance imaging (MRI) slices of adult and neonatal rats...
October 12, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27722126/venous-thromboembolism-in-pediatric-patients-a-single-institution-experience-in-korea
#18
Hyoung Soo Choi, Chang Won Choi, Heon Min Kim, Hye Won Park
BACKGROUND: While venous thromboembolism (VTE) is uncommon, its incidence is increasing in children. We aimed to evaluate the incidence, risk factors, treatment, and outcome of pediatric VTE cases at a single tertiary hospital in Korea. METHODS: We retrospectively analyzed the records of consecutive pediatric VTE patients admitted to the Seoul National University Bundang Hospital between April 2003 and March 2016. RESULTS: Among 70,462 hospitalizations, 25 pediatric VTE cases were identified (3...
September 2016: Blood Research
https://www.readbyqxmd.com/read/27709837/development-of-captsure-%C3%A2-a-new-index-for-the-assessment-of-pediatric-postthrombotic-syndrome
#19
M L Avila, L R Brandão, S Williams, M I Montoya, J Stinson, A Kiss, B M Feldman
BACKGROUND: Postthrombotic syndrome (PTS) is a complication of deep vein thrombosis defined by the presence of characteristic signs and symptoms. We developed a discriminative and evaluative index for the assessment of upper and lower extremity (UE/LE) pediatric PTS. METHODS: The items to be included in the index were voted for by 26 pediatric thrombosis experts invited to participate in a Delphi survey. Subsequent item weighting was based on item importance elicited using multi-criteria decision analysis (MCDA); 122 health care providers and patients/parents participated in item weighting...
October 6, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27693278/-pediatric-kidney-transplantation
#20
L Badet, X Matillon, R Codas, M-O Timsit, R Thuret, F Kleinclauss, D Demede
AIMS: To describe indications, surgical aspects, results and outcomes of kidney transplantation in children. MATERIAL AND METHODS: An exhaustive systematic review of the scientific literature was performed in the Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) using different associations of the following keywords (MESH): "kidney transplantation", "pediatric", "children", "outcomes". Publications obtained were selected based on methodology, language, date of publication (last 10 years) and relevance...
September 29, 2016: Progrès en Urologie
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