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Rat achilles tendon

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https://www.readbyqxmd.com/read/28165813/piperine-ameliorates-collagenase-induced-achilles-tendon-injury-in-the-rat
#1
Fengyan Gong, Lifeng Cui, Xiaona Zhang, Xiangbo Zhan, Xu Gong, Yan Wen
Tendinopathy is a common clinical pathology found in athletes and workers with mixed treatment results. Piperine, a major alkaloid found in the black and long pepper, has been demonstrated to have variety of pharmacological properties such as analgesic and anti-inflammatory effects. The present study was designed to investigate the effects of piperine on collagenase-induced Achilles tendon injury. Rats were intratendineously injected with collagenase in the right Achilles tendon, followed by intragastrical administration of piperine (100 mg/kg)...
February 6, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28122008/compromised-neurotrophic-and-angiogenic-regenerative-capability-during-tendon-healing-in-a-rat-model-of-type-ii-diabetes
#2
Aisha S Ahmed, Jian Li, Alim M D Abdul, Mahmood Ahmed, Claes-Göran Östenson, Paul T Salo, Carolyn Hewitt, David A Hart, Paul W Ackermann
Metabolic diseases such as diabetes mellitus type-II (DM-II) may increase the risk of suffering painful connective tissue disorders and tendon ruptures. The pathomechanisms, however, by which diabetes adversely affects connective tissue matrix metabolism and regeneration, still need better definition. Our aim was to study the effect of DM-II on expressional changes of neuro- and angiotrophic mediators and receptors in intact and healing Achilles tendon. The right Achilles tendon was transected in 5 male DM-II Goto-Kakizaki (GK) and 4 age-matched Wistar control rats...
2017: PloS One
https://www.readbyqxmd.com/read/28095484/experimental-diabetes-alters-the-morphology-and-nano-structure-of-the-achilles-tendon
#3
Rodrigo Ribeiro de Oliveira, Rômulo Medina de Mattos, Luciana Magalhães Rebelo, Fernanda Guimarães Meireles Ferreira, Fernanda Tovar-Moll, Luiz Eurico Nasciutti, Gerly Anne de Castro Brito
Although of several studies that associate chronic hyperglycemia with tendinopathy, the connection between morphometric changes as witnessed by magnetic resonance (MR) images, nanostructural changes, and inflammatory markers have not yet been fully established. Therefore, the present study has as a hypothesis that the Achilles tendons of rats with diabetes mellitus (DM) exhibit structural changes. The animals were randomly divided into two experimental groups: Control Group (n = 06) injected with a vehicle (sodium citrate buffer solution) and Diabetic Group (n = 06) consisting of rats submitted to intraperitoneal administration of streptozotocin...
2017: PloS One
https://www.readbyqxmd.com/read/27927626/the-impact-of-tgf-%C3%AE-inhibition-during-acute-exercise-on-achilles-tendon-extracellular-matrix
#4
Ross M Potter, Richard T Huynh, Brent D Volper, Kathryn A Arthur, Andrew C D'Lugos, Mikkel A Sørensen, S Peter Magnusson, Jared M Dickinson, Taben M Hale, Chad C Carroll
The purpose of this study was to evaluate the role of TGF-β1 in regulating tendon extracellular matrix (ECM) after acute exercise. Wistar rats exercised (n=15) on a treadmill for four consecutive days (60 min/day) or maintained normal cage activity. After each exercise bout, the peritendinous space of each Achilles tendon was injected with a TGF-β1 receptor inhibitor or sham. Independent of group, tendons injected with inhibitor exhibited ~50% lower Smad 3 (Ser423/425) (p<0.05) and 2.5-fold greater ERK1/2 phosphorylation (p<0...
December 7, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27871421/mesenchymal-stem-cell-bearing-sutures-for-tendon-repair-and-healing-in-the-foot-and-ankle
#5
REVIEW
Eric W Tan, Lew C Schon
Improving the quality and strength of soft tissue repairs remains an important area of orthopedic research and innovation. The need for immobilization and early motion is an important balance essential for the successful treatment of tendon repair and reconstruction. Mesenchymal stem cell (MSC)-bearing sutures represent an emerging biological augmentation to traditional suture repair. Two previous large studies using stem cell sutures in rat Achilles tendon models have demonstrated early increased biomechanical strength and significantly increased ultimate failure strength...
December 2016: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/27855526/morphometric-properties-and-innervation-of-muscle-compartments-in-rat-medial-gastrocnemius
#6
Malwina Taborowska, Dorota Bukowska, Hanna Drzymała-Celichowska, Barbara Mierzejewska-Krzyżowska, Jan Celichowski
The rat medial gastrocnemius (MG) muscle is composed of the proximal and distal compartments. In this study, morphometric properties of the compartments and their muscle fibres at five levels of the muscle length and the innervation pattern of these compartments from lumbar segments were investigated. The size and number of muscle fibres in the compartments were different. The proximal compartment at the largest cross section (25% of the muscle length) had 34% smaller cross-sectional area but contained a slightly higher number of muscle fibres (max...
September 2016: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/27799714/effects-of-skin-stretching-without-joint-movement-on-skin-extensibility-of-rats
#7
Atsushi Tasaka, Takeya Ono, Hideki Ishikura, Kazuki Aihara, Yuta Sato, Tomohiro Matsumoto, Takeshi Morifuji, Sadaaki Oki
[Purpose] This study examined the possibility of maintaining skin extensibility by stretching the skin involved in disuse joint contracture. [Subjects and Methods] The study was carried out using 18 male Wistar rats. The rats were randomly allocated to three groups. The control group received no intervention for the right ankle joint, the fixation group received one-week's fixation of the right ankle joint in maximum plantar-flexion with a cast, and the stretching group received continuous stretching of the skin over the Achilles tendon for 30 min once daily for one week with the cast removed during the skin stretching, but the joint was not moved...
September 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27763655/periodontal-ligament-cells-as-alternative-source-for-cell-based-therapy-of-tendon-injuries-in-vivo-study-of-full-size-achilles-tendon-defect-in-a-rat-model
#8
C-F Hsieh, P Alberton, E Loffredo-Verde, E Volkmer, M Pietschmann, P E Müller, M Schieker, D Docheva
Tendon's natural healing potential is extremely low and inefficient, with significant dysfunction and disability due to hypocellularity and hypovascularity of tendon tissues. The application of stem cells can aid in significantly enhanced repair of tendon rupture; therefore, the main aim of this study is to assess the potential of using periodontal ligament cells (PDL), usually obtained from patients undergoing orthodontic treatment, as a novel cell source for cell-based therapy for tendon injuries in a clinically relevant rat full-size Achilles tendon defect...
October 20, 2016: European Cells & Materials
https://www.readbyqxmd.com/read/27742920/strenuous-treadmill-running-induces-a-chondrocyte-phenotype-in-rat-achilles-tendons
#9
Shao-Yong Xu, Shu-Fen Li, Guo-Xin Ni
BACKGROUND Although tendinopathy is common, its underlying pathogenesis is poorly understood. This study aimed to investigate the possible pathogenesis of tendinopathy. MATERIAL AND METHODS In this study, a total of 24 rats were randomly and evenly divided into a control (CON) group and a strenuous treadmill running (STR) group. Animals in the STR group were subjected to a 12-week treadmill running protocol. Subsequently, all Achilles tendons were harvested to perform histological observation or biochemical analyses...
October 15, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27692307/topical-fish-oil-application-coupling-with-therapeutic-ultrasound-improves-tendon-healing
#10
Karly O W Chan, Henry H Y Tong, Gabriel Y F Ng
Fish oil has been shown to promote collagen synthesis, and hence, connective tissue healing. Therapeutic ultrasound is commonly used to treat soft tissue injuries. This study aimed to investigate the therapeutic effect of topical fish oil on the management of Achilles tendon rupture, comparing normal therapeutic ultrasound with a combination of ultrasound and fish oil. Eighty-five Sprague-Dawley rats underwent surgical hemitenotomy of the right medial Achilles tendon. The rats received daily treatment of either topical placebo ointment (control group [CON]), topical fish oil (FO), therapeutic ultrasound (US) or ultrasound with fish oil as the coupling medium (FU)...
December 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27684081/effects-of-tumor-necrosis-factor-inhibitor-on-stress-shielded-tendons
#11
Kang Chen, Ping Li, Huakun Zhao, Xiaoyan Yan, Yanhong Ma
Mechanical stress plays an important role in preserving the integrity of bone and ligament. Stress shielding reduces mechanical load on bone or tendons, resulting in tissue degradation. Previous studies showed that deterioration of the tendon structure during stress shielding is associated with elevated expression of tumor necrosis factor (TNF)-α. This study examined the therapeutic potential of the TNF inhibitor etanercept in preventing morphologic deterioration of the Achilles tendon after stress shielding...
September 29, 2016: Orthopedics
https://www.readbyqxmd.com/read/27677200/phenytoin-accelerates-tendon-healing-in-a-rat-model-of-achilles-tendon-rupture
#12
B Hajipour, A M Navali, S Ali Mohammad, G Mousavi, M Gahvechi Akbari, T Maleki Miyandoab, L Roshangar, B Mohammadi Saleh, T Asvadi Kermani, F Moutab Laleh, M Ghabili
INTRODUCTION: Tendons are vulnerable to various types of acute or chronic injures. Different methods have been investigated to achieve better healing. Phenytoin is a drug which could stimulate fibroblasts to produce collagen. This experimental study was performed to assess the effect of phenytoin on tendon healing in a rat model of tendon rupture. METHODS: Thirty healthy rats were divided into 3 groups, 1) Sham group; 2) Tendon rupture; 3) Tendon rupture+phenytoin (100 mg/kg intraperitoneally) for 21 days...
2016: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/27633741/postinjury-biomechanics-of-achilles-tendon-vary-by-sex-and-hormone-status
#13
George W Fryhofer, Benjamin R Freedman, Cody D Hillin, Nabeel S Salka, Adam M Pardes, Stephanie N Weiss, Daniel C Farber, Louis J Soslowsky
Achilles tendon ruptures are common injuries. Sex differences are present in mechanical properties of uninjured Achilles tendon, but it remains unknown if these differences extend to tendon healing. We hypothesized that ovariectomized females (OVX) and males would exhibit inferior postinjury tendon properties compared with females. Male, female, and OVX Sprague-Dawley rats (n = 32/group) underwent acclimation and treadmill training before blunt transection of the Achilles tendon midsubstance. Injured hindlimbs were immobilized for 1 wk, followed by gradual return to activity and assessment of active and passive hindlimb function...
November 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27628204/botulinum-toxin-injection-causes-hyper-reflexia-and-increased-muscle-stiffness-of-the-triceps-surae-muscle-in-the-rat
#14
Jessica Pingel, Jacob Wienecke, Jakob Lorentzen, Jens Bo Nielsen
Botulinum toxin is used with the intention of diminishing spasticity and reducing the risk of development of contractures. Here, we investigated changes in muscle stiffness caused by reflex activity or elastic muscle properties following botulinum toxin injection in the triceps surae muscle in rats. Forty-four rats received injection of botulinum toxin in the left triceps surae muscle. Control measurements were performed on the noninjected contralateral side in all rats. Acute experiments were performed, 1, 2, 4, and 8 wk following injection...
December 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27627685/low-level-laser-therapy-and-cryotherapy-as-mono-and-adjunctive-therapies-for-achilles-tendinopathy-in-rats
#15
Sturla Haslerud, Rodrigo Alvaro Brandão Lopes-Martins, Lúcio Frigo, Jan Magnus Bjordal, Rodrigo Labat Marcos, Ingvill Fjell Naterstad, Liv Heide Magnussen, Jon Joensen
BACKGROUND AND OBJECTIVE: Low-level laser therapy (LLLT) and cryotherapy are widely used treatments in the acute phase of tendon injury. The aim of this study was to investigate the interaction of these two treatments on tendon inflammation and mechanical properties. MATERIALS AND METHODS: Six groups of six Wistar rats were used in this study. The Achilles tendons of the healthy control group were not subjected to injury or treatment. The tendons of the injured nontreated group (ING) were injured, but not treated...
January 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27624935/ring-mesh-model-of-proteoglycan-glycosaminoglycan-chains-in-tendon-based-on-three-dimensional-reconstruction-by-focused-ion-beam-scanning-electron-microscopy
#16
Takafumi Watanabe, Kiyokazu Kametani, Yoh-Ichi Koyama, Daisuke Suzuki, Yasutada Imamura, Kazushige Takehana, Kohzy Hiramatsu
Tendons are composed of collagen fibrils and proteoglycan predominantly consisting of decorin. Decorin is located on the d-band of collagen fibrils, and its glycosaminoglycan (GAG) chains have been observed between collagen fibrils with transmission electron microscopy. GAG chains have been proposed to interact with each other or with collagen fibrils, but its three-dimensional organization remains unclear. In this report, we used focused ion beam scanning electron microscopy to examine the three-dimensional organization of the GAG chain in the Achilles tendon of mature rats embedded in epoxy resin after staining with Cupromeronic blue, which specifically stains GAG chains...
November 4, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27624782/photobiomodulation-therapy-on-collagen-type-i-and-iii-vascular-endothelial-growth-factor-and-metalloproteinase-in-experimentally-induced-tendinopathy-in-aged-rats
#17
Anna Cristina de Farias Marques, Regiane Albertini, Andrey Jorge Serra, Evela Aparecida Pereira da Silva, Vanessa Lima Cavalcante de Oliveira, Luciana Miatto Silva, Ernesto Cesar Pinto Leal-Junior, Paulo de Tarso Camillo de Carvalho
This study investigates the effect of photobiomodulation therapy (PBMT) on collagen type I and III, matrix metalloproteinase (MMP), and vascular endothelial growth factor (VEGF) in experimentally induced tendinopathy in female aged rats. Tendinopathy was induced by the Achilles tendoncollagenase peritendinous. Forty-two Wistar rats (Norvegicus albinus) were used; groups consisted of 36 aged animals (18 months old; mean body weight, 517.7 ± 27.54 g) and 6 adult animals (12 weeks old; mean body weight, 266± 19...
December 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27565969/quantification-of-cell-density-in-rat-achilles-tendon-development-and-application-of-a-new-method
#18
Christian Couppé, René B Svensson, Katja M Heinemeier, Emilie Wøjdemann Thomsen, Monika Lucia Bayer, Lise Christensen, Michael Kjær, S Peter Magnusson, Peter Schjerling
Increased tendon cell nuclei density (TCND) has been proposed to induce tendon mechanical adaptations. However, it is unknown whether TCND is increased in tendon tissue after mechanical loading and whether such an increase can be quantified in a reliable manner. The aim of this study was to develop a reliable method for quantification of TCND and to investigate potential changes in TCND in rat Achilles tendons in response to 12 weeks of running. Eight adult male Sprague-Dawley rats ran (RUN) on a treadmill with 10° incline, 1 h/day, 5 days/wk (17-20 m/min) for 12 weeks (which improved tendon mechanical properties) and were compared with 11 control rats (SED)...
January 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/27556387/high-voltage-pulsed-current-in-collagen-realignment-synthesis-and-angiogenesis-after-achilles-tendon-partial-rupture
#19
Érika P Rampazo, Richard E Liebano, Carlos Eduardo Pinfildi, Roberta A C Folha, Lydia M Ferreira
OBJECTIVE: To verify the efficacy of high voltage pulsed current in collagen realignment and synthesis and in angiogenesis after the partial rupturing of the Achilles tendon in rats. METHOD: Forty male Wistar rats were randomized into four groups of 10 animals each: sham, cathodic stimulation, anodic stimulation, and alternating stimulation. Their Achilles tendons were submitted to direct trauma by a free-falling metal bar. Then, the treatment was administered for six consecutive days after the injury...
July 2016: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/27548063/dose-related-and-time-dependent-development-of-collagenase-induced-tendinopathy-in-rats
#20
Carlotta Perucca Orfei, Arianna B Lovati, Marco Viganò, Deborah Stanco, Marta Bottagisio, Alessia Di Giancamillo, Stefania Setti, Laura de Girolamo
Tendinopathy is a big burden in clinics and it represents 45% of musculoskeletal lesions. Despite the relevant social impact, both pathogenesis and development of the tendinopathy are still under-investigated, thus limiting the therapeutic advancement in this field. The purpose of this study was to evaluate the dose-dependent and time-related tissue-level changes occurring in a collagenase-induced tendinopathy in rat Achilles tendons, in order to establish a standardized model for future pre-clinical studies...
2016: PloS One
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