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Intraparenchymal hemorrhage

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https://www.readbyqxmd.com/read/29468581/a-lateral-fluid-percussion-injury-model-for-studying-traumatic-brain-injury-in-rats
#1
Paige S Katz, Patricia E Molina
Traumatic brain injury (TBI) diagnoses have increased in frequency during the past decade, becoming a silent epidemic. The pathophysiology of TBI involves pathophysiological processes affecting the brain, induced by traumatic biomechanical forces resulting in temporary impairment of neurological function. Preclinical models have been generated to recapitulate the mechanical, neuroinflammatory, and behavioral outcomes observed in the clinical setting. The lateral fluid percussion (LFP) model is the most extensively used and well-characterized model of nonpenetrating and nonischemic TBI...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29452322/end-stage-liver-disease-in-patients-with-intracranial-hemorrhage-is-associated-with-increased-mortality-a-cohort-study
#2
Carlito Lagman, Daniel T Nagasawa, John P Sheppard, Cheng Hao Jacky Chen, Thien Nguyen, Giyarpuram N Prashant, Tianyi Niu, Alexander M Tucker, Won Kim, Nader Pouratian, Fady M Kaldas, Ronald W Busuttil, Isaac Yang
BACKGROUND: End-stage liver disease (ESLD) is a devastating consequence of hepatocyte destruction that is associated with intracranial hemorrhage (ICH). OBJECTIVE: To determine if ESLD in patients with ICH is associated with increased mortality. METHODS: We performed a single-center, retrospective cohort study of 53 patients (33 ESLD and 20 non-ESLD patients) who received neurosurgical care between 2006 and 2017. The exposure of interest was ESLD defined clinically as severely impaired liver function and at least one major complication of liver failure...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29439265/natural-history-of-vertebrobasilar-dolichoectatic-and-fusiform-aneurysms-a-systematic-review-and-meta-analysis
#3
Deena M Nasr, Kelly D Flemming, Giuseppe Lanzino, Harry J Cloft, David F Kallmes, Mohammad Hassan Murad, Waleed Brinjikji
BACKGROUND AND PURPOSE: Vertebrobasilar non-saccular and dolichoectatic aneurysms (VBDA) are a rare type of aneurysm and are generally associated with poor prognosis. In order to better characterize the natural history of VBDAs, we performed a systematic review and meta-analysis of the literature to determine rates of mortality, growth, rupture, ischemia, and intraparenchymal hemorrhage. MATERIALS AND METHODS: We searched the literature for longitudinal natural history studies of VBDA patients reporting clinical and imaging outcomes...
February 13, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29397452/update-on-the-treatment-of-spontaneous-intraparenchymal-hemorrhage-medical-and-interventional-management
#4
REVIEW
Thomas J Cusack, J Ricardo Carhuapoma, Wendy C Ziai
PURPOSE OF REVIEW: Spontaneous intraparenchymal hemorrhage (IPH) is a prominent challenge faced globally by neurosurgeons, neurologists, and intensivists. Over the past few decades, basic and clinical research efforts have been undertaken with the goal of delineating biologically and evidence-based practices aimed at decreasing mortality and optimizing the likelihood of meaningful functional outcome for patients afflicted with this devastating condition. Here, the authors review the medical and surgical approaches available for the treatment of spontaneous intraparenchymal hemorrhage, identifying areas of recent progress and ongoing research to delineate the scope and scale of IPH as it is currently understood and treated...
February 3, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29390574/a-case-report-of-parenchymal-hematoma-after-intravenous-thrombolysis-in-a-rivaroxaban-treated-patient-is-it-a-true-rivaroxaban-hemorrhagic-complication
#5
Eugenia Rota, Gianluca Bruzzone, Sergio Agosti, Roberto Pastorino, Nicola Morelli
RATIONALE: To date, the only treatment approved for acute ischemic strokes is thrombolysis. Whether intravenous thrombolysis may be safe in patients taking direct oral anticoagulants (DOACs) is currently a matter of debate. PATIENT CONCERNS: A 74-year-old woman, who was on rivaroxaban 20 mg/d for nonvalvular atrial fibrillation, was admitted to our stroke unit with left-sided hemiparesis and aphasia. The onset of neurologic deficits had occurred 5 hours after the last rivaroxaban dose...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29356856/ruptured-middle-cerebral-artery-aneurysms-with-a-concomitant-intraparenchymal-hematoma-the-role-of-hematoma-volume
#6
I A Zijlstra, W E van der Steen, D Verbaan, C B Majoie, H A Marquering, B A Coert, W P Vandertop, R van den Berg
PURPOSE: To study whether clinical outcome data from our patient cohort could give support to the new recommendation in the AHA/ASA guidelines for the management of aneurysmal subarachnoid hemorrhage that states "that microsurgical clipping may receive increased consideration in patients with ruptured middle cerebral artery (MCA) aneurysms and large (>50 mL) intraparenchymal hematomas", while clinical outcome data supporting this recommendation are sparse. METHODS: We reviewed the clinical and radiological data of 81 consecutive patients with MCA aneurysms and concomitant hematomas admitted between January 2006 and December 2015...
January 22, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29338544/a-direct-comparison-between-norepinephrine-and-phenylephrine-for-augmenting-spinal-cord-perfusion-in-a-porcine-model-of-spinal-cord-injury
#7
Femke Streijger, Kitty So, Neda Manouchehri, Ana Gheorghe, Elena B Okon, Ryan M Chan, Benjamin Ng, Katelyn Shortt, Mypinder Singh Sekhon, Donald E Griesdale, Brian K Kwon
Current clinical guidelines recommend elevating the mean arterial blood pressure (MAP) to increase spinal cord perfusion in patients with acute spinal cord injury (SCI). This is typically achieved with vasopressors such as norepinephrine (NE) and phenylephrine (PE). These drugs differ in their pharmacologic properties and potentially have different effects on spinal cord blood flow (SCBF), oxygenation (PO2), and downstream metabolism after injury. Using a porcine model of thoracic SCI, we evaluated how these vasopressors influenced intraparenchymal SCBF, PaPO2, hydrostatic pressure, and metabolism within the spinal cord adjacent to the injury site...
January 16, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29315100/management-of-an-adolescent-athlete-with-sports-related-concussion-and-intraparenchymal-hemorrhage
#8
Michael J Ellis, Jeffrey Barnes, Dean M Cordingley, Martin Bunge, Patrick J McDonald, Lesley Ritchie
No abstract text is available yet for this article.
January 2018: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/29311267/relationship-between-dietary-vitamin-d-and-deaths-from-stroke-and-coronary-heart-disease-the-japan-collaborative-cohort-study
#9
Haytham A Sheerah, Ehab S Eshak, Renzhe Cui, Hironori Imano, Hiroyasu Iso, Akiko Tamakoshi
BACKGROUND AND PURPOSE: There is growing evidence about the importance of vitamin D for cardiovascular health. Therefore, we examined the relationship between dietary vitamin D intake and risk of mortality from stroke and coronary heart disease in Japanese population. METHODS: A prospective study encompassing 58 646 healthy Japanese adults (23 099 men and 35 547 women) aged of 40 to 79 years in whom dietary vitamin D intake was determined via a self-administered food frequency questionnaire...
February 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29303458/complications-following-intracranial-pressure-monitoring-in-children-a-6-year-single-center-experience
#10
Ruichong Ma, David Rowland, Andrew Judge, Amedeo Calisto, Jayaratnam Jayamohan, David Johnson, Peter Richards, Shailendra Magdum, Steven Wall
OBJECTIVE Intracranial pressure (ICP) monitoring is an important tool in the neurosurgeon's armamentarium and is used for a wide range of indications. There are many different ICP monitors available, of which fiber-optic intraparenchymal devices are very popular. Here, the authors document their experience performing ICP monitoring from 2005 to 2015 and specifically complication rates following insertion of the Microsensor ICP monitor. METHODS A retrospective case series review of all patients who underwent ICP monitoring over a 10-year period from 2005 to 2015 was performed...
January 5, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29303442/blossoming-contusions-identifying-factors-contributing-to-the-expansion-of-traumatic-intracerebral-hemorrhage
#11
Joseph A Carnevale, David J Segar, Andrew Y Powers, Meghal Shah, Cody Doberstein, Benjamin Drapcho, John F Morrison, John R Williams, Scott Collins, Kristina Monteiro, Wael F Asaad
OBJECTIVE Traumatic brain injury (TBI) remains a significant cause of neurological morbidity and mortality. Each year, more than 1.7 million patients present to the emergency department with TBI. The goal of this study was to evaluate the prognosis of traumatic cerebral intraparenchymal hemorrhage (tIPH), to develop subclassifications of these injuries that relate to prognosis, and to provide a more comprehensive assessment of hemorrhagic progression contusion (HPC) by analyzing the rate at which tIPH "blossom" (i...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29274446/a-progressively-enlarging-cerebellar-hematoma-concurrent-with-t-dm1-treatment-case-report
#12
Marcelo D Vilela, William T Longstreth, Hugo As Pedrosa, Gabriel Ob Gil, Juliano M Duarte, Marco Antonio D Filho
BACKGROUND: Trastuzumab emtansine, an antibody-drug conjugate commonly abbreviated as T-DM1, is accepted as an effective therapy for trastuzumab-resistant metastatic HER2-positive breast cancer. T-DM1 significantly increases progression-free and overall survival when compared to lapatinib plus capecitabine in patients with HER2-positive breast cancer previously treated with trastuzumab and a taxane. Among the common side effects related to T-DM1, thrombocytopenia and mucosal hemorrhage are seen, although they are infrequently judged to be clinically significant...
December 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29250911/management-of-intracranial-hemorrhage-in-severe-factor-v-deficiency-and-definitive-treatment-with-liver-transplantation
#13
Angelica W DesPain, Anisha Kshetrapal, Youssef A Kousa, Christine Guelcher, Nada A Yazigi, Corina E Gonzalez, Vinh Nguyen, Alexander Kroemer, Stuart S Kaufman, Michael F Guerrera
FV is primarily produced in the liver, and congenital FV deficiency is a disorder with an incidence of one in 1 million. Standard care is to treat severe bleeding phenotypes with FFP as there is no recombinant or plasma-derived FV concentrate. We present a case of a neonate with known severe FV deficiency diagnosed after prolonged bleeding after circumcision who represented at age 2 months with a large left intraparenchymal hemorrhage. His bleed was treated with FFP, platelet transfusion, recombinant VIIa, and emergent evacuation...
December 18, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29245300/treatment-of-the-superior-sagittal-sinus-and-transverse-sinus-thrombosis-associated-with-intracranial-hemorrhage-with-the-mechanical-thrombectomy-and-thrombolytics-case-report
#14
Yuchun Liu, Keqin Li, Yi Huang, Jie Sun, Xiang Gao
RATIONALE: The superior sagittal sinus (SSS) and transverse sinus are the major dural sinuses that receive a considerable amount of venous drainage. The occlusion of them has been suggested to cause intracranial hypertension, hemorrhage, and lead to potentially fatal consequences. PATIENT CONCERNS: We reported a 35-year-old woman with headache presented to our emergency department with a decreased level of consciousness and epileptic seizures. The examination of speech, higher mental function, and cranial nerve were normal...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29231794/intracranial-contrast-transit-times-on-digital-subtraction-angiography-decrease-more-in-patients-with-delayed-intraparenchymal-hemorrhage-after-pipeline
#15
Denise Brunozzi, Sophia F Shakur, Fady T Charbel, Ali Alaraj
Background Pipeline embolization devices (PEDs) are used for endovascular treatment of cerebral aneurysms but can be associated with delayed ipsilateral intraparenchymal hemorrhage (DIPH). Changes in intracranial hemodynamics after PED are poorly understood. Objective Here, we assess hemodynamic changes after PED in patients and compare these changes in patients with and without DIPH (DIPH+ and DIPH-). Methods Records of patients with distal internal carotid artery (ICA) aneurysms treated with PED at our institution between 2012 and 2017 were retrospectively reviewed...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29219758/the-use-of-alternatives-to-clopidogrel-in-flow-diversion-treatment-with-the-pipeline-embolization-device
#16
Elias Atallah, Hassan Saad, Kimon Bekelis, Nohra Chalouhi, Stavropoula Tjoumakaris, David Hasan, Jorge Eller, David Stidd, Robert H Rosenwasser, Pascal Jabbour
OBJECTIVE Thromboembolic complications continue to be encountered with Pipeline embolization devices (PEDs) despite routine clopidogrel/aspirin antiplatelet therapy. This study examined the safety and efficacy of prasugrel in the management of clopidogrel-resistant patients treated for cerebral aneurysms. METHODS Four hundred thirty-seven consecutive patients were identified between January 2011 and May 2016. Patients allergic, or having less than 30% platelet inhibition, to a daily 75-mg dose of clopidogrel received 10 mg of prasugrel daily (n = 20) or 90 mg of ticagrelor twice daily (n = 2)...
December 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29218511/optical-monitoring-of-cerebral-microcirculation-in-neurointensive-care
#17
Peter Rejmstad, Neda Haj-Hosseini, Oscar Åneman, Karin Wårdell
Continuous optical monitoring of local cerebral microcirculation could benefit neurointensive care patients treated for subarachnoid hemorrhage (SAH). The aim of the study was to evaluate laser Doppler flowmetry (LDF) and diffuse reflectance spectroscopy (DRS) for long-term monitoring of brain microcirculation and oxygen saturation (SO2) in the neurointensive care unit (NICU). A fiber optic probe was designed for intraparenchymal use and connected to LDF and DRS for assessment of the local blood flow (perfusion and tissue reflectance (TLI)) and SO2 in the brain...
December 8, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29189631/incidence-and-risk-factors-of-intracranial-hemorrhage-in-liver-transplant-recipients
#18
Tom K Gallagher, Kathryn A Thomas, Daniela P Ladner, Daniel Ganger, Farzaneh A Sorond, Shyam Prabhakaran, Michael M Abecassis, Jonathan P Fryer, Eric M Liotta
BACKGROUND: Intracranial hemorrhage after liver transplantation is an infrequently reported complication but one which can have devastating consequences. METHODS: We performed a retrospective cross-sectional analysis of all liver transplants performed between January 2010 and June 2015 at a single high-volume institution using a prospectively maintained electronic database and query of the electronic medical record. Cases of intracranial hemorrhage were adjudicated as either spontaneous intraparenchymal (IPH) or extra-axial (EAH) hemorrhages...
November 17, 2017: Transplantation
https://www.readbyqxmd.com/read/29147151/percutaneous-direct-embolization-for-pseudoaneurysm-at-the-gallbladder-fossa-after-cholecystectomy
#19
Kunihiro Yagihashi, Minobu Kamo, Tomoya Nishiyama, Yasuyuki Kurihara
Postoperative pseudoaneurysm at the gallbladder fossa is a rare complication of cholecystectomy. The typical clinical presentations of this condition are intraparenchymal or intraperitoneal hemorrhage or rupture into the gastrointestinal tract, and this may be life-threatening. For the treatment of pseudoaneurysms, percutaneous transarterial embolization is considered first-line. We present a case of pseudoaneurysm at the gallbladder following cholecystectomy, which was successfully treated with echo-guided percutaneous transhepatic direct embolization using N-butyl cyanoacrylate, after the failure of transarterial embolization...
September 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29084284/a-novel-multicolor-flow-cytometry-application-for-quantitative-detection-of-receptors-on-vascular-smooth-muscle-cells
#20
Aneta Radziwon-Balicka, Matilda Degn, Sara E Johansson, Karin Warfvinge, Lars Edvinsson
There is a need to develop new techniques for quantitative measurement of receptors expression on particular vasculature cells types. Here, we describe and demonstrate a novel method to measure quantitatively and simultaneously the expression of endothelin B receptor (ETB) on vascular smooth muscle cells (VSMC). We isolated cells from male rat tissues such as: brain pial, brain intraparenchymal and retina vessels. To analyze solid tissues, a single-cell suspension was prepared by a combined mechanic and enzymatic process...
2017: PloS One
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