Liangliang Tian, Guangzhao Cao, Xiaotong Zhu, Lihan Wang, Jingyi Hou, Yi Zhang, He Xu, Lixia Wang, Shicong Wang, Chen Zhao, Hongjun Yang, Jingjing Zhang
As a famous prescription in China, AnGong NiuHuang (AGNH) pill exerts good neuroprotection for ischaemic stroke (IS), but its mechanism is still unclear. In this study, the neuroprotection of AGNH was evaluated in the rat IS model which were established with the surgery of middle cerebral artery occlusion (MCAO), and the potential mechanism was elucidated by transcriptomic analysis and metabolomic analysis. AGNH treatment obviously decreased the infarct volume and Zea-Longa 5-point neurological deficit scores, improved the survival percentage of rats, regional cerebral blood flow (rCBF), and rat activity distance and activity time...
February 24, 2024: Molecular Neurobiology