keyword
https://read.qxmd.com/read/38436166/evaluation-of-the-healing-and-protective-properties-of-adipose-derived-mesenchymal-stem-cells-from-cisplatin-induced-liver-and-kidney-damage
#1
JOURNAL ARTICLE
M Ürün, E S Bora, H Acar, O Erbaş
OBJECTIVE: The occurrence of nephrotoxicity and hepatotoxicity as a result of cisplatin administration is a major concern in clinical practice. This study examined the potential protective effects of administering mesenchymal stem cells (MSCs) on the renal and hepatic damage caused by cisplatin. Moreover, the study investigated the potential protective effects of administering Adipose-Derived Mesenchymal Stem Cells (ADMSC) to counteract the harmful effects of cisplatin-induced kidney and liver damage...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38401045/transcriptomics-and-metabolomics-unveil-the-neuroprotection-mechanism-of-angong-niuhuang-agnh-pill-against-ischaemic-stroke-injury
#2
JOURNAL ARTICLE
Liangliang Tian, Guangzhao Cao, Xiaotong Zhu, Lihan Wang, Jingyi Hou, Yi Zhang, He Xu, Lixia Wang, Shicong Wang, Chen Zhao, Hongjun Yang, Jingjing Zhang
As a famous prescription in China, AnGong NiuHuang (AGNH) pill exerts good neuroprotection for ischaemic stroke (IS), but its mechanism is still unclear. In this study, the neuroprotection of AGNH was evaluated in the rat IS model which were established with the surgery of middle cerebral artery occlusion (MCAO), and the potential mechanism was elucidated by transcriptomic analysis and metabolomic analysis. AGNH treatment obviously decreased the infarct volume and Zea-Longa 5-point neurological deficit scores, improved the survival percentage of rats, regional cerebral blood flow (rCBF), and rat activity distance and activity time...
February 24, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38353687/nebivolol-protects-the-liver-against-lipopolysaccharide-induced-oxidative-stress-inflammation-and-endoplasmic-reticulum-related-apoptosis-through-chop-and-bip-grp78-signaling
#3
JOURNAL ARTICLE
Onur Unal, Yalcin Erzurumlu, Halil Asci, Berivan Gunduru Acar, Mehmet Bedir, Ozlem Ozmen
This study aimed to examine the protective role of nebivolol (NEB) on liver tissue against the lipopolysaccharide (LPS)-induced sepsis model in rats by targeting endoplasmic reticulum (ER) stress-related binding immunoglobulin protein (Bip), CCAAT-enhancer-binding protein homologous protein (Chop) signaling pathways. Four groups, each comprising eight rats, were established: control, LPS, LPS + NEB, and NEB. Biochemical analyses included total oxidant status (TOS), serum aspartate transaminase (AST), and alanine aminotransferase (ALT) levels...
February 14, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38313882/lagerstroemia-speciosa-pers-lythraceae-ethanolic-extract-attenuates-isoniazid-induced-oxidative-stress-and-hepatic-inflammation-in-rats
#4
JOURNAL ARTICLE
T Rohit Singh, Devaraj Ezhilarasan, Munusamy Karthick, Karthik Shree Harini
Background Drug-induced liver injury is a common cause of acute liver failure. Isoniazid (INH) is used as a first-line treatment for tuberculosis. Clinical and experimental studies have reported abnormal liver function after INH therapy. Lagerstroemia speciosa Pers., commonly known as banaba, has been traditionally used to treat various ailments including diabetes and obesity due to its antioxidant and anti-inflammatory properties. Aim To investigate the hepatoprotective effect of ethanolic banaba leaf extract (EBLE) against INH-induced hepatotoxicity in rats...
January 2024: Curēus
https://read.qxmd.com/read/38171054/isobavachalcone-attenuates-liver-fibrosis-via-activation-of-the-nrf2-ho-1-pathway-in-rats
#5
JOURNAL ARTICLE
Xiangshu Wang, Haozhe Tian, Jie Chen, Di Huang, Feng Ding, Tao Ma, Jin Xi, Chengzhu Wu, Yuxin Zhang
Liver fibrosis, a progression of chronic liver disease, is a significant concern worldwide due to the lack of effective treatment modalities. Recent studies have shown that natural products play a crucial role in preventing and treating liver fibrosis. Isobavachalcone (IBC) is a chalcone compound with anti-inflammatory, antioxidant, and anti-cancer properties. However, its potential antifibrotic effects remain to be elucidated. This study aimed to investigate the antifibrotic effects of IBC on liver fibrosis and its underlying mechanisms in rats...
January 2, 2024: International Immunopharmacology
https://read.qxmd.com/read/38062240/silver-nanoparticles-synthesized-by-probiotic-bacteria-and-antibacterial-role-in-resistant-bacteria
#6
JOURNAL ARTICLE
Eman Khalifa, Mohamed Abdel Rafea, Nazir Mustapha, Rania Sultan, ElSayed Hafez
Many dangerous bacteria have become highly resistant to traditional antibiotics, which is a huge public health concern. This study investigated the use of silver nanoparticles biosynthesized in a culture filtrate of Lactobacillus acidophilus as antimicrobials. UV-visual spectrophotometry, Fourier-transform-infrared spectroscopy, X-ray power diffraction, and scanning electron microscopy have all validated the findings. The biosynthesized nanoparticles ranged in size from 33 to 90 nm. The cytotoxicity of the nanosilver generated was then investigated using nine 200 g BW rats separated into three groups...
December 7, 2023: AMB Express
https://read.qxmd.com/read/38004149/esculeogenin-a-a-glycan-from-tomato-alleviates-nonalcoholic-fatty-liver-disease-in-rats-through-hypolipidemic-antioxidant-and-anti-inflammatory-effects
#7
JOURNAL ARTICLE
Jwharah M Al Jadani, Nawal A Albadr, Ghedeir M Alshammari, Soheir A Almasri, Farah Fayez Alfayez, Mohammed Abdo Yahya
This study examined the preventative effects of esculeogenin A (ESGA), a newly discovered glycan from tomato, on liver damage and hepatic steatosis in high-fat-diet (HFD)-fed male rats. The animals were divided into six groups (each of eight rats): a control group fed a normal diet, control + ESGA (200 mg/kg), HFD, and HFD + ESAG in 3 doses (50, 100, and 200 mg/kg). Feeding and treatments were conducted for 12 weeks. Treatment with ESGA did not affect gains in the body or fat weight nor increases in fasting glucose, insulin, and HOMA-IR or serum levels of free fatty acids (FFAs), tumor-necrosis factor-α, and interleukin-6 (IL-6)...
November 11, 2023: Nutrients
https://read.qxmd.com/read/37827298/the-anti-liver-fibrosis-effect-of-tibetan-medicine-qiwei-tiexie-capsule-is-related-to-the-inhibition-of-nlrp3-inflammasome-activation-in-vivo-and-in-vitro
#8
JOURNAL ARTICLE
Shanshan Wang, Fei Ye, Qingjia Ren, Shengnan Sun, Weina Xia, Zhuwei Wang, Haolin Guo, Han Li, Shujing Zhang, Scott Lowe, Meng Chen, Qinghong Du, Weihong Li
ETHNOPHARMACOLOGICAL RELEVANCE: Qiwei Tiexie capsule (QWTX) is an improved form of a classical prescription of Tibetan medicine-Qiwei Tiexie pill. It has been employed in the treatment of a variety of chronic liver disorders, including liver fibrosis. Uncertainty still exists regarding the mechanism of QWTX action in liver fibrosis. AIM OF THE STUDY: Confirm the anti-liver fibrosis effect of QWTX and reveal its mechanism from the perspective of NOD-like receptor protein 3 (NLRP3) inflammasome activation...
October 10, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37660955/jianpi-shengqing-huazhuo-formula-improves-abnormal-glucose-and-lipid-metabolism-in-obesity-by-regulating-mitochondrial-biogenesis
#9
JOURNAL ARTICLE
Wenkai Wang, Shanshan Chen, Shuting Xu, Guangyi Liao, Weihao Li, Xiao Yang, Tingting Li, Huifen Zhang, Huanhuan Huang, Yuqing Zhou, Huafeng Pan, Chuanquan Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Jianpi Shengqing Huazhuo Formula (JSH) is a modified prescription based on traditional Chinese medicine theory and classic prescriptions (Buzhong Yiqi Decoction and Yuye Decoction). It has been found that JSH has a good effect on obese patients with early abnormal glucose and lipid metabolism. Therefore, this experiment was conducted to study its clinical efficacy and pharmacological effect. AIM OF THE STUDY: To observe the clinical efficacy of JSH and explore the mechanism of the formula to improve glucose and lipid metabolism in obese rats...
September 1, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37655263/melatonin-downregulates-the-increased-hepatic-alpha-fetoprotein-expression-and-restores-pancreatic-beta-cells-in-a-streptozotocin-induced-diabetic-rat-model-a-clinical-biochemical-immunohistochemical-and-descriptive-histopathological-study
#10
JOURNAL ARTICLE
Khalaf F Alsharif, Asmaa A Hamad, Mohamed A Alblihd, Fatma Abo Zakaib Ali, Sherine Ahmed Mohammed, Abdulrahman Theyab, Osama M Al-Amer, Malik Saad Almuqati, Abdulraheem Ali Almalki, Alaa Jameel A Albarakati, Khalid J Alzahrani, Ashraf Albrakati, Mohammad Hamed Albarakati, Doaa Abass, Maha S Lokman, Ehab Kotb Elmahallawy
BACKGROUND: Diabetes mellitus (DM) is a chronic metabolic disorder. Hepatopathy is one of the serious effects of DM Melatonin (MT) is a potent endogenous antioxidant that can control insulin output. However, little information is available about the potential association between melatonin and hepatic alpha-fetoprotein expression in diabetes. OBJECTIVE: This study was conducted to assess the influence of MT on diabetes-related hepatic injuries and to determine how β-cells of the pancreas in diabetic rats respond to MT administration...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37635578/mesna-2-mercaptoethanesulfonate-attenuates-brain-heart-and-lung-injury-induced-by-carotid-ischemia-reperfusion-in-rats
#11
JOURNAL ARTICLE
M Mercan, A O Sehirli, C Gultekin, U Chukwunyere, S Sayiner, S Gencosman, S Cetinel, N Abacioglu
BACKGROUND: Ischemia-reperfusion (I/R) causes organ dysfunction as a result of the increased formation of various reactive oxygen metabolites, infiltration of inflammatory cells, interstitial edema, cellular dysfunction, and tissue death. AIM: The study aimed to investigate the cytoprotective effect of 2-mercaptoethanesulfonate (MESNA) against tissue damage in rats exposed to carotid ischemia-reperfusion. MATERIALS AND METHODS: Twenty-four male Wistar albino rats were divided into four groups (n = 6): sham, carotid I/R, I/R + MESNA (75 mg/kg), and I/R + MESNA (150 mg/kg) groups...
July 2023: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/37569578/parkinson-s-disease-and-the-heart-studying-cardiac-metabolism-in-the-6-hydroxydopamine-model
#12
JOURNAL ARTICLE
Victor Silva da Fonsêca, Valeria de Cassia Goncalves, Mario Augusto Izidoro, Antônio-Carlos Guimarães de Almeida, Fernando Luiz Affonso Fonseca, Fulvio Alexandre Scorza, Josef Finsterer, Carla Alessandra Scorza
Parkinson's-disease (PD) is an incurable, age-related neurodegenerative disease, and its global prevalence of disability and death has increased exponentially. Although motor symptoms are the characteristic manifestations of PD, the clinical spectrum also contains a wide variety of non-motor symptoms, which are the main cause of disability and determinants of the decrease in a patient's quality of life. Noteworthy in this regard is the stress on the cardiac system that is often observed in the course of PD; however, its effects have not yet been adequately researched...
July 30, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37553303/mice-rats-and-guinea-pigs-exhibit-significant-variations-in-the-plasma-urine-and-tissue-levels-of-taurine-betaine-sarcosine-and-other-osmolyte-active-amino-acids
#13
JOURNAL ARTICLE
Lenka Tomasova, Klaudia Maksymiuk, Dawid Chabowski, Emilia Samborowska, Marcin Ufnal
BACKGROUND: Osmolytes are naturally occurring compounds that protect cells from osmotic stress in high-osmolarity tissues, such as the kidney medulla. Some amino acids, including taurine, betaine, glycine, alanine, and sarcosine, are known to act as osmolytes. This study aimed to establish the levels of these amino acids in body fluids and tissues of laboratory animals used as models for human diseases in biomedical research. METHODS: Liquid chromatography coupled with mass spectrometry was used to quantify taurine, glycine, betaine, alanine, beta-alanine, and sarcosine in plasma, urine, and tissues of adult, male mice, rats and guinea pigs...
August 2023: Discovery Medicine
https://read.qxmd.com/read/37475002/-effect-of-processing-with-vinegar-on-efficacy-of-curcuma-longa-in-treatment-of-dysmenorrhea-in-rats-with-syndrome-of-liver-depression-and-qi-stagnation
#14
JOURNAL ARTICLE
Jie Wu, Ma-Yi-Jie Cao, Ying Peng, Bao-Hua Dong, Yun-Xiu Jiang, Peng-Jin Zhu, Chang-Jiang Hu, Run-Chun Xu, Zhi-Min Chen
This study compared the effects of Curcuma longa before and after processing with vinegar on the rat model of dysmenorrhea with the syndrome of liver depression and Qi stagnation to reveal the mechanism of vinegar processing in improving the role of C. longa in soothing liver and relieving pain. The rat model of dysmenorrhea with the syndrome of liver depression and Qi stagnation was established according to the Preparation of the Animal Model of Dysmenorrhea(Draft) and the chronic unpredictable stress me-thod...
July 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/37449749/high-cholesterol-diet-in-combination-with-hydroxypropyl-beta-cyclodextrin-induces-nash-like-disorders-in-the-liver-of-rats
#15
JOURNAL ARTICLE
Y Saigo, T Sasase, M Tohma, K Uno, Y Shinozaki, T Maekawa, R Sano, K Miyajima, T Ohta
Non-alcoholic fatty liver disease (NAFLD) is a general term for fatty liver disease not caused by viruses or alcohol. Fibrotic hepatitis, cirrhosis, and hepatocellular carcinoma can develop. The recent increase in NAFLD incidence worldwide has stimulated drug development efforts. However, there is still no approved treatment. This may be due in part to the fact that non-alcoholic steatohepatitis (NASH) pathogenesis is very complex, and its mechanisms are not well understood. Studies with animals are very important for understanding the pathogenesis...
July 14, 2023: Physiological Research
https://read.qxmd.com/read/37367046/antioxidant-flavonoid-diosmetin-is-cardioprotective-in-a-rat-model-of-myocardial-infarction-induced-by-beta-1-adrenergic-receptors-activation
#16
JOURNAL ARTICLE
Taseer Ahmad, Taous Khan, Annet Kirabo, Abdul Jabbar Shah
Myocardial infarction (MI) is a common and life-threatening manifestation of ischemic heart diseases (IHD). The most important risk factor for MI is hypertension. Natural products from medicinal plants have gained considerable attention globally due to their preventive and therapeutic effects. Flavonoids have been found to be efficacious in ischemic heart diseases (IHD) by alleviating oxidative stress and beta-1 adrenergic activation, but the mechanistic link is not clear. We hypothesized that antioxidant flavonoid diosmetin is cardioprotective in a rat model of MI induced by beta 1-adrenergic receptor activation...
May 29, 2023: Current Issues in Molecular Biology
https://read.qxmd.com/read/37286116/porcine-cardiac-blood-salvia-miltiorrhiza-root-alleviates-cerebral-ischemia-reperfusion-injury-by-inhibiting-oxidative-stress-induced-apoptosis-through-pi3k-akt-bcl-2-bax-signaling-pathway
#17
JOURNAL ARTICLE
Shikang Zhou, Xiaoqin Gao, Can Chen, Jinyun Zhang, Yi Zhang, Li Zhang, Xiaojing Yan
ETHNOPHARMACOLOGICAL RELEVANCE: Salvia miltiorrhiza Bge. mixed with porcine cardiac blood (PCB-DS) is mainly employed for the treatment of brain ischemia-induced mental disturbances, palpitations and phlegm confusion based on the traditional principle of Menghe medical sect. PCB is the guide to DS and enhances the effect of DS. However, the potential mechanism of PCB-DS preventing cerebral ischemia/reperfusion injury (CIRI) from the perspective of oxidative stress induced cell apoptosis remains unknown...
June 5, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37251265/ellagic-acid-from-whole-pomegranate-fruit-reduces-liver-injury-in-a-rat-model-of-hepatic-cholestasis
#18
JOURNAL ARTICLE
Ratna Widyawati, Wiwik Misaco Yuniarti, Bambang Sektiari Lukiswanto
BACKGROUND: Cholestasis is a health problem, both in humans and animals, which in the disease's course involves oxidative stress, inflammation, and liver fibrosis. EA has been proven to have beneficial effects on various diseases. AIM: This study was conducted to determine the effect of EA in protecting liver damage because of cholestasis. In addition, to understand the underlying mechanism of liver damage in rats as a model animal by bile duct ligation (BDL) technique...
April 2023: Open Veterinary Journal
https://read.qxmd.com/read/37188238/consumption-of-barley-bread-rich-in-beta-glucan-during-an-overfeeding-improves-the-serum-lipid-profile-and-balances-the-intestinal-microbiota-in-wistar-rats
#19
JOURNAL ARTICLE
Bouaziz Kaoutar, Belkaaloul Kawthar, Kheroua Omar
UNLABELLED: This paper aims to study the preventive effect of barley consumption on lipid disorders associated to obesity during a high-fat-diet. In this study, Eighteen (18) male Wistar rats (142.63 ± 5 g) were divided into 3 equal groups. Indeed, the first received a standard diet (C), the second received a high-fat-diet containing an Ordinary Bread (OB) and the third received the same high-fat-diet only the OB was replaced by Barley Bread (BB). The weight of rats was measured weekly, after 12 weeks of diet, the rats were sacrificed, the lipid and hepatic assays were performed...
March 2023: Indian Journal of Microbiology
https://read.qxmd.com/read/37070884/ameliorative-effect-of-arabic-gum-acacia-and-mori-extracts-in-streptozotocin-induced-diabetic-rats-implications-of-cas-3-and-tgf-%C3%AE
#20
JOURNAL ARTICLE
R A El-Shafei, M A El-Adl, H S Ali, Y Nomier
OBJECTIVE: Arabic gum Acacia (AG) is rich in fiber which improves lipid metabolism besides its antioxidant effect. Folium mori (FM) is a widely used herb due to its immunomodulatory, antimicrobial, and antioxidant activity. In the current study, we explore the antidiabetic, anti-inflammatory, as well as antioxidant activities of AG and FM in Streptozotocin (STZ), induced diabetic rats. MATERIALS AND METHODS: STZ diabetic rats were orally administrated with metformin and/or a combination of AG and FM for 4 weeks...
April 2023: European Review for Medical and Pharmacological Sciences
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