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Mary A S Melo, Michael D Weir, Vanara F Passos, Michael Powers, Hockin H K Xu
Enamel demineralization is destructive, esthetically compromised, and costly complications for orthodontic patients. Nano-sized amorphous calcium phosphate (NACP) has been explored to address this challenge. The 20% NACP-loaded ortho-cement notably exhibited favorable behavior on reducing demineralization of enamel around brackets in a caries model designed to simulate the carious attack. The 20% NACP-loaded ortho-cement markedly promotes higher calcium and phosphate release at a low pH, and the mineral loss was almost two fold lower and carious lesion depth decreased the by 1/3...
February 21, 2017: Artificial Cells, Nanomedicine, and Biotechnology
Sukarma Tanwar, B B Rewari, Cv Dharma Rao, Nicole Seguy
Over the last two decades, India's National AIDS Control Programme (NACP) has evolved and expanded to provide HIV prevention, testing and treatment services countrywide. Scaling up has been uniform across all strategic components and has not only halted, but also reversed, the spread of the epidemic and ensured a major reduction in the number of AIDS-related annual deaths. As the epidemic has been driven by key populations, there was a special focus on these groups from the outset, with various innovative strategies for prevention and testing services...
November 28, 2016: Journal of Virus Eradication
Lin Wang, Xianju Xie, Chunyan Li, Huaibing Liu, Ke Zhang, Yanmin Zhou, Xiaofeng Chang, Hockin H K Xu
OBJECTIVE: The objectives of this study were to: (1) develop a bioactive endodontic sealer via dimethylaminohexadecyl methacrylate (DMAHDM), 2-methacryloyloxyethyl phosphorylcholine (MPC) and nanoparticles of amorphous calcium phosphate (NACP) for the first time; and (2) evaluate inhibition of early-stage and mature multispecies endodontic biofilm, bond strength to root canal dentin, and calcium (Ca) and phosphate (P) ion release. METHODS: A series of bioactive endodontic sealers were formulated with DMAHDM, MPC, and NACP...
February 18, 2017: Journal of Dentistry
Gobika Thiripuranathar, Antony P Y Chan, Dipendu Mandal, Wing Y Man, Mario Argentari, Georgina M Rosair, Alan J Welch
Double deboronation of 1,1'-bis(ortho-carborane) results in a mixture of racemic and meso diastereoisomers which are sources of the [7-(7'-7',8'-nido-C2B9H10)-7,8-nido-C2B9H10](4-) tetraanion. Consistent with this, metalation of the mixture with {Ru(p-cymene)} affords the diastereoisomers α-[1-(8'-2'-(p-cymene)-2',1',8'-closo-RuC2B9H10)-3-(p-cymene)-3,1,2-closo-RuC2B9H10] (3α) and β-[1-(8'-2'-(p-cymene)-2',1',8'-closo-RuC2B9H10)-3-(p-cymene)-3,1,2-closo-RuC2B9H10] (3β) in which the primed cage has undergone a spontaneous 3',1',2' to 2',1',8'-RuC2B9 isomerisation...
January 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Kunneng Liang, Michael D Weir, Mark A Reynolds, Xuedong Zhou, Jiyao Li, Hockin H K Xu
The objectives of this study were to develop a novel method to remineralize dentin lesions, and investigate the remineralization effects of poly (amido amine) (PAMAM) dendrimer plus a bonding agent with nanoparticles of amorphous calcium phosphate (NACP) in a cyclic artificial saliva/lactic acid environment for the first time. Dentin lesions were produced via phosphoric acid. Four groups were tested: (1) dentin control, (2) dentin with PAMAM, (3) dentin with NACP bonding agent, and (4) dentin with PAMAM plus NACP bonding agent...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Keith C Armstrong, Stephan Hohloch, Trevor D Lohrey, Ryan A Zarkesh, John Arnold, Mitchell R Anstey
The first synthesis of anion capped cerium corrole complexes is reported. Unusual clustering of the lanthanide corrole units has been found and the degree of aggregation can be controlled by the choice of the capping ligand. A polymeric structure 1a, with the general formula [Cor-Ce(THF)-Cp-Na]n (Cor = 5,15-bis(2,4,6-trimethylphenyl)-10-(4 methoxyphenyl)-corrole, THF = tetrahydrofuran), is formed using sodium cyclopentadienide (NaCp) and a dimeric structure 2a, with the general formula [Cor-Ce-Tp]2, is formed when potassium tris(pyrazolyl)borate (KTp) is used...
November 22, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Xian-Ju Xie, Dan Xing, Lin Wang, Han Zhou, Michael D Weir, Yu-Xing Bai, Hockin Hk Xu
White spot lesions (WSLs), due to enamel demineralization, occur frequently in orthodontic treatment. We recently developed a novel rechargeable dental composite containing nanoparticles of amorphous calcium phosphate (NACP) with long-term calcium (Ca) and phosphate (P) ion release and caries-inhibiting capability. The objectives of this study were to develop the first NACP-rechargeable orthodontic cement and investigate the effects of recharge duration and frequency on the efficacy of ion re-release. The rechargeable cement consisted of pyromellitic glycerol dimethacrylate (PMGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA)...
November 4, 2016: International Journal of Oral Science
Lin Wang, Mary A S Melo, Michael D Weir, Xianju Xie, Mark A Reynolds, Hockin H K Xu
OBJECTIVES: The occurrence of tooth root caries is increasing as the world population ages and tooth retention in seniors increases. Class V restorations with subgingival margins are difficult to clean and often lead to periodontitis. The objectives of this study were to develop a Class V composite containing dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP), and investigate mechanical properties and the inhibition of six species of periodontitis-related biofilms for the first time...
December 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Kunneng Liang, Michael D Weir, Xianju Xie, Lin Wang, Mark A Reynolds, Jiyao Li, Hockin H K Xu
OBJECTIVES: The objective of this study was to investigate the effects of poly (amido amine) (PAMAM), composite with nanoparticles of amorphous calcium phosphate (NACP), and the combined PAMAM+NACP nanocomposite treatment, on remineralization of demineralized dentin in a cyclic artificial saliva/lactic acid environment for the first time. METHODS: Dentin specimens were prepared and demineralized with 37% phosphoric acid for 15s. Four groups were prepared: (1) dentin control, (2) dentin coated with PAMAM, (3) dentin with NACP composite, (4) dentin with PAMAM+NACP...
September 22, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Jonathan Mensah Dapaah, Rachel Spronk
With the upscaling of antiretroviral therapy (ART) in resource-poor countries, many HIV-positive persons in Ghana have been accessing treatment in hospitals. Prevalence is relatively low compared to other African countries, 1.30%. HIV/AIDS remains heavily stigmatised in Ghana, which influences the provision and use of ART. This article investigates how HIV-positive persons accessing care and treatment go about their everyday lives in the ART clinic and how they have eventually come to see the clinic as a safe place that they call 'home'...
December 2016: SAHARA J: Journal of Social Aspects of HIV/AIDS Research Alliance
Jessica A Ziegler, Robert G Bergman, John Arnold
Reaction of (BDI)Nb(N(t)Bu)Cl2py with NaCp results in the κ(1)-coordination of the BDI ligand in the complex (κ(1)-N,BDI)CpNb(N(t)Bu)Cl (2). Via chloride abstraction from 2, we develop synthetic routes to structurally analogous cationic and Nb(IV) pseudo-four coordinate complexes where the BDI ligand returns to the κ(2)-coordination mode. We compare these to our previously reported tetrahedral niobium bis(imido) complexes to investigate the effects of the Cp ligand on the properties of Nb-BDI-imido systems...
August 9, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Xianju Xie, Lin Wang, Dan Xing, Dwayne D Arola, Michael D Weir, Yuxing Bai, Hockin H K Xu
OBJECTIVES: We recently developed a new rechargeable composite with nanoparticles of amorphous calcium phosphate (NACP) having long-term calcium (Ca) and phosphate (P) ion release; however, this composite was not antibacterial. The objectives of this study were to: (1) incorporate dimethylaminohexadecyl methacrylate (DMAHDM) and 2-methacryloyloxyethyl phosphorylcholine (MPC) into rechargeable NACP composite, and (2) investigate mechanical properties, protein adsorption and biofilm response of composite, and the pH of biofilm medium...
September 2016: Journal of Dentistry
Lei Cheng, Ke Zhang, Chen-Chen Zhou, Michael D Weir, Xue-Dong Zhou, Hockin H K Xu
Dental composites are commonly used restorative materials; however, secondary caries due to biofilm acids remains a major problem. The objectives of this study were (1) to develop a composite containing quaternary ammonium dimethacrylate (QADM), nanoparticles of silver (NAg), and nanoparticles of amorphous calcium phosphate (NACP), and (2) to conduct the first investigation of the mechanical properties, biofilm response and acid production vs water-ageing time from 1 day to 12 months. A 4 × 5 design was utilized, with four composites (NACP-QADM composite, NACP-NAg composite, NACP-QADM-NAg composite, and a commercial control composite), and five water-ageing time periods (1 day, and 3, 6, 9, and 12 months)...
September 29, 2016: International Journal of Oral Science
David Bonekamp, Maya B Wolf, Christopher Edler, Sonja Katayama, Heinz-Peter Schlemmer, Klaus Herfarth, Matthias Röthke
PURPOSE: To characterize parametric changes measured by sequential dynamic contrast enhanced perfusion MRI (DCE-MRI) during primary proton and carbon ion irradiation of prostate cancer using a novel hypofractionated raster scan technique to determine the potential of pharmacokinetic analysis for monitoring treatment effects of this novel irradiation scheme. MATERIALS AND METHODS: Ninety-two patients were evaluated prospectively with DCE-MRI at baseline, day 10 during therapy, and 6weeks, 6months and 18months after treatment completion...
August 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Ning Zhang, Michael D Weir, Chen Chen, Mary A S Melo, Yuxing Bai, Hockin H K Xu
OBJECTIVES: White spot lesions often occur in orthodontic treatments. The objective of this study was to develop a novel resin-modified glass ionomer cement (RMGI) as an orthodontic cement with protein-repellent, antibacterial and remineralization capabilities. METHODS: Protein-repellent 2-methacryloyloxyethyl phosphorylcholine (MPC), antibacterial dimethylaminohexadecyl methacrylate (DMAHDM), nanoparticles of silver (NAg), and nanoparticles of amorphous calcium phosphate (NACP) were incorporated into a RMGI...
July 2016: Journal of Dentistry
Subash Chandra Sonkar, Kirti Wasnik, Anita Kumar, Pratima Mittal, Daman Saluja
BACKGROUND: Trichomoniasis, a sexually transmitted disease (STD), is caused by Trichomonas vaginalis in both men and women. Screening of trichomoniasis is problematic in resource challenged settings as currently available, inexpensive diagnostic methods are of low sensitivity and/or specificity. In India, National AIDS Control organization (NACO) recommended syndromic case management (SCM) for treatment. The objective of the present study was to compare the utility of the NACO-NACP III Algorithms for STI/RTI treatment used by clinicians with PCR based diagnosis...
May 5, 2016: Infectious Diseases of Poverty
C Matrosic, W Culberson, B Rosen, E Madsen, G Frank, B Bednarz
In vivo dosimetry is a greatly underutilized tool for patient safety in clinical external beam radiotherapy treatments, despite being recommended by several national and international organizations (AAPM, ICRU, IAEA, NACP). The reasons for this underutilization mostly relate to the feasibility and cost of in vivo dosimetry methods. Due to the increase in the number of beam angles and dose per fraction in modern treatments, there is a compelling need for a novel dosimeter that is robust and affordable while able to operate properly in these complex conditions...
May 21, 2016: Physics in Medicine and Biology
Mary Anne Melo, Santiago Orrego, Michael D Weir, Huakun H K Xu, Dwayne D Arola
The oral environment is considered to be an asperous environment for restored tooth structure. Recurrent dental caries is a common cause of failure of tooth-colored restorations. Bacterial acids, microleakage, and cyclic stresses can lead to deterioration of the polymeric resin-tooth bonded interface. Research on the incorporation of cutting-edge anticaries agents for the design of new, long-lasting, bioactive resin-based dental materials is demanding and provoking work. Released antibacterial agents such as silver nanoparticles (NAg), nonreleased antibacterial macromolecules (DMAHDM, dimethylaminohexadecyl methacrylate), and released acid neutralizer amorphous calcium phosphate nanoparticles (NACP) have shown potential as individual and dual anticaries approaches...
May 11, 2016: ACS Applied Materials & Interfaces
Rashmi Sharma, Pradeep Kumar, Brijesh Patel, Sanju Gajjar
INTRODUCTION: Second key strategy of National AIDS Control Program (NACP IV) is comprehensive care and support by providing quality services through zero stigma and discrimination. Quality of services can be improved by eliminating stigma and discrimination and making health care provider aware of associated occupational hazards. Nursing staff play crucial role and are more at risk therefore their understanding, perception and skill must be assessed in different domains of learning to improve the contents and methodology of trainings...
April 2016: Indian Journal of Community Medicine
Ke Zhang, Lei Cheng, Michael D Weir, Yu-Xing Bai, Hockin H K Xu
Composites containing nanoparticles of amorphous calcium phosphate (NACP) remineralize tooth lesions and inhibit caries. A recent study synthesized quaternary ammonium methacrylates (QAMs) with chain lengths (CLs) of 3-18 and determined their effects on a bonding agent. This study aimed to incorporate these QAMs into NACP nanocomposites for the first time to simultaneously endow the material with antibacterial and remineralizing capabilities and to investigate the effects of the CL on the mechanical and biofilm properties...
March 30, 2016: International Journal of Oral Science
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