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https://www.readbyqxmd.com/read/29656192/in-vitro-bioanalysis-of-drinking-water-from-source-to-tap
#1
Anna Kjerstine Rosenmai, Johan Lundqvist, Théo le Godec, Åsa Ohlsson, Rikard Tröger, Björn Hellman, Agneta Oskarsson
The presence of chemical pollutants in sources of drinking water is a key environmental problem threatening public health. Efficient removal of pollutants in drinking water treatment plants (DWTPs) is needed as well as methods for assessment of the total impact of all present chemicals on water quality. In the present study we have analyzed the bioactivity of water samples from source to tap, including effects of various water treatments in a DWTP, using a battery of cell-based bioassays, covering health-relevant endpoints...
April 6, 2018: Water Research
https://www.readbyqxmd.com/read/29655804/characterization-of-wdr20-a-new-regulator-of-the-erad-machinery
#2
Lin-Gao Ju, Xiang Lin, Dong Yan, Qing-Lan Li, Min Wu, Lian-Yun Li
ERAD is an important process of protein quality control that eliminates misfolded or unassembled proteins from ER. Before undergoing proteasome degradation, the misfolded proteins are dislocated from ER membrane into cytosol, which requires the AAA ATPase p97/VCP and its cofactor, the NPL4-UFD1 dimer. Here, we performed a CRISPR-based screen and identify many candidates for ERAD regulation. We further confirmed four proteins, FBOX2, TRIM6, UFL1 and WDR20, are novel regulators for ERAD. Then the molecular mechanism for WDR20 in ERAD is further characterized...
April 12, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29655692/effects-of-xin-ji-er-kang-on-heart-failure-induced-by-myocardial-infarction-role-of-inflammation-oxidative-stress-and-endothelial-dysfunction
#3
Juan Hu, Pan Cheng, Guang-Yao Huang, Guo-Wei Cai, Feng-Zhen Lian, Xiao-Yun Wang, Shan Gao
BACKGROUND: Xin-Ji-Er-Kang (XJEK) is a Chinese herbal formula, which has been reported to exert effective protection on cardiovascular diseases like hypertension and myocarditis. PURPOSE: To elucidate the protective effects of XJEK on heart failure (HF) induced by myocardial infarction (MI) through the amelioration of inflammation, oxidative stress (OS) and endothelial dysfunction(ED). MATERIALS AND METHODS: Fifty-seven male KM mice were randomized into the following six groups (n = 9-10 for each): control group, model group, MI+XJEK low dose group(XJEKL) group, MI+XJEK middle dose group(XJEKM), MI+XJEK high dose group(XJEKH), and MI+fosinopril group (positive control group)...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29655680/panduratin-a-induces-protective-autophagy-in-melanoma-via-the-ampk-and-mtor-pathway
#4
Siew-Li Lai, Mohd Rais Mustafa, Pooi-Fong Wong
BACKGROUND: Targeting autophagy is emerging as a promising strategy in cancer therapeutics in recent years. Autophagy can be modulated to drive cancer cell deaths that are notoriously resistant to apoptotic-inducing drugs. In addition, autophagy has been implicated as a prosurvival mechanism in mediating cancer chemoresistance. Our previous study has demonstrated that Panduratin A (PA), a plant-derived active compound exploits ER-stress-mediated apoptosis as its cytotoxic mechanism on melanoma...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29655652/protective-role-of-rosmarinic-acid-on-amyloid-beta-42-induced-echoic-memory-decline-implication-of-oxidative-stress-and-cholinergic-impairment
#5
Deniz Kantar Gok, Enis Hidisoglu, Guzide Ayse Ocak, Hakan Er, Alev Duygu Acun, Piraye Yargıcoglu
In the present study, we examined whether rosmarinic acid (RA) reverses amyloid β (Aβ) induced reductions in antioxidant defense, lipid peroxidation, cholinergic damage as well as the central auditory deficits. For this purpose, Wistar rats were randomly divided into four groups; Sham(S), Sham + RA (SR), Aβ42 peptide (Aβ) and Aβ42 peptide + RA (AβR) groups. Rat model of Alzheimer was established by bilateral injection of Aβ42 peptide (2,2 nmol/10 μl) into the lateral ventricles. RA (50 mg/kg, daily) was administered orally by gavage for 14 days after intracerebroventricular injection...
April 12, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29653438/the-effect-of-a-cricket-fielding-session-on-glenohumeral-range-of-motion-and-active-joint-position-sense
#6
Liam Newton, Steve McCaig
OBJECTIVE: To assess the effects of a cricket fielding session, at an identified throwing injury risk workload, on shoulder joint position sense (JPS) and active range of motion (AROM) in cricketers. DESIGN: Repeated measures observational study. SETTING: Indoor cricket centre. PARTICIPANTS: Nineteen, asymptomatic University cricketers. MAIN OUTCOME: AROM was assessed supine at 90° abduction and from this 10% off end range IR and ER was used as the position matching angle to assess JPS...
April 4, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29652570/shear-bond-strength-of-composite-and-ceromer-superstructures-to-direct-laser-sintered-and-ni-cr-based-infrastructures-treated-with-ktp-nd-yag-and-er-yag-lasers-an-experimental-study
#7
Oguzhan Gorler, Ihsan Hubbezoglu, Melih Ulgey, Recai Zan, Kubra Guner
OBJECTIVE: The aim of this study was to examine the shear bond strength (SBS) of ceromer and nanohybrid composite to direct laser sintered (DLS) Cr-Co and Ni-Cr-based metal infrastructures treated with erbium-doped yttrium aluminum garnet (Er:YAG), neodymium-doped yttrium aluminum garnet (Nd:YAG), and potassium titanyl phosphate (KTP) laser modalities in in vitro settings. METHODS: Experimental specimens had four sets (n = 32) including two DLS infrastructures with ceromer and nanohybrid composite superstructures and two Ni-Cr-based infrastructures with ceromer and nanohybrid composite superstructures...
April 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29652569/efficacy-of-various-pretreatments-on-the-bond-strength-of-denture-teeth-to-denture-base-resins
#8
Fatih Sari, Ozlem Ustun, Omer Kirmali
OBJECTIVE: This in vitro study evaluated the shear bond strength (SBS) of heat-cured denture base resin (PMMA) to acrylic resin teeth treated with different pretreatments, especially laser irradiation of different powers (1-4 W). MATERIALS AND METHODS: The acrylic resin teeth were separated into seven groups (n = 10) for the following different pretreatments: control group (no surface treatment) (G1), grinding with a tungsten carbide bur (G2), sandblasting (G3), and erbium, chromium: yttrium, scandium, gallium, garnet (Er,Cr:YSGG) laser irradiation at 1 W, 2 W, 3 W, 4 W output powers in (G4-7), respectively...
April 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29652358/high-precision-3d-surface-topography-measurement-using-high-stable-multi-wavelength-digital-holography-referenced-by-an-optical-frequency-comb
#9
Dahi Ghareab Abdelsalam Ibrahim, Takeshi Yasui
High-stable, two-wavelength, digital holography referenced by an optical frequency comb is presented. The technique is demonstrated by using optical waves from an external cavity laser diode phase-locked to a mode-locked Er-doped fiber comb laser light. The mixed beat signal is stabilized at 30 MHz by a sensitive proportional integral derivative controller. The tunable continuous-waves stabilized with frequency uncertainty of 5×10-11 are employed to investigate large stepped structures.
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29652350/continuous-wave-and-res-2-passively-q-switched-er-srf-2-laser-at-%C3%A2-3-%C3%AE-m
#10
Mingqi Fan, Tao Li, Jia Zhao, Shengzhi Zhao, Guiqiu Li, Kejian Yang, Liangbi Su, Houyi Ma, Christian Kränkel
We report on an efficient Er:SrF2 laser at 2.79 μm. A continuous wave output power of 1.06 W was obtained with a slope efficiency of 41%, significantly exceeding the Stokes efficiency of 35%. Stable Q-switched laser operation was realized by using an ReS2 saturable absorber, generating an average output power of 0.58 W with a pulse duration of 508 ns at a repetition rate of 49 kHz, corresponding to a pulse energy of 12.1 μJ.
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29652338/mid-infrared-frequency-comb-generation-via-cascaded-quadratic-nonlinearities-in-quasi-phase-matched-waveguides
#11
Abijith S Kowligy, Alex Lind, Daniel D Hickstein, David R Carlson, Henry Timmers, Nima Nader, Flavio C Cruz, Gabriel Ycas, Scott B Papp, Scott A Diddams
We experimentally demonstrate a simple configuration for mid-infrared (MIR) frequency comb generation in quasi-phase-matched lithium niobate waveguides using the cascaded-χ(2) nonlinearity. With nanojoule-scale pulses from an Er:fiber laser, we observe octave-spanning supercontinuum in the near-infrared with dispersive wave generation in the 2.5-3 μm region and intrapulse difference frequency generation in the 4-5 μm region. By engineering the quasi-phase-matched grating profiles, tunable, narrowband MIR and broadband MIR spectra are both observed in this geometry...
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29652329/940-mw-1564-nm-multi-longitudinal-mode-and-440-mw-1537-nm-single-longitudinal-mode-continuous-wave-er-yb-lu-2-si-2-o-7-microchip-lasers
#12
Jianhua Huang, Yujin Chen, Yanfu Lin, Xinghong Gong, Zundu Luo, Yidong Huang
An Er:Yb:Lu2 Si2 O7 microchip laser was constructed by placing a 1.2 mm thick, Y-cut Er:Yb:Lu2 Si2 O7 microchip between two 1.2 mm thick sapphire crystals, in which input and output mirrors were directly deposited onto one face of each crystal. End-pumped by a continuous-wave 975.4 nm diode laser, a 1564 nm multi-longitudinal-mode laser with a maximum output power of 940 mW and slope efficiency of 20% was realized at an absorbed pump power of 5.5 W when the transmission of output mirror was 2.2%. When the transmission of the output mirror was increased to 6%, a 1537 nm single-longitudinal-mode laser with a maximum output power of 440 mW and slope efficiency of 12% was realized at an absorbed pump power of 4...
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29652142/enantioselective-bioaccumulation-and-toxicity-of-the-neonicotinoid-insecticide-dinotefuran-in-the-earthworms-eisenia-fetida
#13
Tong Liu, Dan Chen, Yiqiang Li, Xiuguo Wang, Fenglong Wang
The enantioselective bioaccumulation and toxicity of dinotefuran in earthworms were studied in this study. The results showed that S-dinotefuran accumulated faster than Rac-dinotefuran and R-dinotefuran in earthworms. The acute toxicity of S-dinotefuran was 1.49 and 2.67 times that of the Rac-dinotefuran and R-dinotefuran in artificial soil during 14 d of exposure. At 1.0 mg/kg, the three tested chemicals inhibited the growth and reproduction as well as induced oxidative stress effects in earthworms; however, the toxic effects induced by S-dinotefuran were the most serious...
April 13, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29651764/can-functional-parameters-from-hepatobiliary-phase-of-gadoxetate-mri-predict-clinical-outcomes-in-patients-with-cirrhosis
#14
Kumar Sandrasegaran, Enming Cui, Reem Elkady, Pauley Gasparis, Gitasree Borthakur, Mark Tann, Suthat Liangpunsakul
OBJECTIVES: To determine the value of quantitative parameters of gadoxetate-enhanced magnetic resonance imaging (MRI) in predicting prognosis in patients with cirrhosis. METHODS: A cohort of 63 cirrhotic patients who had gadoxetate MRI and 2-year clinical follow-up was enrolled. Enhancement ratio (ER), contrast enhancement index (CEI) and contrast enhancement spleen index (CES) were calculated. The usefulness of these parameters and clinical scores, such as Child-Pugh score (CPS) and model for end stage liver disease (MELD), in predicting adverse outcomes, such as variceal bleeding (VB), hepatic encephalopathy (HE) and mortality at 2 years were evaluated...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29651385/clinicopathological-predictors-of-long-term-benefit-in-breast-cancer-treated-with-neoadjuvant-chemotherapy
#15
Marco Galvez, Carlos A Castaneda, Joselyn Sanchez, Miluska Castillo, Lia Pamela Rebaza, Gabriela Calderon, Miguel De La Cruz, Jose Manuel Cotrina, Julio Abugattas, Jorge Dunstan, Henry Guerra, Omar Mejia, Henry L Gomez
AIM: To investigate the survival impact of clinicopathological factors, including pathological complete response (pCR) and tumor-infiltrating lymphocytes (sTIL) levels according to subtypes, in breast cancer (BC) patients who received neo-adjuvant chemotherapy (NAC). METHODS: We evaluated 435 BC patients who presented and received NAC at the Instituto Nacional de Enfermedades Neoplasicas from 2003 to 2014. sTIL was analyzed as the proportion of tumor stroma occupied by lymphocytes, and was prospectively evaluated on hematoxylin and eosin-stained sections of the preNAC core biopsy...
April 10, 2018: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29650929/-a-case-of-her2-positive-occult-breast-cancer-presenting-as-swollen-axillary-lymphnodes
#16
Toshiyuki Ishiba, Goshi Oda, Tsuyoshi Nakagawa, Takumi Akashi, Yamato Yamashita, Tomoki Aburatani, Taichi Ogo, Yutaka Nakashima, Hironobu Baba, Naoaki Hoshino, Yoshinobu Nishioka, Tatsuyuki Kawano
Occult breast cancer, which develops as a metastatic lesion with no primary tumor detected in the breast, is a rare breast cancer. A 68-year-old female patient particularly complained of the presence of a right axillary mass. The mass in the right axilla was palpable, but no tumor was found in both the breasts on palpation, ultrasound examination, or MRI. Partial breast resection and axillary lymph node dissection were performed following a diagnosis of invasive ductal carcinoma by core needle biopsy. There was no mammary gland tissue present around the tumor due to the pathology of the disease, and the tumor was diagnosed as occult breast cancer...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650905/-a-case-of-her2-positive-breast-cancer-with-liver-metastases-showing-three-years-of-complete-response-to-combination-therapy-with-trastuzumabplus-pertuzumab
#17
Yuri Fujimoto, Kazushige Yamaguchi, Ayako Ueno, Reo Sakurai, Yoshio Nagahisa, Shiro Imai, Kazuyuki Kawamoto
A 48-year-old woman with severe interstitial pneumonitis was diagnosed with right breast cancer(invasive ductal carcinoma, T1aN1M0, ER+, PgR-, HER2 3+)and underwent modified radical mastectomy.The patient was administered tamoxifen as adjuvant therapy.However, 1 year after the mastectomy, multiple liver metastases were found and the patient received 2 anti-HER2 agents, trastuzumab and pertuzumab.A complete response(CR)was observed with the disappearance of the liver metastases in 7 months.CR was maintained for 2 years after the initiation of treatment, and then, we started trastuzumab monotherapy, which has resulted in long-term disease control...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650694/lymphatic-vasculature-requires-er-estrogen-receptor-%C3%AE-signaling-to-protect-from-lymphedema
#18
Florent Morfoisse, Florence Tatin, Benoit Chapût, Nicole Therville, Charlotte Vaysse, Raphael Métivier, Julie Malloizel-Delaunay, Francoise Pujol, Anne-Claire Godet, Fabienne De Toni, Frederic Boudou, Katia Grenier, David Dubuc, Eric Lacazette, Anne-Catherine Prats, Julie Guillermet-Guibert, Francoise Lenfant, Barbara Garmy-Susini
OBJECTIVE: Estrogens exert beneficial effect on the blood vascular system. However, their role on the lymphatic system has been poorly investigated. We studied the protective effect of the 17β estradiol-the most potent endogenous estrogen-in lymphedema-a lymphatic dysfunction, which results in a massive fluid and fat accumulation in the limb. APPROACH AND RESULTS: Screening of DNA motifs able to mobilize ERs (estrogen receptors) and quantitative real-time polymerase chain reaction analysis revealed that estradiol promotes transcriptional activation of lymphangiogenesis-related gene expression including VEGF (vascular endothelial growth factor)-D, VEGFR (VEGF receptor)-3, lyve-1, and HASs (hyaluronan synthases)...
April 12, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29650545/regulation-of-blood-pressure-by-targeting-ca-v-1-2-galectin-1-protein-interaction
#19
Zhenyu Hu, Guang Li, Jiong-Wei Wang, Suet Yen Chong, Dejie Yu, Xiaoyuan Wang, Jia Lin Soon, Mui Cheng Liang, Yuk Peng Wong, Na Huang, Henry M Colecraft, Ping Liao, Tuck Wah Soong
Background -L-type CaV 1.2 channels play crucial roles in regulation of blood pressure. Galectin-1 (Gal-1), has been reported to bind to the I-II loop of CaV 1.2 channels to reduce their current density. However, the mechanistic understanding for the down-regulation of CaV 1.2 channels by Gal-1, and whether Gal-1 plays a direct role in blood pressure regulation remain unclear. Methods - In vitro experiments involving co-IP, western blot, patch-clamp recordings, immunohistochemistry and pressure myography were used to evaluate the molecular mechanisms by which Gal-1 down-regulates CaV 1...
April 12, 2018: Circulation
https://www.readbyqxmd.com/read/29650257/neuropeptide-y-mitigates-er-stress-induced-neuronal-cell-death-by-activating-the-pi3k-xbp1-pathway
#20
Do Yeon Lee, Seung Hyun Hong, Bokyung Kim, Dong-Seok Lee, Kweon Yu, Kyu-Sun Lee
The unfolded protein response (UPR) is an evolutionarily conserved adaptive reaction that increases cell survival under endoplasmic reticulum (ER) stress conditions. ER stress-associated neuronal cell death pathways play roles in the pathogenesis of neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's disease. Neuropeptide Y (NPY) has an important role in neuroprotection against neurodegenerative diseases. In this study, we investigated whether NPY has a protective role in ER stress-induced neuronal cell death in SK-N-SH human neuroblastoma cells...
April 6, 2018: European Journal of Cell Biology
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