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https://www.readbyqxmd.com/read/29031054/magnetic-biochar-catalyst-derived-from-biological-sludge-and-ferric-sludge-using-hydrothermal-carbonization-preparation-characterization-and-its-circulation-in-fenton-process-for-dyeing-wastewater-treatment
#1
He Zhang, Gang Xue, Hong Chen, Xiang Li
To solve sludge disposal and management problems during dyeing wastewater treatment, the produced excess biological sludge and ferric sludge were fabricated into a magnetic biochar composite (MBC) under the optimal hydrothermal carbonization (HTC) conditions. With ferric sludge mixing, the generated MBC contained paramagnetic Fe3O4, showed a smaller diameter of approximately 200 nm, a smaller pore size, a larger specific surface area and a higher carbonization degree than BC prepared using a single biological sludge process under the same HTC conditions...
October 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/29027598/a-randomized-phase-ii-study-of-weekly-paclitaxel-with-or-without-pelareorep-in-patients-with-metastatic-breast-cancer-final-analysis-of-canadian-cancer-trials-group-ind-213
#2
V Bernstein, S L Ellard, S F Dent, D Tu, M Mates, S K Dhesy-Thind, L Panasci, K A Gelmon, M Salim, X Song, M Clemons, D Ksienski, S Verma, C Simmons, H Lui, K Chi, H Feilotter, L J Hagerman, L Seymour
BACKGROUND: Pelareorep, a serotype 3 reovirus, has demonstrated preclinical and early clinical activity in breast cancer and synergistic cytotoxic activity with microtubule targeting agents. This multicentre, randomized, phase II trial was undertaken to evaluate the efficacy and safety of adding pelareorep to paclitaxel for patients with metastatic breast cancer (mBC). METHODS: Following a safety run-in of 7 patients, 74 women with previously treated mBC were randomized either to paclitaxel 80 mg/m(2) intravenously on days 1, 8, and 15 every 4 weeks plus pelareorep 3 × 10(10) TCID50 intravenously on days 1, 2, 8, 9, 15, and 16 every 4 weeks (Arm A) or to paclitaxel alone (Arm B)...
October 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29026695/comparison-between-antibacterial-effect-of-chlorhexidine-0-2-and-different-concentrations-of-cyperus-rotundus-extract-an-in-vitro-study
#3
Roza Haghgoo, Majid Mehran, Hamideh Farajian Zadeh, Elaheh Afshari, Nafiseh Farajian Zadeh
AIMS AND OBJECTIVES: Modern methods of caries prevention concentrated on natural ingredients usage such as probiotics and polyphenols that are safer for young children with Streptococcus mutans inhibitory properties. The purpose of this study was to compare antibacterial effects of different concentration of Cyperus rotundus extract and chlorhexidine (CHX) 0.2% mouthwash on S. mutans and Lactobacillus acidophilus. MATERIALS AND METHODS: In this in vitro study, the antibacterial effectiveness of the C...
September 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29023413/diallylthiosulfinate-allicin-a-volatile-antimicrobial-from-garlic-allium-sativum-kills-human-lung-pathogenic-bacteria-including-mdr-strains-as-a-vapor
#4
Jana Reiter, Natalja Levina, Mark van der Linden, Martin Gruhlke, Christian Martin, Alan J Slusarenko
Garlic (Allium sativum) has potent antimicrobial activity due to allicin (diallylthiosulfinate) synthesized by enzyme catalysis in damaged garlic tissues. Allicin gives crushed garlic its characteristic odor and its volatility makes it potentially useful for combating lung infections. Allicin was synthesized (>98% pure) by oxidation of diallyl disulfide by H₂O₂ using formic acid as a catalyst and the growth inhibitory effect of allicin vapor and allicin in solution to clinical isolates of lung pathogenic bacteria from the genera Pseudomonas, Streptococcus, and Staphylococcus, including multi-drug resistant (MDR) strains, was demonstrated...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29022391/kr-12-a5-is-a-non-cytotoxic-agent-with-potent-antimicrobial-effects-against-oral-pathogens
#5
Karina Sampaio Caiaffa, Loiane Massunari, Marcelle Danelon, Gabriel Flores Abuna, Telma Blanca Lombardo Bedran, Norival Alves Santos-Filho, Denise Madalena Palomari Spolidorio, Natalia Leal Vizoto, Eduardo Maffud Cilli, Cristiane Duque
This study evaluated the cytotoxicity and antimicrobial activity of analogs of cationic peptides against microorganisms associated with endodontic infections. L-929 fibroblasts were exposed to LL-37, KR-12-a5 and hBD-3-1C(V) and chlorhexidine (CHX, control), and cell metabolism was evaluated with MTT. The minimal inhibitory concentration (MIC) and the minimal bactericidal/fungicidal concentration (MBC/MFC) of the peptides and CHX were determined against oral pathogens associated with endodontic infections. Enterococcus faecalis and Streptococcus mutans biofilms were cultivated in bovine dentin blocks, exposed to different concentrations of the most efficient antimicrobial peptide and analyzed by confocal laser scanning microscopy...
October 12, 2017: Biofouling
https://www.readbyqxmd.com/read/29021731/mbc-news
#6
(no author information available yet)
No abstract text is available yet for this article.
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28994740/antibacterial-and-antitubercular-activities-of-cinnamylideneacetophenones
#7
Carlos R Polaquini, Guilherme S Torrezan, Vanessa R Santos, Ana C Nazaré, Débora L Campos, Laíza A Almeida, Isabel C Silva, Henrique Ferreira, Fernando R Pavan, Cristiane Duque, Luis O Regasini
Cinnamaldehyde is a natural product with broad spectrum of antibacterial activity. In this work, it was used as a template for design and synthesis of a series of 17 cinnamylideneacetophenones. Phenolic compounds 3 and 4 exhibited MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) values of 77.9 to 312 µM against Staphylococcus aureus, Streptococcus mutans, and Streptococcus sanguinis. Compounds 2, 7, 10, and 18 presented potent effects against Mycobacterium tuberculosis (57...
October 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28994315/first-line-treatment-disruption-among-post-menopausal-women-with-hr-her2-metastatic-breast-cancer-a-retrospective-us-claims-study
#8
Derek H Tang, Nanxin Li, Ella X Du, Miranda Peeples, Lihao Chu, Jipan Xie, Victoria Barghout
OBJECTIVE: This study assessed disruption of first-line treatments initiated after the approval of the first CDK 4/6 inhibitor, palbociclib, among postmenopausal women with HR+/HER2- metastatic breast cancer (mBC) in the United States. METHODS: Postmenopausal women with HR+/HER2- mBC who initiated first-line endocrine therapy or chemotherapy (index therapy) between 3(rd) February 2015 (palbociclib approval date) and 29(th) February 2016 (end of data) were identified from the Symphony SourceLx database...
October 10, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28992479/bioaccumulation-of-uv-filters-in-mytilus-galloprovincialis-mussel
#9
Leticia Vidal-Liñán, Eugenia Villaverde-de-Sáa, Rosario Rodil, José Benito Quintana, Ricardo Beiras
In this study the bioaccumulation kinetics of organic UV filters, such as 4-MBC, BP-3, BP-4, OC and OD-PABA in wild Mytilus galloprovincialis mussels was investigated. The uptake and accumulation of waterborne 4-MBC, BP-4 and OC was very rapid, and after only 24 h of exposure to 1 μg L(-1), the tissular concentrations were 418, 263 and 327 μg kg(-1)d.w., respectively. The kinetics of bioaccumulation of BP-4 and OC significantly fitted to an asymptotic model with BCF values of 905 L kg(-1) and 2210 L kg(-1), respectively...
September 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/28988129/assessment-of-synergistic-antibacterial-activity-of-combined-biosurfactants-revealed-by-bacterial-cell-envelop-damage
#10
Santanu Sana, Sriparna Datta, Dipa Biswas, Dipanjan Sengupta
Besides potential surface activity and some beneficial physical properties, biosurfactants express antibacterial activity. Bacterial cell membrane disrupting ability of rhamnolipid produced by Pseudomonas aeruginosa C2 and a lipopeptide type biosurfactant, BS15 produced by Bacillus stratosphericus A15 was examined against Staphylococcus aureus ATCC 25923 and Escherichia coli K8813. Broth dilution technique was followed to examine minimum inhibitory concentration (MIC) of both the biosurfactants. The combined effect of rhamnolipid and BS15 against S...
October 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28982254/biotransformation-of-cubebin-by-aspergillus-spp-into-hinokinin-and-parabenzlactone-and-their-evaluation-against-oral-pathogenic-bacteria
#11
Caroline Arruda, Daniele de Souza Eugênio, Monique Rodrigues Moreira, Guilherme Venâncio Símaro, Jairo Kenupp Bastos, Carlos Henrique Gomes Martins, Márcio Luís Andrade Silva, Rodrigo Cássio Sola Veneziani, Paula Bruzadelle Vieira, Sérgio R Ambrósio
The biotransformation of the lignan (-)-cubebin by filamentous fungi Aspergillus terreus and Aspergillus niger is an efficient bioprocess for obtaining (-)-hinokinin and (-)-parabenzlactone. The relevance of getting (-)-hinokinin is due to its promising effect against oral pathogens, especially S. sanguinis (both MIC and MBC 12.5 μg/mL), and other previous reported effects against Chagas disease and as anti-inflammatory. The advantage of using fungal transformation is the use of non-toxic and/or non-pollutant reagents and/or solvents in comparison with semi-synthesis...
October 6, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28981332/foreword
#12
Claire Ryan, Russell Burcombe, Tracey Coleby
Delivering multifaceted, quality care to women living with metastatic breast cancer (MBC) demands professional competence and an advanced level of practice. The breast cancer nursing community is evolving to meet this need as more nurses are appointed specifically for the advanced disease setting, while nurses who previously worked only in early stage disease are now delivering care across the disease trajectory, fulfilling a 'diagnosis to death' nursing model. The MBC nursing community, linked by UK charity Breast Cancer Care and the Roche Nursing Matters programme, offers forums for learning, and provides ongoing support to this group of nurses...
September 5, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28981331/introduction
#13
Claire Ryan
Metastatic breast cancer (MBC), also known as secondary breast cancer (SBC), occurs when cells from the primary breast tumour metastasise from the breast to other parts of the body via the blood or lymphatic systems. The disease may range from limited bone metastases to widespread and life-threatening metastases in visceral organs such as the liver, lung and brain (National Institute for Health and Care Excellence (NICE), 2009; 2014). MBC is incurable, and the primary goal of treatment is to extend life and palliate symptoms, while preserving quality of life (NICE, 2009; 2014)...
September 5, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28978004/detection-of-esr1-mutations-in-circulating-cell-free-dna-from-patients-with-metastatic-breast-cancer-treated-with-palbociclib-and-letrozole
#14
Rekha Gyanchandani, Karthik J Kota, Amruth R Jonnalagadda, Tanya Minteer, Beth A Knapick, Steffi Oesterreich, Adam M Brufsky, Adrian V Lee, Shannon L Puhalla
ESR1 mutations are frequently acquired in hormone-resistant metastatic breast cancer (MBC). CDK4/6 inhibition along with endocrine therapy is a promising strategy in hormone receptor-positive MBC. However, the incidence and impact of ESR1 mutations on clinical outcome in patients treated with CDK4/6 inhibitors have not been defined. In this study, we evaluated the frequency of ESR1 mutations in cfDNA from 16 patients with MBC undergoing palbociclib and letrozole therapy. Four common ESR1 mutations (D538G, Y537C, Y537N, and Y537S) were analyzed in serial blood draws using ddPCR...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28975114/activation-of-phosphoinositide-3-kinase-akt-mechanistic-target-of-rapamycin-pathway-and-response-to-everolimus-in-endocrine-receptor-positive-metastatic-breast-cancer-a-retrospective-pilot-analysis-and-viewpoint
#15
Jyoti Bajpai, Anant Ramaswamy, Arun Chandrasekharan, Surya Mishra, Tanuja Shet, Sudeep Gupta, R A Badwe
INTRODUCTION: Biomarkers predictive of response to mechanistic target of rapamycin (mTOR) inhibitor, everolimus, in endocrine receptor (ER)-positive metastatic breast cancer (MBC) are a work in progress. We evaluated the feasibility of directly measuring mTOR activity and phosphatase and tensin homolog (PTEN) expression and correlating their expression with response and survival. MATERIALS AND METHODS: MBC patients who received everolimus with endocrine therapy (ET) after progression on an aromatase inhibitor and had adequate tissue preservation for estimation of mTOR activity and PTEN expression were selected for analysis from a prospectively maintained database...
July 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28974979/improvement-of-citral-antimicrobial-activity-by-incorporation-into-nanostructured-lipid-carriers-a-potential-application-in-food-stuffs-as-a-natural-preservative
#16
Manijeh Mokarizadeh, Hossein Samadi Kafil, Saeed Ghanbarzadeh, Ainaz Alizadeh, Hamed Hamishehkar
At the present time, utilization of essential oils in food preservation to prevent bacterial and fungal growth and improve shelf life and safety of the food products has notably gained increased interest. The aim of the present study was to improve the antimicrobial efficacy of citral as a natural preservative using nanostructured lipid carriers (NLCs). Formulations of NLCs were characterized using particle size analysis and scanning electron microscopy methods. Possible citral-carrier interaction and citral encapsulation efficiency percent (EE%) were assessed by Fourier transform infrared (FTIR) spectroscopy and gas chromatography techniques, respectively...
October 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28970140/microrna-675-promotes-glioma-cell-proliferation-and-motility-by-negatively-regulating-retinoblastoma-1
#17
Yungui Zheng, Xiaowen Lu, Liepeng Xu, Zhe Chen, Qinxi Li, Jun Yuan
Previous studies indicated that microRNA(miR)-675 and its precursor lncRNA H19 were both overexpressed in glioma tissues, and H19 might play an oncogenic role. To investigate the involvement of miR-675 in gliomas and its underlying mechanisms, we here collected candidate target genes of miR-675-5p from miRTarBase (http://mirtarbase.mbc.nctu.edu.tw/, Release 6.0), which contains the experimentally validated microRNA-target interactions. Then, regulatory effects of miR-675 on its target genes were validated using clinical samples and glioma cell lines...
September 29, 2017: Human Pathology
https://www.readbyqxmd.com/read/28969677/chemical-composition-anti-biofilm-activity-and-potential-cytotoxic-effect-on-cancer-cells-of-rosmarinus-officinalis-l-essential-oil-from-tunisia
#18
Marwa Jardak, Jihene Elloumi-Mseddi, Sami Aifa, Sami Mnif
BACKGROUND: Rosmarinus officinalis L. from Tunisia, popularly known as rosemary, is of a considerable importance for its medicinal uses and aromatic value. The aim of this study was to examine the chemical composition of Rosmarinus officinalis essential oil (ROEO) and to evaluate its antibiofilm activity on biofilm-forming bacterium and its anticancer activity on cancer cell lines. METHODS: The chemical composition of Rosmarinus officinalis essential oil (ROEO) was analyzed by GC-MS and its antibacterial activity was evaluated by micro-dilution method...
October 2, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28969261/metaplastic-carcinoma-breast-a-clinical-analysis-of-nine-cases
#19
Manashi Ghosh, A Muneer, Vinita Trivedi, Kaustav Mandal, Santosh Shubham
Metaplastic Breast Carcinoma (MBC) is a rare heterogeneous group of primary breast malignancies with different subgroups; exhibits a variety of histopathologic patterns and appears to be both epithelial and mesenchymal in origin. The ideal treatment for MBC remains unknown, due to its low incidence and pathological variability. Owing to its rarity, MBC has been treated as a variant of Invasive Duct Carcinoma (IDC). But it has poorer prognosis as compared to IDC. This is a case series to evaluate clinicopathologic characteristics and the multi-disciplinary treatment of nine MBC patients treated in a single institute...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28969087/efficacy-and-safety-of-t-dm1-in-the-common-practice-of-her2-advanced-breast-cancer-setting-a-multicenter-study
#20
Alessandra Fabi, Michelino De Laurentiis, Michele Caruso, Enrichetta Valle, Luca Moscetti, Daniele Santini, Katia Cannita, Luisa Carbognin, Mariangela Ciccarese, Rosalba Rossello, Grazia Arpino, Vita Leonardi, Filippo Montemurro, Nicla La Verde, Daniele Generali, Alberto Zambelli, Giuseppa Scandurra, Michelangelo Russillo, Ida Paris, Anna Maria D'Ottavio, Gianfranco Filippelli, Marianna Giampaglia, Simonetta Stani, Agnese Fabbri, Daniele Alesini, Daniela Cianniello, Diana Giannarelli, Francesco Cognetti
Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate approved for the treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive, metastatic breast cancer (mBC). The aim of this 'field-practice' study was to investigate the efficacy and safety of T-DM1, focusing on treatment line, previous lapatinib treatment and patterns of metastasis. Three hundred and three patients with HER2-positive mBC who received T-DM1 were identified by reviewing the medical records of 24 Italian Institutions...
September 8, 2017: Oncotarget
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