keyword
MENU ▼
Read by QxMD icon Read
search

mbc

keyword
https://www.readbyqxmd.com/read/29244528/phase-iii-randomized-study-of-dual-human-epidermal-growth-factor-receptor-2-her2-blockade-with-lapatinib-plus-trastuzumab-in-combination-with-an-aromatase-inhibitor-in-postmenopausal-women-with-her2-positive-hormone-receptor-positive-metastatic-breast-cancer
#1
Stephen R D Johnston, Roberto Hegg, Seock-Ah Im, In Hae Park, Olga Burdaeva, Galina Kurteva, Michael F Press, Sergei Tjulandin, Hiroji Iwata, Sergio D Simon, Sarah Kenny, Severine Sarp, Miguel A Izquierdo, Lisa S Williams, William J Gradishar
Purpose Human epidermal growth factor receptor 2 (HER2) targeting plus endocrine therapy (ET) improved clinical benefit in HER2-positive, hormone receptor (HR)-positive metastatic breast cancer (MBC) versus ET alone. Dual HER2 blockade enhances clinical benefit versus single HER2 blockade. The ALTERNATIVE study evaluated the efficacy and safety of dual HER2 blockade plus aromatase inhibitor (AI) in postmenopausal women with HER2-positive/HR-positive MBC who received prior ET and prior neo(adjuvant)/first-line trastuzumab (TRAS) plus chemotherapy...
December 15, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29243075/the-effect-of-aspirin-on-circulating-tumor-cells-in-metastatic-colorectal-and-breast-cancer-patients-a-phase-ii-trial-study
#2
L Yang, Z Lv, W Xia, W Zhang, Y Xin, H Yuan, Y Chen, X Hu, Y Lv, Q Xu, X Weng, C Ni
PURPOSE: Aspirin could reduce the risk of cancer metastasis. Circulating tumor cells (CTCs) are a key factor of cancer metastasis, but no evidence has revealed how aspirin affects CTCs and its epithelial-mesenchymal transition (EMT). Here, we conducted a clinical trial to investigate how aspirin affects CTCs in metastatic colorectal cancer (MCC) and breast cancer patients (MBC). METHODS: The trial is retrospective registered at clinicaltrials.gov (NCT02602938). The eligible patients are given 100 mg aspirin q...
December 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29242966/cyp1a1-genetic-polymorphism-is-a-promising-predictor-to-improve-chemotherapy-effects-in-patients-with-metastatic-breast-cancer-treated-with-docetaxel-plus-thiotepa-vs-docetaxel-plus-capecitabine
#3
Xinna Zhou, Guoliang Qiao, Xiaoli Wang, Qingkun Song, Michael A Morse, Amy Hobeika, William R Gwin, Jun Ren, H Kim Lyerly
PURPOSE: A prospective study was performed to compare the outcome for metastatic breast cancer (MBC) patients treated with docetaxel plus thiotepa (DT) or docetaxel plus capecitabine (DC), and to explore the value of CYP1A1*2C polymorphisms in predicting clinical efficacy of these chemotherapies. METHODS: MBC patients (n = 130) were randomized to treatment with DT (n = 65) or DC (n = 65). Response rate, disease control rate, progression-free and overall survival were monitored...
December 14, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29241769/antibacterial-activity-of-artemisia-asiatica-essential-oil-against-some-common-respiratory-infection-causing-bacterial-strains-and-its-mechanism-of-action-in-haemophilus-influenzae
#4
Chao Xu, Guo-Yan Li, Hua Zhang, Yu-Na Zu, Zhen-Hua Li, Jian-Li Chen
The main objective of the current study was to investigate the chemical composition of the essential oil of Artemisia asiatica together with investigating the antibacterial effects it exerts on several common respiratory infection causing bacteria including Haemophilus influenzae. Its mechanism of action was studied using various state-of-the-art assays like scanning electron microscopy, DNA, RNA and protein leakage assays, growth curve assays etc. The essential oil was extracted from the leaves of A. asiatica by supercritical CO2 fluid extraction technology...
December 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29241765/oliveria-decumbens-essential-oil-chemical-compositions-and-antimicrobial-activity-against-the-growth-of-some-clinical-and-standard-strains-causing-infection
#5
Behrooz Alizadeh Behbahani, Farideh Tabatabaei Yazdi, Alireza Vasiee, Seyed Ali Mortazavi
Oliveria decumbens as a valuable medicinal plant is extensively used in traditional medicine. clinical and standard strains causing infection resistance to antimicrobial agents, is one of the important problems in medicine. The aim of this study was to investigate the antibacterial activities and phytochemical analysis of Oliveria decumbens essential oil on the growth of some clinical and standard strains causing infection (Pseudomonas aerogenes, Escherichia coli, Streptococcus pyogenes and Staphylococcus epidermidis)...
December 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29239131/finasteride-treatment-and-male-breast-cancer-a-register-based-cohort-study-in-four-nordic-countries
#6
Mathias Meijer, Lau Caspar Thygesen, Anders Green, Martha Emneus, Klaus Brasso, Peter Iversen, Eero Pukkala, Kristian Bolin, Knut Stavem, Annette K Ersbøll
A potential link has been suggested between dispensed finasteride and increased risk of male breast cancer (MBC). Due to the rare occurrence of MBC, it remains to be established if such a relationship exists. The purpose of this study was to combine nationwide registers in four countries to assess the potential association between dispensed finasteride and MBC. A cohort of all males with dispensed finasteride in Denmark, Finland, Norway, and Sweden (1,365,088 person years) was followed up for up to 15 years for breast cancer, and compared to a cohort of males unexposed to finasteride...
December 13, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29237546/impact-of-disease-progression-on-health-related-quality-of-life-in-patients-with-metastatic-breast-cancer-in-the-praegnant-breast-cancer-registry
#7
Volkmar Müller, Naiba Nabieva, Lothar Häberle, Florin-Andrei Taran, Andreas D Hartkopf, Bernhard Volz, Friedrich Overkamp, Anna Lisa Brandl, Hans-Christian Kolberg, Peyman Hadji, Hans Tesch, Johannes Ettl, Michael P Lux, Diana Lüftner, Erik Belleville, Peter A Fasching, Wolfgang Janni, Matthias W Beckmann, Pauline Wimberger, Carsten Hielscher, Tanja N Fehm, Sara Y Brucker, Diethelm Wallwiener, Andreas Schneeweiss, Markus Wallwiener
OBJECTIVES: Improved progression-free survival is considered as treatment goal for patients with metastatic breast cancer (MBC) since it is assumed to delay or prevent deterioration of quality of life. Aim of our analysis was to examine the influence of disease progression on health-related quality of life (HRQoL). MATERIALS AND METHODS: The PRAEGNANT study comprises a real-life registry for patients with MBC. HRQoL was assessed with the EORTC-QLQ-C30 Version 3...
September 11, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29234247/pi3k-mtor-inhibitors-in-the-treatment-of-luminal-breast-cancer-why-when-and-to-whom
#8
REVIEW
Francesco Schettini, Giuseppe Buono, Meghana V Trivedi, Sabino De Placido, Grazia Arpino, Mario Giuliano
Estrogen receptor (ER) signaling represents the main driver of tumor growth and survival in luminal breast cancer (BC). Despite the efficacy of endocrine agents, many patients with luminal BC do not respond to endocrine therapy and many others develop endocrine resistance over time, due to the activation of escape pathways such as the PI3K/AKT/mTOR signaling. Several clinical trials have demonstrated the efficacy of mTOR and PI3K inhibitors in overcoming endocrine resistance in hormone receptor-positive human epidermal growth factor receptor 2 (HER2)-negative metastatic BC (MBC) patients...
October 2017: Breast Care
https://www.readbyqxmd.com/read/29228091/a-randomized-phase-ii-study-evaluating-different-maintenance-schedules-of-nab-paclitaxel-in-the-first-line-treatment-of-metastatic-breast-cancer-final-results-of-the-ibcsg-42-12-big-2-12-snap-trial
#9
A Gennari, Z Sun, U Hasler-Strub, M Colleoni, M J Kennedy, R Von Moos, J Cortés, M J Vidal, B Hennessy, J Walshe, K Amillano Parraga, K Ribi, J Bernhard, S Murillo Morales, O Pagani, A Barbeaux, S Borstnar, M Rabaglio-Poretti, R Maibach, M M Regan, G Jerusalem
Background: The phase II SNAP trial was designed to evaluate the efficacy of alternative chemotherapy schedules for prolonged administration in HER2-negative metastatic breast cancer (MBC), after a short induction at conventional doses. Methods: Between April 2013 and August 2015, 258 women untreated with chemotherapy for MBC were randomly assigned to receive three different maintenance chemotherapy schedules after three cycles of identical induction chemotherapy: Arm A, nab-Paclitaxel 150 mg/m2 days 1,15 Q28; Arm B, nab-Paclitaxel 100 mg/m2 days 1,8,15 Q28; Arm C, nab-Paclitaxel 75 mg/m2 days 1,8,15,22 Q28...
December 8, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29227905/antimicrobial-activity-of-gallic-acid-against-food-related-pseudomonas-strains-and-its-use-as-biocontrol-tool-to-improve-the-shelf-life-of-fresh-black-truffles
#10
Elena Sorrentino, Mariantonietta Succi, Luca Tipaldi, Gianfranco Pannella, Lucia Maiuro, Marina Sturchio, Raffaele Coppola, Patrizio Tremonte
Refrigeration alone or in combination with other technologies represents the main tool used in the last decades to preserve the freshness of black truffles. This is principally due to the delicateness and vulnerability of this edible hypogeous fungus, so that other invasive preservation practices cannot be adopted. However, the proliferation of some microbial species during the cold storage still represents an unsolved problem. Pseudomonads are among the main spoiler bacteria responsible for the deterioration of refrigerated black truffles...
December 2, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29221847/outpatient-pain-medication-use-an-electronic-daily-diary-study-in-metastatic-breast-cancer
#11
Ellen Stephenson, Anita DeLongis, Brian Bruel, Hoda Badr
CONTEXT: Understanding cancer patients' everyday pain experiences and their concomitant use of pain medication may help identify ways to improve pain management among outpatients. OBJECTIVES: This study examined the between-person and within-person associations between pain intensity and analgesic use in metastatic breast cancer (MBC) patients. METHODS: 53 women who were initiating treatment for MBC completed electronic diary assessments 6 times per day for 14 days...
December 5, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29214215/genomic-and-transcriptomic-heterogeneity-in-metaplastic-carcinomas-of-the-breast
#12
Salvatore Piscuoglio, Charlotte K Y Ng, Felipe C Geyer, Kathleen A Burke, Catherine F Cowell, Luciano G Martelotto, Rachael Natrajan, Tatiana Popova, Christopher A Maher, Raymond S Lim, Ino de Bruijn, Odette Mariani, Larry Norton, Anne Vincent-Salomon, Britta Weigelt, Jorge S Reis-Filho
Metaplastic breast cancer (MBC) is a rare special histologic type of triple-negative breast cancer, characterized by the presence of neoplastic cells showing differentiation towards squamous epithelium and/or mesenchymal elements. Here we sought to define whether histologically distinct subgroups of MBCs would be underpinned by distinct genomic and/or transcriptomic alterations. Microarray-based copy number profiling identified limited but significant differences between the distinct MBC subtypes studied here, despite the limited sample size (n = 17)...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29209624/in-vitro-antibacterial-activity-of-pomegranate-juice-and-peel-extracts-on-cariogenic-bacteria
#13
Gianmaria Fabrizio Ferrazzano, Elisa Scioscia, Daniela Sateriale, Gabiria Pastore, Roberta Colicchio, Chiara Pagliuca, Tiziana Cantile, Brunella Alcidi, Marco Coda, Aniello Ingenito, Elena Scaglione, Annunziata Gaetana Cicatiello, Maria Grazia Volpe, Michele Di Stasio, Paola Salvatore, Caterina Pagliarulo
Aim: To evaluate the antimicrobial activity of hydroalcoholic extracts of pomegranate (Punica granatum L.) peel and juice, against the microorganisms considered the main etiologic agents of dental caries. Methods: The values of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined against Streptococcus mutans Clarke ATCC® 25175™ strain and Rothia dentocariosa clinical isolate. Results: Peel extracts inhibit effectively the growth and survival of S...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29209529/patient-reported-pain-severity-pain-interference-and-health-status-in-hr-her2-advanced-metastatic-breast-cancer
#14
Robert Wood, Debanjali Mitra, Jonathan de Courcy, Shrividya Iyer
Introduction: Patient-reported pain severity and related impact in advanced/metastatic breast cancer (ABC/MBC) are not well documented. The objective of this study was to assess pain and general health status in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) ABC/MBC. Methods: Data were collected in the USA and Europe in a real-world, cross-sectional study. Patients were recruited at oncology practices and completed validated questionnaires; pain severity and interference were assessed using the Brief Pain Inventory (BPI) and general health status using the EuroQoL-5D (EQ-5D-3L)...
2017: ESMO Open
https://www.readbyqxmd.com/read/29209288/antimicrobial-effects-of-sulfonyl-derivative-of-2-5h-furanone-against-planktonic-and-biofilm-associated-methicillin-resistant-and-susceptible-staphylococcus-aureus
#15
Irshad S Sharafutdinov, Elena Y Trizna, Diana R Baidamshina, Maria N Ryzhikova, Regina R Sibgatullina, Alsu M Khabibrakhmanova, Liliya Z Latypova, Almira R Kurbangalieva, Elvira V Rozhina, Mareike Klinger-Strobel, Rawil F Fakhrullin, Mathias W Pletz, Mikhail I Bogachev, Airat R Kayumov, Oliwia Makarewicz
The gram-positive opportunistic bacterium Staphylococcus aureus is one of the most common causatives of a variety of diseases including skin and skin structure infection or nosocomial catheter-associated infections. The biofilm formation that is an important virulence factor of this microorganism renders the antibiotic therapy ineffective, because biofilm-embedded bacteria exhibit strongly increased tolerance to antimicrobials. Here, we describe a novel 3-chloro-5(S)-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4-[4-methylphenylsulfonyl]-2(5H)-furanone (F105), possessing a sulfonyl group and l-menthol moiety...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29209222/pk-pd-analysis-of-marbofloxacin-against-streptococcus-suis-in-pigs
#16
Zhixin Lei, Qianying Liu, Bing Yang, Haseeb Khaliq, Jiyue Cao, Qigai He
Marbofloxacin is a fluoroquinolone antibiotic and highly effective treatment for respiratory diseases. Here we aimed to evaluate the ex vivo activity of marbofloxacin against Streptococcus suis in pig serum, as well as the optimal dosages scheme for avoiding the fluoroquinolone resistance development. A single dose of 8 mg/kg body weight (bw) was administrated orally to healthy pigs and serum samples were collected during the next 72 h. Serum marbofloxacin content was determined by high-performance liquid chromatography...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29208540/phytochemical-analysis-and-antibacterial-activities-extracts-of-mangrove-leaf-against-the-growth-of-some-pathogenic-bacteria
#17
Behrooz Alizadeh Behbahani, Farideh Tabatabaei Yazdi, Fakhri Shahidi, Hamid Noorbakhsh, Alireza Vasiee, Ali Alghooneh
In this study, the effects of water, ethanol, methanol and glycerin at five levels (0, 31.25, 83.33, 125 and 250 ml) were investigated on the efficiency of mangrove leaf extraction using mixture optimal design. The antimicrobial effect of the extracts on Streptococcus pneumoniae, Enterococcus faecium and Klebsiella pneumoniae was evaluated using disk diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) methods. The mangrove leaf extraction components were identified through gas chromatography/mass spectrometry (GC/MS)...
December 2, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29206142/composition-and-antibacterial-activity-of-the-essential-oils-of-orthosiphon-stamineus-benth-and-ficus-deltoidea-jack-against-pathogenic-oral-bacteria
#18
Nuramirah Azizan, Shahida Mohd Said, Zamirah Zainal Abidin, Ibrahim Jantan
In this study, the essential oils of Orthosiphon stamineus Benth and Ficus deltoidea Jack were evaluated for their antibacterial activity against invasive oral pathogens, namely Enterococcus faecalis, Streptococcus mutans, Streptococcus mitis, Streptococcus salivarius, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Fusobacterium nucleatum. Chemical composition of the oils was analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The antibacterial activity of the oils and their major constituents were investigated using the broth microdilution method (minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC))...
December 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29204896/a-comparison-of-tumour-size-measurements-with-palpation-ultrasound-and-mammography-in-male-breast-cancer-first-results-of-the-prospective-register-study
#19
Martin Streng, Atanas Ignatov, Mattea Reinisch, Serban-Dan Costa, Holm Eggemann
PURPOSE: Precise presurgical diagnosis of tumour size is essential for adequate treatment of male breast cancer (MBC). This study is aimed to compare the accuracy of clinical measurement (CE), ultrasound (US) and mammography (MG) for preoperative estimation of tumour size. METHODS: This study was conducted as a prospective, multicentre register study. One hundred and twenty-nine male patients with invasive breast cancer were included. CE, US and MG were performed in 107, 110 and 75 patients, respectively, and the estimated tumour size was compared with the histopathological (HP) tumour size...
December 4, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29203365/antibacterial-activities-phytochemical-analysis-and-chemical-composition-makhlaseh-extracts-against-the-growth-of-some-pathogenic-strain-causing-poisoning-and-infection
#20
Behrooz Alizadeh Behbahani, Abbas Ali Imani Fooladi
The aim of this study was to investigate the antibacterial activities and phytochemical analysis of extracts against the growth of some pathogenic strain causing poisoning and infection (Staphylococcus aureus, Streptococcus pyogenes, Staphylococcus epidermidis, Enterobacter aerogenes, Escherichia coli and Shigella flexneri). Makhlaseh components were identified via gas chromatography/mass spectrometry (GC/MS). Total phenolic content (TPC), alkaloids, tannins and saponins were determined. Antioxidant activity was determined calorimetrically for 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity...
December 1, 2017: Microbial Pathogenesis
keyword
keyword
93970
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"