keyword
https://read.qxmd.com/read/38436182/age-and-dual-trigger-were-found-to-be-significant-predictors-of-live-birth-in-poseidon-group-3-and-4-women-treated-with-the-gnrh-antagonist-protocol-a-retrospective-cohort-study
#21
JOURNAL ARTICLE
B Varlı, Y E Sukur, B Ozmen, M Sönmezer, C Atabekoğlu, R Aytaç, B Berker
OBJECTIVE: Despite recent advancements in assisted reproductive technology (ART), the effective management of patients with poor ovarian response (POR) remains a formidable challenge. While various treatment strategies and predictors of live births have been documented to provide guidance to fertility specialists in managing poor responders, research efforts have predominantly encompassed all POSEIDON groups. In this study, our objective was to analyze the factors correlated with live births (LB) within a subset of the POSEIDON groups, with a particular focus on POSEIDON groups 3 and 4...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38435758/oral-gnrh-antagonists-in-combination-with-estradiol-and-norethindrone-acetate-for-pain-relief-associated-with-endometriosis-a-review-of-evidence-of-a-novel-class-of-hormonal-agents
#22
REVIEW
Essam R Othman, Ayman Al-Hendy, Radwa Mostafa, Cornelis B Lambalk, Velja Mijatovic
Current medical treatment options for endometriosis associated pains are inadequate. Evidence on effects of nonsteroidal anti-inflammatory drugs is scarce. Around one third of patients are not responsive to oral contraceptives or progestins due to progesterone resistance. Gonadotropin-releasing hormone (GnRH) agonists can only be used for a short duration because of associated side effects. Oral GnRH antagonists, including elagolix, relugolix, and linzagolix allow oral administration, induce dose dependent reduction of estradiol levels, do not cause initial flare up of endometriosis symptoms, and allow the fast return of ovarian function and menstruation after discontinuation...
2024: International Journal of Women's Health
https://read.qxmd.com/read/38434132/prediction-of-placenta-previa-from-serial-reading-of-serum-human-chorionic-gonadotropin-late-in-the-first-half-of-pregnancy
#23
JOURNAL ARTICLE
Shatha Sami Hussein, Manal Madany A Qader, Wisam Akram
BACKGROUND: Abnormally sited placenta is considered a major life-threatening condition for pregnant woman, and many debate about the way of early diagnosis and management to decrease the mortality and morbidity. AIM OF STUDY: To evaluate the role of beta-human chorionic gonadotrophin (B-HCG) level in the first half of pregnancy as a marker for prediction of placenta previa. STUDY DESIGN: This is a prospective study done in Al-Yarmouk Teaching Hospital from first of January 2020 till first of January 2021...
February 2024: Journal of Obstetrics and Gynaecology of India
https://read.qxmd.com/read/38433710/mechanisms-of-probiotic-modulation-of-ovarian-sex-hormone-production-and-metabolism-a-review
#24
REVIEW
Xiao Liu, Xiaoyong Chen, Chen Wang, Jiajia Song, Jiahui Xu, Zhen Gao, Yechuan Huang, Huayi Suo
Sex hormones play a pivotal role in the growth and development of the skeletal, neurological, and reproductive systems. In women, the dysregulation of sex hormones can result in various health complications such as acne, hirsutism, and irregular menstruation. One of the most prevalent diseases associated with excess androgens is polycystic ovary syndrome with a hyperandrogenic phenotype. Probiotics have shown the potential to enhance the secretion of ovarian sex hormones. However, the underlying mechanism of action remains unclear...
March 4, 2024: Food & Function
https://read.qxmd.com/read/38422116/hormonebayes-a-novel-bayesian-framework-for-the-analysis-of-pulsatile-hormone-dynamics
#25
JOURNAL ARTICLE
Margaritis Voliotis, Ali Abbara, Julia K Prague, Johannes D Veldhuis, Waljit S Dhillo, Krasimira Tsaneva-Atanasova
The hypothalamus is the central regulator of reproductive hormone secretion. Pulsatile secretion of gonadotropin releasing hormone (GnRH) is fundamental to physiological stimulation of the pituitary gland to release luteinizing hormone (LH) and follicle stimulating hormone (FSH). Furthermore, GnRH pulsatility is altered in common reproductive disorders such as polycystic ovary syndrome (PCOS) and hypothalamic amenorrhea (HA). LH is measured routinely in clinical practice using an automated chemiluminescent immunoassay method and is the gold standard surrogate marker of GnRH...
February 29, 2024: PLoS Computational Biology
https://read.qxmd.com/read/38421423/comparison-of-progesterone-protocol-versus-gonadotropin-releasing-hormone-antagonist-protocol-in-terms-of-preventing-premature-lh-surge-and-assisted-reproductive-technology-outcome-in-infertile-women-a-randomized-controlled-trial
#26
JOURNAL ARTICLE
Masoome Jabarpour, Sara Pouri, Ashraf Aleyasin, Maryam Shabani Nashtaei, Aida Najafian
INTRODUCTION: Progesterone can be used instead of GnRH agonists and antagonists in order to avert a premature LH surge during controlled ovarian stimulation (COS) protocol. Nonetheless, there is limited knowledge regarding its utilization. Thus, this study compared the effects of progesterone and GnRH antagonists (GnRH-ant) on premature LH surges and assisted reproductive technology (ART) results in infertile women undergoing ART. MATERIALS AND METHODS: In this clinical trial, the progesterone protocol (study group) and GnRH-ant protocol (control group) were tested in 300 infertile individuals undergoing IVF/ICSI...
February 29, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38412750/perimenopausal-abnormal-uterine-bleeding
#27
REVIEW
Eva Dreisler, Christian Seerup Frandsen, Lian Ulrich
Abnormal uterine bleeding is a frequent symptom in the perimenopause. Causes are numerous, ranging from physiological reactions due to decreasing/unstable ovarian function to premalignant and malignant conditions. Benign findings such as endometrial polyps and myomas increase with age, leading to more abnormal uterine bleeding in the perimenopause. Cervical and vaginal causes of abnormal uterine bleeding should be excluded by speculum examination. Sexually transmitted diseases or pregnancy should be ruled out...
February 22, 2024: Maturitas
https://read.qxmd.com/read/38410698/effects-of-different-gonadotropin-preparations-in-gnrh-antagonist-protocol-for-patients-with-polycystic-ovary-syndrome-during-ivf-icsi-a-retrospective-cohort-study
#28
JOURNAL ARTICLE
Zhengyan Hu, Rujun Zeng, Rui Gao, Mingli Chen, Xiumei Liu, Qiong Zhang, Lang Qin, Xun Zeng
PURPOSE: To compare the effects of recombinant FSH alfa (rFSH-alfa), rFSH-beta, highly purified human menopausal gonadotropin (HP-hMG) and urinary FSH (uFSH) in women with polycystic ovarian syndrome who have undertaken the GnRH antagonist protocol during IVF/ICSI treatment. METHOD: A single-center retrospective cohort study including women with PCOS who received the GnRH antagonist protocol from January 2019 to July 2022 was conducted. Patients were divided into rFSH-alfa group, HP-hMG group, uFSH group, and rFSH-beta group, and the number of oocytes retrieved, clinical pregnancy rate of the fresh cycle (primary outcomes), embryo quality, and severe OHSS rate (secondary outcomes) were compared...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38400669/fertility-counselling-and-fertility-preservation-among-early-onset-female-cancer-patients-a-finnish-register-based-study
#29
JOURNAL ARTICLE
Johanna Melin, Elina Holopainen, Hanna Savolainen-Peltonen
INTRODUCTION: Advances in multimodality cancer treatments have increased long-term survival rates for early onset cancer patients, with 5-year survival rates reaching 80% in Northern Europe. According to recent recommendations, clinicians should, as early as possible, inform cancer patients about the impact that cancer treatment may have on their fertility. Still, there is limited published data on fertility counselling (FC) and fertility preservation (FP) for cancer patients. METHODS: This register-based study used hospital records to identify female cancer patients in the hospital district (n = 192) who received FC at the age of 16-42 years between 2011 and 2019...
February 2024: Cancer Medicine
https://read.qxmd.com/read/38396659/current-insights-in-prolactin-signaling-and-ovulatory-function
#30
REVIEW
Dariusz Szukiewicz
Prolactin (PRL) is a pleiotropic hormone released from lactotrophic cells of the anterior pituitary gland that also originates from extrapituitary sources and plays an important role in regulating lactation in mammals, as well as other actions. Acting in an endocrine and paracrine/autocrine manner, PRL regulates the hypothalamic-pituitary-ovarian axis, thus influencing the maturation of ovarian follicles and ovulation. This review provides a detailed discussion of the current knowledge on the role of PRL in the context of ovulation and ovulatory disorders, particularly with regard to hyperprolactinemia, which is one of the most common causes of infertility in women...
February 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38393358/-premenstrual-syndrome-and-premenstrual-dysphoric-disorder-overview-on-pathophysiology-diagnostics-and-treatment
#31
REVIEW
Jana Haußmann, M Goeckenjan, R Haußmann, P Wimberger
Premenstrual syndrome and premenstrual dysphoric disorder become episodically manifest during the second half of the female menstrual cycle and are characterized by psychological and physical symptoms causing relevant functional and social impairments. Mood swings, depression and dysphoria are associated depressive symptoms. Therefore, affective disorders should be considered as a differential diagnosis. Of women in reproductive age 3-8% suffer from premenstrual syndrome and 2% of women are affected by premenstrual dysphoric disorder...
February 23, 2024: Der Nervenarzt
https://read.qxmd.com/read/38391397/ovarian-stimulation-for-in-vitro-fertilization-and-reproductive-outcome-after-surgical-treatment-of-endometriosis-compared-with-tubal-factor-infertility
#32
JOURNAL ARTICLE
Elena-Silvia Nadă, Cătălin Bogdan Coroleucă, Ciprian Andrei Coroleucă, Elvira Brătilă
Endometriosis is a common cause of infertility among reproductive-age women. A low ovarian reserve is associated with the presence of endometriotic cysts, and this is accentuated even more after surgery. Patients with a history of endometrioma are a special category of poor ovarian reserve requiring in vitro fertilization (IVF). The aim of this retrospective study was to evaluate the characteristics and outcome of ovarian stimulation and embryo transfer in women with a history of ovarian surgery for endometrioma compared with a control group with tubal factor infertility...
December 20, 2023: Clinics and Practice
https://read.qxmd.com/read/38388636/prevalence-and-impact-of-fertility-concerns-in-young-women-with-breast-cancer
#33
JOURNAL ARTICLE
Samantha Mannion, Alexandra Higgins, Nicole Larson, Elizabeth A Stewart, Zaraq Khan, Chandra Shenoy, Hazel B Nichols, H Irene Su, Ann H Partridge, Charles L Loprinzi, Fergus Couch, Janet E Olson, Kathryn J Ruddy
Survey data from the Mayo Clinic Breast Disease Registry were used to assess fertility counseling and fertility preservation strategies in a modern cohort of young women with breast cancer. One hundred respondents were identified who were under age 50 at the time of breast cancer diagnosis and who expressed interest in future childbearing near the time of diagnosis and/or 1 year later. Ninety-three percent of the 81 respondents to the year one survey recalled fertility counseling prior to cancer treatment. Most who reported a high level of fertility concern declared that this concern had impacted their treatment decisions, often shortening their planned duration of endocrine therapy...
February 22, 2024: Scientific Reports
https://read.qxmd.com/read/38382167/risk-of-borderline-ovarian-tumors-after-fertility-treatment-results-from-a-danish-cohort-of-infertile-women
#34
JOURNAL ARTICLE
Anna Kjær Kristensen, Clarissa Lima Brown Frandsen, Bugge Nøhr, Jakob Hansen Viuff, Marie Hargreave, Kirsten Frederiksen, Susanne K Kjær, Allan Jensen
OBJECTIVE: Results from previous studies examining the association between fertility treatment and borderline ovarian tumors are inconsistent. The aim of this study was to investigate the association between fertility treatment and borderline ovarian tumors in a cohort of infertile women. METHODS: This cohort study was based on the Danish Infertility Cohort and included all infertile women aged 20-45 years living in Denmark between 1 January 1995 and 31 December 2017 (n = 146,891)...
February 20, 2024: Gynecologic Oncology
https://read.qxmd.com/read/38375197/optimal-timing-of-gnrh-antagonist-initiation-in-ivf-et-a-retrospective-cohort-study-on-advanced-maternal-age-women
#35
JOURNAL ARTICLE
Qiao-Song Han, Yue Zhou, Ying Xu, Kai-Liang Ai, Jing-Yan Song, Zhen-Gao Sun
BACKGROUND: Several studies have compared the effects of fixed and flexible gonadotropin releasing hormone antagonist (GnRH-ant) protocols during in vitro fertilization and embryo transfer (IVF-ET). However, which GnRH-ant initiation strategy is better remains controversial. Moreover, no studies have assessed the optimal timing of GnRH-ant initiation in women of advanced maternal age (AMA). METHODS: In this retrospective cohort study, a total of 472 infertile women aged ≥ 35 years old undergoing their first IVF cycle from August 2015 to September 2021 at a tertiary academic medical center were recruited, of whom 136 followed fixed GnRH-ant protocol and 336 followed flexible GnRH-ant protocol...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38370492/does-body-mass-index-compromise-assisted-reproductive-technique-outcomes-a-cross-sectional-study
#36
JOURNAL ARTICLE
Fereshteh Bahrami, Saeideh Dashti, Esmat Mangoli, Hanie Sadat Hosseini
BACKGROUND: Overweight and obese people face several health problems. Female obesity has been shown to reduce fertility in the general population. Assisted reproductive technology outcomes in obese cases are widely studied, but the results are inconclusive. OBJECTIVE: This study aimed to compare live birth rate (LBR) among women with 4 different types of body mass index (BMI). MATERIALS AND METHODS: In this cross-sectional study, data of 1611 women, who were candidates for fresh and frozen embryo transfer cycles, was extracted from 2051 medical files at the Reproductive Sciences Institute, Yazd, Iran from May 2019-May 2021...
December 2023: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://read.qxmd.com/read/38368514/association-between-myometrial-thickness-and-assisted-reproductive-technologies-outcomes-a-prospective-cohort-study
#37
JOURNAL ARTICLE
Tahereh Madani, Nadia Jahangiri, Seyedeh Masoumeh Moosavisadat, Elaheh Mirzaagha, Saman Maroufizadeh, Shohreh Irani, Firoozeh Ahmadi
BACKGROUND: Myometrial thickness has been expected to be a prognosticator for lower uterine segment function. An abnormal function of the uterine muscle layer can cause common and important reproductive problems. This study aimed to evaluate the relationship between baseline myometrial thickness and assisted reproductive technologies (ART) outcomes. MATERIALS AND METHODS: In this prospective cohort study, 453 infertile women undergoing ART cycles without any obvious uterine pathology, participated in this prospective cohort study from February 2013 to May 2015...
February 2, 2024: International Journal of Fertility & Sterility
https://read.qxmd.com/read/38368513/association-of-follicular-fluid-antioxidants-activity-with-aging-and-in-vitro-fertilization-outcome-a-cross-sectional-study
#38
JOURNAL ARTICLE
Mahsa Afrough, Roshan Nikbakht, Mahmoud Hashemitabar, Elham Ghalambaz, Sareh Amirzadeh, Adel Zardkaf, Sahar Adham, Maryam Mehdipour, Parvin Dorfeshan
BACKGROUND: This research was aimed at assessing the relationship between the follicular fluid (FF) antioxidants activity, aging and in vitro fertilization (IVF) outcome. MATERIALS AND METHODS: The present cross-sectional study was carried out on 65 women undergoing IVF/intracytoplasmic sperm injection (IVF/ICSI) cycles due to unexplained infertility. Ovarian stimulation was performed using the long gonadotropin-releasing hormone (GnRH) agonist protocol. After ovum pickup, FF was collected and processed to measure the level of superoxide dismutase (SOD), catalase (CAT) activity, total antioxidant capacity (TAC) and glutathione (GSH)...
February 2, 2024: International Journal of Fertility & Sterility
https://read.qxmd.com/read/38358433/significance-of-serum-amh-and-antral-follicle-count-discrepancy-for-the-prediction-of-ovarian-stimulation-response-in-poseidon-criteria-patients
#39
JOURNAL ARTICLE
Alyssa Hochberg, Michael H Dahan, Hakan Yarali, Lan N Vuong, Sandro C Esteves
PURPOSE: To determine the risk of not being a poor responder in ovarian stimulation (OS) for in vitro fertilization (IVF) when ovarian reserve markers are discordant-one falling within Poseidon's criteria normal range (e.g., anti-Müllerian hormone (AMH) ≥ 1.2 ng/mL or antral follicle count (AFC) ≥ 5), and the other in the poor ovarian reserve range. METHODS: A tri-center retrospective cohort study (2015-2017) involving women with discordant AMH and AFC values undergoing their first IVF/ICSI cycle using conventional OS (cOS, ≥ 150 IU/day of follicle-stimulating hormone)...
February 15, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38357937/cumulative-live-birth-rate-of-in%C3%A2-vitro-fertilization-cycle-via-progestin-primed-ovarian-stimulation-versus-gonadotropin-releasing-hormone-antagonist-protocol-in-infertile-women-with-normal-ovarian-reserve-an-open-label-randomized-controlled-trial
#40
JOURNAL ARTICLE
Hongjuan Ye, Liya Shi, Xinxin Quan, Min Hou, Huilan Ma, Songguo Xue, Zhao Yu, Qiuju Chen, Lihua Sun
This study aimed to evaluate the cumulative live birth rate (cLBR) of progestin-primed ovarian stimulation (PPOS) protocol versus gonadotropin-releasing hormone antagonist (GnRH-ant) protocol for in vitro fertilization (IVF) cycle in infertile women with normal ovarian reserve (NOR). Infertile women with NOR who underwent their first IVF cycle were enrolled in an open-label randomized controlled trial. Patients were randomly assigned 1:1 to receive a freeze-all strategy with delayed embryo transfer (PPOS group, n = 174) and fresh embryo transfer first (GnRH-ant group, n = 174)...
December 2024: Human Fertility: Journal of the British Fertility Society
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