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Gonadotropin in women

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https://www.readbyqxmd.com/read/29218679/possibility-of-women-treated-with-fertility-sparing-surgery-for-non-epithelial-ovarian-tumors-to-safely-and-successfully-become-pregnant-a-chinese-retrospective-cohort-study-among-148-cases
#1
Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li
This study was performed to evaluate the oncological and reproductive outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000 and August 31, 2015 from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overall survival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P = 0...
December 7, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29216361/gnrh-receptor-antagonist-mono-and-combination-therapy-with-e2-neta-add-back-pharmacodynamics-and-safety-of-obe2109
#2
Oliver Pohl, Line Marchand, Neil Fawkes, Jean-Pierre Gotteland, Ernest Loumaye
Context: OBE2109 is a novel, potent, oral gonadotropin-releasing hormone receptor antagonist being developed for the treatment of sex-hormone-dependent diseases in women. Objective: We assessed the pharmacodynamics and safety of OBE2109 alone and combined with estradiol(E2)/norethindrone acetate(NETA) add-back therapy on E2 levels and vaginal bleeding. Design, Setting, and Participants: This was a single-center, open-label, randomized, parallel-group study in 76 healthy premenopausal women with regular menstrual cycles...
December 4, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29214643/trends-in-serum-human-chorionic-gonadotropin-levels-0-4-days-after-methotrexate-administration-for-predicting-tubal-ectopic-pregnancy-treatment-success
#3
Lo Wong, Linda W Y Fung, Chun-Wai Cheung, Terence T Lao
OBJECTIVE: To evaluate serum human chorionic gonadotropin (HCG) levels 0-4 days after single-dose methotrexate administration for tubal ectopic pregnancy. METHODS: The present retrospective study included women with tubal ectopic pregnancy treated by methotrexate at a tertiary hospital in Hong Kong, China, between January 1, 2007, and December 31, 2016. Patients were stratified serum HCG levels rose or fell from day 0-4 post-administration. Trends in day 0-4 serum HCG to predict treatment success were compared with that of day 4-7 serum HCG...
December 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29214637/identification-and-treatment-of-gestational-trophoblastic-neoplasia-located-in-the-cesarean-scar
#4
Xiaoyu Wang, Yuan Li, Junjun Yang, Yonglan He, Ming Wang, Xirun Wan, Yang Xiang
OBJECTIVE: To identify the clinical characteristics of, and the diagnostic and therapeutic strategies for, gestational trophoblastic neoplasia (GTN) located in the cesarean scar. METHODS: The present retrospective analysis was conducted among patients diagnosed with GTN located in the cesarean scar at Peking Union Medical College Hospital, Beijing, China, between June 1, 2006, and May 31, 2016. Clinical features, diagnostic and therapeutic procedures, and outcomes were reviewed...
December 6, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29212429/the-impact-of-luteinizing-hormone-supplementation-in-gonadotropin-releasing-hormone-antagonist-cycles-a-retrospective-cohort-study
#5
Wen He, Hui Lin, Jie Lv, Yanfei Wen, Liuhong Cai
The impact of exogenous luteinizing hormone (LH) supplementation to patients undergoing controlled ovarian stimulation with gonadotropin-releasing hormone (GnRH) antagonists on cycle outcomes is controversial. Here, we present a retrospective cohort study including cycles from December 2015 to December 2016. Totally 320 cycles were divided into two groups according to with or without exogenous LH supplementation. No significant differences regarding the number of retrieved oocytes, the number of good-quality embryos, and clinical pregnancy rate between the two groups were found...
December 6, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29209484/correlation-between-saliva-and-serum-concentrations-of-estradiol-in-women-undergoing-ovarian-hyperstimulation-with-gonadotropins-for-ivf-icsi
#6
C Dielen, T Fiers, S Somers, E Deschepper, J Gerris
Aim of the study: To examine saliva- and serum concentrations correlation of estradiol (E2) in women undergoing ovarian hyperstimulation for IVF/ICSI. Saliva measurements could simplify stimulation follow up. A 'home' test for E2 could be useful. Methods: Prospective interventional academic monocentric study at the Centre for Reproductive Medicine of the University Hospital of Ghent, Belgium. Between November 2014 and August 2015 thirty-one patients were included after random selection (inclusion criteria: < 41 years of age, any rank of IVF/ICSI cycle, serum anti- Müllerian hormone concentration ≥ 1 μg/L, treatment completely at the University Hospital...
June 2017: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/29207696/correlation-of-pregnancy-associated-plasma-protein-a-and-zinc-with-calculated-risk-ratio-of-dual-test
#7
Indranil Ghoshal, Bolar Suryakanth Varashree, Vijetha Shenoy Belle, Krishnananda Prabhu
Introduction: First trimester screening by dual test is the most preferred method of antenatal screening. The detection rate of foetal aneuploidy using dual test is 95%. This test uses maternal serum free β human Chorionic Gonadotropin (free β hCG) and Pregnancy Associated Plasma Protein A (PAPP-A) along with maternal demographic and foetal sonographic indices to calculate risk for foetal aneuploidy. PAPP-A is a zinc binding metalloproteinase which is also responsible for placental development and foetal growth...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206944/the-direct-and-indirect-effects-of-kisspeptin-54-on-granulosa-lutein-cell-function
#8
L A Owens, A Abbara, A Lerner, S O'floinn, G Christopoulos, S Khanjani, R Islam, K Hardy, A C Hanyaloglu, S A Lavery, W S Dhillo, S Franks
STUDY QUESTION: What are the in vivo and in vitro actions of kisspeptin-54 on the expression of genes involved in ovarian reproductive function, steroidogenesis and ovarian hyperstimulation syndrome (OHSS) in granulosa lutein (GL) cells when compared with traditional triggers of oocyte maturation? SUMMARY ANSWER: The use of kisspeptin-54 as an oocyte maturation trigger augmented expression of genes involved in ovarian steroidogenesis in human GL cells including, FSH receptor (FSHR), LH/hCG receptor (LHCGR), steroid acute regulatory protein (STAR), aromatase, estrogen receptors alpha and beta (ESR1, ESR2), 3-beta-hydroxysteroid dehydrogenase type 2 (3BHSD2) and inhibin A (INHBA), when compared to traditional maturation triggers, but did not alter markers of OHSS...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29198759/lowered-reference-limits-for-hcg-improve-follow-up-of-patients-with-hcg-producing-tumors
#9
Ragnhild V Nome, TTrine Bjøro, Elisabeth Paus, Johan Bjerner, Sophie D Fosså, Rita Steen, Kjell Nustad, Nils Bolstad
BACKGROUND: Human Chorionic Gonadotropin (hCG) is produced by germ cell tumors, but can also be elevated in benign conditions such as primary hypogonadism, where hCG is produced by the pituitary gland. In our experience, the reference limits for hCG (Elecsys hCG+β-assay, Roche Diagnostics), were unnecessarily high and did not reflect levels encountered in clinical practice. We wanted to establish new reference limits to increase the clinical utility of the hCG-assay. METHODS: We analysed hCG in serum samples from a healthy adult population and in a cohort of testicular cancer survivors...
November 30, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29197087/vaginal-discharge-concentrations-of-%C3%AE-human-chorionic-gonadotropin-creatinine-and-urea-for-the-diagnosis-of-premature-rupture-of-membranes
#10
Zinatossadat Bouzari, Roza Shahhosseini, Meadeh Mohammadnetaj, Shahnaz Barat, Shahla Yazdani, Karimollah Hajian-Tilaki
OBJECTIVE: To determine the diagnostic value of vaginal discharge concentrations of β human chorionic gonadotropin (β-hCG), creatinine, and urea to identify premature rupture of membranes (PROM). METHODS: An observational cross-sectional study was conducted between 12 June, 2014, and 11 June, 2015, among 120 women who were admitted to an Iranian hospital at 28-41 weeks of pregnancy. Women with positive pooling and nitrazine test results were assigned to the PROM group (n=60), whereas those with negative test results were assigned to the control group (n=60)...
December 2, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29186429/extracellular-matrix-in-uterine-leiomyoma-pathogenesis-a-potential-target-for-future-therapeutics
#11
Md Soriful Islam, Andrea Ciavattini, Felice Petraglia, Mario Castellucci, Pasquapina Ciarmela
BACKGROUND: Uterine leiomyoma (also known as fibroid or myoma) is the most common benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can produce serious clinical symptoms, including excessive uterine bleeding, pelvic pain or pressure, infertility and pregnancy complications. Due to lack of effective medical treatments surgery has been a definitive choice for the management of this tumor. OBJECTIVE AND RATIONALE: Extracellular matrix (ECM) accumulation and remodeling are thought to be crucial for fibrotic diseases such as uterine leiomyoma...
November 23, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29185361/melatonin-concentration-in-follicular-fluid-is-correlated-with-antral-follicle-count-afc-and-in-vitro-fertilization-ivf-outcomes-in-women-undergoing-assisted-reproductive-technology-art-procedures
#12
Min Zheng, Jing Tong, Wei-Ping Li, Zi-Jiang Chen, Cong Zhang
The aim of the present study was to evaluate the possible relationship between melatonin levels in the follicular fluid (FF) and in vitro fertilization (IVF) outcomes in women undergoing assisted reproductive treatment. Sixty-three females (20 to 40 years old) scheduled for IVF were divided into three groups based on their antral follicle count (AFC). We determined FF melatonin concentrations in group A (AFC≦6, n = 21), group B (7≦AFC≦14, n = 22), group C (AFC≧15, n = 20) on oocyte retrieval day...
November 29, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29184865/etiological-evaluation-of-repeated-biochemical-pregnancy-in-infertile-couples-who-have-undergone-in-vitro-fertilization
#13
Hyun-Mi Lee, Hwa Jeong Lee, Kwang Moon Yang, Sun Hwa Cha, Hyun Kyong Ahn, Young Joo Kim
Objective: This study aims to investigate whether there are any notable etiologies for repeated biochemical pregnancy (RBP) and, if so, to compare those etiologies associated with repeated spontaneous abortion in infertile couples who have undergone in vitro fertilization (IVF). Methods: Forty-four infertile couples who underwent IVF and experienced RBP were included in this study. RBP was defined as more than 2 early pregnancy losses that occurred before the detection of a gestational sac, with ectopic pregnancies specifically excluded by serial serum beta human chorionic gonadotropin evaluation...
November 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29181162/assessing-predictors-for-the-success-of-gnrh-antagonist-protocol-in-reproductive-women-in-ivf-icsi-in-fresh-cycles
#14
An-Cong Wang, Ying Wang, Feng-Xia Wu, Dong-Yi Zhu
The aim of the present study was to evaluate the factors that affect the success rate of gonadotropin-releasing hormone antagonist on in vitro fertilization/intracytoplasmic sperm injection cycles. Multivariate analysis was performed to assess the factors that influence the outcomes, such as oocytes retrieved, and the success of pregnancy. The results showed that E2, P on human chorionic gonadotropin (HCG) day and body mass index (BMI) were positively correlated with the number of oocytes retrieved (P=0.001, P=0...
November 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29179885/bilaterality-of-ovarian-endometriomas-does-not-affect-the-outcome-of-in%C3%A2-vitro-fertilization-intracytoplasmic-sperm-injection-in-infertile-women-after-laparoscopic-cystectomy
#15
Hsing-Tse Yu, Hong-Yuan Huang, Hsiao-Jung Tseng, Chin-Jung Wang, Chyi-Long Lee, Yung-Kuei Soong
BACKGROUND: To assess whether the unilateral or bilateral lesions can affect ovarian reserve and pregnancy outcome in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in infertility patients underwent laparoscopic cystectomy. METHODS: A total of 148 IVF/ICSI cycle in patients who had undergone laparoscopic cystectomy for unilateral or bilateral endometriomas were reviewed retrospectively. There were 103 cycles where laparoscopic cystectomy had been carried out for unilateral endometriomas and 45 cycles after bilateral-side surgery...
October 2017: Biomedical Journal
https://www.readbyqxmd.com/read/29177442/increased-27-hydroxycholesterol-production-during-luteolysis-may-mediate-the-progressive-decline-in-progesterone-secretion
#16
Yafei Xu, Scot M Hutchison, José J Hernández-Ledezma, Randy L Bogan
STUDY QUESTION: Does 27-hydroxycholesterol (27OH) actively facilitate the progression of luteolysis? SUMMARY ANSWER: There is increased mRNA expression of the enzyme that produces 27OH during luteolysis in vivo in rhesus macaques and sheep, and 27OH reduces progesterone secretion from human luteinized granulosa cells. WHAT IS KNOWN ALREADY: There is an increase in mRNA expression of liver x receptor (LXR) and a decrease in sterol regulatory element binding protein 2 (SREBP2) target genes during spontaneous luteolysis in primates, which could result in reduced cholesterol availability for steroidogenesis...
November 21, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29177245/controlled-ovarian-stimulation-with-r-fsh-plus-r-lh-vs-hmg-plus-r-fsh-in-patients-candidate-for-ivf-icsi-cycles-an-rct
#17
Ensieh Shahrokh Tehraninejad, Mina Farshbaf Taghinejad, Batool Hossein Rashidi, Fedyeh Haghollahi
Background: Different combination of gonadotropin preparation has been introduced with no definite superiority of one over others in in vitro fertilization (IVF), but individualized regimens for each patient are needed. Objective: The aim of the present study was to investigate the effect of controlled ovarian stimulation with recombinant- follicle stimulating hormone (r-FSH) plus recombinant-luteinizing hormone (rLH) versus human menopausal gonadotropin (HMG) plus r-FSH on fertility outcomes in IVF patients...
July 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29177244/final-follicular-maturation-by-administration-of-gnrh-agonist-plus-hcg-versus-hcg-in-normal-responders-in-art-cycles-an-rct
#18
Maryam Eftekhar, Maryam Farid Mojtahedi, Sepideh Miraj, Malihe Omid
Background: Gonadotropin-releasing hormone agonists (GnRH-a) was increasingly used for triggering oocyte maturationfor the prevention of ovarian hyperstimulation syndrome. Studies suggest that GnRH-a might be used as a better trigger agent since it causes both Luteinizing hormone and follicle stimulating hormone release from a physiologic natural cycle. Objective: The aim of this study was to evaluate the effect of dual-triggering in assisted reproductive technology outcomes...
July 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29177238/comparing-the-effect-of-gonadotropin-releasing-hormone-agonist-and-human-chorionic-gonadotropin-on-final-oocytes-for-ovulation-triggering-among-infertile-women-undergoing-intrauterine-insemination-an-rct
#19
Robabeh Taheripanah, Marzieh Zamaniyan, Atefeh Moridi, Anahita Taheripanah, Narges Malih
Background: The purpose of triggering in ovulation induction is to induce the final maturation of oocytes and their release from the ovary for fertilization. Objective: The aim of the present study was to compare the effectiveness of gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (HCG) on the final maturation of oocytes and pregnancy rates in intrauterine insemination (IUI) cycles. Materials and Methods: In this randomized clinical trial, 110 infertile women who were selected for IUI entered the study...
June 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29175067/quality-of-life-and-psychosocial-and-physical-well-being-among-1-023-women-during-their-first-assisted-reproductive-technology-treatment-secondary-outcome-to-a-randomized-controlled-trial-comparing-gonadotropin-releasing-hormone-gnrh-antagonist-and-gnrh-agonist
#20
Mette Toftager, Randi Sylvest, Lone Schmidt, Jeanette Bogstad, Kristine Løssl, Lisbeth Prætorius, Anne Zedeler, Thue Bryndorf, Anja Pinborg
OBJECTIVE: To compare self-reported quality of life, psychosocial well-being, and physical well-being during assisted reproductive technology (ART) treatment in 1,023 women allocated to either a short GnRH antagonist or long GnRH agonist protocol. DESIGN: Secondary outcome of a prospective phase 4, open-label, randomized controlled trial. Four times during treatment a questionnaire on self-reported physical well-being was completed. Further, a questionnaire on self-reported quality of life and psychosocial well-being was completed at the day of hCG testing...
November 23, 2017: Fertility and Sterility
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