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Gonadotropin in women

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https://www.readbyqxmd.com/read/29675930/relationship-between-ultrasonographic-and-biochemical-markers-of-tubal-ectopic-pregnancy-and-success-of-subsequent-management
#1
Batool Nadim, Chuan Lu, Fernando Infante, Shannon Reid, George Condous
OBJECTIVES: To determine whether there is an association between morphologic types of tubal ectopic pregnancy (EP), 0-hour human chorionic gonadotropin (hCG) levels, and subsequent management success. METHODS: We conducted a prospective study (November 2006-December 2015). Women had a diagnosis of EP by transvaginal ultrasonography if they had an inhomogeneous mass adjacent to the ovary and moving separately from it ("blob" sign), a mass with a hyperechoic ring around the gestational sac ("bagel" sign), or a gestational sac with an embryonic pole with or without a yolk sac with or without cardiac activity...
April 20, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29675488/trans-dermal-estrogen-oestrogel-for-endometrial-preparation-in-freeze-embryo-transfer-cycle-an-rct
#2
Ensieh Shahrokh Tehraninejad, Roya Kabodmehri, Batol Hosein Rashidi, Mina Jafarabadi, Fateme Keikha, Masomeh Masomi, Fedieh Hagholahi
Background: Estrogen and progesterone are two crucial factors for endometrial preparation in frozen embryo transfer (FET) cycles. Studies assessing different forms of estradiol in FET have published already but literature lacks enough surveys on transdermal estrogen application in reproductive medicine. Objective: To investigate the effects of trans dermal estrogen (Oestrogel) on pregnancy rates in patients that candidate for FET cycle. Materials and Methods: In this randomized clinical trial, 100 women undergoing FET cycles referred to Imam Khomeeini Hospital were enrolled in two groups, randomly...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29675483/fresh-versus-frozen-embryo-transfer-after-gonadotropin-releasing-hormone-agonist-trigger-in-gonadotropin-releasing-hormone-antagonist-cycles-among-high-responder-women-a-randomized-multi-center-study
#3
Abbas Aflatoonian, Mahnaz Mansoori-Torshizi, Maryam Farid Mojtahedi, Behrouz Aflatoonian, Mohammaad Ali Khalili, Mohammad Hossein Amir-Arjmand, Mehrdad Soleimani, Nastaran Aflatoonian, Homa Oskouian, Nasim Tabibnejad, Peter Humaidan
Background: The use of embryo cryopreservation excludes the possible detrimental effects of ovarian stimulation on the endometrium, and higher reproductive outcomes following this policy have been reported. Moreover, gonadotropin-releasing hormone agonist trigger in gonadotropin-releasing hormone (GnRH) antagonist cycles as a substitute for standard human chorionic gonadotropin trigger, minimizes the risk of ovarian hyperstimulation syndrome (OHSS) in fresh as well as frozen embryo transfer cycles (FET)...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29670770/genetic-variants-associated-with-hyperandrogenemia-in-pcos-pathophysiology
#4
REVIEW
Roshan Dadachanji, Nuzhat Shaikh, Srabani Mukherjee
Polycystic ovary syndrome is a multifactorial endocrine disorder whose pathophysiology baffles many researchers till today. This syndrome is typically characterized by anovulatory cycles and infertility, altered gonadotropin levels, obesity, and bulky multifollicular ovaries on ultrasound. Hyperandrogenism and insulin resistance are hallmark features of its complex pathophysiology. Hyperandrogenemia is a salient feature of PCOS and a major contributor to cosmetic anomalies including hirsutism, acne, and male pattern alopecia in affected women...
2018: Genetics Research International
https://www.readbyqxmd.com/read/29668890/luteinizing-hormone-facilitates-antral-follicular-maturation-and-survival-via-thecal-paracrine-signaling-in-cattle
#5
Katsushige Hattori, Makoto Orisaka, Shin Fukuda, Kimihisa Tajima, Yukiko Yamazaki, Tetsuya Mizutani, Yoshio Yoshida
The use of LH supplementation in assisted reproductive technology (ART) cycles improves the ongoing pregnancy rate in women with poor ovarian response (POR). However, our knowledge of the precise role of LH during the follicular phase of the menstrual cycle is incomplete. To explore the role of LH in the maturation of small antral follicles, we used an in vitro two-cell system that involved co-culturing bovine granulosa cells (GC) and theca cells (TC) on a collagen membrane. Treatment of TC with LH stimulated androgen production in TC by inducing the expression of androgenic factors, subsequently increasing estrogen biosynthesis in GC by providing androgen substrates and inducing aromatase expression...
April 13, 2018: Endocrinology
https://www.readbyqxmd.com/read/29668580/metastatic-epithelioid-trophoblastic-tumor-of-the-lung-a-case-report
#6
Wangjun Lei, Fangbiao Zhang, Chunhui Zheng, Chun Zhao, Shaosong Tu, Yingwei Bao
RATIONALE: Epithelioid trophoblastic tumor (ETT) is a very rare form of gestational trophoblastic disease (GTD) which arises from neoplastic proliferation of intermediate trophoblasts. Metastatic ETT of the lung is extremely rare in postmenopausal women. PATIENT CONCERNS: Here we describe a 50-year-old woman with a metastatic ETT of the lung showing increasing tracer uptake at PET/CT. DIAGNOSIS: Hematoxylin-eosin staining showed a tumor composed of nests of epithelioid cells with necrotic debris and peritumoral hyaline-like material...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29662710/natural-cycle-versus-artificial-cycle-in-frozen-thawed-embryo-transfer-a-randomized-prospective-trial
#7
Marzieh Agha-Hosseini, Leila Hashemi, Ashraf Aleyasin, Marzieh Ghasemi, Fatemeh Sarvi, Maryam Shabani Nashtaei, Mahshad Khodarahmian
Objective: To investigate whether there was a difference in pregnancy outcomes between modified natural cycle frozen-thawed embryo transfer (NC-FET) cycles and artificial cycles (AC)-FET in women who all had regular menstrual cycles. Materials and Methods: One hundred seventy patients who met the inclusion criteria and had at least two cryopreserved embryos were included in a prospective randomized controlled trial. Eighty-five patients were randomized based on Bernoulli distribution into the following two groups: 1) Modified NC-FET using human chorionic gonadotropin for ovulation induction and 2) AC-FET, in which endometrial timing was programmed with estrogen and progesterone...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29658438/a-systematic-review-of-first-trimester-biochemical-and-molecular-predictive-tests-for-preeclampsia
#8
Fatemeh Abdi, Zohreh Aghaie, Fatemeh Sadat Rahnemaie, Zainab Alimoradi
BACKGROUND: Preeclampsia is a multisystem disorder affecting 5%-8% of pregnant women. Considering the ongoing debate over the predicting value of some commercial first trimester tests, the aim of this study was to compare the existing first trimester screening tests for preeclampsia. METHODS: In this systematic review, relevant articles published during 2000-2017 were extracted from PubMed, Science Direct, Scopus, Cochrane Library, ISI Web of Science, and ProQuest databases...
April 16, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29648638/ovulatory-induction-of-scg2-in-human-non-human-primate-and-rodent-granulosa-cells-stimulates-ovarian-angiogenesis
#9
Patrick R Hannon, Diane M Duffy, Katherine L Rosewell, Mats Brännström, James W Akin, Thomas E Curry
The luteinizing hormone (LH) surge is essential for ovulation, but the intrafollicular factors induced by LH that mediate ovulatory processes (e.g. angiogenesis) are poorly understood, especially in women. The role of secretogranin II (SCG2) and its cleaved bioactive peptide, secretoneurin (SN), were investigated as potential novel mediators of ovulation by testing the hypothesis that SCG2/SN is induced in granulosa cells by human chorionic gonadotropin (hCG), via a downstream LH receptor signaling mechanism, and stimulates ovarian angiogenesis...
April 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/29648476/does-the-type-of-gnrh-analogue-used-affect-live-birth-rates-in-women-with-endometriosis-undergoing-ivf-icsi-treatment-according-to-the-rafs-stage
#10
Panagiotis Drakopoulos, Jérôme Rosetti, Nicola Pluchino, Christophe Blockeel, Samuel Santos-Ribeiro, Michael de Brucker, Petros Drakakis, Michel Camus, Herman Tournaye, Nikolaos P Polyzos
Since the introduction of gonadotropin-releasing hormone (GnRH) antagonists, an extensive amount of literature investigating the role of the downregulation protocols on pregnancy outcomes has been published. However, these studies were mainly performed in the general infertile population where patients with endometriosis were often excluded or underrepresented. This study is a large retrospective cohort study including 386 endometriosis patients undergoing IVF/ICSI, who had been previously classified according to the rAFS system...
April 12, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29644764/effect-of-simultaneously-started-clomiphene-citrate-and-gonadotropins-in-antagonist-regimes-on-cumulative-live-births-fresh-cycle-live-births-and-cost-of-stimulation-in-ivf-cycles
#11
Ruma Satwik, Mohinder Kochhar
AIM: The aim of the study was to compare simultaneously started clomiphene citrate (CC) and gonadotropins (Gn) with gonadotropins alone in conventional antagonist regimes with respect to fresh-cycle live births, cumulative live births and cost of ovarian stimulation per started cycle. METHODS: This was a single-center prospective cohort study conducted over 1 year. Women undergoing autologous in vitro fertilization (IVF) treatment in antagonist protocols and who consented to participate in the study were divided into two cohorts...
April 11, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29642911/gnrh-dysregulation-in-polycystic-ovarian-syndrome-pcos-is-a-manifestation-of-an-altered-neurotransmitter-profile
#12
Nirja Chaudhari, Mitali Dawalbhakta, Laxmipriya Nampoothiri
BACKGROUND: GnRH is the master molecule of reproduction that is influenced by several intrinsic and extrinsic factors such as neurotransmitters and neuropeptides. Any alteration in these regulatory loops may result in reproductive-endocrine dysfunction such as the polycystic ovarian syndrome (PCOS). Although low dopaminergic tone has been associated with PCOS, the role of neurotransmitters in PCOS remains unknown. The present study was therefore aimed at understanding the status of GnRH regulatory neurotransmitters to decipher the neuroendocrine pathology in PCOS...
April 11, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29642747/elevated-maternal-serum-free-%C3%AE-human-chorionic-gonadotropin-%C3%AE-hcg-and-reduced-risk-of-spontaneous-preterm-delivery
#13
Shelly Soni, David A Krantz, Matthew J Blitz, Nidhi Vohra, Burton Rochelson
OBJECTIVE: To evaluate the relationship between first and second trimester maternal serum-free β-hCG and the risk of spontaneous preterm delivery (PTD). STUDY DESIGN: This was a case-control study of women evaluated and delivered at our institution from 2011 to 2015. Spontaneous PTD was defined as delivery before 37 weeks due to spontaneous preterm labor or premature rupture of membranes. Patient with multifetal gestation and those with medically indicated term or PTD were excluded...
April 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29626233/the-effect-of-intrauterine-human-chorionic-gonadotropin-flushing-on-live-birth-rate-after-vitrified-warmed-embryo-transfer-in-programmed-cycles-a-randomized-clinical-trial
#14
Maryam Hafezi, Tahereh Madani, Arezoo Arabipoor, Zahra Zolfaghari, Marya Sadeghi, Fariba Ramezanali
PURPOSE: To assess the influence of intrauterine human chorionic gonadotropin (hCG) before embryo transfer on the clinical pregnancy and live birth rates after vitrified-warmed embryo transfer (ET) in programmed cycles. METHODS: This study was a single-blind randomized clinical trial for eligible patients underwent frozen ET cycles with long-term hormonal GnRH agonist protocol for endometrial preparation. Immediately prior to ET, the women were randomly divided into three groups...
April 6, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29621723/persistent-organic-pollutants-as-predictors-of-increased-fsh-lh-ratio-in-naturally-cycling-reproductive-age-women
#15
Mia V Gallo, Julia Ravenscroft, David O Carpenter, Lawrence M Schell, Akwesasne Task Force On The Environment
Although several recent studies suggest endocrine disrupting compounds, such as polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (p,p', DDE), and hexachlorobenzene (HCB), target different organs and systems in the body, their impact on female reproductive function in humans is not well characterized. We seek to determine the relationship between several known endocrine disrupting compounds and a marker of ovarian responsivity, the FSH:LH ratio (higher ratio indicates less ovarian responsivity)...
April 2, 2018: Environmental Research
https://www.readbyqxmd.com/read/29618656/ontogeny-and-reversal-of-brain-circuit-abnormalities-in-a-preclinical-model-of-pcos
#16
Mauro Sb Silva, Melanie Prescott, Rebecca E Campbell
Androgen excess is a hallmark of polycystic ovary syndrome (PCOS), a prevalent yet poorly understood endocrine disorder. Evidence from women and preclinical animal models suggests that elevated perinatal androgens can elicit PCOS onset in adulthood, implying androgen actions in both PCOS ontogeny and adult pathophysiology. Prenatally androgenized (PNA) mice exhibit a robust increase of progesterone-sensitive GABAergic inputs to gonadotropin-releasing hormone (GnRH) neurons implicated in the pathogenesis of PCOS...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29617818/fshb-211-g-t-is-a-major-genetic-modulator-of-reproductive-physiology-and-health-in-childbearing-age-women
#17
Kristiina Rull, Marina Grigorova, Aivar Ehrenberg, Pille Vaas, Aire Sekavin, Diana Nõmmemees, Mart Adler, Ele Hanson, Peeter Juhanson, Maris Laan
STUDY QUESTION: Are the genetic variants FSHB -211 G>T (rs10835638), FSHR c.2039 A>G (Asn680Ser, rs6166) and FSHR -29 G>A (rs1394205) associated with serum FSH, LH and anti-Müllerian hormone (AMH) levels in reproductive age women, their menstrual cycle parameters and risk of infertility? SUMMARY ANSWER: Only the FSHB -211 G>T variant was a major genetic determinant of serum gonadotropin levels in both, eumenorrheic healthy women and female infertility patients, and the T-allele carrier status was enriched among idiopathic infertility cases...
March 30, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29610265/preconception-blood-pressure-levels-and-reproductive-outcomes-in-a-prospective-cohort-of-women-attempting-pregnancy
#18
Carrie J Nobles, Pauline Mendola, Sunni L Mumford, Ashley I Naimi, Edwina H Yeung, Keewan Kim, Hyojun Park, Brian Wilcox, Robert M Silver, Neil J Perkins, Lindsey Sjaarda, Enrique F Schisterman
Elevated blood pressure in young adulthood is an early risk marker for cardiovascular disease. Despite a strong biological rationale, little research has evaluated whether incremental increases in preconception blood pressure have early consequences for reproductive health. We evaluated preconception blood pressure and fecundability, pregnancy loss, and live birth in the EAGeR trial (Effects of Aspirin on Gestational and Reproduction; 2007-2011), a randomized clinical trial of aspirin and reproductive outcomes among 1228 women attempting pregnancy with a history of pregnancy loss...
April 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29609193/female-sexual-function-in-women-with-suspected-deep-infiltrating-endometriosis
#19
Ryane Vieira Lima, Ana Maria Gomes Pereira, Fernando Bray Beraldo, Cláudia Gazzo, João Alfredo Martins, Reginaldo Guedes Coelho Lopes
OBJECTIVE:  To evaluate the quality of the sexual function of women with suspected deep infiltrating endometriosis. METHODS:  A cross-sectional, observational and prospective study was conducted between May 2015 and August 2016, in which 67 patients with deep infiltrating endometriosis, suspected or diagnosed, were assessed for epidemiological and clinical characteristics, such as pain level through a visual analog scale (VAS), features of deep infiltrating endometriosis lesions and score on the Female Sexual Function Index (FSFI) before the onset of treatment...
March 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29605411/efficacy-and-safety-of-pulsatile-gonadotropin-releasing-hormone-therapy-among-patients-with-idiopathic-and-functional-hypothalamic-amenorrhea-a-systematic-review-of-the-literature-and-a-meta-analysis
#20
Anastasios Tranoulis, Alexandros Laios, Andreas Pampanos, Drakoulis Yannoukakos, Dimitrios Loutradis, Lina Michala
OBJECTIVE: To systematically review and appraise the existing evidence in relation to the efficacy and safety of pulsatile gonadotropin-releasing hormone (pGnRH) for the treatment of women with hypothalamic amenorrhea (HA). DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): A total of 35 studies (three randomized and 32 observational) encompassing 1,002 women with HA. INTERVENTION(S): None...
March 28, 2018: Fertility and Sterility
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