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chronic musculoskeletal pain

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https://www.readbyqxmd.com/read/28315479/biopsychosocial-influence-on-shoulder-pain-rationale-and-protocol-for-a-pre-clinical-trial
#1
Steven Z George, Roland Staud, Paul A Borsa, Samuel S Wu, Margaret R Wallace, Warren H Greenfield, Lauren N Mackie, Roger B Fillingim
BACKGROUND: Chronic musculoskeletal pain conditions are a prevalent and disabling problem. Preventing chronic musculoskeletal pain requires multifactorial treatment approaches that address its complex etiology. Prior cohort studies identified a high risk subgroup comprised of variation in COMT genotype and pain catastrophizing. This subgroup had increased chance of heightened pain responses (in a pre-clinical model) and higher 12month post-operatives pain intensity ratings (in a clinical model)...
March 14, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28303458/calcitonin-gene-related-peptide-and-pain-a-systematic-review
#2
REVIEW
Wendy Sophie Schou, Sait Ashina, Faisal Mohammad Amin, Peter J Goadsby, Messoud Ashina
BACKGROUND: Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in migraine pathophysiology but its role in non-headache pain has not been clarified. METHODS: We performed a systematic literature search on PubMed, Embase and ClinicalTrials.gov for articles on CGRP and non-headache pain covering human studies including experimental studies and randomized clinical trials...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28302054/the-feasibility-of-matching-on-a-propensity-score-for-acupuncture-in-a-prospective-cohort-study-of-patients-with-chronic-pain
#3
Eric S Johnson, John F Dickerson, William M Vollmer, Alee M Rowley, Cheryl Ritenbaugh, Richard A Deyo, Lynn DeBar
BACKGROUND: Propensity scores are typically applied in retrospective cohort studies. We describe the feasibility of matching on a propensity score derived from a retrospective cohort and subsequently applied in a prospective cohort study of patients with chronic musculoskeletal pain before the start of acupuncture or usual care treatment and enrollment in a comparative effectiveness study that required patient reported pain outcomes. METHODS: We assembled a retrospective cohort study using data from 2010 to develop a propensity score for acupuncture versus usual care based on electronic healthcare record and administrative data (e...
March 16, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28299231/chronic-osteoporotic-pain-in-mice-cutaneous-and-deep-musculoskeletal-pain-are-partially-independent-of-bone-resorption-and-differentially-sensitive-to-pharmacological-interventions
#4
Miyako Suzuki, Magali Millecamps, Lina Naso, Seiji Ohtori, Chisato Mori, Laura S Stone
Although the pathological changes in osteoporotic bones are well established, the characterization of the osteoporotic pain and its appropriate treatment are not fully elucidated. We investigated the behavioral signs of cutaneous and deep musculoskeletal pain and physical function; time-dependent changes in bone mineral density (BMD) and the emergence of the behavioral phenotype; and the effects of pharmacological interventions having different mechanisms of action (chronic intraperitoneal administration of pamidronate [0...
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28297577/surgical-excision-of-heterotopic-ossification-leads-to-re-emergence-of-mesenchymal-stem-cell-populations-responsible-for-recurrence
#5
Shailesh Agarwal, Shawn Loder, David Cholok, John Li, Chris Breuler, James Drake, Cameron Brownley, Joshua Peterson, Shuli Li, Benjamin Levi
Trauma-induced heterotopic ossification (HO) occurs after severe musculoskeletal injuries and burns, and presents a significant barrier to patient rehabilitation. Interestingly, the incidence of HO significantly increases with repeated operations and after resection of previous HO. Treatment of established heterotopic ossification is challenging because surgical excision is often incomplete, with evidence of persistent heterotopic bone. As a result, patients may continue to report the signs or symptoms of HO, including chronic pain, nonhealing wounds, and joint restriction...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28296137/percutaneous-peripheral-nerve-stimulation-for-the-treatment-of-chronic-low-back-pain-two-clinical-case-reports-of-sustained-pain-relief
#6
Leonardo Kapural, Christopher A Gilmore, John Chae, Richard L Rauck, Steven P Cohen, Michael F Saulino, Amorn Wongsarnpigoon, Meredith J McGee, Joseph W Boggs
As the leading cause of disability among U.S. adults, chronic low back pain (LBP) is one sof the most prevalent and challenging musculoskeletal conditions. Neuromodulation provides an opportunity to reduce or eliminate the use of opioids to treat chronic LBP, but the cost and invasiveness of existing methods have limited its broad adoption, especially earlier in the treatment continuum. The present case report details the results of a novel method of short-term percutaneous peripheral nerve stimulation (PNS) in 2 subjects with chronic LBP...
March 14, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28284771/prevalence-of-musculoskeletal-manifestations-and-related-disabilities-in-a-peruvian-urban-population-living-at-high-altitude-copcord-study-stage-i
#7
Oscar Vega-Hinojosa, Mario H Cardiel, Pilar Ochoa-Miranda
OBJECTIVE: Estimate the prevalence of musculoskeletal manifestations and related disabilities of an urban population living at high altitude in Juliaca, Puno, Peru, using the Community Oriented Program for Control of Rheumatic Diseases (COPCORD) questionnaire and Health Assessment Questionnaire (HAQ) disability index. METHODS: A cross-sectional study was performed in a sample of 1095 people. In each interview, the COPCORD methodology and the HAQ were applied. The city was divided into 8 sectors...
March 8, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28284228/interactive-wearable-systems-for-upper-body-rehabilitation-a-systematic-review
#8
REVIEW
Qi Wang, Panos Markopoulos, Bin Yu, Wei Chen, Annick Timmermans
BACKGROUND: The development of interactive rehabilitation technologies which rely on wearable-sensing for upper body rehabilitation is attracting increasing research interest. This paper reviews related research with the aim: 1) To inventory and classify interactive wearable systems for movement and posture monitoring during upper body rehabilitation, regarding the sensing technology, system measurements and feedback conditions; 2) To gauge the wearability of the wearable systems; 3) To inventory the availability of clinical evidence supporting the effectiveness of related technologies...
March 11, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28282362/gene-to-gene-interactions-regulate-endogenous-pain-modulation-in-fibromyalgia-patients-and-healthy-controls-antagonistic-effects-between-opioid-and-serotonin-related-genes
#9
Tour Jeanette, Löfgren Monika, Mannerkorpi Kaisa, Gerdle Björn, Larsson Anette, Palstam Annie, Bileviciute-Ljungar Indre, Bjersing Jan, Ingvar Martin, Ernberg Malin, Schalling Martin, Kosek Eva
Chronic pain is associated with dysfunctional endogenous pain modulation, involving both central opioid and serotonergic (5-HT) signaling. Fibromyalgia (FM) is a chronic pain syndrome, characterized by widespread musculoskeletal pain and reduced exercise-induced hypoalgesia (EIH). In this study, we assessed the effects of three functional genetic polymorphisms on EIH in 130 patients with FM and 132 healthy controls (HC). Subjects were genotyped regarding the mu-opioid receptor (OPRM1) gene (rs1799971), the serotonin transporter (5-HTT) gene (5-HTTLPR/rs25531) and the serotonin-1a receptor (5-HT1a) gene (rs6296)...
March 7, 2017: Pain
https://www.readbyqxmd.com/read/28282361/use-of-analgesics-in-young-adults-as-a-predictor-of-health-care-utilization-and-pain-prevalence-israel-defense-forces-experience
#10
Karina Dorfman, Olga Komargodski, Racheli Magnezi, Stanislav Lifshitz, Dorit Tzur, Nirit Yavnai, Gal Ifergane
Pain evaluation in large community studies is difficult. Analgesics can be a useful tool in estimating pain related conditions in which analgesic use is highly regulated. In this study we evaluated analgesics consumption patterns of regular Israel Defense Force soldiers. We have performed a historical cohort study of 665,137 young adults during active duty in 2002-2012. Analgesics were prescribed to 518,242 (78%) soldiers, mostly for musculoskeletal pain (69.3%), abdominal pain (12.7%) and headache (12.1%)...
March 7, 2017: Pain
https://www.readbyqxmd.com/read/28277047/patients-with-chronic-pain-may-need-extra-support-when-prescribed-physical-activity-in-primary-care-a-qualitative-study
#11
Monica Joelsson, Susanne Bernhardsson, Maria E H Larsson
BACKGROUND: Physical activity plays an important role in the prevention and treatment of chronic musculoskeletal pain, but chronic pain may implicate a poor rehabilitation outcome. The concept of physical activity on prescription (PAP) is a therapeutic option for various diseases, but there is a lack of knowledge about how patients with chronic musculoskeletal pain experience receiving the prescription. OBJECTIVES: The objective of this study was to describe the experiences of and thoughts about receiving a prescription for physical activity of people with chronic musculoskeletal pain...
March 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/28274342/development-of-a-japanese-version-of-the-somatic-symptom-scale-8-psychometric-validity-and-internal-consistency
#12
Ko Matsudaira, Hiroyuki Oka, Mika Kawaguchi, Masato Murakami, Shin Fukudo, Makoto Hashizume, Bernd Löwe
OBJECTIVE: We aimed to psychometrically validate the Japanese version of the Somatic Symptom Scale-8 (SSS-8) in Japanese individuals. METHOD: Data were collected from Japanese individuals aged 20-64years, who were recruited online, in February 2015. The scale reliability and validity were analyzed. RESULTS: Data from 52,353 individuals were analyzed. Cronbach's alpha for the assessment of internal consistency reliability was 0.86 for the total score...
March 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28267103/psychosocial-factors-related-to-functional-restoration-treatment-completion-and-return-to-function-for-patients-with-chronic-disabling-occupational-musculoskeletal-disorders
#13
Krista J Howard, Ricardo A Castaneda, Avia L Gray, Kelly B Haskard-Zolnierek, Krista Jordan
OBJECTIVE: The aim of this study was to identify demographic and psychosocial variables associated with successful completion of a functional restoration program and return-to-function within 3 months of treatment completion. METHODS: Three hundred seven patients admitted to the functional restoration program were evaluated for completion status and 200 patients with valid data were assessed for 3-month return-to-function status following completion. Psychosocial and functional status was assessed at baseline...
March 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28263099/modulation-of-the-peripheral-immune-system-after-low-dose-radon-spa-therapy-detailed-longitudinal-immune-monitoring-of-patients-within-the-rad-on01-study
#14
Paul F Rühle, Roland Wunderlich, Lisa Deloch, Claudia Fournier, Andreas Maier, Gerhart Klein, Rainer Fietkau, Udo S Gaipl, Benjamin Frey
The pain-relieving effects of low-dose radon therapies on patients suffering from chronic painful inflammatory diseases have been described for centuries. Even though it has been suggested that low doses of radiation may attenuate chronic inflammation, the underlying mechanisms remain elusive. Thus, the RAD-ON01 study was initiated to examine the effects of radon spa therapy and its low doses of alpha radiation on the human immune system. In addition to an evaluation of pain parameters, blood was drawn from 100 patients suffering from chronic painful degenerative musculoskeletal diseases before as well as 6, 12, 18, and 30 weeks after the start of therapy...
March 2017: Autoimmunity
https://www.readbyqxmd.com/read/28255261/validation-of-the-french-version-of-the-patterns-of-activity-measure-in-patients-with-chronic-musculoskeletal-pain
#15
Charles Benaim, Bertrand Léger, Philippe Vuistiner, François Luthi
Background. The "Patterns of Activity Measure" (POAM-P) is a self-administered questionnaire that assesses "avoidance", "pacing" and "overdoing" activity patterns in chronic pain patients. Objectives. To adapt the POAM-P to French ("POAM-P/F") and test its validity and reliability in Chronic Musculo-Skeletal Pain patients (CMSP). Methods. We followed the recommended procedure for translation of questionnaires. Five hundred and ninety five inpatients, admitted to a tertiary rehab center in the French-speaking part of Switzerland for chronic pain after orthopedic trauma, were included (sex ratio M/F = 4...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/28248895/the-quebec-serve-protect-low-back-pain-study-a-web-based-cross-sectional-investigation-of-prevalence-and-functional-impact-among-police-officers
#16
Nabiha Benyamina Douma, Charles Côté, Anaïs Lacasse
STUDY DESIGN: . Web-based cross-sectional study. OBJECTIVE: Describe the prevalence and the burden of low back pain (LBP) and chronic low back pain (CLBP) amongQuebec police officers. SUMMARY OF BACKGROUND DATA: Police officers have work-related factors associated with LBP, but chronicity and impacts of this condition have been little exploredamong this population. METHODS: Between May and October 2014, a web-based cross-sectional study was conducted among police officers working in the province of Quebec (Canada)...
February 28, 2017: Spine
https://www.readbyqxmd.com/read/28244944/goals-of-chronic-pain-management-do-patients-and-primary-care-physicians-agree-and-does-it-matter
#17
Stephen G Henry, Robert A Bell, Joshua J Fenton, Richard L Kravitz
OBJECTIVE: Assess patient-physician agreement on management goals for chronic musculoskeletal pain and its associations with patient and physician visit experiences. MATERIALS AND METHODS: Previsit and postvisit questionnaires for 87 primary care visits involved patients taking opioids for chronic musculoskeletal pain and primary care residents. After each visit, patients and physicians independently ranked 5 pain treatment goals from most to least important. RESULTS: In total, 48% of patients ranked reducing pain intensity as their top priority, whereas 22% ranked finding a diagnosis as most important...
February 27, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28224414/does-the-length-of-disability-between-injury-and-functional-restoration-program-entry-affect-treatment-outcomes-for-patients-with-chronic-disabling-occupational-musculoskeletal-disorders
#18
Sali Asih, Randy Neblett, Tom G Mayer, Robert J Gatchel
Purpose Functional restoration programs (FRPs), for patients with chronic disabling occupational musculoskeletal disorders (CDOMDs), have consistently demonstrated positive socioeconomic treatment outcomes, including decreased psychosocial distress and increased work return. The pre-treatment length of disability (LOD), or time between injury and treatment admission, has been shown to influence FRP work outcomes. Some studies have found that shorter LOD is associated with better work outcomes. However, few studies have actually examined cohorts with LOD duration longer than 18 months...
February 21, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28222988/thirty-day-and-90-day-hospital-readmission-after-outpatient-upper-extremity-hemodialysis-access-creation
#19
Jeffrey J Siracuse, Nishant K Shah, Matthew R Peacock, Georges Tahhan, Jeffrey A Kalish, Denis Rybin, Mohammad H Eslami, Alik Farber
OBJECTIVE: Patients with end-stage renal disease have multiple comorbidities and are at increased risk for postoperative complications and resource utilization. Our goal was to determine the rate and causes of 30-day and 90-day hospital readmissions after the creation of outpatient hemodialysis access. METHODS: We retrospectively reviewed all outpatient upper extremity hemodialysis access creations performed at our medical center from 2008 to 2015. Readmission was defined as any inpatient status admission ≤30 and 90 days...
February 17, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28222382/corporeal-illusions-in-chronic-spinal-cord-injuries
#20
Michele Scandola, Salvatore Maria Aglioti, Renato Avesani, Gianettore Bertagnoni, Anna Marangoni, Valentina Moro
While several studies have investigated corporeal illusions in patients who have suffered from a stroke or undergone an amputation, only anecdotal or single case reports have explored this phenomenon after spinal cord injury. Here we examine various different types of bodily misperceptions in a comparatively large group of 49 people with spinal cord injury in the post-acute and chronic phases after the traumatic lesion onset. An extensive battery of questionnaires concerning a variety of body related feelings was administered and the results were correlated to the main clinical variables...
March 2017: Consciousness and Cognition
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