Qianqian Liang, Siqing Wang, Xinyan Zhou, Yongbo Li, Shenghui Xing, Yi'ou Sha, Fuling Yang, Wenjun Huang, Nanbo Liu, Zhetao Li, Yufei Chen, Yichi Xu, Ping Zhu, Fei Lan, Ning Sun
Heart development is controlled by a complex transcriptional network composed of transcription factors and epigenetic regulators. Mutations in key developmental transcription factor MESP1 and chromatin factors, such as PRC1 and cohesin components, have been found in human congenital heart diseases (CHDs), although their functional mechanism during heart development remains elusive. Here, we find that MESP1 interacts with RING1A/RING1, the core component of PRC1. RING1A depletion impairs human cardiomyocyte differentiation, and cardiac abnormalities similar to those in patients with MESP1 mutations were observed in Ring1A knockout mice...
November 21, 2022: Developmental Cell