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Angiopoietins

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https://www.readbyqxmd.com/read/29035390/epigenetic-silencing-of-the-dual-role-signal-mediator-angptl4-in-tumor-tissues-and-its-overexpression-in-the-urothelial-carcinoma-microenvironment
#1
H-Y Hsieh, Y-C Jou, C-L Tung, Y-S Tsai, Y-H Wang, C-L Chi, R-I Lin, S-K Hung, Y-M Chuang, S-F Wu, C Li, C-H Shen, M W Y Chan, C-D Hsu
Urothelial carcinoma (UC) carcinogenesis has been hypothesized to occur through epigenetic repression of tumor-suppressor genes (TSGs). By quantitative real-time polymerase chain reaction array, we found that one potential TSG, angiopoietin-like 4 (ANGPTL4), was expressed at very low levels in all bladder cancer cell lines we examined. Previous studies had demonstrated that ANGPTL4 is highly expressed in some cancers, but downregulated, by DNA methylation, in others. Consequently, owing to these seemingly conflicting functions in distinct cancers, the precise role of ANGPTL4 in the etiology of UC remains unclear...
October 16, 2017: Oncogene
https://www.readbyqxmd.com/read/29033485/correlation-of-long-term-glycemic-control-as-measured-by-glycated-hemoglobin-with-serum-angiopoietin-like-6-protein-levels-in-type-2-diabetes-mellitus-patients
#2
Vikaas Sharma, Ghan Shyam Pangtey, Rachna Gupta, Harmeet Singh Rehan, Lalit Kumar Gupta
AIMS: Angiopoietin-like growth factors (ANGPTLs) regulate glucose, lipid homeostasis, and insulin sensitivity. This study aimed to find whether long-term glycemic control (glycated hemoglobin [HbA1c]) has any correlation with serum ANGPTL6 levels in patients of type 2 diabetes mellitus. MATERIALS AND METHODS: It was an open-label, observational, prospective clinical study. Sixty-five participants (41 diabetic patients receiving daily dose of oral metformin for a minimum of 3 months and 24 matched controls) completed the study...
May 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29031892/altered-angiogenesis-as-a-common-mechanism-underlying-preterm-birth-small-for-gestational-age-and-stillbirth-in-women-living-with-hiv
#3
Andrea L Conroy, Chloe R Mcdonald, Joel L Gamble, Peter Olwoch, Paul Natureeba, Deborah Cohan, Moses R Kamya, Diane V Havlir, Grant Dorsey, Kevin C Kain
BACKGROUND: Angiogenic processes in the placenta are critical regulators of fetal growth and impact birth outcomes, but there are limited data documenting these processes in HIV-infected women or women from low-resource settings. OBJECTIVE: To determine whether angiogenic factors are associated with adverse birth outcomes in HIV-infected pregnant women started on antiretroviral therapy. STUDY DESIGN: This is a secondary analysis of samples collected as part of a clinical trial randomizing pregnant women infected with HIV to lopinavir/ritonavir (n=166) or efavirenz-based (n=160) antiretroviral therapy in Tororo, Uganda...
October 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29031854/angptl-4-induces-diabetic-retinal-inflammation-by-activating-profilin-1
#4
Qianyi Lu, Peirong Lu, Wei Chen, Li Lu, Zhi Zheng
Diabetic retinopathy (DR), the most common cause of irreversible blindness in working-age adults, results in central vision loss that is caused by microvascular damage to the inner lining of the back of the eye, the retina. The aim of this work was to assess the temporal relationships between angiopoietin-like protein-4 (ANGPTL-4), a novel adipocytokine factor, and diabetic retinal inflammation and microvascular dysfunction. The downstream pathway(s) and upstream mediator(s) of ANGPTL-4 were then determined under high glucose (HG) conditions...
October 12, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29031727/angiopoietin-like-protein-4-is-an-exercise-induced-hepatokine-in-humans-regulated-by-glucagon-and-camp
#5
Bodil Ingerslev, Jakob S Hansen, Christoph Hoffmann, Jens O Clemmesen, Niels H Secher, Mika Scheler, Martin Hrabĕ de Angelis, Hans U Häring, Bente K Pedersen, Cora Weigert, Peter Plomgaard
OBJECTIVE: Angiopoietin-like protein-4 (ANGPTL4) is a circulating protein that is highly expressed in liver and implicated in regulation of plasma triglyceride levels. Systemic ANGPTL4 increases during prolonged fasting and is suggested to be secreted from skeletal muscle following exercise. METHODS: We investigated the origin of exercise-induced ANGPTL4 in humans by measuring the arterial-to-venous difference over the leg and the hepato-splanchnic bed during an acute bout of exercise...
October 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29031715/angptl8-promotes-the-ability-of-angptl3-to-bind-and-inhibit-lipoprotein-lipase
#6
Xun Chi, Emily C Britt, Hannah W Shows, Alexander J Hjelmaas, Shwetha K Shetty, Emily M Cushing, Wendy Li, Alex Dou, Ren Zhang, Brandon S J Davies
OBJECTIVE: Several members of the angiopoietin-like (ANGPTL) family of proteins, including ANGPTL3 and ANGPTL8, regulate lipoprotein lipase (LPL) activity. Deficiency in either ANGPTL3 or ANGPTL8 reduces plasma triglyceride levels and increases LPL activity, whereas overexpression of either protein does the opposite. Recent studies suggest that ANGPTL8 may functionally interact with ANGPTL3 to alter clearance of plasma triglycerides; however, the nature of this interaction has remained elusive...
October 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29029943/bcg-immune-activation-reduces-growth-and-angiogenesis-in-an-in-vitro-model-of-head-and-neck-squamous-cell-carcinoma
#7
Carolina Sánchez-Rodríguez, Keyliz Peraza Cruces, Juan Riestra Ayora, Eduardo Martín-Sanz, Ricardo Sanz-Fernández
Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers worldwide and is associated with poor survival and significant treatment morbidity. The immune profile in patients with HNSCC is immunosuppressive and presents cytokine-mediated adaptive immune responses, triggered apoptosis of T cells, and alterations in antigen processing machinery. Bacille Calmette-Guerin (BCG) immunotherapy has been used successfully as a treatment for several types of cancer. In the present study, we sought to determine the antitumor effect of soluble mediators from peripheral blood mononuclear immune cells (PBMCs) activated with BCG vaccine in a three-dimensional coculture model of HNSCC growth using FaDu hypopharynx carcinoma squamous cells...
October 10, 2017: Vaccine
https://www.readbyqxmd.com/read/29017512/metastatic-pathway-and-the-microvascular-and-physicochemical-microenvironments-of-human-melanoma-xenografts
#8
Ruixia Huang, Lise Mari K Andersen, Einar K Rofstad
BACKGROUND: Malignant melanoma of the skin can metastasize through blood vessels and lymphatics. The primary tumor develops a vascular microenvironment characterized by abnormal blood vessels and lymphatics and a physicochemical microenvironment characterized by low oxygen tension, regions with hypoxic tissue, and high interstitial fluid pressure (IFP). This study aimed at identifying relationships between the metastatic route of melanomas and characteristic features of the microvascular and physicochemical microenvironments of the primary tumor...
October 10, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29017031/angiopoietin-like-4-is-a-wnt-signaling-antagonist-that-promotes-lrp6-turnover
#9
Nadine Kirsch, Ling-Shih Chang, Stefan Koch, Andrey Glinka, Christine Dolde, Gabriele Colozza, Maria D J Benitez, Edward M De Robertis, Christof Niehrs
Angiopoietin-like 4 (ANGPTL4) is a secreted signaling protein that is implicated in cardiovascular disease, metabolic disorder, and cancer. Outside of its role in lipid metabolism, ANGPTL4 signaling remains poorly understood. Here, we identify ANGPTL4 as a Wnt signaling antagonist that binds to syndecans and forms a ternary complex with the Wnt co-receptor Lipoprotein receptor-related protein 6 (LRP6). This protein complex is internalized via clathrin-mediated endocytosis and degraded in lysosomes, leading to attenuation of Wnt/β-catenin signaling...
October 9, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28984319/angiopoietin-like-3-in-lipoprotein-metabolism
#10
REVIEW
Sander Kersten
Triglycerides and cholesterol circulate in the bloodstream as part of various lipoprotein particles. Three members of the angiopoietin-like (ANGPTL) protein family - ANGPTL3, ANGPTL4 and ANGPTL8 - have emerged as important regulators of plasma lipoprotein levels by inhibiting the enzyme lipoprotein lipase. Here, I review the role of ANGPTL3 in lipoprotein metabolism. In contrast to ANGPTL4 and ANGPTL8, ANGPTL3 is exclusively produced in the liver and can therefore be classified as a true hepatokine. ANGPTL3 cooperates with ANGPTL8 to inhibit lipoprotein lipase and is mostly active after feeding, whereas ANGPTL4 is mostly active after fasting...
October 6, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28981191/retinoic-acid-receptor-%C3%AE-regulates-synthetic-events-in-human-platelets
#11
Hansjörg Schwertz, Jesse W Rowley, Guy A Zimmerman, Andrew S Weyrich, Matthew T Rondina
BACKGROUND: Translational control mechanisms in platelets are incompletely defined. Here, we determined whether the nuclear transcription factor RARα controls protein translational events in human platelets. METHODS: Isolated human platelets were treated with the pan-RAR agonist all-trans-retinoic acid (atRA). Global and targeted translational events were examined. RESULTS: Stimulation of platelets with (atRA) significantly increased global protein expression...
October 5, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28979738/role-of-angiopoietins-and-tie-2-in-diabetic-retinopathy
#12
Nervana Khalaf, Hazem Helmy, Hany Labib, Iman Fahmy, Mona Abd El Hamid, Leqaa Moemen
OBJECTIVE: The aim of this study was to determine the serum levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), soluble vascular endothelial tyrosine kinase receptor (Tie-2) and vascular endothelial growth factor (VEGF), in the serum of type 2 diabetic patients having non-proliferative (NPDR) or proliferative diabetic retinopathy (PDR). METHODS: One hundred patients with type 2 diabetes mellitus were involved in this cross-sectional study. They were classified into 25 diabetic patients without retinopathy, 35 patients with NPDR and 40 PDR patients...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28974056/friends-turned-foes-angiogenic-growth-factors-beyond-angiogenesis
#13
REVIEW
Pratiek N Matkar, Ramya Ariyagunarajah, Howard Leong-Poi, Krishna K Singh
Angiogenesis, the formation of new blood vessels from pre-existing ones is a biological process that ensures an adequate blood flow is maintained to provide the cells with a sufficient supply of nutrients and oxygen within the body. Numerous soluble growth factors and inhibitors, cytokines, proteases as well as extracellular matrix proteins and adhesion molecules stringently regulate the multi-factorial process of angiogenesis. The properties and interactions of key angiogenic molecules such as vascular endothelial growth factors (VEGFs), fibroblast growth factors (FGFs) and angiopoietins have been investigated in great detail with respect to their molecular impact on angiogenesis...
October 2, 2017: Biomolecules
https://www.readbyqxmd.com/read/28972399/angptl3-serum-concentration-and-rare-genetic-variants-in-finnish-population
#14
Anna Tikka, Jari Metso, Matti Jauhiainen
Genetic variants of angiopoietin-like protein 3 (ANGPTL3) are associated with serum triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) concentration in GWASs. ANGPTL3 deficiency causes declined TG, total cholesterol (TC), LDL-C, high-density lipoprotein cholesterol (HDL-C), apolipoprotein B (apoB) and apolipoprotein A-I (apoA-I) serum concentration, a phenotype defined as familial combined hypolipidaemia (FHBL2). Our aim is to establish whether ANGPTL3 serum protein concentration correlates with lipoproteins and lipids in hyper- or hypolipidaemic subjects, and whether ANGPTL3 sequence variants are associated with untypical lipid profiles...
October 3, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28971105/angplt3-a-novel-modulator-of-lipid-metabolism
#15
REVIEW
Mohamed Hassan
Angiopoietin-like proteins (ANGPTLs) have emerged as an important regulator of lipid and glucose metabolism as well as insulin sensitivity. ANGPTL3 plays a key role in regulating circulating triglycerides (TG) and cholesterol levels through reversible inhibition of lipoprotein lipase (LPL) and endothelial lipase enzymes activity. Loss of function mutation of ANGPTL3 gene has been identified in many subjects with familial combined hypolipidemia. ANGPTL4 produces irreversible inhibition of LPL activity, while ANGPTL8 enhances the activity of ANGPTL3, which highlight the interplay between the different ANGPTLs in a coordinated manner to regulate lipid metabolism during different nutritional states...
March 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/28970657/vasopressin-in-septic-shock-assessment-of-sepsis-biomarkers-a-randomized-controlled-trial
#16
Elchin Barzegar, Masoumeh Nouri, Sarah Mousavi, Arezoo Ahmadi, Mojtaba Mojtahedzadeh
BACKGROUND AND AIMS: Vasopressin (VP) in sepsis apart from vasoconstrictive effect may have some immunomodulatory effects. The aim of this study was to evaluate the effect of VP on different aspect of sepsis by measuring of sepsis biomarkers. MATERIALS AND METHODS: In this trial, a total number of 42 septic shock patients were included. The first group received norepinephrine (NE) infusion to reach the target mean arterial pressure (MAP) of ≥ 65 mm Hg and the second group received arginine vasopressin (AVP) infusion in addition to NE...
September 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28968277/vasculotide-an-angiopoietin-1-mimetic-restores-microcirculatory-perfusion-and-microvascular-leakage-and-decreases-fluid-resuscitation-requirements-in-hemorrhagic-shock
#17
Michelle Trieu, Matijs van Meurs, Anoek L I van Leeuwen, Paul Van Slyke, Van Hoang, Leo M G Geeraedts, Christa Boer, Charissa E van den Brom
BACKGROUND: Microcirculatory dysfunction is associated with multiple organ failure and unfavorable patient outcome. We investigated whether therapeutically targeting the endothelial angiopoietin/Tie2 system preserves microvascular integrity during hemorrhagic shock. METHODS: Rats were treated with the angiopoietin-1 mimetic Vasculotide and subjected to hemorrhagic shock and fluid resuscitation. Microcirculatory perfusion and leakage were assessed with intravital microscopy (n = 7 per group) and Evans blue dye extravasation (n = 8 per group), respectively...
September 29, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28967470/involvement-of-synovial-matrix-degradation-and-angiogenesis-in-oxidative-stress-exposed-degenerative-rotator-cuff-tears-with-osteoarthritis
#18
Kyu-Cheol Noh, Sin-Hye Park, Cheol Jung Yang, Geun Woo Lee, Min Ki Kim, Young-Hee Kang
BACKGROUND: Shoulder osteoarthritis is a gradual wearing of the articular cartilage concomitant with degenerative rotator cuff tears (RCTs). This pathologic disorder is related to inflammation, oxidative stress, and angiogenesis. Degenerative alterations may prompt production of cytokines and angiogenesis-related proteins, evoking rotator cuff diseases. This study tested the hypothesis that oxidative stress-responsive mediators can influence joint inflammation of patients with RCT. METHODS: Twelve healthy RCT patients not suffering shoulder osteoarthritis were categorized as the control group, and 24 patients were allocated to 2 RCT groups (RCTP1 and RCTP2), according to severity of RCT and glenohumeral arthritis...
September 26, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28965028/angiopoietin-like-protein-8-an-attractive-biomarker-for-the-evaluation-of-subjects-with-insulin-resistance-and-related-disorders
#19
REVIEW
Su Wang, Xiafei Hong, Zhigang Tu, Guoyue Yuan
Insulin resistance is prevalent worldwide and is associated with many metabolic diseases, in particular, type 2 diabetes mellitus (T2DM), obesity, nonalcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS) and metabolic syndrome (MetS). Angiopoietin-like protein 8 (ANGPTL8), a newly-identified secreted protein composing of 198 amino acids, is enriched in the liver of human. Considering its promising potential for β-cell proliferation and therapeutic prospect for diabetes, ANGPTL8 has aroused extensive interests...
September 8, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28964418/serum-biomarkers-may-prognosticate-recurrence-in-node-negative-non-small-cell-lung-cancers-less-than-4-centimeters
#20
Christopher W Seder, Andrew T Arndt, Lia Jordano, Sanjib Basu, Cristina L Fhied, Selina Sayidine, Gary W Chmielewski, Kelsey Gallo, Michael J Liptay, Jeffrey A Borgia
BACKGROUND: A significant proportion of patients who undergo lung resection for less than 4 cm non-small cell lung cancer (NSCLC) will die of disease recurrence within 5 years. The ability to identify patients at greatest risk for recurrence may help individualize treatment and surveillance regimens and improve outcomes. We hypothesized that a serum-based biomarker panel could help risk stratify patients with node-negative NSCLC less than 4 cm for recurrence after lung resection. METHODS: An institutional biorepository of more than 1,800 cases was used to identify patients with resected, node-negative NSCLC less than 4 cm in size...
September 27, 2017: Annals of Thoracic Surgery
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