keyword
MENU ▼
Read by QxMD icon Read
search

Angiopoietins

keyword
https://www.readbyqxmd.com/read/29221972/angiopoietin-like-proteins-4-angptl4-gene-polymorphisms-and-risk-of-brain-arteriovenous-malformation
#1
Sarafroz A Erkinova, Ekaterina A Sokolova, Kirill Y Orlov, Vitaly S Kiselev, Nikolay V Strelnikov, Andrey V Dubovoy, Elena N Voronina, Maxim L Filipenko
BACKGROUND: Brain arteriovenous malformations (BAVMs) are formed by hypertrophied arterial vessels (afferents, feeders), a large number of arteriovenous shunts which become tangled to form a body (nidus) of malformation, which then expands draining proximal veins. The aim of this study was a replication of single nucleotide polymorphism (SNP) rs11672433 association with BAVM development with the subsequent meta-analysis of published data. METHODS: A total of 252 Russian patients with brain BAVMs and 480 control subjects were included in the present study...
December 5, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29221165/angiogenesis-in-adenosquamous-cancer-of-pancreas
#2
Nicola Silvestris, Katia Danza, Vito Longo, Oronzo Brunetti, Livia Fucci, Antonella Argentiero, Angela Calabrese, Ivana Cataldo, Roberto Tamma, Domenico Ribatti, Stefania Tommasi
Adenosquamous carcinoma of the pancreas (ASCP) is an uncommon variant of exocrine pancreatic malignancies, characterized by a histological admixture of adenomatous and squamous cell elements. This cancer is characterized by a poorly differentiated histology and a poorer clinical outcome compared to pancreatic ductal adenocarcinoma (PDAC). Unlike PDAC, that is characterized by a low microvascular density (MVD) and collapsed vasculature, no data are available about angiogenesis in ASPC. Immunohistochemical evaluation of MVD and trypatse-positive mast cells (MCs) were performed on a single case of ASCP compared to PDAC...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218246/angiopoietin-like-protein-2-facilitates-non-small-cell-lung-cancer-progression-by-promoting-the-polarization-of-m2-tumor-associated-macrophages
#3
Xiaojuan Wei, Siyue Nie, Hui Liu, Jingyu Sun, Jie Liu, Juan Li, Shuyan Li, Shuyun Wang, Shuyi Han, Jun Wang, Yuping Sun
The functional phenotypes (M1 and M2) of tumor-associated macrophages (TAMs) are influenced by the tumor microenvironment (TME) and contribute greatly to the development of non-small cell lung cancer (NSCLC). However, the molecular mechanisms for TAM polarization remain unclear. Angiopoietin-like protein 2 (Angptl2) is involved in tumor progression. In this study, Angptl2 expression was aberrantly increased in NSCLC cells and positively correlated with TAM infiltration, tumor size and poor patient survival...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29217526/first-in-human-phase-i-study-of-single-agent-vanucizumab-a-first-in-class-bi-specific-anti-ang-2-anti-vegf-antibody-in-adult-patients-with-advanced-solid-tumors
#4
Manuel Hidalgo, Maria Martinez-Garcia, Christophe Le Tourneau, Christophe Massard, Elena Garralda, Valentina Boni, Alvaro Taus, Joan Albanell, Marie-Paule Sablin, Marie Alt, Rastilav Bahleda, Andreea Varga, Christophe Boetsch, Izolda Franjkovic, Florian Heil, Angelika Lahr, Katharina Lechner, Anthony Morel, Tapan K Nayak, Simona Rossomanno, Kevin Smart, Kay-Gunnar Stubenrauch, Oliver Krieter
PURPOSE: Vanucizumab is an investigational anti-angiogenic, first-in-class, bi-specific monoclonal antibody targeting VEGF-A and angiopoietin-2 (Ang-2). This first-in-human study evaluated the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of vanucizumab in adults with advanced solid tumors refractory to standard therapies. EXPERIMENTAL DESIGN: Patients received escalating bi-weekly (q2w; 3-30 mg/kg) or weekly (qw; 10-30 mg/kg) intravenous doses guided by a Bayesian logistic regression model with overdose control...
December 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29212955/myeloperoxidase-derived-2-chlorofatty-acids-contribute-to-human-sepsis-mortality-via-acute-respiratory-distress-syndrome
#5
Nuala J Meyer, John P Reilly, Rui Feng, Jason D Christie, Stanley L Hazen, Carolyn J Albert, Jacob D Franke, Celine L Hartman, Jane McHowat, David A Ford
Sepsis-associated acute respiratory distress syndrome (ARDS) is characterized by neutrophilic inflammation and poor survival. Since neutrophil myeloperoxidase (MPO) activity leads to increased plasma 2-chlorofatty acid (2-ClFA) levels, we hypothesized that plasma concentrations of 2-ClFAs would associate with ARDS and mortality in subjects with sepsis. In sequential consenting patients with sepsis, free 2-ClFA levels were significantly associated with ARDS, and with 30-day mortality, for each log increase in free 2-chlorostearic acid...
December 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/29212268/comp-angiopoietin-1-mitigates-changes-in-lipid-droplet-size-macrophage-infiltration-of-adipose-tissue-and-renal-inflammation-in-streptozotocin-induced-diabetic-mice
#6
Yu Jin Jung, Woong Park, Tung Nguyen-Thanh, Kyung Pyo Kang, Heung Young Jin, Suhn Hee Kim, Wonhee Suh, Won Kim
Adipose tissue is considered to be an endocrine organ, and adipocyte size correlates with insulin resistance and metabolic parameters in obesity. There is little data on the effects of angiopoietin-1 in adipose tissue and kidney in streptozotocin (STZ)-induced diabetes. In this study, we investigated the protective effect of COMP-angiopoietin-1 (COMP-Ang1), a potent variant of angiopoietin-1, on vascular endothelial cells in epididymal adipose tissue and its regulatory effect on other metabolic parameters, such as lipid droplet diameter, macrophage infiltration, and renal inflammation in STZ-treated mice...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211847/changes-in-neuronal-signaling-and-cell-stress-response-pathways-are-associated-with-a-multigenic-response-of-drosophila-melanogaster-to-ddt-selection
#7
Keon Mook Seong, Brad S Coates, Weilin Sun, John M Clark, Barry R Pittendrigh
The adaptation of insect populations to insecticidal control is a continual threat to human health and sustainable agricultural practices, but many complex genomic mechanisms involved in this adaption remain poorly understood. This study applied a systems approach to investigate the interconnections between structural and functional variance in response to dichlorodiphenyltrichloroethane (DDT) within the Drosophila melanogaster strain 91-R. Directional selection in six selective sweeps coincided with constitutive gene expression differences in DDT resistant flies, including the most highly up-regulated transcript, Unc-115b, which plays a central role in axon guidance, and the most highly down-regulated transcript, the angiopoietin-like CG31832, which is involved in directing vascular branching and dendrite outgrowth but likely under trans-regulatory control...
December 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29210175/site-specific-and-endothelial-mediated-dysfunction-of-the-alveolar-capillary-barrier-in-response-to-lipopolysaccharides
#8
Harshavardhan Janga, Liam Cassidy, Fanlu Wang, Dietmar Spengler, Stefanie Oestern-Fitschen, Martin F Krause, Andreas Seekamp, Andreas Tholey, Sabine Fuchs
Infectious agents such as lipopolysaccharides (LPS) challenge the functional properties of the alveolar-capillary barrier (ACB) in the lung. In this study, we analyse the site-specific effects of LPS on the ACB and reveal the effects on the individual cell types and the ACB as a functional unit. Monocultures of H441 epithelial cells and co-cultures of H441 with endothelial cells cultured on Transwells® were treated with LPS from the apical or basolateral compartment. Barrier properties were analysed by the transepithelial electrical resistance (TEER), by transport assays, and immunostaining and assessment of tight junctional molecules at protein level...
December 5, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29202127/obesity-does-not-exacerbate-the-protumorigenic-systemic-environment-in-sarcoma-subjects
#9
Claire M Buchta, Shannon K Boi, Benjamin J Miller, Mohammed M Milhem, Lyse A Norian
Sarcomas are a rare but fatal tumor type that accounts for <1% of adult solid malignancies and ~15% of childhood malignancies. Although the use of immunotherapy is being actively investigated for other solid tumors, advances in immunotherapy for sarcoma patients are lacking. To better understand the systemic immune environment in sarcoma patients, we performed a detailed multiplex analysis of serum cytokines, chemokines, and protumorigenic factors from treatment-naive subjects with localized, high-grade sarcoma...
June 1, 2017: ImmunoHorizons
https://www.readbyqxmd.com/read/29198436/reprogramming-tumor-blood-vessels-for-enhancing-immunotherapy
#10
Martina Schmittnaegel, Michele De Palma
Angiogenic blood vessels contribute to generating an immunosuppressive tumor microenvironment, in part by limiting the extravasation of T cells. Functional reprogramming of angiogenic blood vessels, for example through angiopoietin-2 blockade, may improve T cell trafficking in tumors and the efficacy of immune checkpoint blockade (ICB) and other cancer immunotherapies.
December 2017: Trends in Cancer
https://www.readbyqxmd.com/read/29197611/overexpression-of-angiopoietin-1-potentiates-endothelial-progenitor-cells-treatment-of-aneurysm
#11
Ziming Lu, Qiujing Wang, Chengwei Chen, Yuyuan Gao, Jian He, Wenchao Liu, Zhenjun Li, Zhenghui Zhao
OBJECTIVES: To investigate whether Angiopoietin-1(Ang-1) could regulate the endothelial progenitor cells(EPCs) survival and the effect of accelerating intra-aneurysmal organization and occlusion of the aneurysm neck. METHODS: EPCs were isolated from Wistar rats. EPCs were cultured and transfected with lentivirus-Ang-1(Ang-1-EPCs) and lentivirus-NC(NC-EPCs). The effects of Ang-1 on viability and functioning of EPCs were explored via tube formation, migration and MTT assays...
November 29, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29192516/knockdown-of-angiopoietin-like-2-mimics-the-benefits-of-intermittent-fasting-on-insulin-responsiveness-and-weight-loss
#12
Cécile Martel, Anthony Pinçon, Alexandre Maxime Bélanger, Xiaoyan Luo, Marc-Antoine Gillis, Olivia de Montgolfier, Nathalie Thorin-Trescases, Éric Thorin
Angiopoietin-like 2 (ANGPTL2) is an inflammatory adipokine linking obesity to insulin resistance. Intermittent fasting, on the other hand, is a lifestyle intervention able to prevent obesity and diabetes but difficult to implement and maintain. Our objectives were to characterize a link between ANGPTL2 and intermittent fasting and to investigate whether the knockdown of ANGPTL2 reproduces the benefits of intermittent fasting on weight gain and insulin responsiveness in knockdown and wild-type littermates mice...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29191837/age-dependent-increase-in-angiopoietin-like-protein-2-accelerates-skeletal-muscle-loss-in-mice
#13
Jiabin Zhao, Zhe Tian, Tsuyoshi Kadomatsu, Peiyu Xie, Keishi Miyata, Taichi Sugizaki, Motoyoshi Endo, Shunshun Zhu, Haoqiu Fan, Haruki Horiguchi, Jun Morinaga, Kazutoyo Terada, Tatsuya Yoshizawa, Kazuya Yamagata, Yuichi Oike
Skeletal muscle atrophy, or sarcopenia, is commonly observed in older individuals and in those with chronic disease and is associated with decreased quality of life. There is recent medical and broad concern that sarcopenia is rapidly increasing worldwide as populations age. At present, strength training is the only effective intervention for preventing sarcopenia development, but it is not known how this exercise regimen counteracts this condition. Here, we report that expression of the inflammatory mediator angiopoietin-like protein 2 (ANGPTL2) increases in skeletal muscle of aging mice...
November 30, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29191670/short-term-cooling-increases-serum-angiopoietin-like-4-levels-in-healthy-lean-men
#14
Kimberly J Nahon, Geerte Hoeke, Leontine E H Bakker, Ingrid M Jazet, Jimmy F P Berbée, Sander Kersten, Patrick C N Rensen, Mariëtte R Boon
BACKGROUND: Cold exposure enhances sympathetic outflow to peripheral tissues, thereby stimulating intracellular lipolysis in white adipose tissue and increasing the lipoprotein lipase-dependent uptake and combustion of triglyceride-derived fatty acids (FAs) by brown adipose tissue. Angiopoietin-like 4 (ANGPTL4) inhibits lipoprotein lipase and can be regulated by cold exposure, at least in mice. OBJECTIVE: In the present study, we examined the effect of short-term mild cooling on serum ANGPTL4 levels in healthy lean men of White Caucasian and South Asian descent...
November 1, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29191392/cold-atmospheric-plasma-cap-activates-angiogenesis-related-molecules-in-skin-keratinocytes-fibroblasts-and-endothelial-cells-and-improves-wound-angiogenesis-in-an-autocrine-and-paracrine-mode
#15
Stephanie Arndt, Petra Unger, Mark Berneburg, Anja-Katrin Bosserhoff, Sigrid Karrer
BACKGROUND: Cold atmospheric plasma (CAP) emerged as a novel therapeutic field with applications developed for bacterial sterilization, wound healing and cancer treatment. For clinical implementation it is important to know how CAP works and which molecular changes occur after the CAP treatment. Vascularization is an important step during wound healing, however, the effects of CAP on wound angiogenesis are not well examined so far. Furthermore, it has not been investigated, whether CAP primarily affects endothelial cells directly or via paracrine mechanisms to modulate the vasculature...
November 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29190499/crosstalk-between-developing-vasculature-and-optogenetically-engineered-skeletal-muscle-improves-muscle-contraction-and-angiogenesis
#16
Tatsuya Osaki, Vivek Sivathanu, Roger D Kamm
Capillary networks surrounding skeletal muscle play an important role in not only supplying oxygen and nutrients but also in regulating the myogenesis and repair of skeletal muscle tissues. Herein, we model the early stages of 3D vascularized muscle fiber formation in vitro using a sequential molding technique to investigate interactions between angiogenesis of endothelial cells and myogenesis of skeletal muscle cells. Channelrhodopsin-2 C2C12 muscle fiber bundles and 3D vascular structures (600 μm diameter) were formed at 500 μm intervals in a collagen gel...
November 25, 2017: Biomaterials
https://www.readbyqxmd.com/read/29190292/tnf-%C3%AE-blockade-suppresses-pericystic-inflammation-following-anthelmintic-treatment-in-porcine-neurocysticercosis
#17
Siddhartha Mahanty, Miguel A Orrego, Carla Cangalaya, M Paz Adrianzen, Gianfranco Arroyo, Juan Calcina, Armando E Gonzalez, Héctor H García, Cristina Guerra-Giraldez, Theodore E Nash
BACKGROUND: Neurocysticercosis (NCC) is an infection of the brain with the larval cyst of the tapeworm, Taenia solium. Cysticidal treatment induces parasite killing resulting in a post inflammatory response and seizures, which generally requires corticosteroid treatment to control inflammation. The nature of this response and how to best control it is unclear. We investigated the anti-inflammatory effects of pretreatment with etanercept (ETN), an anti-tumor necrosis factor agent, or dexamethasone (DEX), a high potency corticosteroid, on the post treatment inflammatory response in naturally infected pigs with neurocysticercosis after a single dose of the cysticidal drug praziquantel (PZQ)...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29183623/role-of-angiopoietin-like-3-angptl3-in-regulating-plasma-level-of-low-density-lipoprotein-cholesterol
#18
Yu-Xin Xu, Valeska Redon, Haojie Yu, William Querbes, James Pirruccello, Abigail Liebow, Amy Deik, Kevin Trindade, Xiao Wang, Kiran Musunuru, Clary B Clish, Chad Cowan, Kevin Fizgerald, Daniel Rader, Sekar Kathiresan
BACKGROUND AND AIMS: Angiopoietin-like 3 (ANGPTL3) has emerged as a key regulator of lipoprotein metabolism in humans. Homozygous loss of ANGPTL3 function causes familial combined hypolipidemia characterized by low plasma levels of triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). While known effects of ANGPTL3 in inhibiting lipoprotein lipase and endothelial lipase contribute to the low TG and HDL-C, respectively, the basis of low LDL-C remains unclear...
September 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29180303/effects-of-erythropoietin-on-astrocytes-and-brain-endothelial-cells-in-primary-culture-during-anoxia-depend-on-simultaneous-signaling-by-other-cytokines-and-on-duration-of-anoxia
#19
Hameed Al-Sarraf, Slava Malatiali, Mariam Al-Awadi, Zoran Redzic
Studies on animals revealed neuroprotective effects of exogenously applied erythropoietin (EPO) during cerebral ischemia/hypoxia. Yet, application of exogenous EPO in stroke patients often lead to haemorrhagic transformation. To clarify potential mechanism of this adverse effect we explored effects of EPO on viabilities of astrocytes and brain endothelial cells (BECs) in primary culture during anoxia of various durations, in the presence or absence of vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang1), which are cytokines that are also released from the neurovascular unit during hypoxia...
November 24, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29178246/effects-of-the-antagomirs-15b-and-200b-on-the-altered-healing-pattern-of-diabetic-mice
#20
Gabriele Pizzino, Natasha Irrera, Federica Galfo, Giovanni Pallio, Federica Mannino, Angelica D'amore, Enrica Pellegrino, Antonio Ieni, Giuseppina T Russo, Marco Calapai, Domenica Altavilla, Francesco Squadrito, Alessandra Bitto
BACKGROUND AND PURPOSE: Diabetic subjects with non-healing ulcers have a reduced expression of vascular endothelial growth factor (VEGF). Genetically diabetic mice have an altered expression pattern of VEGF and its receptor, VEGFR-2. In diabetic wounds, miR15b and miR200b which respectively inhibit VEGF and VEGF-R2 mRNAs are up-regulated, further affecting the impaired angiogenesis. We investigated whether anti-miRs directed toward miR15b and miR200b could improve wound repair in genetically diabetic mice...
November 26, 2017: British Journal of Pharmacology
keyword
keyword
93952
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"