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https://www.readbyqxmd.com/read/29929012/non-coding-rnas-in-lipid-metabolism
#1
REVIEW
Xinbo Zhang, Nathan L Price, Carlos Fernández-Hernando
Cardiovascular disease (CVD), the leading cause of death and morbidity in the Western world, begins with lipid accumulation in the arterial wall, which is the initial step in atherogenesis. Alterations in lipid metabolism result in increased risk of cardiometabolic disorders, and treatment of lipid disorders remains the most common strategy aimed at reducing the incidence of CVD. Work done over the past decade has identified numerous classes of non-coding RNA molecules including microRNAs (miRNAs) and long-non-coding RNAs (lncRNAs) as critical regulators of gene expression involved in lipid metabolism and CVD, mostly acting at post-transcriptional level...
June 18, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29928949/impaired-local-translation-of-%C3%AE-actin-mrna-in-ighmbp2-deficient-motoneurons-implications-for-spinal-muscular-atrophy-with-respiratory-distress-smard1
#2
Verena Surrey, Caren Zöller, Alicia Andrea Lork, Mehri Moradi, Stefanie Balk, Benjamin Dombert, Lena Saal-Bauernschubert, Michael Briese, Silke Appenzeller, Utz Fischer, Sibylle Jablonka
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a fatal motoneuron disorder in children with unknown etiology. The disease is caused by mutations in the IGHMBP2 gene, encoding a Super Family 1 (SF1)-type RNA/DNA helicase. IGHMBP2 is a cytosolic protein that binds to ribosomes and polysomes, suggesting a role in mRNA metabolism. Here we performed morphological and functional analyses of isolated Ighmbp2 deficient motoneurons to address the question whether the SMARD1 phenotype results from de-regulation of protein biosynthesis...
June 18, 2018: Neuroscience
https://www.readbyqxmd.com/read/29928929/site-specific-differences-in-osteoblast-phenotype-mechanical-loading-response-and-estrogen-receptor-related-gene-expression
#3
Borzo Gharibi, Mandeep S Ghuman, Giuseppe Cama, Simon C F Rawlinson, Agamemnon E Grigoriadis, Francis J Hughes
The osteoporosis-resistant nature of skull bones implies inherent differences exist between their cellular responses and those of other osteoporosis-susceptible skeletal sites. Phenotypic differences in calvarial and femoral osteoblastic responses to induction of osteogenesis, mechanical loading, estrogen, growth factor and cytokine stimulation were investigated. Primary rat calvarial and femoral adult male osteoblasts were cultured and osteoblastic mineralisation and maturation determined using Alizarin Red staining and expression of osteogenic marker genes assessed...
June 18, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29928760/mild-electrical-stimulation-with-heat-shock-reduces-the-inflammatory-symptoms-in-imiquimod-induced-psoriasis-mouse-model
#4
Yu Tsurekawa, Misaki Morita, Mary Ann Suico, Masataka Moriuchi, Yoshio Nakano, Mariam Piruzyan, Masafumi Takada, Sanako Fukami, Tsuyoshi Shuto, Hirofumi Kai
Psoriasis is a chronic skin disease caused by immune disorder. The chronic skin inflammation involves inflammatory molecules that are released from T lymphocytes and keratinocytes. Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces biological responses by modulating intracellular signaling pathways. Our previous studies showed that the optimized combination treatment of mild electrical stimulation (MES, 0.1-millisecond; ms, 55-pulses per second; pps) and heat shock (HS, 42°C) modulates inflammatory symptoms of metabolic disorders and chronic kidney disease in mice models and clinical trials...
June 21, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29928151/a-rare-case-of-rem-sleep-related-bradyarrhythmia-syndrome-with-concomitant-severe-hypertension-a-case-report-and-a-review-of-literature
#5
Gabrielius Jakutis, Vytautas Juknevičius, Juratė Barysienė, Dalia Matačiūnienė, Birutė Petrauskienė, Žaneta Petrulionienė, Aleksandras Laucevičius
Introduction: Rapid eye movement (REM) sleep-related bradyarrhythmia syndrome is characterized by pathological asystoles during the REM sleep phase. It is a rare rhythm disorder, being reported only few times in the literature. Due to non-specific symptoms, REM sleep-related bradyarrhythmia might be often underdiagnosed. Other cardiac diseases associated with pathological sinus arrests must be excluded to establish the correct diagnosis of and appropriate therapy for REM sleep-related bradyarrhythmia...
2018: Acta Medica Lituanica
https://www.readbyqxmd.com/read/29927973/non-fasting-lipid-profile-determination-in-presumably-healthy-children-impact-on-the-assessment-of-lipid-abnormalities
#6
Lukasz Szternel, Magdalena Krintus, Katarzyna Bergmann, Tadeusz Derezinski, Grazyna Sypniewska
OBJECTIVE: Despite the common use of non-fasting measurements for lipid profile in children it remains unclear as to the extent non-fasting conditions have on laboratory results of lipids measurements. We aimed to assess the impact of non-fasting lipid profile on the occurrence of dyslipidemia in children. MATERIALS AND METHODS: Basic lipid profile including: total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG), as well as small, dense-LDL-C (sd-LDL-C), apolipoprotein AI (ApoAI), apolipoprotein B (ApoB) and lipoprotein(a) [Lp(a)], were measured in 289 presumably healthy children aged 9-11 in both fasting and non-fasting condition...
2018: PloS One
https://www.readbyqxmd.com/read/29927433/-the-role-of-lipid-metabolism-disorders-atypical-isoforms-of-protein-kinase-c-and-mutational-status-of-cytosolic-and-mitochondrial-forms-of-isocitrate-dehydrogenase-in-carcinogenesis-of-glial-tumors
#7
P V Nikitin, A A Potapov, M V Ryzhova, V A Shurkhay, E E Kulikov, E S Zhvanskiy, I A Popov, E N Nikolaev
The relationship between molecular genetic and metabolic disorders is one of the challenges of modern oncology. In this review, we consider lipid metabolism and its changes as one of the factors of oncogenesis of glial tumors. Also, we demonstrate that the genome and the metabolome are interconnected by a large number of links, and the metabolic pathways, during their reorganization, are able to drastically affect the genetic structure of the cell and, in particular, cause its tumor transformation. Our own observations and analysis of the literature data allow us to conclude that mass spectrometry is a highly accurate current method for assessing metabolic disorders at the cellular level...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29926995/prevalence-of-combined-and-noncombined-dyslipidemia-in-an-iranian-population
#8
Susan Darroudi, Maryam Saberi-Karimian, Maryam Tayefi, Soheil Arekhi, Ali Motamedzadeh Torghabeh, Seyed Mohammad Reza Seyedzadeh Sani, Mohsen Moohebati, Alireza Heidari-Bakavoli, Mahmoud Ebrahimi, Mahmoud Reza Azarpajouh, Mohammad Safarian, Gordon A Ferns, Habibollah Esmaeili, Mohammad Reza Parizadeh, Naghme Mokhber, Adeleh Mahdizadeh, Ali Asghar Mahmoudi, Amir Hossein Sahebkar, Majid Ghayour-Mobarhan
BACKGROUND: Combination of dyslipidemic phenotypes, including elevated plasma levels of low-density lipoprotein cholesterol (LDL-C), elevated plasma triglycerides (TG), and decreased low-density lipoprotein cholesterol (HDL-C) concentrations, is important because of the association of individual phenotypes with increased risk of cardiovascular disease (CVD). We investigated the prevalence of combined dyslipidemias and their effects on CVD risk in an Iranian large population. METHOD: A total of 9847 individuals were recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study...
June 21, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29926945/non-plaque-induced-gingival-diseases
#9
Palle Holmstrup, Jacqueline Plemons, Joerg Meyle
While plaque-induced gingivitis is one of the most common human inflammatory diseases, several non-plaque-induced gingival diseases are less common but often of major significance for patients. The non-plaque-induced gingival lesions are often manifestations of systemic conditions, but they may also represent pathologic changes limited to gingival tissues. A classification is proposed, based on the etiology of the lesions and includes: Genetic/Developmental disorders; Specific infections; Inflammatory and immune conditions and lesions; Reactive processes; Neoplasms; Endocrine, Nutritional and metabolic diseases; Traumatic lesions; and Gingival pigmentation...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926941/manifestations-of-systemic-diseases-and-conditions-that-affect-the-periodontal-attachment-apparatus-case-definitions-and-diagnostic-considerations
#10
Jasim M Albandar, Cristiano Susin, Francis J Hughes
OBJECTIVES: This review proposes case definitions and diagnostic considerations of systemic disorders and conditions that affect the periodontal attachment apparatus. IMPORTANCE: Periodontal diseases and certain systemic disorders share similar genetic and/or environmental etiological factors, and affected patients may show manifestations of both diseases. Characterizing these diseases and the nature of the association between them could have important diagnostic value and therapeutic implications for patients...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926497/non-plaque-induced-gingival-diseases
#11
Palle Holmstrup, Jacqueline Plemons, Joerg Meyle
While plaque-induced gingivitis is one of the most common human inflammatory diseases, several non-plaque-induced gingival diseases are less common but often of major significance for patients. The non-plaque-induced gingival lesions are often manifestations of systemic conditions, but they may also represent pathologic changes limited to gingival tissues. A classification is proposed, based on the etiology of the lesions and includes: Genetic/Developmental disorders; Specific infections; Inflammatory and immune conditions and lesions; Reactive processes; Neoplasms; Endocrine, Nutritional and metabolic diseases; Traumatic lesions; and Gingival pigmentation...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29926486/manifestations-of-systemic-diseases-and-conditions-that-affect-the-periodontal-attachment-apparatus-case-definitions-and-diagnostic-considerations
#12
Jasim M Albandar, Cristiano Susin, Francis J Hughes
OBJECTIVES: This review proposes case definitions and diagnostic considerations of systemic disorders and conditions that affect the periodontal attachment apparatus. IMPORTANCE: Periodontal diseases and certain systemic disorders share similar genetic and/or environmental etiological factors, and affected patients may show manifestations of both diseases. Characterizing these diseases and the nature of the association between them could have important diagnostic value and therapeutic implications for patients...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29926355/identification-of-proteins-differentially-expressed-by-quercetin-treatment-in-a-middle-cerebral-artery-occlusion-model-a-proteomics-approach
#13
Fawad-Ali Shah, Dong-Ju Park, Phil-Ok Koh
Cerebral ischemia is a major cause of death and neurological disability. It also leads to severe brain tissue damage by excessive generation of oxidative stress. Quercetin is a bioflavonoid substance that acts an antioxidant agent and exerts a neuroprotective effect against cerebral ischemia. The aim of this study was to detect specific proteins that are differentially expressed in response to quercetin treatment in focal cerebral ischemia. Adult male rats were intraperitoneally injected with vehicle or quercetin (10 mg/kg) 30 min prior to right middle cerebral artery occlusion (MCAO)...
June 20, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29926074/-research-advance-in-the-effects-of-androgen-and-its-receptor-on-the-development-of-obesity-obesity-related-diseases-and-disorders-of-glucose-and-lipid-metabolism
#14
Li-Jun Yin, Xiao-Hui Wang
Recently, there has been a growing interest in the roles of androgen in the development of obesity and obesity-related diseases such as diabetes, metabolic syndrome, atherosclerosis (AS), hypertension and cardiovascular diseases, as well as in the disorders of glucose and lipid metabolism. Androgen exerts its biological role mainly through binding to the androgen receptor (AR), one of the nuclear receptors widely expressed in multiple tissues such as the skeletal muscle, liver, adipose tissue and brain. Low testosterone and AR deficiency result in obesity, obesity-related diseases and metabolic disorders...
June 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29926073/-research-advances-in-the-regulation-of-cardiovascular-metabolic-disorders-and-its-related-risk-factors-by-c1q-tnf-related-proteins
#15
Shi-Han Zhang, Yun-Hui DU, Hai-Cun Yu, Yu-Ming Li, Hui-Rong Liu
The complement C1q/TNF related protein (CTRP) family is rapidly growing and currently comprises 15 members. Although CTRP proteins share a common structure composed of four distinct domains: a signal peptide at the N terminus, a short variable region, a collagenous domain, and a C-terminal globular domain, which is homologous to adiponectin, each CTRP has a unique tissue expression profile and varied function. In this review we focus on the biochemistry and pleiotropic functions of CTRPs as new molecular mediators regulating cardiovascular metabolic disorders and its related risk factors diseases...
June 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29925861/the-homeostasis-maintaining-metabolites-from-bacterial-stress-response-to-bacteriophage-infection-suppress-tumor-metastasis
#16
Tianliang He, Min Jin, Chenxi Xu, Zhongjun Ma, Fufang Wu, Xiaobo Zhang
The antiviral metabolites from bacterial stress response to bacteriophage infection can maintain homeostasis of host cells, while metabolism disorder is a remarkable characteristic of tumorigenesis. In the aspect of metabolic homeostasis, therefore, the antiviral homeostasis-maintaining metabolites of bacteria may possess anti-tumor activity. However, this issue has not been addressed. Here we show that the homeostasis-challenged maintaining metabolites from deep-sea bacteriophage-challenged thermophile can suppress tumor metastasis...
June 20, 2018: Oncogene
https://www.readbyqxmd.com/read/29925776/yeast-based-screen-to-identify-natural-compounds-with-a-potential-therapeutic-effect-in-hailey-hailey-disease
#17
Graziella Ficociello, Azzurra Zonfrilli, Samantha Cialfi, Claudio Talora, Daniela Uccelletti
The term orthodisease defines human disorders in which the pathogenic gene has orthologs in model organism genomes. Yeasts have been instrumental for gaining insights into the molecular basis of many human disorders, particularly those resulting from impaired cellular metabolism. We and others have used yeasts as a model system to study the molecular basis of Hailey-Hailey disease (HHD), a human blistering skin disorder caused by haploinsufficiency of the gene ATP2C1 the orthologous of the yeast gene PMR1 ...
June 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29925774/dietary-supplementation-with-a-magnesium-rich-marine-mineral-blend-enhances-the-diversity-of-gastrointestinal-microbiota
#18
Erin K Crowley, Caitriona M Long-Smith, Amy Murphy, Elaine Patterson, Kiera Murphy, Denise M O'Gorman, Catherine Stanton, Yvonne M Nolan
Accumulating evidence demonstrates that dietary supplementation with functional food ingredients play a role in systemic and brain health as well as in healthy ageing. Conversely, deficiencies in calcium and magnesium as a result of the increasing prevalence of a high fat/high sugar "Western diet" have been associated with health problems such as obesity, inflammatory bowel diseases, and cardiovascular diseases, as well as metabolic, immune, and psychiatric disorders. It is now recognized that modulating the diversity of gut microbiota, the population of intestinal bacteria, through dietary intervention can significantly impact upon gut health as well as systemic and brain health...
June 20, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29925739/-treatment-of-mandibular-fracture-associated-infectious-pseudarthrosis-accompanied-by-osteomyelitis-in-a-peritoneal-dialysis-patient
#19
Soichi Hirashima, Akihiko Miyawaki, Kotaro Oho, Yawaka Shitozawa, Motohiro Arai, Norihiko Furuta, Ryoichi Oya
Peritoneal dialysis can be performed at home, and the transfer of solutes in the blood and other body fluids is slow compared to hemodialysis, reducing the load on the circulatory organs and lessening the frequency of hospital visits. We encountered a male patient in his 70s on peritoneal dialysis for end-stage renal failure who developed obsolete mandibular fracture-associated pseudarthrosis accompanied by osteomyelitis, which was treated with noninvasive reduction and fixation using circumferential wiring after the resolution of inflammation...
2018: Journal of UOEH
https://www.readbyqxmd.com/read/29925546/vitamin-d-and-risk-of-pregnancy-related-hypertensive-disorders-mendelian-randomisation-study
#20
Maria C Magnus, Kozeta Miliku, Anna Bauer, Stephanie M Engel, Janine F Felix, Vincent W V Jaddoe, Debbie A Lawlor, Stephanie J London, Per Magnus, Ralph McGinnis, Wenche Nystad, Christian M Page, Fernando Rivadeneira, Lars C Stene, German Tapia, Nicholas Williams, Carolina Bonilla, Abigail Fraser
OBJECTIVE: To use mendelian randomisation to investigate whether 25-hydroxyvitamin D concentration has a causal effect on gestational hypertension or pre-eclampsia. DESIGN: One and two sample mendelian randomisation analyses. SETTING: Two European pregnancy cohorts (Avon Longitudinal Study of Parents and Children, and Generation R Study), and two case-control studies (subgroup nested within the Norwegian Mother and Child Cohort Study, and the UK Genetics of Pre-eclampsia Study)...
June 20, 2018: BMJ: British Medical Journal
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