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https://www.readbyqxmd.com/read/28643947/effect-of-tet1-regulating-mgmt-on-chemotherapy-resistance-of-oral-squamous-cell-carcinoma-stem-cells
#1
Wei Wang, Xin Li, Fan Wang, Xiang-Yu Sun
The study was to evaluate the effect of ten-eleven translocation 1 (TET1) regulating o6-methylguanine-DNA methyltransferase (MGMT) in chemotherapy resistance of oral squamous cell carcinoma (OSCC) stem cells. OSCC stem cells were divided into the blank, negative control (NC), TET1-siRNA, TET1-siRNA + MGMT-OE and MGMT-OE groups. Methylation-specific polymerase chain reaction (MSP), qRT-PCR and western blotting were conducted to detect the methylation status of MGMT, expressions of TET1, MGMT, ABCG2 and Oct-4...
June 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28637016/socs1-gene-promoter-methylation-status-is-associated-with-in-stent-restenosis-after-percutaneous-coronary-intervention
#2
Liang Zhou, Ningfu Wang, Hong Li, Guoxin Tong, Jianmin Yang, Lei Lai, Hao Pan, Xianhua Ye, Jinyu Huang
BACKGROUND: Inflammation is involved in the development of In-stent restenosis (ISR) after percutaneous coronary intervention. We aimed to investigate the association between of suppressor of cytokine signaling-1 (SOCS1), a major negative regulator for inflammation, and the occurrence of ISR in Chinese patients. METHODS: We enrolled patients with coronary artery disease who underwent PCI with stenting. PCI procedures were performed successfully and a follow-up angiography was repeated 1 year later to determine ISR presence...
June 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28634272/the-secreted-msp-domain-of-c-elegans-vapb-homolog-vpr-1-patterns-the-adult-striated-muscle-mitochondrial-reticulum-via-smn-1
#3
Jessica Schultz, Se-Jin Lee, Tim Cole, Hieu D Hoang, Jack Vibbert, Pauline A Cottee, Michael A Miller, Sung Min Han
The major sperm protein domain (MSPd) has an extracellular signaling function implicated in amyotrophic lateral sclerosis. Secreted MSPds derived from the C. elegans VAPB homolog VPR-1 promote mitochondrial localization to actin-rich I-bands in body wall muscle. Here we show that the nervous system and germ line are key MSPd secretion tissues. MSPd signals are transduced through the CLR-1 Lar-like tyrosine phosphatase receptor. We show that CLR-1 is expressed throughout the muscle plasma membrane, where it is accessible to MSPd within the pseudocoelomic fluid...
June 15, 2017: Development
https://www.readbyqxmd.com/read/28634105/genetic-diversity-in-the-c-terminus-of-merozoite-surface-protein-1-among-plasmodium-knowlesi-isolates-from-selangor-and-sabah-borneo-malaysia
#4
Nan Jiun Yap, Xiang Ting Goh, Anson V Koehler, Timothy William, Tsin Wen Yeo, Indra Vythilingam, Robin B Gasser, Yvonne A L Lim
Plasmodium knowlesi, a malaria parasite of macaques, has emerged as an important parasite of humans. Despite the significance of P. knowlesi malaria in parts of Southeast Asia, very little is known about the genetic variation in this parasite. Our aim here was to explore sequence variation in a molecule called the 42kDa merozoite surface protein-1 (MSP-1), which is found on the surface of blood stages of Plasmodium spp. and plays a key role in erythrocyte invasion. Several studies of P. falciparum have reported that the C-terminus (a 42kDa fragment) of merozoite surface protein-1 (MSP-142; consisting of MSP-119 and MSP-133) is a potential candidate for a malaria vaccine...
June 17, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28606809/animal-derived-natural-products-used-in-the-bhutanese-sowa-riga-medicine
#5
Karma Yeshi, Paolo Morisco, Phurpa Wangchuk
ETHNOPHARMACOLOGICAL RELEVANCE: Bhutan has two traditional healing systems: a folklore medicine and the Bhutanese Sowa Rigpa medicine (BSM). Three different types of ingredients namely plants, animals (and their derived products) and minerals are used for the preparation of various formulations in combined form. Animals and their derived products are vital ingredients in the preparation of numerous traditional remedies. Unlike medicinal plants, research on medicinal animals has remained largely untouched...
June 9, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28598118/-the-evaluation-value-of-methylation-status-of-cpg-island-of-sfrp1-and-line1-gene-promoter-area-in-the-prognosis-of-hepatocellular-carcinoma
#6
Yuan Huang, Ling Wei, Ai-Min Sun, Rong-Ce Zhao, Jing Zhang, Han-Teng Yang, Bo Li, Cheng-Jun Sun, Xue-Qin Ding, Bo Gao, Yan-Qin Zhong, Yang Qin
OBJECTIVES: To investigate the relationship between aberrant promoter CpG islands methylation status of secreted frizzled related protein 1 (SFRP1) and long intersper sed nuclear element 1 (LINE1) gene and clinicopathologic parameters to determine their prognosis value for hepatocellular carcinoma (HCC). METHODS: 105 cases of HCC and 50 cases of normal people plasma were collected,and then the promoter hypermethylation status of SFRP1 and hypormethylation status of LINE1 were examined by methylation specific PCR (MSP); The relationship between SFRP1/LINE1 methylation status and patients' clinicopathologic factors was analyzed;The association between SFRP1/LINE1 methylation status and disease-free survival and overall survival was analyzed by Kaplan-Meier curves,the log-rank test,and multivariate Cox regression...
November 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28598109/-the-study-of-decitabine-effect-on-the-endometrial-carcinoma-xenografted-in-nude-mice
#7
Ran-Hong Li, Xue-Ping Wang, Hui Liu
OBJECTIVES: To explore the effect of the demethylation drug 5-Aza-CdR on endometrial carcinoma xenografted in nude mice. METHODS: Randomly assigned the mice into decitabine (AZA),cisplatin (DDP),medroxyprogesterone acetate (MPA),AZA+DDP,AZA+MPA,DDP+MPA and model groups (three in each group) after building the models of xenografted tumor by transplanting the HEC-1B cells on nude mice,and dealt them respectively with corresponding drugs (1 μg/g,single or combination) in the experiment groups and normal saline in model group (injected per 3 d,8 injections in total)...
November 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28592127/methylation-of-sox1-and-vim-promoters-in-serum-as-potential-biomarkers-for-hepatocellular-carcinoma
#8
X Y Liu, Y C Fan, S Gao, J Zhao, L Y Chen, F Li, K Wang
Aberrant methylation of tumor-related genes has been identified as a promising biomarker for hepatocellular carcinoma (HCC). This study aimed to investigate the diagnostic value of SRY (sex determining region Y)-box 1 (SOX1) and Vimentin (VIM) promoter methylation for HCC. The study included 360 subjects, 240 patients with HCC, 29 with liver cirrhosis (LC), 66 with chronic hepatitis B (CHB) and 25 healthy controls (HCs). The methylation status of SOX1 and VIM promoters in the serum was detected by methylation-specific polymerase chain reaction (MSP)...
June 8, 2017: Neoplasma
https://www.readbyqxmd.com/read/28586056/microrna-497-acts-as-a-tumor-suppressor-in-gastric-cancer-and-is-downregulated-by-dna-methylation
#9
Jichao Liu, Yongshuang Li, Ying Zou, Jiakui Zhang, Jiaxiang An, Jiao Guo, Minghui Ma, Dongqiu Dai
Gastric cancer (GC) is one of the most common malignant tumors in the world and microRNAs (miRNAs) play an important role in GC. In this study, we found miR‑497 played an important role and served as a novel biomarker in GC. Quantitative real-time PCR (qRT-PCR) was used to measure the miR‑497 expression in GC cell lines and 86 paired GC samples and we also analyzed its correlation with GC clinicopathological parameters. A series of cellular function experiments were applied to validate the effects of miR‑497 on GC...
June 6, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28576864/lin-41-and-oma-ribonucleoprotein-complexes-mediate-a-translational-repression-to-activation-switch-controlling-oocyte-meiotic-maturation-and-the-oocyte-to-embryo-transition-in-caenorhabditis-elegans
#10
Tatsuya Tsukamoto, Micah D Gearhart, Caroline A Spike, Gabriela Huelgas-Morales, Makaela Mews, Peter R Boag, Traude H Beilharz, David Greenstein
An extended meiotic prophase is a hallmark of oogenesis. Hormonal signaling activates the CDK1/cyclin B kinase to promote oocyte meiotic maturation, which involves nuclear and cytoplasmic events. Nuclear maturation encompasses nuclear envelope breakdown, meiotic spindle assembly, and chromosome segregation. Cytoplasmic maturation involves major changes in oocyte protein translation and cytoplasmic organelles and is poorly understood. In the nematode Caenorhabditis elegans, sperm release the major sperm protein (MSP) hormone to promote oocyte growth and meiotic maturation...
June 1, 2017: Genetics
https://www.readbyqxmd.com/read/28554048/ascorbic-acid-mediated-enhanced-cardiomyocyte-differentiation-of-mouse-es-cells-involves-interplay-of-dna-methylation-and-multiple-signals
#11
Deepti Abbey, Polani B Seshagiri
Embryonic stem cells (ES-cells) provide a good model system to study lineage-specific differentiation. Though, the differentiation of ES-cells to cardiomyocytes is documented, a clear understanding of the molecular mechanism of differentiation and improved functional-differentiation efficiency are yet to be achieved. In this regard, ascorbic acid (Aa) is shown to be one of the effective cardiac inducers in ES-cells. But, its mechanism is poorly understood. We therefore, investigated the mechanism of Aa-mediated cardiomyocyte differentiation of ES-cells...
May 10, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/28549390/clinical-and-molecular-monitoring-of-plasmodium-falciparum-resistance-to-antimalarial-drug-artesunate-sulphadoxine-pyrimethamine-in-two-highly-malarious-district-of-madhya-pradesh-central-india-from-2012-2014
#12
Sweta Mishra, Praveen K Bharti, Man M Shukla, Nazia A Ali, Sher S Kashyotia, Avdhesh Kumar, Akshay C Dhariwal, Neeru Singh
The spread of P. falciparum resistant strain has led to a significant resurgence of malaria morbidity and mortality. The current cornerstone in malaria treatment in India is Artemisinin based Combination (Artesunate + Sulphadoxine-Pyrimethamine) Therapy (ACT) for treatment of uncomplicated P. falciparum malaria since 2010. In the present study we assessed the therapeutic efficacy of ACT and molecular monitoring of antimalarial resistance. Therapeutic efficacy was determined by in vivo method using 28 days follow-up...
May 26, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28506038/pcr-rflp-for-rapid-subtyping-of-plasmodium-vivax-korean-isolates
#13
Jung-Mi Kang, Jinyoung Lee, Tae Im Kim, Eun-Ha Koh, Tong-Soo Kim, Woon-Mok Sohn, Byoung-Kuk Na
Vivax malaria reemerged in Korea in 1993 and the outbreak has been continued with fluctuating numbers of annual indigenous cases. Understanding the nature of the genetic population of Plasmodium vivax circulating in Korea is beneficial for the knowledge of the nationwide parasite heterogeneity and in the implementation of malaria control programs in the country. Previously, we analyzed polymorphic nature of merozoite surface protein-1 (MSP-1) and MSP-3α in Korean P. vivax population and identified the Korean P...
April 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28500887/integrated-techno-economic-and-environmental-analysis-of-butadiene-production-from-biomass
#14
Somayeh Farzad, Mohsen Ali Mandegari, Johann F Görgens
In this study, lignocellulose biorefineries annexed to a typical sugar mill were investigated to produce either ethanol (EtOH) or 1,3-butadiene (BD), utilizing bagasse and trash as feedstock. Aspen simulation of the scenarios were developed and evaluated in terms of economic and environmental performance. The minimum selling prices (MSPs) for bio-based BD and EtOH production were 2.9-3.3 and 1.26-1.38-fold higher than market prices, respectively. Based on the sensitivity analysis results, capital investment, Internal Rate of Return and extension of annual operating time had the greatest impact on the MSP...
September 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28488112/work-characteristics-predict-the-development-of-multi-site-musculoskeletal-pain
#15
Jodi Oakman, Astrid de Wind, Swenne G van den Heuvel, Allard J van der Beek
PURPOSE: Musculoskeletal pain in more than one body region is common and a barrier to sustaining employment. We aimed to examine whether work characteristics predict the development of multi-site pain (MSP), and to determine differences in work-related predictors between age groups. METHODS: This study is based on 5136 employees from the Study on Transitions in Employment, Ability and Motivation (STREAM) who reported no MSP at baseline. Measures included physical, emotional, mental, and psychological job demands, social support and autonomy...
May 9, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28482119/silencing-of-homeobox-a5-gene-in-the-stratum-corneum-of-psoriasis
#16
Yoshimasa Nobeyama, Yoshinori Umezawa, Hidemi Nakagawa
Analysis of psoriatic parakeratotic cells is helpful for understanding the pathogenesis of psoriasis. Methylation analysis can be performed on psoriatic scales, but it is unclear whether genes can be silenced by DNA methylation in psoriatic stratum corneum. The present study was conducted to detect genes silenced in psoriatic stratum corneum. Methylation array analysis with 485,577 probes, quantitative real-time methylation-specific PCR (RT-MSP) and bisulfite sequencing were performed for 30 psoriatic scale samples, 6 fully developed psoriatic skin samples and 12 normal skin samples...
May 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28454348/effects-of-ptcs-on-nonsense-mediated-mrna-decay-are-dependent-on-ptc-location
#17
Heegyum Moon, Xuexiu Zheng, Tiing Jen Loh, Ha Na Jang, Yongchao Liu, Da-Woon Jung, Darren R Williams, Haihong Shen
The récepteur d'origine nantais (RON) gene is a proto-oncogene that is responsible for encoding the human macrophage-stimulating protein (MSP) 1 receptor. MSP activation induces RON-mediated cell dissociation, migration and matrix invasion. Isoforms of RON that exclude exons 5 and 6 encode the RONΔ160 protein, which promotes cell transformation in vitro and tumor metastasis in vivo. Premature termination codons (PTCs) in exons activate the nonsense-mediated mRNA decay (NMD) signaling pathway. The present study demonstrated that PTCs at various locations in the alternative exons 5 and 6 could induce NMD of the majority of the spliced, or partially spliced, isoforms...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453906/oral-treponeme-major-surface-protein-sequence-diversity-and-distributions-within-periodontal-niches
#18
Meng You, Yuki Chan, Donnabella C Lacap-Bugler, Yong-Biao Huo, Wenling Gao, W Keung Leung, Rory M Watt
Treponema denticola and other species (phylotypes) of oral spirochetes are widely-considered to play important etiological roles in periodontitis and other oral infections. The major surface protein (Msp) of T. denticola is directly implicated in several pathological mechanisms. Here, we have analyzed msp sequence diversity across 68 strains of oral phylogroup 1 and 2 treponemes; including reference strains of T. denticola, Treponema putidum, Treponema medium, 'Treponema vincentii', and 'Treponema sinensis'...
April 28, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28442543/effect-of-informal-employment-on-the-relationship-between-psychosocial-work-risk-factors-and-musculoskeletal-pain-in-central-american-workers
#19
David Gimeno Ruiz de Porras, Marianela Rojas Garbanzo, Aurora Aragón, Lino Carmenate-Milián, Fernando G Benavides
INTRODUCTION: The constant increase on the psychosocial demands experienced at work seems to contribute to the increase in health problems such as musculoskeletal pain (MSP). This association may be especially important in low-income and middle-income countries, where there is a large proportion of informal workers among whom there is little research. We analysed the association between psychosocial work risk factors and MSP among formal and informal workers using the First Central American Survey of Working Conditions and Health...
April 25, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28401903/impact-of-metric-and-sample-size-on-determining-malaria-hotspot-boundaries
#20
Gillian H Stresman, Emanuele Giorgi, Amrish Baidjoe, Phil Knight, Wycliffe Odongo, Chrispin Owaga, Shehu Shagari, Euniah Makori, Jennifer Stevenson, Chris Drakeley, Jonathan Cox, Teun Bousema, Peter J Diggle
The spatial heterogeneity of malaria suggests that interventions may be targeted for maximum impact. It is unclear to what extent different metrics lead to consistent delineation of hotspot boundaries. Using data from a large community-based malaria survey in the western Kenyan highlands, we assessed the agreement between a model-based geostatistical (MBG) approach to detect hotspots using Plasmodium falciparum parasite prevalence and serological evidence for exposure. Malaria transmission was widespread and highly heterogeneous with one third of the total population living in hotspots regardless of metric tested...
April 12, 2017: Scientific Reports
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