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https://www.readbyqxmd.com/read/27904696/a-study-on-the-correlation-between-mthfr-promoter-methylation-and-diabetic-nephropathy
#1
Xiao-Hui Yang, Ren-Fang Cao, Yang Yu, Miao Sui, Tao Zhang, Jing-Yi Xu, Xiao-Mei Wang
OBJECTIVE: In order to observe the relationship between MTHFR promoter and DN, the determinations on MTHFR promoter methylation level and expression of HCY from DN patients have been carried out. METHODS: According to the Diabetes diagnosis and classification standard from WHO in 1999, 85 patients with DM diagnosed by Endocrinology and 30 healthy participants from our medical examination center were chosen as control specimen to study in this paper. All this specimen were divided into A, B, C and D four groups , which are corresponding simple diabetes mellitus group (SDM), early diabetic nephropathy group (EDN), clinical diabetic nephropathy group (CDN) and normal control group...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27884059/dna-methylation-analysis-in-rat-kidney-epithelial-cells-exposed-to-3-mcpd-and-glycidol
#2
Mine Senyildiz, Buket Alpertunga, Sibel Ozden
3-Monochloropropane-1,2-diol (3-MCPD) is a well-known food processing contaminant that has been regarded as a rat carcinogen, which is known to induce Leydig-cell and mammary gland tumors in males, as well as kidney tumors in both genders. 3-MCPD is highly suspected to be a non-genotoxic carcinogen. 2,3-Epoxy-1-propanol (glycidol) can be formed via dehalogenation from 3-MCPD. We aimed to investigate the cytotoxic effects of 3-MCPD and glycidol, then to demonstrate the possible epigenetic mechanisms with global and gene-specific DNA methylation in rat kidney epithelial cells (NRK-52E)...
November 24, 2016: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/27882617/heritability-estimates-of-muscle-strength-related-phenotypes-a-systematic-review-and-meta-analysis
#3
H Zempo, E Miyamoto-Mikami, N Kikuchi, N Fuku, M Miyachi, H Murakami
The purpose of this study was to clarify the heritability estimates of human muscle strength-related phenotypes (H(2) -msp). A systematic literature search was conducted using PubMed (through August 22, 2016). Studies reporting the H(2) -msp for healthy subjects in a sedentary state were included. Random-effects models were used to calculate the weighted mean heritability estimates. Moreover, subgroup analyses were performed based on phenotypic categories (eg, grip strength, isotonic strength, jumping ability)...
November 23, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27868305/growth-nutrient-digestibility-ileal-digesta-viscosity-and-energy-metabolizability-of-growing-turkeys-fed-diets-containing-malted-sorghum-sprouts-supplemented-with-enzyme-or-yeast
#4
F O Oke, A O Oso, O O Oduguwa, A V Jegede, K-H Südekum, A O Fafiolu, V Pirgozliev
Growth, apparent nutrient digestibility, ileal digesta viscosity, and energy metabolizability of growing turkeys fed diets containing malted sorghum sprouts (MSP) supplemented with enzyme or yeast were investigated using 120, 28-day-old male turkeys. Six treatments were laid out in a 3 × 2 factorial arrangement of treatments with three dietary inclusion levels of MSP (0, 50, and 100 g/kg) and supplemented with 200 mg/kg yeast (Saccharomyces cerevisiae) or 200 mg/kg of a commercial enzyme. The experiment lasted for the starter (day 28-56) and grower phases (day 57-84) of the birds...
November 21, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27852258/allele-specific-antibodies-to-plasmodium-vivax-merozoite-surface-protein-1-prevalence-and-inverse-relationship-to-haemoglobin-levels-during-infection
#5
Nuno Sepúlveda, Cristiane Guimarães Morais, Luiza Carvalho Mourão, Matheus França Freire, Cor Jesus F Fontes, Marcus Vinícius G Lacerda, Chris J Drakeley, Érika Martins Braga
BACKGROUND: Antigenic polymorphisms are considered as one of the main strategies employed by malaria parasites to escape from the host immune responses after infections. Merozoite surface protein-1 (MSP-1) of Plasmodium vivax, a promising vaccine candidate, is a highly polymorphic protein whose immune recognition is not well understood. METHODS AND RESULTS: The IgG responses to conserved (MSP-119) and polymorphic (block 2 and block 10) epitopes of PvMSP-1 were evaluated in 141 P...
November 16, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27818231/epigenetic-reactivation-of-rassf1a-by-phenethyl-isothiocyanate-peitc-and-promotion-of-apoptosis-in-lncap-cells
#6
Sarandeep S S Boyanapalli, Wenji Li, Francisco Fuentes, Yue Guo, Christina N Ramirez, Ximena-Parades Gonzalez, Douglas Pung, Ah-Ng Tony Kong
Epigenetic silencing of tumor suppressor genes is a phenomenon frequently observed in multiple cancers. Ras-association domain family 1 isoform A (RASSF1A) is a well-characterized tumor suppressor that belongs to the Ras-association domain family. Several studies have demonstrated that hypermethylation of the RASSF1A promoter is frequently observed in lung, prostate, and breast cancers. Phenethyl isothiocyanate (PEITC), a phytochemical abundant in cruciferous vegetables, possesses chemopreventive activities; however, its potential involvement in epigenetic mechanisms remains elusive...
November 3, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27815429/developmental-pathways-of-multisite-musculoskeletal-pain-what-is-the-influence-of-physical-and-psychosocial-working-conditions
#7
Subas Neupane, Päivi Leino-Arjas, Clas-Håkan Nygård, Jodi Oakman, Pekka Virtanen
OBJECTIVE: To investigate the developmental pathways of multisite musculoskeletal pain (MSP) and the effect of physical and psychosocial working conditions on the development of MSP trajectories. METHODS: The study was conducted among food industry workers (N=868) using a longitudinal design. Surveys were conducted every 2 years from 2003 to 2009. The questionnaire covered MSP, physical and psychosocial working conditions (physical strain, environmental factors, repetitive movements, awkward postures; mental strain, team support, leadership, possibility to influence) and work ability...
November 4, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27810449/detection-of-high-grade-prostate-cancer-among-plco-participants-using-a-prespecified-four-kallikrein-marker-panel
#8
Eric H Kim, Gerald L Andriole, E David Crawford, Daniel D Sjoberg, Melissa Assel, Andrew J Vickers, Hans Lilja
PURPOSE: To assess the performance of a four-kallikrein panel, with and without microseminoprotein-beta (MSP), to predict high-grade (Gleason 7+, Gleason Grade Group 2+) prostate cancer (PCa) on biopsy in a multiethnic cohort from the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial. MATERIALS AND METHODS: Levels of free, intact, total prostate-specific antigen (PSA), human kallikrein-2, and MSP were measured blinded to outcome in cryo-preserved serum from men in the intervention arm of PLCO...
October 31, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27805929/genetic-variant-rs3750625-in-the-3-utr-of-adra2a-affects-stress-dependent-acute-pain-severity-after-trauma-and-alters-a-microrna-34a-regulatory-site
#9
Sarah D Linnstaedt, Margaret G Walker, Kyle D Riker, Jennifer E Nyland, JunMei Hu, Catherine Rossi, Robert A Swor, Jeffrey S Jones, Luda Diatchenko, Andrey V Bortsov, David A Peak, Samuel A McLean
α2A adrenergic receptor (α2A-AR) activation has been shown in animal models to play an important role in regulating the balance of acute pain inhibition vs. facilitation after both physical and psychological stress. To our knowledge the influence of genetic variants in the gene encoding α2A-AR, ADRA2A, on acute pain outcomes in humans experiencing traumatic stress has not been assessed. In this study, we tested whether a genetic variant in the 3'UTR of ADRA2A, rs3750625, is associated with acute musculoskeletal pain (MSP) severity following motor vehicle collision (MVC, n = 948) and sexual assault (n = 84), and whether this influence was affected by stress severity...
October 25, 2016: Pain
https://www.readbyqxmd.com/read/27789946/real-time-colorimetric-detection-of-dna-methylation-of-the-pax1-gene-in-cervical-scrapings-for-cervical-cancer-screening-with-thiol-labeled-pcr-primers-and-gold-nanoparticles
#10
Jin Huang, Yu-Ligh Liou, Ya-Nan Kang, Zhi-Rong Tan, Ming-Jing Peng, Hong-Hao Zhou
BACKGROUND: DNA methylation can induce carcinogenesis by silencing key tumor suppressor genes. Analysis of aberrant methylation of tumor suppressor genes can be used as a prognostic and predictive biomarker for cancer. In this study, we propose a colorimetric method for the detection of DNA methylation of the paired box gene 1 (PAX1) gene in cervical scrapings obtained from 42 patients who underwent cervical colposcopic biopsy. METHODS: A thiolated methylation-specific polymerase chain reaction (MSP) primer was used to generate MSP products labeled with the thiol group at one end...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27761802/contribution-of-lats1-and-lats2-promoter-methylation-in-oscc-development
#11
Mohammad Ayoub Rigi Ladiz, Maryam Najafi, Dor Mohammad Kordi-Tamandani
The aberrant DNA methylation of the tumor suppressor genes involved in DNA Damage Response (DDR) signaling and cell cycle regulation may lead to the tumorigenesis. Our purpose here is to analyze the promoter methylation and mRNA expression levels of LATS1 and LATS2 (LATS1/2) genes in OSCC. Promoter methylation status of LATS1/2 genes was evaluated in 70 OSCC paraffin-embedded tissues and 70 normal oral samples, using Methylation Specific PCR (MSP). LATS1/2 mRNA expression profiles were also investigated in 14 OSCC patients and 14 normal samples, using real-time PCR...
October 19, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27757741/methylation-status-of-the-riz1-gene-promoter-in-human-glioma-tissues-and-cell-lines
#12
Chenran Zhang, Wei Meng, Jiajia Wang, Yicheng Lu, Guohan Hu, Liuhua Hu, Jie Ma
Retinoblastoma protein-interacting zinc-finger gene 1 (RIZ1), a strong tumor suppressor, is silenced in many human cancers. Our previous studies showed that RIZ1 expression was negatively correlated with the grade of glioma and was a key predictor of patient survival. Therefore, RIZ1 could be a potential tumor suppressor during glioma pathogenesis, although the mechanism underlying RIZ1 gene inactivation in gliomas is unknown. We investigated the methylation status of the RIZ1 promoter in human glioma tissues and four glioblastoma (GBM) cell lines, and verified the effect of the methyltransferase inhibitor 5-aza-2-deoxycytidine (5-aza-CdR) on RIZ1 transcription and cell proliferation...
October 18, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27754426/methylation-analysis-of-dna-mismatch-repair-genes-using-dna-derived-from-the-peripheral-blood-of-patients-with-endometrial-cancer-epimutation-in-endometrial-carcinogenesis
#13
Takashi Takeda, Kouji Banno, Megumi Yanokura, Masataka Adachi, Moito Iijima, Haruko Kunitomi, Kanako Nakamura, Miho Iida, Yuya Nogami, Kiyoko Umene, Kenta Masuda, Yusuke Kobayashi, Wataru Yamagami, Akira Hirasawa, Eiichiro Tominaga, Nobuyuki Susumu, Daisuke Aoki
Germline mutation of DNA mismatch repair (MMR) genes is a cause of Lynch syndrome. Methylation of MutL homolog 1 (MLH1) and MutS homolog 2 (MSH2) has been detected in peripheral blood cells of patients with colorectal cancer. This methylation is referred to as epimutation. Methylation of these genes has not been studied in an unselected series of endometrial cancer cases. Therefore, we examined methylation of MLH1, MSH2, and MSH6 promoter regions of peripheral blood cells in 206 patients with endometrial cancer using a methylation-specific polymerase chain reaction (MSP)...
October 14, 2016: Genes
https://www.readbyqxmd.com/read/27749469/protective-determinants-of-sickness-absence-among-employees-with-multisite-pain-a-7-year-follow-up
#14
Eija Haukka, Anneli Ojajärvi, Leena Kaila-Kangas, Päivi Leino-Arjas
We identified factors protective of all-cause sickness absence (SA) among subjects with multisite musculoskeletal pain (MSP). The nationally representative source sample comprised 3420 actively working Finns aged 30-55 in year 2000 and alive at follow-up. Pain in 18 body locations was combined into four sites (neck, low back, upper limbs, lower limbs). The baseline prevalence of MSP (pain in ≥ 2 sites) was 32 %. Baseline data on sociodemographic factors, work ability, work, health, and lifestyle were gathered by questionnaire, interview and clinical examination and linked with national registers on all-cause SA (periods lasting ≥10 workdays) for 2002-2008...
October 3, 2016: Pain
https://www.readbyqxmd.com/read/27737665/therapeutic-efficacy-of-artemether-lumefantrine-for-the-treatment-of-uncomplicated-plasmodium-falciparum-malaria-from-three-highly-malarious-states-in-india
#15
Praveen K Bharti, Man M Shukla, Pascal Ringwald, Sri Krishna, Pushpendra P Singh, Ajay Yadav, Sweta Mishra, Usha Gahlot, Jai P Malaiya, Amit Kumar, Shambhu Prasad, Pradeep Baghel, Mohan Singh, Jaiprakash Vadadi, Mrigendra P Singh, Maria Dorina G Bustos, Leonard I Ortega, Eva-Maria Christophel, Sher S Kashyotia, Gagan S Sonal, Neeru Singh
BACKGROUND: Anti-malarial drug resistance continues to be a leading threat to malaria control efforts and calls for continued monitoring of waning efficacy of artemisinin-based combination therapy (ACT). Artesunate + sulfadoxine/pyrimethamine (AS + SP) is used for the treatment of uncomplicated Plasmodium falciparum malaria in India. However, resistance against AS + SP is emerged in northeastern states. Therefore, artemether-lumefantrine (AL) is the recommended first line treatment for falciparum malaria in north eastern states...
October 13, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27721878/increased-incidence-of-breast-cancer-in-postmenopausal-women-with-high-body-mass-index-at-the-modena-screening-program
#16
Federica Sebastiani, Laura Cortesi, Milena Sant, Valeria Lucarini, Claudia Cirilli, Elisabetta De Matteis, Isabella Marchi, Rossella Negri, Ennio Gallo, Massimo Federico
PURPOSE: We conducted a study to evaluate the relationship between body mass index (BMI) and the risk of breast cancer (BC) and outcome in a population of 14,684 women aged 55 to 69 years eligible to participate in the Mammography Screening Program (MSP) in the Province of Modena, Italy. METHODS: The study population was drawn from women who underwent mammography screening between 2004 and 2006 in the Province of Modena. Women were subdivided into obese, overweight, and normal-weight categories according to BMI and followed until July 31, 2010, to evaluate the BC incidence...
September 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/27687509/transient-receptor-potential-vanilloid-4-trpv4-silencing-in-helicobacter-pylori-infected-human-gastric-epithelium
#17
Hiroshi Mihara, Nobuhiro Suzuki, Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Haruka Fujinami, Shinya Kajiura, Ayumu Hosokawa, Toshiro Sugiyama
BACKGROUND: Helicobacter pylori (HP) infection induces methylation silencing of specific genes in gastric epithelium. Various stimuli activate the nonselective cation channel TRPV4, which is expressed in gastric epithelium where it detects mechanical stimuli and promotes ATP release. As CpG islands in TRPV4 are methylated in HP-infected gastric epithelium, we evaluated HP infection-dependent changes in TRPV4 expression in gastric epithelium. MATERIALS AND METHODS: Human gastric biopsy samples, a human gastric cancer cell line (AGS), and a normal gastric epithelial cell line (GES-1) were used to detect TRPV4 mRNA and protein expression by RT-PCR and Western blotting, respectively...
September 30, 2016: Helicobacter
https://www.readbyqxmd.com/read/27686883/patterns-of-sexual-behaviour-and-sexual-healthcare-needs-among-transgender-individuals-in-melbourne-australia-2011-2014
#18
Clare Bellhouse, Sandra Walker, Christopher K Fairley, Lenka A Vodstrcil, Catriona S Bradshaw, Marcus Y Chen, Eric P F Chow
OBJECTIVE: Literature surrounding the healthcare needs of transgender individuals is limited in Australia. This study aimed to investigate the demographic characteristics, risk behaviours and HIV/STI positivity among male-to-female (MTF) and female-to-male (FTM) transgender individuals attending Melbourne Sexual Health Centre (MSHC), Australia, between 2011 and 2014. METHOD: A retrospective cohort analysis for 133 transgender individuals was conducted based on the first visit of individuals to MSHC during the study period...
September 29, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27685843/site-specific-methylation-patterns-of-the-gal-and-galr1-2-genes-in-head-and-neck-cancer-potential-utility-as-biomarkers-for-prognosis
#19
Kiyoshi Misawa, Daiki Mochizuki, Shiori Endo, Masato Mima, Yuki Misawa, Atsushi Imai, Kazuya Shinmura, Takeharu Kanazawa, Thomas E Carey, Hiroyuki Mineta
BACKGROUND: The aim of this study was to evaluate the prognostic value of the promoter methylation status of galanin (GAL) and galanin receptor 1/2 (GALR1/2) by assessing their association with disease-free survival and known prognostic factors in head and neck cancer. METHODS: We generated methylation profiles of GAL and GALR1/2 in tumor samples obtained from 202 patients with head and neck squamous cell carcinoma (HNSCC); these included 43 hypopharynx, 42 larynx, 59 oral cavity, and 58 oropharynx tumor samples...
September 29, 2016: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27671736/plasmodium-falciparum-infection-in-febrile-congolese-children-prevalence-of-clinical-malaria-10-years-after-introduction-of-artemisinin-combination-therapies
#20
Mandingha Kosso Etoka-Beka, Francine Ntoumi, Michael Kombo, Julia Deibert, Pierre Poulain, Christevy Vouvoungui, Simon Charles Kobawila, Felix Koukouikila-Koussounda
OBJECTIVES: To investigate the proportion of malaria infection in febrile children consulting a paediatric hospital in Brazzaville, to determine the prevalence of submicroscopic malaria infection, to characterise Plasmodium falciparum infection and compare the prevalence of uncomplicated P. falciparum malaria according to haemoglobin profiles. METHODS: Blood samples were collected from children aged <10 years with an axillary temperature ≥37.5 °C consulting the paediatric ward of Marien Ngouabi Hospital in Brazzaville...
December 2016: Tropical Medicine & International Health: TM & IH
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