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Tremors in elderly

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https://www.readbyqxmd.com/read/28387681/prevalence-of-prodromal-parkinson-s-disease-as-defined-by-mds-research-criteria-among-elderly-patients-undergoing-colonoscopy
#1
Skorvanek Matej, Ladomirjakova Zuzana, Han Vladimir, Lesko Norbert, Feketeova Eva, Jarcuskova Dominika, Repkova Barbora, Spisak Peter, Urbancikova Zuzana, Vargova Adriana, Gombosova Laura, Zakuciova Maria, Veseliny Eduard, Trebuna Frantisek, Mechirova Eva, Gdovinova Zuzana
BACKGROUND: Gastrointestinal symptoms are a well-recognized and common premotor feature of Parkinson's disease (PD). Moreover, multiple studies have assessed the value of colonic α-synuclein as a potential marker of prodromal PD. Recently, the International Parkinson and Movement Disorders Society (MDS) defined research criteria for prodromal PD. OBJECTIVE: The aim of our study was to test the MDS research criteria in patients undergoing diagnostic colonoscopies as potential candidates for inclusion in prospective trials evaluating colonic biopsies as a potential biomarker of prodromal PD...
April 4, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28385436/influence-of-a-removable-prosthesis-on-oral-health-related-quality-of-life-and-mastication-in-elders-with-parkinson-disease
#2
Giselle R Ribeiro, Camila H Campos, Renata Cunha Matheus Rodrigues Garcia
STATEMENT OF PROBLEM: Parkinson disease (PD) symptoms, such as muscle rigidity, tremors in the lips and tongue, and involuntary mandibular movements, may cause oral health-related problems, mastication difficulties, and denture discomfort because of the difficulty in controlling a prosthesis with the oral musculature. PURPOSE: The purpose of this observational clinical study was to evaluate the influence of oral rehabilitation with a removable prosthesis on oral health-related quality of life (OHRQoL) and masticatory efficiency (ME) in elders with PD...
April 3, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28367776/mild-cognitive-impairment-subtypes-in-a-cohort-of-elderly-essential-tremor-cases
#3
Kathleen Collins, Brittany Rohl, Sarah Morgan, Edward D Huey, Elan D Louis, Stephanie Cosentino
OBJECTIVES: Individuals with essential tremor (ET) exhibit a range of cognitive deficits generally conceptualized as "dysexecutive" or "fronto-subcortical," and thought to reflect disrupted cortico-cerebellar networks. In light of emerging evidence that ET increases risk for Alzheimer's disease (AD), it is critical to more closely examine the nature of specific cognitive deficits in ET, with particular attention to amnestic deficits that may signal early AD. METHODS: We performed a cross-sectional analysis of baseline data from 128 ET cases (age 80...
April 3, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28329183/remote-traumatic-brain-injury-is-associated-with-motor-dysfunction-in-older-military-veterans
#4
Raquel C Gardner, Carrie B Peltz, Kimbra Kenney, Kenneth E Covinsky, Ramon Diaz-Arrastia, Kristine Yaffe
Background: Traumatic brain injury (TBI) has been identified as a risk factor for Parkinson's disease (PD). Motor dysfunction among TBI-exposed elders without PD has not been well characterized. We sought to determine whether remote TBI is a risk factor for motor dysfunction on exam and functionally relevant motor dysfunction in day-to-day life among independently living elders without PD. Methods: This is a cross-sectional cohort study of independently living retired military veterans aged 50 or older with (n = 78) and without (n = 85) prior TBI-all without diagnosed PD...
January 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28319282/stereotactic-radiosurgery-for-essential-tremor-retrospective-analysis-of-a-19-year-experience
#5
Ajay Niranjan, Sudesh S Raju, Ali Kooshkabadi, Edward Monaco, John C Flickinger, L Dade Lunsford
BACKGROUND: Essential Tremor (ET) is a common movement disorder that can be disabling. Initial treatment is in the form of medical therapies. Patients with medically refractory ET seek surgical intervention which include radiofrequency thalamotomy, deep brain stimulation, and radiosurgical thalamotomy. Radiosurgical thalamotomy is a minimally invasive surgical option which is especially valuable for elderly and high surgical risk patients. OBJECTIVE: The purpose of this study was to retrospectively analyze the outcomes of stereotactic radiosurgery for patients suffering from medically refractory essential tremor...
March 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28280880/differences-in-postural-tremor-dynamics-with-age-and-neurological-disease
#6
Steven Morrison, Karl M Newell, Justin J Kavanagh
The overlap of dominant tremor frequencies and similarly amplified tremor observed for Parkinson's disease (PD) and essential tremor (ET) means differentiating between these pathologies is often difficult. As tremor exhibits non-linear properties, employing both linear and non-linear analyses may help distinguish between the tremor dynamics of aging, PD and ET. This study was designed to examine postural tremor in healthy older adults, PD and ET using standard linear and non-linear metrics. Hand and finger postural tremor was recorded in 15 healthy older adults (64 ± 6 years), 15 older individuals with PD (63 ± 6 years), and 10 persons with ET (68 ± 7 years)...
March 9, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28270636/-adult-onset-neuronal-intranuclear-inclusion-disease-in-two-female-siblings
#7
Takeshi Yoshimoto, Kazuhiro Takamatsu, Takashi Kurashige, Jun Sone, Gen Sobue, Masaru Kuriyama
Neuronal intranuclear inclusion disease (NIID) in two adult siblings (both women, aged 76 and 68 years) is reported on here. The elder sister had a resting tremor and bradykinesia at age 66 years, and treatment with L-DOPA was initiated(L-3, 4-dihydroxyphenylalanine). Three years later, she showed a frozen gait that was associated with the medication wearing off. The clinical manifestations did not improve with the administration of antiparkinson drugs. Six years later, she showed impaired cognitive functions, which had occured gradually, and she began to take donepezil...
March 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28261780/cognition-in-non-demented-parkinson-s-disease-vs-essential-tremor-a-population-based-study
#8
Á Sánchez-Ferro, J Benito-León, E D Louis, I Contador, J Hernández-Gallego, V Puertas-Martín, F Bermejo-Pareja
OBJECTIVES: Patients with Parkinson's disease (PD) and essential tremor (ET) have a higher risk of cognitive impairment than age-matched controls. Only a few small studies (11-18 subjects per group) have directly compared the cognitive profile of these conditions. Our aim was to compare the cognitive profile of patients with these two conditions to each other and to healthy individuals in a population-based study of non-demented participants. MATERIALS AND METHODS: This investigation was part of the NEDICES study, a survey of the elderly in which 2438 dementia-free participants underwent a short neuropsychological battery...
March 5, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27711942/reversible-valproic-acid-induced-parkinsonism-and-cognitive-impairment-in-an-elderly-patient-with-bipolar-disorder-i
#9
Sameer Hassamal, Susan Waller, Kimberly Reese, Claudia Testa
Valproic acid (VPA) is approved by the Food and Drug Administration (FDA) for the treatment of manic or mixed episodes associated with bipolar disorder. VPA is also used off-label to treat other conditions in psychiatry such as impulse control disorders, major depression, and posttraumatic stress disorder (PTSD). Although VPA is mostly well-tolerated, common adverse effects include gastrointestinal symptoms (nausea, vomiting, diarrhea), neurological symptoms (sedation, ataxia, tremor), weight gain, and alopecia...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/27538602/heart-rate-variability-to-differentiate-essential-tremor-from-early-stage-tremor-dominant-parkinson-s-disease
#10
Jung Han Yoon, Min Seung Kim, Sun Min Lee, Hyun Jae Kim, Ji Man Hong
BACKGROUND: Essential tremor (ET) and Parkinson's disease (PD) are the most common movement disorders in the elderly, but it is difficult to differentiate ET from early-stage tremor-dominant Parkinson's disease (TDPD). METHODS: We investigated heart rate variability (HRV) in 23 patients with ET, 27 patients with TDPD, and 23 healthy controls. HRV was determined using the RR intervals of a 5-min electrocardiogram recording. Measurements of beat-to-beat RR variability, including time domains [(standard deviation of the normal-to-normal RR interval (SDNN), and the root mean square difference of successive RR intervals (RMSSD)] and frequency domains [low-frequency (LF) and high-frequency (HF) components and total spectral power (TP)], were assessed retrospectively...
September 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27535187/a-case-of-lithium-intoxication-induced-by-an-antihypertensive-angiotensin-1-subtype-specific-angiotensin-ii-receptor-blocker-in-an-elderly-patient-with-bipolar-disorder-and-hypertension
#11
Yuichi Hayashi, Shohei Nishida, Akira Takekoshi, Muneharu Murakami, Megumi Yamada, Akio Kimura, Akio Suzuki, Takashi Inuzuka
Lithium carbonate is considered to be a first-line treatment for bipolar disorder; however, this drug has a narrow therapeutic window, and lithium intoxication is commonly induced by various drugs interaction and situations. We herein report a case of lithium intoxication induced by the administration of an antihypertensive agent targeting the angiotensin 1 (AT1) subtype of the angiotensin II receptor in a 65-year-old woman with a 40-year history of bipolar disorder type 1, and 1-year history of essential hypertension...
2016: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/27517671/a-case-of-lithium-induced-parkinsonism-presenting-with-typical-motor-symptoms-of-parkinson-s-disease-in-a-bipolar-patient
#12
Adriana P Hermida, A Umair Janjua, Oliver M Glass, Camille P Vaughan, Felicia Goldstein, Lynn Marie Trotti, Stewart A Factor
Lithium is a mood stabilizer rarely associated with drug-induced parkinsonism (DIP). We present a case of an elderly woman with bipolar disorder who developed parkinsonian symptoms after chronic lithium administration despite therapeutic serum levels. Upon evaluation, classic parkinsonian signs of muscle rigidity, tremor, bradykinesia, freezing of gait, and cognitive decline were observed. Initially, she was diagnosed with Parkinson's disease (PD); however, DaTscan SPECT imaging clarified the diagnosis as DIP...
December 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27494146/benefits-of-subthalamic-stimulation-for-elderly-parkinsonian-patients-aged-70-years-or-older
#13
Shang-Ming Chiou
OBJECTIVES: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an accepted treatment for advanced Parkinson disease (PD). However, there is general reluctance in considering this therapy for PD patients over age 70 years with limited supporting evidence. Present study investigates age impacts in STN-DBS outcomes, focusing particularly on the elderly patients. PATIENTS AND METHODS: Seventy-two consecutive patients were divided into younger and elderly (n=16, cutoff age=70years) groups...
October 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27486710/genetics-of-parkinson-s-disease-a-review-of-snca-and-lrrk2
#14
REVIEW
Takuya Konno, Joanna Siuda, Zbigniew K Wszolek
Parkinson's disease (PD) is a common neurodegenerative disorder that usually affects the elderly. Resting tremor, rigidity, bradykinesia, and postural instability are the main symptoms of PD. The loss of dopaminergic neurons in the substantia nigra and Lewy bodies in remaining neurons are pathological characteristics of PD. To combat these symptoms, dopaminergic therapy can benefit PD patients; however, it is only symptomatic therapy. Although the pathogenesis of PD has yet to be elucidated, approximately 10% of PD patients have familial history of PD...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27477579/an-elderly-man-with-progressive-ataxia-and-palatal-tremor-presenting-with-dizziness-and-oculopalatal-tremor
#15
Yuka Tsukahara, Keisuke Suzuki, Norito Kokubun, Toshiki Nakamura, Hidehiro Takekawa, Koichi Hirata
A 74-year-old man was referred to our department for dizziness and progressive unsteady gait over 6 years. His family history was unremarkable. Neurological examination showed dysarthria, saccadic eye movement, palatal tremor (1.7 Hz)-synchronous with rotational ocular movement, and truncal ataxia. T2-weighted magnetic resonance imaging (MRI) of the brain revealed hyperintense and hypertrophic bilateral inferior olivary nuclei at the medulla and mild cerebellar atrophy. On the basis of neurological findings of oculopalatal tremor and cerebellar ataxia with brain MRI findings, the diagnosis of progressive ataxia and palatal tremor (PAPT) was made...
August 31, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27444659/infusion-treatments-and-deep-brain-stimulation-in-parkinson-s-disease-the-role-of-nursing
#16
Anna De Rosa, Alessandro Tessitore, Leonilda Bilo, Silvio Peluso, Giuseppe De Michele
Parkinson's Disease (PD) represents one of the most common neurodegenerative disorders in the elderly. PD is caused by a loss of dopaminergic cells in the substantia nigra pars compacta. The motor cardinal signs include a resting tremor, bradykinesia, rigidity and postural reflex impairment. Although levodopa represents the gold standard also in the advanced stage of the disease, over the years most patients develop disabling motor fluctuations, dyskinesias, and non-motor complications, which are difficult to manage...
November 2016: Geriatric Nursing
https://www.readbyqxmd.com/read/27037047/lithium-use-in-older-adults-is-associated-with-increased-prescribing-of-parkinson-medications
#17
COMPARATIVE STUDY
Connie Marras, Nathan Herrmann, Hadas D Fischer, Kinwah Fung, Andrea Gruneir, Paula A Rochon, Soham Rej, Simone Vigod, Dallas Seitz, Kenneth I Shulman
OBJECTIVE: To test the hypothesis of an increased incidence of antiparkinson drug prescribing or Parkinson disease (PD) diagnostic codes after chronic lithium treatment compared with chronic valproic acid or antidepressant treatment among older adults. METHODS: A retrospective cohort study using healthcare administrative databases in Ontario, Canada included 1,749 lithium users, 1,787 valproic acid users, and 285,154 other antidepressant users ≥ 66 years old having used the drug continuously in monotherapy for at least 1 year...
April 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/26944110/longitudinal-course-of-mild-parkinsonian-signs-in-elderly-people-a-population-based-study-in-japan
#18
Kenji Wada-Isoe, Kenichiro Tanaka, Yusuke Uemura, Satoko Nakashita, Yuki Tajiri, Shugo Tagashira, Mikie Yamamoto, Mika Yamawaki, Masafumi Kishi, Kenji Nakashima
We aimed to clarify the longitudinal course of mild parkinsonian signs (MPS) and their association with dementia and functional disability by conducting a comprehensive epidemiological study, including brain MRI, and assessments of cognition, depression, and sleep, in people aged ≥65years living in Ama-cho. We diagnosed MPS and parkinsonism (PS) using a modified Unified Parkinson's Disease Rating Scale. The phase I study was conducted between 2008 and 2010 (n=729) and the phase II between 2011 and 2013 (n=436)...
March 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/26940540/restless-legs-syndrome-in-wilson-s-disease-frequency-characteristics-and-mimics
#19
M C Trindade, T Bittencourt, G Lorenzi-Filho, R C Alves, D C de Andrade, E T Fonoff, E Bor-Seng-Shu, A A Machado, M J Teixeira, E R Barbosa, G G Tribl
OBJECTIVE: To determine characteristics, clinical significance, frequency, and mimics of restless legs syndrome (RLS) in a cohort of Wilson's disease (WD, n = 42/f = 18), compared to healthy, matched controls. MATERIALS AND METHODS: Structured clinical interviews (patients and caregiving family members), repeated neurological examinations (afternoon and presleep), comprehensive laboratory tests, WD-, RLS-, and sleep-specific rating scales, and video-polysomnography...
February 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/26876564/one-pass-deep-brain-stimulation-of-dentato-rubro-thalamic-tract-and-subthalamic-nucleus-for-tremor-dominant-or-equivalent-type-parkinson-s-disease
#20
Volker Arnd Coenen, Michel Rijntjes, Thomas Prokop, Tobias Piroth, Florian Amtage, Horst Urbach, Peter Christoph Reinacher
BACKGROUND: Refractory tremor in tremor-dominant (TD) or equivalent-type (EQT) idiopathic Parkinson's syndrome (IPS) poses the challenge of choosing the best target region to for deep brain stimulation (DBS). While the subthalamic nucleus is typically chosen in younger patients as the target for dopamine-responsive motor symptoms, it is more complicated if tremor does not (fully) respond under trial conditions. In this report, we present the first results from simultaneous bilateral DBS of the DRT (dentato-rubro-thalamic tract) and the subthalamic nucleus (STN) in two elderly patients with EQT and TD IPS and dopamine-refractory tremor...
April 2016: Acta Neurochirurgica
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