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https://www.readbyqxmd.com/read/29226533/the-anthelmintic-drug-niclosamide-and-its-analogues-activate-the-parkinson-s-disease-associated-protein-kinase-pink1
#1
Erica Barini, Ageo Miccoli, Federico Tinarelli, Katie Mulholand, Hachemi Kadri, Farhat Khanim, Laste Stojanovski, Kevin D Read, Kerry Burness, Julian J Blow, Youcef Mehellou, Miratul Muqit
Mutations in PINK1, which impair its catalytic kinase activity, are causal for autosomal recessive early onset Parkinson's disease (PD). Various studies have indicated that the activation of PINK1 could be a useful strategy in treating neurodegenerative diseases such as PD. Herein, we show that the anthelmintic drug niclosamide and its analogues are capable of activating PINK1 in cells via reversible impairment of the mitochondrial membrane potential. Using these compounds, we demonstrate for the first time that the PINK1 pathway is active and detectable in primary neurons...
December 10, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29223371/planning-and-prioritizing-direct-acting-antivirals-treatment-for-hcv-patients-in-countries-with-limited-resources-lessons-from-the-egyptian-experience
#2
Aisha Elsharkawy, Maissa El Raziky, Wafaa El Akel, Kadry El Saeed, Rasha Eletreby, Mohamed Hassany, Manal Hamdy El-Sayed, Khaled Kabil, Sohier A Ismail, Magdy El-Serafy, Ashraf Omar Abdelaziz, Mohamed Kamal Shaker, Ayman Yosry, Wahid Doss, Yehia El Shazly, Gamal Esmat, Imam Waked
BACKGROUND AND AIM: The introduction of direct acting antivirals for HCV in Egypt led to massive treatment uptake to become the largest HCV treatment program worldwide. The aim of this paper is to present the Egyptian experience in planning and prioritizing mass treatment for HCV patients, highlighting the difficulties and limitations of the program as guide to other countries of similar limited resources. METHODS: Baseline data of 337,042 patients who started treatment from October 2014 to March 2016 were grouped into three equal time intervals of 6 months each...
December 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29213085/effective-in-vivo-gene-delivery-with-reduced-toxicity-achieved-by-charge-and-fatty-acid-modified-cell-penetrating-peptide
#3
Kaido Kurrikoff, Kadi-Liis Veiman, Kadri Künnapuu, Elin Madli Peets, Tõnis Lehto, Ly Pärnaste, Piret Arukuusk, Ülo Langel
Non-viral gene delivery systems have gained considerable attention as a promising alternative to viral delivery to treat diseases associated with aberrant gene expression. However, regardless of extensive research, only a little is known about the parameters that underline in vivo use of the nanoparticle-based delivery vectors. The modest efficacy and low safety of non-viral delivery are the two central issues that need to be addressed. We have previously characterized an efficient cell penetrating peptide, PF14, for in vivo applications...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29211691/long-term-monitoring-of-water-treatment-technology-designed-for-radium-removal-removal-efficiencies-and-norm-formation
#4
Liie Hill, Siiri Suursoo, Madis Kiisk, Alar Jantsikene, Nele Nilb, Rein Munter, Enn Realo, Rein Koch, Kaisa Putk, Maria Leier, Taavi Vaasma, Kadri Isakar
A drinking water treatment plant in Viimsi, Estonia, was monitored over three years for iron, manganese, radium-226, radium-228, as well as their daughter nuclides, in order to determine the efficiency of the treatment process, gain an insight into the removal mechanisms and interactions between radium, iron, and manganese, and assess the overall longevity and performance of the technology along with the possible build-up of NORM in the treatment process. During the study, samples were collected from raw water, first and second stage filtrate, consumer water, backwash water and filter materials...
December 6, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29208171/ecological-and-biological-studies-on-five-lined-skink-trachylepis-mabuya-quinquetaeniata-inhabiting-two-different-habitats-in-egypt
#5
Mohamed A M Kadry, Hanan R H Mohamed, Mohamed Hosney
This study was carried out to study the diet type, genetic, morphometric and histological variations between two natural populations of Trachylepis quinquetaeniata inhabiting Abu-Rawash, Embaba, North Giza and Garfas-Senoures, El-Faiyum habitats. In this study, morphometric examination showed that Trachylepis quinquetaeniata is a typically ground-dwelling Skink and seems to be frequently associated with grass and below shrubs. Geographic variation in sexual size dimorphism (SSD) and head size dimorphism (HSD) with greater dimensions in Garfas-Senoures, El-Faiyum compared with Abu-Rawash, Embaba, North Giza might be correlated with spatial food availability and abundance or micro-evolutionary change or phenotypic plasticity...
November 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29206627/promoting-physical-activity-in-copd-insights-from-a-randomized-trial-of-a-web-based-intervention-and-pedometer-use
#6
Emily S Wan, Ana Kantorowski, Diana Homsy, Merilee Teylan, Reema Kadri, Caroline R Richardson, David R Gagnon, Eric Garshick, Marilyn L Moy
RATIONALE: Low physical activity is highly prevalent among COPD patients and is associated with increased healthcare utilization and mortality and reduced HRQL. The addition of a website to pedometer use is effective at increasing physical activity; however, the timeline of change and impact of environmental factors on efficacy is unknown. METHODS: U.S. Veterans with COPD were randomized (1:1) to receive either (1) a pedometer and website which provided goal-setting, feedback, disease-specific education, and an online community forum or (2) pedometer alone for 3 months...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29204500/intraoperative-chlorhexidine-irrigation-to-prevent-infection-in-total-hip-and-knee-arthroplasty
#7
Nicholas B Frisch, Omar M Kadri, Troy Tenbrunsel, Abraham Abdul-Hak, Mossub Qatu, Jason J Davis
Background: Surgical site irrigation during total hip (THA) and total knee (TKA) arthroplasty is a routine practice among orthopaedic surgeons to prevent periprosthetic joint infection. The purpose of this study was to evaluate the effect of chlorhexidine gluconate (CHG) irrigation on infection rates following THA and TKA. Methods: Arthroplasties performed before September 2014 served as controls. THA performed before September 2014 (N = 253) underwent intraoperative irrigation with 0...
December 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/29204257/feature-based-retinal-image-registration-using-d-saddle-feature
#8
Roziana Ramli, Mohd Yamani Idna Idris, Khairunnisa Hasikin, Noor Khairiah A Karim, Ainuddin Wahid Abdul Wahab, Ismail Ahmedy, Fatimah Ahmedy, Nahrizul Adib Kadri, Hamzah Arof
Retinal image registration is important to assist diagnosis and monitor retinal diseases, such as diabetic retinopathy and glaucoma. However, registering retinal images for various registration applications requires the detection and distribution of feature points on the low-quality region that consists of vessels of varying contrast and sizes. A recent feature detector known as Saddle detects feature points on vessels that are poorly distributed and densely positioned on strong contrast vessels. Therefore, we propose a multiresolution difference of Gaussian pyramid with Saddle detector (D-Saddle) to detect feature points on the low-quality region that consists of vessels with varying contrast and sizes...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29185382/in-vitro-antileishmania-activity-of-sesquiterpene-rich-essential-oils-from-nectandra-species
#9
Lauriane Serpa Silva Bosquiroli, Ana Caroline Dos Santos Ferreira, Katyuce Souza Farias, Eduarda Carneiro da Costa, Maria de Fátima Cepa Matos, Mônica Cristina Toffoli Kadri, Yasmin Silva Rizk, Flávio Macedo Alves, Renata Trentin Perdomo, Carlos Alexandre Carollo, Carla Cardozo Pinto de Arruda
CONTEXT: New antileishmanias are needed because of toxicity, high cost and resistance problems associated with available drugs. Nectandra (Lauraceae) produces several classes of compounds but its essential oil has not previously been reported to have antileishmania activity. OBJECTIVE: We evaluated the cytotoxicity and antileishmania activity of essential oils from Nectandra amazonum Nees, N. gardneri Meisn., N. hihua (Ruiz & Pav.) Rohwer and N. megapotamica (Spreng...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29184319/a-comparative-study-of-depression-and-associated-risk-factors-among-elderly-inmates-of-old-age-homes-and-community-of-rajkot-a-gujarati-version-of-the-geriatric-depression-scale-short-form-gds-g
#10
Dipeshkumar D Zalavadiya, Anupam Banerjee, Ankit M Sheth, Matib Rangoonwala, Aarohi Mitra, Amiruddin M Kadri
Background: The prevalence of depression among elderly people varies across different setups such as old age homes (OAHs), community, and medical clinics. Aims: The aim of this study was to compare the epidemiological factors pertaining to depression among elderly residents of OAHs and community, using a new Gujarati version of the Geriatric Depression Scale-Short Form (GDS-G). Settings and Design: A cross-sectional, epidemiological study conducted in an urban setup of Western India...
October 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/29184314/reforming-community-medicine-in-line-with-the-country-s-health-priorities-let-s-make-it-relevant-and-rational
#11
EDITORIAL
A M Kadri
No abstract text is available yet for this article.
October 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/29183716/the-effect-of-total-size-of-lesions-in-multifocal-multicentric-breast-cancer-on-survival
#12
Yusuf Karakas, Omer Dizdar, Sercan Aksoy, Mutlu Hayran, Kadri Altundag
BACKGROUND: In this study, we aimed to assess the prognostic performance of determining the T stage according to the total size of lesions compared with the size of the largest lesion in the breast in patients with multifocal/multicentric (MF/MC) breast cancer. PATIENTS AND METHODS: The charts of the patients with MF/MC breast cancer who were diagnosed between 2003 and 2014 were reviewed. The T stage of MF/MC tumors was determined according to the largest lesion size (Tmax) as well as the sum of the longest diameters of the lesions (Tsum) in the breast...
November 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29180002/melatonin-mitigates-thioacetamide-induced-hepatic-fibrosis-via-antioxidant-activity-and-modulation-of-proinflammatory-cytokines-and-fibrogenic-genes
#13
Mohamed A Lebda, Kadry M Sadek, Tarek K Abouzed, Hossam G Tohamy, Yasser S El-Sayed
AIMS: The potential antifibrotic effects of melatonin against induced hepatic fibrosis were explored. MAIN METHODS: Rats were allocated into four groups: placebo; thioacetamide (TAA) (200mg/kg bwt, i.p twice weekly for two months); melatonin (5mg/kgbwt, i.p daily for a week before TAA and continued for an additional two months); and melatonin plus TAA. Hepatic fibrotic changes were evaluated biochemically and histopathologically. Hepatic oxidative/antioxidative indices were assessed...
November 24, 2017: Life Sciences
https://www.readbyqxmd.com/read/29161980/prognostic-impact-of-cd200-and-cd56-expression-in-adult-acute-lymphoblastic-leukemia-patients
#14
Salah Aref, Emad Azmy, Kadry El-Bakry, Lobna Ibrahim, Mohamed Mabed
BACKGROUND: The aim of the study is to determine the prognostic relevance of CD200/ CD56 expression in adult acute lymphoblastic leukemia patients. METHODS: The expression of CD200 and CD56 by blast cells was assessed by flow cytometry before the start of chemotherapy in 70 B-ALL patients. RESULTS: Positive expression of CD200 was detected in forty-six patients (66%) and CD56 was detected in 7 patients (10%) out of 70 patients, respectively...
November 22, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29148880/does-aspirin-decrease-risk-of-specific-breast-cancer-subtype-in-women-with-diabetes
#15
Kadri Altundag
No abstract text is available yet for this article.
November 17, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29148431/comparative-efficacy-of-hemorrhage-control-of-a-novel-mesoporous-bioactive-glass-versus-two-commercial-hemostats
#16
Sara Pourshahrestani, Nahrizul Adib Bin Kadri, Ehsan Zeimaran, Nicola Gargiulo, Shani Samuel, Sangeetha Vasudevaraj Naveen, Khairunnisa Hasikin, Tunku Kamarul, Mark R Towler
Mesoporous bioactive glass containing 1% Ga2O3 (1%Ga-MBG) is attractive for hemorrhage control because of its surface chemistry which can promote blood-clotting. The present study compares this proprietary inorganic coagulation accelerator with two commercial hemostats, CeloxTM (CX) and QuikClot Advanced Clotting Sponge PlusTM (ACS+). The results indicate that the number of adherent platelets were higher on the 1%Ga-MBG and CX surfaces than ACS+ whereas a greater contact activation was seen on 1%Ga-MBG and ACS+ surfaces than CX...
November 17, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29147805/can-clinical-practice-indicator-relating-to-long-acting-benzodiazepine-use-in-the-elderly-be-easily-generated-in-a-hospital-setting
#17
Badria Kadri, Antonio Teixeira, Christelle Duteil, Annabelle Tan, Hélène Barreteau, Christophe Segouin, Pénélope Troude
BACKGROUND: To improve the appropriate use of long-acting benzodiazepine (la.bzd) prescriptions in the elderly, the Haute Autorité de Santé (HAS) has developed clinical practice indicators (CPI). The alert indicator (AI) evaluates the prevalence of la.bzd prescription among older people. The mastering indicator (MI) corresponds to the prevalence of elderly with a justified, i.e., appropriate, la.bzd prescription among all the elderly with la.bzd prescriptions. OBJECTIVE: The objective of this study was to test the feasibility of routine generation of CPI regarding la...
November 16, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29144828/prognostic-impact-of-cd200-and-cd56-expression-in-pediatric-b-cell-acute-lymphoblastic-leukemia-patients
#18
Salah Aref, Emad Azmy, Kadry El-Bakry, Lobna Ibrahim, Sherin Abdel Aziz
This study aimed to determine the prognostic impact of CD200 and CD56 expression in pediatric B cell acute lymphoblastic leukemia (B-ALL) patients, both of which have been implicated in immune tolerance and previously suggested as independent risk factors. CD200 has a central role in immune tolerance that protects stem cells and other critical tissues from immune damage. The expression of CD200/CD56 in leukemic blasts were assessed in leukemic blasts before chemotherapy in 43 bone marrow (BM) and/or peripheral blood (PB) samples by flow cytometry...
November 16, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29135133/the-link-between-obesity-and-triple-negative-breast-cancer
#19
Kadri Altundag
No abstract text is available yet for this article.
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29135131/risk-factors-for-development-of-breast-cancer-in-premenopausal-women-with-atypical-ductal-hyperplasia-are-more-complicated
#20
Kadri Altundag
No abstract text is available yet for this article.
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
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