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https://www.readbyqxmd.com/read/27905484/independent-control-of-natural-killer-cell-responsiveness-and-homeostasis-at-steady-state-by-cd11c-dendritic-cells
#1
Thuy Thanh Luu, Sridharan Ganesan, Arnika Kathleen Wagner, Dhifaf Sarhan, Stephan Meinke, Natalio Garbi, Günter Hämmerling, Evren Alici, Klas Kärre, Benedict J Chambers, Petter Höglund, Nadir Kadri
During infection and inflammation, dendritic cells (DC) provide priming signals for natural killer (NK) cells via mechanisms distinct from their antigen processing and presentation functions. The influence of DC on resting NK cells, i.e. at steady-state, is less well studied. We here demonstrate that as early as 1 day after DC depletion, NK cells in naïve mice downregulated the NKG2D receptor and showed decreased constitutive phosphorylation of AKT and mTOR. Subsequently, apoptotic NK cells appeared in the spleen concomitant with reduced NK cell numbers...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905280/diagnosis-and-species-discrimination-of-positive-malaria-samples-by-real-time-polymerase-chain-reaction
#2
Esra Atalay Şahar, Muhammet Karakavuk, Hüseyin Can, Şebnem Nergiz, Kadri Gül, Aysu Değirmenci Döşkaya, Yüksel Gürüz, Mert Döşkaya
OBJECTIVE: Malaria is an important tropical disease that is detected in 198 million people and causes 367-755 thousand deaths annually. Recently, the real-time Polymerase Chain Reaction (PCR) technique has enabled quick determination of Plasmodium spp. and species identification in the same assay with a low contamination risk. In the present study, we aimed to use real-time PCR targeting the 18S rRNA gene to diagnose Plasmodium spp. and perform species identification. METHODS: DNA samples of 15 patients with malaria (14 caused by P...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27899854/association-of-neutrophil-to-lymphocyte-ratio-with-the-severity-and-morphology-of-coronary-atherosclerotic-plaques-detected-by-multidetector-computerized-tomography
#3
Ahmet Hakan Ateş, Kudret Aytemir, Duygu Koçyiğit, Muhammed Ulvi Yalcin, Kadri Murat Gürses, Hikmet Yorgun, Uğur Canpolat, Tuncay Hazırolan, Necla Özer
BACKGROUND: Studies have demonstrated a consistent relationship between white blood cell (WBC) counts and coronary artery disease (CAD). The neutrophil/lymphocyte ratio (NLR) has been considered as a potential marker for identifying individuals under risk of CAD and associated events. In this study, we aimed to evaluate whether NLR was associated with the severity and morphology of coronary atherosclerotic plaques shown by multidetector computed tomography (MDCT). METHODS: Our study population consisted of 684 patients who underwent dual-source 64 slice MDCT for the assessment of CAD...
November 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27884568/ykl-40-and-other-indicators-of-inflammation-in-coronary-collateral-development-and-syntax-score
#4
Mehmet Kadri Akboga, Asife Sahinarslan
No abstract text is available yet for this article.
November 18, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27881061/traditional-and-alternative-therapies-for-refractory-angina
#5
Duygu Kocyigit, Kadri Murat Gurses, Muhammed Ulvi Yalcin, Lale Tokgozoglu
Refractory angina (RFA) is an unfavourable condition that is characterized with persistent angina due to reversible myocardial ischaemia in patients with coronary artery disease that remains uncontrollable despite an optimal combination of pharmacological agents and revascularization. Despite significant advances in revascularization techniques and agents used in pharmacological therapy, there is a significant population suffering from RFA and the global prevalence is even increasing. Anti- anginal treatment and secondary risk-factor modification are the traditional approaches for this group of patients...
November 23, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27859105/polyphagy-on-unpredictable-resources-does-not-exclude-host-specialization-insects-feeding-on-mushrooms
#6
Kadri Põldmaa, Ants Kaasik, Toomas Tammaru, Olavi Kurina, Siiri Jürgenstein, Tiit Teder
The degree of ecological specialization plays a crucial role in shaping the structure and functioning of communities. However, comparing specialization within and among groups of organisms is complicated by both methodological issues and conceptual and terminological inconsistencies. Environmental predictability has been considered a key determinant of specialization though empirical evidence is still limited. Fungi and their insect consumers provide a poorly studied but promising system to measure host specialization and test the predictability hypothesis...
October 2016: Ecology
https://www.readbyqxmd.com/read/27857757/does-crossover-innervation-really-affect-the-clinical-outcome-a-comparison-of-outcome-between-unilateral-and-bilateral-digital-nerve-repair
#7
Melike Oruç, Kadri Ozer, Özlem Çolak, Yüksel Kankaya, Uğur Koçer
Digital nerve injuries are the mostly detected nerve injury in the upper extremity. However, since the clinical phenomenon of crossover innervation at some degree from uninjured digital nerve to the injured side occurs after digital nerve injuries is sustained, one could argue that this concept might even result in the overestimation of the outcome of the digital nerve repair. With this knowledge in mind, this study aimed to present novel, pure, focused and valuable clinical data by comparing the outcomes of bilateral and unilateral digital nerve repair...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27855558/diagnostic-evaluation-of-rna-sequencing-for-the-detection-of-genetic-abnormalities-associated-with-ph-like-acute-lymphoblastic-leukemia-all
#8
Kai Lee Yap, Larissa V Furtado, Kazuma Kiyotani, Emily Curran, Wendy Stock, Jennifer L McNeer, Sabah Kadri, Jeremy P Segal, Yusuke Nakamura, Michelle M Le Beau, Sandeep Gurbuxani, Gordana Raca
Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is a molecular subtype of high-risk B-cell ALL characterized by formation of abnormal gene fusions involving tyrosine kinase (TK) and cytokine receptor genes and activation of TK signaling. Because of the diversity of associated genetic changes, the detection of Ph-like ALL cases currently requires multiple cytogenetic and molecular assays; thus, our goal was to develop a consolidated workflow for detecting genetic abnormalities in Ph-like ALL. We found that total and targeted RNA sequencing (RNAseq)-based approach allowed the detection of abnormal fusion transcripts (EBF1-PDGFRB, P2RY8-CRLF2, RCSD1-ABL1, and RCSD1-ABL2)...
November 17, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27849704/24-impact-of-penalties-for-central-line-associated-bloodstream-infections-on-blood-culture-ordering
#9
Sameer Kadri, Samuel Hohmann, Fang Zhang, Naomi O'Grady, Michael Klompas
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27836695/clinical-validation-of-a-next-generation-sequencing-genomic-oncology-panel-via-cross-platform-benchmarking-against-established-amplicon-sequencing-assays
#10
Sabah Kadri, Bradley C Long, Ibro Mujacic, Chao J Zhen, Michelle N Wurst, Shruti Sharma, Nadia McDonald, Nifang Niu, Sonia Benhamed, Jigyasa Tuteja, Tanguy Seiwert, Kevin White, Megan E McNerney, Carrie Fitzpatrick, Y Lynn Wang, Larissa V Furtado, Jeremy P Segal
Next-generation sequencing (NGS) genomic oncology profiling assays have emerged as key drivers of personalized cancer care and translational research. However, validation of these assays to meet strict clinical standards has been historically problematic because of both significant assay complexity and a scarcity of optimal validation samples. Herein, we present the clinical validation of 76 genes from a novel 1212-gene large-scale hybrid capture cancer sequencing assay (University of Chicago Medicine OncoPlus) using full-data comparisons against multiple clinical NGS amplicon-based assays to yield dramatic increases in per-sample data comparison efficiency compared with previously published validations...
November 8, 2016: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/27824336/a-variant-reference-data-set-for-the-africanized-honeybee-apis-mellifera
#11
Samir M Kadri, Brock A Harpur, Ricardo O Orsi, Amro Zayed
The Africanized honeybee (AHB) is a population of Apis mellifera found in the Americas. AHBs originated in 1956 in Rio Clara, Brazil where imported African A. m. scutellata escaped and hybridized with local populations of European A. mellifera. Africanized populations can now be found from Northern Argentina to the Southern United States. AHBs-often referred to as 'Killer Bees'- are a major concern to the beekeeping industry as well as a model for the evolutionary genetics of colony defence. We performed high coverage pooled-resequencing of 360 diploid workers from 30 Brazilian AHB colonies using Illumina Hi-Seq (150 bp PE)...
November 8, 2016: Scientific Data
https://www.readbyqxmd.com/read/27798628/mycobacterium-tuberculosis-lineage-4-comprises-globally-distributed-and-geographically-restricted-sublineages
#12
David Stucki, Daniela Brites, Leïla Jeljeli, Mireia Coscolla, Qingyun Liu, Andrej Trauner, Lukas Fenner, Liliana Rutaihwa, Sonia Borrell, Tao Luo, Qian Gao, Midori Kato-Maeda, Marie Ballif, Matthias Egger, Rita Macedo, Helmi Mardassi, Milagros Moreno, Griselda Tudo Vilanova, Janet Fyfe, Maria Globan, Jackson Thomas, Frances Jamieson, Jennifer L Guthrie, Adwoa Asante-Poku, Dorothy Yeboah-Manu, Eddie Wampande, Willy Ssengooba, Moses Joloba, W Henry Boom, Indira Basu, James Bower, Margarida Saraiva, Sidra E G Vasconcellos, Philip Suffys, Anastasia Koch, Robert Wilkinson, Linda Gail-Bekker, Bijaya Malla, Serej D Ley, Hans-Peter Beck, Bouke C de Jong, Kadri Toit, Elisabeth Sanchez-Padilla, Maryline Bonnet, Ana Gil-Brusola, Matthias Frank, Veronique N Penlap Beng, Kathleen Eisenach, Issam Alani, Perpetual Wangui Ndung'u, Gunturu Revathi, Florian Gehre, Suriya Akter, Francine Ntoumi, Lynsey Stewart-Isherwood, Nyanda E Ntinginya, Andrea Rachow, Michael Hoelscher, Daniela Maria Cirillo, Girts Skenders, Sven Hoffner, Daiva Bakonyte, Petras Stakenas, Roland Diel, Valeriu Crudu, Olga Moldovan, Sahal Al-Hajoj, Larissa Otero, Francesca Barletta, E Jane Carter, Lameck Diero, Philip Supply, Iñaki Comas, Stefan Niemann, Sebastien Gagneux
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists...
October 31, 2016: Nature Genetics
https://www.readbyqxmd.com/read/27780003/tear-production-rate-in-a-mouse-model-of-dry-eye-according-to-the-phenol-red-thread-and-endodontic-absorbent-paper-point-tear-tests
#13
Servet Kilic, Kadri Kulualp
This study compared the endodontic absorbent paper point test (EAPTT) and the phenol red thread test (PRTT) for the assessment of tear production rate in a mouse model of dry eye. Fourteen BALB/c breed female mice were allocated into experimental and control groups of equal number. For 6 wk, the experimental group was kept in dry-eye cabinets, whereas the control group was kept in normal cages under ambient conditions. In both groups, the tear production rate was measured by using EAPTT and PRTT before the study, at study baseline, and at weeks 2, 4, and 6...
2016: Comparative Medicine
https://www.readbyqxmd.com/read/27760833/statin-effect-on-platelet-to-lymphocyte-ratio
#14
Çağri Yayla, Kadriye Gayretli Yayla, Ahmet Göktuğ Ertem, Mehmet Kadri Akboğa, Burak Açar, Sefa Ünal
No abstract text is available yet for this article.
October 19, 2016: Angiology
https://www.readbyqxmd.com/read/27756583/final-results-of-the-randomized-phase-ii-norcap-ca223-trial-comparing-first-line-all-oral-versus-taxane-based-chemotherapy-for%C3%A2-her2-negative-metastatic-breast-cancer
#15
Saverio Cinieri, Arlene Chan, Kadri Altundag, An Vandebroek, Nicole Tubiana-Mathieu, Agusti Barnadas, Patricia Dodyk, Silvia Lazzarelli, Michiel Botha, Daniel Rauch, Gustavo Villanova, Ugur Coskun
BACKGROUND: The purpose of this study was to evaluate the efficacy of 3 first-line chemotherapy combination regimens for HER2-negative metastatic breast cancer (mBC). PATIENTS AND METHODS: In this open-label, 3-arm, randomized phase II trial, patients were randomized to all-oral NORCAP (vinorelbine/capecitabine), GEMPAC (gemcitabine/paclitaxel), or GEMDOC (gemcitabine/docetaxel) as first-line chemotherapy for HER2-negative mBC. Stratification factors were center, previous (neo)adjuvant anthracycline, and age...
June 25, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27756509/the-association-between-body-mass-index-and-immunohistochemical-subtypes-in-breast-cancer
#16
Suleyman Sahin, Gokmen U Erdem, Fatih Karatas, Aydin Aytekin, Ali R Sever, Yavuz Ozisik, Kadri Altundag
BACKGROUND: Body mass index (BMI) is defined as a poor prognostic factor in patients with breast cancer (BC). However, there are controversial results regarding the various effects of BMI on BC, hence the exact pathophysiology of the relation between obesity and BC is still under debate, and remains unclear. This paper aims to investigate the association between BMI at presentation and BC subtypes defined according to the immunohistochemical classification in both premenopausal and postmenopausal patients with BC...
October 15, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27749296/massive-fulminant-thrombosis-during-liver-transplantation-in-a-patient-with-a-previously-unknown-antithrombin-pathway-mutation
#17
Dmitri Bezinover, Shigekazu Sugino, Yuka Imamura-Kawasawa, Matthew S Bell, Zakiyah Kadry, Piotr K Janicki
We describe a case of fulminant intraoperative thrombosis during deceased donor liver transplantation. Despite significant medical bleeding, the patient suddenly developed diffuse thrombosis in all chambers of the heart and pulmonary vasculature resulting in intraoperative death. The patient's postmortem genetic analysis demonstrated a deleterious missense mutation in a coagulation pathway gene, SERPINC1, which codes for antithrombin III. The level of antithrombin III was not available to directly prove the causality of thrombosis, but our findings suggest that this mutation, in combination with antifibrinolytic administration in a hypercoagulable cirrhotic patient, might have contributed to the development of this catastrophic thrombotic event...
December 1, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27746055/the-course-of-cognitive-functioning-after-first-episode-of-psychosis-a-six-month-follow-up-study
#18
Liina Haring, René Mõttus, Kärolin Kajalaid, Kadri Koch, Kärt Uppin, Eduard Maron, Eero Vasar
Our aim with the present study was to evaluate rank-order and mean-level cognitive functioning stability among first-episode psychosis (FEP) patients, measured using the Cambridge Neuropsychological Test Automated Battery (CANTAB), over a six month period. We also aimed to examine longitudinal measurement invariance and identify factors-such as age, gender, educational level, treatment and psychopathological change scores-potentially linked to cognitive change among patients. In addition, correlations between objectively measured and subjectively evaluated cognitive functioning were estimated...
October 13, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27727508/relation-between-lymphocyte-to-monocyte-ratio-and-short-term-mortality-in-patients-with-acute-pulmonary-embolism
#19
Ahmet Goktug Ertem, Cagri Yayla, Burak Acar, Ozgur Kirbas, Sefa Unal, Melahat Uzel Sener, Mehmet Kadri Akboga, Tolga Han Efe, Serkan Sivri, Fatih Sen, Serkan Gokaslan, Serkan Topaloglu
INTRODUCTION: The relationship between inflammation and mortality after acute pulmonary embolism (APE) has previously been investigated with different variables (platelet/lymphocyte ratio, etc). OBJECTIVES: We investigated the predictive value of lymphocyte to monocyte ratio (LMR) for mortality in first 30 days after APE. METHODS: The study population included 264 APE patients of which 230 patients were survivors, 34 patients were non-survivors...
October 11, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27727089/netrin-1-is-associated-with-macrophage-infiltration-and-polarization-in-human-epicardial-adipose-tissue-in-coronary-artery-disease
#20
Kadri Murat Gurses, Fusun Ozmen, Duygu Kocyigit, Nilgun Yersal, Elif Bilgic, Erkan Kaya, Cagla Zubeyde Kopru, Tolga Soyal, Suat Doganci, Lale Tokgozoglu, Petek Korkusuz
BACKGROUND: Inflammatory activity originating from the epicardial adipose tissue (EAT) may have a role in coronary artery disease (CAD) pathogenesis. The relationship between macrophage infiltration, polarization in the EAT, and netrin-1 gene expression was investigated. METHODS: Macrophage infiltration and polarization were examined by immunohistochemical methods and expression levels of netrin-1, Unc5b, and cytokines related with M1-macrophage subtype (IL-12 and IL-18) were determined by quantitative polymerase chain reaction in subcutaneous and epicardial adipose tissue obtained from patients undergoing coronary artery bypass grafting and non-coronary cardiac surgery...
October 7, 2016: Journal of Cardiology
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