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https://www.readbyqxmd.com/read/28453394/expression-of-mir-23a-by-apoptotic-regulators-in-human-cancer-a-review
#1
Rabih Roufayel, Seifedine Kadry
MicroRNAs play fundamental roles in mammalian development, differentiation and cellular homeostasis by regulating essential processes such as proliferation, migration, metabolism, migration and cell death. These small non-coding RNAs are also responsible in RNA silencing, and in many developmental and pathological processes. Not surprisingly, miR-23a misexpression contributes to numerous diseases including cancer where certain miRNA genes have been classified as either oncogenes or tumor suppressor genes. Since a single microRNA is capable of targeting a large number of mRNA sequences, de-regulated miRNA expression has the ability to alter various transcripts and activate a wide range of cancer-related pathways...
April 28, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28440199/anti-hyperglycemic-agents-for-the-treatment-of-type-2-diabetes-mellitus-role-in-cardioprotection-during-the-last-decade
#2
Duygu Kocyigit, Kadri Murat Gurses, Muhammed Ulvi Yalcin, Lale Tokgozoglu
Type 2 diabetic patients are known to have a tendency to develop cardiovascular (CV) disease (CVD), and related unfavourable outcomes such as heart failure, myocardial infarction (MI), cerebrovascular events (eg. stroke), and related mortality. Long- term clinical trials have revealed contradictory findings regarding the relationship between glycemic control and CV benefits due to variations in the key characteristics of the study population. During the last decade, number of pharmacological agents used for glucose- lowering in the treatment of type 2 diabetes mellitus (T2DM) has increased owing to the introduction of dipeptidyl peptidase- IV (DPP- IV) inhibitors, glucagon- like peptide- 1 (GLP- 1) receptor agonists, and sodium-glucose co-transporter 2 (SGLT- 2) inhibitors...
April 23, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28434766/stereoselective-synthesis-of-enantiopure-n-substituted-pyrrolidin-2-5-dione-derivatives-by-1-3-dipolar-cycloaddition-and-assessment-of-their-in-vitro-antioxidant-and-antibacterial-activities
#3
Siwar Ghannay, Sana Bakari, Ameni Ghabi, Adel Kadri, Moncef Msaddek, Kaïss Aouadi
1,3-Dipolar cycloaddition between a chiral nitrone and N-substituted maleimides afforded unprecedented enantiopure spiro-fused heterocycles in good yields with a high enantio- and diastereoselectivity. The reaction was taking place on the less hindered face of the nitrone. The obtaining heterocycles were screened for their in vitro antioxidant properties and the results revealed that the potent antioxidant activity was generally recorded to compounds (3g) and (3e). The in vitro antibacterial activities of these two compounds were also investigated and the results demonstrated the strongest potential of compound (3g) against all the tested bacteria...
April 13, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28429693/predictors-of-neurologically-favorable-survival-among-patients-with-out-of-hospital-cardiac-arrest-a-tertiary-referral-hospital-experience
#4
Kevser Gülcihan Balcı, Mustafa Mücahit Balcı, Fatih Şen, Mehmet Kadri Akboğa, Erol Kalender, Samet Yılmaz, Orhan Maden, Hatice Selçuk, Timur Selçuk, Ahmet Temizhan
OBJECTIVE: Despite recent advances in medical support and interventions, only 5% to 10% of patients with out-of-hospital cardiac arrest (OHCA) survive to discharge. In this study, factors related to neurologically favorable survival in patients with OHCA were analyzed. METHODS: A total of 129 patients who were admitted to hospital with OHCA were retrospectively enrolled. RESULTS: Sustained return of spontaneous circulation (ROSC) (ROSC lasting >20 min) was achieved in 29 (22...
April 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28426135/tlr-stimulated-eosinophils-mediate-recruitment-and-activation-of-nk-cells-in-vivo
#5
Shaunagh M O'Flaherty, Kripitch Sutummaporn, Walina L Häggtoft, Amy P Worrall, Marzia Rizzo, Viorica Braniste, Petter Höglund, Nadir Kadri, Benedict J Chambers
Eosinophils like many myeloid innate immune cells can provide cytokines and chemokines for the activation of other immune cells upon TLR stimulation. When TLR stimulated eosinophils were inoculated i.p. into wildtype mice, NK cells were rapidly recruited and exhibited anti-tumor cytotoxicity. However when mice depleted of CD11c(+) cells were used, a marked decrease in the number of recruited NK cells was observed. We postulated that CpG or LPS from the injected eosinophils could be transferred to host cells, which in turn could recruit NK cells...
April 20, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28424130/invasive-pleomorphic-lobular-histology-is-an-adverse-prognostic-factor-on-survival-in-patients-with-breast-cancer
#6
Suleyman Sahin, Fatih Karatas, Gokmen U Erdem, Bekir Hacioglu, Kadri Altundag
Invasive pleomorphic lobular carcinoma (IPLC) is defined to be an uncommon and different subtype of classical invasive lobular carcinoma (ILC). This special variant is characterized by significant cytological atypia and pleomorphism which differs from the cytological uniformity of ILC. IPLC has been shown to have some poor prognostic factors such as axillary node metastasis and higher histological grade which may lead to poor clinical courses including a short relapse time, increased risk of recurrence and a decreased survival...
April 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28418807/coagulase-negative-staphylococci-in-human-milk-from-mothers-of-preterm-compared-with-term-neonates
#7
Hiie Soeorg, Tuuli Metsvaht, Imbi Eelmäe, Hanna Kadri Metsvaht, Sirli Treumuth, Mirjam Merila, Mari-Liis Ilmoja, Irja Lutsar
BACKGROUND: Human milk is the preferred nutrition for neonates and a source of bacteria. Research aim: The authors aimed to characterize the molecular epidemiology and genetic content of staphylococci in the human milk of mothers of preterm and term neonates. METHODS: Staphylococci were isolated once per week in the 1st month postpartum from the human milk of mothers of 20 healthy term and 49 preterm neonates hospitalized in the neonatal intensive care unit. Multilocus variable-number tandem-repeats analysis and multilocus sequence typing were used...
May 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28413015/-what-to-do-before-a-hypervitaminia-b12-in-the-elderly
#8
REVIEW
Abrar-Ahmad Zulfiqar, Xavier Sui Seng, Elise Duhamel, Nadir Kadri, Jean Doucet, Emmanuel Andres
Hypervitanimia B12 is an early marker of serious pathologies. These include solid neoplasms, malignant blood diseases and acute/chronic hepatopathies. Hypervitaminemia B12 in geriatrics is thereby an indicator in the diagnosis and prognosis of these conditions.
March 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28394804/risk-factors-prevalence-and-site-concordance-of-human-papillomavirus-in-high-risk-greek-men
#9
Savas Tsikis, Lea Hoefer, George Bethimoutis, Electra Nicolaidou, Vassilios Paparizos, Christina Antoniou, Leonidas Chardalias, Georgios-Emmanouil Stavropoulos, Shruti Sharma, Bradley C Long, Ibro Mujacic, Sabah Kadri, Jeremy P Segal, Larissa V Furtado, John Schneider, Angella Charnot-Katsikas
The aim of this study was to determine the risk factors, genotype-specific prevalence, and concordance of human papillomavirus (HPV) infections at three anatomical sites in a cohort of high-risk Greek men. Patients were recruited from sexually transmitted infection and HIV clinics in Athens. Samples were obtained from oral, penile, and anal sites of 294 study participants and HPV testing was performed on 882 samples using next-generation sequencing. Patients also completed a questionnaire assessing risk factors for infection...
April 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28383323/risk-of-epidural-hematoma-after-neuraxial-techniques-in-thrombocytopenic-parturients-a-report-from-the-multicenter-perioperative-outcomes-group
#10
Linden O Lee, Brian T Bateman, Sachin Kheterpal, Thomas T Klumpner, Michelle Housey, Michael F Aziz, Karen W Hand, Mark MacEachern, Christopher G Goodier, Jeffrey Bernstein, Melissa E Bauer, Philip Lirk, Janet Wilczak, Roy Soto, Simon Tom, Germaine Cuff, Daniel A Biggs, Traci Coffman, Leif Saager, Warren J Levy, Michael Godbold, Nathan L Pace, Kevin L Wethington, William C Paganelli, Marcel E Durieux, Karen B Domino, Bala Nair, Jesse M Ehrenfeld, Jonathan P Wanderer, Robert B Schonberger, Joshua Berris, Steven Lins, Peter Coles, Kenneth C Cummings, Kamal Maheshwari, Mitchell F Berman, Christopher Wedeven, John LaGorio, Peter M Fleishut, Terri A Ellis, Susan Molina, Curtis Carl, Bassam Kadry, Wilton A van Klei, Wietze Pasma, Leslie C Jameson, Daniel L Helsten, Michael S Avidan
BACKGROUND: Thrombocytopenia has been considered a relative or even absolute contraindication to neuraxial techniques due to the risk of epidural hematoma. There is limited literature to estimate the risk of epidural hematoma in thrombocytopenic parturients. The authors reviewed a large perioperative database and performed a systematic review to further define the risk of epidural hematoma requiring surgical decompression in this population. METHODS: The authors performed a retrospective cohort study using the Multicenter Perioperative Outcomes Group database to identify thrombocytopenic parturients who received a neuraxial technique and to estimate the risk of epidural hematoma...
April 6, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28382104/comment-on-histomorphological-factors-predicting-the-response-to-neoadjuvant-chemotherapy-in-triple-negative-breast-cancer
#11
COMMENT
Kadri Altundag
No abstract text is available yet for this article.
March 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28382103/comment-on-chemotherapy-induced-left-ventricular-dysfunction-in-patients-with-breast-cancer
#12
COMMENT
Kadri Altundag
No abstract text is available yet for this article.
March 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28381103/predictors-of-in-stent-restenosis-in-patients-with-stable-angina-pectoris
#13
Samet Yilmaz, Mehmet Kadri Akboga, Serkan Topaloglu
No abstract text is available yet for this article.
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28378243/prolonged-suppressive-antibiotic-therapy-for-prosthetic-joint-infection-in-the-elderly-a-national-multicentre-cohort-study
#14
V Prendki, T Ferry, P Sergent, E Oziol, E Forestier, T Fraisse, S Tounes, S Ansart, J Gaillat, S Bayle, O Ruyer, F Borlot, G Le Falher, B Simorre, F-A Dauchy, S Greffe, T Bauer, E N Bell, B Martha, M Martinot, M Froidure, M Buisson, A Waldner, X Lemaire, A Bosseray, M Maillet, V Charvet, A Barrelet, B Wyplosz, M Noaillon, E Denes, E Beretti, M Berlioz-Thibal, V Meyssonnier, E Fourniols, L Tliba, A Eden, M Jean, C Arvieux, K Guignery-Kadri, C Ronde-Oustau, Y Hansmann, A Belkacem, F Bouchand, G Gavazzi, F Herrmann, J Stirnemann, A Dinh
During prosthetic joint infection (PJI), optimal surgical management with exchange of the device is sometimes impossible, especially in the elderly population. Thus, prolonged suppressive antibiotic therapy (PSAT) is the only option to prevent acute sepsis, but little is known about this strategy. We aimed to describe the characteristics, outcome and tolerance of PSAT in elderly patients with PJI. We performed a national cross-sectional cohort study of patients >75 years old and treated with PSAT for PJI...
April 4, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28371477/rafoxanide-and-closantel-inhibit-spak-and-osr1-kinases-by-binding-to-a-highly-conserved-allosteric-site-on-their-c-terminal-domains
#15
Mubarak A Alamri, Hachemi Kadri, Luke J Alderwick, Nigel S Simpkins, Youcef Mehellou
SPAK and OSR1 are two protein kinases that emerged as attractive targets in the discovery of novel antihypertensive agents due to their role in regulating electrolyte balance in vivo. In this work, we report on the identification of an allosteric pocket on their highly conserved C-terminal domains, which influences their kinase activity. Also, we show that some known WNK-signaling inhibitors bind to this allosteric site. Using in silico screening, we identified Rafoxanide, an anti-parasitic agent, as a novel allosteric inhibitor of SPAK and OSR1...
March 31, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28365969/lapatinib-plus-capecitabine-in-metastatic-human-epidermal-growth-factor-receptor-2-positive-breast-cancer-patients-that-received-prior-therapy-with-trastuzumab-and-pertuzumab-better-option-than-t-dm1
#16
Kadri Altundag
No abstract text is available yet for this article.
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28365955/clinicopathological-features-of-patients-with-breast-cancer-aged-70-years-or-over
#17
Aydin Aytekin, Fatih Karatas, Suleyman Sahin, Gokmen U Erdem, Kadri Altundag
PURPOSE: The risk of breast cancer (BC) increases in parallel with increasing age. Despite the increased disease burden in elderly patients, there is still a great uncertainty regarding "how to manage" BC in aging-population. The purpose of this study was to investigate the clinicopathological features and treatment approaches of patients with BC aged 70 years or over. METHODS: The medical records of 4413 patients with BC followed between 1994-2015 were retrospectively analyzed...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28365953/risk-factors-and-histopathological-features-of-breast-cancer-among-women-with-different-menopausal-status-and-age-at-diagnosis
#18
Ozan Unlu, Dilara Kiyak, Canan Caka, Merve Yagmur, Huseyin G Yavas, Fadime Erdogan, Nazli Sener, Bahar Oguz, Taner Babacan, Kadri Altundag
PURPOSE: Although there are studies that investigate different risk factors and clinicopathological features of breast cancer in women at different age groups and menopausal status, there is a need for studies with larger study populations due to controversial findings. We conducted this study to identify demographic parameters in breast cancer patients and histopathological features of the tumors for different age groups and compare them to demonstrate significant differences, if any...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28349935/demographic-associations-for-autoantibodies-in-disease-free-individuals-of-a-european-population
#19
Kadri Haller-Kikkatalo, Kristi Alnek, Andres Metspalu, Evelin Mihailov, Kaja Metsküla, Kalle Kisand, Heti Pisarev, Andres Salumets, Raivo Uibo
The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significant autoantibodies were detected in a subgroup of 994 (auto)immune-mediated disease-free individuals. The overall prevalence of individuals with immune-mediated diseases in the primary cohort was 30.1%. Similarly, 23...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28348635/re-unusual-cause-of-horner-syndrome-13-years-after-in-situ-ductal-carcinoma
#20
Kadri Altundag
No abstract text is available yet for this article.
April 2017: Neuro-ophthalmology
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