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https://www.readbyqxmd.com/read/29040868/identification-of-a-novel-proinsulin-associated-snp-and-demonstration-that-proinsulin-is-unlikely-to-be-a-causal-factor-in-subclinical-vascular-remodelling-using-mendelian-randomisation
#1
Rona J Strawbridge, Angela Silveira, Marcel den Hoed, Stefan Gustafsson, Jian'an Luan, Denis Rybin, Josée Dupuis, Ruifang Li-Gao, Maryam Kavousi, Abbas Dehghan, Kadri Haljas, Jari Lahti, Jesper R Gådin, Alexandra Bäcklund, Ulf de Faire, Karl Gertow, Phillipe Giral, Anuj Goel, Steve E Humphries, Sudhir Kurl, Claudia Langenberg, Lars L Lannfelt, Lars Lind, Cecilia C M Lindgren, Elmo Mannarino, Dennis O Mook-Kanamori, Andrew P Morris, Renée de Mutsert, Rainer Rauramaa, Peter Saliba-Gustafsson, Bengt Sennblad, Andries J Smit, Ann-Christine Syvänen, Elena Tremoli, Fabrizio Veglia, Björn Zethelius, Hanna M Björck, Johan G Eriksson, Albert Hofman, Oscar H Franco, Hugh Watkins, J Wouter Jukema, Jose C Florez, Nicholas J Wareham, James B Meigs, Erik Ingelsson, Damiano Baldassarre, Anders Hamsten
BACKGROUND AND AIMS: Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease (CVD), independently of established risk factors. The mechanisms linking proinsulin to atherosclerosis and CVD are unclear. A genome-wide meta-analysis has identified nine loci associated with circulating proinsulin levels. Using proinsulin-associated SNPs, we set out to use a Mendelian randomisation approach to test the hypothesis that proinsulin plays a causal role in subclinical vascular remodelling...
September 28, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29017994/utilizing-consumer-health-informatics-to-support-management-of-hypertension-by-clinical-pharmacists-in-primary-care-study-protocol
#2
Lorraine R Buis, Dana N Roberson, Reema Kadri, Nicole G Rockey, Melissa A Plegue, Hae Mi Choe, Caroline R Richardson
BACKGROUND: Hypertension (HTN) is a major public health concern in the United States given its wide prevalence, high cost, and poor rates of control. Multiple strategies to counter this growing epidemic have been studied, and home blood pressure (BP) monitoring, mobile health (mHealth) interventions, and referrals to clinical pharmacists for BP management have all shown potential to be effective intervention strategies. OBJECTIVE: The purpose of this study is to establish feasibility and acceptability of BPTrack, a clinical pharmacist-led mHealth intervention that aims to improve BP control by supporting home BP monitoring and medication adherence among patients with uncontrolled HTN...
October 10, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28971867/role-of-alanine-racemase-mutations-in-mycobacterium-tuberculosis-d-cycloserine-resistance
#3
Yoshio Nakatani, Helen K Opel-Reading, Matthias Merker, Diana Machado, Sönke Andres, S Siva Kumar, Danesh Moradigaravand, Francesc Coll, João Perdigão, Isabel Portugal, Thomas Schön, Dina Nair, K R Uma Devi, Thomas A Kohl, Patrick Beckert, Taane G Clark, Gugu Maphalala, Derrick Khumalo, Roland Diel, Kadri Klaos, Htin Lin Aung, Gregory M Cook, Julian Parkhill, Sharon J Peacock, Soumya Swaminathan, Miguel Viveiros, Stefan Niemann, Kurt L Krause, Claudio U Köser
Screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to D-cycloserine.
October 2, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28956436/effective-approach-for-increasing-the-heteroatom-doping-levels-of-porous-carbons-for-superior-co2-capture-and-separation-performance
#4
Yomna H Abdelmoaty, Tsemre-Dingel Tessema, Nazgol Norouzi, Oussama M El-Kadri, Joseph B McGee Turner, Hani M El-Kaderi
Development of efficient sorbents for carbon dioxide (CO2) capture from flue gas or its removal from natural gas and landfill gas is very important for environmental protection. A new series of heteroatom-doped porous carbon was synthesized directly from pyrazole/KOH by thermolysis. The resulting pyrazole-derived carbons (PYDCs) are highly doped with nitrogen (14.9-15.5 wt %) as a result of the high nitrogen-to-carbon ratio in pyrazole (43 wt %) and also have a high oxygen content (16.4-18.4 wt %). PYDCs have a high surface area (SABET = 1266-2013 m(2) g(-1)), high CO2 Qst (33...
October 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28952238/prognosis-of-women-with-invasive-pleomorphic-lobular-carcinoma-compared-with-classical-invasive-lobular-carcinoma-still-debatable-issue
#5
Kadri Altundag
No abstract text is available yet for this article.
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28952236/should-patients-with-her2-loss-after-neoadjuvant-treatment-still-be-treated-with-adjuvant-trastuzumab-treatment
#6
Kadri Altundag
No abstract text is available yet for this article.
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28952233/t1-invasive-breast-lobular-tumor-and-ductal-carcinoma-with-her-2-positive-characteristics-is-it-rationale-to-use-adjuvant-trastuzumab
#7
Kadri Altundag
No abstract text is available yet for this article.
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28952231/metastasis-acquired-changes-in-clinically-actionable-genes-in-triple-negative-breast-cancer-patients-with-central-nervous-system-metastases-focus-on-her2-targeted-therapies
#8
Kadri Altundag
No abstract text is available yet for this article.
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28941674/do-oil-in-water-o-w-nano-emulsions-have-an-effect-on-survival-and-growth-of-bacteria
#9
Hani El Kadri, Putu Virgina Partha Devanthi, Tim W Overton, Konstantinos Gkatzionis
Nano-emulsions (typically droplet diameter<1μm) are common in foods, and have been extensively reported to present antimicrobial activity, however, the mechanism is not well defined, and some studies reported no effect. A review of the literature was conducted and revealed strongly contradictory reports regarding the antimicrobial effect of nano-emulsions even in reference to similar microbial species and formulations. Following up, this study aimed to investigate the effect of nano-emulsions on four bacterial species (Staphylococcus epidermidis, Bacillus cereus, Lactobacillus acidophilus and five Escherichia coli strains) possessing different surface charge and hydrophobicity...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28927207/surgical-approaches-to-the-temporal-horn-an-anatomic-analysis-of-white-matter-tract-interruption
#10
Paulo A S Kadri, Jean G de Oliveira, Niklaus Krayenbühl, Ugur Türe, Evandro P L de Oliveira, Ossama Al-Mefty, Guilherme C Ribas
BACKGROUND: Surgical access to the temporal horn is necessary to treat tumors and vascular lesions, but is used mainly in patients with mediobasal temporal epilepsy. The surgical approaches to this cavity fall into 3 primary categories: lateral, inferior, and transsylvian. The current neurosurgical literature has underestimated the interruption of involved fiber bundles and the correlated clinical manifestations. OBJECTIVE: To delineate the interruption of fiber bundles during the different approaches to the temporal horn...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28917909/development-of-poly-1-8-octanediol-citrate-chitosan-blend-films-for-tissue-engineering-applications
#11
Ehsan Zeimaran, Sara Pourshahrestani, Belinda Pingguan-Murphy, Daniel Kong, Sangeetha Vasudevaraj Naveen, Tunku Kamarul, Nahrizul Adib Kadri
Blends of poly (1, 8-octanediol citrate) (POC) and chitosan (CS) were prepared through solution casting technique. Films with different component fractions (POC/CS: 100/0, 90/10, 80/20, 70/30, 60/40, and 0/100) were successfully prepared and characterized for their mechanical, thermal, structural and morphological properties as well as biocompatibility. The incorporation of CS to POC significantly increased tensile strength and elastic modulus and presented limited influences on pH variation which is important to the biocompatibility of biomaterial implants...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917337/29-hyperparathyro%C3%A3-die-primitive-chez-le-sujet-%C3%A3-g%C3%A3
#12
Ségolène Samson, Alain Jego, Nadir Kadri, Jean Doucet, Abrar-Ahmad Zulfiqar
No abstract text is available yet for this article.
September 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28903761/protective-effects-of-grape-seed-and-skin-extract-against-high-fat-diet-induced-lipotoxicity-in-rat-lung
#13
Mohamed El Ayed, Safwen Kadri, Selima Smine, Salem Elkahoui, Ferid Limam, Ezzedine Aouani
BACKGROUND: Obesity is a public health problem characterized by increased fat accumulation in different tissues. Obesity is directly linked to breathing problems and medical complications with lung, including obstructive sleep apnea syndrome, obesity hypoventilation syndrome, chronic obstructive pulmonary disease, asthma….In the present work, we aimed to investigate the effect of high fat diet (HFD) on lung lipotoxicity, oxidative stress, fatty acid composition and proportions in lung and implication in asthma development...
September 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28903154/incidence-and-trends-of-sepsis-in-us-hospitals-using-clinical-vs-claims-data-2009-2014
#14
COMPARATIVE STUDY
Chanu Rhee, Raymund Dantes, Lauren Epstein, David J Murphy, Christopher W Seymour, Theodore J Iwashyna, Sameer S Kadri, Derek C Angus, Robert L Danner, Anthony E Fiore, John A Jernigan, Greg S Martin, Edward Septimus, David K Warren, Anita Karcz, Christina Chan, John T Menchaca, Rui Wang, Susan Gruber, Michael Klompas
Importance: Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from claims data may lack clinical fidelity and can be affected by changing diagnosis and coding practices over time. Objective: To estimate the US national incidence of sepsis and trends using detailed clinical data from the electronic health record (EHR) systems of diverse hospitals. Design, Setting, and Population: Retrospective cohort study of adult patients admitted to 409 academic, community, and federal hospitals from 2009-2014...
October 3, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28893761/effectiveness-of-expanding-annual-mass-azithromycin-distribution-treatment-coverage-for-trachoma-in-niger-a-cluster-randomised-trial
#15
Abdou Amza, Boubacar Kadri, Beido Nassirou, Sun Y Cotter, Nicole E Stoller, Sheila K West, Robin L Bailey, Travis C Porco, Bruce D Gaynor, Jeremy D Keenan, Thomas M Lietman, Catherine E Oldenburg
BACKGROUND/AIMS: The WHO recommends 3-5 years of annual mass azithromycin distribution with at least 80% treatment coverage to districts with active trachoma prevalence over 10% among children. Here, we assess the efficacy of expanding the coverage target to at least 90% for trachoma control in a mesoendemic region of Niger. METHODS: Twenty-four communities were randomised to a single day of azithromycin distribution with a coverage target of 80% of the community or up to 4 days of treatment, aiming for greater than 90% coverage...
September 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28893697/incidence-of-postoperative-hematomas-requiring-surgical-treatment-in-neurosurgery-a-retrospective-observational-study
#16
Kadri Lillemäe, Johanna Järviö, Marja Kaarina Silvasti-Lundell, Jussi Antinheimo, Juha Hernesniemi, Tomi Tapio Niemi
OBJECTIVE: We aimed to characterize the occurrence of postoperative hematoma (POH) after neurosurgery overall and according to procedure type, and describe the prevalence of possible confounders. METHODS: Patient data between 2010 and 2012 at the Department of Neurosurgery in Helsinki University Hospital were retrospectively analyzed. Data search was performed according to the type of surgery including craniotomies; shunt procedures, spine surgery and spinal cord stimulators (SCS) implantation...
September 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28888432/incorporation-of-water-in-oil-in-water-w1-o-w2-double-emulsion-in-a-set-type-yogurt-model
#17
Sofia Lalou, Hani El Kadri, Konstantinos Gkatzionis
The effect of W1/O/W2 emulsion incorporation in set-type yogurt on the acidification process, physicochemical properties, bacterial growth kinetics and structural characteristics was investigated. The W1/O/W2 emulsion was formed by using a two-step homogenisation process and milk as the W1 and W2 phases, and stability was monitored with optical microscopy and cryo-SEM. Adding the W1/O/W2 emulsions reduced the acidification rate, viscosity and water retention capacity. Texture (adhesiveness, cohesiveness, hardness, and gumminess) differed in yogurts containing W1/O/W2 emulsion compared to controls during the acidification process, however, trends became stable during storage...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28881465/wnk-signaling-inhibitors-as-potential-antihypertensive-drugs
#18
REVIEW
Mubarak A AlAmri, Hachemi Kadri, Binar A Dhiani, Shumail Mahmood, Abdulrahman Elzwawi, Youcef Mehellou
Since the discovery of WNK mutations that cause an inherited form of hypertension in humans, there has been increasing interest in targeting WNK signaling as a novel strategy for modulating blood pressure. This notion is now supported by numerous mouse models with impaired WNK signaling that exhibit reduced blood pressure. Biochemical analyses of the various protein components that make up this signaling pathway have identified a number of plausible molecular targets that are amenable to targeting by small molecules...
September 7, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28862870/general-formalism-of-vibronic-hamiltonians-for-tetrahedral-and-octahedral-systems-problems-that-involve-t-e-states-and-t-e-vibrations
#19
Tao Zeng, Riley J Hickman, Aya Kadri, Issaka Seidu
We derive expansion formulas up to arbitrary order in vibrational coordinates for the tetrahedral and octahedral vibronic Hamiltonians that involve T and E states, and t and e vibrations. These states feature both Jahn-Teller (JT) and pseudo-Jahn-Teller (pJT) effects, and the vibrations are the most JT and pJT active. We first derive the formulas for 92 problems of T and Td symmetries involving up to two vibrational modes. The formulas can be easily generalized to problems of Th, O, and Oh symmetries, as well as problems involving more than two vibrational modes...
September 26, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28862425/btn3a1-discriminates-%C3%AE-%C3%AE-t-cell-phosphoantigens-from-nonantigenic-small-molecules-via-a-conformational-sensor-in-its-b30-2-domain
#20
Mahboob Salim, Timothy J Knowles, Alfie T Baker, Martin S Davey, Mark Jeeves, Pooja Sridhar, John Wilkie, Carrie R Willcox, Hachemi Kadri, Taher E Taher, Pierre Vantourout, Adrian Hayday, Youcef Mehellou, Fiyaz Mohammed, Benjamin E Willcox
Human Vγ9/Vδ2 T-cells detect tumor cells and microbial infections by recognizing small phosphorylated prenyl metabolites termed phosphoantigens (P-Ag). The type-1 transmembrane protein Butyrophilin 3A1 (BTN3A1) is critical to the P-Ag-mediated activation of Vγ9/Vδ2 T-cells; however, the molecular mechanisms involved in BTN3A1-mediated metabolite sensing are unclear, including how P-Ag's are discriminated from nonantigenic small molecules. Here, we utilized NMR and X-ray crystallography to probe P-Ag sensing by BTN3A1...
September 14, 2017: ACS Chemical Biology
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