keyword
https://read.qxmd.com/read/38193233/tick-bites-ige-to-galactose-alpha-1-3-galactose-and-urticarial-or-anaphylactic-reactions-to-mammalian-meat-the-alpha-gal-syndrome
#21
REVIEW
Jeffrey M Wilson, Loren Erickson, Michael Levin, Samuel M Ailsworth, Scott P Commins, Thomas A E Platts-Mills
The recent recognition of a syndrome of tick-acquired mammalian meat allergy has transformed the previously held view that mammalian meat is an uncommon allergen. The syndrome, mediated by IgE antibodies against the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), can also involve reactions to visceral organs, dairy, gelatin and other products, including medications sourced from non-primate mammals. Thus, fittingly, this allergic disorder is now called the alpha-gal syndrome (AGS). The syndrome is strikingly regional, reflecting the important role of tick bites in sensitization, and is more common in demographic groups at risk of tick exposure...
January 9, 2024: Allergy
https://read.qxmd.com/read/38182056/development-of-anti-peg-igg-igm-ige-elisa-assays-for-profiling-anti-peg-immunoglobulin-response-in-peg-sensitized-individuals-and-patients-with-alpha-gal-allergy
#22
JOURNAL ARTICLE
Zhongbo Li, Alice Ma, Ian Miller, Rachel Starnes, Anne Talkington, Cosby A Stone, Elizabeth J Phillips, Shailesh K Choudhary, Scott P Commins, Samuel K Lai
Polyethylene glycol (PEG) is frequently used in various protein and nanomedicine therapeutics. However, various studies have shown that select PEGylated therapeutics can induce production of anti-PEG antibodies (APA), potentially culminating in rapid clearance from the systemic circulation, loss of efficacy and possibly increased risks of allergic reactions. Although IgE is a frequent cause of immediate hypersensitivity reactions (IHR), the role of IgE APA in PEG-related IHR is not well understood, due in part to a lack of standardized assays for measuring IgE APA...
January 8, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38181526/integrated-microbiome-and-metabolomics-revealed-the-protective-effect-of-baicalin-on-alveolar-bone-inflammatory-resorption-in-aging
#23
JOURNAL ARTICLE
Huan Hu, Yanzi Yao, Fangzhou Liu, Liangliang Luo, Jianguo Liu, Xinyu Wang, Qian Wang
BACKGROUND: With the growing aging population and longer life expectancy, periodontitis and tooth loss have become major health concerns. The gut microbiota, as a key regulator in bone homeostasis, has gathered immense interest. Baicalin, a flavonoid compound extracted from Scutellaria baicalensis Georgi, has shown antioxidant and anti-inflammatory activities. PURPOSE: This study investigated, for the first time, the protective mechanism of baicalin against alveolar bone inflammatory resorption in aging mice by regulating intestinal flora and metabolites, as well as intestinal barrier function...
December 7, 2023: Phytomedicine
https://read.qxmd.com/read/38155709/novel-enhancer-mediates-the-rpl36a-hnrnph2-readthrough-loci-and-gla-gene-expressions-associated-with-fabry-disease
#24
JOURNAL ARTICLE
Mohammed A Al-Obaide, Saimul Islam, Ibtisam Al-Obaidi, Tetyana L Vasylyeva
Fabry disease (FD) is a rare genetic condition caused by mutations in the GLA gene, located on the X chromosome in the RPL36-HNRNPH2 readthrough genomic region. This gene produces an enzyme called alpha-galactosidase A (α-Gal A). When the enzyme does not function properly due to the mutations, it causes harmful substances called globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3) to build up in the body's lysosomes. This accumulation can damage the kidneys, heart, eyes, and nervous system...
2023: Frontiers in Genetics
https://read.qxmd.com/read/38135009/ige-and-anaphylaxis-specific-to-the-carbohydrate-alpha-gal-depend-on-interleukin-4
#25
JOURNAL ARTICLE
Miriam Hils, Nils Hoffard, Caterina Iuliano, Luisa Kreft, Neera Chakrapani, Kyra Swiontek, Konrad Fischer, Bernadette Eberlein, Martin Köberle, Jörg Fischer, Christiane Hilger, Caspar Ohnmacht, Susanne Kaesler, Florian Wölbing, Tilo Biedermann
BACKGROUND: Alpha-gal (Galα1-3Galβ1-4GlcNAc) is a carbohydrate with the potential to elicit fatal allergic reactions to mammalian meat and drugs of mammalian origin. This type of allergy is induced by tick bites and therapeutic options for this skin-driven food allergy are limited to the avoidance of the allergen and treatment of symptoms. Thus, a better understanding of the immune mechanisms resulting in sensitization through the skin is crucial, especially in the case of a carbohydrate allergen for which underlying immune responses are poorly understood...
December 20, 2023: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38114119/-aucubin-combined-with-adscs-exos-protects-tbhp-induced-nucleus-pulposus-cells-via-tlr4-nf-%C3%AE%C2%BAb-pathway
#26
JOURNAL ARTICLE
Lei Yang, Zhao-Yong Li, Lu Ma, Yan-Tao Guo, Shao-Feng Yang, Hui Xiong, Bo-Yu Wu, Jia-Hao Duan, En-Xu Liu, Chao Zhang, Ying Nie, Long Chen, Lin-Quan Liu
This paper aims to investigate the effects and mechanisms of adipose-derived stem cells-exosomes(ADSCs-exos) toge-ther with aucubin in protecting human-derived nucleus pulposus cells(NPCs) from inflammatory injury, senescence, and apoptosis. The tert-butyl hydroperoxide(TBHP)-induced NPCs were assigned into normal, model, aucubin, ADSCs-exos, and aucubin+ADSCs-exos groups. The cell viability was examined by cell counting kit-8(CCK-8), cell proliferation by EdU staining, cell senescence by senescence-associated-β-galactosidase(SA-β-Gal), and cell cycle and apoptosis by flow cytometry...
October 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38072514/lasofoxifene-versus-fulvestrant-for-er-her2-metastatic-breast-cancer-with-an-esr1-mutation-results-from-the-randomized-phase-ii-elaine-1-trial
#27
RANDOMIZED CONTROLLED TRIAL
M P Goetz, N A Bagegni, G Batist, A Brufsky, M A Cristofanilli, S Damodaran, B R Daniel, G F Fleming, W J Gradishar, S L Graff, M T Grosse Perdekamp, E Hamilton, S Lavasani, A Moreno-Aspitia, T O'Connor, T J Pluard, H S Rugo, S L Sammons, L S Schwartzberg, D G Stover, G A Vidal, G Wang, E Warner, R Yerushalmi, P V Plourde, D J Portman, E N Gal-Yam
BACKGROUND: Acquired estrogen receptor alpha (ER/ESR1) mutations commonly cause endocrine resistance in ER+ metastatic breast cancer (mBC). Lasofoxifene, a novel selective ER modulator, stabilizes an antagonist conformation of wild-type and ESR1-mutated ER-ligand binding domains, and has antitumor activity in ESR1-mutated xenografts. PATIENTS AND METHODS: In this open-label, randomized, phase II, multicenter, ELAINE 1 study (NCT03781063), we randomized women with ESR1-mutated, ER+/human epidermal growth factor receptor 2 negative (HER2-) mBC that had progressed on an aromatase inhibitor (AI) plus a cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) to oral lasofoxifene 5 mg daily or IM fulvestrant 500 mg (days 1, 15, and 29, and then every 4 weeks) until disease progression/toxicity...
December 2023: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://read.qxmd.com/read/38072338/just-a-phase-causal-probing-reveals-spurious-phasic-dependence-of-sustained-attention
#28
JOURNAL ARTICLE
M Vinao-Carl, Y Gal-Shohet, E Rhodes, J Li, A Hampshire, D Sharp, N Grossman
For over a decade, electrophysiological studies have reported correlations between attention / perception and the phase of spontaneous brain oscillations. To date, these findings have been interpreted as evidence that the brain uses neural oscillations to sample and predict upcoming stimuli. Yet, evidence from simulations have shown that analysis artefacts could also lead to spurious pre-stimulus oscillations that appear to predict future brain responses. To address this discrepancy, we conducted an experiment in which visual stimuli were presented in time to specific phases of spontaneous alpha and theta oscillations...
December 10, 2023: NeuroImage
https://read.qxmd.com/read/38064235/what-is-alpha-gal-syndrome
#29
JOURNAL ARTICLE
Fatema Mollah, Mark A Zacharek, Mariel R Benjamin
No abstract text is available yet for this article.
December 8, 2023: JAMA
https://read.qxmd.com/read/38049505/high-levels-of-alpha-gal-with-large-variation-in-the-salivary-glands-of-lone-star-ticks-fed-on-human-blood
#30
JOURNAL ARTICLE
L Paulina Maldonado-Ruiz, Kathryn E Reif, Anuradha Ghosh, Stephanie Foré, Rachel L Johnson, Yoonseong Park
Tick bites, associated with the secretion of tick saliva containing the xenoglycan galactose-alpha-1, 3-galactose (alpha-gal or aGal), are recognized as the causal factors of alpha-Gal syndrome (AGS; or red meat allergy) in humans. AGS occurs after the increased production of IgE antibodies against aGal, which is found in most mammalian cells, except for the Old World monkey and humans. The aGal sensitization event has been linked to an initial tick bite, followed by consumption of red meat containing the aGal glycan, which triggers the onset of the allergic response resulting in urticaria, anaphylaxis, or even death...
December 4, 2023: Scientific Reports
https://read.qxmd.com/read/38037176/diagnostic-validity-of-specific-immunoglobulin-e-levels-to-alpha-gal-in-alpha-gal-syndrome-a-cross-sectional-analysis
#31
JOURNAL ARTICLE
Adrián Germán-Sánchez, Ana Alonso-Llamazares, Fernando García-González, Bakai Matala-Ahmed, Ceny Solani Melgar-Reyes, Ignacio Antepara-Ercoreca
BACKGROUND: The diagnosis of Alpha-gal Syndrome (AGS) is based on the presence of symptoms after being exposed to potential sources of alpha-gal together with values ​​of specific IgE (sIgE) to alpha-gal ≥ 0.1 kUA/L or ≥ 0.35 kUA/L. The aim of this study was to evaluate the diagnostic validity of sIgE levels to alpha-gal ≥ 0.1 kUA/L for identifying AGS. METHODS: This was a cross-sectional analysis of adult patients with available data on sIgE levels to alpha-gal, classified into two groups according to the presence (Group 1) or absence (Group 2) of symptoms after being exposed to potential sources of alpha-gal...
November 30, 2023: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/38014105/tick-bite-induced-alpha-gal-syndrome-and-immunologic-responses-in-an-alpha-gal-deficient-murine-model
#32
Surendra Raj Sharma, Shailesh K Choudhary, Julia Vorobiov, Scott P Commins, Shahid Karim
INTRODUCTION: Alpha-Gal Syndrome (AGS) is a delayed allergic reaction due to specific IgE antibodies targeting galactose-α-1,3-galactose (α-gal), a carbohydrate found in red meat. This condition has gained significant attention globally due to its increasing prevalence, with more than 450,000 cases estimated in the United States alone. Previous research has established a connection between AGS and tick bites, which sensitize individuals to α-gal antigens and elevate the levels of α-gal specific IgE...
November 13, 2023: bioRxiv
https://read.qxmd.com/read/38010429/allergic-reactions-associated-with-medically-relevant-arthropods
#33
JOURNAL ARTICLE
Rita Vaz-Rodrigues, Francisco Feo Brito, Raúl Guzmán Rodríguez, Lorena Mazuecos, José de la Fuente
OBJECTIVE: Vector-borne diseases are a growing burden worldwide. In particular, the risks of allergic reactions to bites are associated with growing arthropod populations in contact with the public. The diversity of allergic reactions associated with host and arthropod factors difficult disease diagnosis, prognosis and prevention. Therefore, arthropod-associated allergies are underdiagnosed and require better surveillance of arthropod populations and disease diagnosis and management. METHODS: To face these challenges, in this study, we describe five cases to illustrate arthropod-associated allergies with different symptomatology, including alpha-gal syndrome (AGS) associated with anti-alpha-gal IgE antibody titres...
2023: Annals of Medicine
https://read.qxmd.com/read/38008711/ezh2-h3k27me3-mediated-silencing-of-mir-139-5p-inhibits-cellular-senescence-in-hepatocellular-carcinoma-by-activating-top2a
#34
JOURNAL ARTICLE
Ke Wang, Xunliang Jiang, Yu Jiang, Jun Liu, Yongtao Du, Zecheng Zhang, Yunlong Li, Xinhui Zhao, Jipeng Li, Rui Zhang
BACKGROUND: Epigenetic alterations play an important role in hepatocellular carcinoma (HCC) development. Enhancer of zeste homolog 2 (EZH2) is a well-known epigenetic modifier that functions as an oncogene in tumors by promoting the H3K27me3-mediated transcriptional repression of tumor suppressor genes. "Senescent cells" has been proposed as a possible core component of the hallmarks of cancer conceptualization. Induction of cell senescence and targeted elimination of these senescent tumor cells are new strategies for tumor therapy...
November 27, 2023: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/37985065/enzymatically-derived-oligo-carrageenans-interact-with-%C3%AE-gal-antibodies-and-galectin-3
#35
JOURNAL ARTICLE
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Carrageenans are linear sulfated galactans synthesized in the Gigartinales, Rhodophyceae species with a varied range of biological properties that are of value to the pharmaceutical and cosmetic sectors. It is unknown how the fine structure of carrageenans dictates their capacity to affect molecular and cellular responses important to wound healing, or the ability to mitigate oxidative, hemostatic and inflammatory processes. Here we use specific endo-carrageenases, from the marine bacterium Zobellia galactanivorans, to produce enzymatically defined neo-series oligosaccharides from carrageenans with 3,6-anhydro-D-galactose on the non-reducing end...
January 15, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/37949029/the-free-viewing-matrix-task-a-reliable-measure-of-attention-allocation-in-psychopathology
#36
JOURNAL ARTICLE
Dana Shamai-Leshem, Rany Abend, Gal Arad, Omer Azriel, Lyndsey Chong, Peter de Jong, Chelsea Dyan Gober Dykan, Greg Hajcak, Julia Klawohn, Alexandria Meyer, Klavdia Neophytou, Yuval Neria, Georgia Panayiotou, Franklin Schneier, Ali Soleymani, Noga Yair, Daniel S Pine, Yair Bar-Haim, Amit Lazarov
Aberrant attention allocation has been implicated in the etiology and maintenance of a range of psychopathologies. However, three decades of research, relying primarily on manual response-time tasks, have been challenged on the grounds of poor reliability of its attention bias indices. Here, in a large, multisite, international study we provide reliability information for a new eye-tracking-based measure of attention allocation and its relation to psychopathology and age. Data from 1567 participants, across a wide range of psychiatric diagnoses and ages, were aggregated from nine sites around the world...
October 27, 2023: Journal of Anxiety Disorders
https://read.qxmd.com/read/37943208/ige-to-common-food-allergens-is-associated-with-cardiovascular-mortality-in-the-national-health-and-examination-survey-and-the-multi-ethnic-study-of-atherosclerosis
#37
JOURNAL ARTICLE
Corinne Keet, Emily C McGowan, David Jacobs, Wendy S Post, Nathan E Richards, Lisa J Workman, Thomas A E Platts-Mills, Ani Manichaikul, Jeffrey M Wilson
BACKGROUND: In individuals without symptomatic food allergy, food-specific IgE is considered clinically irrelevant. However, recent studies have suggested that galactose-α-1,3-galactose (alpha-gal) IgE is associated with cardiovascular (CV) disease. OBJECTIVE: We sought to determine whether sensitization to common food allergens is associated with CV mortality. METHODS: The association between IgE sensitization to foods and CV mortality ascertained to 2019 was examined in the National Health and Examination Survey (NHANES) 2005-2006 and the Wake Forest site of the Multi-Ethnic Study of Atherosclerosis (MESA) cohort; MESA enrolled adults without baseline clinical CV diseases between 2000 and 2002...
February 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/37942832/d-galactose-induces-the-senescence-and-phenotype-switch-of-corpus-cavernosum-smooth-muscle-cells
#38
JOURNAL ARTICLE
Daoyuan Hu, Yunlong Ge, Lei Ye, Yuhang Xi, Jialiang Chen, Wenliang Zhu, Zhenqing Wang, Zhuolun Sun, Ying Su, Dejuan Wang, Shiwei Xiao, Jianguang Qiu
Studies regarding age-related erectile dysfunction (ED) based on naturally aging models are limited by their high costs, especially for the acquisition of primary cells from the corpus cavernosum. Herein, d-galactose ( d-gal) was employed to accelerate cell senescence, and the underlying mechanism was explored. As predominant functional cells involved in the erectile response, corpus cavernosum smooth muscle cells (CCSMCs) were isolated from 2-month-old rats. Following this, d-gal was introduced to induce cell senescence, which was verified via β-galactosidase staining...
November 9, 2023: Journal of Cellular Physiology
https://read.qxmd.com/read/37936368/use-of-antithymocyte-globulin-rabbit-in-a-patient-with-known-alpha-gal-syndrome-undergoing-allogenic-stem-cell-transplantation
#39
JOURNAL ARTICLE
Hannah Peterson, Drew A Wells, Dennis Marjoncu, Kori Holman
INTRODUCTION: Alpha-gal syndrome (AGS) is a hypersensitivity disorder in which tick bites-most commonly from the lone star tick ( Ambylomma americanum )-trigger immunoglobulin E-mediated hypersensitivity reaction upon exposure to oligosaccharide galactosse-alpha-1,3-galactose (α-gal). α-gal is most notorious for being found in "red meat" products but is present in mammalian meats such as beef, pork, lamb, rabbit, and others. Manifestations of AGS hypersensitivity are variable...
November 7, 2023: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/37922649/multi-omics-analysis-of-zebrafish-response-to-tick-saliva-reveals-biological-processes-associated-with-alpha-gal-syndrome
#40
JOURNAL ARTICLE
Rita Vaz-Rodrigues, Lorena Mazuecos, Margarita Villar, Marinela Contreras, Sara Artigas-Jerónimo, Almudena González-García, Christian Gortázar, José de la Fuente
The alpha-Gal syndrome (AGS) is a tick-borne allergy. A multi-omics approach was used to determine the effect of tick saliva and mammalian meat consumption on zebrafish gut transcriptome and proteome. Bioinformatics analysis using R software was focused on significant biological and metabolic pathway changes associated with AGS. Ortholog mapping identified highly concordant human ortholog genes for the detection of disease-enriched pathways. Tick saliva treatment increased zebrafish mortality, incidence of hemorrhagic type allergic reactions and changes in behavior and feeding patterns...
December 2023: Biomedicine & Pharmacotherapy
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