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https://www.readbyqxmd.com/read/29774798/book-review-martin-halliwell-voices-of-mental-health-medicine-politics-and-american-culture-1970-2000-halliwell-martin-voices-of-mental-health-medicine-politics-and-american-culture-1970-2000-rutgers-university-press-new-brunswick-camden-newark-nj-and-london
#1
https://www.readbyqxmd.com/read/29772837/conventional-pathology-versus-gene-signatures-for-assessing-luminal-a-and-b-type-breast-cancers-results-of-a-prospective-cohort-study
#2
Julia E C van Steenhoven, Anne Kuijer, Paul J van Diest, Joost M van Gorp, Marieke Straver, Sjoerd G Elias, Jelle Wesseling, Emiel Rutgers, Johanna N H Timmer-Bonte, Peter Nieboer, Tineke J Smilde, Alex Imholz, Charlotte F J M Blanken, Sabine Siesling, Thijs van Dalen
In this study, in estrogen receptor positive (ER+) early stage breast cancer patients who were considered candidates for 70-gene signature (70-GS, "MammaPrint") use, we compared molecular subtyping (MS) based on the previously validated 80-gene signature (80-GS, "BluePrint") versus surrogate pathological subtyping (PS). Between 1 January 2013 and 31 December 2015, 595 clinical intermediate risk ER+ early stage breast cancer patients were enrolled. Hormone receptor (HR) and HER2 receptor status were determined by conventional pathology using immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH)...
May 17, 2018: Genes
https://www.readbyqxmd.com/read/29770855/the-european-society-of-paediatric-radiology-launches-european-diploma-in-paediatric-radiology
#3
REVIEW
Samuel Stafrace, Rutger A J Nievelstein, Maria Raissaki
ᅟ.
May 17, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29767226/evaluation-of-the-wear-and-tear-scale-for-therapeutic-footwear-results-of-a-generalizability-study
#4
Rutger Dahmen, Petra C Siemonsma, Sandra Monteiro, Geoffrey R Norman, Maarten Boers, Gustaaf J Lankhorst, Leo D Roorda
OBJECTIVE: Therapeutic footwear is often prescribed at considerable cost. Foot-care specialists normally assess the wear-and-tear of therapeutic footwear in order to monitor the adequacy of the prescribed footwear and to gain an indicator of its use. We developed a simple, rapid, easily applicable indicator of wear-and-tear of therapeutic footwear: the wear-and-tear scale. The aim of this study was to investigate the intra- and inter-rater reliability of the wear-and-tear scale. METHODS: A test set of 100 therapeutic shoes was assembled; 24 raters (6 inexperienced and 6 experienced physiatrists, and 6 inexperienced and 6 experienced orthopaedic shoe technicians) rated the degree of wear-and-tear of the shoes on the scale (range 0-100) twice on 1 day with a 4-h interval (short-term) and twice over a 4-week interval (long-term)...
May 16, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29762480/time-course-microarray-analysis-reveals-differences-between-transcriptional-changes-in-tomato-leaves-triggered-by-mild-and-severe-variants-of-potato-spindle-tuber-viroid
#5
Aneta Więsyk, Roksana Iwanicka-Nowicka, Anna Fogtman, Włodzimierz Zagórski-Ostoja, Anna Góra-Sochacka
Viroids are small non-capsidated non-coding RNA replicons that utilize host factors for efficient propagation and spread through the entire plant. They can incite specific disease symptoms in susceptible plants. To better understand viroid-plant interactions, we employed microarray analysis to observe the changes of gene expression in "Rutgers" tomato leaves in response to the mild (M) and severe (S23) variants of potato spindle tuber viroid (PSTVd). The changes were analyzed over a time course of viroid infection development: (i) the pre-symptomatic stage; (ii) early symptoms; (iii) full spectrum of symptoms and (iv) the so-called 'recovery' stage, when stem regrowth was observed in severely affected plants...
May 15, 2018: Viruses
https://www.readbyqxmd.com/read/29759432/incidence-of-pulmonary-vein-stenosis-after-radiofrequency-catheter-ablation-of-atrial-fibrillation
#6
Cas Teunissen, Birgitta K Velthuis, Rutger J Hassink, Jeroen F van der Heijden, Evert-Jan P A Vonken, Nick Clappers, Pieter A Doevendans, Peter Loh
OBJECTIVES: This study aimed to determine incidence of pulmonary vein stenosis (PVS) and evaluate PVS-related symptoms. BACKGROUND: The real-life incidence of PVS after radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) is unknown. METHODS: All patients who underwent RFCA of AF from 2005 to 2016 with routine pre- and post-ablation screening by magnetic resonance imaging or computed tomography were included. Primary ablation strategy was PV antrum isolation alone in all patients...
June 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29758129/twenty-four-hour-normothermic-perfusion-of-discarded-human-kidneys-with-urine-recirculation
#7
Annemarie Weissenbacher, Letizia Lo Faro, Olga Boubriak, Maria F Soares, Ian S Roberts, James P Hunter, Daniel Voyce, Nikolay Mikov, Andrew Cook, Rutger J Ploeg, Constantin C Coussios, Peter J Friend
Transportable normothermic kidney perfusion for 24 hours or longer could enable viability assessment of marginal grafts, increased organ utilization and improved transplantation logistics. Eleven clinically-declined kidneys were perfused normothermically, six from donors after brain stem death (DBD, median cold ischemia time 33±36.9 hours) and five from donors after circulatory death (DCD, 36.2±38.3 hours): n=3 kidneys were perfused using Ringer's lactate to replace excreted urine volume, and n=8 using urine recirculation to maintain perfusate volume without fluid replenishment...
May 14, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29750749/vemurafenib-in-braf-mutant-metastatic-melanoma-patients-in-real-world-clinical-practice-prognostic-factors-associated-with-clinical-outcomes
#8
Maartje G Schouwenburg, Anouk Jochems, Brenda Leeneman, Margreet G Franken, Alfons J M van den Eertwegh, John B A G Haanen, Michiel C T van Zeijl, Maureen J Aarts, Alexander C J van Akkooi, Franchette W P J van den Berkmortel, Willeke A M Blokx, Jan Willem B de Groot, Geke A P Hospers, Ellen Kapiteijn, Rutger H Koornstra, Wim H Kruit, Marieke W J Louwman, Djura Piersma, Rozemarijn S van Rijn, Karijn P M Suijkerbuijk, Albert J Ten Tije, Gerard Vreugdenhil, Michel W J M Wouters, Jacobus J M van der Hoeven
The aim of this population-based study was to identify the factors associated with clinical outcomes in vemurafenib-treated patients and to evaluate outcomes across subgroups of patients with different risk profiles. Data were retrieved from the Dutch Melanoma Treatment Registry. Time to next treatment (TTNT) and overall survival (OS) of all metastatic melanoma patients who received vemurafenib between 2012 and 2015 were assessed using Kaplan-Meier estimates. A risk score was developed on the basis of all prognostic factors associated with TTNT and OS derived from multivariable Cox regression analyses...
May 10, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29747618/evaluation-of-a-multimodal-school-based-depression-and-suicide-prevention-program-among-dutch-adolescents-design-of-a-cluster-randomized-controlled-trial
#9
Mandy W M Gijzen, Daan H M Creemers, Sanne P A Rasing, Filip Smit, Rutger C M E Engels
BACKGROUND: Since 2010, suicide has been the most important cause of mortality in youth aged 15 to 29 years in the Netherlands. Depression is an important risk factor for suicidal behaviors (i.e., suicide ideation, deliberate self-harm, planning, and suicide attempts) in adolescents. Adolescents who develop depressive symptoms, are also at risk for adult depression. This developmental continuity is especially noticeable in adolescents compared to other age groups; therefore, it is necessary to develop preventive strategies for teens...
May 10, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29740687/radioembolisation-in-europe-a-survey-amongst-cirse-members
#10
Margot T M Reinders, Etienne Mees, Maciej J Powerski, Rutger C G Bruijnen, Maurice A A J van den Bosch, Marnix G E H Lam, Maarten L J Smits
INTRODUCTION: Radioembolisation of liver tumours demands many choices from the physician regarding planning of treatment and subsequent follow-up. METHODS: An online questionnaire was distributed amongst all members of the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) to investigate the current state of radioembolisation practice. RESULTS: The survey was completed by 60 centres. The increasing number of radioembolisation procedures may reflect that radioembolisation is increasingly recognised as a valuable treatment option in European cancer guidelines...
May 8, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29739638/clinical-lymph-node-staging-in-colorectal-cancer-a-flip-of-the-coin
#11
Nelleke P M Brouwer, Rutger C H Stijns, Valery E P P Lemmens, Iris D Nagtegaal, Regina G H Beets-Tan, Jurgen J Fütterer, Pieter J Tanis, Rob H A Verhoeven, Johannes H W de Wilt
BACKGROUND: This study aims to provide insight in the quality of current daily practice in clinical lymph node staging in colorectal cancer (CRC) in the Netherlands. METHODS: Data of the nationwide population-based Netherlands Cancer Registry between 2003 and 2014 were used to analyze lymph node staging for cM0 CRC patients. Accuracy of clinical lymph node staging was calculated for the period 2011-2014. Analyses were performed for patients without preoperative treatment or treated with short-course radiotherapy (SCRT) followed by resection...
April 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29735510/isolated-ulnopalmar-dislocation-of-the-fifth-carpometacarpal-joint
#12
Stefan Beekhuizen, Pieter Bas de Witte, Marijn Rutgers, David Ohanis
Dislocations of the carpometacarpal (CMC) joints are uncommon and are frequently missed on standard radiographs of the hand. Dislocations could be dorsal or palmar; dorsal dislocations are seen more frequently. Palmar dislocations can be either ulnopalmar or radiopalmar. Stable CMC dislocations could be successfully treated conservatively, while unstable dislocations are mostly treated operatively. The purpose of this report is to present a patient with an isolated ulnopalmar dislocation of the fifth CMC joint, satisfactorily treated with closed reduction and casting...
May 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29727326/prognostic-impact-of-breast-conserving-therapy-versus-mastectomy-of-brca1-2-mutation-carriers-compared-with-noncarriers-in-a-consecutive-series-of-young-breast-cancer-patients
#13
Alexandra J van den Broek, Marjanka K Schmidt, Laura J van 't Veer, Hester S A Oldenburg, Emiel J Rutgers, Nicola S Russell, Vincent T H B M Smit, Adri C Voogd, Linetta B Koppert, Sabine Siesling, Jan J Jobsen, Pieter J Westenend, Flora E van Leeuwen, Rob A E M Tollenaar
OBJECTIVE: To investigate the effects of different types of surgery on breast cancer prognosis in germline BRCA1/BRCA2 mutation carriers compared with noncarriers. SUMMARY OF BACKGROUND DATA: Although breast-conserving therapy (breast-conserving surgery followed by radiotherapy) has been associated with more local recurrences than mastectomy, no differences in overall survival have been found in randomized trials performed in the general breast cancer population...
May 1, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29723923/a-humidifier-in-the-invasive-mode-during-non-invasive-respiratory-support-could-increase-condensation-and-thereby-impair-airway-patency
#14
Rutger C Flink, Anton H van Kaam, Frans H de Jongh
AIM: Humidifying non-invasively ventilated preterm infants is critical to prevent dehydration of respiratory mucosa, but over humidification can result in impaired airway patency and lung mechanics. This neonatal bench study investigated the humidity delivered using invasive and non-invasive humidification modes during nasal continuous positive airway pressure. METHODS: The study was conducted at the neonatal intensive care unit of Emma Children's Hospital, the Netherlands, in March 2014...
May 3, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29723005/a-new-coefficient-of-interrater-agreement-the-challenge-of-highly-unequal-category-proportions
#15
Rutger van Oest
We derive a general structure that encompasses important coefficients of interrater agreement such as the S-coefficient, Cohen's kappa, Scott's pi, Fleiss' kappa, Krippendorff's alpha, and Gwet's AC1. We show that these coefficients share the same set of assumptions about rater behavior; they only differ in how the unobserved category proportions are estimated. We incorporate Bayesian estimates of the category proportions and propose a new agreement coefficient with uniform prior beliefs. To correct for guessing in the process of item classification, the new coefficient emphasizes equal category probabilities if the observed frequencies are unstable due to a small sample, and the frequencies increasingly shape the coefficient as they become more stable...
May 3, 2018: Psychological Methods
https://www.readbyqxmd.com/read/29714998/polycyclic-sulfoximines-as-new-scaffolds-for-drug-discovery
#16
Mark L G Borst, Cécile M J Ouairy, Sander C Fokkema, Alessandro Cecchi, Jessica M C A Kerckhoffs, Vincent L de Boer, Peter J van den Boogaard, Rutger F Bus, Rijko Ebens, Rob van der Hulst, Joop Knol, Rob Libbers, Zhou M Lion, Bart W Settels, Ellen de Wever, Khaled A Attia, Piet-Jan Sinnema, Jesse M de Gooijer, Karen Harkema, Marieke Hazewinkel, Susan Snijder, Kees Pouwer
The design and synthesis of three novel and original polycyclic scaffolds containing sulfoximines is presented in this work, showing that sulfoximines represent a real opportunity for the discovery of new drug candidates. Additionally, the structures present at least two points of diversification and contain a high level of sp3-character, hence being very interesting 3D-scaffolds. The compounds synthesized were added to the compound collection of the European Lead Factory.
May 1, 2018: ACS Combinatorial Science
https://www.readbyqxmd.com/read/29704084/vera-lopez-complicated-lives-girls-parents-drugs-and-juvenile-justice-new-brunswick-nj-rutgers-university-press-2017-240pp-978-0-8135-8655-7
#17
Melissa Devorkin
No abstract text is available yet for this article.
April 27, 2018: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/29698048/how-the-tracking-of-habitual-rate-influences-speech-perception
#18
Merel Maslowski, Antje S Meyer, Hans Rutger Bosker
Listeners are known to track statistical regularities in speech. Yet, which temporal cues are encoded is unclear. This study tested effects of talker-specific habitual speech rate and talker-independent average speech rate (heard over a longer period of time) on the perception of the temporal Dutch vowel contrast /ɑ/-/a:/. First, Experiment 1 replicated that slow local (surrounding) speech contexts induce fewer long /a:/ responses than faster contexts. Experiment 2 tested effects of long-term habitual speech rate...
April 26, 2018: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/29696188/predicting-enrollment-performance-of-investigational-centers-in-phase-iii-multi-center-clinical-trials
#19
Rutger M van den Bor, Diederick E Grobbee, Bas J Oosterman, Petrus W J Vaessen, Kit C B Roes
Failure to meet subject recruitment targets in clinical trials continues to be a widespread problem with potentially serious scientific, logistical, financial and ethical consequences. On the operational level, enrollment-related issues may be mitigated by careful site selection and by allocating monitoring or training resources proportionally to the anticipated risk of poor enrollment. Such procedures require estimates of the expected recruitment performance that are sufficiently reliable to allow centers to be sensibly categorized...
September 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29692632/thrombocytopenia-and-bleeding-in-myelosuppressed-transfusion-dependent-patients-a-simulation-study-exploring-underlying-mechanisms
#20
Rutger A Middelburg, Jean-Louis H Kerkhoffs, Johanna G van der Bom
Background: Hematology-oncology patients often become severely thrombocytopenic and receive prophylactic platelet transfusions when their platelet count drops below 10×109 platelets/L. This so-called "platelet count trigger" of 10×109 platelets/L is recommended because currently available evidence suggests this is the critical concentration at which bleeding risk starts to increase. Yet, exposure time and lag time may have biased the results of studies on the association between platelet counts and bleeding risks...
2018: Clinical Epidemiology
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