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https://www.readbyqxmd.com/read/28437378/risk-factors-for-pediatric-extubation-failure-the-importance-of-respiratory-muscle-strength
#1
Robinder G Khemani, Tro Sekayan, Justin Hotz, Rutger C Flink, Gerrard F Rafferty, Narayan Iyer, Christopher J L Newth
OBJECTIVE: Respiratory muscle weakness frequently develops during mechanical ventilation, although in children there are limited data about its prevalence and whether it is associated with extubation outcomes. We sought to identify risk factors for pediatric extubation failure, with specific attention to respiratory muscle strength. DESIGN: Secondary analysis of prospectively collected data. SETTING: Tertiary care PICU. PATIENTS: Four hundred nine mechanically ventilated children...
April 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28432871/mir-24-3p-is-overexpressed-in-hodgkin-lymphoma-and-protects-hodgkin-and-reed-sternberg-cells-from-apoptosis
#2
Ye Yuan, Joost Kluiver, Jasper Koerts, Debora de Jong, Bea Rutgers, Fazlyn Reeny Abdul Razak, Martijn Terpstra, Boudewijn Plaat, Ilja M Nolte, Arjan Diepstra, Lydia Visser, Klaas Kok, Anke van den Berg
miRNAs play important roles in biological processes, such as proliferation, metabolism, differentiation, and apoptosis, whereas altered expression levels contribute to diseases, such as cancers. We identified miRNAs with aberrant expression in Hodgkin lymphoma (HL) and investigated their role in pathogenesis. Small RNA sequencing revealed 84 significantly differentially expressed miRNAs in HL cell lines as compared to germinal center B cells. Three up-regulated miRNAs-miR-23a-3p, miR-24-3p, and miR-27a-3p-were derived from one primary miRNA transcript...
April 19, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28430868/most-visualization-software-for-producing-automated-textbook-style-maps-of-genome-scale-metabolic-networks
#3
James J Kelley, Shay Maor, Min Kyung Kim, Anatoliy Lane, Desmond S Lun
Summary: Visualization of metabolites, reactions and pathways in genome-scale metabolic networks (GEMs) can assist in understanding cellular metabolism. Three attributes are desirable in software used for visualizing GEMs: 1. automation, since GEMs can be quite large; 2. production of understandable maps that provide ease in identification of pathways, reactions, and metabolites; and 3. visualization of the entire network to show how pathways are interconnected. No software currently exists for visualizing GEMs that satisfies all three characteristics, but MOST-Visualization, an extension of the software package MOST (Metabolic Optimization and Simulation Tool), satisfies (1), and by using a pre-drawn overview map of metabolism based on the Roche map satisfies (2) and comes close to satisfying (3)...
April 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28429479/dental-geriatrics-and-periodontitis
#4
REVIEW
Gösta Rutger Persson
The present literature review is focused on two main areas: (i) periodontal conditions in older individuals; and (ii) the scientific data available on periodontal treatment outcomes in individuals ≥ 75 years of age. The population of older people is increasing but the data on periodontal therapies and their efficacy in this population are limited and need to be carefully reviewed. Although life expectancy has increased, this does not mean that older people are medically healthy. Several chronic systemic diseases are associated with periodontitis, and the prevalence of most chronic diseases increases with age...
June 2017: Periodontology 2000
https://www.readbyqxmd.com/read/28428166/vascular-cognitive-impairment-in-a-memory-clinic-population-rationale-and-design-of-the-utrecht-amsterdam-clinical-features-and-prognosis-in-vascular-cognitive-impairment-trace-vci-study
#5
EDITORIAL
Jooske Marije Funke Boomsma, Lieza Geertje Exalto, Frederik Barkhof, Esther van den Berg, Jeroen de Bresser, Rutger Heinen, Huiberdina Lena Koek, Niels Daniël Prins, Philip Scheltens, Henry Chanoch Weinstein, Wiesje Maria van der Flier, Geert Jan Biessels
BACKGROUND: Vascular Cognitive Impairment (VCI) refers to cognitive dysfunction due to vascular brain injury, as a single cause or in combination with other, often neurodegenerative, etiologies. VCI is a broad construct that captures a heterogeneous patient population both in terms of cognitive and noncognitive symptoms and in terms of etiology and prognosis. This provides a challenge when applying this construct in clinical practice. OBJECTIVE: This paper presents the rationale and design of the TRACE-VCI study, which investigates the clinical features and prognosis of VCI in a memory clinic setting...
April 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28421030/cluster-analysis-to-identify-possible-subgroups-in-tinnitus-patients
#6
Minke J C van den Berge, Rolien H Free, Rosemarie Arnold, Emile de Kleine, Rutger Hofman, J Marc C van Dijk, Pim van Dijk
INTRODUCTION: In tinnitus treatment, there is a tendency to shift from a "one size fits all" to a more individual, patient-tailored approach. Insight in the heterogeneity of the tinnitus spectrum might improve the management of tinnitus patients in terms of choice of treatment and identification of patients with severe mental distress. The goal of this study was to identify subgroups in a large group of tinnitus patients. METHODS: Data were collected from patients with severe tinnitus complaints visiting our tertiary referral tinnitus care group at the University Medical Center Groningen...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28412587/accuracy-of-the-online-prognostication-tools-predict-and-adjuvant-for-early-stage-breast-cancer-patients-younger-than-50-years
#7
Ellen G Engelhardt, Alexandra J van den Broek, Sabine C Linn, Gordon C Wishart, Emiel J Th Rutgers, Anthonie O van de Velde, Vincent T H B M Smit, Adri C Voogd, Sabine Siesling, Mariël Brinkhuis, Caroline Seynaeve, Pieter J Westenend, Anne M Stiggelbout, Rob A E M Tollenaar, Flora E van Leeuwen, Laura J van 't Veer, Peter M Ravdin, Paul D P Pharaoh, Marjanka K Schmidt
IMPORTANCE: Online prognostication tools such as PREDICT and Adjuvant! are increasingly used in clinical practice by oncologists to inform patients and guide treatment decisions about adjuvant systemic therapy. However, their validity for young breast cancer patients is debated. OBJECTIVE: To assess first, the prognostic accuracy of PREDICT's and Adjuvant! 10-year all-cause mortality, and second, its breast cancer-specific mortality estimates, in a large cohort of breast cancer patients diagnosed <50 years...
April 13, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28412468/a-computationally-simply-central-monitoring-procedure-was-proposed-and-effectively-applied-to-empirical-trial-data-with-known-fraud
#8
Rutger M van den Bor, Petrus Wj Vaessen, Bas J Oosterman, Nicolaas Pa Zuithoff, Diederick E Grobbee, Kit Cb Roes
OBJECTIVE: Central monitoring of multi-center clinical trials becomes an ever more feasible quality assurance tool, in particular for the detection of data fabrication. More widespread application, across both industry-sponsored as well as academic clinical trials, requires central monitoring methodologies that are both effective and relatively simple in implementation. STUDY DESIGN AND SETTING: We describe a computationally simple fraud detection procedure intended to be applied repeatedly and (semi-)automatically to accumulating baseline data, to detect data fabrication in multi-center trials as early as possible...
April 12, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28411255/absence-of-the-spleen-and-the-occurrence-of-primary-red-cell-alloimmunization-in-humans
#9
Dorothea Evers, Johanna G van der Bom, Janneke Tijmensen, Masja de Haas, Rutger A Middelburg, Karen M K de Vooght, Daan van de Kerkhof, Otto Visser, Nathalie C V Péquériaux, Francisca Hudig, Jaap Jan Zwaginga
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April 14, 2017: Haematologica
https://www.readbyqxmd.com/read/28408763/silicon-solar-cells-on-glass-with-power-conversion-efficiency-above-13-at-thickness-below-15-micrometer
#10
Paul Sonntag, Natalie Preissler, Matevž Bokalič, Martina Trahms, Jan Haschke, Rutger Schlatmann, Marko Topič, Bernd Rech, Daniel Amkreutz
Liquid phase crystallized silicon on glass with a thickness of (10-40) μm has the potential to reduce material costs and the environmental impact of crystalline silicon solar cells. Recently, wafer quality open circuit voltages of over 650 mV and remarkable photocurrent densities of over 30 mA/cm(2) have been demonstrated on this material, however, a low fill factor was limiting the performance. In this work we present our latest cell progress on 13 μm thin poly-crystalline silicon fabricated by the liquid phase crystallization directly on glass...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28401426/high-rates-of-return-to-sports-activities-and-work-after-osteotomies-around-the-knee-a-systematic-review-and-meta-analysis
#11
REVIEW
Alexander Hoorntje, Suzanne Witjes, P Paul F M Kuijer, Koen L M Koenraadt, Rutger C I van Geenen, Joost G Daams, Alan Getgood, Gino M M J Kerkhoffs
BACKGROUND: Knee osteotomies are proven treatment options, especially in younger patients with unicompartmental knee osteoarthritis, for certain cases of chronic knee instability, or as concomitant treatment for meniscal repair or transplantation surgery. Presumably, these patients wish to stay active. Data on whether these patients return to sport (RTS) activities and return to work (RTW) are scarce. OBJECTIVES: Our aim was to systematically review (1) the extent to which patients can RTS and RTW after knee osteotomy and (2) the time to RTS and RTW...
April 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28398873/predictors-of-knowledge-and-image-interpretation-skill-development-in-radiology-residents
#12
Cécile J Ravesloot, Marieke F van der Schaaf, Cas L J J Kruitwagen, Anouk van der Gijp, Dirk R Rutgers, Cees Haaring, Olle Ten Cate, Jan P J van Schaik
Purpose To investigate knowledge and image interpretation skill development in residency by studying scores on knowledge and image questions on radiology tests, mediated by the training environment. Materials and Methods Ethical approval for the study was obtained from the ethical review board of the Netherlands Association for Medical Education. Longitudinal test data of 577 of 2884 radiology residents who took semiannual progress tests during 5 years were retrospectively analyzed by using a nonlinear mixed-effects model taking training length as input variable...
April 11, 2017: Radiology
https://www.readbyqxmd.com/read/28388963/minimally-invasive-versus-open-distal-pancreatectomy-leopard-study-protocol-for-a-randomized-controlled-trial
#13
Thijs de Rooij, Jony van Hilst, Jantien A Vogel, Hjalmar C van Santvoort, Marieke T de Boer, Djamila Boerma, Peter B van den Boezem, Bert A Bonsing, Koop Bosscha, Peter-Paul Coene, Freek Daams, Ronald M van Dam, Marcel G Dijkgraaf, Casper H van Eijck, Sebastiaan Festen, Michael F Gerhards, Bas Groot Koerkamp, Jeroen Hagendoorn, Erwin van der Harst, Ignace H de Hingh, Cees H Dejong, Geert Kazemier, Joost Klaase, Ruben H de Kleine, Cornelis J van Laarhoven, Daan J Lips, Misha D Luyer, I Quintus Molenaar, Vincent B Nieuwenhuijs, Gijs A Patijn, Daphne Roos, Joris J Scheepers, George P van der Schelling, Pascal Steenvoorde, Rutger-Jan Swijnenburg, Jan H Wijsman, Moh'd Abu Hilal, Olivier R Busch, Marc G Besselink
BACKGROUND: Observational cohort studies have suggested that minimally invasive distal pancreatectomy (MIDP) is associated with better short-term outcomes compared with open distal pancreatectomy (ODP), such as less intraoperative blood loss, lower morbidity, shorter length of hospital stay, and reduced total costs. Confounding by indication has probably influenced these findings, given that case-matched studies failed to confirm the superiority of MIDP. This accentuates the need for multicenter randomized controlled trials, which are currently lacking...
April 8, 2017: Trials
https://www.readbyqxmd.com/read/28385356/the-promus-premier-everolimus-eluting-platinum-chromium-stent-with-durable-polymer-evaluated-in-a-real-world-all-comer-population-in-rotterdam-cardiology-hospital-the-p-search-registry
#14
Miguel E Lemmert, Nicolas M van Mieghem, Robert-Jan van Geuns, Roberto Diletti, Rutger J van Bommel, Ron T van Domburg, Peter P de Jaegere, Evelyn Regar, Felix Zijlstra, Eric Boersma, Joost Daemen
BACKGROUND: A new-generation everolimus eluting platinum-chromium stent (EePCS), offering improved radial strength, radiopacity and conformability compared to everolimus-eluting cobalt-chromium stents (EeCCS), was evaluated with regard to safety and efficacy in an all-comer cohort. METHODS: A total of 1000 consecutive all-comer patients (including acute coronary syndrome, multivessel disease, calcified lesions) treated with an EePCS (Promus Premier™, Boston Scientific, Natick, Massachusetts) from May 2013 to October 2014 were compared to 1000 consecutive patients treated with an EeCCS (Xience Prime™, Abbott Vascular, Santa Clara, California) from April 2012 to May 2013...
March 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28375855/cause-specific-mortality-in-a-population-based-cohort-of-9799-women-treated-for-ductal-carcinoma-in-situ
#15
Lotte E Elshof, Marjanka K Schmidt, Emiel J Th Rutgers, Flora E van Leeuwen, Jelle Wesseling, Michael Schaapveld
OBJECTIVE: To assess cause-specific mortality in women treated for ductal carcinoma in situ (DCIS). BACKGROUND: From screening and treatment perspective, it is relevant to weigh the low breast cancer mortality after DCIS against mortality from other causes and expected mortality in the general population. METHODS: We conducted a population-based cohort study comprising 9799 Dutch women treated for primary DCIS between 1989 and 2004 and estimated standardized mortality ratios (SMRs)...
April 3, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28369513/identification-and-characterization-of-aurora-kinase-b-and-c-variants-associated-with-maternal-aneuploidy
#16
Alexandra L Nguyen, Diego Marin, Anbo Zhou, Amanda S Gentilello, Evan M Smoak, Zubing Cao, Anastasia Fedick, Yujue Wang, Deanne Taylor, Richard T Scott, Jinchuan Xing, Nathan Treff, Karen Schindler
STUDY QUESTION: Are single nucleotide variants (SNVs) in Aurora kinases B and C associated with risk of aneuploid conception? SUMMARY ANSWER: Two SNVs were found in patients with extreme aneuploid concepti rates with respect to their age; one variant, AURKC p.I79V, is benign, while another, AURKB p.L39P, is a potential gain-of-function mutant with increased efficiency in promoting chromosome alignment. WHAT IS KNOWN ALREADY: Maternal age does not always predict aneuploidy risk, and rare gene variants can be drivers of disease...
March 25, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28363820/ventricular-fibrillation-waveform-characteristics-of-the-surface-ecg-impact-of-the-left-ventricular-diameter-and-mass
#17
Judith L Bonnes, Jos Thannhauser, Joris Nas, Sjoerd W Westra, Rutger M G Jansen, Gjerrit Meinsma, Menko-Jan de Boer, Joep L R M Smeets, Wessel Keuper, Marc A Brouwer
BACKGROUND: Despite a promising association between VF waveform characteristics and prognosis after resuscitation, studies with VF-guided treatment have so far not improved outcomes. While driven by the idea that the VF waveform reflects arrest duration, increasing evidence suggests that pre-existent disease-related changes of the myocardium affect ECG-characteristics of VF as well. In this context, we studied the impact of the left ventricular (LV) diameter and mass. METHODS: Cohort of 193 ICD-patients with defibrillation testing at the Radboudumc (2010-2014)...
March 29, 2017: Resuscitation
https://www.readbyqxmd.com/read/28353623/preoperative-ct-assessment-in-ci-dehiscence-of-the-labyrinthine-segment-of-the-facial-nerve-causing-facial-nerve-stimulation
#18
Lieke van der Meer, Rutger Hofman, Rolien Free
No abstract text is available yet for this article.
March 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28347496/spatial-patterns-in-coastal-lagoons-related-to-the-hydrodynamics-of-seawater-intrusion
#19
Annie Fiandrino, Vincent Ouisse, Franck Dumas, Franck Lagarde, Romain Pete, Nathalie Malet, Sandrine Le Noc, Rutger de Wit
Marine intrusion was simulated in a choked and in a restricted coastal lagoon by using a 3D-hydrodynamic model. To study the spatiotemporal progression of seawater intrusion and its mixing efficiency with lagoon waters we define Marine Mixed Volume (VMM) as a new hydrodynamic indicator. Spatial patterns in both lagoons were described by studying the time series and maps of VMM taking into account the meteorological conditions encountered during a water year. The patterns comprised well-mixed zones (WMZ) and physical barrier zones (PBZ) that act as hydrodynamic boundaries...
March 24, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28347308/erratum-to-assessment-of-myocardial-injury-after-reperfused-infarction-by-t1%C3%AF-cardiovascular-magnetic-resonance
#20
Rutger H Stoffers, Marie Madden, Mohammed Shahid, Francisco Contijoch, Joseph Solomon, James J Pilla, Joseph H Gorman, Robert C Gorman, Walter R T Witschey
No abstract text is available yet for this article.
March 27, 2017: Journal of Cardiovascular Magnetic Resonance
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