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Yuli R Tak, Steven M Brunwasser, Anna Lichtwarck-Aschoff, Rutger C M E Engels
Over the course of adolescence, an increasing number of adolescents experience depression. In order to effectively target depression, identifying risk factors for depressive symptoms is pivotal. Since low levels of self-efficacy were associated with higher levels of depressive symptoms in previous studies, the current study investigated the bidirectional and prospective associations between depressive symptoms and academic, social and emotional self-efficacy from early to mid adolescence in a cross-lagged path model...
November 29, 2016: Journal of Youth and Adolescence
Annemieke S Littooij, Thomas C Kwee, Goya Enríquez, Jonathan I M L Verbeke, Claudio Granata, Auke Beishuizen, Charlotte de Lange, Floriana Zennaro, Marrie C A Bruin, Rutger A J Nievelstein
Osteonecrosis is a well-recognized complication in patients treated with corticosteroids. The incidence of osteonecrosis in children treated for Hodgkin lymphoma is unknown because prospective whole-body magnetic resonance imaging (MRI) studies are lacking in this patient population. Paediatric patients with newly diagnosed Hodgkin lymphoma who were treated according to a uniform paediatric Hodgkin protocol were eligible for inclusion in this prospective study. Whole-body MRI was performed in all 24 included patients (mean age 15·1 years, 12 girls) both before treatment and after 2 cycles of chemotherapy, and in 16 patients after completion of chemotherapy...
November 28, 2016: British Journal of Haematology
Ronny Wickström, Åsa Fowler, Gordana Bogdanovic, Rutger Bennet, Margareta Eriksson
AIM: Encephalitis is a rare, serious condition and anti-viral therapies, increased knowledge of inflammatory pathways and improved diagnostics have increased the therapeutic possibilities. We describe 40 years of childhood encephalitis in Sweden, covering the diagnostics, aetiology and outcomes. METHODS: We reviewed the clinical data that was available for all children discharged from the Karolinska University Hospital in Stockholm following treatment for encephalitis from 1970-2009...
November 25, 2016: Acta Paediatrica
Lotte E Elshof, Michael Schaapveld, Marjanka K Schmidt, Emiel J Rutgers, Flora E van Leeuwen, Jelle Wesseling
No abstract text is available yet for this article.
November 23, 2016: Breast Cancer Research and Treatment
Rutger Verbeek, Marjorie Boyer, S Matthijs Boekholdt, G Kees Hovingh, John J P Kastelein, Nicholas Wareham, Kay-Tee Khaw, Benoit J Arsenault
OBJECTIVE: Carriers of the PCSK9 (proprotein convertase subtilisin/kexin 9) R46L genetic variant (rs11591147) are characterized by low levels of low-density lipoprotein cholesterol and a decreased risk of cardiovascular disease. We studied the impact of the R46L variant on lipoprotein size and composition. APPROACH AND RESULTS: Lipoprotein size and composition were measured by nuclear magnetic resonance spectroscopy in 2373 participants of the EPIC (European Prospective Investigation into Cancer and Nutrition)-Norfolk study...
November 17, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Karlijn W J de Jonge-Heesen, Kim M van Ettekoven, Sanne P A Rasing, Farina H J Oprins-van Liempd, Ad A Vermulst, Rutger C M E Engels, Daan H M Creemers
BACKGROUND: Adolescents are at risk of developing depressive symptoms. Given the prevalence, recurrence and negative consequences of adolescent depression, it is crucial to implement prevention programs for high-risk adolescents. Prevention programs at an indicated level have shown to be successful in reducing depressive symptoms in adolescents. This study will evaluate the (cost)effectiveness of the prevention program 'Op Volle Kracht (OVK 2.0)' for adolescents with elevated depressive symptoms...
November 16, 2016: BMC Psychiatry
Tro Sekayan, Justin Hotz, Rutger Flink, Narayan Iyer, Christopher Newth, Robinder Khemani
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
S C Teixeira, B B Koolen, P H M Elkhuizen, M-J T F D Vrancken Peeters, M P M Stokkel, S Rodenhuis, V van der Noort, E J T Rutgers, R A Valdés Olmos
INTRODUCTION: (18)F-FDG PET/CT has high positive predictive value for the detection of avid lymph node metastases in breast cancer patients. We analysed the effect of upstaging lymph nodes by PET/CT on short-term outcome in stage II/III breast cancer patients. PATIENTS AND METHODS: A total of 278 stage II/III primary breast cancer patients (mean age 48.9 years, range 19-75 years) were re-staged with (18)F-FDG PET/CT before start of pre-operative systemic treatment (PST)...
October 31, 2016: European Journal of Surgical Oncology
Robert Hoehndorf, Mona Alshahrani, Georgios V Gkoutos, George Gosline, Quentin Groom, Thomas Hamann, Jens Kattge, Sylvia Mota de Oliveira, Marco Schmidt, Soraya Sierra, Erik Smets, Rutger A Vos, Claus Weiland
BACKGROUND: The systematic analysis of a large number of comparable plant trait data can support investigations into phylogenetics and ecological adaptation, with broad applications in evolutionary biology, agriculture, conservation, and the functioning of ecosystems. Floras, i.e., books collecting the information on all known plant species found within a region, are a potentially rich source of such plant trait data. Floras describe plant traits with a focus on morphology and other traits relevant for species identification in addition to other characteristics of plant species, such as ecological affinities, distribution, economic value, health applications, traditional uses, and so on...
November 14, 2016: Journal of Biomedical Semantics
Marion Kiewik, Joanne E L VanDerNagel, Rutger C M E Engels, Cor A DeJong
BACKGROUND AND AIMS: Adolescents with Intellectual Disability (ID) are at risk for tobacco and alcohol use, yet little or no prevention programs are available for this group. 'Prepared on time' is an e-learning program based on the attitude - social influence - efficacy model originally developed for fifth and sixth grades of mainstream primary schools. The goals of this study were (1) to examine the lifetime use of tobacco and alcohol among this target group and (2) to gain a first impression of the efficacy of 'Prepared on time' among 12-16-year old students with moderate or mild ID (MMID)...
November 8, 2016: Research in Developmental Disabilities
Emiel B M Spuesens, Rutger W W Brouwer, Kristin H J M Mol, Theo Hoogenboezem, Christel E M Kockx, Ruud Jansen, Wilfred F J Van IJcken, Annemarie M C Van Rossum, Cornelis Vink
Mycoplasma pneumoniae is a common cause of respiratory tract infections (RTIs) in children. We recently demonstrated that this bacterium can be carried asymptomatically in the respiratory tract of children. To identify potential genetic differences between M. pneumoniae strains that are carried asymptomatically and those that cause symptomatic infections, we performed whole-genome sequence analysis of 20 M. pneumoniae strains. The analyzed strains included 3 reference strains, 3 strains isolated from asymptomatic children, 13 strains isolated from clinically well-defined patients suffering from an upper (n = 4) or lower (n = 9) RTI, and one strain isolated from a follow-up patient who recently recovered from an RTI...
2016: Frontiers in Microbiology
Rutger W W Brouwer, Mirjam C G N van den Hout, Wilfred F J van IJcken, Eric Soler, Ralph Stadhouders
The development and widespread implementation of chromosome conformation capture (3C) technology has allowed unprecedented new insight into how chromosomes are folded in three-dimensional (3D) space. 3C and its derivatives have contributed tremendously to the now widely accepted view that genome topology plays an important role in many major cellular processes, at a chromosome-wide scale, but certainly also at the level of individual genetic loci. A particularly popular application of 3C technology is to study transcriptional regulation, allowing researchers to draw maps of gene regulatory connections beyond the linear genome through addition of the third dimension...
2017: Methods in Molecular Biology
Manon L A van Starrenburg, Rowella C M W Kuijpers, Marloes Kleinjan, Giel J M Hutschemaekers, Rutger C M E Engels
Childhood anxiety is a problem not only because of its negative consequences on the well-being of children but also because of its adverse effects on society and its role in mental disorders later in life. Adequate prevention might be the key in tackling this problem. The effectiveness of Coping Cat, as an indicated CBT-based prevention program in Dutch primary school children, was assessed by means of a randomized controlled trial. In total, 141 children aged 7-13 with elevated levels of anxiety and their mothers were included and randomly assigned to an intervention group and a waiting list control group...
November 8, 2016: Prevention Science: the Official Journal of the Society for Prevention Research
Nicolas Arnaud, Silke Diestelkamp, Lutz Wartberg, Peter-Michael Sack, Anne Daubmann, Rainer Thomasius
OBJECTIVES: The proportion of children and adolescents receiving emergency care for acute alcohol intoxication (AAI) in Germany has sharply increased over the past years. Despite this, no randomized controlled trials (RCTs) have studied guideline- and evidence-based interventions to prevent future alcohol misuse within this population. The objective of our investigation was to evaluate the effectiveness of a brief motivational intervention (b-MI) to reduce drinking and associated problems within pediatric emergency departments (PED) in Hamburg, Germany...
November 1, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Rutger Heinen, Willem H Bouvy, Adrienne M Mendrik, Max A Viergever, Geert Jan Biessels, Jeroen de Bresser
INTRODUCTION: Pooling of multicenter brain imaging data is a trend in studies on ageing related brain diseases. This poses challenges to MR-based brain segmentation. The performance across different field strengths of three widely used automated methods for brain volume measurements was assessed in the present study. METHODS: Ten subjects (mean age: 64 years) were scanned on 1.5T and 3T MRI on the same day. We determined robustness across field strength (i.e., whether measured volumes between 3T and 1...
2016: PloS One
Rutger A Middelburg, Hans Vrielink, Leendert Porcelijn
BACKGROUND: Fetal/Neonatal alloimmune neutropenia (FNAIN) is a serious condition usually resulting from immunisation of the mother to paternally inherited neutrophil antigens of the foetus. Understanding the biology of female immunisation against neutrophils could help predict or prevent FNAIN. OBJECTIVES: To quantify differences in the prevalence of specific and pan-reactive granulocyte antibodies, between allo-exposed and never allo-exposed male and female blood donors...
October 31, 2016: European Journal of Haematology
Göran Dahl, Stephan Steigele, Per Hillertz, Anna Tigerström, Anders Egnéus, Alexander Mehrle, Martin Ginkel, Fredrik Edfeldt, Geoff Holdgate, Nichole O'Connell, Bernd Kappler, Annette Brodte, Philip B Rawlins, Gareth Davies, Eva-Lotta Westberg, Rutger H A Folmer, Stephan Heyse
Surface plasmon resonance (SPR) is a powerful method for obtaining detailed molecular interaction parameters. Modern instrumentation with its increased throughput has enabled routine screening by SPR in hit-to-lead and lead optimization programs, and SPR has become a mainstream drug discovery technology. However, the processing and reporting of SPR data in drug discovery are typically performed manually, which is both time-consuming and tedious. Here, we present the workflow concept, design and experiences with a software module relying on a single, browser-based software platform for the processing, analysis, and reporting of SPR data...
October 27, 2016: Journal of Biomolecular Screening
Pablo Borrelli, Maarten L Donswijk, Marcel P Stokkel, Suzana C Teixeira, Harm van Tinteren, Emiel J Th Rutgers, Renato A Valdés Olmos
BACKGROUND: In recent years repeat sentinel node (SN) biopsy has been proven to be feasible in local breast cancer recurrence (LBCR). However, in these patients SNs outside the ipsilateral axilla are frequently observed. This study evaluates the contribution of SPECT/CT for SN localization and surgical adjustment in LBCR patients. METHODS: SN biopsy was performed in 122 LBCR patients (median age 60.5 years, range 24-87), enrolled from August 2006 to July 2015. Median disease-free time lapse was 109...
October 27, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Andor F van den Hoven, Jip F Prince, Rutger C G Bruijnen, Helena M Verkooijen, Gerard C Krijger, Marnix G E H Lam, Maurice A A J van den Bosch
BACKGROUND: An anti-reflux catheter (ARC) may increase the tumor absorbed dose during radioembolization (RE) by elimination of particle reflux and its effects on hemodynamics. Since the catheter is fixed in a centro-luminal position, it may also increase the predictive accuracy of a scout dose administration before treatment. The purpose of the SIM trial is to compare the effects of ARC use during RE with holmium-166 ((166)Ho) microspheres in patients with colorectal liver metastases (CRLM), with the use of a standard end-hole microcatheter...
October 25, 2016: Trials
Rutger M J de Zoete, Peter G Osmotherly, Darren A Rivett, Scott F Farrell, Suzanne J Snodgrass
OBJECTIVE: To (1) identify reported tests used to assess sensorimotor control in individuals with idiopathic neck pain and (2) investigate whether these test can quantify differences between individuals with idiopathic neck pain and healthy individuals. DATA SOURCES: Databases AMED, CINAHL, Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, PEDro, SCOPUS and SportDiscus. STUDY SELECTION: Studies reporting sensorimotor outcomes in individuals with idiopathic neck pain or healthy individuals were identified...
October 19, 2016: Archives of Physical Medicine and Rehabilitation
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