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https://www.readbyqxmd.com/read/28929359/immunohistochemical-versus-molecular-blueprint-and-mammaprint-subtyping-of-breast-carcinoma-outcome-results-from-the-eortc-10041-big-3-04-mindact-trial
#1
G Viale, F A de Snoo, L Slaets, J Bogaerts, L van 't Veer, E J Rutgers, M J Piccart-Gebhart, L Stork-Sloots, A Glas, L Russo, P Dell'Orto, K Tryfonidis, S Litière, F Cardoso
PURPOSE: This study compares immunohistochemical (IHC) versus molecular subtyping (BluePrint and MammaPrint) in the population of patients enrolled in MINDACT and outcome based on molecular subtyping (MS) versus surrogate pathological subtyping (PS) as defined by the 2013 St. Gallen guidelines. METHODS: MS classified patients in the following subtypes: Luminal A, Luminal B, HER-2-, and Basal-type. IHC/FISH for pathological subtyping (ER, PgR, HER-2, and Ki67) was centrally assessed in the European Institute of Oncology (n = 5806)...
September 19, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28927373/variation-in-loss-of-immunity-shapes-influenza-epidemics-and-the-impact-of-vaccination
#2
Rutger G Woolthuis, Jacco Wallinga, Michiel van Boven
BACKGROUND: Protective antibody immunity against the influenza A virus wanes in 2-7 years due to antigenic drift of the virus' surface proteins. The duration of immune protection is highly variable because antigenic evolution of the virus is irregular. Currently, the variable nature of the duration of immunity has had little attention in analyses of the impact of vaccination, including cost-effectiveness studies. METHODS: We developed a range of mathematical transmission models to investigate the effect of variable duration of immunity on the size of seasonal epidemics...
September 19, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28922787/optimal-duration-of-extended-adjuvant-endocrine-therapy-for-early-breast-cancer-results-of-the-ideal-trial-boog-2006-05
#3
Erik J Blok, Judith R Kroep, Elma Meershoek-Klein Kranenbarg, Marjolijn Duijm-de Carpentier, Hein Putter, Joan van den Bosch, Eduard Maartense, A Elise van Leeuwen-Stok, Gerrit-Jan Liefers, Johan W R Nortier, Emiel J Th Rutgers, Cornelis J H van de Velde
Background: The optimal duration of extended endocrine therapy beyond five years after initial aromatase inhibitor-based adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer is still unknown. Therefore, we conducted a clinical trial to compare two different extended endocrine therapy durations. Methods: In the randomized phase III IDEAL trial, postmenopausal patients with hormone receptor-positive breast cancer were randomly allocated to either 2...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28916623/efficacy-of-radioembolization-with-holmium-166-microspheres-in-salvage-patients-with-liver-metastases-a-phase-2-study
#4
Jip F Prince, Maurice A A J van den Bosch, J F W Nijsen, Maarten L J Smits, Andor F van den Hoven, Stavros Nikolakopoulos, Frank J Wessels, Rutger C G Bruijnen, Manon Braat, Bernard A Zonnenberg, Marnix Lam
Rationale: Radioembolization of liver malignancies with holmium-166 (166Ho) microspheres has been shown safe in a phase 1 dose-escalation study. The purpose of this study was to investigate the efficacy of 166Ho radioembolization. Methods: In this prospective single-arm study, 56 patients were enrolled, all with liver metastases refractory to systemic therapy and ineligible for surgical resection. Radioembolization was performed with a projected average absorbed dose of 60 Gy to the liver (equal to 3.8 GBq/kg liver tissue)...
September 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28915633/selection-of-optimal-molecular-targets-for-tumor-specific-imaging-in-pancreatic-ductal-adenocarcinoma
#5
Willemieke S Tummers, Arantza Farina-Sarasqueta, Martin C Boonstra, Hendrica A Prevoo, Cornelis F Sier, Jan S Mieog, Johannes Morreau, Casper H van Eijck, Peter J Kuppen, Cornelis J van de Velde, Bert A Bonsing, Alexander L Vahrmeijer, Rutger-Jan Swijnenburg
Discrimination of pancreatic ductal adenocarcinoma (PDAC) from chronic pancreatitis (CP) or peritumoral inflammation is challenging, both at preoperative imaging and during surgery, but it is crucial for proper therapy selection. Tumor-specific molecular imaging aims to enhance this discrimination and to help select and stratify patients for resection. We evaluated various biomarkers for the specific identification of PDAC and associated lymph node metastases. Using immunohistochemistry (IHC), expression levels and patterns were investigated of integrin αvβ6, carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), Cathepsin E (Cath E), epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), thymocyte differentiation antigen 1 (Thy1), and urokinase-type plasminogen activator receptor (uPAR)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28904079/ascorbic-acid-promotes-a-tgf%C3%AE-1-induced-myofibroblast-phenotype-switch
#6
Bram Piersma, Olaf Y Wouters, Saskia de Rond, Miriam Boersema, Rutger A F Gjaltema, Ruud A Bank
l-Ascorbic acid (AA), generally known as vitamin C, is a crucial cofactor for a variety of enzymes, including prolyl-3-hydroxylase (P3H), prolyl-4-hydroxylase (P4H), and lysyl hydroxylase (LH)-mediated collagen maturation. Here, we investigated whether AA has additional functions in the regulation of the myofibroblast phenotype, besides its function in collagen biosynthesis. We found that AA positively influences TGFβ1-induced expression of COL1A1, ACTA2, and COL4A1 Moreover, we demonstrated that AA promotes αSMA stress fiber formation as well as the synthesis and deposition of collagens type I and IV Additionally, AA amplified the contractile phenotype of the myofibroblasts, as seen by increased contraction of a 3D collagen lattice...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28902778/incidences-of-pancreatic-malignancy-and-mortality-in-patients-with-untreated-branch-duct-intraductal-papillary-mucinous-neoplasms-undergoing-surveillance-a-systematic-review
#7
Rutger J Lensing, Shandra Bipat
OBJECTIVE: The aim of this study was to pool incidences of increased cyst size, malignant branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs), pancreatic malignancy, and pancreatic malignancy-related death during follow-up (FU) of BD-IPMN patients. METHODS: Searches were performed from January 2010 to April 2016. All hits were checked on inclusion criteria, and outcomes were extracted. Incidences were pooled. Three subgroups were defined: (1) including only BD-IPMN patients, (2) short-interval FU (maximum 6 months), and (3) long-interval FU (>6 months)...
October 2017: Pancreas
https://www.readbyqxmd.com/read/28885519/preparing-global-trauma-nurses-for-leadership-roles-in-global-trauma-systems
#8
Sol Angelica Muñiz, Richard W Lang, Lisa Falcon, Jasmine Garces-King, Suzanne Willard, Gregory L Peck
Trauma leads to 5.7 million annual deaths globally, accounting for 25%-33% of global unintentional deaths and 90% of the global trauma burden in low- and middle-income countries. The Lancet Commission on Global Surgery and the World Health Organization assert that emergent and essential surgical capacity building and trauma system improvement are essential to address the global burden of trauma. In response, the Rutgers Global Surgery program, the School of Nursing and Medicine, and the Robert Wood Johnson University Hospital faculty collaborated in the first Interprofessional Models in Global Injury Care and Education Symposium in June 2016...
September 2017: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/28882509/clinical-benefits-of-joint-mobilisation-on-ankle-sprains-a-systematic-review-and-meta-analysis
#9
REVIEW
Ishanka Weerasekara, Peter Osmotherly, Suzanne Snodgrass, Jodie Marquez, Rutger de Zoete, Darren A Rivett
OBJECTIVE: To assess the clinical benefits of joint mobilisation on ankle sprains. DATA SOURCES: MEDLINE, MEDLINE In Process, Embase, AMED, PsycINFO, CINAHL, Cochrane library, PEDro, Scopus, SPORTDiscus and Dissertations and Thesis were searched from inception to June, 2017. STUDY SELECTION: Studies investigating humans with a grade I or II lateral or medial sprains of the ankle in any pathological state from acute to chronic, who had been treated with joint mobilisation were considered for inclusion...
September 4, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28875560/not-changes-in-membrane-fluidity-but-proteotoxic-stress-triggers-heat-shock-protein-expression-in-chlamydomonas-reinhardtii
#10
Mark Rütgers, Ligia Segatto Muranaka, Miriam Schulz-Raffelt, Sylvia Thoms, Juliane Schurig, Felix Willmund, Michael Schroda
A conserved reaction of all organisms exposed to heat stress is an increased expression of heat shock proteins (HSPs). Several studies have proposed that HSP expression in heat-stressed plant cells is triggered by an increased fluidity of the plasma membrane. Among the main lines of evidence in support of this model are (i) the degree of membrane lipid saturation was higher in cells grown at elevated temperatures and correlated with a lower amplitude of HSP expression upon a temperature upshift; (ii) membrane fluidizers induce HSP expression at physiological temperatures; (iii) membrane rigidifier dimethylsulfoxide dampens heat-induced HSP expression...
September 6, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28871564/redefining-the-positive-margin-in-pancreatic-cancer-impact-on-patterns-of-failure-long-term-survival-and-adjuvant-therapy
#11
Arsen Osipov, Nicholas Nissen, Joanne Rutgers, Deepti Dhall, Jason Naziri, Shefali Chopra, Quanlin Li, Andrew Eugene Hendifar, Richard Tuli
PURPOSE: There is debate regarding the definition and clinical significance of margin clearance in pancreatic ductal adenocarcinoma (PDA). A comprehensive archival analysis of surgical resection margins was performed to determine the effect on locoregional recurrence and survival, and the impact of adjuvant therapy in PDA. METHODS: We identified 105 patients with resected PDA. Pancreatic, anterior, bile duct, and posterior surgical resection margins (PM; posterior surface, uncinate and vascular groove) were identified...
September 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28871322/frequency-and-characteristics-of-pulmonary-nodules-in-children-at-computed-tomography
#12
Atia Samim, Annemieke S Littooij, Marry M van den Heuvel-Eibrink, Frank J Wessels, Rutger A J Nievelstein, Pim A de Jong
BACKGROUND: Normative data on pulmonary nodules in children without malignancy are limited. Knowledge of the frequency and characteristics of pulmonary nodules in healthy children can influence care decisions in children with malignant disease. OBJECTIVE: To provide normative data concerning the frequency and characteristics of pulmonary nodules on computed tomography (CT) in young children. MATERIALS AND METHODS: All children ages 1 year-12 years who underwent chest CT after high-energy trauma were retrospectively investigated...
September 4, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28854078/changes-in-treatment-patterns-and-incremental-health-care-utilization-due-to-p2y12-associated-complications-in-patients-with-acute-coronary-syndrome
#13
Ami Vyas, Lori D Bash, Mehul D Patel, Ross J Simpson
BACKGROUND: P2Y12 antiplatelet therapy (APT) is highly efficacious in reducing the incidence of ischemic events in patients with acute coronary syndrome (ACS); however, it is associated with several adverse complications. Data on P2Y12-associated complications and adherence to APT are sparse. OBJECTIVE: To describe the characteristics, frequency of P2Y12-associated complications, adherence and persistence to P2Y12 APT, and health care utilization among ACS patients on P2Y12 APT...
September 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28844015/impact-of-gene-expression-profiling-in-patients-with-early-breast-cancer-when-applied-outside-the-guideline-directed-indication-area
#14
K Schreuder, A Kuijer, E J Th Rutgers, C H Smorenburg, Th van Dalen, S Siesling
PURPOSE: In Dutch guidelines, gene expression profiles (GEP) are indicated in estrogen receptor positive early breast cancer patients in whom benefit of chemotherapy (CT) is uncertain based on traditional prognostic factors alone. Aim of the present study is to assess the use and impact of GEP on administration of adjuvant CT in breast cancer patients who have according to national guidelines a clear indication to either use or withhold adjuvant chemotherapy (clinical high or low risk)...
August 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28838210/de-escalating-and-escalating-treatments-for-early-stage-breast-cancer-the-st-gallen-international-expert-consensus-conference-on-the-primary-therapy-of-early-breast-cancer-2017
#15
G Curigliano, H J Burstein, E P Winer, M Gnant, P Dubsky, S Loibl, M Colleoni, M M Regan, M Piccart-Gebhart, H-J Senn, B Thürlimann, F André, J Baselga, J Bergh, H Bonnefoi, S Y Brucker, F Cardoso, L Carey, E Ciruelos, J Cuzick, C Denkert, A Di Leo, B Ejlertsen, P Francis, V Galimberti, J Garber, B Gulluoglu, P Goodwin, N Harbeck, D F Hayes, C-S Huang, J Huober, K Hussein, J Jassem, Z Jiang, P Karlsson, M Morrow, R Orecchia, K C Osborne, O Pagani, A H Partridge, K Pritchard, J Ro, E J T Rutgers, F Sedlmayer, V Semiglazov, Z Shao, I Smith, M Toi, A Tutt, G Viale, T Watanabe, T J Whelan, B Xu
The 15th St. Gallen International Breast Cancer Conference 2017 in Vienna, Austria reviewed substantial new evidence on loco-regional and systemic therapies for early breast cancer. Treatments were assessed in light of their intensity, duration and side-effects, seeking where appropriate to escalate or de-escalate therapies based on likely benefits as predicted by tumor stage and tumor biology. The Panel favored several interventions that may reduce surgical morbidity, including acceptance of 2 mm margins for DCIS, the resection of residual cancer (but not baseline extent of cancer) in women undergoing neoadjuvant therapy, acceptance of sentinel node biopsy following neoadjuvant treatment of many patients, and the preference for neoadjuvant therapy in HER2 positive and triple-negative, stage II and III breast cancer...
August 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28836279/open-flap-debridement-of-peri-implantitis-with-or-without-adjunctive-systemic-antibiotics-a-randomized-clinical-trial
#16
Hadar Hallström, G Rutger Persson, Susann Lindgren, Stefan Renvert
AIMS: To investigate clinical, radiographic and microbiological outcome over 12 months following open flap debridement of peri-implantitis with or without antibiotics. MATERIALS AND METHODS: Peri-implantitis was surgically treated with or without Zithromax(®) in 19 control and 20 test individuals. Probing pocket depth (PPD), gingival inflammation (BOP), intra-oral radiographs and microbial samples were studied. Per protocol, and intent to treat analyzes were performed...
August 23, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28834758/alloimmune-responses-of-humanized-mice-to-human-pluripotent-stem-cell-therapeutics
#17
Nigel G Kooreman, Patricia E de Almeida, Jonathan P Stack, Raman V Nelakanti, Sebastian Diecke, Ning-Yi Shao, Rutger-Jan Swijnenburg, Veronica Sanchez-Freire, Elena Matsa, Chun Liu, Andrew J Connolly, Jaap F Hamming, Paul H A Quax, Michael A Brehm, Dale L Greiner, Leonard D Shultz, Joseph C Wu
There is growing interest in using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) derivatives for tissue regeneration. However, an increased understanding of human immune responses to stem cell-derived allografts is necessary for maintaining long-term graft persistence. To model this alloimmunity, humanized mice engrafted with human hematopoietic and immune cells could prove to be useful. In this study, an in-depth analysis of graft-infiltrating human lymphocytes and splenocytes revealed that humanized mice incompletely model human immune responses toward allogeneic stem cells and their derivatives...
August 22, 2017: Cell Reports
https://www.readbyqxmd.com/read/28823026/oxygenated-deep-bottoms-beneath-a-thick-hypoxic-layer-lack-potential-of-benthic-colonization
#18
Anders Stigebrandt, Rutger Rosenberg, Marina Magnusson, Torsten Linders
No abstract text is available yet for this article.
August 19, 2017: Ambio
https://www.readbyqxmd.com/read/28818521/current-approach-of-the-axilla-in-patients-with-early-stage-breast-cancer
#19
REVIEW
Eleftherios P Mamounas, Thorsten Kuehn, Emiel J T Rutgers, Gunter von Minckwitz
The surgical approach of the axilla in patients with early-stage breast cancer has witnessed considerable evolution during the past 25 years. The previously undisputed gold standard of axillary-lymph-node dissection for staging has now been replaced by sentinel-lymph-node biopsy for patients with clinically negative axilla. For selected patients with limited sentinel-lymph-node involvement, completion axillary-lymph-node dissection can be omitted or replaced by axillary radiotherapy, reducing morbidity. The clinical interest of axillary staging after neoadjuvant chemotherapy is increasing and this approach might contribute to morbidity reduction, and to the further tailoring of future systemic and locoregional treatment decisions by response assessment...
August 14, 2017: Lancet
https://www.readbyqxmd.com/read/28815012/the-2016-ming-k-jeang-award-for-excellence-in-cell-bioscience
#20
EDITORIAL
Yun-Bo Shi
Two research groups led by Dr. Jim Hu of University of Toronto, Canada and Dr. Renping Zhou of Rutgers University, USA, respectively, won the 2016 Ming K Jeang Award for Excellence in Cell & Bioscience.
2017: Cell & Bioscience
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