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https://www.readbyqxmd.com/read/29778504/solitary-chemosensory-cells-are-a-primary-epithelial-source-of-interleukin-25-in-chronic-rhinosinusitis-with-nasal-polyps
#1
Michael A Kohanski, Alan D Workman, Neil N Patel, Li-Yin Hung, Julie P Shtraks, Bei Chen, Mariel Blasetti, Laurel Doghramji, David W Kennedy, Nithin D Adappa, James N Palmer, De'Broski R Herbert, Noam A Cohen
BACKGROUND: IL-25 can function as an early signal for the respiratory Type 2 response characteristic of allergic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). In the mouse gut, tuft cells are the epithelial source of IL-25. However, the source of human airway epithelial IL-25 has remained elusive. OBJECTIVE: In this study, we sought to determine if the solitary chemosensory cell (SCC) is the predominant source of IL-25 in the sinonasal epithelium...
May 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29775025/-study-on-the-mutation-of-filaggrin-gene-in-nasal-polyps
#2
Q Zhou, W L Bai, J X Li
Objective: The aim of this study is to investigate the relationship between Filaggrin ( FLG ) gene mutations and nasal polyps. Method: Genomic DNA was extract from 48 nasal polyps tissues, and 30 samples of inferior turbinate tissues from normal human controls. Two FLG gene mutation points (R501X and 3321delA) were detected by polymerase chain reaction (PCR) first, then detected by polypropylene gel electrophoresis, and finally gene sequencing. Result: The FLG gene c. 3321delA was found in 2 cases (4.17%) of nasal polyps, both of them were heterozygous mutations...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775004/-detection-of-differentially-expressed-gene-of-allergic-rhinitis-based-on-rt%C3%A2-profiler-pcr-array
#3
Y Peng, X Q Li, Q H Qiu
Objective: The aim of this study is to detect differentially expressed gene of allergic rhinitis (AR) based on RT² profiler PCR array. Method: The real-time PCR array containing 84 genes were used to compare inferior turbinate samples obtained from AR patients (n=8) and healthy individuals (n=8). Result: The results showed that 67 genes were down regulated and 17 genes were up regulated in AR inferior turbinate after analysis of 84 genes related to allergy and asthma. STAT6 and BCL6 were recognized as differentially expressed genes...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29771036/-3d-computed-tomographic-study-of-concha-bullosa-drainage-pathway
#4
W H Zhang, Y L Zhao, X D Li
Objective: The aim of this study is to study the related structures with concha bullosa drainage passway in inpatients with concha bullosa disease. Method: A total of 90 patients with peritubular middle turbinate (144 sides) were examined by 16-slice spiral CT. The distribution of the middle turbinate and the distribution of the drainage channel were analyzed by three-dimensional reconstruction technique and image workstation software. Result: The distribution of the morphology and drainage channel of 144 concha bullosa have statistically significant ( P <0...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29768421/theoretical-analysis-and-design-of-hydro-hammer-with-a-jet-actuator-an-engineering-application-to-improve-the-penetration-rate-of-directional-well-drilling-in-hard-rock-formations
#5
Jiang-Fu He, Yun-Pei Liang, Li-Jia Li, Yong-Jiang Luo
Rapid horizontal directional well drilling in hard or fractured formations requires efficient drilling technology. The penetration rate of conventional hard rock drilling technology in horizontal directional well excavations is relatively low, resulting in multiple overgrinding of drill cuttings in bottom boreholes. Conventional drilling techniques with reamer or diamond drill bit face difficulties due to the long construction periods, low penetration rates, and high engineering costs in the directional well drilling of hard rock...
2018: PloS One
https://www.readbyqxmd.com/read/29768034/staphylococcus-aureus-induces-mucosal-type-2-immune-response-via-epithelial-cell-derived-cytokines
#6
Feng Lan, Nan Zhang, Gabriele Holtappels, Natalie De Ruyck, Olga Krysko, Koen Van Crombruggen, Harald Braun, Sebastian L Johnston, Nikos G Papadopoulos, Luo Zhang, Claus Bachert
RATIONALE: Chronic rhinosinusitis with nasal polyps is characterized by a T helper cell 2-skewed upper airway inflammation. Mucosal Staphylococcus aureus colonization is found in the majority of nasal polyps patients. Staphylococcus aureus is known to induce type 2 cytokine release via enterotoxins. OBJECTIVES: We investigated the impact of non-enterotoxin producing Staphylococcus aureus on type 2 cytokine release. METHODS: Thymic stromal lymphopoietin, interleukin-33 and type 2 cytokines were assessed in a human mucosal tissue model upon Staphylococcus aureus infection...
May 16, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29764849/10-year-old-with-concha-bullosa-pyogenic-mucocele
#7
Milos Fuglsang, Leif Hovgaard Sørensen, Kristian Bruun Petersen, Jesper Bille
A 10-year-old girl presented with episodes of migraine. A nasal mass was found randomly during work-up. Interpreted as an osteoma, the mass was removed during endoscopic surgery. However, the histopathological examination turned out to be a pyomucocele in the right middle turbinate, which is an extremely rare yet benign condition in children.
May 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29764740/are-computed-tomography-3d-measurements-of-the-upper-airways-in-mouth-breathing-children-in-agreement-with-the-ent-clinical-diagnosis-of-obstruction
#8
Bruno César Ladeira Vidigal, Carolina Morsani Mordente, Paula Loureiro Cheib, Flávio Ricardo Manzi, Letícia Paiva Franco, Helena Maria Gonçalves Becker, Bernardo Quiroga Souki
INTRODUCTION: Imaging studies have hystorically been used to support the clinical otorhinolaryngological evaluation of the upper respiratory tract for the diagnosis of obstructive causes of oral breathing. OBJECTIVE: The objective of this study was to compare 3D volumetric measurements of nasal cavity, nasopharynx and oropharynx of obstructed mouth-breathing children with measurements of non-obstructed mouth-breathing children. METHODS: This retrospective study included 25 mouth-breathing children aged 5-9 years evaluated by otorhinolaryngological clinical examination, flexible nasoendoscopy and full-head multi-slice computed tomography...
March 11, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29764011/efficacy-and-safety-of-autologous-stromal-vascular-fraction-in-the-treatment-of-empty-nose-syndrome
#9
Do-Youn Kim, Hye Ran Hong, Eun Wook Choi, Sang Won Yoon, Yong Ju Jang
Objectives: Regenerative treatment using stem cells may serve as treatment option for empty nose syndrome (ENS), which is caused by the lack of turbinate tissue and deranged nervous system in the nasal cavity. We aimed to assess the efficacy and safety of the autologous stromal vascular fraction (SVF) in the treatment of ENS. Methods: In this prospective observational clinical study, we enrolled 10 ENS patients who volunteered to undergo treatment of ENS through the injection of autologous SVF...
May 16, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29762505/features-of-cross-correlation-analysis-in-a-data-driven-approach-for-structural-damage-assessment
#10
Jhonatan Camacho Navarro, Magda Ruiz, Rodolfo Villamizar, Luis Mujica, Jabid Quiroga
This work discusses the advantage of using cross-correlation analysis in a data-driven approach based on principal component analysis (PCA) and piezodiagnostics to obtain successful diagnosis of events in structural health monitoring (SHM). In this sense, the identification of noisy data and outliers, as well as the management of data cleansing stages can be facilitated through the implementation of a preprocessing stage based on cross-correlation functions. Additionally, this work evidences an improvement in damage detection when the cross-correlation is included as part of the whole damage assessment approach...
May 15, 2018: Sensors
https://www.readbyqxmd.com/read/29759597/performance-and-robustness-of-optimal-fractional-fuzzy-pid-controllers-for-pitch-control-of-a-wind-turbine-using-chaotic-optimization-algorithms
#11
Amirhossein Asgharnia, Reza Shahnazi, Ali Jamali
The most studied controller for pitch control of wind turbines is proportional-integral-derivative (PID) controller. However, due to uncertainties in wind turbine modeling and wind speed profiles, the need for more effective controllers is inevitable. On the other hand, the parameters of PID controller usually are unknown and should be selected by the designer which is neither a straightforward task nor optimal. To cope with these drawbacks, in this paper, two advanced controllers called fuzzy PID (FPID) and fractional-order fuzzy PID (FOFPID) are proposed to improve the pitch control performance...
May 11, 2018: ISA Transactions
https://www.readbyqxmd.com/read/29757617/freeze-casting-produces-a-graphene-oxide-aerogel-with-a-radial-and-centrosymmetric-structure
#12
Chunhui Wang, Xiong Chen, Bin Wang, Ming Huang, Bo Wang, Yi Jiang, Rodney S Ruoff
We report the assembly of graphene oxide (G-O) building blocks into a vertical and radially aligned structure by a bidirectional freeze-casting approach. The crystallization of water to ice assembles the G-O sheets into a structure, a G-O aerogel whose local structure mimics turbine blades. The centimeter-scale radiating structure in this aerogel has many channels whose width increases with distance from the center. This was achieved by controlling the formation of the ice crystals in the aqueous G-O dispersion that grew radially in the shape of lamellae during freezing...
May 14, 2018: ACS Nano
https://www.readbyqxmd.com/read/29756610/the-hump-columellar-strut-a-reliable-technique-for-correction-of-nasal-tip-underprojection
#13
P G Giacomini, S Mocella, S DI Girolamo, R DE Berardinis, A Boccieri
Nasal tip under projection is often found in rhinoplasty cases both for congenital or post-traumatic deformity. Nasal trauma may result in alteration of the external and internal nasal structures with following aesthetic impairment and difficulties in breathing. Post-traumatic surgery is frequent, but restoration of pre-traumatic form and function remains a challenge. The present paper describes a new method to increase tip projection by a columellar strut harvested from the autologous nasal bone and cartilage of the resected hump...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29756518/the-route-by-which-intranasally-delivered-stem-cells-enter-the-central-nervous-system
#14
Carlos Galeano, Zhifang Qiu, Anuja Mishra, Steven L Farnsworth, Jacob J Hemmi, Alvaro Moreira, Peter Edenhoffer, Peter J Hornsby
Intranasal administration is a promising route of delivery of stem cells to the central nervous system (CNS). Reports on this mode of stem cell delivery have not yet focused on the route across the cribriform plate by which cells move from the nasal cavity into the CNS. In the current experiments, human mesenchymal stem cells (MSCs) were isolated from Wharton's jelly of umbilical cords and were labeled with extremely bright quantum dots (QDs) in order to track the cells efficiently. At 2 h after intranasal delivery in immunodeficient mice, the labeled cells were found under the olfactory epithelium, crossing the cribriform plate adjacent to the fila olfactoria, and associated with the meninges of the olfactory bulb...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29756407/a-prospective-study-for-treatment-of-nasal-valve-collapse-due-to-lateral-wall-insufficiency-outcomes-using-a-bioabsorbable-implant
#15
Pablo Stolovitzky, Douglas M Sidle, Randall A Ow, Nathan E Nachlas, Sam P Most
OBJECTIVE: To examine 6-month outcomes for treatment of lateral nasal wall insufficiency with a bioabsorbable implant. STUDY DESIGN: Prospective, multicenter, nonrandomized, single-blinded study. METHODS: One hundred and one patients with severe-to-extreme class of Nasal Obstruction Symptom Evaluation (NOSE) scores were enrolled at 14 U.S. clinics (September 2016-March 2017). Patients were treated with a bioabsorbable implant designed to support lateral wall, with or without concurrent septoplasty and/or turbinate reduction procedure(s)...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29756404/nasal-fibroscopy-as-a-routine-screening-procedure-of-sinonasal-adenocarcinoma-of-woodworkers-french-longitudinal-case-study
#16
Julie Martin, Flora Vayr, Christophe Paris, Sébastien Vergez, Peggy Krief, Amandine Luc, Julie Corvisier, Ludovic de Gabory, Fabrice Herin
BACKGROUND: The purpose of this study was to assess the relevancy of flexible nasoendoscopy as a routine screening procedure of sinonasal adenocarcinoma among people occupationally exposed to wood dust. METHODS: This study included woodworkers, occupationally exposed to wood dust. Evaluations were scheduled at the time of inclusion (T0) and after a 2-year period (T1). A questionnaire was used for standardized data collection. The score was based on anatomic landmarks on each side that are parts of the olfactory clefts: the area of middle turbinate, the anterior part of the olfactory cleft, the top of the choanal arch, the spheno-ethmoidal recess, the posterior part of the olfactory cleft, and the middle part of the olfactory cleft...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29753509/the-first-integrated-aortic-turbine-venous-assist-system-is-born
#17
EDITORIAL
Lok Sinha, Can Yerebakan
No abstract text is available yet for this article.
April 12, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29750587/the-microbiologic-profile-of-dacryocystitis
#18
Stella Y Chung, Leon Rafailov, Roger E Turbin, Paul D Langer
PURPOSE: Recent studies suggest an increasing incidence of gram-negative bacteria and methicillin-resistant Staphylococcus aureus in dacryocystitis. Since patients are often treated empirically without culture data, a changing microbiologic profile will markedly affect the success of oral treatment. To provide current guidelines for the treatment of this common condition, we investigated the microbiology and antibiogram of dacryocystitis seen at our institution. METHODS: The charts of all patients presenting with acute and/or chronic dacryocystitis in University Hospital, Newark, from 2007 to 2015 were reviewed...
May 11, 2018: Orbit
https://www.readbyqxmd.com/read/29749920/evolution-of-the-graded-repair-of-csf-leaks-and-skull-base-defects-in-endonasal-endoscopic-tumor-surgery-trends-in-repair-failure-and-meningitis-rates-in-509-patients
#19
Andrew Conger, Fan Zhao, Xiaowen Wang, Amalia Eisenberg, Chester Griffiths, Felice Esposito, Ricardo L Carrau, Garni Barkhoudarian, Daniel F Kelly
OBJECTIVE The authors previously described a graded approach to skull base repair following endonasal microscopic or endoscope-assisted tumor surgery. In this paper they review their experience with skull base reconstruction in the endoscopic era. METHODS A retrospective review of a single-institution endonasal endoscopic patient database (April 2010-April 2017) was undertaken. Intraoperative CSF leaks were graded based on size (grade 0 [no leak], 1, 2, or 3), and repair technique was documented across grades...
May 11, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29743254/evolutionary-adaptation-to-aquatic-lifestyle-in-extinct-sloths-can-lead-to-systemic-alteration-of-bone-structure
#20
Eli Amson, Guillaume Billet, Christian de Muizon
Through phenotypic plasticity, bones can change in structure and morphology, in response to physiological and biomechanical influences over the course of individual life. Changes in bones also occur in evolution as functional adaptations to the environment. In this study, we report on the evolution of bone mass increase (BMI) that occurred in the postcranium and skull of extinct aquatic sloths. Although non-pathological BMI in postcranial skeleton has been known in aquatic mammals, we here document general BMI in the skull for the first time...
May 16, 2018: Proceedings. Biological Sciences
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