Ruo-Bing Guo, Yin-Feng Dong, Zhi Yin, Zhen-Yu Cai, Jin Yang, Juan Ji, Yu-Qin Sun, Xin-Xin Huang, Teng-Fei Xue, Hong Cheng, Xi-Qiao Zhou, Xiu-Lan Sun
Pericytes are present tight around the intervals of capillaries, play an essential role in stabilizing the blood-brain barrier, regulating blood flow and immunomodulation, and persistent contraction of pericytes eventually leads to impaired blood flow and poor clinical outcomes in ischemic stroke. We previously show that iptakalim, an ATP-sensitive potassium (K-ATP) channel opener, exerts protective effects in neurons, and glia against ischemia-induced injury. In this study we investigated the impacts of iptakalim on pericytes contraction in stroke...
June 2022: Acta Pharmacologica Sinica