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hogdkin lymphoma

A Rotte, J Y Jin, V Lemaire
Checkpoint receptor blockers, known to act by blocking the pathways that inhibit immune cell activation and stimulate immune responses against tumor cells, have been immensely successful in the treatment of cancer. Among several checkpoint receptors of immune cells, cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), programmed cell death protein-1 (PD-1), T-cell immunoglobulin and ITIM domain (TIGIT), T-cell immunoglobulin-3 (TIM-3) and lymphocyte activation gene 3 (LAG-3) are the most commonly targeted checkpoints for cancer immunotherapy...
January 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
V R Lopez Gamboa, M J Blanzari, A Sardoy, A Campana, M J Nocito, A Bringas, A Gómez, S Zanni, S Maldonado, A Guidi, B M Papa
Paraneoplastic dermatomyositis is an inflammatory disease of the connective tissue that is caused by inmmunologic events in the presence of malignant tumors. It is more likely to happen in middle aged women and is related to ovarian, pancreatic, stomach and colon cancer and non Hogdkin lymphoma. We present two cases of dermatomyositis, with amyopathic origin associated to breast cancer. The first case occurs as the neoplasia evolves and the second one as an initial manifestation that leads to the search and subsequent diagnosis of cancer...
2015: Revista de la Facultad de Ciencias Médicas
Koramadai Karuppusamy Kamaleshwaran, Thirugnanam Rajasekar, Deepu Shibu, Edathurthy Kalarikal Radhakrishnan, Ajit Sugunan Shinto
Post-transplant lymphoproliferative disorder (PTLD) is a heterogeneous group of lymphoid proliferations caused by immunosuppression after solid organ or bone marrow transplantation. PTLD is categorized by early lesion, polymorphic PTLD and monomorphic PTLD. Fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography (F-18 FDG-PET/CT) scans have clinical significance in the evaluation of PTLD following renal transplantation. We report imaging findings of a monomorphic non-Hodgkin lymphoma, post renal transplant seen on FDG PET/CT in a 32-year-old lactating woman...
July 2014: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Vinit Suri, Nadeem I Khan, Nilesh Jadhao, Rohan Gupta
Paraneoplastic cerebellar degeneration (PCD) is a rare disorder presenting typically with acute or subacute severe cerebellar ataxia. PCD is most commonly associated with small cell lung cancer followed by adenocarcinoma of breast and ovary, and Hogdkin's lymphoma. We report a case of a 54-year-old male with acute-onset pancerebellar syndrome with underlying Hodgkin's lymphoma. A high index of suspicion of PCD resulted in arriving at an early diagnosis of underlying Hodgkin's disease. The patient was managed with six cycles of chemotherapy, which resulted in clinical stabilization and reversal of magnetic resonance imaging abnormalities...
July 2012: Annals of Indian Academy of Neurology
Tanawan Kummalue, Anchalee Chuphrom, Sanya Sukpanichanant, Tawatchai Pongpruttipan, Sathien Sukpanichanant
UNLABELLED: Malignant lymphoma, especially non-Hodgkin lymphoma, is one of the most common hematologic malignancies in Thailand. The diagnosis of malignant lymphoma is often problematic, especially in early stages of the disease. Detection of antigen receptor gene rearrangement including T cell receptor (TCR) and immunoglobulin heavy chain (IgH) by polymerase chain reaction followed by heteroduplex has currently become standard whereas fluorescent fragment analysis (GeneScan) has been used for confirmation test...
2010: Diagnostic Pathology
E P Spugnini, G Citro, P Mellone, I Dotsinsky, N Mudrov, A Baldi
Non Hogdkin's lymphoma is the commonest malignant neoplasm in humans and in pets. Treatments include systemic chemotherapy eventually combined with radiation therapy. Radiation therapy is also used as single agent for the treatment of localized lymphoma (LSA). Albeit efficacious, this modality is potentially associated with side effects. Purpose of this study was to preliminarily evaluate the feasibility and efficacy of electrochemotherapy (ECT) in companion animals with localized lymphoma. Six patients entered the study and received two sessions of ECT under sedation...
September 2007: Journal of Experimental & Clinical Cancer Research: CR
Andrew M Evens, Christiane Querfeld, Steven T Rosen
No abstract text is available yet for this article.
2006: Cancer Treatment and Research
Amando Peydró-Olaya, Antonio Llombart-Bosch, Carmen Carda-Batalla, Jose Antonio Lopez-Guerrero
The current study disusses a new approach to the group of small round cell tumors (SRCTs) independently of their primary anatomical location. We perform this analysis supported mainly by morphological means and particularly with the help of immunohistochemistry and electron microscopy; the last of which continues to play a decisive role in their differential diagnosis. The microscopical similarity of many of these tumors often makes the diagnosis in routine histology extremely difficult, due to the varying degree of heterogeneity present, and may have important therapeutic and prognostic implications...
February 2003: Seminars in Diagnostic Pathology
O J Stötzer, M Schleuning, G Ledderose, W Hiddemann, H J Kolb
INTRODUCTION: Allogeneic transplantation of bone marrow and peripheral blood stem cells is a frequently discussed therapeutic option in the treatment of malignant lymphoma. By analysing the results of our own transplant program in patients with advanced lymphoma we tried to evaluate indications for allogeneic transplantations. METHODS: Data from lymphoma patients treated at the Klinikum Grosshadern between 1985 and 2001 were analysed retrospectively. RESULTS: 56 patients were included...
September 28, 2001: Deutsche Medizinische Wochenschrift
T Powles, G Matthews, M Bower
OBJECTIVE: To review the current literature on HIV associated non-Hodgkin's lymphoma. METHODS: A comprehensive Medline/Pubmed search of articles pertaining to HIV associated non-Hodgkin's lymphoma as well as personal experience from the treatment of over 200 patients at the Chelsea and Westminster Hospital, one of the largest centres for the management of HIV disease in Europe. CONCLUSION: High grade B cell non-Hogdkin's lymphoma is the second commonest tumour affecting people with HIV...
October 2000: Sexually Transmitted Infections
R Rubio
BACKGROUND: Hogdkin's disease is not an acquired immunodeficiency syndrome (AIDS)-defining illness. However, Hodgkin's disease associated with human immunodeficiency virus (HIV) infection has a different natural history and therapeutic outcome than in the general population of Hodgkin's disease patients. METHODS: The authors studied the epidemiologic and clinicopathologic features and therapeutic outcomes of 46 patients with Hodgkin's disease associated with HIV infection collected from a cooperative study of nine hospitals in Madrid, Spain...
May 1, 1994: Cancer
S T Pals, C J Meijer, T Radaszkiewicz
Lymphocyte migration to lymphoid organs involves tissue-specific homing receptors. A lectin-like surface glycoprotein of 80 kD, the LECAM-1 (LAM-1, Leu-8) antigen, has recently been shown to represent the human equivalent of the mouse peripheral lymph node homing receptor MEL-14. In this study, the expression of LECAM-1 was examined in 116 nodal and 53 gastrointestinal (GI) non-Hogdkin's lymphomas (NHL). This analysis revealed that whereas the majority of nodal lymphomas expressed LECAM-1, this molecule was generally absent on GI lymphomas...
July 1991: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
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