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https://www.readbyqxmd.com/read/28636311/insights-into-integrated-lead-generation-and-target-identification-in-malaria-and-tuberculosis-drug-discovery
#1
John Okombo, Kelly Chibale
New, safe and effective drugs are urgently needed to treat and control malaria and tuberculosis, which affect millions of people annually. However, financial return on investment in the poor settings where these diseases are mostly prevalent is very minimal to support market-driven drug discovery and development. Moreover, the imminent loss of therapeutic lifespan of existing therapies due to evolution and spread of drug resistance further compounds the urgency to identify novel effective drugs. However, the advent of new public-private partnerships focused on tropical diseases and the recent release of large data sets by pharmaceutical companies on antimalarial and antituberculosis compounds derived from phenotypic whole cell high throughput screening have spurred renewed interest and opened new frontiers in malaria and tuberculosis drug discovery...
June 21, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28634488/antiherding-in-financial-decision-increases-valuation-of-return-on-investment-an-event-related-potential-study
#2
Cuicui Wang, Jia Jin, João Paulo Vieito, Qingguo Ma
Using event-related potentials, this study investigated how financial herding or antiherding affected the valuation of subsequent outcomes. For each trial, subjects decided whether to buy the stock according to its net money flow information which could be used to reflect the strength of buying power or selling power of the stock. The return on investment (ROI) as feedback included the increase or decrease percentage after subjects' responses. Results showed that, compared with herding, antiherding induced larger discrepancies of FRN and P300 amplitude between positive ROI and negative ROI, indicating that individuals under antiherding condition had stronger motivation and paid more attention in the evaluation process of ROI...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28629438/an-output-evaluation-of-a-health-research-foundation-s-enhanced-grant-review-process-for-new-investigators
#3
Gregory W Hammond, Mê-Linh Lê, Tannis Novotny, Stephanie P B Caligiuri, Grant N Pierce, John Wade
BACKGROUND: We assessed the ability of the Manitoba Medical Service Foundation (MMSF, a small not-for-profit foundation affiliated with Manitoba Blue Cross) to determine the best candidates for selection to receive research funding support among new researchers applying to the Research Operating Grants Programme (ROGP). METHODS: Using bibliometric and grants funding analyses, we retrospectively compared indices of academic outputs from five cohorts of MMSF-funded and not MMSF-funded applicants to the annual MMSF ROGP over 2008 to 2012, from 1 to 5 years after having received evaluation decisions from the MMSF enhanced grant review process...
June 19, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28617238/public-health-policy-in-support-of-insurance-coverage-for-smoking-cessation-treatments
#4
Robert Schwartz, Farzana Haji, Alexey Babayan, Christopher Longo, Roberta Ferrence
Insurance coverage for evidence-based smoking cessation treatments (SCTs) promotes uptake and reduces smoking rates. Published studies in this area are based in the US where employers are the primary source of health insurance. In Ontario, Canada, publicly funded healthcare does not cover SCTs, but it can be supplemented with employer-sponsored benefit plans. This study explores factors affecting the inclusion/exclusion of smoking cessation (SC) benefits. In total, 17 interviews were conducted with eight employers (auto, retail, banking, municipal and university industries), four health insurers, two government representatives and three advisors/consultants...
May 2017: Healthcare Policy, Politiques de Santé
https://www.readbyqxmd.com/read/28611876/effectiveness-of-resident-physicians-as-triage-liaison-providers-in-an-academic-emergency-department
#5
Victoria Weston, Sushil K Jain, Michael Gottlieb, Amer Aldeen, Stephanie Gravenor, Michael J Schmidt, Sanjeev Malik
INTRODUCTION: Emergency department (ED) crowding is associated with detrimental effects on ED quality of care. Triage liaison providers (TLP) have been used to mitigate the effects of crowding. Prior studies have evaluated attending physicians and advanced practice providers as TLPs, with limited data evaluating resident physicians as TLPs. This study compares operational performance outcomes between resident and attending physicians as TLPs. METHODS: This retrospective cohort study compared aggregate operational performance at an urban, academic ED during pre- and post-TLP periods...
June 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28611873/the-economics-of-an-admissions-holding-unit
#6
Kraftin E Schreyer, Richard Martin
INTRODUCTION: With increasing attention to the actual cost of delivering care, return-on-investment calculations take on new significance. Boarded patients in the emergency department (ED) are harmful to clinical care and have significant financial opportunity costs. We hypothesize that investment in an admissions holding unit for admitted ED patients not only captures opportunity cost but also significantly lowers direct cost of care. METHODS: This was a three-phase study at a busy urban teaching center with significant walkout rate...
June 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28611727/non-invasive-brain-stimulation-to-enhance-upper-limb-motor-practice-poststroke-a-model-for-selection-of-cortical-site
#7
Michelle L Harris-Love, Rachael M Harrington
Motor practice is an essential part of upper limb motor recovery following stroke. To be effective, it must be intensive with a high number of repetitions. Despite the time and effort required, gains made from practice alone are often relatively limited, and substantial residual impairment remains. Using non-invasive brain stimulation to modulate cortical excitability prior to practice could enhance the effects of practice and provide greater returns on the investment of time and effort. However, determining which cortical area to target is not trivial...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28605615/cancer-drugs-an-international-comparison-of-postlicensing-price-inflation
#8
Philip Savage, Sarah Mahmoud, Yogin Patel, Hagop Kantarjian
PURPOSE: The cost of cancer drugs forms a rising proportion of health care budgets worldwide. A number of studies have examined international comparisons of initial cost, but there is little work on postlicensing price increases. To examine this, we compared cancer drug prices at initial sale and subsequent price inflation in the United States and United Kingdom and also reviewed relevant price control mechanisms. METHODS: The 10 top-selling cancer drugs were selected, and their prices at initial launch and in 2015 were compared...
June 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28605436/innovation-in-cardiovascular-disease-in-europe-with-focus-on-arrhythmias-current-status-opportunities-roadblocks-and-the-role-of-multiple-stakeholders
#9
Frits W Prinzen, Nikolaos Dagres, Andreas Bollmann, David O Arnar, Sylvie Bove, John Camm, Barbara Casadei, Paulus Kirchhof, Karl-Heinz Kuck, Joost Lumens, Martin C Michel, Peter J Schwartz, Betty Van Vleymen, Panos Vardas, Gerhard Hindricks
The European Heart Rhythm Association (EHRA) held an Innovation Forum in February 2016, to consider issues around innovation. The objective of the forum was to extend the innovation debate outside of the narrow world of arrhythmia specialists and cardiology in general, and seek input from all stakeholders including regulators, strategists, technologists, industry, academia, health providers, medical societies, payers, and patients. Innovation is indispensable for a continuing improvement in health care, preferably at higher efficacy and lower costs...
June 12, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28596742/assessing-the-growth-of-ethical-banking-some-evidence-from-spanish-customers
#10
Fernando E Callejas-Albiñana, Isabel Martínez-Rodríguez, Ana I Callejas-Albiñana, Irene M de Vidales-Carrasco
Aristotle, who, having predated Adam Smith by 2000 years, deserves to be recognized as the world's first economist (Solomon, 1995), distinguished between two different senses of what we call economics: oikonomikos, or household trading, which he approved of and considered essential to the working of any even slightly complex society, and chrematisike, or trade for profit, which he considered selfish and utterly devoid of virtue, calling those who engaged in such practices "parasites". Of course, consumers do not purchase and invest for solely economic reasons (Polanyi, 1944)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28593037/targeted-approaches-to-improve-outcomes-for-highest-cost-patients
#11
EDITORIAL
Adam J Rose
Bash and colleagues, using data from Maccabi Healthcare Services, have documented increased cost and utilization attributable to patients with congestive heart failure (CHF). The CHF patients were older than the general population and had high rates of important comorbid conditions. While it is somewhat predictable that such a population would have higher healthcare utilization and costs, the extent of the difference was still surprising. Most CHF patients (78%) were hospitalized at least once, compared to only 21% of patients without CHF...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28589521/strengthening-the-case-for-epilepsy-drug-development-bridging-experiences-from-the-alzheimer-s-disease-field-an-opinion
#12
Roy E Twyman
Given the sheer number of drugs (over 20!) available for treatment of seizures, epilepsy can be considered one of the most successful areas in pharmaceutical development and especially for neuroscience. However, despite the large number of drug treatment options available for managing patients with epilepsy, there remains considerable unmet need. For example, the overall impact on seizure control has not been substantial with approximately 30% of patients remaining refractory or their seizures not adequately controlled...
June 7, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28588988/how-prevention-of-violence-in-childhood-builds-healthier-economies-and-smarter-children-in-the-asia-and-pacific-region
#13
Deborah Fry, Stephen Blight
Investments in preventing violence against children in the Asia and Pacific region will bring important social and economic returns that contribute to building the region's 'cognitive capital'. An analysis of burden of violence research in the region is presented to identify the impacts of violence and to demonstrate these returns. Violence is an everyday experience in the lives of many children in the Asia-Pacific, and the toxic stress associated with such routine forms of violence may permanently impact the architecture and chemistry of the developing brain...
November 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28586789/the-effect-of-positive-swog-treatment-trials-on-survival-of-patients-with-cancer-in-the-us-population
#14
Joseph M Unger, Michael LeBlanc, Charles D Blanke
Importance: Recently, tremendous prominence has been given to the investigation of the effect of different research processes as part of the Cancer Moonshot. More than half a century ago, the National Cancer Institute (NCI) established a network of publicly funded cancer cooperative research groups to systematically evaluate new treatments for efficacy and safety. Objective: To examine the extent to which positive NCI-sponsored cancer treatment trials have benefited patients with cancer in the US population...
June 5, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28576507/dementia-registries-around-the-globe-and-their-applications-a-systematic-review
#15
REVIEW
Karolina Krysinska, Perminder S Sachdev, John Breitner, Miia Kivipelto, Walter Kukull, Henry Brodaty
Patient registries are valuable tools helping to address significant challenges in research, care, and policy. Registries, well embedded in many fields of medicine and public health, are relatively new in dementia. This systematic review presents the current situation in regards to dementia registries worldwide. We identified 31 dementia registries operating on an international, national, or local level between 1986 and 2016. More than half of the registries aimed to conduct or facilitate research, including preclinical research registries and registries recruiting research volunteers...
May 30, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28576295/alternative-payment-models-lead-to-strategic-care-coordination-workforce-investments
#16
Clese E Erikson, Patricia Pittman, Alicia LaFrance, Susan A Chapman
BACKGROUND: Care coordination is generally viewed as a key to success for health systems seeking to adapt to a range of new value-based payment policies. PURPOSE: This study explores care coordination staffing in four health systems participating in new payment models, including Medicaid payment reform and Accountable Care Organizations. METHODS: Comparative case study design is used to describe models of care coordination. Analysis of 43 semi-structured interviews with leadership, clinicians, and care coordination staff at four health systems engaged in value-based contracts...
April 13, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28574531/do-hcahps-doctor-communication-scores-reflect-the-communication-skills-of-the-attending-on-record-a-cautionary-tale-from-a-tertiary-care-medical-service
#17
Vicente J Velez, Roop Kaw, Bo Hu, Richard M Frankel, Amy K Windover, Dan Bokar, Julie M Rish, Michael B Rothberg
BACKGROUND: Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) scores measure patient satisfaction with hospital care. It is not known if these reflect the communication skills of the attending physician on record. The Four Habits Coding Scheme (4HCS) is a validated instrument that measures bedside physician communication skills according to 4 habits, namely: investing in the beginning, eliciting the patient's perspective, demonstrating empathy, and investing in the end...
June 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28570660/epidemiological-and-economic-impact-of-pandemic-influenza-in-chicago-priorities-for-vaccine-interventions
#18
Nargesalsadat Dorratoltaj, Achla Marathe, Bryan L Lewis, Samarth Swarup, Stephen G Eubank, Kaja M Abbas
The study objective is to estimate the epidemiological and economic impact of vaccine interventions during influenza pandemics in Chicago, and assist in vaccine intervention priorities. Scenarios of delay in vaccine introduction with limited vaccine efficacy and limited supplies are not unlikely in future influenza pandemics, as in the 2009 H1N1 influenza pandemic. We simulated influenza pandemics in Chicago using agent-based transmission dynamic modeling. Population was distributed among high-risk and non-high risk among 0-19, 20-64 and 65+ years subpopulations...
June 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28570356/commentary-on-evidence-based-self-management-programs-for-seniors-and-other-with-chronic-diseases-patient-experience-patient-health-return-on-investment
#19
Kate Lorig
No abstract text is available yet for this article.
July 2017: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/28566019/using-evidence-to-inform-practice-and-policy-to-enhance-the-quality-of-care-for-persons-with-traumatic-spinal-cord-injury
#20
Michael G Fehlings, Christiana L Cheng, Elaine Chan, Nancy P Thorogood, Vanessa K Noonan, Henry Ahn, Christopher Bailey, Anoushka Singh, Marcel F Dvorak
In today's economic climate there is a need to demonstrate a return on investment for healthcare spending and for clinical practice and policy to be informed by evidence. Navigating this process is difficult for decision-makers, clinicians and researchers alike. This article will describe how a knowledge translation framework and an evidence-based policy-making process were integrated to clarify the problem, frame options, and plan implementation, to impact clinical practice and policy in the area of traumatic spinal cord injury (tSCI)...
May 31, 2017: Journal of Neurotrauma
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