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myelodisplasic syndrome

F Guilloton, A de Thonel, C Jean, C Demur, V Mansat-De Mas, G Laurent, A Quillet-Mary
The mechanism by which leukemic cells interfere with normal hematopoiesis remains unclear. We show here that, whereas the leukemic KG1a cells are naturally devoid from cellular cytotoxicity, once activated by TNFalpha, they display cytolytic activity toward various cellular targets including CFU-GM. This mechanism is dependent on stimulation of the granzyme B/perforin system. In addition, KG1a cells expressed the NKG2D receptor and its signal-transducing adaptator DAP 10, which were functional as confirmed by redirected lysis experiments...
December 2005: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
G Dewulf, I Gouin, E Pautas, P Gaussem, P Chaïbi, J-P Andreux, V Siguret
Myelodysplastic syndrome (MDS) is particularly common in geriatric practice. As few data are available in very elderly patients, we conducted a 54-month retrospective study in patients over 70 years with MDS diagnosed at Hôpital Charles Foix. Patients with cobalamine, folate or iron deficiency were excluded. Regarding biological and morphologic approaches, MDS patients were classified according to the FAB criteria. We then tempted to reclassify the patients according to the WHO criteria. The Bournemouth scoring system was used as a prognostic tool...
March 2004: Annales de Biologie Clinique
P Giraldo Castellano, E Franco García, M Bernal Pérez, J Huelin Domeco de Jarauta, D Rubio-Félix, M Giralt Raichs
BACKGROUND: Aging probably comprises one of the major factors contributing to the onset of acquired primary blood diseases (APBD's) most of which are of a chronic type. The purpose of this study is to analyze the rate of occurrence (RO) of HPA in a population of 522,621 inhabitants (Males: 252,721; Females: 269,900) showing a negative vegetative growth (-1.4/10(5) inhabitants/year), said occurrence being dealt with separately for the population under age 60 and the population over age 60...
November 1998: Revista Española de Salud Pública
M C Guisasola Zulueta, A García de la Fuente, E Dulín Iñíguez, C Gilsanz Fernández
Myelodisplasic syndromes (MS) is a group of hematological alterations with well-known clinical, diagnosis, prognosis and therapeutic features. The etiology is still, however, unclear. Following the hypothesis of the lesion of the pluripotential cell, we have studied the composition of red cell membrane in 5 patients afflicted with MS (1 with refractory anemia; 3 refractory anemia plus excessive blast count and 1 chronic myelomonocytic leukemia). The red cells of the patients afflicted with MS has morphological alterations at examination in fresh...
February 1991: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
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