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Voxel based morphometry MRI

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https://www.readbyqxmd.com/read/28529875/advanced-magnetic-resonance-imaging-and-neuropsychological-assessment-for-detecting-brain-injury-in-a-prospective-cohort-of-university-amateur-boxers
#1
M G Hart, C R Housden, J Suckling, R Tait, A Young, U Müller, V F J Newcombe, I Jalloh, B Pearson, J Cross, R A Trivedi, J D Pickard, B J Sahakian, P J Hutchinson
BACKGROUND/AIM: The safety of amateur and professional boxing is a contentious issue. We hypothesised that advanced magnetic resonance imaging and neuropsychological testing could provide evidence of acute and early brain injury in amateur boxers. METHODS: We recruited 30 participants from a university amateur boxing club in a prospective cohort study. Magnetic resonance imaging (MRI) and neuropsychological testing was performed at three time points: prior to starting training; within 48 h following a first major competition to detect acute brain injury; and one year follow-up...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28503142/brain-gray-matter-atrophy-after-spinal-cord-injury-a-voxel-based-morphometry-study
#2
Qian Chen, Weimin Zheng, Xin Chen, Lu Wan, Wen Qin, Zhigang Qi, Nan Chen, Kuncheng Li
The aim of this study was to explore possible changes in whole brain gray matter volume (GMV) after spinal cord injury (SCI) using voxel-based morphometry (VBM), and to study their associations with the injury duration, severity, and clinical variables. In total, 21 patients with SCI (10 with complete and 11 with incomplete SCI) and 21 age- and sex-matched healthy controls (HCs) were recruited. The 3D high-resolution T1-weighted structural images of all subjects were obtained using a 3.0 Tesla MRI system. Disease duration and American Spinal Injury Association (ASIA) Scale scores were also obtained from each patient...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28501822/structural-mri-correlates-of-amyotrophic-lateral-sclerosis-progression
#3
Joe Senda, Naoki Atsuta, Hirohisa Watanabe, Epifanio Bagarinao, Kazunori Imai, Daichi Yokoi, Yuichi Riku, Michihito Masuda, Ryoichi Nakamura, Hazuki Watanabe, Mizuki Ito, Masahisa Katsuno, Shinji Naganawa, Gen Sobue
PURPOSE: Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical course and progression of ALS varies widely. Brain degeneration detected using structural MRI could reflect disease progression. SUBJECTS AND METHODS: On study registration, 3-Tesla volumetric MRI and diffusion tensor imaging scans were obtained at baseline in 38 healthy controls and 67 patients with sporadic ALS...
May 13, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28498515/brain-structure-linking-delay-discounting-and-academic-performance
#4
Song Wang, Feng Kong, Ming Zhou, Taolin Chen, Xun Yang, Guangxiang Chen, Qiyong Gong
As a component of self-discipline, delay discounting refers to the ability to wait longer for preferred rewards and plays a pivotal role in shaping students' academic performance. However, the neural basis of the association between delay discounting and academic performance remains largely unknown. Here, we examined the neuroanatomical substrates underlying delay discounting and academic performance in 214 adolescents via voxel-based morphometry (VBM) by performing structural magnetic resonance imaging (S-MRI)...
May 12, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28487114/structural-brain-network-analysis-of-children-with-localization-related-epilepsy
#5
Kanako Takeda, Hiroshi Matsuda, Yusaku Miyamoto, Hitoshi Yamamoto
INTRODUCTION: Epilepsy is considered to arise from dysfunction in neural networks. Recent advances in neuroimaging and its analysis have made it possible to investigate both functional and structural connectivity in the brain. The aim of this study was to elucidate alterations in the structural connectivity in children with localization-related epilepsy using the mathematical method of graph theoretical analysis. METHODOLOGY: Fifteen children with localization-related epilepsy (8 female subjects; mean age, 8...
May 6, 2017: Brain & Development
https://www.readbyqxmd.com/read/28481904/cortical-brain-volume-abnormalities-associated-with-few-or-multiple-neuropsychiatric-symptoms-in-alzheimer-s-disease
#6
Lyssandra Dos Santos Tascone, Martha E Payne, James MacFall, Dionísio Azevedo, Claudio Campi de Castro, David C Steffens, Geraldo F Busatto, Cássio M C Bottino
New research on assessing neuropsychiatric manifestations of Alzheimer´s Disease (AD) involves grouping neuropsychiatric symptoms into syndromes. Yet this approach is limited by high inter-subject variability in neuropsychiatric symptoms and a relatively low degree of concordance across studies attempting to cluster neuropsychiatric symptoms into syndromes. An alternative strategy that involves dichotomizing AD subjects into those with few versus multiple neuropsychiatric symptoms is both consonant with real-world clinical practice and can contribute to understanding neurobiological underpinnings of neuropsychiatric symptoms in AD patients...
2017: PloS One
https://www.readbyqxmd.com/read/28479531/-structural-brain-development-in-healthy-children-and-adolescents
#7
Izumi Matsudaira, Ryuta Kawashima, Yasuyuki Taki
Brain maturation progresses throughout childhood into adolescence. Investigating the mechanism of brain development during these periods in healthy people is necessary for some clinical purposes. For example, these mechanisms are needed to investigate the mechanism of impaired brain maturation in neurodevelopmental disorders-such as autism spectrum disorders or attention-deficit hyper disorder-and improve early prevention of psychiatric or neurodegenerative diseases like depression or Alzheimer's disease. Voxel-based morphometry (VBM) is an effective way to analyze brain magnetic resonance images (MRI) of children and adolescents, as the brain structures of children and adolescents vary widely depending on their age, sex, and several other factors...
May 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28473626/patterns-of-atrophy-in-pathologically-confirmed-dementias-a-voxelwise-analysis
#8
Lorna Harper, Femke Bouwman, Emma J Burton, Frederik Barkhof, Philip Scheltens, John T O'Brien, Nick C Fox, Gerard R Ridgway, Jonathan M Schott
OBJECTIVE: Imaging is recommended to support the clinical diagnoses of dementias, yet imaging research studies rarely have pathological confirmation of disease. This study aims to characterise patterns of brain volume loss in six primary pathologies compared with controls and to each other. METHODS: One hundred and eighty-six patients with a clinical diagnosis of dementia and histopathological confirmation of underlying pathology, and 73 healthy controls were included in this study...
May 4, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28470878/gray-matter-abnormalities-in-idiopathic-parkinson-s-disease-evaluation-by-diffusional-kurtosis-imaging-and-neurite-orientation-dispersion-and-density-imaging
#9
Koji Kamagata, Andrew Zalesky, Taku Hatano, Ryo Ueda, Maria Angelique Di Biase, Ayami Okuzumi, Keigo Shimoji, Masaaki Hori, Karen Caeyenberghs, Christos Pantelis, Nobutaka Hattori, Shigeki Aoki
Mapping gray matter (GM) pathology in Parkinson's disease (PD) with conventional MRI is challenging, and the need for more sensitive brain imaging techniques is essential to facilitate early diagnosis and assessment of disease severity. GM microstructure was assessed with GM-based spatial statistics applied to diffusion kurtosis imaging (DKI) and neurite orientation dispersion imaging (NODDI) in 30 participants with PD and 28 age- and gender-matched controls. These were compared with currently used assessment methods such as diffusion tensor imaging (DTI), voxel-based morphometry (VBM), and surface-based cortical thickness analysis...
May 4, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28464508/limbic-grey-matter-changes-in-early-parkinson-s-disease
#10
Xingfeng Li, Yue Xing, Stefan T Schwarz, Dorothee P Auer
The purpose of this study was to investigate local and network-related changes of limbic grey matter in early Parkinson's disease (PD) and their inter-relation with non-motor symptom severity. We applied voxel-based morphometric methods in 538 T1 MRI images retrieved from the Parkinson's Progression Markers Initiative website. Grey matter densities and cross-sectional estimates of age-related grey matter change were compared between subjects with early PD (n = 366) and age-matched healthy controls (n = 172) within a regression model, and associations of grey matter density with symptoms were investigated...
May 2, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28426817/evaluation-of-machine-learning-algorithms-and-structural-features-for-optimal-mri-based-diagnostic-prediction-in-psychosis
#11
Raymond Salvador, Joaquim Radua, Erick J Canales-Rodríguez, Aleix Solanes, Salvador Sarró, José M Goikolea, Alicia Valiente, Gemma C Monté, María Del Carmen Natividad, Amalia Guerrero-Pedraza, Noemí Moro, Paloma Fernández-Corcuera, Benedikt L Amann, Teresa Maristany, Eduard Vieta, Peter J McKenna, Edith Pomarol-Clotet
A relatively large number of studies have investigated the power of structural magnetic resonance imaging (sMRI) data to discriminate patients with schizophrenia from healthy controls. However, very few of them have also included patients with bipolar disorder, allowing the clinically relevant discrimination between both psychotic diagnostics. To assess the efficacy of sMRI data for diagnostic prediction in psychosis we objectively evaluated the discriminative power of a wide range of commonly used machine learning algorithms (ridge, lasso, elastic net and L0 norm regularized logistic regressions, a support vector classifier, regularized discriminant analysis, random forests and a Gaussian process classifier) on main sMRI features including grey and white matter voxel-based morphometry (VBM), vertex-based cortical thickness and volume, region of interest volumetric measures and wavelet-based morphometry (WBM) maps...
2017: PloS One
https://www.readbyqxmd.com/read/28425061/gray-matter-and-white-matter-changes-in-non-demented-amyotrophic-lateral-sclerosis-patients-with-or-without-cognitive-impairment-a-combined-voxel-based-morphometry-and-tract-based-spatial-statistics-whole-brain-analysis
#12
Foteini Christidi, Efstratios Karavasilis, Franz Riederer, Ioannis Zalonis, Panagiotis Ferentinos, Georgios Velonakis, Sophia Xirou, Michalis Rentzos, Georgios Argiropoulos, Vasiliki Zouvelou, Thomas Zambelis, Athanasios Athanasakos, Panagiotis Toulas, Konstantinos Vadikolias, Efstathios Efstathopoulos, Spyros Kollias, Nikolaos Karandreas, Nikolaos Kelekis, Ioannis Evdokimidis
The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients show structural changes within but also beyond the motor cortex and corticospinal tract and furthermore outside the frontal lobes, even if frank dementia is not detected. The aim of the present study was to investigate both gray matter (GM) and white matter (WM) changes in non-demented amyotrophic lateral sclerosis (ALS) patients with or without cognitive impairment (ALS-motor and ALS-plus, respectively). Nineteen ALS-motor, 31 ALS-plus and 25 healthy controls (HC) underwent 3D-T1-weighted and 30-directional diffusion-weighted imaging on a 3 T MRI scanner...
April 19, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28420876/examining-gray-matter-structure-associated-with-academic-performance-in-a-large-sample-of-chinese-high-school-students
#13
Song Wang, Ming Zhou, Taolin Chen, Xun Yang, Guangxiang Chen, Meiyun Wang, Qiyong Gong
Achievement in school is crucial for students to be able to pursue successful careers and lead happy lives in the future. Although many psychological attributes have been found to be associated with academic performance, the neural substrates of academic performance remain largely unknown. Here, we investigated the relationship between brain structure and academic performance in a large sample of high school students via structural magnetic resonance imaging (S-MRI) using voxel-based morphometry (VBM) approach...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28396646/regional-gray-matter-volume-is-associated-with-restrained-eating-in-healthy-chinese-young-adults-evidence-from-voxel-based-morphometry
#14
Yanhua Su, Todd Jackson, Dongtao Wei, Jiang Qiu, Hong Chen
Highlight Participants were non-clinical young adults with different restrained eating levels.We assessed relations of restrained eating (RE) with regional gray matter volume (rGMV).High RE scores were related to larger GMV in specific areas related to reward.High RE scores were also linked to less GMV in regions related to response inhibition. Objective: Dieting is a popular method of weight control. However, few dieters are able to maintain initial weight losses over an extended period of time. Why do most restrained dieters fail to lose weight? Alterations in brain structures associated with restrained eating (RE) represent one potentially important mechanism that contributes to difficulties in maintaining weight loss within this group...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28394230/advanced-mri-techniques-biomarkers-in-neuropsychiatric-lupus
#15
N Sarbu, P Toledano, A Calvo, E Roura, M I Sarbu, G Espinosa, X Lladó, R Cervera, N Bargalló
Objectives The objective of this study was to determine whether advanced MRI could provide biomarkers for diagnosis and prognosis in neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Our prospective study included 28 systemic lupus erythematosus (SLE) patients with primary central NPSLE, 22 patients without NPSLE and 20 healthy controls. We used visual scales to evaluate atrophy and white matter hyperintensities, voxel-based morphometry and Freesurfer to measure brain volume, plus diffusion-tensor imaging (DTI) to assess white matter (WM) and gray matter (GM) damage...
April 2017: Lupus
https://www.readbyqxmd.com/read/28389386/coordinate-based-random-effect-size-meta-analysis-of-neuroimaging-studies
#16
C R Tench, Radu Tanasescu, C S Constantinescu, D P Auer, W J Cottam
Low power in neuroimaging studies can make them difficult to interpret, and Coordinate based meta-analysis (CBMA) may go some way to mitigating this issue. CBMA has been used in many analyses to detect where published functional MRI or voxel-based morphometry studies testing similar hypotheses report significant summary results (coordinates) consistently. Only the reported coordinates and possibly t statistics are analysed, and statistical significance of clusters is determined by coordinate density. Here a method of performing coordinate based random effect size meta-analysis and meta-regression is introduced...
April 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28387678/memory-is-not-enough-the-neurobiological-substrates-of-dynamic-cognitive-reserve
#17
Laura Serra, Michela Bruschini, Carlotta Di Domenico, Giulia Bechi Gabrielli, Camillo Marra, Carlo Caltagirone, Mara Cercignani, Marco Bozzali
Changes in the residual memory variance are considered as a dynamic aspect of cognitive reserve (d-CR). We aimed to investigate for the first time the neural substrate associated with changes in the residual memory variance overtime in patients with amnestic mild cognitive impairment (aMCI). Thirty-four aMCI patients followed-up for 36 months and 48 healthy elderly individuals (HE) were recruited. All participants underwent 3T MRI, collecting T1-weighted images for voxel-based morphometry (VBM). They underwent an extensive neuropsychological battery, including six episodic memory tests...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28374074/abnormal-subcortical-nuclei-shapes-in-patients-with-type-2-diabetes-mellitus
#18
Ji Chen, Junxiang Zhang, Xuebing Liu, Xiaoyang Wang, Xiangjin Xu, Hui Li, Bo Cao, Yanqiu Yang, Jingjing Lu, Ziqian Chen
OBJECTIVES: Type 2 diabetes mellitus (T2DM) increases the risk of brain atrophy and dementia. We aimed to elucidate deep grey matter (GM) structural abnormalities and their relationships with T2DM cognitive deficits by combining region of interest (ROI)-based volumetry, voxel-based morphometry (VBM) and shape analysis. METHODS: We recruited 23 T2DM patients and 24 age-matched healthy controls to undergo T1-weighted structural MRI scanning. Images were analysed using the three aforementioned methods to obtain deep GM structural shapes and volumes...
April 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28370153/mri-reveals-therapeutical-efficacy-of-stem-cells-an-experimental-study-on-the-sod1-g93a-animal-model
#19
Pietro Bontempi, Alice Busato, Roberta Bonafede, Lorenzo Schiaffino, Ilaria Scambi, Andrea Sbarbati, Raffaella Mariotti, Pasquina Marzola
PURPOSE: The first part of the experiment identifies and validates MRI biomarkers distinctive of the disease progression in the transgenic superoxide dismutase gene (SOD1(G93A)) animal model. The second part assesses the efficacy of a mesenchymal stem cell-based therapy through the MRI biomarkers previously defined. METHODS: The first part identifies MRI differences between SOD1(G93A) and healthy mice. The second part of the experiment follows the disease evolution of stem cell-treated and non-stem-cell treated SOD1(G93A) mice...
March 31, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28351446/on-the-relationship-between-head-circumference-brain-size-prenatal-long-chain-pufa-5-methyltetrahydrofolate-supplementation-and-cognitive-abilities-during-childhood
#20
Andrés Catena, Cristina Martínez-Zaldívar, Carolina Diaz-Piedra, Francisco J Torres-Espínola, Pilar Brandi, Miguel Pérez-García, Tamás Decsi, Berthold Koletzko, Cristina Campoy
Head circumference in infants has been reported to predict brain size, total grey matter volume (GMV) and neurocognitive development. However, it is unknown whether it has predictive value on regional and subcortical brain volumes. We aimed to explore the relationship between several head circumference measurements since birth and distributions of GMV and subcortical volumes at later childhood. We examined seventy-four, Caucasian, singleton, term-born infants born to mothers randomised to receive fish oil and/or 5-methyltetrahydrofolate or placebo prenatal supplementation...
March 29, 2017: British Journal of Nutrition
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