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Voxel based morphometry MRI

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https://www.readbyqxmd.com/read/29782369/neuroimaging-in-epilepsy
#1
Meneka Kaur Sidhu, John S Duncan, Josemir W Sander
PURPOSE OF REVIEW: Epilepsy neuroimaging is important for detecting the seizure onset zone, predicting and preventing deficits from surgery and illuminating mechanisms of epileptogenesis. An aspiration is to integrate imaging and genetic biomarkers to enable personalized epilepsy treatments. RECENT FINDINGS: The ability to detect lesions, particularly focal cortical dysplasia and hippocampal sclerosis, is increased using ultra high-field imaging and postprocessing techniques such as automated volumetry, T2 relaxometry, voxel-based morphometry and surface-based techniques...
May 17, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29773998/larger-gray-matter-volume-in-the-basal-ganglia-of-heavy-cannabis-users-detected-by-voxel-based-morphometry-and-subcortical-volumetric-analysis
#2
Ana Moreno-Alcázar, Begoña Gonzalvo, Erick J Canales-Rodríguez, Laura Blanco, Diana Bachiller, Anna Romaguera, Gemma C Monté-Rubio, Carlos Roncero, Peter J McKenna, Edith Pomarol-Clotet
Background: Structural imaging studies of cannabis users have found evidence of both cortical and subcortical volume reductions, especially in cannabinoid receptor-rich regions such as the hippocampus and amygdala. However, the findings have not been consistent. In the present study, we examined a sample of adult heavy cannabis users without other substance abuse to determine whether long-term use is associated with brain structural changes, especially in the subcortical regions. Method: We compared the gray matter volume of 14 long-term, heavy cannabis users with non-using controls...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29755611/morphological-biomarker-differentiating-mci-converters-from-nonconverters-longitudinal-evidence-based-on-hemispheric-asymmetry
#3
Xiaojing Long, Chunxiang Jiang, Lijuan Zhang
Identifying subjects with mild cognitive impairment (MCI) who may probably progress to Alzheimer's disease (AD) is important for better understanding the disease mechanisms and facilitating early treatments. In addition to the direct volumetric and thickness measurement based on high-resolution magnetic resonance imaging (MRI), hemispheric asymmetry could be a potential index to detect morphological variations in MCI patients with a high risk of conversion to AD. The present study collected a set of longitudinal MRI data from 53 MCI converters and nonconverters and investigated the asymmetry differences between groups...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/29754151/a-voxel-based-magnetic-resonance-imaging-morphometric-study-of-cerebral-and-cerebellar-gray-matter-in-patients-under-65-years-with-essential-tremor
#4
Hongmei Cao, Rong Wang, Xue Luo, Xianjun Li, Mark Hallett, Johanna Thompson-Westra, Jian Yang, Qiumin Qu, Xiaobo Yang
BACKGROUND The aim of this study was to compare the morphological changes in cerebral and cerebellar gray matter in patients with essential tremor under 60-years-of-age, with age-matched and gender-matched normal healthy volunteer control subjects, using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM) analysis. MATERIAL AND METHODS A retrospective, controlled, comparative clinical study included 17 patients with essential tremor, <60 years-of-age, and 17 age-matched and gender-matched healthy volunteer control subjects, recruited between June 2010-July 2012...
May 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29740296/distinguishing-adolescents-with-conduct-disorder-from-typically-developing-youngsters-based-on-pattern-classification-of-brain-structural-mri
#5
Jianing Zhang, Weixiang Liu, Jing Zhang, Qiong Wu, Yidian Gao, Yali Jiang, Junling Gao, Shuqiao Yao, Bingsheng Huang
Background: Conduct disorder (CD) is a mental disorder diagnosed in childhood or adolescence that presents antisocial behaviors, and is associated with structural alterations in brain. However, whether these structural alterations can distinguish CD from healthy controls (HCs) remains unknown. Here, we quantified these structural differences and explored the classification ability of these quantitative features based on machine learning (ML). Materials and Methods: High-resolution 3D structural magnetic resonance imaging (sMRI) was acquired from 60 CD subjects and 60 age-matched HCs...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29707531/morphometric-magnetic-resonance-imaging-study-in-children-with-primary-monosymptomatic-nocturnal-enuresis
#6
Mengxing Wang, Anyi Zhang, Jilei Zhang, Haifeng Lu, Shuai Xu, Zhaoxia Qin, Jun Ma, Xiaoxia Du
Objective: Primary monosymptomatic nocturnal enuresis (PMNE) refers to bed-wetting in children who have no other lower urinary tract symptoms and are never dry for more than 6 months. Our previous studies demonstrated that children with PMNE exhibited brain functional abnormalities compared with healthy controls; however, researches on the abnormalities in gray matter were limited. This study aimed to investigate brain structural changes in gray matter of children with PMNE using magnetic resonance imaging (MRI)...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29704671/apathy-in-alzheimer-s-disease-and-frontotemporal-dementia-distinct-clinical-profiles-and-neural-correlates
#7
Fiona Kumfor, Alice Zhen, John R Hodges, Olivier Piguet, Muireann Irish
OBJECTIVE: Apathy is the most prevalent and disabling non-cognitive symptom of dementia and affects 90% of patients across the disease course. Despite its pervasiveness, how apathy manifests across dementia syndromes and the neurobiological mechanisms driving these symptoms are poorly understood. Here, we applied the multidimensional ABC model of apathy, which recognizes Affective, Behavioural and Cognitive apathy, in Alzheimer's disease (AD) and behavioural-variant frontotemporal dementia (bvFTD)...
March 29, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29696595/delay-discounting-mediates-the-association-between-posterior-insular-cortex-volume-and-social-media-addiction-symptoms
#8
Ofir Turel, Qinghua He, Damien Brevers, Antoine Bechara
Addiction-like symptoms in relation to excessive and compulsive social media use are common in the general population. Because they can lead to various adverse effects, there is a growing need to understand the brain systems and processes that are involved in potential social media addiction. We focus on the morphology of the posterior subdivision of the insular cortex (i.e., the insula), because it has been shown to be instrumental to supporting the maintenance of substance addictions and problematic behaviors...
April 25, 2018: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29695908/the-functional-and-structural-characteristics-of-the-emotion-network-in-alexithymia
#9
Dai Han, Mei Li, Minjun Mei, Xiaofei Sun
Background: Alexithymia is a multifaceted personality trait characterized by emotional dysfunction. Methods: In this study, the functional and structural features of the emotion network in alexithymia were investigated using resting-state functional MRI (rsfMRI), voxel-based morphometry (VBM), functional connectivity (FC) analysis, and diffusion tensor imaging (DTI). Alexithymic and non-alexithymic students were recruited from the local university. The intrinsic neural activity and gray matter density of the brain regions in the emotion network were measured using rsfMRI and VBM; the FC and structural connectivity of the brain regions in the emotion network were measured using FC analysis and DTI...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29691468/large-scale-brain-network-associated-with-creative-insight-combined-voxel-based-morphometry-and-resting-state-functional-connectivity-analyses
#10
Takeshi Ogawa, Takatsugu Aihara, Takeaki Shimokawa, Okito Yamashita
Creative insight occurs with an "Aha!" experience when solving a difficult problem. Here, we investigated large-scale networks associated with insight problem solving. We recruited 232 healthy participants aged 21-69 years old. Participants completed a magnetic resonance imaging study (MRI; structural imaging and a 10 min resting-state functional MRI) and an insight test battery (ITB) consisting of written questionnaires (matchstick arithmetic task, remote associates test, and insight problem solving task)...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29688873/assessing-the-marks-of-change-how-psychotherapy-alters-the-brain-structure-in-women-with-borderline-personality-disorder
#11
Falk Mancke, Ruth Schmitt, Dorina Winter, Inga Niedtfeld, Sabine C Herpertz, Christian Schmahl
BACKGROUND: There is increasing evidence that psychotherapy can alter the function of the brain of patients with borderline personality disorder (BPD). However, it is not known whether psychotherapy can also modify the brain structure of patients with BPD. METHODS: We used structural MRI data of female patients with BPD before and after participation in 12 weeks of residential dialectical behavioural therapy (DBT) and compared them to data from female patients with BPD who received treatment as usual (TAU)...
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29687532/altered-structural-and-functional-connectivity-of-the-insula-in-functional-dyspepsia
#12
P Liu, Y Fan, Y Wei, F Zeng, R Li, N Fei, W Qin
BACKGROUND: Functional dyspepsia (FD) is a common functional gastrointestinal disease. Neuroimaging studies have identified that insula is involved in the pathogenesis of FD. However, less is known about structural and functional connectivity of insula in FD. METHODS: In this study, 67 FD patients and 46 healthy controls (HCs) underwent structural MRI, resting-state functional MRI, diffusion tensor imaging (DTI) scans, and clinical assessment. We used the 3 neuroimaging modalities to investigate structural and functional connectivity of insula between FD patients and HCs, and we examined relationships between the neuroimaging findings and clinical symptoms...
April 23, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29673867/structural-differences-in-hippocampal-and-entorhinal-gray-matter-volume-support-individual-differences-in-first-person-navigational-ability
#13
Katherine R Sherrill, Elizabeth R Chrastil, Irem Aselcioglu, Michael E Hasselmo, Chantal E Stern
The ability to update position and orientation to reach a goal is crucial to spatial navigation and individuals vary considerably in this ability. The current structural MRI study used voxel-based morphometry (VBM) analysis to relate individual differences in human brain morphology to performance in an active navigation task that relied on updating position and orientation in a landmark-free environment. Goal-directed navigation took place from either a first person perspective, similar to a person walking through the landmark-free environment, or Survey perspective, a bird's eye view...
April 16, 2018: Neuroscience
https://www.readbyqxmd.com/read/29648977/severe-tbi-patients-without-focal-lesion-but-with-behavioral-disorders-shrinkage-of-gray-matter-nuclei-and-thalamus-revealed-in-a-pilot-voxel-based-mri-study
#14
Alexis Ruet, Françoise Joyeux, Shailandra Segobin, Corinne Jokic, Béatrice Desgranges, Francis Eustache, Anne-Lise Pitel
After a traumatic brain injury (TBI), behavioral disorders can occur without major focal brain lesion and in this case, their pathophysiology remains unclear. The aim of this study is to examine whether TBI patients with behavioral disorders but without any focal damage, as observed from an initial clinical CT scan, present subtle volumetric alterations that could be measured voxel-by-voxel in the whole brain with magnetic resonance imaging (MRI). Eight severe TBI male adults with behavioral sequela but without major focal cerebral lesion and 17 age-matched controls underwent a volumetric T1-weighted 1...
March 6, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29629981/abnormal-gray-matter-asymmetry-in-alcohol-dependence
#15
Jiajia Zhu, Yajun Wang, Haibao Wang, Wenwen Cheng, Zipeng Li, Yinfeng Qian, Xiaohu Li, Xiaoshu Li, Yongqiang Yu
Previous voxel-based morphometry studies have provided evidence that patients with alcohol dependence (AD) have widespread gray matter morphological abnormalities. However, brain structural asymmetry in AD has not been assessed to date. Here, we aimed to use a recently developed voxel-based morphometry-based approach to investigate global and regional gray matter asymmetry alterations in AD. A total of 39 male individuals, including 19 AD patients and 20 age-matched healthy controls, underwent high-resolution structural MRI...
April 6, 2018: Neuroreport
https://www.readbyqxmd.com/read/29629501/gray-matter-volume-covariance-patterns-associated-with-gait-speed-in-older-adults-a-multi-cohort-mri-study
#16
Helena M Blumen, Lucy L Brown, Christian Habeck, Gilles Allali, Emmeline Ayers, Olivier Beauchet, Michele Callisaya, Richard B Lipton, P S Mathuranath, Thanh G Phan, V G Pradeep Kumar, Velandai Srikanth, Joe Verghese
Accelerated gait decline in aging is associated with many adverse outcomes, including an increased risk for falls, cognitive decline, and dementia. Yet, the brain structures associated with gait speed, and how they relate to specific cognitive domains, are not well-understood. We examined structural brain correlates of gait speed, and how they relate to processing speed, executive function, and episodic memory in three non-demented and community-dwelling older adult cohorts (Overall N = 352), using voxel-based morphometry and multivariate covariance-based statistics...
April 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29628269/cerebellar-abnormalities-in-first-episode-drug-naive-schizophrenia-at-rest
#17
Wenbin Guo, Fengyu Zhang, Feng Liu, Jindong Chen, Renrong Wu, Danny Q Chen, Zhikun Zhang, Jinguo Zhai, Jingping Zhao
The cerebellum plays a crucial role in higher cortical functions through a cerebellar-cerebral circuit. However, the specific mechanisms through which the cerebellum contributes to the neurobiology of schizophrenia remain unclear. Forty-nine first-episode, drug-naive patients with schizophrenia and 50 healthy controls underwent structural and resting-state functional magnetic resonance imaging (rs-fMRI). The MRI data were analyzed using voxel-based morphometry, amplitude of low-frequency fluctuations (ALFF), cerebellum homogeneity (CH), and seed-based functional connectivity (FC)...
March 29, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29628218/effects-of-sex-hormones-and-age-on-brain-volume-in-post-menopausal-women
#18
Gwang-Won Kim, Kwangsung Park, Gwang-Woo Jeong
BACKGROUND: Investigation of the effect of sex hormones on the brain volume in women provides a unique opportunity to examine menopause-related morphometric alterations. AIM: To evaluate brain morphological alterations in post-menopausal women using voxel-based morphometry and its correlations with sex hormone levels. METHODS: 20 Pre-menopausal women and 20 post-menopausal women underwent structural MRI. OUTCOMES: T1-weighted magnetic resonance data were acquired and serum sex hormones including total estrogen, estriol, estradiol (E2), follicle-stimulating hormone, free testosterone, SHBG, and luteinizing hormone were measured...
April 5, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29620511/gray-matter-volume-changes-over-the-whole-brain-in-the-bulbar-and-spinal-onset-amyotrophic-lateral-sclerosis-a-voxel-based-morphometry-study
#19
Zhi-Ye Chen, Meng-Qi Liu, Lin Ma
Objective To investigate cerebral structural signatures of the bulbar- and spinal-onset amyotrophic lateral sclerosis (ALS) using voxel-based morphometry on magnetic resonance imaging. Methods The MR structural images of the brain were obtained from 65 ALS patients (15 bulbar-onset, 50 spinal-onset) and 65 normal controls (NC) on a 3.0T MRI system. Gray matter (GM) volume changes were investigated by voxel-based morphometry, and the distribution of the brain regions with volume changes was compared between ALS and normal controls, as well as between bulbar-onset and spinal-onset ALS based on Neuromorphometrics atlas...
March 30, 2018: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29614645/structural-anatomical-investigation-of-long-term-memory-deficit-in-behavioral-frontotemporal-dementia
#20
Maxime Bertoux, Emma C Flanagan, Matthew Hobbs, Amparo Ruiz-Tagle, Carolina Delgado, Marcelo Miranda, Agustín Ibáñez, Andrea Slachevsky, Michael Hornberger
Although a growing body of work has shown that behavioral variant frontotemporal dementia (bvFTD) could present with severe amnesia in approximately half of cases, memory assessment is currently the clinical standard to distinguish bvFTD from Alzheimer's disease (AD). Thus, the concept of "relatively preserved episodic memory" in bvFTD remains the basis of its clinical distinction from AD and a criterion for bvFTD's diagnosis. This view is supported by the idea that bvFTD is not characterized by genuine amnesia and hippocampal degeneration, by contrast to AD...
March 24, 2018: Journal of Alzheimer's Disease: JAD
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