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Voxel based morphometry MRI

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https://www.readbyqxmd.com/read/27919546/brain-morphometry-predicts-individual-creative-potential-and-the-ability-to-combine-remote-ideas
#1
David Bendetowicz, Marika Urbanski, Clarisse Aichelburg, Richard Levy, Emmanuelle Volle
For complex mental functions such as creative thinking, inter-individual variability is useful to better understand the underlying cognitive components and brain anatomy. Associative theories propose that creative individuals have flexible semantic associations, which allows remote elements to be formed into new combinations. However, the structural brain variability associated with the ability to combine remote associates has not been explored. To address this question, we performed a voxel-based morphometry (VBM) study and explored the anatomical connectivity of significant regions...
November 15, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27916985/the-obese-brain-as-a-heritable-phenotype-a-combined-morphometry-and-twin-study
#2
C M Weise, P Piaggi, M Reinhardt, K Chen, C R Savage, J Krakoff, B Pleger
BACKGROUND: Body weight and adiposity are heritable traits. To date it remains unknown whether obesity-associated brain structural alterations are under a similar level of genetic control. METHODS: For this study we utilized magnetic resonance imaging (MRI) data from the Human Connectome Project. Voxel based morphometry (VBM) was used to investigate associations between body mass index (BMI) and regional gray matter volume (GMV) in a sample of 875 young adults with a wide BMI range (386m/489f; age 28...
December 5, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27911301/tau-platelets-correlate-with-regional-brain%C3%A2-atrophy-in-patients-with-alzheimer-s%C3%A2-disease
#3
Andrea Slachevsky, Leonardo Guzmán-Martínez, Carolina Delgado, Pablo Reyes, Gonzalo A Farías, Carlos Muñoz-Neira, Eduardo Bravo, Mauricio Farías, Patricia Flores, Cristian Garrido, James T Becker, Oscar L López, Ricardo B Maccioni
BACKGROUND: Intracellular neurofibrillary tangles are part of the core pathology of Alzheimer's disease (AD), which are mainly composed of hyperphosphorylated tau protein. OBJECTIVES: The purpose of this study is to determine whether high molecular weight (HMW) or low molecular weight (LMW) tau protein levels, as well as the ratio HMW/LMW, present in platelets correlates with brain magnetic resonance imaging (MRI) structural changes in normal and cognitively impaired subjects...
November 26, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27905410/association-between-preterm-brain-injury-and-exposure-to-chorioamnionitis-during-fetal-life
#4
Devasuda Anblagan, Rozalia Pataky, Margaret J Evans, Emma J Telford, Ahmed Serag, Sarah Sparrow, Chinthika Piyasena, Scott I Semple, Alastair Graham Wilkinson, Mark E Bastin, James P Boardman
Preterm infants are susceptible to inflammation-induced white matter injury but the exposures that lead to this are uncertain. Histologic chorioamnionitis (HCA) reflects intrauterine inflammation, can trigger a fetal inflammatory response, and is closely associated with premature birth. In a cohort of 90 preterm infants with detailed placental histology and neonatal brain magnetic resonance imaging (MRI) data at term equivalent age, we used Tract-based Spatial Statistics (TBSS) to perform voxel-wise statistical comparison of fractional anisotropy (FA) data and computational morphometry analysis to compute the volumes of whole brain, tissue compartments and cerebrospinal fluid, to test the hypothesis that HCA is an independent antenatal risk factor for preterm brain injury...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893017/evaluation-of-cognitive-deficits-and-structural-hippocampal-damage-in-encephalitis-with-leucine-rich-glioma-inactivated-1-antibodies
#5
Carsten Finke, Harald Prüss, Josephine Heine, Sigrid Reuter, Ute A Kopp, Florian Wegner, Florian Then Bergh, Sebastian Koch, Olav Jansen, Thomas Münte, Günther Deuschl, Klemens Ruprecht, Winfried Stöcker, Klaus-Peter Wandinger, Friedemann Paul, Thorsten Bartsch
Importance: Limbic encephalitis with leucine-rich, glioma-inactivated 1 (LGI1) antibodies is one of the most frequent variants of autoimmune encephalitis with antibodies targeting neuronal surface antigens. However, the neuroimaging pattern and long-term cognitive outcome are not well understood. Objective: To study cognitive outcome and structural magnetic resonance imaging (MRI) alterations in patients with anti-LGI1 encephalitis. Design, Setting, and Participants: A cross-sectional study was conducted at the Departments of Neurology at Charité-Universitätsmedizin Berlin and University Hospital Schleswig-Holstein, Kiel, Germany...
November 21, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27888657/electroconvulsive-therapy-induced-brain-structural-and-functional-changes-in-major-depressive-disorders-a-longitudinal-study
#6
Haitang Qiu, Xirong Li, Wenjing Zhao, Lian Du, Peiyu Huang, Yixiao Fu, Tian Qiu, Peng Xie, Huaqing Meng, Qinghua Luo
BACKGROUND This study aimed to study the brain structural and functional changes after 8 courses of electroconvulsive therapy (ECT) on patients with major depressive disorder (MDD). MATERIAL AND METHODS MRI scans were performed on 12 depressive patients before and after 8 courses of ECT and compared with those of 15 normal controls. Data were analyzed by voxel-based morphometry (VBM) using SPM8 software. Functional MRI (fMRI) and regional homogeneity (ReHo) analyses were used to assess the functional changes after ECT...
November 26, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27888414/structural-brain-abnormalities-in-patients-with-vestibular-migraine
#7
Roberta Messina, Maria A Rocca, Bruno Colombo, Roberto Teggi, Andrea Falini, Giancarlo Comi, Massimo Filippi
New advances in understanding the pathophysiology of vestibular migraine (VM) have suggested a large overlap between migraine and vestibular pathways. We explored the regional distribution of gray (GM) and white matter (WM) abnormalities in VM patients in comparison to migraine patients with (MWA) and without aura (MWoA) and their correlations with patients' clinical manifestations. Using a 3.0 Tesla scanner, brain T2-weighted and 3D T1-weighted MRI scans were acquired from 19 VM, 19 MWA, 19 MWoA and 20 age-matched controls...
November 25, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27887721/comparative-multimodal-meta-analysis-of-structural-and-functional-brain-abnormalities-in-autism-spectrum-disorder-and-obsessive-compulsive-disorder
#8
Christina O Carlisi, Luke J Norman, Steve S Lukito, Joaquim Radua, David Mataix-Cols, Katya Rubia
BACKGROUND: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) share inhibitory control deficits possibly underlying poor control over stereotyped and repetitive g., v/r/ dACC /MPFC); and (iv) to indicate a pathway (e.g., if this is a pathway: bilateral putamen/caudate/nucleus accumbens / pallidum /amygdala/insula). BPS style does not allow virgules to be used to represent expressions of duality or alternatives. Please express these as and/or, and, or or . BPS style does not allow virgules to be used to represent a compound modifier such as "rostral/ dorsomedial ," which should be changed to hyphen(s), such as rostral- dorsomedial ...
October 13, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27853938/differential-pattern-of-cerebellar-atrophy-in-tremor-predominant-and-akinetic-rigidity-predominant-parkinson-s-disease
#9
Camila Callegari Piccinin, Lidiane Soares Campos, Rachel Paes Guimarães, Luiza Gonzaga Piovesana, Maria Cristina Arci Dos Santos, Paula Christina Azevedo, Brunno Machado Campos, Thiago Junqueira Ribeiro de Rezende, Augusto Amato-Filho, Fernando Cendes, Anelyssa D'Abreu
Parkinson's disease (PD) is an akinetic-rigid disorder characterized by basal ganglia dysfunction and a possible cerebello-thalamo-cortical circuit involvement. This study aims to investigate the pattern of cerebellar involvement in PD and to assess whether it correlates with clinical parameters. MRI scans were acquired from 50 healthy controls (HC) and 63 patients; 44 were classified as tremor-predominant-PD (PDT) and 19 as akinetic/rigidity-predominant-PD (PDAR). We designed an analysis of covariance including the three groups and contrasted as follows: (1) all 63 PD vs HC, (2) PDT vs HC, (3) PDAR vs HC, and (4) PDT vs PDAR...
November 16, 2016: Cerebellum
https://www.readbyqxmd.com/read/27844498/adolescents-newly-diagnosed-with-eating-disorders-have-structural-differences-in-brain-regions-linked-with-eating-disorder-symptoms
#10
Linda Solstrand Dahlberg, Lyle Wiemerslage, Ingemar Swenne, Anna Larsen, Julia Stark, Mathias Rask-Andersen, Helena Salonen-Ros, Elna-Marie Larsson, Helgi B Schiöth, Samantha J Brooks
BACKGROUND: Adults with eating disorders (ED) show brain volume reductions in the frontal, insular, cingulate, and parietal cortices, as well as differences in subcortical regions associated with reward processing. However, little is known about the structural differences in adolescents with behavioural indications of early stage ED. AIM: This is the first study to investigate structural brain changes in adolescents newly diagnosed with ED compared to healthy controls (HC), and to study whether ED cognitions correlate with structural changes in adolescents with ED of short duration...
November 15, 2016: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/27844456/cortical-plasticity-between-the-pain-and-pain-free-phases-in-patients-with-episodic-tension-type-headache
#11
Bing Chen, Yuan He, Lei Xia, Li-Li Guo, Jin-Long Zheng
BACKGROUND: State-related brain structural alterations in patients with episodic tension-type headache (ETTH) are unclear. We aimed to conduct a longitudinal study to explore dynamic gray matter (GM) changes between the pain and pain-free phases in ETTH. METHODS: We recruited 40 treatment-naïve ETTH patients and 40 healthy controls. All participants underwent brain structural scans on a 3.0-T MRI system. ETTH patients were scanned in and out of pain phases. Voxel-based morphometry analysis was used to determine the differences in regional gray matter density (GMD) between groups...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27843694/grey-matter-abnormalities-in-methcathinone-abusers-with-a-parkinsonian-syndrome
#12
Julius Juurmaa, Ricarda A L Menke, Pierre Vila, Andreas Müürsepp, Tiiu Tomberg, Pilvi Ilves, Mait Nigul, Heidi Johansen-Berg, Michael Donaghy, Charlotte J Stagg, Ainārs Stepens, Pille Taba
BACKGROUND: A permanent Parkinsonian syndrome occurs in intravenous abusers of the designer psychostimulant methcathinone (ephedrone). It is attributed to deposition of contaminant manganese, as reflected by characteristic globus pallidus hyperintensity on T1-weighted MRI. METHODS: We have investigated brain structure and function in methcathinone abusers (n = 12) compared to matched control subjects (n = 12) using T1-weighted structural and resting-state functional MRI...
November 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27833549/impaired-white-matter-connections-of-the-limbic-system-networks-associated-with-impaired-emotional-memory-in-alzheimer-s-disease
#13
Xiaoshu Li, Haibao Wang, Yanghua Tian, Shanshan Zhou, Xiaohu Li, Kai Wang, Yongqiang Yu
Background: Discrepancies persist regarding retainment of emotional enhancement of memory (EEM) in mild cognitive impairment (MCI) and early Alzheimer's disease (AD) patients.In addition, the neural mechanisms are still poorly understood, little is known about emotional memory related changes in white matter (WM). Objective: To observe whether EEM is absent in amnestic MCI (aMCI) and AD patients, and to investigate if emotional memory is associated with WM connections and gray matters (GM) of the limbic system networks...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27812347/t2-imaging-changes-in-the-nigrosome-1-relate-to-clinical-measures-of-parkinson-s-disease
#14
Katherine A Fu, Romil Nathan, Ivo D Dinov, Junning Li, Arthur W Toga
BACKGROUND: The nigrosome-1 region of the substantia nigra (SN) undergoes the greatest and earliest dopaminergic neuron loss in Parkinson's disease (PD). As T2-weighted magnetic resonance imaging (MRI) scans are often collected with routine clinical MRI protocols, this investigation aims to determine whether T2-imaging changes in the nigrosome-1 are related to clinical measures of PD and to assess their potential as a more clinically accessible biomarker for PD. METHODS: Voxel intensity ratios were calculated for T2-weighted MRI scans from 47 subjects from the Parkinson's Progression Markers Initiative database...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27802229/diverging-progression-of-network-disruption-and-atrophy-in-alzheimer-s-disease-and-semantic-dementia
#15
Jennifer Andreotti, Thomas Dierks, Lars-Olof Wahlund, Matthias Grieder
The progression of cognitive deficits in Alzheimer's disease and semantic dementia is accompanied by grey matter atrophy and white matter deterioration. The impact of neuronal loss on the structural network connectivity in these dementia subtypes is, however, not well understood. In order to gain a more refined knowledge of the topological organization of white matter alterations in dementia, we used a network-based approach to analyze the brain's structural connectivity network. Diffusion-weighted and anatomical MRI images of groups with eighteen Alzheimer's disease and six semantic dementia patients, as well as twenty-one healthy controls were recorded to reconstruct individual connectivity networks...
October 12, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27790103/a-voxel-based-morphometry-study-reveals-local-brain-structural-alterations-associated-with-ambient-fine-particles-in-older-women
#16
Ramon Casanova, Xinhui Wang, Jeanette Reyes, Yasuyuki Akita, Marc L Serre, William Vizuete, Helena C Chui, Ira Driscoll, Susan M Resnick, Mark A Espeland, Jiu-Chiuan Chen
Objective: Exposure to ambient fine particulate matter (PM2.5: PM with aerodynamic diameters < 2.5 μm) has been linked with cognitive deficits in older adults. Using fine-grained voxel-wise analyses, we examined whether PM2.5 exposure also affects brain structure. Methods: Brain MRI data were obtained from 1365 women (aged 71-89) in the Women's Health Initiative Memory Study and local brain volumes were estimated using RAVENS (regional analysis of volumes in normalized space). Based on geocoded residential locations and air monitoring data from the U...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27787929/compulsive-sexual-behavior-prefrontal-and-limbic-volume-and-interactions
#17
Casper Schmidt, Laurel S Morris, Timo L Kvamme, Paula Hall, Thaddeus Birchard, Valerie Voon
BACKGROUND: Compulsive sexual behaviors (CSB) are relatively common and associated with significant personal and social dysfunction. The underlying neurobiology is still poorly understood. The present study examines brain volumes and resting state functional connectivity in CSB compared with matched healthy volunteers (HV). METHODS: Structural MRI (MPRAGE) data were collected in 92 subjects (23 CSB males and 69 age-matched male HV) and analyzed using voxel-based morphometry...
October 27, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27785699/cerebellar-involvement-in-patients-with-mild-to-moderate-myoclonus-due-to-epm1-structural-and-functional-mri-findings-in-comparison-with-healthy-controls-and-ataxic-patients
#18
Anna Nigri, Elisa Visani, Nicola Bertolino, Lorenzo Nanetti, Caterina Mariotti, Marta Panzeri, Maria Grazia Bruzzone, Silvana Franceschetti, Laura Canafoglia
EPM1 (epilepsy, progressive myoclonic 1; Unverricht-Lundborg disease, OMIM #254800) is the most frequent form of progressive myoclonus epilepsy. Previous findings have suggested that its pathophysiology mainly involves the cerebellum, but the evaluation of cerebellar dysfunction is still unsatisfactory. The aim of this study was to assess the structural and functional involvement of the cerebellum in EPM1. We used voxel-based morphometry and spatially unbiased infra-tentorial template analyses of structural magnetic resonance imaging (MRI) scans, and functional MRI (fMRI) scans during block and event-related go/no-go motor tasks to study 13 EPM1 patients with mild to moderate myoclonus...
October 26, 2016: Brain Topography
https://www.readbyqxmd.com/read/27777415/brain-structure-in-pediatric-tourette-syndrome
#19
D J Greene, A C Williams Iii, J M Koller, B L Schlaggar, K J Black
Previous studies of brain structure in Tourette syndrome (TS) have produced mixed results, and most had modest sample sizes. In the present multicenter study, we used structural magnetic resonance imaging (MRI) to compare 103 children and adolescents with TS to a well-matched group of 103 children without tics. We applied voxel-based morphometry methods to test gray matter (GM) and white matter (WM) volume differences between diagnostic groups, accounting for MRI scanner and sequence, age, sex and total GM+WM volume...
October 25, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27771043/tracking-the-development-of-agrammatic-aphasia-a-tensor-based-morphometry-study
#20
Jennifer L Whitwell, Joseph R Duffy, Mary M Machulda, Heather M Clark, Edythe A Strand, Matthew L Senjem, Jeffrey L Gunter, Anthony J Spychalla, Ronald C Petersen, Clifford R Jack, Keith A Josephs
Agrammatic aphasia can be observed in neurodegenerative disorders and has been traditionally linked with damage to Broca's area, although there have been disagreements concerning whether damage to Broca's area is necessary or sufficient for the development of agrammatism. We aimed to investigate the neuroanatomical correlates of the emergence of agrammatic aphasia utilizing a unique cohort of patients with primary progressive apraxia of speech (PPAOS) that did not have agrammatism at baseline but developed agrammatic aphasia over time...
September 30, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
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