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Voxel based morphometry MRI

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https://www.readbyqxmd.com/read/28332625/brain-anatomy-alterations-associated-with-social-networking-site-sns-addiction
#1
Qinghua He, Ofir Turel, Antoine Bechara
This study relies on knowledge regarding the neuroplasticity of dual-system components that govern addiction and excessive behavior and suggests that alterations in the grey matter volumes, i.e., brain morphology, of specific regions of interest are associated with technology-related addictions. Using voxel based morphometry (VBM) applied to structural Magnetic Resonance Imaging (MRI) scans of twenty social network site (SNS) users with varying degrees of SNS addiction, we show that SNS addiction is associated with a presumably more efficient impulsive brain system, manifested through reduced grey matter volumes in the amygdala bilaterally (but not with structural differences in the Nucleus Accumbens)...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327107/brain-structure-differences-among-male-schizophrenic-patients-with-history-of-serious-violent-acts-an-mri-voxel-based-morphometric-study
#2
Noriomi Kuroki, Hiroko Kashiwagi, Miho Ota, Masanori Ishikawa, Hiroshi Kunugi, Noriko Sato, Naotsugu Hirabayashi, Toshio Ota
BACKGROUND: The biological underpinnings of serious violent behaviors in patients with schizophrenia remain unclear. The aim of this study was to identify the characteristics of brain morphometry in patients with schizophrenia and a history of serious violent acts, who were being treated under relatively new legislation for offenders with mental illness in Japan where their relevant action should be strongly associated with their mental illness. We also investigated whether morphometric changes would depend on types of serious violent actions or not...
March 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28326008/disease-specific-regions-outperform-whole-brain-approaches-in-identifying-progressive-supranuclear-palsy-a-multicentric-mri-study
#3
Karsten Mueller, Robert Jech, Cecilia Bonnet, Jaroslav Tintěra, Jaromir Hanuška, Harald E Möller, Klaus Fassbender, Albert Ludolph, Jan Kassubek, Markus Otto, Evžen Růžička, Matthias L Schroeter
To identify progressive supranuclear palsy (PSP), we combined voxel-based morphometry (VBM) and support vector machine (SVM) classification using disease-specific features in multicentric magnetic resonance imaging (MRI) data. Structural brain differences were investigated at four centers between 20 patients with PSP and 20 age-matched healthy controls with T1-weighted MRI at 3T. To pave the way for future application in personalized medicine, we applied SVM classification to identify PSP on an individual level besides group analyses based on VBM...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28321185/sex-matters-hippocampal-volume-predicts-individual-differences-in-associative-memory-in-cognitively-normal-older-women-but-not-men
#4
Zhiwei Zheng, Rui Li, Fengqiu Xiao, Rongqiao He, Shouzi Zhang, Juan Li
The hippocampus plays a prominent role in associative memory by supporting relational binding and recollection processes. Structural atrophy in the hippocampus is likely to induce associative memory deficits in older adults. Previous studies have primarily focused on average age-related differences in hippocampal structure and memory performance. To date, however, it remains unclear whether individual differences in hippocampal morphometry underlie differential associative memory performance, and whether there are sex differences in the structural correlates of associative memory in healthy older adults...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28319687/effects-of-subclinical-depression-anxiety-and-somatization-on-brain-structure-in-healthy-subjects
#5
Bianca Besteher, Christian Gaser, Kerstin Langbein, Maren Dietzek, Heinrich Sauer, Igor Nenadić
BACKGROUND: Dimensional approaches in highly prevalent psychiatric disorders like depression or anxiety could lead to a better understanding of pathogenesis and advantages in early detection and prevention. In an effort to better understand associations of brain structural variation across the depression/anxiety spectra, we investigated minor subclinical symptoms in a non-clinical healthy population. METHODS: We studied 177 healthy subjects from the community, who underwent high-resolution T1-weighted 3T MRI and completed the symptom-checklist-90 (SCL-90-R)...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28303917/reduced-regional-grey-matter-volumes-in-pediatric-obstructive-sleep-apnea
#6
Mona F Philby, Paul M Macey, Richard A Ma, Rajesh Kumar, David Gozal, Leila Kheirandish-Gozal
Pediatric OSA is associated with cognitive risk. Since adult OSA manifests MRI evidence of brain injury, and animal models lead to regional neuronal losses, pediatric OSA patients may also be affected. We assessed the presence of neuronal injury, measured as regional grey matter volume, in 16 OSA children (8 male, 8.1 ± 2.2 years, AHI:11.1 ± 5.9 events/hr), and 200 control subjects (84 male, 8.2 ± 2.0 years), 191 of whom were from the NIH-Pediatric MRI database. High resolution T1-weighted whole-brain images were assessed between groups with voxel-based morphometry, using ANCOVA (covariates, age and gender; family-wise error correction, P < 0...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28290743/brain-anatomy-of-symptom-stratification-in-schizophrenia-a-voxel-based-morphometry-study
#7
Giuseppe Delvecchio, Alessandra Lorandi, Cinzia Perlini, Marco Barillari, Mirella Ruggeri, A Carlo Altamura, Marcella Bellani, Paolo Brambilla
BACKGROUND: Although some Magnetic Resonance Imaging (MRI) studies have investigated the relationship between clinical severity and neuroanatomical alterations in patients with schizophrenia (SCZ), the biological signature associated with illness severity in schizophrenia is still uncertain. Therefore, this study aims to investigate structural brain abnormalities in SCZ, with particular regards to the identification of potential deficits associated with the severity of illness. METHODS: In total, 1...
March 14, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28290386/imaging-biomarker-correlates-with-oxidative-stress-in-parkinson-s-disease
#8
Rajini M Naduthota, Rose D Bharath, Ketan Jhunjhunwala, Ravi Yadav, Jitender Saini, Rita Christopher, Pramod Kumar Pal
BACKGROUND: While oxidative stress (OS) may be one of the crucial factors determining the initiation and progression of Parkinson's disease (PD), its correlation with gray matter (GM) atrophy is not known. AIMS: To determine the GM volume (GMV) changes using voxel-based morphometry (VBM) and correlation with OS marker serum malondialdehyde (MDA) in PD. MATERIALS AND METHODS: Seventy-two patients with PD were clinically evaluated and underwent magnetic resonance imaging (MRI) on a 3T MRI scanner using a 32-channel head coil...
March 2017: Neurology India
https://www.readbyqxmd.com/read/28289601/3d-scattering-transforms-for-disease-classification-in-neuroimaging
#9
Tameem Adel, Taco Cohen, Matthan Caan, Max Welling
Classifying neurodegenerative brain diseases in MRI aims at correctly assigning discrete labels to MRI scans. Such labels usually refer to a diagnostic decision a learner infers based on what it has learned from a training sample of MRI scans. Classification from MRI voxels separately typically does not provide independent evidence towards or against a class; the information relevant for classification is only present in the form of complicated multivariate patterns (or "features"). Deep learning solves this problem by learning a sequence of non-linear transformations that result in feature representations that are better suited to classification...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28287194/-modifiche-morfo-volumetriche-dopo-trattamento-emdr-in-pazienti-drug-na%C3%A3-ve-affetti-da-dpts
#10
Letizia Bossini, Emiliano Santarnecchi, Ilaria Casolaro, Despoina Koukouna, Claudia Caterini, Federica Cecchini, Valentina Fortini, Giampaolo Vatti, Daniela Marino, Isabel Fernandez, Alessandro Rossi, Andrea Fagiolini
RIASSUNTO. Introduzione. Esistono pochi studi che hanno indagato gli effetti di una psicoterapia ritenuta efficace sulle alterazioni strutturali delle regioni cerebrali associate al disturbo da stress post-traumatico (PTSD). Ci siamo, pertanto, proposti di valutare gli effetti neurobiologici della terapia EMDR su un gruppo di 19 pazienti con PTSD, senza cura farmacologica e senza alcuna comorbidità con altri disturbi psichiatrici, a confronto con un gruppo di controllo costituito da 19 soggetti sani non trattati...
January 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/28248867/structural-and-functional-brain-changes-in-early-and-mid-stage-primary-open-angle-glaucoma-using-voxel-based-morphometry-and-functional-magnetic-resonance-imaging
#11
Ming-Ming Jiang, Qing Zhou, Xiao-Yong Liu, Chang-Zheng Shi, Jian Chen, Xiang-He Huang
To investigate structural and functional brain changes in patients with primary open-angle glaucoma (POAG) by using voxel-based morphometry based on diffeomorphic anatomical registration through exponentiated Lie algebra (VBM-DARTEL) and blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI), respectively.Thirteen patients diagnosed with POAG and 13 age- and sex-matched healthy controls were enrolled in the study. For each participant, high-resolution structural brain imaging and blood flow imaging were acquired on a 3...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28239524/pattern-of-gray-matter-volumes-related-to-retinal-thickness-and-its-association-with-cognitive-function-in-relapsing-remitting-ms
#12
Jan-Patrick Stellmann, Hanife Cetin, Kim Lea Young, Sibylle Hodecker, Jana Pöttgen, Diana Bittersohl, Andrea Hassenstein, Timm Oberwahrenbrock, Christoph Heesen, Susanne Siemonsen
BACKGROUND: Neurodegeneration in multiple sclerosis (MS) may be investigated in the visual system as optical coherence tomography (OCT) and magnetic resonance imaging (MRI) allows examining structural integrity in detail. The association between thickness of retinal layers and focal cortical volumes beyond the primary visual system has not been thoroughly investigated. OBJECTIVE: To investigate the association between focal cortical volume and thickness of retinal layers...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28231635/in-vivo-structural-imaging-in-rats-reveals-neuroanatomical-correlates-of-behavioral-sub-dimensions-of-cocaine-addiction
#13
Nazzareno Cannella, Alejandro Cosa-Linan, Elena Büchler, Claudia Falfan-Melgoza, Wolfgang Weber-Fahr, Rainer Spanagel
Cocaine addiction is a multi-dimensional behavioral disorder characterized by a loss of control over cocaine taking despite of detrimental consequences. Structural MRI studies have revealed association between cocaine consumption and gray matter volume (GMV) in cocaine-addicted patients. However, the behavioral correlates of GMV in cocaine addiction are poorly understood. Here, we used a DSM-IV-based rat model of cocaine addiction with high face validity for structural imaging. According to three behavioral sub-dimensions of addiction, rats were separated into two groups showing either addict-like or non-addict-like behavior...
February 23, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28229040/predicting-primary-progressive-aphasias-with-support-vector-machine-approaches-in-structural-mri-data
#14
Sandrine Bisenius, Karsten Mueller, Janine Diehl-Schmid, Klaus Fassbender, Timo Grimmer, Frank Jessen, Jan Kassubek, Johannes Kornhuber, Bernhard Landwehrmeyer, Albert Ludolph, Anja Schneider, Sarah Anderl-Straub, Katharina Stuke, Adrian Danek, Markus Otto, Matthias L Schroeter
Primary progressive aphasia (PPA) encompasses the three subtypes nonfluent/agrammatic variant PPA, semantic variant PPA, and the logopenic variant PPA, which are characterized by distinct patterns of language difficulties and regional brain atrophy. To validate the potential of structural magnetic resonance imaging data for early individual diagnosis, we used support vector machine classification on grey matter density maps obtained by voxel-based morphometry analysis to discriminate PPA subtypes (44 patients: 16 nonfluent/agrammatic variant PPA, 17 semantic variant PPA, 11 logopenic variant PPA) from 20 healthy controls (matched for sample size, age, and gender) in the cohort of the multi-center study of the German consortium for frontotemporal lobar degeneration...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28197123/altered-regional-gray-matter-volume-in-obese-men-a-structural-mri-study
#15
Bin Zhang, Xiao Tian, Derun Tian, Jinhong Wang, Qiming Wang, Chunshui Yu, Chunbo Li, Jijun Wang
Obesity is associated with a number of health problems, especial insulin resistance and Type 2 diabetes. Our previous study showed that obese males had decreased neural activity in the orbital frontal cortex (OFC) and increased activity in the left putamen (Zhang et al., 2015b), which could indicate altered eating behaviors in obesity related to a hyper-functioning striatum and hypo-functioning inhibitory control. Accordingly, our goal of the current study was to determine whether there are alterations in the brain structures within these two neural systems in obese individuals...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28194282/localizing-age-related-changes-in-brain-structure-using-voxel-based-morphometry
#16
Shu Hua Mu, Min Xu, Jun Xiu Duan, Jian Zhang, Li Hai Tan
Aim. We report the dynamic anatomical sequence of human cortical gray matter development from late childhood to young adults using VBM and ROI-based methods. Method. The structural MRI of 91 normal individuals ranging in age from 6 to 26 years was obtained and the GMV for each region was measured. Results. Our results showed that the earliest loss of GMV occurred in left olfactory, right precuneus, caudate, left putamen, pallidum, and left middle temporal gyrus. In addition, the trajectory of maturational and aging showed a linear decline in GMV on both cortical lobes and subcortical regions...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28188918/evaluation-of-multimodal-segmentation-based-on-3d-t1-t2-and-flair-weighted-images-the-difficulty-of-choosing
#17
Tobias Lindig, Raviteja Kotikalapudi, Daniel Schweikardt, Pascal Martin, Friedemann Bender, Uwe Klose, Ulrike Ernemann, Niels K Focke, Benjamin Bender
Voxel-based morphometry is still mainly based on T1-weighted MRI scans. Misclassification of vessels and dura mater as gray matter has been previously reported. Goal of the present work was to evaluate the effect of multimodal segmentation methods available in SPM12, and their influence on identification of age related atrophy and lesion detection in epilepsy patients. 3D T1-, T2- and FLAIR-images of 77 healthy adults (mean age 35.8 years, 19-66 years, 45 females), 7 patients with malformation of cortical development (MCD) (mean age 28...
February 7, 2017: NeuroImage
https://www.readbyqxmd.com/read/28188846/sexual-differentiation-of-the-adolescent-rat-brain-a-longitudinal-voxel-based-morphometry-study
#18
Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima
The sexual differentiation of the rat brain during the adolescent period has been well documented in post-mortem histological studies. However, to further understand the morphological changes occurring in the entire brain, a noninvasive neuroimaging method allowing an unbiased, comprehensive, and longitudinal investigation of brain morphology should be used. In this study, we investigated the sexual differentiation of the rat brain during the adolescent period using longitudinal voxel-based morphometry (VBM) analysis...
March 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28186664/disruption-in-cerebellar-and-basal-ganglia-networks-during-a-visuospatial-task-in-cervical-dystonia
#19
Pavel Filip, Cécile Gallea, Stéphane Lehéricy, Eric Bertasi, Traian Popa, Radek Mareček, Ovidiu V Lungu, Tomáš Kašpárek, Jiří Vaníček, Martin Bareš
BACKGROUND: Although dystonia is traditionally conceptualized as a basal ganglia disorder, increasing interest has been directed at a different neural network node, the cerebellum, which may play a significant role in the pathophysiology of dystonia. Abnormal sensorimotor processing and disturbed motor schemes, possibly attributable to cerebellar changes, remain unclear. METHODS: We sought to characterize the extent of cerebellar dysfunction within the motor network using functional MRI activation analysis, connectivity analysis, and voxel-based morphometry in cervical dystonia patients (n = 25, 15 women, mean age 45...
February 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28184203/prefrontal-parietal-white-matter-volumes-in-healthy-elderlies-are-decreased-in-proportion-to-the-degree-of-cardiovascular-risk-and-related-to-inhibitory-control-deficits
#20
Pedro P Santos, Paula S Da Silveira, Fabio L Souza-Duran, Jaqueline H Tamashiro-Duran, Márcia Scazufca, Paulo R Menezes, Claudia Da Costa Leite, Paulo A Lotufo, Homero Vallada, Maurício Wajngarten, Tânia C De Toledo Ferraz Alves, Patricia Rzezak, Geraldo F Busatto
Cardiovascular risk (CVR) factors may be associated with poor cognitive functioning in elderlies and impairments in brain structure. Using MRI and voxel-based morphometry (VBM), we assessed regional white matter (WM) volumes in a population-based sample of individuals aged 65-75 years (n = 156), subdivided in three CVR subgroups using the Framingham Risk Score. Cognition was assessed using the Short Cognitive Performance Test. In high-risk subjects, we detected significantly reduced WM volume in the right juxtacortical dorsolateral prefrontal region compared to both low and intermediate CVR subgroups...
2017: Frontiers in Psychology
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