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VBM MRI

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https://www.readbyqxmd.com/read/28332625/brain-anatomy-alterations-associated-with-social-networking-site-sns-addiction
#1
Qinghua He, Ofir Turel, Antoine Bechara
This study relies on knowledge regarding the neuroplasticity of dual-system components that govern addiction and excessive behavior and suggests that alterations in the grey matter volumes, i.e., brain morphology, of specific regions of interest are associated with technology-related addictions. Using voxel based morphometry (VBM) applied to structural Magnetic Resonance Imaging (MRI) scans of twenty social network site (SNS) users with varying degrees of SNS addiction, we show that SNS addiction is associated with a presumably more efficient impulsive brain system, manifested through reduced grey matter volumes in the amygdala bilaterally (but not with structural differences in the Nucleus Accumbens)...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28326008/disease-specific-regions-outperform-whole-brain-approaches-in-identifying-progressive-supranuclear-palsy-a-multicentric-mri-study
#2
Karsten Mueller, Robert Jech, Cecilia Bonnet, Jaroslav Tintěra, Jaromir Hanuška, Harald E Möller, Klaus Fassbender, Albert Ludolph, Jan Kassubek, Markus Otto, Evžen Růžička, Matthias L Schroeter
To identify progressive supranuclear palsy (PSP), we combined voxel-based morphometry (VBM) and support vector machine (SVM) classification using disease-specific features in multicentric magnetic resonance imaging (MRI) data. Structural brain differences were investigated at four centers between 20 patients with PSP and 20 age-matched healthy controls with T1-weighted MRI at 3T. To pave the way for future application in personalized medicine, we applied SVM classification to identify PSP on an individual level besides group analyses based on VBM...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28321185/sex-matters-hippocampal-volume-predicts-individual-differences-in-associative-memory-in-cognitively-normal-older-women-but-not-men
#3
Zhiwei Zheng, Rui Li, Fengqiu Xiao, Rongqiao He, Shouzi Zhang, Juan Li
The hippocampus plays a prominent role in associative memory by supporting relational binding and recollection processes. Structural atrophy in the hippocampus is likely to induce associative memory deficits in older adults. Previous studies have primarily focused on average age-related differences in hippocampal structure and memory performance. To date, however, it remains unclear whether individual differences in hippocampal morphometry underlie differential associative memory performance, and whether there are sex differences in the structural correlates of associative memory in healthy older adults...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28319687/effects-of-subclinical-depression-anxiety-and-somatization-on-brain-structure-in-healthy-subjects
#4
Bianca Besteher, Christian Gaser, Kerstin Langbein, Maren Dietzek, Heinrich Sauer, Igor Nenadić
BACKGROUND: Dimensional approaches in highly prevalent psychiatric disorders like depression or anxiety could lead to a better understanding of pathogenesis and advantages in early detection and prevention. In an effort to better understand associations of brain structural variation across the depression/anxiety spectra, we investigated minor subclinical symptoms in a non-clinical healthy population. METHODS: We studied 177 healthy subjects from the community, who underwent high-resolution T1-weighted 3T MRI and completed the symptom-checklist-90 (SCL-90-R)...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28290386/imaging-biomarker-correlates-with-oxidative-stress-in-parkinson-s-disease
#5
Rajini M Naduthota, Rose D Bharath, Ketan Jhunjhunwala, Ravi Yadav, Jitender Saini, Rita Christopher, Pramod Kumar Pal
BACKGROUND: While oxidative stress (OS) may be one of the crucial factors determining the initiation and progression of Parkinson's disease (PD), its correlation with gray matter (GM) atrophy is not known. AIMS: To determine the GM volume (GMV) changes using voxel-based morphometry (VBM) and correlation with OS marker serum malondialdehyde (MDA) in PD. MATERIALS AND METHODS: Seventy-two patients with PD were clinically evaluated and underwent magnetic resonance imaging (MRI) on a 3T MRI scanner using a 32-channel head coil...
March 2017: Neurology India
https://www.readbyqxmd.com/read/28248867/structural-and-functional-brain-changes-in-early-and-mid-stage-primary-open-angle-glaucoma-using-voxel-based-morphometry-and-functional-magnetic-resonance-imaging
#6
Ming-Ming Jiang, Qing Zhou, Xiao-Yong Liu, Chang-Zheng Shi, Jian Chen, Xiang-He Huang
To investigate structural and functional brain changes in patients with primary open-angle glaucoma (POAG) by using voxel-based morphometry based on diffeomorphic anatomical registration through exponentiated Lie algebra (VBM-DARTEL) and blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI), respectively.Thirteen patients diagnosed with POAG and 13 age- and sex-matched healthy controls were enrolled in the study. For each participant, high-resolution structural brain imaging and blood flow imaging were acquired on a 3...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28239524/pattern-of-gray-matter-volumes-related-to-retinal-thickness-and-its-association-with-cognitive-function-in-relapsing-remitting-ms
#7
Jan-Patrick Stellmann, Hanife Cetin, Kim Lea Young, Sibylle Hodecker, Jana Pöttgen, Diana Bittersohl, Andrea Hassenstein, Timm Oberwahrenbrock, Christoph Heesen, Susanne Siemonsen
BACKGROUND: Neurodegeneration in multiple sclerosis (MS) may be investigated in the visual system as optical coherence tomography (OCT) and magnetic resonance imaging (MRI) allows examining structural integrity in detail. The association between thickness of retinal layers and focal cortical volumes beyond the primary visual system has not been thoroughly investigated. OBJECTIVE: To investigate the association between focal cortical volume and thickness of retinal layers...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28197123/altered-regional-gray-matter-volume-in-obese-men-a-structural-mri-study
#8
Bin Zhang, Xiao Tian, Derun Tian, Jinhong Wang, Qiming Wang, Chunshui Yu, Chunbo Li, Jijun Wang
Obesity is associated with a number of health problems, especial insulin resistance and Type 2 diabetes. Our previous study showed that obese males had decreased neural activity in the orbital frontal cortex (OFC) and increased activity in the left putamen (Zhang et al., 2015b), which could indicate altered eating behaviors in obesity related to a hyper-functioning striatum and hypo-functioning inhibitory control. Accordingly, our goal of the current study was to determine whether there are alterations in the brain structures within these two neural systems in obese individuals...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28194282/localizing-age-related-changes-in-brain-structure-using-voxel-based-morphometry
#9
Shu Hua Mu, Min Xu, Jun Xiu Duan, Jian Zhang, Li Hai Tan
Aim. We report the dynamic anatomical sequence of human cortical gray matter development from late childhood to young adults using VBM and ROI-based methods. Method. The structural MRI of 91 normal individuals ranging in age from 6 to 26 years was obtained and the GMV for each region was measured. Results. Our results showed that the earliest loss of GMV occurred in left olfactory, right precuneus, caudate, left putamen, pallidum, and left middle temporal gyrus. In addition, the trajectory of maturational and aging showed a linear decline in GMV on both cortical lobes and subcortical regions...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28188918/evaluation-of-multimodal-segmentation-based-on-3d-t1-t2-and-flair-weighted-images-the-difficulty-of-choosing
#10
Tobias Lindig, Raviteja Kotikalapudi, Daniel Schweikardt, Pascal Martin, Friedemann Bender, Uwe Klose, Ulrike Ernemann, Niels K Focke, Benjamin Bender
Voxel-based morphometry is still mainly based on T1-weighted MRI scans. Misclassification of vessels and dura mater as gray matter has been previously reported. Goal of the present work was to evaluate the effect of multimodal segmentation methods available in SPM12, and their influence on identification of age related atrophy and lesion detection in epilepsy patients. 3D T1-, T2- and FLAIR-images of 77 healthy adults (mean age 35.8 years, 19-66 years, 45 females), 7 patients with malformation of cortical development (MCD) (mean age 28...
February 7, 2017: NeuroImage
https://www.readbyqxmd.com/read/28188846/sexual-differentiation-of-the-adolescent-rat-brain-a-longitudinal-voxel-based-morphometry-study
#11
Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima
The sexual differentiation of the rat brain during the adolescent period has been well documented in post-mortem histological studies. However, to further understand the morphological changes occurring in the entire brain, a noninvasive neuroimaging method allowing an unbiased, comprehensive, and longitudinal investigation of brain morphology should be used. In this study, we investigated the sexual differentiation of the rat brain during the adolescent period using longitudinal voxel-based morphometry (VBM) analysis...
March 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28184203/prefrontal-parietal-white-matter-volumes-in-healthy-elderlies-are-decreased-in-proportion-to-the-degree-of-cardiovascular-risk-and-related-to-inhibitory-control-deficits
#12
Pedro P Santos, Paula S Da Silveira, Fabio L Souza-Duran, Jaqueline H Tamashiro-Duran, Márcia Scazufca, Paulo R Menezes, Claudia Da Costa Leite, Paulo A Lotufo, Homero Vallada, Maurício Wajngarten, Tânia C De Toledo Ferraz Alves, Patricia Rzezak, Geraldo F Busatto
Cardiovascular risk (CVR) factors may be associated with poor cognitive functioning in elderlies and impairments in brain structure. Using MRI and voxel-based morphometry (VBM), we assessed regional white matter (WM) volumes in a population-based sample of individuals aged 65-75 years (n = 156), subdivided in three CVR subgroups using the Framingham Risk Score. Cognition was assessed using the Short Cognitive Performance Test. In high-risk subjects, we detected significantly reduced WM volume in the right juxtacortical dorsolateral prefrontal region compared to both low and intermediate CVR subgroups...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28176504/morphological-and-microstructural-changes-of-the-hippocampus-in-early-mci-a-study-utilizing-the-alzheimer-s-disease-neuroimaging-initiative-database
#13
Peter Lee, Hojin Ryoo, Jinah Park, Yong Jeong
BACKGROUND AND PURPOSE: With the aim of facilitating the early detection of Alzheimer's disease, the Alzheimer's Disease Neuroimaging Initiative proposed two stages based on the memory performance: early mild cognitive impairment (EMCI) and late mild cognitive impairment (LMCI). The current study was designed to investigate structural differences in terms of surface atrophy and microstructural changes of the hippocampus in EMCI and LMCI. METHODS: Hippocampal shape modeling based on progressive template surface deformation was performed on T1-weighted MRI images obtained from 20 cognitive normal (CN) subjects, 17 EMCI patients, and 20 LMCI patients...
January 25, 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28142027/the-right-angular-gyrus-controls-spontaneous-eyeblink-rate-a-combined-structural-mri-and-tms-study
#14
Tamami Nakano
Spontaneous eyeblink rates vary greatly between people, from several to a few dozen blinks per minute. Nevertheless, it remains unknown which brain region controls generation of spontaneous eyeblinks. To investigate this issue, the present study examined brain anatomy, which reflects inter-individual variability in eyeblink rate using structural magnetic resonance images with voxel-based morphometry (VBM) in 57 participants. The gray matter volume of the right angular gyrus (rAG) was positively associated with an increased eyeblink rate...
March 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28126056/alterations-of-gray-and-white-matter-morphology-in-obsessive-compulsive-disorder
#15
Oscar F Gonçalves, Sonia Sousa, Sandra Carvalho, Jorge Leite, Ana Ganho, Ana Fernandes-Gonçalves, Fernando Pocinho, Angel Carracedo, Adriana Sampaio
BACKGROUND: While the ethio-pathogenesis of Obsessive-Compulsive disorder (OCD) remains unknown, there is increased evidence of widespread structural alterations in both white and gray matter in OCD patients that include, but are not restricted, to abnormalities in cortico-striatal-thalamo-cortical (CSTC) regions. The objective of this study was to test the existence of structural alterations in both white and gray matter in a sample of OCD patients when compared with a group of non-clinical matched controls (NCC), using voxel-based morphometry (VBM)...
2017: Psicothema
https://www.readbyqxmd.com/read/28109978/structural-brain-alteration-in-survivors-of-acute-lymphoblastic-leukemia-with-chemotherapy-treatment-a-voxel-based-morphometry-and-diffusion-tensor-imaging-study
#16
Liwei Zou, Lianzi Su, Jiajia Xu, Li Xiang, Longsheng Wang, Zhimin Zhai, Suisheng Zheng
OBJECTIVE: To assess structural brain changes in survivors of acute lymphoblastic leukemia (ALL) with chemotherapy treatment by combining voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS). METHODS: 28 ALL patients (mean age: 40.71±8.58 years, years since diagnosis: 7-38) and 20 age-matched control subjects (mean age: 42.95±6.39 years) selected in this study with 3D T1 and diffusion tensor imaging acquired on a 3.0T Siemens MRI scanner. The ALL group had a history of chemotherapy treatment and off-therapy at least for 3 years was enrolled...
January 18, 2017: Brain Research
https://www.readbyqxmd.com/read/28070745/considering-total-intracranial-volume-and-other-nuisance-variables-in-brain-voxel-based-morphometry-in-idiopathic-pd
#17
Samuel Crowley, Haiqing Huang, Jared Tanner, Qing Zhao, Nadine A Schwab, Loren Hizel, Daniel Ramon, Babette Brumback, Mingzhou Ding, Catherine C Price
Voxel-based morphometry (VBM) studies of Parkinson's disease (PD), have yielded mixed results, possibly due to several studies not accounting for common nuisance variables (age, sex, and total intracranial volume [TICV]). TICV is particularly important because there is evidence for larger TICV in PD. We explored the influence of these covariates on VBM by 1) comparing PD patients and controls before adding covariates, after adding age and sex, and after adding age, sex and TICV, and 2) by comparing controls split into large and small TICV before and after controlling for TICV, with age and sex accounted for in both analyses...
January 9, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28047588/su-f-i-20-volumetric-reduction-of-the-corpus-callosum-in-alzheimer-s-disease-and-mild-cognitive-impairment
#18
R Juh, T Suh, J Han, C Kim, C Oh
PURPOSE: This study investigated correlations between regional corpus callosum (CC) atrophy and cognitive measurements in AD subjects at mild disease stages with volumetry. Our aims were to replicate ROI-based findings of reduced volumes of the CC in mild cognitive impairment (MCI) patients relative to AD and to investigate, on a voxel-by-voxel basis, the presence of significant correlations between CC atrophy and cognitive test scores in AD subjects. METHODS: We used the VBM and cross-sectional ROI-based volumetry approach to conduct a detailed assessment of CC volumetric reductions in a probable AD patient (n=40) in comparison to MCI (n=40) and Subjective memory impairment (SMI) (n=12) matched for age...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28035997/contribution-of-gray-and-white-matter-abnormalities-to-cognitive-impairment-in-multiple-sclerosis
#19
Xiaofei Zhang, Fangfang Zhang, Dehui Huang, Lei Wu, Lin Ma, Hua Liu, Yujun Zhao, Shengyuan Yu, Jiong Shi
Patients with multiple sclerosis (MS) commonly exhibit cognitive impairments (CI). However, the neural mechanisms underlying CI remain unclear. The current study applied diffusion tensor imaging (DTI) and voxel-based morphometric (VBM) magnetic resonance imaging (MRI) techniques to evaluate differences in white matter (WM) integrity and gray matter (GM) volume between MS patients with CI and MS patients with cognitive preservation (CP). Neuropsychological assessment and MRI were obtained from 39 relapsing-remitting MS (RRMS) patients and 29 healthy controls (HCs)...
December 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28018194/cross-sectional-and-longitudinal-relationships-between-depressive-symptoms-and-brain-atrophy-in-ms-patients
#20
Heiner Stuke, Katrin Hanken, Jochen Hirsch, Jan Klein, Fabian Wittig, Andreas Kastrup, Helmut Hildebrandt
Introduction: Depressive symptoms are a frequent and distressing phenomenon in Multiple Sclerosis (MS) patients. Cross-sectional research links these symptoms to reduced brain gray matter volumes in parts of the prefrontal and temporal lobe as well as subcortical structures like the hippocampus, nucleus caudatus and globus pallidus. Nevertheless, prospective relationships between regional gray matter volume and the course of depressive symptoms are poorly understood. Methods: Forty-four patients with relapsing-remitting or secondary progressive MS participated in a prospective study with two assessments of depressive symptoms and high-resolution MRI with an inter-test-interval of 17 months...
2016: Frontiers in Human Neuroscience
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