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VBM MRI

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https://www.readbyqxmd.com/read/29614645/structural-anatomical-investigation-of-long-term-memory-deficit-in-behavioral-frontotemporal-dementia
#1
Maxime Bertoux, Emma C Flanagan, Matthew Hobbs, Amparo Ruiz-Tagle, Carolina Delgado, Marcelo Miranda, Agustín Ibáñez, Andrea Slachevsky, Michael Hornberger
Although a growing body of work has shown that behavioral variant frontotemporal dementia (bvFTD) could present with severe amnesia in approximately half of cases, memory assessment is currently the clinical standard to distinguish bvFTD from Alzheimer's disease (AD). Thus, the concept of "relatively preserved episodic memory" in bvFTD remains the basis of its clinical distinction from AD and a criterion for bvFTD's diagnosis. This view is supported by the idea that bvFTD is not characterized by genuine amnesia and hippocampal degeneration, by contrast to AD...
March 24, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29606954/automatic-mri-quantifying-methods-in-behavioral-variant-frontotemporal-dementia-diagnosis
#2
Antti Cajanus, Anette Hall, Juha Koikkalainen, Eino Solje, Antti Tolonen, Timo Urhemaa, Yawu Liu, Ramona M Haanpää, Päivi Hartikainen, Seppo Helisalmi, Ville Korhonen, Daniel Rueckert, Steen Hasselbalch, Gunhild Waldemar, Patrizia Mecocci, Ritva Vanninen, Mark van Gils, Hilkka Soininen, Jyrki Lötjönen, Anne M Remes
Aims: We assessed the value of automated MRI quantification methods in the differential diagnosis of behavioral-variant frontotemporal dementia (bvFTD) from Alzheimer disease (AD), Lewy body dementia (LBD), and subjective memory complaints (SMC). We also examined the role of the C9ORF72 -related genetic status in the differentiation sensitivity. Methods: The MRI scans of 50 patients with bvFTD (17 C9ORF72 expansion carriers) were analyzed using 6 quantification methods as follows: voxel-based morphometry (VBM), tensor-based morphometry, volumetry (VOL), manifold learning, grading, and white-matter hyperintensities...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29600478/abnormal-brain-structure-as-a-potential-biomarker-for-venous-erectile-dysfunction-evidence-from-multimodal-mri-and-machine-learning
#3
Lingli Li, Wenliang Fan, Jun Li, Quanlin Li, Jin Wang, Yang Fan, Tianhe Ye, Jialun Guo, Sen Li, Youpeng Zhang, Yongbiao Cheng, Yong Tang, Hanqing Zeng, Lian Yang, Zhaohui Zhu
OBJECTIVES: To investigate the cerebral structural changes related to venous erectile dysfunction (VED) and the relationship of these changes to clinical symptoms and disorder duration and distinguish patients with VED from healthy controls using a machine learning classification. METHODS: 45 VED patients and 50 healthy controls were included. Voxel-based morphometry (VBM), tract-based spatial statistics (TBSS) and correlation analyses of VED patients and clinical variables were performed...
March 29, 2018: European Radiology
https://www.readbyqxmd.com/read/29593488/a-set-of-functional-brain-networks-for-the-comprehensive-evaluation-of-human-characteristics
#4
Yul-Wan Sung, Yousuke Kawachi, Uk-Su Choi, Daehun Kang, Chihiro Abe, Yuki Otomo, Seiji Ogawa
Many human characteristics must be evaluated to comprehensively understand an individual, and measurements of the corresponding cognition/behavior are required. Brain imaging by functional MRI (fMRI) has been widely used to examine brain function related to human cognition/behavior. However, few aspects of cognition/behavior of individuals or experimental groups can be examined through task-based fMRI. Recently, resting state fMRI (rs-fMRI) signals have been shown to represent functional infrastructure in the brain that is highly involved in processing information related to cognition/behavior...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29578488/risk-factors-associated-with-cortical-thickness-and-white-matter-hyperintensities-in-dementia-free-okinawan-elderly
#5
Lisa C Silbert, David Lahna, Nutta-On Promjunyakul, Erin Boespflug, Yusuke Ohya, Yasushi Higashiuesato, Junko Nishihira, Yuriko Katsumata, Takashi Tokashiki, Hiroko Dodge
BACKGROUND: Cortical gray matter (GM) and white matter (WM) deterioration are signals of neurodegeneration and increased dementia risk; however, their specific etiologies in dementia-free aging is unclear. OBJECTIVE: The objective of this study was to examine potentially modifiable risk factors of GM and WM degeneration in a well-characterized cohort of dementia-free elderly. METHODS: 96 Okinawan elderly participants (age 83.6) from the Keys to Optimal Cognitive Aging Project (KOCOA) underwent MRI and cognitive evaluation...
March 23, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29481315/grey-matter-correlates-of-autistic-traits-in-women-with-anorexia-nervosa
#6
Malin Björnsdotter, Monika Davidovic, Louise Karjalainen, Göran Starck, Håkan Olausson, Elisabet Wentz
BACKGROUND: Patients with anorexia nervosa exhibit higher levels of behaviours typically associated with autism-spectrum disorder (ASD), but the neural basis is unclear. We sought to determine whether elevated autistic traits in women with anorexia nervosa may be reflected in cortical morphology. METHODS: We used voxel-based morphometry (VBM) to examine regional grey matter volumes in high-resolution MRI structural brain scans in women with anorexia nervosa and matched healthy controls...
March 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29480170/reduced-gray-matter-volume-of-the-thalamus-and-hippocampal-region-in-elderly-healthy-adults-with-no-impact-of-apoe-%C3%A9-4-a-longitudinal-voxel-based-morphometry-study
#7
Paula Squarzoni, Fabio Luis Souza Duran, Geraldo F Busatto, Tania Correa Toledo de Ferraz Alves
BACKGROUND: Many cross-sectional voxel-based morphometry (VBM) investigations have shown significant inverse correlations between chronological age and gray matter (GM) volume in several brain regions in healthy humans. However, few VBM studies have documented GM decrements in the healthy elderly with repeated MRI measurements obtained in the same subjects. Also, the extent to which the APOE ɛ4 allele influences longitudinal findings of GM reduction in the healthy elderly is unclear...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29441669/hiv-ageing-cognition-and-neuroimaging-at-4-year-follow-up
#8
B I Haynes, M Pitkanen, R Kulasegaram, S J Casey, M Schutte, K Towgood, B Peters, G J Barker, M D Kopelman
OBJECTIVES: The aim of the study was to investigate the hypothesis of accelerated cognitive ageing in HIV-positive individuals using longitudinal assessment of cognitive performance and quantitative magnetic resonance imaging (MRI). METHODS: We assessed a broad cognitive battery and quantitative MRI metrics [voxel-based morphometry (VBM) and diffusion tensor imaging (DTI)] in asymptomatic HIV-positive men who have sex with men (15 aged 20-40 years and 15 aged ≥ 50 years), and HIV-seronegative matched controls (nine aged 20-40 years and 16 aged ≥ 50 years)...
February 14, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29423004/herpes-zoster-chronification-to-postherpetic-neuralgia-induces-brain-activity-and-grey-matter-volume-change
#9
Song Cao, Bangyong Qin, Yi Zhang, Jie Yuan, Bao Fu, Peng Xie, Ganjun Song, Ying Li, Tian Yu
OBJECTIVE: Herpes zoster (HZ) can develop into postherpetic neuralgia (PHN), which is a chronic neuropathic pain (NP). Whether the chronification from HZ to PHN induced brain functional or structural change is unknown and no study compared the changes of the same brains of patients who transited from HZ to PHN. We minimized individual differences and observed whether the chronification of HZ to PHN induces functional and pain duration dependent grey matter volume (GMV) change in HZ-PHN patients...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29410079/the-marburg-m%C3%A3-nster-affective-disorders-cohort-study-macs-a-quality-assurance-protocol-for-mr-neuroimaging-data
#10
Christoph Vogelbacher, Thomas W D Möbius, Jens Sommer, Verena Schuster, Udo Dannlowski, Tilo Kircher, Astrid Dempfle, Andreas Jansen, Miriam H A Bopp
Large, longitudinal, multi-center MR neuroimaging studies require comprehensive quality assurance (QA) protocols for assessing the general quality of the compiled data, indicating potential malfunctions in the scanning equipment, and evaluating inter-site differences that need to be accounted for in subsequent analyses. We describe the implementation of a QA protocol for functional magnet resonance imaging (fMRI) data based on the regular measurement of an MRI phantom and an extensive variety of currently published QA statistics...
January 31, 2018: NeuroImage
https://www.readbyqxmd.com/read/29400417/brain-structure-differences-between-chinese-and-caucasian-cohorts-a-comprehensive-morphometry-study
#11
Yuchun Tang, Lu Zhao, Yunxia Lou, Yonggang Shi, Rui Fang, Xiangtao Lin, Shuwei Liu, Arthur Toga
Numerous behavioral observations and brain function studies have demonstrated that neurological differences exist between East Asians and Westerners. However, the extent to which these factors relate to differences in brain structure is still not clear. As the basis of brain functions, the anatomical differences in brain structure play a primary and critical role in the origination of functional and behavior differences. To investigate the underlying differences in brain structure between the two cultural/ethnic groups, we conducted a comparative study on education-matched right-handed young male adults (age = 22-29 years) from two cohorts, Han Chinese (n = 45) and Caucasians (n = 45), using high-dimensional structural magnetic resonance imaging (MRI) data...
February 5, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29387529/the-hippocampal-network-model-a-transdiagnostic-metaconnectomic-approach
#12
Eithan Kotkowski, Larry R Price, P Mickle Fox, Thomas J Vanasse, Peter T Fox
Purpose: The hippocampus plays a central role in cognitive and affective processes and is commonly implicated in neurodegenerative diseases. Our study aimed to identify and describe a hippocampal network model (HNM) using trans-diagnostic MRI data from the BrainMap® database. We used meta-analysis to test the network degeneration hypothesis (NDH) (Seeley et al., 2009) by identifying structural and functional covariance in this hippocampal network. Methods: To generate our network model, we used BrainMap's VBM database to perform a region-to-whole-brain (RtWB) meta-analysis of 269 VBM experiments from 165 published studies across a range of 38 psychiatric and neurological diseases reporting hippocampal gray matter density alterations...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29373319/brain-gray-matter-volume-differences-in-obese-youth-with-type-2-diabetes-a-pilot-study
#13
Jacob M Redel, Mark DiFrancesco, Jennifer Vannest, Mekibib Altaye, Dean Beebe, Jane Khoury, Lawrence M Dolan, Gregory Lee, Hermine Brunner, Scott Holland, Cassandra Brady, Amy S Shah
BACKGROUND: Adults with type 2 diabetes (T2D) have significantly lower gray matter volume (GMV) compared to healthy peers. Whether GMV differences exist in youth with T2D remains unclear. Thus, we compared global and regional GMV between obese youth with T2D with age, race and sex similar healthy controls. METHODS: In a cross-sectional study, 20 obese youth with T2D underwent T1-weighted brain magnetic resonance imaging (MRI). Comparisons were made to 20 age, race and sex similar controls...
January 26, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29344423/age-related-gray-and-white-matter-changes-in-normal-adult-brains
#14
Farnaz Farokhian, Chunlan Yang, Iman Beheshti, Hiroshi Matsuda, Shuicai Wu
Normal aging is associated with both structural changes in many brain regions and functional declines in several cognitive domains with advancing age. Advanced neuroimaging techniques enable explorative analyses of structural alterations that can be used as assessments of such age-related changes. Here we used voxel-based morphometry (VBM) to investigate regional and global brain volume differences among four groups of healthy adults from the IXI Dataset: older females (OF, mean age 68.35 yrs; n=69), older males (OM, 68...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29338891/gray-and-white-matter-changes-and-their-relation-to-illness-trajectory-in-first-episode-psychosis
#15
Alejandro Keymer-Gausset, Anna Alonso-Solís, Iluminada Corripio, Rosa B Sauras-Quetcuti, Edith Pomarol-Clotet, Erick J Canales-Rodriguez, Eva Grasa-Bello, Enric Álvarez, Maria J Portella
Previous works have studied structural brain characteristics in first-episode psychosis (FEP), but few have focused on the relation between brain differences and illness trajectories. The aim of this study is to analyze gray and white matter changes in FEP patients and their relation with one-year clinical outcomes. A sample of 41 FEP patients and 41 healthy controls (HC), matched by age and educational level was scanned with a 3T MRI during the first month of illness onset. One year later, patients were assigned to two illness trajectories (schizophrenia and non-schizophrenia)...
March 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29322264/cerebral-gray-matter-volume-in-patients-with-chronic-migraine-correlations-with-clinical-features
#16
Gianluca Coppola, Barbara Petolicchio, Antonio Di Renzo, Emanuele Tinelli, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Anna Ambrosini, Francesca Caramia, Vittorio Di Piero, Francesco Pierelli
BACKGROUND: To date, few MRI studies have been performed in patients affected by chronic migraine (CM), especially in those without medication overuse. Here, we performed magnetic resonance imaging (MRI) voxel-based morphometry (VBM) analyses to investigate the gray matter (GM) volume of the whole brain in patients affected by CM. Our aim was to investigate whether fluctuations in the GM volumes were related to the clinical features of CM. METHODS: Twenty untreated patients with CM without a past medical history of medication overuse underwent 3-Tesla MRI scans and were compared to a group of 20 healthy controls (HCs)...
December 8, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29321625/cerebellar-grey-matter-modifications-in-lower-limb-amputees-not-using-prosthesis
#17
Antonella Di Vita, Maddalena Boccia, Liana Palermo, Federico Nemmi, Marco Traballesi, Stefano Brunelli, Roberto De Giorgi, Gaspare Galati, Cecilia Guariglia
Plastic brain changes following peripheral deafferentation, in particular those following limb amputations, are well-documented, with significant reduction of grey matter (GM) in the sensory-motor cerebral areas representing the amputated limb. However, few studies have investigated the role played by the use of a prosthesis in these structural brain modifications. Here we hypothesized that using a functional prosthesis that allows individuals to perform actions may reduce grey matter reduction. We investigated the brain structural reorganization following lower limb amputation by using a Voxel Based Morphometry (VBM) analysis of structural magnetic resonance imaging (MRI) in 8 right-handed individuals with lower limb amputation (LLA) fitted with prostheses (LLAwp), compared to 6 LLA who had never used a prosthesis (LLAnp)...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29275588/-impairments-of-gray-matter-in-mri-negative-epileptic-patients-with-different-seizure-types
#18
W Quan, Q Xu, F Yang, G H Chen, Z X Lin, Q R Zhang, J H Xiao, G M Lu, Z Q Zhang
Objective: To investigate the damage of gray matter structure in MRI-negative epilepsy patients with different symptoms by voxel-based morphometry (VBM). Methods: From June, 2009 to October, 2016, ninety MRI-negative epilepsy patients and thirty-five healthy volunteers underwent the 3T magnetic resonance imaging scan in Nanjing General Hospital. The patients were divided into three groups, including idiopathic generalized tonic-clonic seizure (I-GTCS), secondarily generalized tonic-clonic seizure (S-GTCS), and partial seizure (PS) according to different symptoms...
December 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29274430/divergent-brain-changes-in-two-audiogenic-rat-strains-a-voxel-based-morphometry-and-diffusion-tensor-imaging-comparison-of-the-genetically-epilepsy-prone-rat-gepr-3-and-the-wistar-audiogenic-rat-war
#19
Yichien Lee, Olga C Rodriguez, Chris Albanese, Victor Rodrigues Santos, José Antônio Cortes de Oliveira, Ana Luiza Ferreira Donatti, Artur Fernandes, Norberto Garcia-Cairasco, Prosper N'Gouemo, Patrick A Forcelli
Acoustically evoked seizures (e.g., audiogenic seizures or AGS) are common in models of inherited epilepsy and occur in a variety of species including rat, mouse, and hamster. Two models that have been particularly well studied are the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR) strains. Acute and repeated AGS, as well as comorbid conditions, displays a close phenotypic overlap in these models. Whether these similarities arise from convergent or divergent structural changes in the brain remains unknown...
March 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29244231/differences-in-regional-grey-matter-volumes-in-currently-ill-patients-with-anorexia-nervosa
#20
Andrea Phillipou, Susan Lee Rossell, Caroline Gurvich, David Jonathan Castle, Larry Allen Abel, Richard Grant Nibbs, Matthew Edward Hughes
Neurobiological findings in anorexia nervosa (AN) are inconsistent, including differences in regional grey matter volumes. Methodological limitations often contribute to the inconsistencies reported. The aim of this study was to improve on these methodologies by utilising voxel-based morphometry (VBM) analysis with the use of diffeomorphic anatomic registration through an exponentiated lie algebra algorithm (DARTEL), in a relatively large group of individuals with AN. Twenty-six individuals with AN and 27 healthy controls underwent a T1-weighted magnetic resonance imaging (MRI) scan...
January 2018: European Journal of Neuroscience
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