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Morphometry MRI

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https://www.readbyqxmd.com/read/29773998/larger-gray-matter-volume-in-the-basal-ganglia-of-heavy-cannabis-users-detected-by-voxel-based-morphometry-and-subcortical-volumetric-analysis
#1
Ana Moreno-Alcázar, Begoña Gonzalvo, Erick J Canales-Rodríguez, Laura Blanco, Diana Bachiller, Anna Romaguera, Gemma C Monté-Rubio, Carlos Roncero, Peter J McKenna, Edith Pomarol-Clotet
Background: Structural imaging studies of cannabis users have found evidence of both cortical and subcortical volume reductions, especially in cannabinoid receptor-rich regions such as the hippocampus and amygdala. However, the findings have not been consistent. In the present study, we examined a sample of adult heavy cannabis users without other substance abuse to determine whether long-term use is associated with brain structural changes, especially in the subcortical regions. Method: We compared the gray matter volume of 14 long-term, heavy cannabis users with non-using controls...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29755611/morphological-biomarker-differentiating-mci-converters-from-nonconverters-longitudinal-evidence-based-on-hemispheric-asymmetry
#2
Xiaojing Long, Chunxiang Jiang, Lijuan Zhang
Identifying subjects with mild cognitive impairment (MCI) who may probably progress to Alzheimer's disease (AD) is important for better understanding the disease mechanisms and facilitating early treatments. In addition to the direct volumetric and thickness measurement based on high-resolution magnetic resonance imaging (MRI), hemispheric asymmetry could be a potential index to detect morphological variations in MCI patients with a high risk of conversion to AD. The present study collected a set of longitudinal MRI data from 53 MCI converters and nonconverters and investigated the asymmetry differences between groups...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/29754151/a-voxel-based-magnetic-resonance-imaging-morphometric-study-of-cerebral-and-cerebellar-gray-matter-in-patients-under-65-years-with-essential-tremor
#3
Hongmei Cao, Rong Wang, Xue Luo, Xianjun Li, Mark Hallett, Johanna Thompson-Westra, Jian Yang, Qiumin Qu, Xiaobo Yang
BACKGROUND The aim of this study was to compare the morphological changes in cerebral and cerebellar gray matter in patients with essential tremor under 60-years-of-age, with age-matched and gender-matched normal healthy volunteer control subjects, using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM) analysis. MATERIAL AND METHODS A retrospective, controlled, comparative clinical study included 17 patients with essential tremor, <60 years-of-age, and 17 age-matched and gender-matched healthy volunteer control subjects, recruited between June 2010-July 2012...
May 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29750339/pre-and-postsurgical-cognitive-trajectories-and-quantitative-mri-changes-in-rasmussen-syndrome
#4
Sarah R Rudebeck, Sara Shavel-Jessop, Sophia Varadkar, Tamsin Owen, J Helen Cross, Faraneh Vargha-Khadem, Torsten Baldeweg
OBJECTIVE: To quantify the longitudinal cognitive trajectory, before and after surgery, of Rasmussen syndrome (RS), a rare disease characterized by focal epilepsy and progressive atrophy of one cerebral hemisphere. METHOD: Thirty-two patients (mean age = 6.7 years; 17 male, 16 left hemispheres affected) were identified from hospital records. The changes in intelligence scores during 2 important phases in the patients' journey to treatment were investigated: (1) during the preoperative period (n = 28, mean follow-up 3...
May 11, 2018: Epilepsia
https://www.readbyqxmd.com/read/29740296/distinguishing-adolescents-with-conduct-disorder-from-typically-developing-youngsters-based-on-pattern-classification-of-brain-structural-mri
#5
Jianing Zhang, Weixiang Liu, Jing Zhang, Qiong Wu, Yidian Gao, Yali Jiang, Junling Gao, Shuqiao Yao, Bingsheng Huang
Background: Conduct disorder (CD) is a mental disorder diagnosed in childhood or adolescence that presents antisocial behaviors, and is associated with structural alterations in brain. However, whether these structural alterations can distinguish CD from healthy controls (HCs) remains unknown. Here, we quantified these structural differences and explored the classification ability of these quantitative features based on machine learning (ML). Materials and Methods: High-resolution 3D structural magnetic resonance imaging (sMRI) was acquired from 60 CD subjects and 60 age-matched HCs...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29734487/cortical-thickness-and-white-matter-integrity-abnormalities-in-obsessive-compulsive-disorder-a-combined-multimodal-surface-based-morphometry-and-tract-based-spatial-statistics-study
#6
Cong Zhou, Jian Xu, Liangliang Ping, Fengrui Zhang, Wei Chen, Zonglin Shen, Linling Jiang, Xiufeng Xu, Yuqi Cheng
BACKGROUND: Cerebral morphological abnormalities may play a key role in pathogenesis of obsessive-compulsive disorder (OCD). However, few studies have used multimodal imaging strategies to investigate alterations of cortical morphometry and white matter (WM) integrity. This study aimed to evaluate cortical thickness, cortical and subcortical volume, and WM integrity characteristics in OCD patients comprehensively. METHODS: We acquired magnetic resonance imaging (MRI) scans from 52 OCD patients and 46 well-matched healthy controls (HCs)...
May 7, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29729010/lung-morphometry-using-hyperpolarized-129-xe-multi-b-diffusion-mri-with-compressed-sensing-in-healthy-subjects-and-patients-with-copd
#7
Huiting Zhang, Junshuai Xie, Sa Xiao, Xiuchao Zhao, Ming Zhang, Lei Shi, Ke Wang, Guangyao Wu, Xianping Sun, Chaohui Ye, Xin Zhou
PURPOSE: To demonstrate the feasibility of compressed sensing (CS) to accelerate the acquisition of hyperpolarized (HP) 129 Xe multi-b diffusion MRI for quantitative assessments of lung microstructural morphometry. METHODS: Six healthy subjects and six chronic obstructive pulmonary disease (COPD) subjects underwent HP 129 Xe multi-b diffusion MRI (b = 0, 10, 20, 30, and 40 s/cm2 ). First, a fully sampled (FS) acquisition of HP 129 Xe multi-b diffusion MRI was conducted in one healthy subject...
May 4, 2018: Medical Physics
https://www.readbyqxmd.com/read/29717787/isotropic-morphometry-and-multicomponent-t-1-%C3%AF-mapping-of-human-knee-articular-cartilage-in-vivo-at-3t
#8
Rahman Baboli, Azadeh Sharafi, Gregory Chang, Ravinder R Regatte
BACKGROUND: The progressive loss of hyaline articular cartilage due to osteoarthritis (OA) changes the functional and biochemical properties of cartilage. Measuring the T1 ρ along with the morphological assessment can potentially be used as noninvasive biomarkers in detecting early-stage OA. To correlate the biochemical and morphological data, submillimeter isotropic resolution for both studies is required. PURPOSE: To implement a high spatial resolution 3D-isotropic-MRI sequence for simultaneous assessment of morphological and biexponential T1 ρ relaxometry of human knee cartilage in vivo...
May 2, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29707531/morphometric-magnetic-resonance-imaging-study-in-children-with-primary-monosymptomatic-nocturnal-enuresis
#9
Mengxing Wang, Anyi Zhang, Jilei Zhang, Haifeng Lu, Shuai Xu, Zhaoxia Qin, Jun Ma, Xiaoxia Du
Objective: Primary monosymptomatic nocturnal enuresis (PMNE) refers to bed-wetting in children who have no other lower urinary tract symptoms and are never dry for more than 6 months. Our previous studies demonstrated that children with PMNE exhibited brain functional abnormalities compared with healthy controls; however, researches on the abnormalities in gray matter were limited. This study aimed to investigate brain structural changes in gray matter of children with PMNE using magnetic resonance imaging (MRI)...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29704671/apathy-in-alzheimer-s-disease-and-frontotemporal-dementia-distinct-clinical-profiles-and-neural-correlates
#10
Fiona Kumfor, Alice Zhen, John R Hodges, Olivier Piguet, Muireann Irish
OBJECTIVE: Apathy is the most prevalent and disabling non-cognitive symptom of dementia and affects 90% of patients across the disease course. Despite its pervasiveness, how apathy manifests across dementia syndromes and the neurobiological mechanisms driving these symptoms are poorly understood. Here, we applied the multidimensional ABC model of apathy, which recognizes Affective, Behavioural and Cognitive apathy, in Alzheimer's disease (AD) and behavioural-variant frontotemporal dementia (bvFTD)...
March 29, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29697762/longitudinal-trajectories-of-brain-volume-and-cortical-thickness-in-treated-and-untreated-primary-hiv-infection
#11
Ryan Sanford, Beau M Ances, Dieter J Meyerhoff, Richard W Price, Dietmar Fuchs, Henrik Zetterberg, Serena Spudich, D Louis Collins
Background: HIV penetrates the brain in early infection. We used neuroimaging to longitudinally examine the impact of HIV and combination antiretroviral therapy (cART) on the brain in treated and untreated HIV-positive participants starting in primary HIV infection (PHI). Methods: Sixty-five participants, enrolled during PHI, underwent longitudinal MRI, 30 of whom commenced cART during follow-up. Cross-sectional data from 16 chronic HIV-infected (CHI) and 19 HIV-negative participants were included for comparison...
April 24, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29696595/delay-discounting-mediates-the-association-between-posterior-insular-cortex-volume-and-social-media-addiction-symptoms
#12
Ofir Turel, Qinghua He, Damien Brevers, Antoine Bechara
Addiction-like symptoms in relation to excessive and compulsive social media use are common in the general population. Because they can lead to various adverse effects, there is a growing need to understand the brain systems and processes that are involved in potential social media addiction. We focus on the morphology of the posterior subdivision of the insular cortex (i.e., the insula), because it has been shown to be instrumental to supporting the maintenance of substance addictions and problematic behaviors...
April 25, 2018: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29695908/the-functional-and-structural-characteristics-of-the-emotion-network-in-alexithymia
#13
Dai Han, Mei Li, Minjun Mei, Xiaofei Sun
Background: Alexithymia is a multifaceted personality trait characterized by emotional dysfunction. Methods: In this study, the functional and structural features of the emotion network in alexithymia were investigated using resting-state functional MRI (rsfMRI), voxel-based morphometry (VBM), functional connectivity (FC) analysis, and diffusion tensor imaging (DTI). Alexithymic and non-alexithymic students were recruited from the local university. The intrinsic neural activity and gray matter density of the brain regions in the emotion network were measured using rsfMRI and VBM; the FC and structural connectivity of the brain regions in the emotion network were measured using FC analysis and DTI...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29691468/large-scale-brain-network-associated-with-creative-insight-combined-voxel-based-morphometry-and-resting-state-functional-connectivity-analyses
#14
Takeshi Ogawa, Takatsugu Aihara, Takeaki Shimokawa, Okito Yamashita
Creative insight occurs with an "Aha!" experience when solving a difficult problem. Here, we investigated large-scale networks associated with insight problem solving. We recruited 232 healthy participants aged 21-69 years old. Participants completed a magnetic resonance imaging study (MRI; structural imaging and a 10 min resting-state functional MRI) and an insight test battery (ITB) consisting of written questionnaires (matchstick arithmetic task, remote associates test, and insight problem solving task)...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29688873/assessing-the-marks-of-change-how-psychotherapy-alters-the-brain-structure-in-women-with-borderline-personality-disorder
#15
Falk Mancke, Ruth Schmitt, Dorina Winter, Inga Niedtfeld, Sabine C Herpertz, Christian Schmahl
BACKGROUND: There is increasing evidence that psychotherapy can alter the function of the brain of patients with borderline personality disorder (BPD). However, it is not known whether psychotherapy can also modify the brain structure of patients with BPD. METHODS: We used structural MRI data of female patients with BPD before and after participation in 12 weeks of residential dialectical behavioural therapy (DBT) and compared them to data from female patients with BPD who received treatment as usual (TAU)...
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29687532/altered-structural-and-functional-connectivity-of-the-insula-in-functional-dyspepsia
#16
P Liu, Y Fan, Y Wei, F Zeng, R Li, N Fei, W Qin
BACKGROUND: Functional dyspepsia (FD) is a common functional gastrointestinal disease. Neuroimaging studies have identified that insula is involved in the pathogenesis of FD. However, less is known about structural and functional connectivity of insula in FD. METHODS: In this study, 67 FD patients and 46 healthy controls (HCs) underwent structural MRI, resting-state functional MRI, diffusion tensor imaging (DTI) scans, and clinical assessment. We used the 3 neuroimaging modalities to investigate structural and functional connectivity of insula between FD patients and HCs, and we examined relationships between the neuroimaging findings and clinical symptoms...
April 23, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29673966/automated-search-of-control-points-in-surface-based-morphometry
#17
Antonietta Canna, Andrea G Russo, Sara Ponticorvo, Renzo Manara, Alessandro Pepino, Mario Sansone, Francesco Di Salle, Fabrizio Esposito
Cortical surface-based morphometry is based on a semi-automated analysis of structural MRI images. In FreeSurfer, a widespread tool for surface-based analyses, a visual check of gray-white matter borders is followed by the manual placement of control points to drive the topological correction (editing) of segmented data. A novel algorithm combining radial sampling and machine learning is presented for the automated control point search (ACPS). Four data sets with 3 T MRI structural images were used for ACPS validation, including raw data acquired twice in 36 healthy subjects and both raw and FreeSurfer preprocessed data of 125 healthy subjects from public databases...
April 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29673867/structural-differences-in-hippocampal-and-entorhinal-gray-matter-volume-support-individual-differences-in-first-person-navigational-ability
#18
Katherine R Sherrill, Elizabeth R Chrastil, Irem Aselcioglu, Michael E Hasselmo, Chantal E Stern
The ability to update position and orientation to reach a goal is crucial to spatial navigation and individuals vary considerably in this ability. The current structural MRI study used voxel-based morphometry (VBM) analysis to relate individual differences in human brain morphology to performance in an active navigation task that relied on updating position and orientation in a landmark-free environment. Goal-directed navigation took place from either a first person perspective, similar to a person walking through the landmark-free environment, or Survey perspective, a bird's eye view...
April 16, 2018: Neuroscience
https://www.readbyqxmd.com/read/29651330/analysis-of-neuroanatomical-differences-in-mice-with-genetically-modified-serotonin-transporters-assessed-by-structural-magnetic-resonance-imaging
#19
Jacob Ellegood, Yohan Yee, Travis M Kerr, Christopher L Muller, Randy D Blakely, R Mark Henkelman, Jeremy Veenstra-VanderWeele, Jason P Lerch
Background: The serotonin (5-HT) system has long been implicated in autism spectrum disorder (ASD) as indicated by elevated whole blood and platelet 5-HT, altered platelet and brain receptor and transporter binding, and genetic linkage and association findings. Based upon work in genetically modified mice, 5-HT is known to influence several aspects of brain development, but systematic neuroimaging studies have not previously been reported. In particular, the 5-HT transporter (serotonin transporter, SERT; 5-HTT) gene, Slc6a4 , has been extensively studied...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29648977/severe-tbi-patients-without-focal-lesion-but-with-behavioral-disorders-shrinkage-of-gray-matter-nuclei-and-thalamus-revealed-in-a-pilot-voxel-based-mri-study
#20
Alexis Ruet, Françoise Joyeux, Shailandra Segobin, Corinne Jokic, Béatrice Desgranges, Francis Eustache, Anne-Lise Pitel
After a traumatic brain injury (TBI), behavioral disorders can occur without major focal brain lesion and in this case, their pathophysiology remains unclear. The aim of this study is to examine whether TBI patients with behavioral disorders but without any focal damage, as observed from an initial clinical CT scan, present subtle volumetric alterations that could be measured voxel-by-voxel in the whole brain with magnetic resonance imaging (MRI). Eight severe TBI male adults with behavioral sequela but without major focal cerebral lesion and 17 age-matched controls underwent a volumetric T1-weighted 1...
March 6, 2018: Journal of Neurotrauma
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