keyword
https://read.qxmd.com/read/38545268/neurometabolism-and-brain-morphometry-in-an-adolescent-female-with-an-extra-hepatic-congenital-portosystemic-shunt
#1
JOURNAL ARTICLE
Isaline Chabbey, Cristina Cudalbu, Eugénie Barras, Sylviane Hanquinet, Bénédicte Maréchal, Anne-Laure Rougemont, Julie Wacker, Florence Zangas-Gheri, Valérie A McLin
BACKGROUND: Chronic hepatic encephalopathy (CHE) has been reported both in patients with congenital porto-systemic shunts (CPSS) and chronic liver disease. CHE is difficult to recognize in children as there is no clear definition and its manifestations are highly variable. CHE is associated with variations in brain volumes and metabolites that have already been demonstrated using 1.5-3T MRI systems. However, the in-depth study of brain metabolism requires the high spectral resolution of high magnetic fields...
February 2024: JPGN reports
https://read.qxmd.com/read/38533783/brain-morphometry-in-former-american-football-players-findings-from-the-diagnose-cte-research-project
#2
JOURNAL ARTICLE
Hector Arciniega, Zachary H Baucom, Fatima Tuz-Zahra, Yorghos Tripodis, Omar John, Holly Carrington, Nicholas Kim, Evdokiya E Knyazhanskaya, Leonard B Jung, Katherine Breedlove, Tim L T Wiegand, Daniel H Daneshvar, R Jarrett Rushmore, Tashrif Billah, Ofer Pasternak, Michael J Coleman, Charles H Adler, Charles Bernick, Laura J Balcer, Michael L Alosco, Inga K Koerte, Alexander P Lin, Jeffrey L Cummings, Eric M Reiman, Robert A Stern, Martha E Shenton, Sylvain Bouix
Exposure to repetitive head impacts (RHIs) in contact sports is associated with neurodegenerative disorders including chronic traumatic encephalopathy (CTE) which currently can be diagnosed only at postmortem. American football players are at higher risk of developing CTE given their exposure to RHIs. One promising approach for diagnosing CTE in vivo is to explore known neuropathological abnormalities at postmortem in living individuals using structural magnetic resonance imaging (MRI). MRI brain morphometry was evaluated in 170 male former American football players ages 45-74 years (n = 114 professional; n = 56 college) and 54 same-age unexposed asymptomatic male controls (n = 58 age range 45-74)...
March 27, 2024: Brain
https://read.qxmd.com/read/38529038/epilepsy-related-functional-brain-network-alterations-are-already-present-at-an-early-age-in-the-gaers-rat-model-of-genetic-absence-epilepsy
#3
JOURNAL ARTICLE
Lydia Wachsmuth, Leo Hebbelmann, Jutta Prade, Laura C Kohnert, Henriette Lambers, Annika Lüttjohann, Thomas Budde, Andreas Hess, Cornelius Faber
INTRODUCTION: Genetic Absence Epilepsy Rats from Strasbourg (GAERS) represent a model of genetic generalized epilepsy. The present longitudinal study in GAERS and age-matched non-epileptic controls (NEC) aimed to characterize the epileptic brain network using two functional measures, resting state-functional magnetic resonance imaging (rs-fMRI) and manganese-enhanced MRI (MEMRI) combined with morphometry, and to investigate potential brain network alterations, following long-term seizure activity...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38522767/pain-relief-related-structural-brain-alterations-in-trigeminal-neuralgia-induced-by-non-invasive-stereotactic-radiosurgery-a-pilot-study
#4
JOURNAL ARTICLE
Jonas Kolodziej, Bogdan Pintea, Jan Patrick Boström, Burkhard Pleger
PURPOSE: Trigeminal neuralgia (TN) is a devastating chronic pain disorder, defined by unilateral shock like pain in at least one division of the trigeminal nerve. Although several studies have investigated structural brain plasticity in TN patients, treatment-induced alterations remain largely uninvestigated. MATERIALS/METHODS: Combining T1-weighted magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) and multiple-regression analyses, we assessed gray matter maps of TN patients to investigate changes in gray matter volume (GMV) from before to half a year after stereotactic radiosurgery (SRS)...
March 22, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38517798/assessment-of-perivascular-space-morphometry-across-the-white-matter-in-huntington-s-disease-using-mri
#5
JOURNAL ARTICLE
Annabelle Coleman, Mackenzie T Langan, Gaurav Verma, Harry Knights, Aaron Sturrock, Blair R Leavitt, Sarah J Tabrizi, Rachael I Scahill, Nicola Z Hobbs
BACKGROUND: Perivascular spaces (PVS) are fluid-filled cavities surrounding small cerebral blood vessels. There are limited reports of enlarged PVS across the grey matter in manifest Huntington's disease (HD). Little is known about how PVS morphometry in the white matter may contribute to HD. Enlarged PVS have the potential to both contribute to HD pathology and affect the distribution and success of intraparenchymal and intrathecally administered huntingtin-lowering therapies. OBJECTIVE: To investigate PVS morphometry in the global white matter across the spectrum of HD...
March 19, 2024: Journal of Huntington's Disease
https://read.qxmd.com/read/38495338/the-impact-of-quality-control-on-cortical-morphometry-comparisons-in-autism
#6
JOURNAL ARTICLE
Saashi A Bedford, Alfredo Ortiz-Rosa, Jenna M Schabdach, Manuela Costantino, Stephanie Tullo, Tom Piercy, Meng-Chuan Lai, Michael V Lombardo, Adriana Di Martino, Gabriel A Devenyi, M Mallar Chakravarty, Aaron F Alexander-Bloch, Jakob Seidlitz, Simon Baron-Cohen, Richard A I Bethlehem
Structural magnetic resonance imaging (MRI) quality is known to impact and bias neuroanatomical estimates and downstream analysis, including case-control comparisons, and a growing body of work has demonstrated the importance of careful quality control (QC) and evaluated the impact of image and image-processing quality. However, the growing size of typical neuroimaging datasets presents an additional challenge to QC, which is typically extremely time and labour intensive. One of the most important aspects of MRI quality is the accuracy of processed outputs, which have been shown to impact estimated neurodevelopmental trajectories...
October 1, 2023: Imaging Neurosci (Camb)
https://read.qxmd.com/read/38494136/two-multimodal-neuroimaging-subtypes-of-obsessive-compulsive-disorder-disclosed-by-semi-supervised-machine-learning
#7
JOURNAL ARTICLE
Zhipeng Ding, Tinghuizi Shang, Zhenning Ding, Xu Yang, Jiale Qi, Xiaoqing Qin, Yunhui Chen, Dan Lv, Tong Li, Jidong Ma, Chuang Zhan, Jian Xiao, Zhenghai Sun, Na Wang, Zengyan Yu, Chengchong Li, Ping Li
BACKGROUND: Obsessive-compulsive disorder (OCD) is a highly heterogeneous mental condition with a diverse symptom. Existing studies classified OCD on the basis of conventional phenomenology-based taxonomy ignoring the fact that the same subtype identified in accordance with clinical symptom may have different mechanisms and treatment responses. METHODS: This research involved 50 medicine-free patients with OCD and 50 matched healthy controls (HCs). All the participants were subjected to structural and functional magnetic resonance imaging (MRI)...
March 15, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38486948/parental-education-and-income-are-linked-to-offspring-cortical-brain-structure-and-psychopathology-at-9-11%C3%A2-years
#8
JOURNAL ARTICLE
Linn B Norbom, Jaroslav Rokicki, Espen M Eilertsen, Thea Wiker, Jamie Hanson, Andreas Dahl, Dag Alnæs, Sara Fernández-Cabello, Dani Beck, Ingrid Agartz, Ole A Andreassen, Lars T Westlye, Christian K Tamnes
BACKGROUND: A child's socioeconomic environment can shape central aspects of their life, including vulnerability to mental disorders. Negative environmental influences in youth may interfere with the extensive and dynamic brain development occurring at this time. Indeed, there are numerous yet diverging reports of associations between parental socioeconomic status (SES) and child cortical brain morphometry. Most of these studies have used single metric- or unimodal analyses of standard cortical morphometry that downplay the probable scenario where numerous biological pathways in sum account for SES-related cortical differences in youth...
March 2024: JCPP Adv
https://read.qxmd.com/read/38486858/improve-the-diagnosis-of-idiopathic-normal-pressure-hydrocephalus-by-combining-abnormal-cortical-thickness-and-ventricular-morphometry
#9
JOURNAL ARTICLE
Yifeng Yang, Meijing Yan, Xiao Liu, Shihong Li, Guangwu Lin
BACKGROUND: The primary imaging markers for idiopathic Normal Pressure Hydrocephalus (iNPH) emphasize morphological measurements within the ventricular system, with no attention given to alterations in brain parenchyma. This study aimed to investigate the potential effectiveness of combining ventricular morphometry and cortical structural measurements as diagnostic biomarkers for iNPH. METHODS: A total of 57 iNPH patients and 55 age-matched healthy controls (HC) were recruited in this study...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38478257/parkinson-s-disease-ca2-ca3-hippocampal-atrophy-is-accompanied-by-increased-cholinergic-innervation-in-patients-with-normal-cognition-but-not-in-patients-with-mild-cognitive-impairment
#10
JOURNAL ARTICLE
Camille Legault-Denis, Étienne Aumont, Kate M Onuska, Taylor W Schmitz, Aurélie Bussy, Mallar Chakravarty, Jean-Paul Soucy, Marc-André Bédard
Although brain cholinergic denervation has been largely associated with cognitive decline in patients with Parkinson's disease (PD), new evidence suggests that cholinergic upregulation occurs in the hippocampus of PD patients without cognitive deficits. The specific hippocampal sectors and potential mechanisms of this cholinergic compensatory process have been further studied here, using MRI volumetry and morphometry coupled with molecular imaging using the PET radiotracer [18 F]-Fluoroethoxybenzovesamicol ([18 F]-FEOBV)...
March 13, 2024: Brain Imaging and Behavior
https://read.qxmd.com/read/38475905/may-anti-seizure-medications-alter-brain-structure-in-temporal-lobe-epilepsy-a-prospective-study
#11
JOURNAL ARTICLE
Ilaria Sammarra, Maria Eugenia Caligiuri, Maria Celeste Bonacci, Gianfranco Di Gennaro, Francesco Fortunato, Iolanda Martino, Alessia Giugno, Angelo Labate, Antonio Gambardella
Mild mesial temporal lobe epilepsy (MTLE) patients may remain untreated for a considerable time after disease onset or achieve seizure control with a single anti-seizures medication (ASM). Thus, they represent an optimal population to investigate whether ASMs might have influence on brain structure. We consecutively enrolled 56 mild MTLE patients (22/56 untreated, 34/56 on-monotherapy) and 58 healthy controls, matched for age and gender. All subjects underwent 3T-brain MRI, using FreeSurfer for automated morphometry...
March 12, 2024: Epilepsia Open
https://read.qxmd.com/read/38469289/association-between-the-pittsburgh-sleep-quality-index-and-white-matter-integrity-in-healthy-adults-a-whole-brain-magnetic-resonance-imaging-study
#12
JOURNAL ARTICLE
Shinsuke Hidese, Miho Ota, Junko Matsuo, Ikki Ishida, Yuuki Yokota, Kotaro Hattori, Yukihito Yomogida, Hiroshi Kunugi
UNLABELLED: To disclose possible associations between poorer sleep quality and structural brain alterations in a non-psychiatric healthy population, this study investigated the association between the Pittsburgh sleep quality index (PSQI) and brain correlates, using a whole-brain approach. This study included 371 right-handed healthy adults (138 males, mean age: 46.4 ± 14.0 years [range: 18-75]) who were right-handed. Subjective sleep quality was assessed using the Japanese version of the PSQI (PSQI-J), and the cutoff score for poor subjective sleep quality was set at ≥ 6...
April 2023: Sleep and Biological Rhythms
https://read.qxmd.com/read/38466117/functional-and-structural-abnormalities-of-the-speech-disorders-a-multimodal-activation-likelihood-estimation-meta-analysis
#13
JOURNAL ARTICLE
Hao Cai, Jie Dong, Leilei Mei, Genyi Feng, Lili Li, Gang Wang, Hao Yan
Speech disorders are associated with different degrees of functional and structural abnormalities. However, the abnormalities associated with specific disorders, and the common abnormalities shown by all disorders, remain unclear. Herein, a meta-analysis was conducted to integrate the results of 70 studies that compared 1843 speech disorder patients (dysarthria, dysphonia, stuttering, and aphasia) to 1950 healthy controls in terms of brain activity, functional connectivity, gray matter, and white matter fractional anisotropy...
March 1, 2024: Cerebral Cortex
https://read.qxmd.com/read/38460394/alterations-in-cortical-thickness-of-frontoparietal-regions-in-patients-with-social-anxiety-disorder
#14
JOURNAL ARTICLE
Dasom Lee, Ye-Ha Jung, Suhyun Kim, Yoonji Irene Lee, Jeonghun Ku, Uicheul Yoon, Soo-Hee Choi
Although functional changes of the frontal and (para)limbic area for emotional hyper-reactivity and emotional dysregulation are well documented in social anxiety disorder (SAD), prior studies on structural changes have shown mixed results. This study aimed to identify differences in cortical thickness between SAD and healthy controls (CON). Thirty-five patients with SAD and forty-two matched CON underwent structural magnetic resonance imaging. A vertex-based whole brain and regional analyses were conducted for between-group comparison...
February 27, 2024: Psychiatry Research. Neuroimaging
https://read.qxmd.com/read/38452153/association-between-serum-nt-probnp-and-gray-matter-atrophy-patterns-in-an-older-japanese-population-the-hisayama-study
#15
JOURNAL ARTICLE
Naoki Hirabayashi, Jun Hata, Yoshihiko Furuta, Taro Nakazawa, Tomoyuki Ohara, Mao Shibata, Fumio Yamashita, Takanari Kitazono, Nobuyuki Sudo, Toshiharu Ninomiya
Several population-based studies have reported that higher serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are associated with brain morphological changes. However, no population-based studies have examined the relationship between serum NT-proBNP and various regional brain volumes in detail. We here analyzed the brain MRI data of 1,201 community-dwelling Japanese aged ≥65 years. Regional gray matter volumes (GMV) and intracranial volume (ICV) were estimated by applying voxel-based morphometry (VBM) methods...
March 7, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38450379/a-cross-sectional-observational-study-for-ethno-geographical-disparities-in-sleep-quality-brain-morphometry-and-cognition-a-solace-study-in-indians-residing-in-india-and-south-asians-and-europeans-residing-in-the-uk-a-study-protocol
#16
JOURNAL ARTICLE
Rishabh Soni, Caroline Dale, Victoria Garfield, Nasreen Akhtar
INTRODUCTION: As individuals age, their sleep patterns change, and sleep disturbances can increase the risk of dementia. Poor sleep quality can be a risk factor for mild cognitive impairment (MCI) and dementia. Epidemiological studies show a connection between sleep quality and cognitive changes, with brain imaging revealing grey matter volume reduction and amyloid beta accumulation in Alzheimer's disease. However, most research has focused on Europeans, with little attention to other ethnic groups...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38445545/mode-based-morphometry-a-multiscale-approach-to-mapping-human-neuroanatomy
#17
JOURNAL ARTICLE
Trang Cao, James C Pang, Ashlea Segal, Yu-Chi Chen, Kevin M Aquino, Michael Breakspear, Alex Fornito
Voxel-based morphometry (VBM) and surface-based morphometry (SBM) are two widely used neuroimaging techniques for investigating brain anatomy. These techniques rely on statistical inferences at individual points (voxels or vertices), clusters of points, or a priori regions-of-interest. They are powerful tools for describing brain anatomy, but offer little insights into the generative processes that shape a particular set of findings. Moreover, they are restricted to a single spatial resolution scale, precluding the opportunity to distinguish anatomical variations that are expressed across multiple scales...
March 2024: Human Brain Mapping
https://read.qxmd.com/read/38444906/impact-of-prenatal-marijuana-exposure-on-adolescent-brain-structural-and-functional-connectivity-and-behavioural-outcomes
#18
JOURNAL ARTICLE
Ramana V Vishnubhotla, Sidra T Ahmad, Yi Zhao, Rupa Radhakrishnan
There has been an increase in the number of women using marijuana whilst pregnant. Previous studies have shown that children with prenatal marijuana exposure have developmental deficits in memory and decreased attentiveness. In this study, we assess whether prenatal marijuana exposure is associated with alterations in brain regional morphometry and functional and structural connectivity in adolescents. We downloaded behavioural scores and subject image files from the Adolescent Brain Cognitive DevelopmentSM Study...
2024: Brain communications
https://read.qxmd.com/read/38441573/evaluation-of-the-structural-integrity-of-different-spinal-cord-tracts-with-magnetization-transfer-ratio-in-degenerative-cervical-myelopathy
#19
JOURNAL ARTICLE
Elena Filimonova, Mars Abdaev, Ivan Vasilenko, Yulij Kubetskij, Oleg Prokhorov, Jamil Rzaev
PURPOSE: Degenerative cervical myelopathy (DCM) is a common cause of spinal cord dysfunction. In this study, we explored the potential of magnetization transfer ratio (MTR) for evaluating the structural integrity of spinal cord tracts in patients with clinically significant DCM. METHODS: Fifty-three patients with DCM and 41 patients with cervical radiculopathy were evaluated using high-resolution cervical spinal cord magnetic resonance imaging (MRI), which included the magnetization transfer technique...
March 5, 2024: Neuroradiology
https://read.qxmd.com/read/38433204/common-and-distinct-cortical-thickness-alterations-in-youth-with-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder
#20
JOURNAL ARTICLE
Wanfang You, Qian Li, Lizhou Chen, Ning He, Yuanyuan Li, Fenghua Long, Yaxuan Wang, Yufei Chen, Robert K McNamara, John A Sweeney, Melissa P DelBello, Qiyong Gong, Fei Li
BACKGROUND: Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are neurodevelopmental disorders with overlapping behavioral features and genetic etiology. While brain cortical thickness (CTh) alterations have been reported in ASD and ADHD separately, the degree to which ASD and ADHD are associated with common and distinct patterns of CTh changes is unclear. METHODS: We searched PubMed, Web of Science, Embase, and Science Direct from inception to 8 December 2023 and included studies of cortical thickness comparing youth (age less than 18) with ASD or ADHD with typically developing controls (TDC)...
March 4, 2024: BMC Medicine
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