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Morphometry MRI

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https://www.readbyqxmd.com/read/29150855/thalamic-volume-reduction-in-drug-naive-patients-with-new-onset-genetic-generalized-epilepsy
#1
Suejen Perani, Tim M Tierney, Maria Centeno, Elhum A Shamshiri, Siti N Yaakub, Jonathan O'Muircheartaigh, David W Carmichael, Mark P Richardson
OBJECTIVE: Patients with genetic generalized epilepsy (GGE) have subtle morphologic abnormalities of the brain revealed with magnetic resonance imaging (MRI), particularly in the thalamus. However, it is unclear whether morphologic abnormalities of the brain in GGE are a consequence of repeated seizures over the duration of the disease, or are a consequence of treatment with antiepileptic drugs (AEDs), or are independent of these factors. Therefore, we measured brain morphometry in a cohort of AED-naive patients with GGE at disease onset...
November 18, 2017: Epilepsia
https://www.readbyqxmd.com/read/29145754/cortical-and-subcortical-brain-morphometry-differences-between-patients-with-autism-spectrum-disorder-and-healthy-individuals-across-the-lifespan-results-from-the-enigma-asd-working-group
#2
Daan van Rooij, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Marlene Behrmann, Geraldo F Busatto, Sara Calderoni, Eileen Daly, Christine Deruelle, Adriana Di Martino, Ilan Dinstein, Fabio Luis Souza Duran, Sarah Durston, Christine Ecker, Damien Fair, Jennifer Fedor, Jackie Fitzgerald, Christine M Freitag, Louise Gallagher, Ilaria Gori, Shlomi Haar, Liesbeth Hoekstra, Neda Jahanshad, Maria Jalbrzikowski, Joost Janssen, Jason Lerch, Beatriz Luna, Mauricio Moller Martinho, Jane McGrath, Filippo Muratori, Clodagh M Murphy, Declan G M Murphy, Kirsten O'Hearn, Bob Oranje, Mara Parellada, Alessandra Retico, Pedro Rossa, Katya Rubia, Devon Shook, Margot Taylor, Paul M Thompson, Michela Tosetti, Gregory L Wallace, Fengfeng Zhou, Jan K Buitelaar
OBJECTIVE: Neuroimaging studies show structural differences in both cortical and subcortical brain regions in children and adults with autism spectrum disorder (ASD) compared with healthy subjects. Findings are inconsistent, however, and it is unclear how differences develop across the lifespan. The authors investigated brain morphometry differences between individuals with ASD and healthy subjects, cross-sectionally across the lifespan, in a large multinational sample from the Enhancing Neuroimaging Genetics Through Meta-Analysis (ENIGMA) ASD working group...
November 17, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29136642/common-and-distinct-structural-features-of-schizophrenia-and-bipolar-disorder-the-european-network-on-psychosis-affective-disorders-and-cognitive-trajectory-enpact-study
#3
Eleonora Maggioni, Benedicto Crespo-Facorro, Igor Nenadic, Francesco Benedetti, Christian Gaser, Heinrich Sauer, Roberto Roiz-Santiañez, Sara Poletti, Veronica Marinelli, Marcella Bellani, Cinzia Perlini, Mirella Ruggeri, A Carlo Altamura, Vaibhav A Diwadkar, Paolo Brambilla
INTRODUCTION: Although schizophrenia (SCZ) and bipolar disorder (BD) share elements of pathology, their neural underpinnings are still under investigation. Here, structural Magnetic Resonance Imaging (MRI) data collected from a large sample of BD and SCZ patients and healthy controls (HC) were analyzed in terms of gray matter volume (GMV) using both voxel based morphometry (VBM) and a region of interest (ROI) approach. METHODS: The analysis was conducted on two datasets, Dataset1 (802 subjects: 243 SCZ, 176 BD, 383 HC) and Dataset2, a homogeneous subset of Dataset1 (301 subjects: 107 HC, 85 BD and 109 SCZ)...
2017: PloS One
https://www.readbyqxmd.com/read/29129723/neural-correlates-of-impaired-self-regulation-in-male-youths-with-autism-spectrum-disorder-a-voxel-based-morphometry-study
#4
Hsing-Chang Ni, Hsiang-Yuan Lin, Wen-Yih Isaac Tseng, Yen-Nan Chiu, Yu-Yu Wu, Wen-Che Tsai, Susan Shur-Fen Gau
Although recent studies revealed impaired self-regulation (dysregulation) in autism spectrum disorder (ASD), neural correlates of dysregulation and its impacts on autistic neuroanatomy remain unclear. Voxel-based morphometry was applied on structural MRI images in 81 ASD and 61 typically developing (TD) boys aged 7-17years. Dysregulation was defined by the sum of T-scores of Attention, Aggression, and Anxiety/Depression subscales in the Child Behavior Checklist>180. There were 53 and 28 boys in the ASD+Dysregulation and ASD-Dysregulation groups, respectively...
November 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29128164/grey-matter-volume-loss-is-associated-with-specific-clinical-motor-signs-in-huntington-s-disease
#5
Emma M Coppen, Milou Jacobs, Annette A van den Berg-Huysmans, Jeroen van der Grond, Raymund A C Roos
BACKGROUND: Motor disturbances are clinical hallmarks of Huntington's disease (HD) and involve chorea, dystonia, hypokinesia and visuomotor dysfunction. Investigating the association between specific motor signs and different regional volumes is important to understand the heterogeneity of HD. OBJECTIVE: To investigate the motor phenotype of HD and associations with subcortical and cortical grey matter volume loss. METHODS: Structural T1-weighted MRI scans of 79 HD patients and 30 healthy controls were used to calculate volumes of seven subcortical structures including the nucleus accumbens, hippocampus, thalamus, caudate nucleus, putamen, pallidum and amygdala...
November 2, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29117580/discovery-and-visualization-of-structural-biomarkers-from-mri-using-transport-based-morphometry
#6
Shinjini Kundu, Soheil Kolouri, Kirk I Erickson, Arthur F Kramer, Edward McAuley, Gustavo K Rohde
Disease in the brain is often associated with subtle, spatially diffuse, or complex tissue changes that may lie beneath the level of gross visual inspection, even on magnetic resonance imaging (MRI). Unfortunately, current computer-assisted approaches that examine pre-specified features, whether anatomically-defined (i.e. thalamic volume, cortical thickness) or based on pixelwise comparison (i.e. deformation-based methods), are prone to missing a vast array of physical changes that are not well-encapsulated by these metrics...
November 5, 2017: NeuroImage
https://www.readbyqxmd.com/read/29113251/structural-mri-research-in-patients-with-nasopharyngeal-carcinoma-following-radiotherapy-a-dti-and-vbm-study
#7
Xi Leng, Peng Fang, Huan Lin, Jie An, Xin Tan, Chi Zhang, Donglin Wu, Wen Shen, Shijun Qiu
The aim of the present study was to investigate the microstructural characteristics of the brain lobes following radiotherapy (RT) for patients with nasopharyngeal carcinoma (NPC) at distinct times. Diffusion tensor imaging (DTI) and 3D-T1-weighted imaging was performed in 70 age- and sex-matched subjects, 24 of whom were pre-treatment patients. The patients were divided into three groups, according to the time following completion of RT. Fractional anisotropy (FA) and gray matter (GM) volume were determined...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29111383/disturbed-glutathione-antioxidative-defense-is-associated-with-structural-brain-changes-in-neuroleptic-na%C3%A3-ve-first-episode-psychosis-patients
#8
K Langbein, J Hesse, A Gussew, B Milleit, S Lavoie, G P Amminger, C Gaser, G Wagner, J R Reichenbach, U-C Hipler, D Winter, S Smesny
BACKGROUND: Oxidative stress and impaired antioxidant defense are reported in schizophrenia and are thought to be associated with disturbed neurodevelopment, brain structural alterations, glutamatergic imbalance, negative symptomatology, and cognitive impairment. To test some of these assumptions we investigated the glutathione (GSH) antioxidant defense system (AODS) and brain structural abnormalities in drug-naïve individuals with first acute episode of psychosis (FEP). METHOD: The study involved 27 drug-naïve FEP patients and 31 healthy controls (HC)...
October 18, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29105886/altered-structure-and-functional-connection-in-patients-with-classical-trigeminal-neuralgia
#9
Yuan-Hsiung Tsai, Rui Yuan, Dharni Patel, Subhashini Chandrasekaran, Hsu-Huei Weng, Jen-Tsung Yang, Ching-Po Lin, Bharat B Biswal
Classical trigeminal neuralgia (TN) is a specific type of neuropathic orofacial pain of which the plasticity of brain structure and connectivity have remained largely unknown. A total of 62 TN patients were included and referred to MRI scans. Voxel-based morphometry was used to analyze the change of gray matter volume. Resting-state functional imaging was used to analyze the connectivity between brain regions. The results showed gray matter volume reduction in components of the prefrontal cortex, precentral gyrus, cerebellar tonsil, thalamus, hypothalamus, and nucleus accumbens among right TN patient and in the inferior frontal gyrus, precentral gyrus, cerebellum, thalamus, ventral striatum, and putamen among left TN patients...
November 6, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29104740/cerebellum-and-neurodegenerative-diseases-beyond-conventional-magnetic-resonance-imaging
#10
REVIEW
Enricomaria Mormina, Maria Petracca, Giulia Bommarito, Niccolò Piaggio, Sirio Cocozza, Matilde Inglese
The cerebellum plays a key role in movement control and in cognition and cerebellar involvement is described in several neurodegenerative diseases. While conventional magnetic resonance imaging (MRI) is widely used for brain and cerebellar morphologic evaluation, advanced MRI techniques allow the investigation of cerebellar microstructural and functional characteristics. Volumetry, voxel-based morphometry, diffusion MRI based fiber tractography, resting state and task related functional MRI, perfusion, and proton MR spectroscopy are among the most common techniques applied to the study of cerebellum...
October 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/29090500/five-minute-knee-mri-for-simultaneous-morphometry-and-t2-relaxometry-of-cartilage-and-meniscus-and-for-semiquantitative-radiological-assessment-using-double-echo-in-steady-state-at-3t
#11
Akshay S Chaudhari, Marianne S Black, Susanne Eijgenraam, Wolfgang Wirth, Susanne Maschek, Bragi Sveinsson, Felix Eckstein, Edwin H G Oei, Garry E Gold, Brian A Hargreaves
BACKGROUND: Biomarkers for assessing osteoarthritis activity necessitate multiple MRI sequences with long acquisition times. PURPOSE: To perform 5-minute simultaneous morphometry (thickness/volume measurements) and T2 relaxometry of both cartilage and meniscus, and semiquantitative MRI Osteoarthritis Knee Scoring (MOAKS). STUDY TYPE: Prospective. SUBJECTS: Fifteen healthy volunteers for morphometry and T2 measurements, and 15 patients (five each Kellgren-Lawrence grades 0/2/3) for MOAKS assessment...
November 1, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29079677/can-we-predict-development-of-impulsive-compulsive-behaviours-in-parkinson-s-disease
#12
Lucia Ricciardi, Christian Lambert, Rosa De Micco, Francesca Morgante, Mark Edwards
OBJECTIVE: To determine clinical and structural imaging predictors of impulsive-compulsive behaviour (ICB) in de novo Parkinson's disease (PD). METHODS: From a cohort of 1116 subjects from the Parkinson's Progression Marker Initiative database, we created a subcohort of 42 de novo PD without ICB at baseline with available 3T MRI and who developed ICB during follow-up. PD-ICB were matched for age, gender and disease duration to 42 patients with PD without ICB over follow-up (PD-no-ICB) and 42 healthy controls (HCs)...
October 27, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29079398/the-neural-correlates-of-apathy-in-schizophrenia-an-exploratory-investigation
#13
Fernando Caravaggio, Gagan Fervaha, Mahesh Menon, Gary Remington, Ariel Graff-Guerrero, Philip Gerretsen
BACKGROUND: Motivational deficits represent a core negative symptom in patients with schizophrenia. Previous morphology studies have demonstrated that apathy in patients with schizophrenia is associated with reduced frontal grey matter (GM). We attempted to replicate this previous finding, and explored whether it was distinct from potential associations with a distinct subdomain of negative symptoms, namely Affective Flattening, and GM. METHODS: Twenty medicated patients with schizophrenia provided structural T1-weighted images acquired on a 3-Tesla MRI scanner and negative symptoms were evaluated using the Scale for the Assessment of Negative Symptoms...
October 24, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29065207/cerebellar-gray-matter-reductions-associate-with-decreased-functional-connectivity-in-nicotine-dependent-individuals
#14
Zhujing Shen, Peiyu Huang, Chao Wang, Wei Qian, Yihong Yang, Minming Zhang
Introduction: Nicotine dependence (ND) is a chronic, relapsing mental disorder characterized by compulsive cigarette seeking and smoking. Although the cerebellum plays an increasingly implicated role in ND, the exact cerebellar alterations in ND remain unclear. Identifying the localization of these cerebellar abnormalities in ND may help to further understand the role of the cerebellum in ND. Thus, we investigated the structural and functional alterations in the cerebellum in a large sample of smokers using the spatially unbiased infratentorial template (SUIT)...
July 27, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29063467/correlations-between-dopamine-transporter-density-measured-by-123-i-fp-cit-spect-and-regional-gray-matter-volume-in-parkinson-s-disease
#15
Tomoko Maekawa, Noriko Sato, Miho Ota, Atsuhiko Sugiyama, Daichi Sone, Mikako Enokizono, Yukio Kimura, Youhei Mukai, Miho Murata, Harumasa Takano, Etsuko Imabayashi, Hiroshi Matsuda, Akira Kunimatsu, Osamu Abe
PURPOSE: Parkinson's disease (PD) is caused by a selective degeneration of dopamine neurons. The relationship between dopamine transporter (DAT) density and gray matter volume has been unclear. Here we investigated the voxelwise correlation between gray matter volume and DAT binding measured by (123)I-N-ω-fluoropropyl-2β-carboxymethoxy-3β-(4-iodophenyl)nortropane ((123)I-FP-CIT) single-photon emission computed tomography (SPECT; DaTscan™ imaging) in PD. MATERIALS AND METHODS: Thirty-one male patients with PD were examined with MRI and DaTscan...
October 23, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29039414/-the-limbic-system-in-youth-depression-brain-structural-and-functional-alterations-in-adolescent-in-patients-with-severe-depression
#16
Ronny Redlich, Nils Opel, Christian Bürger, Katharina Dohm, Dominik Grotegerd, Katharina Förster, Dario Zaremba, Susanne Meinert, Jonathan Repple, Verena Enneking, Elisabeth Leehr, Joshua Böhnlein, Lena Winters, Neele Froböse, Sophia Thrun, Julia Emtmann, Walter Heindel, Harald Kugel, Volker Arolt, Georg Romer, Christian Postert, Udo Dannlowski
Adolescent-onset Major Depressive Disorder (MDD) is associated with an increased risk of recurrent depressive episodes, suicidal behaviors, and psychiatric morbidity throughout the lifespan. The objective of the present study was to investigate brain structural and functional changes in adolescent patients with MDD. Furthermore, we aimed to clarify the influence of early-life stress on brain function and structure. The study investigated adolescent patients with severe MDD (n=20, mean age=16.0, range=15-18 years) and a control sample of matched healthy adolescents (n=21, mean age= 16...
October 17, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29038494/a-study-of-the-brain-abnormalities-of-post-stroke-depression-in-frontal-lobe-lesion
#17
Yu Shi, Yanyan Zeng, Lei Wu, Wei Liu, Ziping Liu, Shanshan Zhang, Jianming Yang, Wen Wu
Post stroke depression (PSD) is a serious complication of stroke. Brain imaging is an important method of studying the mechanism of PSD. However, few studies have focused on the single lesion location. The aim of this study was to investigate the brain mechanism of frontal lobe PSD using combined voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI). In total, 30 first-time ischemic frontal lobe stroke patients underwent T1 weighted MRI and resting-state fMRI scans. Clinical assessments included the 24-item Hamilton Rating Scale for Depression, the National Institutes of Health Stroke Scale, and the Mini-Mental State Examination...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29036371/additive-effect-of-cigarette-smoking-on-gray-matter-abnormalities-in-schizophrenia
#18
Naoto Yokoyama, Hitoshi Sasaki, Yasuo Mori, Miki Ono, Kousuke Tsurumi, Ryosaku Kawada, Yukiko Matsumoto, Yujiro Yoshihara, Genichi Sugihara, Jun Miyata, Toshiya Murai, Hidehiko Takahashi
It is widely known that there is a high prevalence of cigarette smoking in schizophrenia. One of the explanations is the self-medication hypothesis. Based on this hypothesis, it has been suggested that nicotine has procognitive effect or even neuroprotective effect in schizophrenia. However, cigarettes contain numerous neurotoxic substances, making the net effect of cigarette smoking on brain function and structure complex. Indeed, recent studies have called into question the self-medication hypothesis. We aimed to test whether there is an interaction between diagnosis and smoking status in gray matter volume, ie, whether smoking has specific effects on gray matter or whether main effects of these 2 variables additively affect common brain regions...
July 14, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29034509/3d-diffusion-weighted-129-xe-mri-for-whole-lung-morphometry
#19
Ho-Fung Chan, Neil J Stewart, Graham Norquay, Guilhem J Collier, Jim M Wild
PURPOSE: To obtain whole lung morphometry measurements from (129) Xe in a single breath-hold with 3D multiple b-value (129) Xe diffusion-weighted MRI (DW-MRI) with an empirically optimized diffusion time and compressed sensing for scan acceleration. METHODS: Prospective three-fold undersampled 3D multiple b-value hyperpolarized (129) Xe DW-MRI datasets were acquired, and the diffusion time (Δ) was iterated so as to provide diffusive length scale (LmD ) estimates from the stretched exponential model (SEM) that are comparable to those from (3) He...
October 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29030455/optimal-deep-brain-stimulation-site-and-target-connectivity-for-chronic-cluster-headache
#20
Harith Akram, Sarah Miller, Susie Lagrata, Marwan Hariz, John Ashburner, Tim Behrens, Manjit Matharu, Ludvic Zrinzo
OBJECTIVE: To investigate the mechanism of action of deep brain stimulation for refractory chronic cluster headache and the optimal target within the ventral tegmental area. METHODS: Seven patients with refractory chronic cluster headache underwent high spatial and angular resolution diffusion MRI preoperatively. MRI-guided and MRI-verified electrode implantation was performed unilaterally in 5 patients and bilaterally in 2. Volumes of tissue activation were generated around active lead contacts with a finite-element model...
October 13, 2017: Neurology
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