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Morphometry MRI

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https://www.readbyqxmd.com/read/28426817/evaluation-of-machine-learning-algorithms-and-structural-features-for-optimal-mri-based-diagnostic-prediction-in-psychosis
#1
Raymond Salvador, Joaquim Radua, Erick J Canales-Rodríguez, Aleix Solanes, Salvador Sarró, José M Goikolea, Alicia Valiente, Gemma C Monté, María Del Carmen Natividad, Amalia Guerrero-Pedraza, Noemí Moro, Paloma Fernández-Corcuera, Benedikt L Amann, Teresa Maristany, Eduard Vieta, Peter J McKenna, Edith Pomarol-Clotet
A relatively large number of studies have investigated the power of structural magnetic resonance imaging (sMRI) data to discriminate patients with schizophrenia from healthy controls. However, very few of them have also included patients with bipolar disorder, allowing the clinically relevant discrimination between both psychotic diagnostics. To assess the efficacy of sMRI data for diagnostic prediction in psychosis we objectively evaluated the discriminative power of a wide range of commonly used machine learning algorithms (ridge, lasso, elastic net and L0 norm regularized logistic regressions, a support vector classifier, regularized discriminant analysis, random forests and a Gaussian process classifier) on main sMRI features including grey and white matter voxel-based morphometry (VBM), vertex-based cortical thickness and volume, region of interest volumetric measures and wavelet-based morphometry (WBM) maps...
2017: PloS One
https://www.readbyqxmd.com/read/28425061/gray-matter-and-white-matter-changes-in-non-demented-amyotrophic-lateral-sclerosis-patients-with-or-without-cognitive-impairment-a-combined-voxel-based-morphometry-and-tract-based-spatial-statistics-whole-brain-analysis
#2
Foteini Christidi, Efstratios Karavasilis, Franz Riederer, Ioannis Zalonis, Panagiotis Ferentinos, Georgios Velonakis, Sophia Xirou, Michalis Rentzos, Georgios Argiropoulos, Vasiliki Zouvelou, Thomas Zambelis, Athanasios Athanasakos, Panagiotis Toulas, Konstantinos Vadikolias, Efstathios Efstathopoulos, Spyros Kollias, Nikolaos Karandreas, Nikolaos Kelekis, Ioannis Evdokimidis
The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients show structural changes within but also beyond the motor cortex and corticospinal tract and furthermore outside the frontal lobes, even if frank dementia is not detected. The aim of the present study was to investigate both gray matter (GM) and white matter (WM) changes in non-demented amyotrophic lateral sclerosis (ALS) patients with or without cognitive impairment (ALS-motor and ALS-plus, respectively). Nineteen ALS-motor, 31 ALS-plus and 25 healthy controls (HC) underwent 3D-T1-weighted and 30-directional diffusion-weighted imaging on a 3 T MRI scanner...
April 19, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28420876/examining-gray-matter-structure-associated-with-academic-performance-in-a-large-sample-of-chinese-high-school-students
#3
Song Wang, Ming Zhou, Taolin Chen, Xun Yang, Guangxiang Chen, Meiyun Wang, Qiyong Gong
Achievement in school is crucial for students to be able to pursue successful careers and lead happy lives in the future. Although many psychological attributes have been found to be associated with academic performance, the neural substrates of academic performance remain largely unknown. Here, we investigated the relationship between brain structure and academic performance in a large sample of high school students via structural magnetic resonance imaging (S-MRI) using voxel-based morphometry (VBM) approach...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28412941/survival-prediction-in-amyotrophic-lateral-sclerosis-based-on-mri-measures-and-clinical-characteristics
#4
Christina Schuster, Orla Hardiman, Peter Bede
BACKGROUND: Amyotrophic lateral sclerosis (ALS) a highly heterogeneous neurodegenerative condition. Accurate diagnostic, monitoring and prognostic biomarkers are urgently needed both for individualised patient care and clinical trials. A multimodal magnetic resonance imaging study is presented, where MRI measures of ALS-associated brain regions are utilised to predict 18-month survival. METHODS: A total of 60 ALS patients and 69 healthy controls were included in this study...
April 17, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28408879/comparison-of-in-vivo-and-ex-vivo-mri-for-the-detection-of-structural-abnormalities-in-a-mouse-model-of-tauopathy
#5
Holly E Holmes, Nick M Powell, Da Ma, Ozama Ismail, Ian F Harrison, Jack A Wells, Niall Colgan, James M O'Callaghan, Ross A Johnson, Tracey K Murray, Zeshan Ahmed, Morten Heggenes, Alice Fisher, M Jorge Cardoso, Marc Modat, Michael J O'Neill, Emily C Collins, Elizabeth M C Fisher, Sébastien Ourselin, Mark F Lythgoe
With increasingly large numbers of mouse models of human disease dedicated to MRI studies, compromises between in vivo and ex vivo MRI must be fully understood in order to inform the choice of imaging methodology. We investigate the application of high resolution in vivo and ex vivo MRI, in combination with tensor-based morphometry (TBM), to uncover morphological differences in the rTg4510 mouse model of tauopathy. The rTg4510 mouse also offers a novel paradigm by which the overexpression of mutant tau can be regulated by the administration of doxycycline, providing us with a platform on which to investigate more subtle alterations in morphology with morphometry...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28396646/regional-gray-matter-volume-is-associated-with-restrained-eating-in-healthy-chinese-young-adults-evidence-from-voxel-based-morphometry
#6
Yanhua Su, Todd Jackson, Dongtao Wei, Jiang Qiu, Hong Chen
Highlight Participants were non-clinical young adults with different restrained eating levels.We assessed relations of restrained eating (RE) with regional gray matter volume (rGMV).High RE scores were related to larger GMV in specific areas related to reward.High RE scores were also linked to less GMV in regions related to response inhibition. Objective: Dieting is a popular method of weight control. However, few dieters are able to maintain initial weight losses over an extended period of time. Why do most restrained dieters fail to lose weight? Alterations in brain structures associated with restrained eating (RE) represent one potentially important mechanism that contributes to difficulties in maintaining weight loss within this group...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28394230/advanced-mri-techniques-biomarkers-in-neuropsychiatric-lupus
#7
N Sarbu, P Toledano, A Calvo, E Roura, M I Sarbu, G Espinosa, X Lladó, R Cervera, N Bargalló
Objectives The objective of this study was to determine whether advanced MRI could provide biomarkers for diagnosis and prognosis in neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Our prospective study included 28 systemic lupus erythematosus (SLE) patients with primary central NPSLE, 22 patients without NPSLE and 20 healthy controls. We used visual scales to evaluate atrophy and white matter hyperintensities, voxel-based morphometry and Freesurfer to measure brain volume, plus diffusion-tensor imaging (DTI) to assess white matter (WM) and gray matter (GM) damage...
April 2017: Lupus
https://www.readbyqxmd.com/read/28389386/coordinate-based-random-effect-size-meta-analysis-of-neuroimaging-studies
#8
C R Tench, Radu Tanasescu, C S Constantinescu, D P Auer, W J Cottam
Low power in neuroimaging studies can make them difficult to interpret, and Coordinate based meta-analysis (CBMA) may go some way to mitigating this issue. CBMA has been used in many analyses to detect where published functional MRI or voxel-based morphometry studies testing similar hypotheses report significant summary results (coordinates) consistently. Only the reported coordinates and possibly t statistics are analysed, and statistical significance of clusters is determined by coordinate density. Here a method of performing coordinate based random effect size meta-analysis and meta-regression is introduced...
April 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28387678/memory-is-not-enough-the-neurobiological-substrates-of-dynamic-cognitive-reserve
#9
Laura Serra, Michela Bruschini, Carlotta Di Domenico, Giulia Bechi Gabrielli, Camillo Marra, Carlo Caltagirone, Mara Cercignani, Marco Bozzali
Changes in the residual memory variance are considered as a dynamic aspect of cognitive reserve (d-CR). We aimed to investigate for the first time the neural substrate associated with changes in the residual memory variance overtime in patients with amnestic mild cognitive impairment (aMCI). Thirty-four aMCI patients followed-up for 36 months and 48 healthy elderly individuals (HE) were recruited. All participants underwent 3T MRI, collecting T1-weighted images for voxel-based morphometry (VBM). They underwent an extensive neuropsychological battery, including six episodic memory tests...
April 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28384958/application-of-curved-mpr-algorithm-to-high-resolution-3-dimensional-t2-weighted-ciss-images-for-virtual-uncoiling-of-membranous-cochlea-as-an-aid-for-cochlear-morphometry
#10
Joish Upendra Kumar, Y Kavitha
INTRODUCTION: With the use of various surgical techniques, types of implants, the preoperative assessment of cochlear dimensions is becoming increasingly relevant prior to cochlear implantation. High resolution CISS protocol MRI gives a better assessment of membranous cochlea, cochlear nerve, and membranous labyrinth. Curved Multiplanar Reconstruction (MPR) algorithm provides better images that can be used for measuring dimensions of membranous cochlea. AIM: To ascertain the value of curved multiplanar reconstruction algorithm in high resolution 3-Dimensional T2 Weighted Gradient Echo Constructive Interference Steady State (3D T2W GRE CISS) imaging for accurate morphometry of membranous cochlea...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28374074/abnormal-subcortical-nuclei-shapes-in-patients-with-type-2-diabetes-mellitus
#11
Ji Chen, Junxiang Zhang, Xuebing Liu, Xiaoyang Wang, Xiangjin Xu, Hui Li, Bo Cao, Yanqiu Yang, Jingjing Lu, Ziqian Chen
OBJECTIVES: Type 2 diabetes mellitus (T2DM) increases the risk of brain atrophy and dementia. We aimed to elucidate deep grey matter (GM) structural abnormalities and their relationships with T2DM cognitive deficits by combining region of interest (ROI)-based volumetry, voxel-based morphometry (VBM) and shape analysis. METHODS: We recruited 23 T2DM patients and 24 age-matched healthy controls to undergo T1-weighted structural MRI scanning. Images were analysed using the three aforementioned methods to obtain deep GM structural shapes and volumes...
April 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28370153/mri-reveals-therapeutical-efficacy-of-stem-cells-an-experimental-study-on-the-sod1-g93a-animal-model
#12
Pietro Bontempi, Alice Busato, Roberta Bonafede, Lorenzo Schiaffino, Ilaria Scambi, Andrea Sbarbati, Raffaella Mariotti, Pasquina Marzola
PURPOSE: The first part of the experiment identifies and validates MRI biomarkers distinctive of the disease progression in the transgenic superoxide dismutase gene (SOD1(G93A)) animal model. The second part assesses the efficacy of a mesenchymal stem cell-based therapy through the MRI biomarkers previously defined. METHODS: The first part identifies MRI differences between SOD1(G93A) and healthy mice. The second part of the experiment follows the disease evolution of stem cell-treated and non-stem-cell treated SOD1(G93A) mice...
March 31, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28369850/an-mri-study-of-the-corpus-callosum-in-monkeys-developmental-trajectories-and-effects-of-neonatal-hippocampal-and-amygdala-lesions
#13
Christa Payne, Laetitia Cirilli, Jocelyne Bachevalier
This study provides the first characterization of early developmental trajectories of corpus callosum (CC) segments in rhesus macaques using noninvasive MRI techniques and assesses long-term effects of neonatal amygdala or hippocampal lesions on CC morphometry. In Experiment 1, 10 monkeys (5 males) were scanned at 1 week-2 years of age; eight additional infants (4 males) were scanned once at 1-4 weeks of age. The first 8 months showed marked growth across all segments, with sustained, albeit slower, growth through 24 months...
May 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28351446/on-the-relationship-between-head-circumference-brain-size-prenatal-long-chain-pufa-5-methyltetrahydrofolate-supplementation-and-cognitive-abilities-during-childhood
#14
Andrés Catena, Cristina Martínez-Zaldívar, Carolina Diaz-Piedra, Francisco J Torres-Espínola, Pilar Brandi, Miguel Pérez-García, Tamás Decsi, Berthold Koletzko, Cristina Campoy
Head circumference in infants has been reported to predict brain size, total grey matter volume (GMV) and neurocognitive development. However, it is unknown whether it has predictive value on regional and subcortical brain volumes. We aimed to explore the relationship between several head circumference measurements since birth and distributions of GMV and subcortical volumes at later childhood. We examined seventy-four, Caucasian, singleton, term-born infants born to mothers randomised to receive fish oil and/or 5-methyltetrahydrofolate or placebo prenatal supplementation...
March 29, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28348952/radiation-induced-abnormal-cortical-thickness-in-patients-with-nasopharyngeal-carcinoma-after-radiotherapy
#15
Jiabao Lin, Xiaofei Lv, Meiqi Niu, Lizhi Liu, Jun Chen, Fei Xie, Miao Zhong, Shijun Qiu, Li Li, Ruiwang Huang
Conventional MRI studies showed that radiation-induced brain necrosis in patients with nasopharyngeal carcinoma (NPC) in years after radiotherapy (RT) could involve brain gray matter (GM) and impair brain function. However, it is still unclear the radiation-induced brain morphological changes in NPC patients with normal-appearing GM in the early period after RT. In this study, we acquired high-resolution brain structural MRI data from three groups of patients, 22 before radiotherapy (pre-RT) NPC patients with newly diagnosed but not yet medically treated, 22 NPC patients in the early-delayed stage after radiotherapy (post-RT-ED), and 20 NPC patients in the late-delayed stage after radiotherapy (post-RT-LD), and then analyzed the radiation-induced cortical thickness alteration in NPC patients after RT...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28341715/can-mri-visual-assessment-differentiate-the-variants-of-primary-progressive-aphasia
#16
S A Sajjadi, N Sheikh-Bahaei, J Cross, J H Gillard, D Scoffings, P J Nestor
BACKGROUND AND PURPOSE: Primary-progressive aphasia is a clinically and pathologically heterogeneous condition. Nonfluent, semantic, and logopenic are the currently recognized clinical variants. The recommendations for the classification of primary-progressive aphasia have advocated variant-specific patterns of atrophy. The aims of the present study were to evaluate the sensitivity and specificity of the proposed imaging criteria and to assess the intra- and interrater reporting agreements...
March 24, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28337409/network-degeneration-and-dysfunction-in-presymptomatic-c9orf72-expansion-carriers
#17
Suzee E Lee, Ana C Sias, Maria Luisa Mandelli, Jesse A Brown, Alainna B Brown, Anna M Khazenzon, Anna A Vidovszky, Theodore P Zanto, Anna M Karydas, Mochtar Pribadi, Deepika Dokuru, Giovanni Coppola, Dan H Geschwind, Rosa Rademakers, Maria Luisa Gorno-Tempini, Howard J Rosen, Bruce L Miller, William W Seeley
Hexanucleotide repeat expansions in C9ORF72 are the most common known genetic cause of familial and sporadic frontotemporal dementia and amyotrophic lateral sclerosis. Previous work has shown that patients with behavioral variant frontotemporal dementia due to C9ORF72 show salience and sensorimotor network disruptions comparable to those seen in sporadic behavioral variant frontotemporal dementia, but it remains unknown how early in the lifespan these and other changes in brain structure and function arise...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28332625/brain-anatomy-alterations-associated-with-social-networking-site-sns-addiction
#18
Qinghua He, Ofir Turel, Antoine Bechara
This study relies on knowledge regarding the neuroplasticity of dual-system components that govern addiction and excessive behavior and suggests that alterations in the grey matter volumes, i.e., brain morphology, of specific regions of interest are associated with technology-related addictions. Using voxel based morphometry (VBM) applied to structural Magnetic Resonance Imaging (MRI) scans of twenty social network site (SNS) users with varying degrees of SNS addiction, we show that SNS addiction is associated with a presumably more efficient impulsive brain system, manifested through reduced grey matter volumes in the amygdala bilaterally (but not with structural differences in the Nucleus Accumbens)...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28328939/multimodal-mr-imaging-reveals-large-scale-structural-and-functional-connectivity-changes-in-profound-early-blindness
#19
Corinna M Bauer, Gabriella V Hirsch, Lauren Zajac, Bang-Bon Koo, Olivier Collignon, Lotfi B Merabet
In the setting of profound ocular blindness, numerous lines of evidence demonstrate the existence of dramatic anatomical and functional changes within the brain. However, previous studies based on a variety of distinct measures have often provided inconsistent findings. To help reconcile this issue, we used a multimodal magnetic resonance (MR)-based imaging approach to provide complementary structural and functional information regarding this neuroplastic reorganization. This included gray matter structural morphometry, high angular resolution diffusion imaging (HARDI) of white matter connectivity and integrity, and resting state functional connectivity MRI (rsfcMRI) analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28327107/brain-structure-differences-among-male-schizophrenic-patients-with-history-of-serious-violent-acts-an-mri-voxel-based-morphometric-study
#20
Noriomi Kuroki, Hiroko Kashiwagi, Miho Ota, Masanori Ishikawa, Hiroshi Kunugi, Noriko Sato, Naotsugu Hirabayashi, Toshio Ota
BACKGROUND: The biological underpinnings of serious violent behaviors in patients with schizophrenia remain unclear. The aim of this study was to identify the characteristics of brain morphometry in patients with schizophrenia and a history of serious violent acts, who were being treated under relatively new legislation for offenders with mental illness in Japan where their relevant action should be strongly associated with their mental illness. We also investigated whether morphometric changes would depend on types of serious violent actions or not...
March 21, 2017: BMC Psychiatry
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