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Morphometry MRI

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https://www.readbyqxmd.com/read/28109978/structural-brain-alteration-in-survivors-of-acute-lymphoblastic-leukemia-with-chemotherapy-treatment-a-voxel-based-morphometry-and-diffusion-tensor-imaging-study
#1
Liwei Zou, Lianzi Su, Jiajia Xu, Li Xiang, Longsheng Wang, Zhimin Zhai, Suisheng Zheng
OBJECTIVE: To assess structural brain changes in survivors of acute lymphoblastic leukemia (ALL) with chemotherapy treatment by combining voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS). METHODS: 28 ALL patients (mean age: 40.71±8.58 years, years since diagnosis: 7-38) and 20 age-matched control subjects (mean age: 42.95±6.39 years) selected in this study with 3D T1 and diffusion tensor imaging acquired on a 3.0T Siemens MRI scanner. The ALL group had a history of chemotherapy treatment and off-therapy at least for 3 years was enrolled...
January 18, 2017: Brain Research
https://www.readbyqxmd.com/read/28101700/predicting-brain-metastases-for-non-small-cell-lung-cancer-based-on-magnetic-resonance-imaging
#2
Gang Yin, Churong Li, Heng Chen, Yangkun Luo, Lucia Clara Orlandini, Pei Wang, Jinyi Lang
In this study the relationship between brain structure and brain metastases (BM) occurrence was analyzed. A model for predicting the time of BM onset in patients with non-small cell lung cancer (NSCLC) was proposed. Twenty patients were used to develop the model, whereas the remaining 69 were used for independent validation and verification of the model. Magnetic resonance images were segmented into cerebrospinal fluid, gray matter (GM), and white matter using voxel-based morphometry. Automatic anatomic labeling template was used to extract 116 brain regions from the GM volume...
January 18, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28099507/correlations-of-behavioral-deficits-with-brain-pathology-assessed-through-longitudinal-mri-and-histopathology-in-the-hdhq150-q150-mouse-model-of-huntington-s-disease
#3
Ivan Rattray, Edward J Smith, William R Crum, Thomas A Walker, Richard Gale, Gillian P Bates, Michel Modo
A variety of mouse models have been developed that express mutant huntingtin (mHTT) leading to aggregates and inclusions that model the molecular pathology observed in Huntington's disease. Here we show that although homozygous HdhQ150 knock-in mice developed motor impairments (rotarod, locomotor activity, grip strength) by 36 weeks of age, cognitive dysfunction (swimming T maze, fear conditioning, odor discrimination, social interaction) was not evident by 94 weeks. Concomitant to behavioral assessments, T2-weighted MRI volume measurements indicated a slower striatal growth with a significant difference between wild type (WT) and HdhQ150 mice being present even at 15 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28094824/structural-neuroimaging-in-polysubstance-users
#4
COMMENT
Dieter J Meyerhoff
The simultaneous and/or concurrent use of licit and illicit substances (polysubstance use, PSU) is most common today. Structural magnetic resonance imaging (MRI) has been applied extensively to study individuals ostensibly using a single substance. These studies have produced a picture of regional gray matter and white matter alterations with each substance or class of substances. Very few studies measured regional brain morphometry in today's polysubstance users. This limited data suggest morphometric alterations with PSU that are not simply additive but often different from those of monosubstance users...
February 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/28091863/fast-progression-of-cerebellar-atrophy-in-pla2g6-associated-infantile-neuronal-axonal-dystrophy
#5
Mario Mascalchi, Francesco Mari, Beatrice Berti, Emanuele Bartolini, Matteo Lenge, Andrea Bianchi, Laura Antonucci, Filippo M Santorelli, Barbara Garavaglia, Renzo Guerrini
Infantile neuronal axonal dystrophy (INAD) is characterized by progressive cerebellar atrophy. MRI has been recommended as a marker of disease progression in cerebellar diseases. We performed a longitudinal brain volumetry study in a couple of bicorial twins with PLA2G6-positive INAD. Brain volumetry was calculated with FreeSurfer software on 3T T1-weighted images acquired at age 28 (t 0) and 36 months (t 1) in patient 1 and at age 22 (t 0) and 31 months (t 1) in patient 2. Data at t 0 were compared to those obtained in 18 control children aged 14-44 months with normal MRI...
January 14, 2017: Cerebellum
https://www.readbyqxmd.com/read/28091426/mri-based-detailed-evaluation-of-the-anatomy-of-the-human-coccyx-among-turkish-adults
#6
H Tetiker, M I Koşar, N Çullu, U Canbek, I Otağ, Y Taştemur
AIM: The human coccyx varies considerably in shape and size. The objective of this study was to investigate the morphology and morphometry of the coccyx on pelvic magnetic resonance imaging in asymptomatic individuals among Turkish adults. MATERIALS AND METHODS: This study was conducted retrospectively on the pelvic magnetic resonance images of 456 adult patients without a history of trauma in the coccyx region. The coccygeal vertebrae count, number of bone segments, and intercoccygeal and sacrococcygeal joint fusions were determined from the sagittal plane images...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28070745/considering-total-intracranial-volume-and-other-nuisance-variables-in-brain-voxel-based-morphometry-in-idiopathic-pd
#7
Samuel Crowley, Haiqing Huang, Jared Tanner, Qing Zho, Nadine A Schwab, Loren Hizel, Daniel Ramon, Babette Brumback, Mingzhou Ding, Catherine C Price
Voxel-based morphometry (VBM) studies of Parkinson's disease (PD), have yielded mixed results, possibly due to several studies not accounting for common nuisance variables (age, sex, and total intracranial volume [TICV]). TICV is particularly important because there is evidence for larger TICV in PD. We explored the influence of these covariates on VBM by 1) comparing PD patients and controls before adding covariates, after adding age and sex, and after adding age, sex and TICV, and 2) by comparing controls split into large and small TICV before and after controlling for TICV, with age and sex accounted for in both analyses...
January 9, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28032004/orbitofrontal-cortical-thinning-and-aggression-in-mild-traumatic-brain-injury-patients
#8
Daniel J Epstein, Margaret Legarreta, Elliot Bueler, Jace King, Erin McGlade, Deborah Yurgelun-Todd
INTRODUCTION: Although mild traumatic brain injury (mTBI) comprises 80% of all TBI, the morphological examination of the orbitofrontal cortex (OFC) in relation to clinical symptoms such as aggression, anxiety and depression in a strictly mTBI sample has never before been performed. OBJECTIVES: The primary objective of the study was to determine if mTBI patients would show morphological differences in the OFC and if the morphology of this region would relate to clinical symptoms...
December 2016: Brain and Behavior
https://www.readbyqxmd.com/read/28031996/structural-and-functional-neural-correlates-of-spatial-navigation-a-combined-voxel-based-morphometry-and-functional-connectivity-study
#9
Xin Hao, Yi Huang, Xueting Li, Yiying Song, Xiangzhen Kong, Xu Wang, Zetian Yang, Zonglei Zhen, Jia Liu
INTRODUCTION: Navigation is a fundamental and multidimensional cognitive function that individuals rely on to move around the environment. In this study, we investigated the neural basis of human spatial navigation ability. METHODS: A large cohort of participants (N > 200) was examined on their navigation ability behaviorally and structural and functional magnetic resonance imaging (MRI) were then used to explore the corresponding neural basis of spatial navigation...
December 2016: Brain and Behavior
https://www.readbyqxmd.com/read/28028623/cognitive-impairment-and-structural-brain-changes-in-patients-with-clinically-isolated-syndrome-at-high-risk-for-multiple-sclerosis
#10
Eva Hynčicová, Martin Vyhnálek, Adam Kalina, Lukáš Martinkovič, Tomáš Nikolai, Jiří Lisý, Jakub Hort, Eva Meluzínová, Jan Laczó
Patients with clinically isolated syndrome (CIS), unlike those with multiple sclerosis (MS), have a selective cognitive impairment which is not consistently related to structural brain changes. Our objective was to characterize a profile of cognitive impairment and its association with structural brain changes in patients with CIS who are at high risk of developing MS. Patients with CIS at high risk for MS on interferon-beta (n = 51) and age-, gender-, and education-matched controls (n = 44) underwent comprehensive neuropsychological testing and MRI brain scan with voxel-based morphometry...
December 27, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/28018854/cholinergic-depletion-and-basal-forebrain-volume-in-primary-progressive-aphasia
#11
Jolien Schaeverbeke, Charlotte Evenepoel, Rose Bruffaerts, Koen Van Laere, Guy Bormans, Eva Dries, Thomas Tousseyn, Natalie Nelissen, Ronald Peeters, Mathieu Vandenbulcke, Patrick Dupont, Rik Vandenberghe
Primary progressive aphasia (PPA) is a heterogeneous syndrome with various neuropathological causes for which no medical treatment with proven efficacy exists. Basal forebrain (BF) volume loss has been reported in PPA but its relation to cholinergic depletion is still unclear. The primary objective of this study was to investigate whether cholinergic alterations occur in PPA variants and how this relates to BF volume loss. An academic memory clinic based consecutive series of 11 PPA patients (five with the semantic variant (SV), four with the logopenic variant (LV) and two with the nonfluent variant (NFV)) participated in this cross-sectional in vivo PET imaging study together with 10 healthy control subjects...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28018194/cross-sectional-and-longitudinal-relationships-between-depressive-symptoms-and-brain-atrophy-in-ms-patients
#12
Heiner Stuke, Katrin Hanken, Jochen Hirsch, Jan Klein, Fabian Wittig, Andreas Kastrup, Helmut Hildebrandt
Introduction: Depressive symptoms are a frequent and distressing phenomenon in Multiple Sclerosis (MS) patients. Cross-sectional research links these symptoms to reduced brain gray matter volumes in parts of the prefrontal and temporal lobe as well as subcortical structures like the hippocampus, nucleus caudatus and globus pallidus. Nevertheless, prospective relationships between regional gray matter volume and the course of depressive symptoms are poorly understood. Methods: Forty-four patients with relapsing-remitting or secondary progressive MS participated in a prospective study with two assessments of depressive symptoms and high-resolution MRI with an inter-test-interval of 17 months...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28005183/altered-gray-matter-volume-in-stable-chronic-obstructive-pulmonary-disease-with-subclinical-cognitive-impairment-an-exploratory-study
#13
Chunrong Wang, Yanhui Ding, Bixian Shen, Dehong Gao, Jie An, Kewen Peng, Gangqiang Hou, Liqiu Zou, Mei Jiang, Shijun Qiu
Gray matter volume deficits have been identified in cognitively impaired patients with chronic obstructive pulmonary disease (COPD). However, it remains unknown whether the gray matter volume is altered in COPD patients with subclinical cognitive impairment. To determine whether any gray matter abnormalities are present in these patients, neuropsychological tests and structural MRI data were analyzed from 60 patients with COPD and 60 age-, gender-, education-, and handedness-matched normal controls (NCs). The COPD patients had similar Mini-Mental State Examination (MMSE) scores compared with the NCs...
December 22, 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27994534/influence-of-group-on-individual-subject-maps-in-spm-voxel-based-morphometry
#14
Andrew M Michael, Eli Evans, Gregory J Moore
Voxel based morphometry (VBM) is a widely utilized neuroimaging technique for spatially normalizing brain structural MRI (sMRI) onto a common template. The DARTEL technique of VBM takes into account the spatial intensity distribution of sMRIs to construct a study specific group template. The group template is then used to create final individual normalized tissue maps (FINTM) for each subject in the group. In this study, we investigate the effect of group on FINTM, i.e., we evaluate the variability of a constant subject's FINTM when other subjects in the group are iteratively changed...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27986606/imaging-the-neuroplastic-effects-of-ketamine-with-vbm-and-the-necessity-of-placebo-control
#15
A Höflich, S Ganger, M Tik, A Hahn, G S Kranz, T Vanicek, M Spies, C Kraus, C Windischberger, S Kasper, D Winkler, R Lanzenberger
In the last years a plethora of studies have investigated morphological changes induced by behavioural or pharmacological interventions using structural T1-weighted MRI and voxel-based morphometry (VBM). Ketamine is thought to exert its antidepressant action by restoring neuroplasticity. In order to test for acute impact of a single ketamine infusion on grey matter volume we performed a placebo-controlled, double-blind investigation in healthy volunteers using VBM. 28 healthy individuals underwent two MRI sessions within a timeframe of 2 weeks, each consisting of two structural T1-weighted MRIs within a single session, one before and one 45min after infusion of S-ketamine (bolus of 0...
December 13, 2016: NeuroImage
https://www.readbyqxmd.com/read/27981440/visceral-fat-is-associated-with-brain-structure-independent-of-human-immunodeficiency-virus-infection-status
#16
Jordan E Lake, Mikhail Popov, Wendy S Post, Frank J Palella, Ned Sacktor, Eric N Miller, Todd T Brown, James T Becker
The combined effects of human immunodeficiency virus (HIV), obesity, and elevated visceral adipose tissue (VAT) on brain structure are unknown. In a cross-sectional analysis of Multicenter AIDS Cohort Study (MACS) participants, we determined associations between HIV serostatus, adiposity, and brain structure. Men (133 HIV+, 84 HIV-) in the MACS Cardiovascular 2 and magnetic resonance imaging (MRI) sub-studies with CT-quantified VAT and whole brain MRI measured within 1 year were assessed. Voxel-based morphometry analyzed brain volumes...
December 15, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27973379/a-comparison-of-peripheral-imaging-technologies-for-bone-and-muscle-quantification-a-technical-review-of-image-acquisition
#17
A K Wong
The choice of an appropriate imaging technique to quantify bone, muscle, or muscle adiposity needs to be guided by a thorough understanding of its competitive advantages over other modalities balanced by its limitations. This review details the technical machinery and methods behind peripheral quantitative computed tomography (pQCT), high-resolution (HR)-pQCT, and magnetic resonance imaging (MRI) that drive successful depiction of bone and muscle morphometry, densitometry, and structure. It discusses a number of image acquisition settings, the challenges associated with using one versus another, and compares the risk-benefits across the different modalities...
December 14, 2016: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/27942451/neuroanatomical-correlates-of-prion-disease-progression-a-3t-longitudinal-voxel-based-morphometry-study
#18
Enrico De Vita, Gerard R Ridgway, Mark J White, Marie-Claire Porter, Diana Caine, Peter Rudge, John Collinge, Tarek A Yousry, Hans Rolf Jager, Simon Mead, John S Thornton, Harpreet Hyare
PURPOSE: MRI has become an essential tool for prion disease diagnosis. However there exist only a few serial MRI studies of prion patients, and these mostly used whole brain summary measures or region of interest based approaches. We present here the first longitudinal voxel-based morphometry (VBM) study in prion disease. The aim of this study was to systematically characterise progressive atrophy in patients with prion disease and identify whether atrophy in specific brain structures correlates with clinical assessment...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27942447/altered-structural-and-functional-thalamocortical-networks-in-secondarily-generalized-extratemporal-lobe-seizures
#19
Syu-Jyun Peng, Yue-Loong Hsin
Structural and functional abnormalities in the thalamocortical network in primary generalized epilepsies or mesial temporal lobe epilepsy have recently been identified by voxel-wise analyses of neuroimaging. However, evidence is needed regarding the profiles of the thalamocortical network in patients with secondarily generalized seizures from focal neocortical sources. We used high-resolution T1-weighted, diffusion-tensor and resting-state functional MR imaging (rs-fMRI) to examine 16 patients with secondarily generalized extratemporal lobe seizures and 16 healthy controls...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27941946/using-deep-belief-network-modelling-to-characterize-differences-in-brain-morphometry-in-schizophrenia
#20
Walter H L Pinaya, Ary Gadelha, Orla M Doyle, Cristiano Noto, André Zugman, Quirino Cordeiro, Andrea P Jackowski, Rodrigo A Bressan, João R Sato
Neuroimaging-based models contribute to increasing our understanding of schizophrenia pathophysiology and can reveal the underlying characteristics of this and other clinical conditions. However, the considerable variability in reported neuroimaging results mirrors the heterogeneity of the disorder. Machine learning methods capable of representing invariant features could circumvent this problem. In this structural MRI study, we trained a deep learning model known as deep belief network (DBN) to extract features from brain morphometry data and investigated its performance in discriminating between healthy controls (N = 83) and patients with schizophrenia (N = 143)...
December 12, 2016: Scientific Reports
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