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Morphometry MRI

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https://www.readbyqxmd.com/read/29338891/gray-and-white-matter-changes-and-their-relation-to-illness-trajectory-in-first-episode-psychosis
#1
Alejandro Keymer-Gausset, Anna Alonso-Solís, Iluminada Corripio, Rosa B Sauras-Quetcuti, Edith Pomarol-Clotet, Erick J Canales-Rodriguez, Eva Grasa-Bello, Enric Álvarez, Maria J Portella
Previous works have studied structural brain characteristics in first-episode psychosis (FEP), but few have focused on the relation between brain differences and illness trajectories. The aim of this study is to analyze gray and white matter changes in FEP patients and their relation with one-year clinical outcomes. A sample of 41 FEP patients and 41 healthy controls (HC), matched by age and educational level was scanned with a 3T MRI during the first month of illness onset. One year later, patients were assigned to two illness trajectories (schizophrenia and non-schizophrenia)...
January 12, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29335438/grey-and-white-matter-volumes-either-in-treatment-na%C3%A3-ve-or-hormone-treated-transgender-women-a-voxel-based-morphometry-study
#2
Giancarlo Spizzirri, Fábio Luis Souza Duran, Tiffany Moukbel Chaim-Avancini, Mauricio Henriques Serpa, Mikael Cavallet, Carla Maria Abreu Pereira, Pedro Paim Santos, Paula Squarzoni, Naomi Antunes da Costa, Geraldo F Busatto, Carmita Helena Najjar Abdo
Many previous magnetic resonance imaging (MRI) studies have documented sex differences in brain morphology, but the patterns of sexual brain differences in transgender women - male sex assigned at birth - with a diagnosis of gender dysphoria (TW) have been rarely investigated to date. We acquired T1-weighted MRI data for the following four (n = 80) groups: treatment-naïve TW (TNTW), TW treated with cross-sex hormones for at least one year (TTW), cisgender men, and cisgender women (cisgender individuals as controls)...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322264/cerebral-gray-matter-volume-in-patients-with-chronic-migraine-correlations-with-clinical-features
#3
Gianluca Coppola, Barbara Petolicchio, Antonio Di Renzo, Emanuele Tinelli, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Anna Ambrosini, Francesca Caramia, Vittorio Di Piero, Francesco Pierelli
BACKGROUND: To date, few MRI studies have been performed in patients affected by chronic migraine (CM), especially in those without medication overuse. Here, we performed magnetic resonance imaging (MRI) voxel-based morphometry (VBM) analyses to investigate the gray matter (GM) volume of the whole brain in patients affected by CM. Our aim was to investigate whether fluctuations in the GM volumes were related to the clinical features of CM. METHODS: Twenty untreated patients with CM without a past medical history of medication overuse underwent 3-Tesla MRI scans and were compared to a group of 20 healthy controls (HCs)...
December 8, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29321969/the-two-year-progression-of-structural-and-functional-cerebral-mri-in-amyotrophic-lateral-sclerosis
#4
R A L Menke, M Proudfoot, K Talbot, M R Turner
MRI has emerged as one of several urgently needed candidate disease progression biomarkers for the neurodegenerative disorder amyotrophic lateral sclerosis (ALS), not least due to its unique ability to non-invasively assess structural and functional cerebral pathology. We sought to identify the extent of detectable change in cerebral MRI metrics over a more prolonged period. Analysis of multi-modal MRI data was performed in a cohort of sixteen patients (13 ALS and 3 with primary lateral sclerosis) in whom it was possible to acquire six-monthly images over two years...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29321625/cerebellar-grey-matter-modifications-in-lower-limb-amputees-not-using-prosthesis
#5
Antonella Di Vita, Maddalena Boccia, Liana Palermo, Federico Nemmi, Marco Traballesi, Stefano Brunelli, Roberto De Giorgi, Gaspare Galati, Cecilia Guariglia
Plastic brain changes following peripheral deafferentation, in particular those following limb amputations, are well-documented, with significant reduction of grey matter (GM) in the sensory-motor cerebral areas representing the amputated limb. However, few studies have investigated the role played by the use of a prosthesis in these structural brain modifications. Here we hypothesized that using a functional prosthesis that allows individuals to perform actions may reduce grey matter reduction. We investigated the brain structural reorganization following lower limb amputation by using a Voxel Based Morphometry (VBM) analysis of structural magnetic resonance imaging (MRI) in 8 right-handed individuals with lower limb amputation (LLA) fitted with prostheses (LLAwp), compared to 6 LLA who had never used a prosthesis (LLAnp)...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320500/brain-structural-changes-in-cynomolgus-monkeys-administered-with-1-methyl-4-phenyl-1-2-3-6-tetrahydropyridine-a-longitudinal-voxel-based-morphometry-and-diffusion-tensor-imaging-study
#6
Hyeonseok S Jeong, Sang-Rae Lee, Jieun E Kim, In Kyoon Lyoo, Sujung Yoon, Eun Namgung, Kyu-Tae Chang, Bom Sahn Kim, Sejung Yang, Jooyeon J Im, Saerom Jeon, Ilhyang Kang, Jiyoung Ma, Yong-An Chung, Soo Mee Lim
In animal models of Parkinson's disease (PD), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is one of the most widely used agents that damages the nigrostriatal dopaminergic pathway. However, brain structural changes in response to MPTP remain unclear. This study aimed to investigate in vivo longitudinal changes in gray matter (GM) volume and white matter (WM) microstructure in primate models administered with MPTP. In six cynomolgus monkeys, high-resolution magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) scans were acquired 7 times over 32 weeks, and assessments of motor symptoms were conducted over 15 months, before and after the MPTP injection...
2018: PloS One
https://www.readbyqxmd.com/read/29301597/surface-based-morphometry-of-human-brain-intra-individual-comparison-between-3t-and-7t-high-resolution-structural-mr-imaging
#7
Zhiye Chen, Meng-Qi Liu, Lin Ma
ObjectiveHigh resolution structural MR imaging can reveal structural characteristics of cerebral cortex and provide an insight into normal brain development and neuropsychological diseases. The aim of this study was to compare cortical structural characteristics of normal human brain between 3T and 7T MRI systems using surface-based morphometry based on high resolution structural MR imaging. Methods Twelve healthy volunteers were scanned by both 3T with 3D T1-weighted fast spoiled gradient recalled echo (3D T1-FSPGR) sequence and 7T with 3D T1-weighted magnetization-prepared rapid gradient echo (3D T1-MPRAGE) sequence...
December 30, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29288983/automatic-spinal-cord-localization-robust-to-mri-contrasts-using-global-curve-optimization
#8
Charley Gros, Benjamin De Leener, Sara M Dupont, Allan R Martin, Michael G Fehlings, Rohit Bakshi, Subhash Tummala, Vincent Auclair, Donald G McLaren, Virginie Callot, Julien Cohen-Adad, Michaël Sdika
During the last two decades, MRI has been increasingly used for providing valuable quantitative information about spinal cord morphometry, such as quantification of the spinal cord atrophy in various diseases. However, despite the significant improvement of MR sequences adapted to the spinal cord, automatic image processing tools for spinal cord MRI data are not yet as developed as for the brain. There is nonetheless great interest in fully automatic and fast processing methods to be able to propose quantitative analysis pipelines on large datasets without user bias...
December 6, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29275588/-impairments-of-gray-matter-in-mri-negative-epileptic-patients-with-different-seizure-types
#9
W Quan, Q Xu, F Yang, G H Chen, Z X Lin, Q R Zhang, J H Xiao, G M Lu, Z Q Zhang
Objective: To investigate the damage of gray matter structure in MRI-negative epilepsy patients with different symptoms by voxel-based morphometry (VBM). Methods: From June, 2009 to October, 2016, ninety MRI-negative epilepsy patients and thirty-five healthy volunteers underwent the 3T magnetic resonance imaging scan in Nanjing General Hospital. The patients were divided into three groups, including idiopathic generalized tonic-clonic seizure (I-GTCS), secondarily generalized tonic-clonic seizure (S-GTCS), and partial seizure (PS) according to different symptoms...
December 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29274430/divergent-brain-changes-in-two-audiogenic-rat-strains-a-voxel-based-morphometry-and-diffusion-tensor-imaging-comparison-of-the-genetically-epilepsy-prone-rat-gepr-3-and-the-wistar-audiogenic-rat-war
#10
Yichien Lee, Olga C Rodriguez, Chris Albanese, Victor Rodrigues Santos, José Antônio Cortes de Oliveira, Ana Luiza Ferreira Donatti, Artur Fernandes, Norberto Garcia-Cairasco, Prosper N'Gouemo, Patrick A Forcelli
Acoustically evoked seizures (e.g., audiogenic seizures or AGS) are common in models of inherited epilepsy and occur in a variety of species including rat, mouse, and hamster. Two models that have been particularly well studied are the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR) strains. Acute and repeated AGS, as well as comorbid conditions, displays a close phenotypic overlap in these models. Whether these similarities arise from convergent or divergent structural changes in the brain remains unknown...
December 20, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29249808/brain-structure-in-women-at-risk-of-postpartum-psychosis-an-mri-study
#11
Montserrat Fusté, Astrid Pauls, Amanda Worker, Antje A T S Reinders, Andrew Simmons, Steven C R Williams, Josep M Haro, Kate Hazelgrove, Susan Pawlby, Susan Conroy, Costanza Vecchio, Gertrude Seneviratne, Carmine M Pariante, Mitul A Mehta, Paola Dazzan
Postpartum psychosis (PP) is the most severe psychiatric disorder associated with childbirth. The risk of PP is very high in women with a history of bipolar affective disorder or schizoaffective disorder. However, the neurobiological basis of PP remains poorly understood and no study has evaluated brain structure in women at risk of, or with, PP. We performed a cross-sectional study of 256 women at risk of PP and 21 healthy controls (HC) in the same postpartum period. Among women at risk, 11 who developed a recent episode of PP (PPE) (n = 2 with lifetime bipolar disorder; n = 9 psychotic disorder not otherwise specified) and 15 at risk women who did not develop an episode of PP (NPPE) (n = 10 with lifetime bipolar disorder; n = 1 with schizoaffective disorder; n = 1 with a history of PP in first-degree family member; n = 3 with previous PP)...
December 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29244231/differences-in-regional-grey-matter-volumes-in-currently-ill-patients-with-anorexia-nervosa
#12
Andrea Phillipou, Susan Lee Rossell, Caroline Gurvich, David Jonathan Castle, Larry Allen Abel, Richard Grant Nibbs, Matthew Edward Hughes
Neurobiological findings in anorexia nervosa (AN) are inconsistent, including differences in regional grey matter volumes. Methodological limitations often contribute to the inconsistencies reported. The aim of this study was to improve on these methodologies by utilising voxel based morphometry (VBM) analysis with the use of diffeomorphic anatomic registration through an exponentiated lie algebra algorithm (DARTEL), in a relatively large group of individuals with AN. Twenty-six individuals with AN and 27 healthy controls underwent a T1-weighted magnetic resonance imaging (MRI) scan...
December 15, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29236647/assessing-the-marks-of-change-how-psychotherapy-alters-the-brain-structure-in-women-with-borderline-personality-disorder
#13
Falk Mancke, Ruth Schmitt, Dorina Winter, Inga Niedtfeld, Sabine C Herpertz, Christian Schmahl
BACKGROUND: There is increasing evidence that psychotherapy can alter the function of the brain of patients with borderline personality disorder (BPD). However, it is not known whether psychotherapy can also modify the brain structure of patients with BPD. METHODS: We used structural MRI data of female patients with BPD before and after participation in 12 weeks of residential dialectical behavioural therapy (DBT) and compared them to data from female patients with BPD who received treatment as usual (TAU)...
December 13, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29235194/dual-sensitivity-multiple-sclerosis-lesion-and-csf-segmentation-for-multichannel-3t-brain-mri
#14
Dominik S Meier, Charles R G Guttmann, Subhash Tummala, Nicola Moscufo, Michele Cavallari, Shahamat Tauhid, Rohit Bakshi, Howard L Weiner
BACKGROUND AND PURPOSE: A pipeline for fully automated segmentation of 3T brain MRI scans in multiple sclerosis (MS) is presented. This 3T morphometry (3TM) pipeline provides indicators of MS disease progression from multichannel datasets with high-resolution 3-dimensional T1-weighted, T2-weighted, and fluid-attenuated inversion-recovery (FLAIR) contrast. 3TM segments white (WM) and gray matter (GM) and cerebrospinal fluid (CSF) to assess atrophy and provides WM lesion (WML) volume. METHODS: To address nonuniform distribution of noise/contrast (eg, posterior fossa in 3D-FLAIR) of 3T magnetic resonance imaging, the method employs dual sensitivity (different sensitivities for lesion detection in predefined regions)...
December 13, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29230507/evidence-for-regional-hippocampal-damage-in-patients-with-schizophrenia
#15
Sadhana Singh, Subash Khushu, Pawan Kumar, Satnam Goyal, Triptish Bhatia, Smita N Deshpande
PURPOSE: Schizophrenia patients show cognitive and mood impairments, including memory loss and depression, suggesting damage in the brain regions. The hippocampus is a brain structure that is significantly involved in memory and mood function and shows impairment in schizophrenia. In the present study, we examined the regional hippocampal changes in schizophrenia patients using voxel-based morphometry (VBM), Freesurfer, and proton magnetic resonance spectroscopy (1H MRS) procedures. METHODS: 1H MRS and high-resolution T1-weighted magnetic resonance imaging were collected in both healthy control subjects (N = 28) and schizophrenia patients (N = 28) using 3-Tesla whole body MRI system...
December 11, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29225356/quantitative-neurobiological-evidence-for-accelerated-brain-aging-in-alcohol-dependence
#16
Matthias Guggenmos, Katharina Schmack, Maria Sekutowicz, Maria Garbusow, Miriam Sebold, Christian Sommer, Michael N Smolka, Hans-Ulrich Wittchen, Ulrich S Zimmermann, Andreas Heinz, Philipp Sterzer
The premature aging hypothesis of alcohol dependence proposes that the neurobiological and behavioural deficits in individuals with alcohol dependence are analogous to those of chronological aging. However, to date no systematic neurobiological evidence for this hypothesis has been provided. To test the hypothesis, 119 alcohol-dependent subjects and 97 age- and gender-matched healthy control subjects underwent structural MRI. Whole-brain grey matter volume maps were computed from structural MRI scans using voxel-based morphometry and parcelled into a comprehensive set of anatomical brain regions...
December 11, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29223329/the-impact-of-psychosis-on-brain-anatomy-in-bipolar-disorder-a-structural-mri-study
#17
A Carlo Altamura, Eleonora Maggioni, Taj Dhanoa, Valentina Ciappolino, Riccardo A Paoli, Laura Cremaschi, Cecilia Prunas, Giulia Orsenigo, Elisabetta Caletti, Claudia M Cinnante, Fabio M Triulzi, Bernardo Dell'Osso, Lakshmi Yatham, Paolo Brambilla
BACKGROUND: Bipolar disorder (BD) is a major psychiatric illness characterized by heterogeneous symptoms including psychotic features. Up until now, neuroimaging studies investigating cerebral morphology in patients with BD have underestimated the potential impact of psychosis on brain anatomy in BD patients. In this regard, psychotic and non-psychotic BD may represent biologically different subtypes of the disorder, being possibly associated with specific cerebral features. METHODS: In the present study, magnetic resonance imaging (MRI) at 3T was used to identify the neuroanatomical correlates of psychosis in an International sample of BD patients...
November 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29214796/grey-matter-correlates-of-autistic-traits-in-women-with-anorexia-nervosa
#18
Malin Björnsdotter, Monika Davidovic, Louise Karjalainen, Göran Starck, Håkan Olausson, Elisabet Wentz
Background: Patients with anorexia nervosa exhibit higher levels of behaviours typically associated with autism-spectrum disorder (ASD), but the neural basis is unclear. We sought to determine whether elevated autistic traits in women with anorexia nervosa may be reflected in cortical morphology. Methods: We used voxel-based morphometry (VBM) to examine regional grey matter volumes in high-resolution MRI structural brain scans in women with anorexia nervosa and matched healthy controls...
December 7, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29210075/noise-contamination-from-pet-blood-sampling-pump-effects-on-structural-mri-image-quality-in-simultaneous-pet-mr-studies
#19
Elizabeth Bartlett, Christine DeLorenzo, Ramin Parsey, Chuan Huang
PURPOSE: To fully quantify PET imaging outcome measures, a blood-sampling pump is often used during the PET acquisition. With simultaneous PET/MR studies, a structural magnetization-prepared rapid gradient-echo (MP-RAGE) may also be acquired while the pump is generating electromagnetic noise. This study investigated whether this noise contamination would be detrimental to the quantification of volume and cortical thickness measures obtained from automated segmentation of the MP-RAGE image...
December 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/29209922/altered-brain-morphometry-in-7-year-old-hiv-infected-children-on-early-art
#20
Emmanuel C Nwosu, Frances C Robertson, Martha J Holmes, Mark F Cotton, Els Dobbels, Francesca Little, Barbara Laughton, Andre van der Kouwe, Ernesta M Meintjes
Even with the increased roll out of combination antiretroviral therapy (cART), paediatric HIV infection is associated with neurodevelopmental delays and neurocognitive deficits that may be accompanied by alterations in brain structure. Few neuroimaging studies have been done in children initiating ART before 2 years of age, and even fewer in children within the critical stage of brain development between 5 and 11 years. We hypothesized that early ART would limit HIV-related brain morphometric deficits at age 7...
December 5, 2017: Metabolic Brain Disease
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