Read by QxMD icon Read

Over active bladder

Karl Patterson, Lovleen Arya, Sarah Bottomley, Susan Morgan, Angela Cox, James Catto, Helen E Bryant
RECQ helicases are a family of enzymes with both over lapping and unique functions. Functional autosomal recessive loss of three members of the family BLM, WRN and RECQL4, results in hereditary human syndromes characterized by cancer predisposition and premature aging, but despite the finding that RECQL5 deficient mice are cancer prone, no such link has been made to human RECQL5. Here we demonstrate that human urothelial carcinoma of the bladder (UCC) has increased expression of RECQL5 compared to normal bladder tissue and that increasing RECQL5 expression can drive proliferation of normal bladder cells and is associated with poor prognosis...
October 15, 2016: Oncotarget
Pawel Miotla, Rufus Cartwright, Katarzyna Skorupska, Michal Bogusiewicz, Ewa Markut-Miotla, Konrad Futyma, Tomasz Rechberger
AIMS: Urgency urinary incontinence (UUI), and the symptoms of overactive bladder (OAB) have a negative impact on female sexual function. The aim of this study was to investigate the effect of intravesical onabotulinumtoxinA (Botox) injection on sexual function in women with OAB, using the multi domain Female Sexual Function Index (FSFI) questionnaire. METHODS: Sixty-eight sexually active women with idiopathic OAB with at least one episode of UUI and ≥8 micturitions per 24 h were recruited...
October 4, 2016: Neurourology and Urodynamics
Catherine Montaut, Xavier Gamé, Xavier de Boissezon, Philippe Marque, Evelyne Castel-Lacanal
OBJECTIVE: Lower urinary tract dysfunctions (LUTD) are very common in neurological diseases. TENS is a therapeutic alternative in the treatment of urinary and pelvic perineal symptoms, whose effectiveness has been proven in multiple sclerosis. Evaluate the benefits of treatment with TENS (U3 program) in clinical practice for neurological lower urinary tract dysfunctions (LUTD), incompletely controlled by the usual pharmacological treatment, on urinary symptoms and quality of life. MATERIALS/PATIENTS AND METHODS: We performed a cohort, and prospective study, between June 2014 and September 2015 in the Physical Medicine and Rehabilitation Service in CHU Toulouse, Rangueil...
September 2016: Annals of Physical and Rehabilitation Medicine
Pradeep K Garg, Stephen J Lokitz, Rachid Nazih, Sudha Garg
: The main focus of this study was to assess the in vivo distribution and radiation absorbed dose of (11)C-nicotine derived from the whole body Positron emission tomography (PET) imaging in humans. METHODS: After an initial Computed tomography (CT) attenuation scan, (11)C-nicotine was administered via an intravenous injection, and dynamic whole body PET scans were acquired in a 3-D mode on 11 normal healthy (5 male, 6 female) subjects. The first scan was acquired in a dynamic acquisition mode for 90 s with the brain in the field of view, followed by a series of whole body PET scans acquired over a 90 min time period...
September 22, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Amy Pan, Hongyong Zhang, Yuanpei Li, Tzu-Yin Lin, Fuli Wang, Joyce Lee, Mingshan Cheng, Marc Dall'Era, Tianhong Li, Ralph deVere White, Chong-Xian Pan, Kit S Lam
Chemotherapy commonly used in the treatment of advanced bladder cancer is only moderately effective and associated with significant toxicity. There has been no appreciable improvement in overall survival over the last three decades. The goal of this project is to develop and characterize bladder cancer-specific nanometer-scale micelles loaded with the chemotherapeutic drug paclitaxel (PTX) and determine the anti-tumor activity and toxicity. Micelle-building-material telodendrimers were synthesized through the stepwise conjugation of eight cholic acid units at one terminus of polyethylene glycol (PEG) and a bladder cancer-specific targeting peptide named PLZ4 at the other terminus...
October 21, 2016: Nanotechnology
H M Golder, N Moss, G Rogers, B Jackson, N Gannon, Ptw Wong, I J Lean
CASE HISTORY: A herd of Holstein, Jersey, or Holstein-Jersey cross lactating cattle of mixed ages presented with a sudden drop in milk yield in 94/678 cows on 3 October 2014 (Day 0). The herd was located in Gretna in the Derwent Valley (Tasmania, Australia) and had been grazing dryland pasture. CLINICAL FINDINGS: On Day 0 the cows variably showed recumbency, peracute photosensitisation, inflamed coronary bands, conjunctival erythema, periauricular oedema, distress indicated by kicking at the flank, bruxism, discomfort, weight shifting, vocalisation indicating pain and depression...
October 2, 2016: New Zealand Veterinary Journal
Michael E Hurwitz, Joseph Sokhn, Daniel P Petrylak
PURPOSE OF REVIEW: Over the last 10 years, harnessing of the immune system to attack tumors has been one of the major breakthroughs in cancer, primarily through the use of immune checkpoint inhibitors (ICIs). This review will summarize current immune treatments in urologic malignancies and ongoing trials with novel combinations and in different disease settings. RECENT FINDINGS: Patients with urologic malignancies such as kidney and bladder cancer have benefited significantly from these advances with the approval of ICIs in both of these diseases...
November 2016: Current Opinion in Urology
Burak Akselim, Melike Doğanay, Nilay Özcan, Sinem Akselim, Sabri Cavkaytar
INTRODUCTION AND HYPOTHESIS: The aim of the study was to investigate the correlation between mean bladder wall thickness (BWT) and treatment success in patients diagnosed with urinary incontinence, based on urodynamic test results. METHODS: In this prospective study, patient urinary incontinence type was identified using urodynamic tests. Patients (N = 125) were categorized into three groups: urodynamic stress incontinence (SUI), detrusor over-activity (DO) and mixed urinary incontinence...
August 22, 2016: International Urogynecology Journal
A Antoniou, J Mendez Rodrigues, N Comi
We report a rare case of Myasthenia gravis and overactive bladder successfully treated with pretibial nerve stimulation.
August 2016: JRSM Open
Wei-Cheng Tseng, Cheng-Wei Chuang, Muh-Hwa Yang, Chin-Chen Pan, Der-Cherng Tarng
BACKGROUND: Krüppel-like factor 4 (KLF4) exerts tumor suppressive or oncogenic functions in a cell-type-dependent manner, but its prognostic role in urothelial carcinoma of bladder (UCB) remains unclear. We aimed to determine how KLF4 regulates epithelial-mesenchymal transition (EMT) and predicts patient survival in UCB. PATIENTS AND METHODS: The roles of KLF4 and other EMT regulators in cancer progression were studied in UCB specimens of 398 patients, UCB cell lines...
August 9, 2016: Urologic Oncology
Rahil Ghanavati, Foroogh Namjoyan, Hosein Rezaee Zadeh
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS) and is the most common cause of neurologic disability in young adults (20-40 years old). About 2.5 million patients all over the world are suffering from MS. Common symptoms of the disease include sensory disorders, optic neuritis, and limb weakness. Following disease progression, other symptoms like fatigue, bladder disorders, and cognitive impairment also occur. Traditional Persian medicine (TPM) is an ancient medical system from 6000 years ago in Persia, where Iran was its most important state...
May 2016: Iranian Journal of Medical Sciences
Anbang He, Yuchen Liu, Zhicong Chen, Jianfa Li, Mingwei Chen, Li Liu, Xinhui Liao, Zhaojie Lv, Yonghao Zhan, Chengle Zhuang, Junhao Lin, Weiren Huang, Hongbing Mei
BACKGROUND: Accumulating evidences indicated that lncRNAs play crucial regulatory roles in oncogenesis and progression of cancers. BRAF activated non-coding RNA (BANCR) has been identified to contribute to the progression of some human cancers. However, the relationship between BANCR and bladder cancer (BC) is largely unclear. METHODS: BANCR expression levels in BC, paired non-cancer tissues and BC cell lines were detected by real-time quantitative RT-PCR (qRT-PCR)...
2016: Journal of Experimental & Clinical Cancer Research: CR
Seung-Shick Shin, Sung-Soo Park, Byungdoo Hwang, Won Tae Kim, Yung Hyun Choi, Wun-Jae Kim, Sung-Kwon Moon
Despite the clinical significance of tumorigenesis, little is known about the cellular signaling networks of microRNAs (miRs). Here we report a new finding that mir‑106a regulates the proliferation, migration, and invasion of bladder cancer cells. Basal expression levels of mir‑106a were significantly lower in bladder cancer cells than in normal urothelial cells. Overexpression of mir‑106a suppressed the proliferation of bladder cancer cell line EJ. Transient transfection of mir‑106a into EJ cells led to downregulation of ERK phosphorylation and upregulation of p38 and JNK phosphorylation over their levels in the control...
October 2016: Oncology Reports
Yu-Min Lin, Bu-Chin Yu, Wen-Tai Chiu, Hung-Yu Sun, Yu-Chieh Chien, Hui-Chen Su, Shu-Yang Yen, Hsin-Wen Lai, Chyi-Huey Bai, Kung-Chia Young, Chiung-Wen Tsao
Fluoxetine, a well-known anti-depression agent, may act as a chemosensitizer to assist and promote cancer therapy. However, how fluoxetine regulates cellular signaling to enhance cellular responses against tumor cell growth remains unclear. In the present study, addition of fluoxetine promoted growth inhibition of interferon-alpha (IFN-α) in human bladder carcinoma cells but not in normal uroepithelial cells through lessening the IFN-α-induced apoptosis but switching to cause G1 arrest, and maintaining the IFN-α-mediated reduction in G2/M phase...
October 2016: International Journal of Oncology
Amy Miller, Hannah Burson, Ariane Söling, Johnny Roughan
Few studies have assessed whether mice used as cancer models experience pain. Despite this possibility, the usual practice is to withhold analgesics as these are generally viewed as confounding. However, pain also alters cancer progression, so preventing it might not only be beneficial to welfare but also to study validity. Establishing the extent to which different cancer models result in pain is an important first step towards their refinement. We used conditioned place preference (CPP) testing and body-weight and behaviour analyses to evaluate the assumption that heterotopically implanted tumours result in less pain and fewer welfare concerns than those implanted orthotopically...
2016: PloS One
Tripti Mishra, Rakesh Kumar Arya, Sanjeev Meena, Pushpa Joshi, Mahesh Pal, Baleshwar Meena, D K Upreti, T S Rana, Dipak Datta
Betula utilis, also known as Himalayan silver birch has been used as a traditional medicine for many health ailments like inflammatation, HIV, renal and bladder disorders as well as many cancers from ages. Here, we performed bio-guided fractionation of Betula utilis Bark (BUB), in which it was extracted in methanol and fractionated with hexane, ethyl acetate, chloroform, n-butanol and water. All six fractions were evaluated for their in-vitro anticancer activity in nine different cancer cell lines and ethyl acetate fraction was found to be one of the most potent fractions in terms of inducing cytotoxic activity against various cancer cell lines...
2016: PloS One
Marcus J Drake, Anthony Kanai, Dominika A Bijos, Youko Ikeda, Irina Zabbarova, Bahareh Vahabi, Christopher H Fry
The isolated bladder shows autonomous micromotions, which increase with bladder distension, generate sensory nerve activity, and are altered in models of urinary dysfunction. Intravesical pressure resulting from autonomous activity putatively reflects three key variables; the extent of micromotion initiation, distances over which micromotions propagate, and overall bladder tone. In vivo, these variables are subordinate to the efferent drive of the central nervous system. In the micturition cycle storage phase, efferent inhibition keeps autonomous activity generally at a low level, where it may signal 'state of fullness', whilst maintaining compliance...
July 22, 2016: BJU International
P van der Meer, M W M Post, C M C van Leeuwen, H J M van Kuppevelt, C A J Smit, F W A van Asbeck
STUDY DESIGN: This is a multicenter prospective cohort study. OBJECTIVES: The objective of this study was to describe and compare the impact of health problems secondary to spinal cord injury (SCI) on functioning at home and on social activities at 1 and 5 years after discharge from first inpatient rehabilitation. SETTING: The study was conducted in a Dutch community. METHODS: Participants with SCI who use a wheelchair for everyday mobility (N=110) completed a self-report questionnaire as part of a larger cohort study including four items on extra time needed (body care, bladder and bowel regulation, 'organization' and transportation) and impact of 10 health problems on functioning at home and on social activities...
July 19, 2016: Spinal Cord
Ciorsdan A Campion, Declan Soden, Patrick F Forde
BACKGROUND: The ever increasing knowledge in the areas of cell biology, the immune system and the mechanisms of cancer are allowing a new phase of immunotherapy to develop. The aim of cancer vaccination is to activate the host immune system and some success has been observed particularly in the use of the BCG vaccine for bladder cancer as an immunostimulant. Reovirus, an orphan virus, has proven itself as an oncolytic virus in vitro and in vivo. Over 80 % of tumour cell lines have been found to be susceptible to Reovirus infection and it is currently in phase III clinical trials...
2016: BMC Cancer
Leonel E Medina, Warren M Grill
BACKGROUND: Incorporating kilohertz-frequency signals in transcutaneous electrical stimulation has been proposed as a means to overcome the impedance of the skin, thereby reaching deeper nerves. In particular, a transdermal amplitude modulated signal (TAMS), composed of a 210 kHz non-zero offset carrier modulated by rectangular pulses, was introduced recently for the treatment of overactive bladder. However, the contribution of the components of TAMS to nerve fiber activation has not been quantified...
2016: Journal of Neuroengineering and Rehabilitation
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"