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https://www.readbyqxmd.com/read/27921319/critical-evaluation-of-the-overactive-bladder-and-urgency-urinary-incontinence-association-with-obstructive-sleep-apnea-syndrome-in-a-relatively-young-adult-male-population
#1
Murat Tuncer, Ozgur Yazici, Alper Kafkasli, Kubilay Sabuncu, Banu Salepci, Fehmi Narter, Gulten A Gungor, Ugur Yucetas
AIMS: To evaluate the prevalence of Overactive Bladder (OAB) and Urgency Urinary Incontinence (UUI) in males with Obstructive Sleep Apnea Syndrome (OSAS) using the OSAS grading system. METHODS: A total of 194 patients who underwent Polysomnography (PSG) were included in our prospective cross sectional study. Patients were divided into four groups according to Apnea-Hypopnea Index (AHI). Group 1, 35 patients with normal AHI (<5) as a control group; Group 2, 47 patients with mild OSAS (AHI ≥5 and <15); Group 3, 51 patients with moderate OSAS (AHI ≥15 and <30); Group 4, 61 patients with severe OSAS (AHI ≥30)...
December 6, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27914585/bladder-augmentation-in-anuric-defunctioned-microbladders-and-a-novel-antireflux-mechanism-for-mitrofanoff-anastomosis-to-the-ileal-patch
#2
Joana Lopes, Andy Robb, Liam McCarthy
BACKGROUND/PURPOSE: Reconstruction of microbladders is a difficult surgical challenge: How can a neobladder be recreated when >90% of the new bladder is augmented patch, and how can a Mitrofanoff conduit be anastomosed when the native bladder is so tiny? This series describes microbladders secondary to anuria and/or diversion that required augmentation. This was done using a de-tubularized ileal segment, and because of the small size of the native bladder, Mitrofanoff anastomosis was performed to the bowel patch (using a novel "Keel Procedure")...
November 13, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27871929/past-present-and-future-of-chemodenervation-with-botulinum-toxin-in-the-treatment-of-oab
#3
Pradeep Tyagi, Mahendra Kashyap, Naoki Yoshimura, Michael Chancellor, Christopher J Chermansky
PURPOSE: We systematically reviewed both pre-clinical and clinical studies on bladder chemodenervation with onabotulinumtoxin A to highlight current limitations and future drug delivery approaches. MATERIALS AND METHODS: We identified peer-reviewed basic and clinical research studies of onabotulinumtoxin A (onaBoNT-A) in the treatment of neurogenic bladder and refractory idiopathic overactive bladder (OAB) published between March 2000 and March 2016. Paired investigators independently screened 125 English language articles to identify controlled studies on onaBoNT-A administration in MEDLINE® database and abstracts presented at annual American Urological Association meetings...
November 18, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27868230/no-immediate-effect-on-urodynamic-parameters-during-transcutaneous-electrical-nerve-stimulation-tens-in-children-with-overactive-bladder-and-daytime-incontinence-a-randomized-double-blind-placebo-controlled-study
#4
Luise Borch, Soeren Rittig, Konstantinos Kamperis, Birgitte Mahler, Jens Christian Djurhuus, Soeren Hagstroem
AIM: To evaluate the immediate effect on natural fill urodynamic parameters and bladder function during transcutaneous electrical nerve stimulation (TENS) in children with overactive bladder (OAB) and daytime urinary incontinence (DUI). METHODS: In this double-blind, placebo-controlled study, 24 children with severe OAB and DUI (mean age 8.5 ± 1.2 years) underwent 48-h natural fill urodynamics. After 24 h of baseline investigation, the children were randomized to either active continuous TENS (n = 12) or placebo TENS (n = 12) over the sacral S2-S3 outflow...
November 21, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27865751/feasibility-of-long-term-tibial-nerve-stimulation-using-a-multi-contact-and-wirelessly-powered-neurostimulation-system-implanted-in-rats
#5
Zainab Moazzam, Jason Paquette, Austin R Duke, Navid Khodaparast, Paul B Yoo
OBJECTIVES: Implant-driven tibial nerve stimulation (TNS) therapy is an effective technique for treating overactive bladder (OAB). However, the monopolar lead design in the currently available implantable devices pose long-term therapeutic challenges in terms of efficiently and selectively delivering electrical pulses to the target. Hence, the purpose of this study was to: (1) characterize the tibial nerve (TN) activation properties using a multi-contact implantable system and (2) evaluate the long-term stability of using such a neural interface in a pre-clinical model...
November 16, 2016: Urology
https://www.readbyqxmd.com/read/27846884/future-perspectives-in-melanoma-research-meeting-report-from-the-melanoma-bridge-napoli-december-1st-4th-2015
#6
Paolo A Ascierto, Sanjiv Agarwala, Gerardo Botti, Alessandra Cesano, Gennaro Ciliberto, Michael A Davies, Sandra Demaria, Reinhard Dummer, Alexander M Eggermont, Soldano Ferrone, Yang Xin Fu, Thomas F Gajewski, Claus Garbe, Veronica Huber, Samir Khleif, Michael Krauthammer, Roger S Lo, Giuseppe Masucci, Giuseppe Palmieri, Michael Postow, Igor Puzanov, Ann Silk, Stefani Spranger, David F Stroncek, Ahmad Tarhini, Janis M Taube, Alessandro Testori, Ena Wang, Jennifer A Wargo, Cassian Yee, Hassane Zarour, Laurence Zitvogel, Bernard A Fox, Nicola Mozzillo, Francesco M Marincola, Magdalena Thurin
The sixth "Melanoma Bridge Meeting" took place in Naples, Italy, December 1st-4th, 2015. The four sessions at this meeting were focused on: (1) molecular and immune advances; (2) combination therapies; (3) news in immunotherapy; and 4) tumor microenvironment and biomarkers. Recent advances in tumor biology and immunology has led to the development of new targeted and immunotherapeutic agents that prolong progression-free survival (PFS) and overall survival (OS) of cancer patients. Immunotherapies in particular have emerged as highly successful approaches to treat patients with cancer including melanoma, non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), bladder cancer, and Hodgkin's disease...
November 15, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27813450/exploring-daily-blood-pressure-fluctuations-and-cardiovascular-risk-among-individuals-with-motor-complete-spinal-cord-injury-a-pilot-study
#7
Derry L Dance, Amit Chopra, Kent Campbell, David S Ditor, Magdy Hassouna, B Catharine Craven
BACKGROUND: Clinically silent autonomic dysfunction with bowel and bladder care, are postulated to contribute to cardiovascular disease after chronic spinal cord injury (SCI). OBJECTIVE: We describe the frequency and severity of dysreflexic episodes, termed transient blood pressure elevations (T-BPE) over 48 hours in adults with cervical or high-thoracic motor-complete SCI. SETTING: Tertiary SCI Rehabilitation Centre in Toronto, Canada. PARTICIPANTS: Individuals with chronic SCI, C1-T3 AIS A or B, >1 year post-injury, living in the community (n=19)...
November 4, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27798422/epidural-and-transcutaneous-spinal-electrical-stimulation-for-restoration-of-movement-after-incomplete-and-complete-spinal-cord-injury
#8
Winfried Mayr, Matthias Krenn, Milan R Dimitrijevic
PURPOSE OF REVIEW: The Purpose of this review is to outline and explain the therapeutic use of electrical spinal cord stimulation (SCS) for modification of spinal motor output. Central functional stimulation provides afferent input to posterior root neurons and is applied to improve volitional movements, posture and their endurance, control spasticity, and improve bladder function or perfusion in the lower limbs. Clinical accomplishments strongly depend on each individual's physiological state and specific methodical adaptation to that physiological state...
December 2016: Current Opinion in Neurology
https://www.readbyqxmd.com/read/27764811/altered-recql5-expression-in-urothelial-bladder-carcinoma-increases-cellular-proliferation-and-makes-recql5-helicase-activity-a-novel-target-for-chemotherapy
#9
Karl Patterson, Lovleen Arya, Sarah Bottomley, Susan Morgan, Angela Cox, James Catto, Helen E Bryant
RECQ helicases are a family of enzymes with both over lapping and unique functions. Functional autosomal recessive loss of three members of the family BLM, WRN and RECQL4, results in hereditary human syndromes characterized by cancer predisposition and premature aging, but despite the finding that RECQL5 deficient mice are cancer prone, no such link has been made to human RECQL5. Here we demonstrate that human urothelial carcinoma of the bladder (UCC) has increased expression of RECQL5 compared to normal bladder tissue and that increasing RECQL5 expression can drive proliferation of normal bladder cells and is associated with poor prognosis...
October 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27701762/impact-of-intravesical-onabotulinumtoxina-on-sexual-function-in-women-with-oab
#10
Pawel Miotla, Rufus Cartwright, Katarzyna Skorupska, Michal Bogusiewicz, Ewa Markut-Miotla, Konrad Futyma, Tomasz Rechberger
AIMS: Urgency urinary incontinence (UUI), and the symptoms of overactive bladder (OAB) have a negative impact on female sexual function. The aim of this study was to investigate the effect of intravesical onabotulinumtoxinA (Botox) injection on sexual function in women with OAB, using the multi domain Female Sexual Function Index (FSFI) questionnaire. METHODS: Sixty-eight sexually active women with idiopathic OAB with at least one episode of UUI and ≥8 micturitions per 24 h were recruited...
October 4, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27676713/evaluation-of-the-benefits-of-treatment-with-tens-for-neurological-lower-urinary-tract-dysfunctions
#11
Catherine Montaut, Xavier Gamé, Xavier de Boissezon, Philippe Marque, Evelyne Castel-Lacanal
OBJECTIVE: Lower urinary tract dysfunctions (LUTD) are very common in neurological diseases. TENS is a therapeutic alternative in the treatment of urinary and pelvic perineal symptoms, whose effectiveness has been proven in multiple sclerosis. Evaluate the benefits of treatment with TENS (U3 program) in clinical practice for neurological lower urinary tract dysfunctions (LUTD), incompletely controlled by the usual pharmacological treatment, on urinary symptoms and quality of life. MATERIALS/PATIENTS AND METHODS: We performed a cohort, and prospective study, between June 2014 and September 2015 in the Physical Medicine and Rehabilitation Service in CHU Toulouse, Rangueil...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27660145/biodistribution-and-radiation-dosimetry-of-c-11-nicotine-from-whole-body-pet-imaging-in-humans
#12
Pradeep K Garg, Stephen J Lokitz, Rachid Nazih, Sudha Garg
: The main focus of this study was to assess the in vivo distribution and radiation absorbed dose of (11)C-nicotine derived from the whole body Positron emission tomography (PET) imaging in humans. METHODS: After an initial Computed tomography (CT) attenuation scan, (11)C-nicotine was administered via an intravenous injection, and dynamic whole body PET scans were acquired in a 3-D mode on 11 normal healthy (5 male, 6 female) subjects. The first scan was acquired in a dynamic acquisition mode for 90 s with the brain in the field of view, followed by a series of whole body PET scans acquired over a 90 min time period...
September 22, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27640312/disulfide-crosslinked-nanomicelles-confer-cancer-specific-drug-delivery-and-improve-efficacy-of-paclitaxel-in-bladder-cancer
#13
Amy Pan, Hongyong Zhang, Yuanpei Li, Tzu-Yin Lin, Fuli Wang, Joyce Lee, Mingshan Cheng, Marc Dall'Era, Tianhong Li, Ralph deVere White, Chong-Xian Pan, Kit S Lam
Chemotherapy commonly used in the treatment of advanced bladder cancer is only moderately effective and associated with significant toxicity. There has been no appreciable improvement in overall survival over the last three decades. The goal of this project is to develop and characterize bladder cancer-specific nanometer-scale micelles loaded with the chemotherapeutic drug paclitaxel (PTX) and determine the anti-tumor activity and toxicity. Micelle-building-material telodendrimers were synthesized through the stepwise conjugation of eight cholic acid units at one terminus of polyethylene glycol (PEG) and a bladder cancer-specific targeting peptide named PLZ4 at the other terminus...
October 21, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27593392/acute-photosensitisation-and-mortality-in-a-herd-of-dairy-cattle-in-tasmania
#14
H M Golder, N Moss, G Rogers, B Jackson, N Gannon, Ptw Wong, I J Lean
CASE HISTORY: A herd of Holstein, Jersey, or Holstein-Jersey cross lactating cattle of mixed ages presented with a sudden drop in milk yield in 94/678 cows on 3 October 2014 (Day 0). The herd was located in Gretna in the Derwent Valley (Tasmania, Australia) and had been grazing dryland pasture. CLINICAL FINDINGS: On Day 0 the cows variably showed recumbency, peracute photosensitisation, inflamed coronary bands, conjunctival erythema, periauricular oedema, distress indicated by kicking at the flank, bruxism, discomfort, weight shifting, vocalisation indicating pain and depression...
October 2, 2016: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/27584025/cancer-immunotherapy-new-applications-in-urologic-oncology
#15
Michael E Hurwitz, Joseph Sokhn, Daniel P Petrylak
PURPOSE OF REVIEW: Over the last 10 years, harnessing of the immune system to attack tumors has been one of the major breakthroughs in cancer, primarily through the use of immune checkpoint inhibitors (ICIs). This review will summarize current immune treatments in urologic malignancies and ongoing trials with novel combinations and in different disease settings. RECENT FINDINGS: Patients with urologic malignancies such as kidney and bladder cancer have benefited significantly from these advances with the approval of ICIs in both of these diseases...
November 2016: Current Opinion in Urology
https://www.readbyqxmd.com/read/27549224/correlation-of-bladder-wall-thickness-and-treatment-success-in-types-of-urinary-incontinence
#16
Burak Akselim, Melike Doğanay, Nilay Özcan, Sinem Akselim, Sabri Cavkaytar
INTRODUCTION AND HYPOTHESIS: The aim of the study was to investigate the correlation between mean bladder wall thickness (BWT) and treatment success in patients diagnosed with urinary incontinence, based on urodynamic test results. METHODS: In this prospective study, patient urinary incontinence type was identified using urodynamic tests. Patients (N = 125) were categorized into three groups: urodynamic stress incontinence (SUI), detrusor over-activity (DO) and mixed urinary incontinence...
August 22, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27536378/successful-treatment-of-urodynamic-detrusor-over-activity-in-a-young-patient-with-myasthenia-gravis-using-pretibial-nerve-stimulation-with-follow-up-to-two-years
#17
A Antoniou, J Mendez Rodrigues, N Comi
We report a rare case of Myasthenia gravis and overactive bladder successfully treated with pretibial nerve stimulation.
August 2016: JRSM Open
https://www.readbyqxmd.com/read/27519276/kr%C3%A3-ppel-like-factor-4-is-a-novel-prognostic-predictor-for-urothelial-carcinoma-of-bladder-and-it-regulates-twist1-mediated-epithelial-mesenchymal-transition
#18
Wei-Cheng Tseng, Cheng-Wei Chuang, Muh-Hwa Yang, Chin-Chen Pan, Der-Cherng Tarng
BACKGROUND: Krüppel-like factor 4 (KLF4) exerts tumor suppressive or oncogenic functions in a cell-type-dependent manner, but its prognostic role in urothelial carcinoma of bladder (UCB) remains unclear. We aimed to determine how KLF4 regulates epithelial-mesenchymal transition (EMT) and predicts patient survival in UCB. PATIENTS AND METHODS: The roles of KLF4 and other EMT regulators in cancer progression were studied in UCB specimens of 398 patients, UCB cell lines...
August 9, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27516652/a-review-of-possible-herbal-treatment-in-multiple-sclerosis-in-traditional-persian-medicine
#19
Rahil Ghanavati, Foroogh Namjoyan, Hosein Rezaee Zadeh
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS) and is the most common cause of neurologic disability in young adults (20-40 years old). About 2.5 million patients all over the world are suffering from MS. Common symptoms of the disease include sensory disorders, optic neuritis, and limb weakness. Following disease progression, other symptoms like fatigue, bladder disorders, and cognitive impairment also occur. Traditional Persian medicine (TPM) is an ancient medical system from 6000 years ago in Persia, where Iran was its most important state...
May 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27514530/over-expression-of-long-noncoding-rna-bancr-inhibits-malignant-phenotypes-of-human-bladder-cancer
#20
Anbang He, Yuchen Liu, Zhicong Chen, Jianfa Li, Mingwei Chen, Li Liu, Xinhui Liao, Zhaojie Lv, Yonghao Zhan, Chengle Zhuang, Junhao Lin, Weiren Huang, Hongbing Mei
BACKGROUND: Accumulating evidences indicated that lncRNAs play crucial regulatory roles in oncogenesis and progression of cancers. BRAF activated non-coding RNA (BANCR) has been identified to contribute to the progression of some human cancers. However, the relationship between BANCR and bladder cancer (BC) is largely unclear. METHODS: BANCR expression levels in BC, paired non-cancer tissues and BC cell lines were detected by real-time quantitative RT-PCR (qRT-PCR)...
2016: Journal of Experimental & Clinical Cancer Research: CR
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