Anouk van der Heide, Lisanne J Dommershuijsen, Lara M C Puhlmann, Raffael Kalisch, Bastiaan R Bloem, Anne E M Speckens, Rick C Helmich
People with Parkinson's disease (PD) are sensitive to effects of long-term stress, but might differ in stress resilience, i.e. the ability to maintain mental health despite adversity. It is unclear whether stress resilience in PD is predominantly determined by dopamine deficiency, psychosocial factors, or both. In PD animal models, chronic stressors accelerate disease progression, but evidence in humans is lacking. Our objectives were to (1) distinguish stressor-reactive from resilient PD patients, (2) identify resilience factors, and (3) compare symptom progression between stressor-reactive and resilient patients...
April 11, 2024: NPJ Parkinson's Disease