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Gastric mucosal protection

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https://www.readbyqxmd.com/read/29037897/overcoming-multiple-gastrointestinal-barriers-by-bilayer-modified-hollow-mesoporous-silica-nanocarriers
#1
Ying Wang, Yating Zhao, Yu Cui, Qinfu Zhao, Qiang Zhang, Sara Musetti, Karina A Kinghorn, Siling Wang
Oral administration of nanocarriers remains a significant challenge in the pharmaceutical sciences. The nanocarriers must efficiently overcome multiple gastrointestinal barriers including the harsh gastrointestinal environment, the mucosal layer, and the epithelium. Neutral hydrophilic surfaces are reportedly necessary for mucus permeation, but hydrophobic and cationic surfaces are important for efficient epithelial absorption. To accommodate these conflicting surface property requirements, we developed a strategy to modify nanocarrier surfaces with cationic cell-penetrating peptides (CPP) concealed by a hydrophilic succinylated casein (SCN) layer...
October 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28966253/identification-of-galectin-2-mucin-interaction-and-possible-formation-of-a-high-molecular-weight-lattice
#2
Mayumi Tamura, Dai Sato, Moeko Nakajima, Masanori Saito, Takaharu Sasaki, Toru Tanaka, Tomomi Hatanaka, Tomoharu Takeuchi, Yoichiro Arata
Galectins comprise a group of animal lectins characterized by their specificity for β-galactosides. Galectin-2 (Gal-2) is predominantly expressed in the gastrointestinal tract and has been identified as one of the main gastric mucosal proteins that are proposed to have a protective role in the stomach. As Gal-2 is known to form homodimers in solution, this may result in crosslinking of macromolecules with the sugar structures recognized by Gal-2. In this study, we report that Gal-2 could interact with mucin, an important component of gastric mucosa, in a β-galactoside-dependent manner...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28962187/the-therapeutic-effect-of-zerumbone-on-chronic-gastritis-via-antioxidant-mechanisms
#3
Liqing Li, Liang Kong, Hongquan Song
Effects of zerumbone on chronic gastritis remain unclear. The purpose of this study was to investigate the mechanism of the protective effect of zerumbone on the treatment of chronic gastritis in rats. The animal models of chronic gastritis in rats were established, and the surface damage of gastric mucosa was observed by gross anatomy; the changes of gastric mucosal tissue and surface morphology were observed by pathological sections of gastric mucosal tissues; the expressions of heme oxygenase-1 (HO-1) and nuclear factor E2-related factor 2 (Nrf-2) proteins of gastric mucosal tissues in each group were detected by western blot analysis; the activities of superoxide dismutase (SOD) and catalase (CAT) as well as the contents of reduced glutathione (GSH) and malondialdehyde (MDA) in gastric mucosal tissues were detected by kits...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28960628/treatment-of-gastric-eosinophilia-by-epicutaneous-immunotherapy-in-piglets-sensitized-to-peanuts
#4
L Mondoulet, N Kalach, V Dhelft, T Larcher, C Delayre-Orthez, P H Benhamou, J Spergel, H A Sampson, C Dupont
BACKGROUND: Eosinophilic Gastrointestinal Disorders (EGIDs) are hypersensitivity disorders frequently triggered by food allergy and manifested by mucosal eosinophilic infiltration at any level of the gastro-intestinal tract. This study established a model of gastric eosinophilia in peanut-sensitized piglets to evaluate the efficacy of epicutaneous immunotherapy (EPIT) for its treatment. METHODS: Experiments were carried out in piglets first sensitized by 3 intra-peritoneal injections of peanut protein extract (PPE) with adjuvant, and then given PPE orally for 10 days, a sequence leading to gastric eosinophilia assessed by endoscopy...
September 28, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28942222/the-effect-of-astragaloside-iv-on-ethanol-induced-gastric-mucosal-injury-in-rats-involvement-of-inflammation
#5
Shumin Qin, Keer Huang, Zhigang Fang, Jinjin Yin, Ruwei Dai
The present study aimed to investigate the potential protective effects of Astragaloside IV (AS-IV) against ethanol-induced gastric mucosal injury in rats. The animals were divided into 7 groups and pretreated with vehicle, various doses of AS-IV (1,2 and 4mg/kg, i.p.) or omeprazole (40mg/kg), 75min later, the gastric mucosal injury was induced by oral administration of ethanol. One hour after ethanol ingestion, the rats were euthanized and gastric tissues were collected to biochemical analyze. Myeloperoxidase (MPO), tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), interleukin 10 (IL-10), nuclear factor kappa B (NF-κB) p65 protein, TNF receptor-associated factor 2 (TRAF2) and nuclear NF-κB (nNF-κB) proteins were estimated by enzyme-linked immunosorbent assay or western blot analysis...
November 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28942137/protective-effect-of-oleane-12-en-3%C3%AE-ol-28-oic-acid-3%C3%AE-d-glucopyranoside-in-ethanol-induced-gastric-ulcer-by-enhancing-the-prostaglandin-e2-level
#6
Imran Kazmi, Shakir Saleem, Tanveer Ahmad, Muhammad Afzal, Fahad A Al-Abbasi, Vikas Kumar, Firoz Anwar
ETHNOPHARMACOLOGICAL RELEVANCE: Lantana camara is a popular invasive weed utilized in the management of ulcer in different part of world. Study of specific compound present in this plant responsible for their antulcer activity is main topic of concern. Current study designed for evaluation of the antiulcer activity of oleane-12-en-3β-ol-28-oic acid 3β-D-glucopyranoside (OAG) from Lantana camara L. MATERIALS AND METHODS: Antiulcer activity was carried out on NSAID's (Aspirin) and ethanol induced ulcer model...
September 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28928800/weikangning-therapy-in-functional-dyspepsia-and-the-protective-role-of-nrf2
#7
Yujuan Chang, Wei Wei, Li Tong, Yanjun Liu, Aimin Zhou, Jiande Chen, Ruhan Wei, Ping Zhang, Xiaolan Su
Functional dyspepsia (FD) is a non-organic gastrointestinal disorder that has a marked negative impact on quality of life. Compared with conventional pharmacological therapies, the traditional Chinese medicine weikangning (WKN) is a safe and effective treatment for FD. The present study aimed to determine the molecular mechanisms underlying the efficacy of WKN. The effect of different concentrations of WKN on the proliferation of the human gastric mucosal epithelial cell line GES-1 was assessed. The optimal WKN concentration to promote cell proliferation was determined, and this concentration was used to examine the effect of WKN compared with a domperidone-treated positive control group on the antioxidant capacity of GES-1 cells...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28927119/effect-of-glutamine-enriched-nutritional-support-on-intestinal-mucosal-barrier-function-mmp-2-mmp-9-and-immune-function-in-patients-with-advanced-gastric-cancer-during-perioperative-chemotherapy
#8
Juan Wang, Yanfen Li, Yuanling Qi
We studied the effects of glutamine-enriched nutritional support on intestinal mucosal barrier, matrix metalloproteinase (MMP)-2, MMP-9 and immune function during perioperative chemotherapy in patients with advanced gastric cancer. The study was conducted on 94 patients with advanced gastric cancer admitted from April 2015 to March 2016. They were randomly divided into observation and control groups, n=47. Control group was given basic nutritional support whereas glutamine-enriched nutritional support was given to patients in observation group...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926923/involvement-of-mapk-nf-%C3%AE%C2%BAb-signal-transduction-pathways-camellia-japonica-mitigates-inflammation-and-gastric-ulcer
#9
Md Rashedunnabi Akanda, Byung-Yong Park
Gastric ulcer is an important risk factor for human health globally. Camellia japonica (CJ) is a plant of which the fruits are used as traditional phytomedicine for inflammatory and immunomodulatory diseases; however, the underlying molecular mechanism has not been clarified. The present study aimed to investigate the immunopharmacological activities of Camellia japonica and validate its pharmacological targets. To evaluate the protective roles of Camellia japonica on LPS-induced inflammation in RAW 264.7 cells and HCl/EtOH-induced gastric ulcer in mice; we applied 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), nitric oxide (NO), reactive oxygen species (ROS), histopathology, malondialdehyde (MDA), quantitative real-time polymerase chain reaction (qPCR), immunohistochemistry (IHC), and western blot analyses...
September 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28919395/gastroprotective-effect-of-aucubin-against-ethanol-induced-gastric-mucosal-injury-in-mice
#10
Yang Yang, Bing Yin, Le Lv, Ziye Wang, Jiao He, Ziyang Chen, Xin Wen, Yongmin Zhang, Wenji Sun, Yang Li, Ye Zhao
AIMS: Aucubin, an iridoid glycoside, was isolated from seeds of Eucommia ulmoides Oliver. This study was aimed to evaluate the protective effect of aucubin against ethanol-induced gastric mucosal injury in mice. MATERIALS AND METHODS: Mice were orally administrated with aucubin (20, 40 and 80mg/kg) for 3 consecutive days. On the 3rd day, the mice of gastric mucosal injury were induced with 70% ethanol after the last administration of aucubin. Gastric tissue of mice were submitted for evaluating the severity of gastric mucosal injury...
September 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/28917082/protective-effect-of-salusin-%C3%AE-and-salusin-%C3%AE-against-ethanol-induced-gastric-ulcer-in-rats
#11
Ayhan Tanyeli, Ersen Eraslan, Elif Polat, Tuğba Bal
BACKGROUND: Alcohol consumption has been found to be associated with gastric ulcers, including gastric mucosal lesions. Salusin-α and salusin-β are bioactive peptides having 28 and 20 amino acids, respectively. Salusin-α and salusin-β immunoreactivity has been detected in the stomach and in the intestines. It has been reported that the salusins regulate the cytokine levels and decrease the infarct area in the heart tissue after ischemia. In this study, we investigated the effects of the salusins in the gastric injury formed with ethanol...
September 16, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28882824/a-physics-based-model-for-maintenance-of-the-ph-gradient-in-the-gastric-mucus-layer
#12
Owen L Lewis, James P Keener, Aaron L Fogelson
It is generally accepted that the gastric mucus layer provides a protective barrier between the lumen and the mucosa, shielding the mucosa from acid and digestive enzymes and preventing auto-digestion of the stomach epithelium. However, the precise mechanisms that contribute to this protective function are still up for debate. In particular, it is not clear what physical processes are responsible for transporting hydrogen protons, secreted within the gastric pits, across the mucus layer to the lumen without acidifying the environment adjacent to the epithelium...
September 7, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28874080/low-molecular-weight-gel-fraction-of-aloe-vera-exhibits-gastroprotection-by-inducing-matrix-metalloproteinase-9-inhibitory-activity-in-alcohol-induced-acute-gastric-lesion-tissues
#13
Chul-Hong Park, Hyeong-U Son, Chi-Yeol Yoo, Sang-Han Lee
CONTEXT: Aloe has been used for the prevention and cure of various diseases and symptoms including burns, injuries, oedema and pain. OBJECTIVE: This study determines the specific inhibitory activity of matrix metalloproteinase (MMP)-9 induced by the low molecular-weight gel fraction of Aloe vera (L.) Burm.f. (lgfAv) on alcohol-induced acute gastric lesions. MATERIALS AND METHODS: We examined the protective effects of oral (p.o.) administration of lgfAv (molecular weight cutoff <50...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28867726/short-chain-fatty-acid-acetate-protects-against-ethanol-induced-acute-gastric-mucosal-lesion-in-mice
#14
Jiaming Liu, Jindan Wang, Yilu Shi, Wei Su, Jie Chen, Zhengzheng Zhang, Guocan Wang, Fangyan Wang
Short chain fatty acids acetate and propionate have been demonstrated protective function in the intestinal mucosa. However, their impact on gastric mucosa has not yet been elucidated. The current study aimed to investigate the potential protective effects of acetate and propionate against ethanol-induced gastric mucosal lesion and the underlying mechanism in mice. ICR mice were orally treated with acetate and propionate, respectively, 30 min prior to the establishment of gastric mucosal injury model by challenge with absolute ethanol...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28856444/mechanisms-of-curcumin-induced-gastroprotection-against-ethanol-induced-gastric-mucosal-lesions
#15
Renata Czekaj, Jolanta Majka, Katarzyna Magierowska, Zbigniew Sliwowski, Marcin Magierowski, Robert Pajdo, Agata Ptak-Belowska, Marcin Surmiak, Slawomir Kwiecien, Tomasz Brzozowski
BACKGROUND: Curcumin, a pleiotropic substance used for centuries in traditional medicine, exhibits antioxidant, anti-inflammatory and antiproliferative efficacy against various tumours, but the role of curcumin in gastroprotection is little studied. We determined the effect of curcumin against gastric haemorrhagic lesions induced by 75% ethanol and alterations in gastric blood flow (GBF) in rats with cyclooxygenase-1 (COX-1) and COX-2 activity inhibited by indomethacin, SC-560 or rofecoxib, inhibited NO-synthase activity, capsaicin denervation and blockade of TRPV1 receptors by capsazepine...
August 30, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28849987/amelioration-of-ethanol-induced-apoptotic-dna-damage-and-ulcerative-injuries-in-the-mice-gastric-tissues-by-starch-oral-administration
#16
Sherin Ramadan Hamad, Hanan Ramadan Mohamed
Nowadays gastric ulcers become very common gastrointestinal disorders and numerous natural plant extracts exert promising anti-ulcerative effects. Therefore, this study was designed to evaluate the possible protective effect of dietary starch against ethanol induced gastric ulcers in mice. Post-administration of dietary starch for three consecutive days caused remarkable ameliorations in hemorrhagic lesions in gastric mucus and significant suppression in % incidence of ulceration, ulcer index and ulcer score induced by ethanol single administration...
August 29, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28844402/gastroprotective-and-mucosa-homeostatic-activities-of-coconut-milk-and-water-on-experimentally-induced-gastropathies-in-male-wistar-rats
#17
K O Ajeigbe, W M Owonikoko, V Egbe, I Iquere, G Adeleye
In this biphasic study, 45 male wistar rats were divided into 9 groups. In Phase 1, Group 1 was treated with normal saline and served as the overall control, group 2 was treated with 95% Ethanol and represents the ulcer control, groups 3 and 4 received coconut water (CW; 4ml/100g BWt) and milk (CM; 4ml/100g BWt) for 4weeks while group 5 received Omeprazole (Omep; 20mg/kg BWt) during terminal week. 95% Ethanol-induced ulceration followed the treatments in all except group 1. In the second phase, Group 1 was the overall control, group 2 served as ulcer control by receiving acetic acid only, group 3 received coconut milk, and group 4 received omep...
July 13, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28821162/oral-administration-of-thymoquinone-mitigates-the-effect-of-cisplatin-on-brush-border-membrane-enzymes-energy-metabolism-and-antioxidant-system-in-rat-intestine
#18
Faaiza Shahid, Zeba Farooqui, Subuhi Abidi, Iqbal Parwez, Farah Khan
Cisplatin (CP) is a widely used chemotherapeutic agent that elicits severe gastrointestinal toxicity. Nigella sativa, a member of family Ranunculaceae, is one of the most revered medicinal plant known for its numerous health benefits. Thymoquinone (TQ), a major bioactive component derived from the volatile oil of Nigella sativa seeds, has been shown to improve gastrointestinal functions in animal models of acute gastric/intestinal injury. In view of this, the aim of the present study was to investigate the protective effect of TQ on CP induced toxicity in rat intestine and to elucidate the mechanism underlying these effects...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28748627/genetic-ablation-of-carbonic-anhydrase-ix-disrupts-gastric-barrier-function-via-claudin-18-downregulation-and-acid-backflux
#19
T Li, X Liu, B Riederer, K Nikolovska, A K Singh, K A Mäkelä, A Seidler, Y Liu, G Gros, H Bartels, K H Herzig, U Seidler
AIM: This study aimed to explore the molecular mechanisms for the parietal cell loss and fundic hyperplasia observed in gastric mucosa of mice lacking the carbonic anhydrase 9 (CAIX). METHODS: We assessed the ability of CAIX-knockout and WT gastric surface epithelial cells to withstand a luminal acid load by measuring the pHi of exteriorized gastric mucosa in vivo using two-photon confocal laser scanning microscopy. Cytokines and claudin-18A2 expression was analysed by RT-PCR...
July 27, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28726772/mice-lacking-nf-%C3%AE%C2%BAb1-exhibit-marked-dna-damage-responses-and-more-severe-gastric-pathology-in-response-to-intraperitoneal-tamoxifen-administration
#20
Michael D Burkitt, Jonathan M Williams, Tristan Townsend, Rachael Hough, D Mark Pritchard
Tamoxifen (TAM) has recently been shown to cause acute gastric atrophy and metaplasia in mice. We have previously demonstrated that the outcome of Helicobacter felis infection, which induces similar gastric lesions in mice, is altered by deletion of specific NF-κB subunits. Nfkb1(-/-) mice developed more severe gastric atrophy than wild-type (WT) mice 6 weeks after H. felis infection. In contrast, Nfkb2(-/-) mice were protected from this pathology. We therefore hypothesized that gastric lesions induced by TAM may be similarly regulated by signaling via NF-κB subunits...
July 20, 2017: Cell Death & Disease
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