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Gastric mucosal protection

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https://www.readbyqxmd.com/read/29230642/a-case-of-a-protruded-lesion-formed-by-a-poorly-differentiated-intramucosal-adenocarcinoma-of-the-stomach-an-immunohistochemical-analysis
#1
Keiichiro Nakajo, Yasuhiro Oono, Takeshi Kuwata, Tomonori Yano
A 70-year-old woman underwent upper gastrointestinal endoscopy and was found to have a 25-mm protruded lesion in the gastric body. A biopsy revealed malignant cells. Endoscopic submucosal dissection was performed. Histopathologically, the tumor was mainly composed of poorly differentiated adenocarcinoma (PDA), while moderately differentiated adenocarcinoma was observed on its superficial layer. The tumor was located within the mucosal layer. PDAs rarely form a protruded lesion. Here, the presence of a moderately differentiated adenocarcinoma element in the superficial layer of the tumor might have protected the tumor cells from erosion, and solid proliferation of the PDA also contributed to its outward growth...
December 11, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29226586/protective-effect-of-gentiopicroside-from-gentiana-macrophylla-pall-in-ethanol-induced-gastric-mucosal-injury-in-mice
#2
Yang Yang, Ziye Wang, Li Zhang, Bing Yin, Le Lv, Jiao He, Ziyang Chen, Xin Wen, Boling Qiao, Wenji Sun, Minfeng Fang, Yongmin Zhang
Gentiopicroside isolated from gentiana macrophylla Pall. belongs to iridoid glycosides. This study aimed to evaluate the protective effect of gentiopicroside against ethanol-induced gastric mucosal injury in mice. Mice were proactively administrated with gentiopicroside by intragastric administration once a day for 3 consecutive days. On the 3rd day, gastric ulcer in mice was induced with 70% ethanol after the last intragastric administration. The stomach tissues were submitted for evaluation of the severity of gastric mucosal alterations...
December 11, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29223540/protective-effect-of-coptisine-free-base-on-indomethacin-induced-gastric-ulcers-in-rats-characterization-of-potential-molecular-mechanisms
#3
Chaodan Luo, Hanbin Chen, Yongfu Wang, Guosheng Lin, Cailan Li, Lihua Tan, Ziren Su, Xiaoping Lai, Jianhui Xie, Huifang Zeng
AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats. MATERIALS AND METHODS: CFB (10, 20 and 40mg/kg), berberine (20mg/kg) and lansoprazole (30mg/kg) were orally administrated to rats prior to indometacin ingestion, and gastric lesions were evaluated macroscopically and histologically, and further analyzed by ELISA, qRT-PCR and Western blot...
December 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/29222687/chrysophyllum-cainito-apple-star-a-fruit-with-gastroprotective-activity-in-experimental-ulcer-models
#4
Roseane Leandra da Rosa, Camila Leandra de Almeida, Lincon Bordigon Somensi, Thaise Boeing, Luisa Nathália Bolda Mariano, Clarissa de Medeiros Amorim Krueger, Priscila de Souza, Valdir Cechinel Filho, Luisa Mota da Silva, Sérgio Faloni de Andrade
The gastroprotective potential of the methanolic extracts from peels (MEPe), seeds (MESe) and pulp (MEPu) of Chrysophyllum cainito L. (Sapotaceae) fruits was evaluated in mice using ethanol/HCl- and indomethacin-induced ulcer, as well as the antiulcer effect of the juice and flour from this fruit. The lowest oral gastroprotective dose of MEPe, MESe and MEPu against ethanol/HCl was 3, 3 and 10 mg/kg, respectively. Moreover, all extracts increased mucin secretion at 176, 198 and 193%. Intraperitoneal administration of MEPe (0...
December 8, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29210057/a-functional-polymorphism-in-tff1-promoter-is-associated-with-the-risk-and-prognosis-of-gastric-cancer
#5
Weizhi Wang, Zheng Li, Jiwei Wang, Mulong Du, Bowen Li, Lei Zhang, Qing Li, Jianghao Xu, Linjun Wang, Fengyuan Li, Diancai Zhang, Hao Xu, Li Yang, Weida Gong, Fulin Qiang, Zhengdong Zhang, Zekuan Xu
Trefoil Factor 1 (TFF1, also named pS2), which serves as the gastrointestinal mucosal protector, is known as gastric-specific tumor suppressor gene. However, the genetic variants of TFF1 are still not well studied. In this study, we aim to explore the effects of tagging single nucleotide polymorphisms (tagSNPs) of TFF1 on risk and prognosis of gastric cancer. Seven tagSNPs of TFF1 gene were first analyzed in the test set, which was consisted of 753 cases and 950 cancer-free controls. Then, the validation set (940 cases and 1,042 controls) was used for further evaluation...
December 6, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29201579/overtube-assisted-foreign-body-removal-a-review-of-endoscopic-management-and-case-illustration
#6
Andrew Ofosu, Daryl Ramai, Madhavi Reddy
The ingestion of foreign bodies is a common medical emergency seen in both adults and children. In children, the most commonly ingested foreign bodies include coins, toys, magnets, and batteries. In adults, food bolus impaction represents the most common cause of foreign body ingestion. The majority of foreign bodies pass spontaneously. Sharp or pointed objects increase the risk of perforation. Emergent endoscopic intervention is indicated in cases of esophageal obstruction, ingestion of disk batteries, and sharp pointed objects in the esophagus...
September 29, 2017: Curēus
https://www.readbyqxmd.com/read/29192375/efficacy-of-rebamipide-in-organic-and-functional-dyspepsia-a-systematic-review-and-meta-analysis
#7
Mohamed Hasif Jaafar, Sher Zaman Safi, Maw-Pin Tan, Sanjay Rampal, Sanjiv Mahadeva
OBJECTIVE: The role of gastritis in dyspepsia remains controversial. We aimed to examine the efficacy of rebamipide, a gastric mucosal protective agent, in both organic and functional dyspepsia. DESIGN: A systematic review and meta-analysis was performed. The following databases were searched using the keywords ("rebamipide" OR "gastroprotective agent*" OR "mucosta") AND ("dyspepsia" OR "indigestion" OR "gastrointestinal symptoms"): PubMed, Wed of Science, Embase, CINAHL, Cochrane Clinical Trials Register...
December 1, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29188801/pharmacokinetic-and-pharmacodynamic-evidence-for-developing-an-oral-formulation-of-octreotide-against-gastric-mucosal-injury
#8
Xi-Nuo Li, Tai Rao, Yang-Fan Xu, Kang-Rui Hu, Zhang-Pei Zhu, Hao-Feng Li, Dian Kang, Yu-Hao Shao, Bo-Yu Shen, Xiao-Xi Yin, Lin Xie, Guang-Ji Wang, Yan Liang
Among the somatostatin analogues, octreotide (OCT) is the most commonly used in clinic via intravenous or subcutaneous injection to treat various diseases caused by increased secretion of growth hormone, gastrin or insulin. In order to assesse the feasibility of developing oral formulations of OCT, we conducted systematical pharmacokinetic and pharmacodynamic analyses of OCT in several animal models. The pharmacokinetic studies in rats showed that intragastric administration of OCT had extremely low bioavailability (<0...
November 30, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29166711/-effects-of-caspase-1-inhibitor-vx765-on-cold-restraint-stress-induced-acute-gastric-ulcer-in-mice
#9
S Q Zheng, X D Hong, T S Chen, P F Luo, S C Xiao
Objective: To investigate the protective effects of caspase-1 inhibitor VX765 on gastric mucosa of mice with cold-restraint stress-induced acute gastric ulcer. Methods: Twenty-four specific pathogen free male C57BL/6J mice were divided into normal control group (NC), cold restrain group (CR), VX765 pre-treatment+ cold restrain group (VCR), and rabeprazole pre-treatment+ cold restrain group (RCR) according to the random number table, with 6 mice in each group. Mice in group NC were injected intraperitoneally with solution of 10 mL/kg dimethylsulfoxide (DMSO) and phosphate buffer solution (PBS)...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29120271/apple-polyphenol-suppresses-indomethacin-induced-gastric-damage-in-experimental-animals-by-lowering-oxidative-stress-status-and-modulating-the-mapk-signaling-pathway
#10
Yi-Chen Lee, Chun-Wen Cheng, Huei-Jane Lee, Huei-Chuien Chu
Indomethacin is a nonsteroid anti-inflammatory drug (NSAID) that is used to alleviate pain and inflammation in clinical medicine. Previous studies indicated that NSAIDs can cause gastrointestinal mucosal complications, and it is associated with mucosal lipid peroxidation and oxidative damage. Based on the evidences, decreasing oxidative stress may be an ideal therapeutic strategy for preventing gastrointestinal ulcer. Apple (Rosaceae Malus sp.) is one of the most commonly consumed fruits worldwide. The abundant polyphenolic constituents have received increasing attention for decades...
November 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29076531/topical-protection-of-mice-laryngeal-mucosa-using-the-natural-product-cashew-gum
#11
Aline A Figueiredo, Ana P M Santana, Lucas A D Nicolau, Francisco J Batista-Lima, Deysi V T Wong, Larisse T Lucetti, Gabriela L P Batista, Natália A Caminha, Jand V R Medeiros, Durcilene A Silva, José R S A Leite, Armênio A Santos, Pedro M G Soares, Daniel Sifrim, Marcellus H L P Souza
OBJECTIVES/HYPOTHESIS: Evaluate the effect of in vitro exposure of mice laryngeal mucosa to solutions that simulated human gastric juice and to assess the topical protective effect of cashew gum on mice laryngeal mucosal integrity in vitro. STUDY DESIGN: Animal study. METHODS: Murine (Swiss) laryngeal samples were mounted in Ussing chambers. The luminal side of biopsies was exposed to solutions of different acidity with or without pepsin and/or taurodeoxycholic acid (TDC)...
October 27, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29067636/a-novel-finding-of-rapunzel-syndrome
#12
Itaru Iwama, Ryusuke Nambu, Tomoko Hara
Rapunzel syndrome is a rare form of gastric trichobezoar (hair ball) involving extension of a tail of the hair into the small bowel. A 13-year-old girl was admitted with a 4-day history of epigastric pain and nausea which worsened after meals. Abdominal ultrasound showed duodenal wall thickening and lymphadenopathy. Esophagogastroduodenoscopy identified a gastric trichobezoar with a tail extending into the duodenum. In addition, multiple longitudinal duodenal and jejunal ulcers were noted. The ulcers appeared to be a result of direct pressure by the tail itself against the intestinal mucosa...
October 24, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29037897/overcoming-multiple-gastrointestinal-barriers-by-bilayer-modified-hollow-mesoporous-silica-nanocarriers
#13
Ying Wang, Yating Zhao, Yu Cui, Qinfu Zhao, Qiang Zhang, Sara Musetti, Karina A Kinghorn, Siling Wang
Oral administration of nanocarriers remains a significant challenge in the pharmaceutical sciences. The nanocarriers must efficiently overcome multiple gastrointestinal barriers including the harsh gastrointestinal environment, the mucosal layer, and the epithelium. Neutral hydrophilic surfaces are reportedly necessary for mucus permeation, but hydrophobic and cationic surfaces are important for efficient epithelial absorption. To accommodate these conflicting surface property requirements, we developed a strategy to modify nanocarrier surfaces with cationic cell-penetrating peptides (CPP) concealed by a hydrophilic succinylated casein (SCN) layer...
October 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28966253/identification-of-galectin-2-mucin-interaction-and-possible-formation-of-a-high-molecular-weight-lattice
#14
Mayumi Tamura, Dai Sato, Moeko Nakajima, Masanori Saito, Takaharu Sasaki, Toru Tanaka, Tomomi Hatanaka, Tomoharu Takeuchi, Yoichiro Arata
Galectins comprise a group of animal lectins characterized by their specificity for β-galactosides. Galectin-2 (Gal-2) is predominantly expressed in the gastrointestinal tract and has been identified as one of the main gastric mucosal proteins that are proposed to have a protective role in the stomach. As Gal-2 is known to form homodimers in solution, this may result in crosslinking of macromolecules with the sugar structures recognized by Gal-2. In this study, we report that Gal-2 could interact with mucin, an important component of gastric mucosa, in a β-galactoside-dependent manner...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28962187/the-therapeutic-effect-of-zerumbone-on-chronic-gastritis-via-antioxidant-mechanisms
#15
Liqing Li, Liang Kong, Hongquan Song
Effects of zerumbone on chronic gastritis remain unclear. The purpose of this study was to investigate the mechanism of the protective effect of zerumbone on the treatment of chronic gastritis in rats. The animal models of chronic gastritis in rats were established, and the surface damage of gastric mucosa was observed by gross anatomy; the changes of gastric mucosal tissue and surface morphology were observed by pathological sections of gastric mucosal tissues; the expressions of heme oxygenase-1 (HO-1) and nuclear factor E2-related factor 2 (Nrf-2) proteins of gastric mucosal tissues in each group were detected by western blot analysis; the activities of superoxide dismutase (SOD) and catalase (CAT) as well as the contents of reduced glutathione (GSH) and malondialdehyde (MDA) in gastric mucosal tissues were detected by kits...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28960628/treatment-of-gastric-eosinophilia-by-epicutaneous-immunotherapy-in-piglets-sensitized-to-peanuts
#16
L Mondoulet, N Kalach, V Dhelft, T Larcher, C Delayre-Orthez, P H Benhamou, J Spergel, H A Sampson, C Dupont
BACKGROUND: Eosinophilic Gastrointestinal Disorders (EGIDs) are hypersensitivity disorders frequently triggered by food allergy and manifested by mucosal eosinophilic infiltration at any level of the gastro-intestinal tract. This study established a model of gastric eosinophilia in peanut-sensitized piglets to evaluate the efficacy of epicutaneous immunotherapy (EPIT) for its treatment. METHODS: Experiments were carried out in piglets first sensitized by 3 intra-peritoneal injections of peanut protein extract (PPE) with adjuvant, and then given PPE orally for 10 days, a sequence leading to gastric eosinophilia assessed by endoscopy...
September 28, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28942222/the-effect-of-astragaloside-iv-on-ethanol-induced-gastric-mucosal-injury-in-rats-involvement-of-inflammation
#17
Shumin Qin, Keer Huang, Zhigang Fang, Jinjin Yin, Ruwei Dai
The present study aimed to investigate the potential protective effects of Astragaloside IV (AS-IV) against ethanol-induced gastric mucosal injury in rats. The animals were divided into 7 groups and pretreated with vehicle, various doses of AS-IV (1,2 and 4mg/kg, i.p.) or omeprazole (40mg/kg), 75min later, the gastric mucosal injury was induced by oral administration of ethanol. One hour after ethanol ingestion, the rats were euthanized and gastric tissues were collected to biochemical analyze. Myeloperoxidase (MPO), tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), interleukin 10 (IL-10), nuclear factor kappa B (NF-κB) p65 protein, TNF receptor-associated factor 2 (TRAF2) and nuclear NF-κB (nNF-κB) proteins were estimated by enzyme-linked immunosorbent assay or western blot analysis...
November 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28942137/protective-effect-of-oleane-12-en-3%C3%AE-ol-28-oic-acid-3%C3%AE-d-glucopyranoside-in-ethanol-induced-gastric-ulcer-by-enhancing-the-prostaglandin-e2-level
#18
Imran Kazmi, Shakir Saleem, Tanveer Ahmad, Muhammad Afzal, Fahad A Al-Abbasi, Vikas Kumar, Firoz Anwar
ETHNOPHARMACOLOGICAL RELEVANCE: Lantana camara is a popular invasive weed utilized in the management of ulcer in different part of world. Study of specific compound present in this plant responsible for their antulcer activity is main topic of concern. Current study designed for evaluation of the antiulcer activity of oleane-12-en-3β-ol-28-oic acid 3β-D-glucopyranoside (OAG) from Lantana camara L. MATERIALS AND METHODS: Antiulcer activity was carried out on NSAID's (Aspirin) and ethanol induced ulcer model...
September 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28928800/weikangning-therapy-in-functional-dyspepsia-and-the-protective-role-of-nrf2
#19
Yujuan Chang, Wei Wei, Li Tong, Yanjun Liu, Aimin Zhou, Jiande Chen, Ruhan Wei, Ping Zhang, Xiaolan Su
Functional dyspepsia (FD) is a non-organic gastrointestinal disorder that has a marked negative impact on quality of life. Compared with conventional pharmacological therapies, the traditional Chinese medicine weikangning (WKN) is a safe and effective treatment for FD. The present study aimed to determine the molecular mechanisms underlying the efficacy of WKN. The effect of different concentrations of WKN on the proliferation of the human gastric mucosal epithelial cell line GES-1 was assessed. The optimal WKN concentration to promote cell proliferation was determined, and this concentration was used to examine the effect of WKN compared with a domperidone-treated positive control group on the antioxidant capacity of GES-1 cells...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28927119/effect-of-glutamine-enriched-nutritional-support-on-intestinal-mucosal-barrier-function-mmp-2-mmp-9-and-immune-function-in-patients-with-advanced-gastric-cancer-during-perioperative-chemotherapy
#20
Juan Wang, Yanfen Li, Yuanling Qi
We studied the effects of glutamine-enriched nutritional support on intestinal mucosal barrier, matrix metalloproteinase (MMP)-2, MMP-9 and immune function during perioperative chemotherapy in patients with advanced gastric cancer. The study was conducted on 94 patients with advanced gastric cancer admitted from April 2015 to March 2016. They were randomly divided into observation and control groups, n=47. Control group was given basic nutritional support whereas glutamine-enriched nutritional support was given to patients in observation group...
September 2017: Oncology Letters
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