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Gastric mucosal protection

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https://www.readbyqxmd.com/read/28056554/autophagy-protects-gastric-mucosal-epithelial-cells-from-ethanol-induced-oxidative-damage-via-mtor-signaling-pathway
#1
Weilong Chang, Jie Bai, Shaobo Tian, Muyuan Ma, Wei Li, Yuping Yin, Rui Deng, Jinyuan Cui, Jinjin Li, Guobin Wang, Peng Zhang, Kaixiong Tao
Alcohol abuse is an important cause of gastric mucosal epithelial cell injury and gastric ulcers. A number of studies have demonstrated that autophagy, an evolutionarily conserved cellular mechanism, has a protective effect on cell survival. However, it is not known whether autophagy can protect gastric mucosal epithelial cells against the toxic effects of ethanol. In the present study, gastric mucosal epithelial cells (GES-1 cells) and Wistar rats were treated with ethanol to detect the adaptive response of autophagy...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28056423/epiisopiloturine-hydrochloride-an-imidazole-alkaloid-isolated-from-pilocarpus-microphyllus-leaves-protects-against-naproxen-induced-gastrointestinal-damage-in-rats
#2
Lucas A D Nicolau, Nathalia S Carvalho, Dvison M Pacífico, Larisse T Lucetti, Karoline S Aragão, Leiz M C Véras, Marcellus H L P Souza, José R S A Leite, Jand Venes R Medeiros
OBJECTIVE: This study aimed to investigate the protective effect of epiisopiloturine hydrochloride (EPI), an imidazole alkaloid, on NAP-induced gastrointestinal damage in rats. METHODS: Initially, rats were pretreated with 0.5% carboxymethylcellulose (vehicle) or EPI (3, 10 and 30mg/kg, p.o. or i.p., groups 3-5, respectively) twice daily, for 2days. After 1h, NAP (80mg/kg, p.o.) was given. The control group received only vehicle (group 1) or vehicle+naproxen (group 2)...
January 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28056333/-recommendation-for-the-prevention-and-treatment-of-non-steroidal-anti-inflammatory-drug-induced-gastrointestinal-ulcers-and-its-complications
#3
(no author information available yet)
Non-steroidal anti-inflammatory drugs (NSAIDs) are a broad class of non glucocorticoid drugs which are extensively used in anti-inflammatory, analgesic, and antipyretic therapies. However, NSAIDs may cause many side effects, most commonly in gastrointestinal(GI) tract. Cardiovascular system, kidney, liver, central nervous system and hematopoietic system are also involved. NSAID-induced GI side effects not only endanger the patients' health, increase mortality, but also greatly increase the cost of medical care...
January 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28027824/protective-effect-of-chamomile-matricaria-recutita-l-decoction-extract-against-alcohol-induced-injury-in-rat-gastric-mucosa
#4
Mohamed-Amine Jabri, Nadhem Aissani, Haifa Tounsi, Mohsen Sakly, Lamjed Marzouki, Hichem Sebai
BACKGROUND: Matricaria recutita L. (Asteraceae), German chamomile, has been widely used in the traditional Tunisian medicine because of having the powerful health benefits. the current study was conducted to determine the protective effect of chamomile (Matricaria recutita L.) decoction extract (CDE) in ethanol-induced ulcer and oxidative stress on gastric mucosa in rat. METHODS: Adult male wistar rats were used and divided into seven groups: Control, EtOH, EtOH+various doses of CDE (25, 50 and 100mg/kg, b...
December 21, 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28013186/ponciretin-attenuates-ethanol-induced-gastric-damage-in-mice-by-inhibiting-inflammatory-responses
#5
Geum-Dan Kang, Dong-Hyun Kim
BACKGROUND: Poncirin (PO) and isosakuranetin (or ponciretin [PT]) are compounds found in fruits of the genus Citrus. They are frequently used in traditional Chinese medicine for the treatment of inflammation and asthma. Therefore, we examined their anti-gastritis effects in vitro and in vivo. METHODS: The anti-inflammatory effects of PO and PT were examined using ethanol- or LPS-stimulated KATO III cells. Gastritis was induced in ICR mice via intragastric injection of absolute ethanol...
December 22, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/28011952/role-of-sensory-afferent-nerves-lipid-peroxidation-and-antioxidative-enzymes-in-the-carbon-monoxide-induced-gastroprotection-against-stress-ulcerogenesis
#6
S Kwiecien, K Magierowska, M Magierowski, M Surmiak, M Hubalewska-Mazgaj, R Pajdo, Z Sliwowski, A Chmura, D Wojcik, T Brzozowski
Carbon monoxide (CO) is a physiological gaseous mediator recently implicated in the mechanism of gastric mucosal defense due to its vasodilatory and antioxidative properties. Small quantities of endogenous CO are produced during heme degradation by heme oxygenase (HO-1), however, the involvement of the capsaicin-sensitive afferent neurons releasing calcitonin gene related peptide (CGRP) and anti-oxidative factors and mechanisms in the CO-induced gastroprotection against stress ulcerogenesis has been little studied...
October 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28011266/rebamipide-induces-the-gastric-mucosal-protective-factor-cyclooxygenase-2-via-activation-of-5-amp-activated-protein-kinase
#7
Sunyoung Lee, Seongkeun Jeong, Wooseong Kim, Dohoon Kim, Yejin Yang, Jeong-Hyun Yoon, Byung Joo Kim, Do Sik Min, Yunjin Jung
Rebamipide, an amino acid derivative of 2(1H)-quinolinone, has been used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. Induction of cyclooxygenase (COX)-2, a gastric mucosal protective factor, by rebamipide has been suggested as the major mechanism of the drug action. However, how rebamipide induces COX-2 at the molecular level needs further investigation. In this study, the molecular mechanism underlying the induction of COX-2 by rebamipide was investigated. In gastric carcinoma cells and macrophage cells, rebamipide induced phosphorylation of AMP-activated protein kinase (AMPK), leading to phosphorylation of acetyl-CoA carboxylase (ACC), a substrate of AMPK...
December 21, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27995192/a-basic-study-of-the-effect-of-the-shielding-method-with-polyglycolic-acid-fabric-and-fibrin-glue-after-endoscopic-submucosal-dissection
#8
Tsujimoto Hiroyuki, Yamanaka Kohki, Miyamoto Hiroe, Horii Tsunehito, Abe Rie, Tanaka Shota, Torii Hiroko, Ozamoto Yuki, Toshitaka Takagi, Takimoto Kengo, Torii Takashi, Konishi Hideyuki, Takamori Hideki, Hagiwara Akeo
Background and study aims: Recently, the shielding method with polyglycolic acid (PGA) fabric and fibrin glue (P-F method) has been reported to prevent serious complications after endoscopic submucosal dissection (ESD). However, the effectiveness and mechanism to prevent complications by this method remain unclear and the corresponding basic research has not been fully conducted. Methods and results: We examined the effectiveness and mechanism of the P-F method, using a surgical ESD model of canine stomach and in vitro experiments...
December 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27930268/recombinant-bacillus-subtilis-spores-expressing-cholera-toxin-b-subunit-and-helicobacter-pylori-urease-b-confers-protection-against-h-pylori-in-mice
#9
Zhenwen Zhou, Hui Dong, Shuwen Yao, Yanmei Huang, Bingshao Liang, Yongqiang Xie, Yan Long, Jialiang Mai, Sitang Gong
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma. The limitations of current therapies for Helicobacter pylori infection include poor compliance and antibiotic resistance. Therefore, an effective anti-H. pylori vaccine would be an alternative or complement to antibiotic treatment. Urease B (UreB) is considered an ideal vaccine antigen against H. pylori infection. In this study, cholera toxin B subunit (CTB), a mucosal adjuvant, was used to enhance the immunogenicity of novel Bacillus subtilis spores vaccine that express CTB-UreB along with the B...
December 8, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27895392/determination-of-the-adequate-dosage-of-rebamipide-a-gastric-mucoprotective-drug-to-prevent-low-dose-aspirin-induced-gastrointestinal-mucosal-injury
#10
Kazuhiro Ota, Toshihisa Takeuchi, Sadaharu Nouda, Haruhiko Ozaki, Shinpei Kawaguchi, Yoshiaki Takahashi, Satoshi Harada, Shoko Edogawa, Yuichi Kojima, Takanori Kuramoto, Kazuhide Higuchi
Small intestinal mucosal injury caused by low-dose aspirin is a common cause of obscure gastrointestinal bleeding. We aimed to investigate the protective effects and optimal dose of rebamipide for low-dose aspirin-induced gastrointestinal mucosal injury. In this prospective randomized trial, 45 healthy volunteers (aged 20-65 years) were included and divided into three groups. The groups received enteric-coated aspirin 100 mg (low-dose aspirin) plus omeprazole 10 mg (Group A: proton pump inhibitor group), low-dose aspirin plus rebamipide 300 mg (Group B: standard-dose group), or low-dose aspirin plus rebamipide 900 mg (Group C: high-dose group)...
November 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27873354/gastroprotective-effect-of-esculin-on-ethanol-induced-gastric-lesion-in-mice
#11
Weifeng Li, Yu Wang, Xiumei Wang, Hailin Zhang, Zehong He, Wenbing Zhi, Fang Liu, Xiaofeng Niu
The gastroprotective effect of esculin was investigated in a mouse model of ethanol-induced gastric lesion. Administration of esculin at doses of 5, 10, and 20 mg/kg body weight prior to ethanol ingestion led to significant gastroprotection compared to untreated mice. Gastric mucosal lesions were evaluated by macroscopic and histopathological alterations, lesion index, and myeloperoxidase (MPO) activity. Pretreatment with esculin significantly reduced macroscopic and histopathological damage, gastric lesion index, and MPO activity in a dose-dependent manner...
November 22, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27864656/nitric-oxide-and-hydrogen-sulfide-interact-when-modulating-gastric-physiological-functions-in-rodents
#12
Larisse Tavares Lucetti, Renan Oliveira Silva, Ana Paula Macedo Santana, Bruno de Melo Tavares, Mariana Lima Vale, Pedro Marcos Gomes Soares, Francisco José Batista de Lima Júnior, Pedro Jorge Caldas Magalhães, Fernando de Queiroz Cunha, Ronaldo de Albuquerque Ribeiro, Jand-Venes Rolim Medeiros, Marcellus Henrique Loiola Ponte Souza
AIM: The objective was to evaluate the effects of nitric oxide (NO) and hydrogen sulfide (H2S) donors and possible interactions between these two systems in modulating gastric function. METHODS: Mice received saline, sodium nitroprusside (SNP), or sodium hydrosulfite (NaHS), and after 1 h, the animals were killed for immunofluorescence analysis of CSE or eNOS expressions, respectively. Other groups received saline, SNP, NaHS, Lawesson's reagent (H2S donor), PAG + SNP, L-NAME, L-NAME + NaHS, or L-NAME + Lawesson's reagent...
November 18, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27859804/gastric-mucosal-cracked-and-cobblestone-like-changes-by-the-use-of-proton-pump-inhibitors
#13
Shuichi Miyamoto, Mototsugu Kato, Momoko Tsuda, Kana Matsuda, Tetsuhito Muranaka, Satoshi Abiko, Masayoshi Ono, Takeshi Mizushima, Saori Omori, Keiko Yamamoto, Katsuhiro Mabe, Shoko Ono, Takahiko Kudo, Yuichi Shimizu, Naoya Sakamoto
OBJECTIVES: Use of proton pump inhibitors (PPIs) is histologically associated with oxyntic gland dilatations. Two interesting mucosal changes are often detected endoscopically in patients who use PPIs: gastric cracked mucosa (GCM) and gastric cobblestone-like mucosa (GCSM). The aim of this study was to clarify the relationship between PPI use and these mucosal changes. METHODS: This was a single-center observational study. All successive subjects who underwent a routine esophagogastroduodenoscopy (EGD) between August and November 2014 in Hokkaido University Hospital were enrolled...
November 17, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/27825819/interaction-between-endogenous-carbon-monoxide-and-hydrogen-sulfide-in-the-mechanism-of-gastroprotection-against-acute-aspirin-induced-gastric-damage
#14
Marcin Magierowski, Katarzyna Magierowska, Magdalena Hubalewska-Mazgaj, Juliusz Adamski, Dominik Bakalarz, Zbigniew Sliwowski, Robert Pajdo, Slawomir Kwiecien, Tomasz Brzozowski
Acetylsalicylic acid (ASA) is mainly recognized as painkiller or anti-inflammatory drug. However, ASA causes serious side effects towards gastrointestinal (GI) tract which limits its usefulness. Carbon monoxide (CO) and hydrogen sulfide (H2S) have been described to act as important endogenous messengers and mediators of gastroprotection but whether they can interact in gastroprotection against acute ASA-induced gastric damage remains unknown. In this study male Wistar rats were pretreated with 1) vehicle (saline, i...
December 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27825384/inhibiting-the-proton-pump-mechanisms-benefits-harms-and-questions
#15
Jeffrey K Aronson
Inhibition of the H(+)/K(+)-adenosine triphosphatase (the proton pump) is the final common mechanistic pathway in reducing gastric acid secretion pharmacologically. Proton pump inhibitors are widely used in upper gastrointestinal diseases, including gastric and duodenal ulcers, eradication of Helicobacter pylori in combination with antibiotics, gastroesophageal reflux disease, Zollinger-Ellison syndrome, eosinophilic esophagitis, and prevention of non-steroidal anti-inflammatory drug-induced peptic ulceration...
November 9, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27816726/astragaloside-iv-protects-rat-gastric-mucosa-against-aspirin-induced-damage
#16
Dan-Dan Fan, Shan Lin, Yan-Ping Song, Ze-Yu Wang, Bo Liu, Sai-Nan Gao, Yu-Hua Fan, Shan Zhu, Sen Li, Lei Jiang
Aspirin (Asp) is commonly used as an anti-inflammatory drug, but the long-term usage of Asp can lead to severe gastrointestinal damage. Thus the co-administering of Asp with another drug that can suppress its side effect while having no impact on its anti-inflammatory activity would be ideal. Astragaloside IV (AST-IV) is a natural anti-inflammatory compound that has been shown to protect rat gastric mucosa from anhydrous ethanol-inflicted damage. In this study, we investigated whether AST-IV could protect rat gastric mucosa against Asp-induced gastric mucosal damage...
December 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27814791/lipoic-acid-protects-gastric-mucosa-from-ethanol-induced-injury-in-rat-through-a-mechanism-involving-aldehyde-dehydrogenase-2-activation
#17
Jia-Hui Li, Gui-Xia Ju, Jun-Lin Jiang, Nian-Sheng Li, Jun Peng, Xiu-Ju Luo
Numerous studies demonstrate that reactive aldehydes are highly toxic and aldehyde dehydrogenase 2 (ALDH2)-mediated detoxification of reactive aldehydes is thought as an endogenous protective mechanism against reactive aldehydes-induced cell injury. This study aims to explore whether lipoic acid, a potential ALDH2 activator, is able to protect gastric mucosa from ethanol-induced injury through a mechanism involving clearance of reactive aldehydes. The rats received 60% of acidified ethanol through intragastric administration and held for 1 h to establish a mucosal injury model...
November 2016: Alcohol
https://www.readbyqxmd.com/read/27814789/novokinin-inhibits-gastric-acid-secretion-and-protects-against-alcohol-induced-gastric-injury-in-rats
#18
Yang Zhang, Minghui Xiu, Jinhong Jiang, Jianzheng He, Dongqin Li, Shiwei Liang, Qiang Chen
Novokinin (Arg-Pro-Leu-Lys-Pro-Trp), a potent vasorelaxing and hypotensive peptide modified from ovokinin, exhibits highly selective affinity for the AT2 receptor. However, its role in gastrointestinal functions is still not fully understood. In this study, we found that novokinin inhibited basal gastric acid secretion and protected gastric mucosa from alcohol-induced injury in a dose-related manner in rats after intracerebroventricular (i.c.v.) administration. Novokinin significantly decreased basal gastric acid output at the dose of 50 and 100 nmol/rat...
November 2016: Alcohol
https://www.readbyqxmd.com/read/27813628/quercetin-attenuates-indomethacin-induced-acute-gastric-ulcer-in-rats
#19
Abdullah Glil Rada Alkushi, Naser Ahmed Mahmoud Elsawy
BACKGROUND: Peptic ulcer diseases are common and are induced by many factors, including stress, smoking, and ingestion of non-steroidal anti-inflammatory drugs. Quercetin is considered to be an anti-oxidant with healing effects on many experimental toxic injuries. MATERIALS AND METHODS: The present study aimed to explore the possible effect of quercetin on acute gastric ulcer induced by indomethacin in rats. Three groups received indomethacin (30mg/kg body weight) orally by orogastric gavage on two consecutive days...
November 4, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27780710/the-effects-of-baicalein-on-gastric-mucosal-ulcerations-in-mice-protective-pathways-and-anti-secretory-mechanisms
#20
Ana Roseli S Ribeiro, José Diego do Nascimento Valença, Jeferson da Silva Santos, Thaise Boeing, Luisa Mota da Silva, Sérgio Faloni de Andrade, Ricardo L C Albuquerque-Júnior, Sara Maria Thomazzi
Many flavonoids have been shown to present good results for the treatment of gastric ulcers. Baicalein, a bioactive flavonoid derived from the Scutellaria baicalensis Georgi root, possesses several biological effects, such as anti-inflammatory and antioxidant. This study was conducted to assess the gastroprotective properties of baicalein. Anti-ulcerogenic assay was performed using the protocol of ulcer induced by ethanol/HCl in mice; then, the role of presynaptic α2-receptors, sulfhydryl (SH) compounds, nitric oxide (NO), prostaglandin (PG) and ATP-sensitive K(+) (KATP) channels in gastroprotection of baicalein was investigated...
December 25, 2016: Chemico-biological Interactions
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