keyword
MENU ▼
Read by QxMD icon Read
search

O-glcnac aging

keyword
https://www.readbyqxmd.com/read/28502704/ketogenic-diet-leads-to-o-glcnac-modification-in-the-btbr-t-tf-j-mouse-model-of-autism
#1
Christopher Newell, Virginia L Johnsen, Nellie C Yee, Warren J Xu, Matthias S Klein, Aneal Khan, Jong M Rho, Jane Shearer
BACKGROUND: Protein O-linked-β-N-acetyl glucosamine (O-GlcNAc) is a post-translational modification to Ser/Thr residues that integrates energy supply with demand. Abnormal O-GlcNAc patterning is evident in several neurological disease states including epilepsy, Alzheimer's disease and autism spectrum disorder (ASD). A potential treatment option for these disorders includes the high-fat, low-carbohydrate, ketogenic diet (KD). The goal of this study was to determine whether the KD induces changes in O-GlcNAc in the BTBR(T+tf/j) (BTBR) mouse model of ASD...
May 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28487326/xbp1-x-box-binding-protein-1-dependent-o-glcnacylation-is-neuroprotective-in-ischemic-stroke-in-young-mice-and-its-impairment-in-aged-mice-is-rescued-by-thiamet-g
#2
Meng Jiang, Shu Yu, Zhui Yu, Huaxin Sheng, Ying Li, Shuai Liu, David S Warner, Wulf Paschen, Wei Yang
BACKGROUND AND PURPOSE: Impaired protein homeostasis induced by endoplasmic reticulum dysfunction is a key feature of a variety of age-related brain diseases including stroke. To restore endoplasmic reticulum function impaired by stress, the unfolded protein response is activated. A key unfolded protein response prosurvival pathway is controlled by the endoplasmic reticulum stress sensor (inositol-requiring enzyme-1), XBP1 (downstream X-box-binding protein-1), and O-GlcNAc (O-linked β-N-acetylglucosamine) modification of proteins (O-GlcNAcylation)...
May 9, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28339907/o-linked-%C3%AE-n-acetylglucosamine-modification-of-proteins-is-essential-for-foot-process-maturation-and-survival-in-podocytes
#3
Shinya Ono, Shinji Kume, Mako Yasuda-Yamahara, Kosuke Yamahara, Naoko Takeda, Masami Chin-Kanasaki, Hisazumi Araki, Osamu Sekine, Hideki Yokoi, Masashi Mukoyama, Takashi Uzu, Shin-Ichi Araki, Hiroshi Maegawa
Background.: O-linked β- N -acetylglucosamine modification O-GlcNAcylation) is a post-translational modification of intracellular proteins, serving as a nutrient sensor. Growing evidence has demonstrated its physiological and pathological importance in various mammalian tissues. This study examined the physiological role of O-GlcNAcylation in podocyte function and development. Methods.: O-GlcNAc transferase (Ogt) is a critical enzyme for O-GlcNAcylation and resides on the X chromosome...
February 27, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28272406/o-glcnacylation-of-skn-1-modulates-the-lifespan-and-oxidative-stress-resistance-in-caenorhabditis-elegans
#4
Hongyuan Li, Xin Liu, Dan Wang, Liangping Su, Tingting Zhao, Zhongwei Li, Cong Lin, Yu Zhang, Baiqu Huang, Jun Lu, Xiaoxue Li
In C. elegans, the transcription factor skinhead-1 (SKN-1), the ortholog of human NF-E2-related factor 2 (Nrf-2), plays important roles in oxidative stress defense and aging processes. It has been documented that the activity of SKN-1 is regulated by its phosphorylation modification. However, whether other posttranslational modifications of SKN-1 affect its function remains unclear to date. Here we report, for the first time, that SKN-1 is O-GlcNAcylated at Ser470 and Thr493 by O-GlcNActransferase OGT-1. By generating the double mutations of Ser470/Thr493 in the wild type and skn-1(zu67) worms, respectively, we found that disruption of O-GlcNAc modification on SKN-1 repressed the accumulation of SKN-1 in the intestinal nuclei, and decreased the activities of SKN-1 in modulating lifespan and oxidative stress resistance...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28115479/o-glcnac-transferase-is-essential-for-sensory-neuron-survival-and-maintenance
#5
Cathy Su, Thomas L Schwarz
O-GlcNAc transferase (OGT) regulates a wide range of cellular processes through the addition of the O-GlcNAc sugar moiety to thousands of protein substrates. Because nutrient availability affects the activity of OGT, its role has been broadly studied in metabolic tissues. OGT is enriched in the nervous system, but little is known about its importance in basic neuronal processes in vivo Here, we show that OGT is essential for sensory neuron survival and maintenance in mice. Sensory neuron-specific knock-out of OGT results in behavioral hyposensitivity to thermal and mechanical stimuli accompanied by decreased epidermal innervation and cell-body loss in the dorsal root ganglia...
February 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27497832/o-glcnacylation-and-neurodegeneration
#6
REVIEW
Willayat Y Wani, John C Chatham, Victor Darley-Usmar, Lori L McMahon, Jianhua Zhang
O-GlcNAcylation is a dynamic form of protein glycosylation which involves the addition of β-d-N-acetylglucosamine (GlcNAc) via an O-linkage to serine or threonine residues of nuclear, cytoplasmic, mitochondrial and transmembrane proteins. The two enzymes responsible for O-GlcNAc cycling are O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA); their expression and activities in brain are age dependent. More than 1000 O-GlcNAc protein targets have been identified which play critical roles in many cellular processes...
August 4, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27341820/monosaccharide-profiling-of-silkworm-bombyx-mori-l-nervous-system-during-development-and-aging
#7
Seçkin Soya, Umut Şahar, Sabire Karaçalı
Glycoconjugates have various functions in differentiation, development, aging and in all aspects of normal functioning of organisms. The reason for increased research on this topic is that glycoconjugates locate mostly on the cell surface and play crucial biological roles in the nervous system including brain development, synaptic plasticity, learning, and memory. Considering their roles in the nervous system, information about their existence in the insect nervous system is rather sparse. Therefore, in order to detect monosaccharide content of N- and O-glycans, we carried out capLC-ESI-MS/MS analysis to determine the concentration changes of glucose, mannose, galactose, N-acetylglucosamine (GlcNAc), N-acetylgalactosamine (GalNAc), fucose, xylose, arabinose, and ribose monosaccharides in the nervous system of Bombyx mori during development and aging processes...
September 2016: Invertebrate Neuroscience: IN
https://www.readbyqxmd.com/read/27259471/roles-of-o-glcnac-in-chronic-diseases-of-aging
#8
REVIEW
Partha S Banerjee, Olof Lagerlöf, Gerald W Hart
O-GlcNAcylation, a dynamic nutrient and stress sensitive post-translational modification, occurs on myriad proteins in the cell nucleus, cytoplasm and mitochondria. O-GlcNAcylation serves as a nutrient sensor to regulate signaling, transcription, translation, cell division, metabolism, and stress sensitivity in all cells. Aberrant protein O-GlcNAcylation plays a critical role both in the development, as well as in the progression of a variety of age related diseases. O-GlcNAcylation underlies the etiology of diabetes, and changes in specific protein O-GlcNAc levels and sites are responsible for insulin expression and sensitivity and glucose toxicity...
October 2016: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/27037841/aberrant-o-glcnacylation-disrupts-gne-enzyme-activity-in-gne-myopathy
#9
Dorit Bennmann, Wenke Weidemann, Annett Thate, Denise Kreuzmann, Rüdiger Horstkorte
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme for the biosynthesis of sialic acids. Sialic acids are terminal monosaccharides of glycoconjugates and gangliosides, which have an essential influence on various cell interactions. The sialylation of proteins varies during development, aging, and pathogenesis of degenerative diseases such as Morbus Alzheimer, diabetes mellitus type II, or myopathies. Mutation of methionine 743 in the GNE leads to a 30% reduction of the enzyme activity and is responsible for an aggressive form of GNE myopathy...
June 2016: FEBS Journal
https://www.readbyqxmd.com/read/26816085/evidence-for-an-imbalance-between-tau-o-glcnacylation-and-phosphorylation-in-the-hippocampus-of-a-mouse-model-of-alzheimer-s-disease
#10
Eleonora Gatta, Tony Lefebvre, Silvana Gaetani, Marc dos Santos, Jordan Marrocco, Anne-Marie Mir, Tommaso Cassano, Stefania Maccari, Ferdinando Nicoletti, Jérôme Mairesse
Intracellular accumulation of hyperphosphorylated tau protein is linked to neuronal degeneration in Alzheimer's disease (AD). Mounting evidence suggests that tau phosphorylation and O-N-acetylglucosamine glycosylation (O-GlcNAcylation) are mutually exclusive post-translational modifications. O-GlcNAcylation depends on 3-5% of intracellular glucose that enters the hexosamine biosynthetic pathway. To our knowledge, the existence of an imbalance between tau phosphorylation and O-GlcNAcylation has not been reported in animal models of AD, as yet...
March 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/26311324/the-augmentation-of-o-glcnacylation-reduces-glyoxal-induced-cell-injury-by-attenuating-oxidative-stress-in-human-retinal-microvascular-endothelial-cells
#11
Guo Dong Liu, Chong Xu, Le Feng, Fang Wang
It has recently been reported that O-linked β-N-acetyl glucosamine (O-GlcNAc) modification (a simple intracellular serine (Ser)/threonine (Thr)-linked monosaccharide) in human retinal microvascular endothelial cells (HRECs) is related to diabetic retinopathy (DR). During O-GlcNAcylation, O-GlcNAc is added to Ser and Thr residues. As the generation of reactive oxygen species (ROS) is one of the characteristics of advanced glycation end product (AGE) injury, and the most important key pathogenic factor of DR, in the present study, we aimed to investigate the association between O-GlcNAcylation and ROS generation in order to ascertain whether O-GlcNAcylation mitigates cellular injury through the generation of ROS...
October 2015: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/25709599/30-years-old-o-glcnac-reaches-the-age-of-reason-regulation-of-cell-signaling-and-metabolism-by-o-glcnacylation
#12
Tony Lefebvre, Tarik Issad
No abstract text is available yet for this article.
2015: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/25538681/proteomic-analysis-of-pig-sus-scrofa-olfactory-soluble-proteome-reveals-o-linked-n-acetylglucosaminylation-of-secreted-odorant-binding-proteins
#13
Patricia Nagnan-Le Meillour, Anne-Sophie Vercoutter-Edouart, Frédérique Hilliou, Chrystelle Le Danvic, Frédéric Lévy
The diversity of olfactory binding proteins (OBPs) is a key point to understand their role in molecular olfaction. Since only few different sequences were characterized in each mammalian species, they have been considered as passive carriers of odors and pheromones. We have explored the soluble proteome of pig nasal mucus, taking benefit of the powerful tools of proteomics. Combining two-dimensional electrophoresis, mass spectrometry, and western-blot with specific antibodies, our analyses revealed for the first time that the pig nasal mucus is mainly composed of secreted OBP isoforms, some of them being potentially modified by O-GlcNAcylation...
2014: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/25386167/three-decades-of-research-on-o-glcnacylation-a-major-nutrient-sensor-that-regulates-signaling-transcription-and-cellular-metabolism
#14
REVIEW
Gerald W Hart
Even though the dynamic modification of polypeptides by the monosaccharide, O-linked N-acetylglucosamine (O-GlcNAcylation) was discovered over 30 years ago, its physiological significance as a major nutrient sensor that regulates myriad cellular processes has only recently been more widely appreciated. O-GlcNAcylation, either on its own or by its interplay with other post-translational modifications, such as phosphorylation, ubiquitination, and others, modulates the activities of signaling proteins, regulates most components of the transcription machinery, affects cell cycle progression and regulates the targeting/turnover or functions of myriad other regulatory proteins, in response to nutrients...
2014: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/25173736/o-glcnac-transferase-and-o-glcnacase-achieving-target-substrate-specificity
#15
REVIEW
Alexis K Nagel, Lauren E Ball
O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) catalyze the dynamic cycling of intracellular, post-translational O-GlcNAc modification on thousands of Ser/Thr residues of cytosolic, nuclear, and mitochondrial signaling proteins. The identification of O-GlcNAc modified substrates has revealed a functionally diverse set of proteins, and the extent of O-GlcNAcylation fluctuates in response to nutrients and cellular stress. As a result, OGT and OGA are implicated in widespread, nutrient-responsive regulation of numerous signaling pathways and transcriptional programs...
October 2014: Amino Acids
https://www.readbyqxmd.com/read/24987494/aging-leads-to-elevation-of-o-glcnacylation-and-disruption-of-mitochondrial-homeostasis-in-retina
#16
Lin Zhao, Zhihui Feng, Xuan Zou, Ke Cao, Jie Xu, Jiankang Liu
Retina is particularly susceptible to aging as oxidative damage accumulates within retina, leading to age-related retinal dysfunction or even visual loss. However, the underlying mechanisms still remain obscure and effective therapeutic strategy is urgently in need. Here, we quested for the answer particularly focusing on mitochondrial homeostasis and O-GlcNAcylation in rat retina. By comparing expression of electron transfer chain complexes and key factors in mitochondrial biogenesis and dynamics in retinas of aged and young Sprague-Dawley rats, we found that mitochondrial Complex I, II, IV and V were increased in aged retina with decreased mtTFA and Mfn2...
2014: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/24859566/increased-o-glcnac-levels-correlate-with-decreased-o-glcnacase-levels-in-alzheimer-disease-brain
#17
COMPARATIVE STUDY
Sarah Förster, Andrew S Welleford, Judy C Triplett, Rukhsana Sultana, Brigitte Schmitz, D Allan Butterfield
The potential role of the posttranslational modification of proteins with O-linked N-acetyl-β-d-glucosamine (O-GlcNAc) in the pathogenesis of Alzheimer disease (AD) has been studied extensively, yet the exact function of O-GlcNAc in AD remains elusive. O-GlcNAc cycling is facilitated by only two highly conserved enzymes: O-GlcNAc transferase (OGT) catalyzes the addition, while O-GlcNAcase (OGA) catalyzes the removal of GlcNAc from proteins. Studies analyzing global O-GlcNAc levels in AD brain have produced inconsistent results and the reasons for altered O-GlcNAcylation in AD are still poorly understood...
September 2014: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/24858682/inhibition-of-mtor-affects-protein-stability-of-ogt
#18
S Park, J Pak, I Jang, J W Cho
Autophagy regulates cellular homeostasis through degradation of aged or damaged subcellular organelles and components. Interestingly, autophagy-deficient beta cells, for example Atg7-mutant mice, exhibited hypoinsulinemia and hyperglycemia. Also, autophagy response is diminished in heart of diabetic mice. These results implied that autophagy and diabetes are closely connected and affect each other. Although protein O-GlcNAcylation is up-regulated in hyperglycemia and diabetes, and O-GlcNAcylated proteins play an important role in metabolism and nutrient sensing, little is known whether autophagy affects O-GlcNAc modification and vice versa...
October 17, 2014: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/24759912/o-glcnac-and-neurodegeneration-biochemical-mechanisms-and-potential-roles-in-alzheimer-s-disease-and-beyond
#19
REVIEW
Scott A Yuzwa, David J Vocadlo
Alzheimer disease (AD) is a growing problem for aging populations worldwide. Despite significant efforts, no therapeutics are available that stop or slow progression of AD, which has driven interest in the basic causes of AD and the search for new therapeutic strategies. Longitudinal studies have clarified that defects in glucose metabolism occur in patients exhibiting Mild Cognitive Impairment (MCI) and glucose hypometabolism is an early pathological change within AD brain. Further, type 2 diabetes mellitus (T2DM) is a strong risk factor for the development of AD...
October 7, 2014: Chemical Society Reviews
https://www.readbyqxmd.com/read/24744983/o-glcnac-cycling-shows-neuroprotective-potential-in-c-elegans-models-of-neurodegenerative-disease
#20
John A Hanover, Peng Wang
C. elegans has proven to be an excellent organism in which to model human neurodegenerative disease.(1) (-) (7) The worm's simple nervous system, lineage, and neural maps, easily scored movement phenotypes, and robust forward and reverse genetics make it optimal for studying age-dependent processes on a reasonable time scale. A popular approach has been the introduction of transgenes expressing GFP-tagged proteotoxic human proteins into neurons leading to visible aggregation or movement phenotypes.(2) (,) (4) (,) (6) (,) (8) (-) (13) In addition, the maintenance of proteostasis networks has been extensively studied using the power of worm genetics...
October 1, 2013: Worm
keyword
keyword
93892
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"