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Validation cost effectiveness simulation

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https://www.readbyqxmd.com/read/29351250/a-gps-phase-locked-loop-performance-metric-based-on-the-phase-discriminator-output
#1
Stefan Stevanovic, Boris Pervan
We propose a novel GPS phase-lock loop (PLL) performance metric based on the standard deviation of tracking error (defined as the discriminator's estimate of the true phase error), and explain its advantages over the popular phase jitter metric using theory, numerical simulation, and experimental results. We derive an augmented GPS phase-lock loop (PLL) linear model, which includes the effect of coherent averaging, to be used in conjunction with this proposed metric. The augmented linear model allows more accurate calculation of tracking error standard deviation in the presence of additive white Gaussian noise (AWGN) as compared to traditional linear models...
January 19, 2018: Sensors
https://www.readbyqxmd.com/read/29349543/saving-robots-improves-laparoscopic-performance-transfer-of-skills-from-a-serious-game-to-a-virtual-reality-simulator
#2
Wouter M IJgosse, Harry van Goor, Jan-Maarten Luursema
BACKGROUND: Residents find it hard to commit to structural laparoscopic skills training. Serious gaming has been proposed as a solution on the premise that it is effective and more motivating than traditional simulation. We establish construct validity for the laparoscopic serious game Underground by comparing laparoscopic simulator performance for a control group and an Underground training group. METHODS: A four-session laparoscopic basic skills course is part of the medical master students surgical internship at the Radboud University Medical Centre...
January 18, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29336335/-evaluation-of-competencies-in-urology-esscolap%C3%A2-basic-as-aproximation-to-urologists-skills-improvement
#3
Javier Sánchez-Fernández, Jaime Bachiller-Burgos, Alvaro Serrano-Pascual, José Manuel Cózar-Olmo, Idoia Díaz-Güemes, Miguel Angel Sánchez-Hurtado, Belén Moreno-Naranjo, Silvia Enciso-Sanz, Laura Correa-Martín, Blanca Fernández-Tomé, María Mar Pérez-López, José Luis Alvarez-Ossorio, Francisco Miguel Sánchez-Margallo
Urology needs models of competencies assessment, although there is a wide range of tools not yet integrated into the official training programs. CONTEXT: At present, there is no universal framework for measuring surgeons' level of competence. Urology training programs should provide and consider knowledge, pyschomotor/cognitive skills, and simulator, cadaver or animal models-based training. Validity is a complex concept that refers to the capacity of the evaluation tool, so it is necessary to demonstrate several types of validation to assure the capacity of a method, reinforced with different reliability tests and calculation of internal consistency between evaluators...
January 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29336065/optimization-of-18-f-syntheses-using-19-f-reagents-at-tracer-level-concentrations-and-lc-ms-ms-analysis-improved-synthesis-of-18-f-mdl100907
#4
Xiang Zhang, Ryan Dunlow, Burchelle N Blackman, Rolf E Swenson
Traditional radiosynthetic optimization faces the challenges of high radiation exposure, cost and inability to perform serial reactions due to tracer decay. To accelerate tracer development, we have developed a strategy to simulate radioactive 18 F-syntheses by using tracer-level (nanomolar) non-radioactive 19 F-reagents and LC-MS/MS analysis. The methodology was validated with fallypride synthesis under tracer-level 19 F-conditions, which showed reproducible and comparable results with radiosynthesis, and proved the feasibility of this process...
January 16, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29331740/development-and-validation-of-a-new-population-based-simulation-model-of-osteoarthritis-in-new-zealand
#5
Ross Wilson, J Haxby Abbott
OBJECTIVE: To describe the construction and preliminary validation of a new population-based microsimulation model developed to analyse the health and economic burden and cost-effectiveness of treatments for knee osteoarthritis (OA) in New Zealand (NZ). METHOD: We developed the New Zealand Management of Osteoarthritis (NZ-MOA) model, a discrete-time state-transition microsimulation model of the natural history of radiographic knee OA. In this article, we report on the model structure, derivation of input data, validation of baseline model parameters against external data sources, and validation of model outputs by comparison of the predicted population health loss with previous estimates...
January 10, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29324415/convolutional-sparse-coding-for-rgb-nir-imaging
#6
Xuemei Hu, Felix Heide, Qionghai Dai, Gordon Wetzstein
Emerging sensor designs increasingly rely on novel color filter arrays (CFAs) to sample the incident spectrum in unconventional ways. In particular, capturing a near-infrared (NIR) channel along with conventional RGB color is an exciting new imaging modality. RGB+NIR sensing has broad applications in computational photography, such as low-light denoising, it has applications in computer vision, such as facial recognition and tracking, and it paves the way toward low-cost single-sensor RGB and depth imaging using structured illumination...
April 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29300001/redesigning-existing-transcranial-magnetic-stimulation-coils-to-reduce-energy-application-to-low-field-magnetic-stimulation
#7
Boshuo Wang, Michael R Shen, Zhi-De Deng, James Evan Smith, Joseph James Tharayil, Clement J Gurrey, Luis J Gomez, Angel V Peterchev
To present a systematic framework and exemplar for the development of a compact and energy-efficient coil that replicates the electric field (E-field) distribution induced by an existing transcranial magnetic stimulation coil. Approach. The E-field generated by a conventional low field magnetic stimulation (LFMS) coil was measured for a spherical head model and simulated in both spherical and realistic head models. Then, using a spherical head model and spatial harmonic decomposition, a spherical-shaped cap coil was synthesized such that its windings conformed to a spherical surface and replicated the E-field on the cortical surface while requiring less energy...
January 4, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29297294/combining-agent-based-models-and-virtual-screening-techniques-to-predict-the-best-citrus-derived-vaccine-adjuvants-against-human-papilloma-virus
#8
Marzio Pennisi, Giulia Russo, Silvia Ravalli, Francesco Pappalardo
BACKGROUND: Human papillomavirus infection is a global social burden that, every year, leads to thousands new diagnosis of cancer. The introduction of a protocol of immunization, with Gardasil and Cervarix vaccines, has radically changed the way this infection easily spreads among people. Even though vaccination is only preventive and not therapeutic, it is a strong tool capable to avoid the consequences that this pathogen could cause. Gardasil vaccine is not free from side effects and the duration of immunity is not always well determined...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29249640/vessel-ligation-fundamentals-a-comparison-of-technical-evaluations-by-crowdsourced-nonclinical-personnel-and-surgical-faculty
#9
Yinin Hu, Boxiang Jiang, Helen Kim, Anneke T Schroen, Philip W Smith, Sara K Rasmussen
BACKGROUND: Evaluation of fundamental surgical skills is invaluable to the training of medical students and junior residents. This study assessed the effectiveness of crowdsourcing nonmedical personnel to evaluate technical proficiency at simulated vessel ligation. STUDY DESIGN: Fifteen videos were captured of participants performing vessel ligation using a low-fidelity model (5 attending surgeons and 5 medical students before and after training). These videos were evaluated by nonmedical personnel recruited through Amazon Mechanical Turk, as well as by 3 experienced surgical faculty...
December 14, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29228950/indacaterol-glycopyrronium-is-cost-effective-compared-to-salmeterol-fluticasone-in-copd-flame-based-modelling-in-a-swedish-population
#10
Leif Bjermer, Job F M van Boven, Madlaina Costa-Scharplatz, Dorothy L Keininger, Florian S Gutzwiller, Karin Lisspers, Ronan Mahon, Petter Olsson, Nicolas Roche
BACKGROUND: This study assessed the cost-effectiveness of indacaterol/glycopyrronium (IND/GLY) versus salmeterol/fluticasone (SFC) in chronic obstructive pulmonary disease (COPD) patients with moderate to very severe airflow limitation and ≥1 exacerbation in the preceding year. METHODS: A previously published and validated patient-level simulation model was adapted using clinical data from the FLAME trial and real-world cost data from the ARCTIC study. Costs (total monetary costs comprising drug, maintenance, exacerbation, and pneumonia costs) and health outcomes (life-years (LYs), quality-adjusted life-years (QALYs)) were projected over various time horizons (1, 5, 10 years, and lifetime) from the Swedish payer's perspective and were discounted at 3% annually...
December 11, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29228934/a-pilot-study-to-assess-the-utility-of-a-freely-downloadable-mobile-application-simulator-for-undergraduate-clinical-skills-training-a-single-blinded-randomised-controlled-trial
#11
Richard D Bartlett, Dina Radenkovic, Stefan Mitrasinovic, Andrew Cole, Iva Pavkovic, Peyton Cheong Phey Denn, Mahrukh Hussain, Magdalena Kogler, Natalia Koutsopodioti, Wasima Uddin, Ivan Beckley, Hana Abubakar, Deborah Gill, Daron Smith
BACKGROUND: Medical simulators offer an invaluable educational resource for medical trainees. However, owing to cost and portability restrictions, they have traditionally been limited to simulation centres. With the advent of sophisticated mobile technology, simulators have become cheaper and more accessible. Touch Surgery is one such freely downloadable mobile application simulator (MAS) used by over one million healthcare professionals worldwide. Nevertheless, to date, it has never been formally validated as an adjunct in undergraduate medical education...
December 11, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29224996/cost-effectiveness-of-the-non-laboratory-based-framingham-algorithm-in-primary-prevention-of-cardiovascular-disease-a-simulated-analysis-of-a-cohort-of-african-american-adults
#12
Jacob K Kariuki, Philimon Gona, Suzanne G Leveille, Eileen M Stuart-Shor, Laura L Hayman, Jerry Cromwell
The non-lab Framingham algorithm, which substitute body mass index for lipids in the laboratory based (lab-based) Framingham algorithm, has been validated among African Americans (AAs). However, its cost-effectiveness and economic tradeoffs have not been evaluated. This study examines the incremental cost-effectiveness ratio (ICER) of two cardiovascular disease (CVD) prevention programs guided by the non-lab versus lab-based Framingham algorithm. We simulated the World Health Organization CVD prevention guidelines on a cohort of 2690 AA participants in the Atherosclerosis Risk in Communities (ARIC) cohort...
December 7, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29198733/virtual-medicine-utilization-of-the-advanced-cardiac-imaging-patient-avatar-for-procedural-planning-and-facilitation
#13
REVIEW
Jerold S Shinbane, Leslie A Saxon
Advances in imaging technology have led to a paradigm shift from planning of cardiovascular procedures and surgeries requiring the actual patient in a "brick and mortar" hospital to utilization of the digitalized patient in the virtual hospital. Cardiovascular computed tomographic angiography (CCTA) and cardiovascular magnetic resonance (CMR) digitalized 3-D patient representation of individual patient anatomy and physiology serves as an avatar allowing for virtual delineation of the most optimal approaches to cardiovascular procedures and surgeries prior to actual hospitalization...
November 16, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29191094/potential-of-predictive-computer-models-for-preoperative-patient-selection-to-enhance-overall-quality-adjusted-life-years-gained-at-2-year-follow-up-a-simulation-in-234-patients-with-adult-spinal-deformity
#14
Taemin Oh, Justin K Scheer, Justin S Smith, Richard Hostin, Chessie Robinson, Jeffrey L Gum, Frank Schwab, Robert A Hart, Virginie Lafage, Douglas C Burton, Shay Bess, Themistocles Protopsaltis, Eric O Klineberg, Christopher I Shaffrey, Christopher P Ames
OBJECTIVE Patients with adult spinal deformity (ASD) experience significant quality of life improvements after surgery. Treatment, however, is expensive and complication rates are high. Predictive analytics has the potential to use many variables to make accurate predictions in large data sets. A validated minimum clinically important difference (MCID) model has the potential to assist in patient selection, thereby improving outcomes and, potentially, cost-effectiveness. METHODS The present study was a retrospective analysis of a multiinstitutional database of patients with ASD...
December 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29177931/evaluating-the-interaction-of-a-tracheobronchial-stent-in-an-ovine-in-vivo-model
#15
Donnacha J McGrath, Anja Lena Thiebes, Christian G Cornelissen, Barry O'Brien, Stefan Jockenhoevel, Mark Bruzzi, Peter E McHugh
Tracheobronchial stents are used to restore patency to stenosed airways. However, these devices are associated with many complications such as stent migration, granulation tissue formation, mucous plugging and stent strut fracture. Of these, granulation tissue formation is the complication that most frequently requires costly secondary interventions. In this study a biomechanical lung modelling framework recently developed by the authors to capture the lung in-vivo stress state under physiological loading is employed in conjunction with ovine pre-clinical stenting results and device experimental data to evaluate the effect of stent interaction on granulation tissue formation...
November 24, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29141153/using-observational-data-to-calibrate-simulation-models
#16
Eleanor J Murray, James M Robins, George R Seage, Sara Lodi, Emily P Hyle, Krishna P Reddy, Kenneth A Freedberg, Miguel A Hernán
BACKGROUND: Individual-level simulation models are valuable tools for comparing the impact of clinical or public health interventions on population health and cost outcomes over time. However, a key challenge is ensuring that outcome estimates correctly reflect real-world impacts. Calibration to targets obtained from randomized trials may be insufficient if trials do not exist for populations, time periods, or interventions of interest. Observational data can provide a wider range of calibration targets but requires methods to adjust for treatment-confounder feedback...
November 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29139057/cadaveric-simulation-a-review-of-reviews
#17
REVIEW
M Yiasemidou, E Gkaragkani, D Glassman, C S Biyani
BACKGROUND: Traditional surgical training, largely based on the Halstedian model "see one, do one, teach one" is not as effective in the era of working time restrictions and elaborate shift-patterns. As a result, contemporary surgeons turned to educational methods outside the operating theatre such as simulation. Cadavers are high fidelity models but their use has ethical and cost implications and their availability may be limited. In this review, we explore the role of cadaveric simulation in modern surgical education...
November 14, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29122046/model-based-cost-effectiveness-of-conventional-and-innovative-chemo-radiation-in-lung-cancer
#18
Mathilda L Bongers, Dirk de Ruysscher, Cary Oberije, Philippe Lambin, Carin A Uyl-de Groot, José Belderbos, Veerle M H Coupé
INTRODUCTION: Optimizing radiotherapy with or without chemotherapy through advanced imaging and accelerated radiation schemes shows promising results in locally advanced non-small-cell lung cancer (NSCLC). This study compared the cost-effectiveness of positron emission tomography-computed tomography based isotoxic accelerated sequential chemo-radiation (SRT2) and concurrent chemo-radiation with daily low-dose cisplatin (CRT2) with standard sequential (SRT1) and concurrent chemo-radiation (CRT1)...
November 10, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29121247/prediction-of-individual-outcomes-for-asthma-sufferers
#19
B Storlie Curtis, E Branda Megan, R Gionfriddo Michael, D Shah Nilay, A Rank Matthew
We consider the problem of individual-specific medication level recommendation (initiation, removal, increase, or decrease) for asthma sufferers. Asthma is one of the most common chronic diseases in both adults and children, affecting 8% of the US population and costing $37-63 billion/year in the United States of America. Asthma is a complex disease, whose symptoms may wax and wane, making it difficult for clinicians to predict outcomes and prognosis. Improved ability to predict prognosis can inform decision making and may promote conversations between clinician and provider around optimizing medication therapy...
November 6, 2017: Biostatistics
https://www.readbyqxmd.com/read/29102016/editorial-commentary-arthroscopic-simulation-training-need-not-be-expensive-to-be-effective
#20
EDITORIAL
Aman Dhawan
In a randomized controlled trial of arthroscopic training tools, the low-cost/low-fidelity Cigar Box Arthroscopy Trainer demonstrated equivalent efficacy to the validated, and more expensive, Anatomic Knee Arthroscopy Trainer (AKAT) in the training of novice arthroscopists using a validated scoring system, the Basic Arthroscopic Knee Skill Scoring System. As simulation training and formal surgical skills training is now mandatory, residency and fellowship programs are required to incorporate training modules and equipment to maximize learning while minimizing potential for patient harm...
November 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
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