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https://www.readbyqxmd.com/read/29458201/computer-assisted-surgery-in-acetabular-fractures-virtual-reduction-of-acetabular-fracture-using-the-first-patient-specific-biomechanical-model-simulator
#1
M Boudissa, H Oliveri, M Chabanas, J Tonetti
Preoperative planning for the management of acetabular fracture is founded on geometric models allowing virtual repositioning of the bone fragments, but not taking account of soft tissue and the realities of the surgical procedure. The present technical note reports results using the first simulator to be based on a patient-specific biomechanical model, simulating the action of forces on the fragments and also the interactions between soft issue and bone: muscles, capsules, ligaments, and bone contacts. In all 14 cases, biomechanical simulation faithfully reproduced the intraoperative behavior of the various bone fragments and reduction quality...
February 16, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29457758/appraising-cervical-mucus-a-new-approach-to-evaluating-contraceptives
#2
Leo Han, Emily Padua, Alison Edelman, Jeffrey T Jensen
PURPOSE: Timing of sample collection represents a major source of variability in studies evaluating the effects of administered agents on cervical mucus in naturally-cycling women. We sought to create and validate an artificial model of the cervical mucus cycle using exogenous E2 and P4 replacement in ovarian suppressed women. MATERIALS AND METHODS: We conducted a prospective experiment (clinicaltrials.gov, NCT02969590) examining cervical mucus changes in six women during natural and artificial menstrual cycles [leuprolide acetate, estradiol transdermal patch (0...
February 19, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29457655/importance-of-growth-rate-on-hg-and-pcb-bioaccumulation-in-fish
#3
Jiajia Li, G Douglas Haffner, Gordon Paterson, David M Walters, Michael D Burtnyk, Ken G Drouillard
To evaluate the effect of fish growth on mercury (Hg) and polychlorinated biphenyls (PCBs) bioaccumulation, a non-steady state toxicokinetic model, combined with a Wisconsin bioenergetics model, was developed to simulate Hg and PCB bioaccumulation in Bluegill (Lepomis macrochirus). The model was validated by comparing observed versus predicted Hg and PCB 180 concentrations across 5 age classes from five different waterbodies across North America. The non-steady state model generated accurate predictions for Hg and PCB bioaccumulation in three of five waterbodies: Apsey, Sharbot and Stonelick Lake...
February 19, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29457371/validation-of-a-blood-marker-for-plasma-volume-in-endurance-athletes-during-a-live-high-train-low-altitude-training-camp
#4
Louisa M Lobigs, Laura A Garvican-Lewis, Victor L Vuong, Nicolin Tee, Christopher J Gore, Peter Peeling, Brian Dawson, Yorck O Schumacher
Altitude is a confounding factor within the Athlete's Biological Passport (ABP) due, in part, to the plasma volume (PV) response to hypoxia. Here, a newly developed PV blood test is applied to assess the possible efficacy of reducing the influence of PV on the volumetric ABP markers; hemoglobin concentration ([Hb]) and the OFF-score. Endurance athletes (n=34) completed a 21 night simulated live high: train low protocol (14h.d-1 at 3000m). Bloods were collected twice pre-altitude, at days 3, 8 and 15 at altitude and 1, 7, 21 and 42 days post-altitude...
February 19, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29457313/modeling-the-hematocrit-distribution-in-microcirculatory-networks-a-quantitative-evaluation-of-a-phase-separation-model
#5
Peter M Rasmussen, Timothy W Secomb, Axel R Pries
OBJECTIVE: Theoretical models are essential tools for studying microcirculatory function. Recently, the validity of a well-established phase separation model was questioned and it was claimed that it produces problematically low hematocrit predictions and lack of red cells in small diameter vessels. We conducted a quantitative evaluation of this phase separation model to establish common ground for future research. METHODS: Model predictions were validated against a comprehensive data base with measurements from four mesenteric networks...
February 19, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29456913/investigating-the-7-year-cost-effectiveness-of-single-level-cervical-disc-replacement-compared-to-anterior-cervical-discectomy-and-fusion
#6
Steven J McAnany, Robert K Merrill, Samuel C Overley, Jun S Kim, Robert L Brochin, Sheeraz A Qureshi
Study Design: Cost-effectiveness analysis. Objectives: To determine the 7-year cost-effectiveness of cervical disc replacement (CDR) and anterior cervical discectomy and fusion (ACDF). Methods: We analyzed 7-year Short Form-36 Health Survey data collected from the Prestige Cervical Disc investigational device exemption study (IDE). The SF-6D algorithm was used to convert this data into health state utilities. Costs were calculated from the payer perspective, and quality adjusted life years (QALYs) were used to represent effectiveness...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456895/calibration-adjustments-to-address-bias-in-mortality-analyses-due-to-informative-sampling-a-census-linked-survey-analysis-in-switzerland
#7
André Moser, Matthias Bopp, Marcel Zwahlen
Background: Sampling bias, like survey participants' nonresponse, needs to be adequately addressed in the analysis of sampling designs. Often survey weights will be calibrated on specific covariates related to the probability of selection and nonresponse to get representative population estimates. However, such calibrated survey (CS) weights are usually constructed for cross-sectional results, but not for longitudinal analyses. For example, when the outcome of interest is time to death, and sampling selection is related to time to death and censoring, sampling is informative...
2018: PeerJ
https://www.readbyqxmd.com/read/29456389/assessment-of-quality-of-prescription-writing-among-dental-and-medical-students-and-practitioners-in-kerala
#8
Naveen Jacob Varghese, Venkitachalam Ramanarayanan, Chandrashekar Janakiram, Joe Joseph
Background: The medical prescription is a valid and legal document. Prescriptions can also be used as a measure of the quality of medical education, observance of the laws and regulations, and sociocultural beliefs. Aims: To assess the quality of prescription written by dental and medical students and practitioners. Settings and Design: A cross-sectional study was conducted in three dental and two medical colleges in Kerala covering 345 participants (dental - 235 and medical - 110)...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29456259/improvement-of-electromagnetic-field-distributions-using-high-dielectric-constant-hdc-materials-for-ctl-spine-mri-numerical-simulations-and-experiments
#9
Bu S Park, Brent McCright, Leonardo M Angelone, Amir Razjouyan, Sunder S Rajan
This study investigates the use of pads with high dielectric constant (HDC) materials to alter electromagnetic field distributions in patients during magnetic resonance imaging (MRI). The study was performed with numerical simulations and phantom measurements. An initial proof-of-concept and validation was performed using a phantom at 64 MHz, showing increases of up to 10% in electromagnetic field when using distilled water as the high dielectric material. Additionally, numerical simulations with computational models of human anatomy were performed at 128 MHz...
October 2017: IEEE Transactions on Electromagnetic Compatibility
https://www.readbyqxmd.com/read/29456172/effect-of-pediatric-growth-on-cervical-spine-kinematics-and-deformations-in-automotive-crashes
#10
Victor S Alvarez, Svein Kleiven
Finite element (FE) models are a powerful tool that can be used to understand injury mechanisms and develop better safety systems. This study aims to extend the understanding of pediatric spine biomechanics, where there is a paucity of studies available. A newly developed and continuously scalable FE model was validated and scaled to 1.5-, 3-, 6-, 10-, 14- and 18-year-old using a non-linear scaling technique, accounting for local topological changes. The oldest and youngest ages were also scaled using homogeneous geometric scaling...
February 8, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29455536/resveratrol-s-hidden-hand-a-route-to-optical-detection-of-biomolecular-binding
#11
Subhojyoti Chatterjee, Seth Olsen, Ewan W Blanch, Feng Wang
Resveratrol (RSVL) is a stilbenoid phytoalexin with promised myriad health benefits predominantly attributed to the trans (E) diastereomeric form. A recent study has implicated the Z (cis) diastereomer in human health. This stereoisomer binds with high affinity to human tyrosyl-tRNA synthetase, initiating a downstream cascade that promotes the expression of genes associated with the cellular stress response. We discovered that the non-planar structure of cis-resveratrol conformer possesses certain chiral signals in its simulated vibrational circular dichroism (VCD) and Raman optical activity (ROA) spectra...
February 17, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29455040/a-simple-method-for-calculating-the-likelihood-ratio-in-a-kinship-test-using-x-chromosomal-markers-incorporating-linkage-linkage-disequilibrium-and-mutation
#12
Mamiko Fukuta, Mohammed Hassan Gaballah, Hideaki Kato, Yasuhiro Aoki
X-chromosomal short tandem repeats (X-STRs) are useful for personal identification and kinship tests. However, it has not yet been fully established how to incorporate linkage and linkage disequilibrium (LD) into the calculation of the likelihood ratio (LR). In this paper, we describe a simple calculation method of LR for X-STRs that incorporated linkage, LD, and mutations. Initially, Japanese population data of 27 X-STRs (DXS6807, DXS9902, DXS6795, DXS6810, DXS10076, DXS10077, DXS10078, DXS10162, DXS10163, DXS10164, DXS7132, DXS981, DXS6800, DXS6803, DXS6809, DXS6789, DXS6799, DXS7424, DXS101, DXS7133, GATA172D05, DXS10103, HPRTB, GATA31E08, DXS8377, DXS10147, and DXS7423) were collected from 748 unrelated individuals to estimate the influence of LD...
February 12, 2018: Legal Medicine
https://www.readbyqxmd.com/read/29454600/new-methods-to-assess-forearm-torque-and-lifting-strength-reliability-and-validity
#13
Peter Axelsson, Johan Kärrholm
PURPOSE: To determine the repeatability and validity of new methods designed to objectively measure forearm torque and lifting strength in a clinical setting. METHODS: Twenty-eight healthy volunteers, 19 women and 9 men, were tested for lifting strength and forearm torque with the Kern and Baseline dynamometers. Two raters tested each participant on 3 occasions in the standing position. One of the raters also examined 15 subjects, 3 times, for forearm torque in the seated position and for lifting strength and forearm torque by the Work Simulator II, Baltimore Therapeutic Equipment (BTE II)...
February 14, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29454530/system-dynamics-model-of-taxi-management-in-metropolises-economic-and-environmental-implications-for-beijing
#14
Hao Wang, Kai Zhang, Junhua Chen, Zhifeng Wang, Guijun Li, Yuqi Yang
Taxis are an important component of urban passenger transport. Research on the daily dispatching of taxis and the utility of governmental management is important for the improvement of passenger travel, taxi driver income and environmental impacts. However, urban taxi management is a complex and dynamic system that is affected by many factors, and positive/negative feedback relationships and nonlinear interactions exist between each subsystem and variable. Therefore, conventional research methods can hardly depict its characteristics comprehensively...
February 14, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29454111/combining-rosetta-with-molecular-dynamics-md-a-benchmark-of-the-md-based-ensemble-protein-design
#15
Jan Ludwiczak, Adam Jarmula, Stanislaw Dunin-Horkawicz
Computational protein design is a set of procedures for computing amino acid sequences that will fold into a specified structure. Rosetta Design, a commonly used software for protein design, allows for the effective identification of sequences compatible with a given backbone structure, while molecular dynamics (MD) simulations can thoroughly sample near-native conformations. We benchmarked a procedure in which Rosetta design is started on MD-derived structural ensembles and showed that such a combined approach generates 20 to 30% more diverse sequences than currently available methods with only a slight increase in computation time...
February 14, 2018: Journal of Structural Biology
https://www.readbyqxmd.com/read/29453930/ensemble-survival-tree-models-to-reveal-pairwise-interactions-of-variables-with-time-to-events-outcomes-in-low-dimensional-setting
#16
Jean-Eudes Dazard, Hemant Ishwaran, Rajeev Mehlotra, Aaron Weinberg, Peter Zimmerman
Unraveling interactions among variables such as genetic, clinical, demographic and environmental factors is essential to understand the development of common and complex diseases. To increase the power to detect such variables interactions associated with clinical time-to-events outcomes, we borrowed established concepts from random survival forest (RSF) models. We introduce a novel RSF-based pairwise interaction estimator and derive a randomization method with bootstrap confidence intervals for inferring interaction significance...
February 17, 2018: Statistical Applications in Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29453185/air-quality-impacted-by-local-pollution-sources-and-beyond-using-a-prominent-petro-industrial-complex-as-a-study-case
#17
Sheng-Po Chen, Chieh-Heng Wang, Wen-Dian Lin, Yu-Huei Tong, Yu-Chun Chen, Ching-Jui Chiu, Hung-Chi Chiang, Chen-Lun Fan, Jia-Lin Wang, Julius S Chang
The present study combines high-resolution measurements at various distances from a world-class gigantic petrochemical complex with model simulations to test a method to assess industrial emissions and their effect on local air quality. Due to the complexity in wind conditions which were highly seasonal, the dominant wind flow patterns in the coastal region of interest were classified into three types, namely northeast monsoonal (NEM) flows, southwest monsoonal (SEM) flows and local circulation (LC) based on six years of monitoring data...
February 13, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29453025/material-properties-of-the-brain-in-injury-relevant-conditions-experiments-and-computational-modeling
#18
Wei Zhao, Bryan Choate, Songbai Ji
Material properties of the brain have been extensively studied but remain poorly characterized. The vast variations in constitutive models and material constants are well documented. However, no study exists to translate the variations into disparities in impact-induced brain strains most relevant to brain injury. Here, we reviewed a subset of injury-relevant brain material properties either characterized in experiments or adopted in recent head injury models. To highlight how variations in measured brain material properties manifested in simulated brain strains, we selected six experiments that have provided a complete set of brain material model and constants to implement a common head injury model...
February 6, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29451998/predicting-the-integrated-visual-field-with-wide-scan-optical-coherence-tomography-in-glaucoma-patients
#19
Masaaki Yoshida, Shiho Kunimatsu-Sanuki, Kazuko Omodaka, Toru Nakazawa
PURPOSE: This study aimed to calculate a predicted integrated visual field (IVF) based on predicted monocular visual fields (MVFs) derived, with a new method, from wide-scan optical coherence tomography (OCT) data. MATERIALS AND METHODS: Visual field testing used the central (6 × 4) 24 points of the Humphrey Field Analyzer 24-2 program. OCT scans of a corresponding retinal area, centered on the fovea, were divided into a 6 × 4 grid. The thickness of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer + inner plexiform layer (GCIPL), and mRNFL + GCIPL (GCC) was measured in each grid area...
February 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29451873/in-silico-analysis-of-antibiotic-induced-clostridium-difficile-infection-remediation-techniques-and-biological-adaptations
#20
Eric W Jones, Jean M Carlson
In this paper we study antibiotic-induced C. difficile infection (CDI), caused by the toxin-producing C. difficile (CD), and implement clinically-inspired simulated treatments in a computational framework that synthesizes a generalized Lotka-Volterra (gLV) model with SIR modeling techniques. The gLV model uses parameters derived from an experimental mouse model, in which the mice are administered antibiotics and subsequently dosed with CD. We numerically identify which of the experimentally measured initial conditions are vulnerable to CD colonization, then formalize the notion of CD susceptibility analytically...
February 16, 2018: PLoS Computational Biology
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