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https://www.readbyqxmd.com/read/28346013/the-physiology-of-blood-loss-and-shock-new-insights-from-a-human-laboratory-model-of-hemorrhage
#1
Alicia M Schiller, Jeffrey T Howard, Victor A Convertino
The ability to quickly diagnose hemorrhagic shock is critical for favorable patient outcomes. Therefore, it is important to understand the time course and involvement of the various physiological mechanisms that are active during volume loss and that have the ability to stave off hemodynamic collapse. This review provides new insights about the physiology that underlies blood loss and shock in humans through the development of a simulated model of hemorrhage using lower body negative pressure. In this review, we present controlled experimental results through utilization of the lower body negative pressure human hemorrhage model that provide novel insights on the integration of physiological mechanisms critical to the compensation for volume loss...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28345437/clinical-profile-dosing-and-quality-of-life-outcomes-in-primary-immune-deficiency-patients-treated-at-home-with-immunoglobulin-g-data-from-the-ideal-patient-registry
#2
Sean Kearns, Loretta Kristofek, William Bolgar, Luqman Seidu, Samantha Kile
BACKGROUND: Patients with primary immune deficiency (PID) often require immunoglobulin G (IgG, commonly referred to as Ig) replacement therapy to prevent infections and associated comorbidities. Ig therapy can be given either through intravenous or subcutaneous routes, and both can be done in the home setting. There is limited information available on the real-world diagnosis, management, and outcomes of this patient population, given the variable disease presentation and treatment options...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28340603/blunt-cardiac-injury-due-to-trauma-associated-with-snowboarding-a-case-report
#3
Fuminori Yamaji, Hideshi Okada, Yasuhiro Nakajima, Kodai Suzuki, Takahiro Yoshida, Yosuke Mizuno, Haruka Okamoto, Yuichiro Kitagawa, Taku Tanaka, Shiho Nakano, Sho Nachi, Tomoaki Doi, Keisuke Kumada, Shozo Yoshida, Narihiro Ishida, Katsuya Shimabukuro, Hiroaki Ushikoshi, Izumi Toyoda, Kiyoshi Doi, Shinji Ogura
BACKGROUND: Cardiac trauma is associated with a much higher mortality rate than injuries to other organ systems, even though cardiac trauma is identified in less than 10% of all trauma admissions. Here we report blunt trauma of the left atrium due to snowboarding trauma. CASE PRESENTATION: A 45-year-old Asian man collided with a tree while he was snowboarding and drinking. He lost consciousness temporarily. An air ambulance was requested and he was transported to an advanced critical care center...
March 25, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28339299/the-10th-gcc-closed-forum-rejected-data-gcp-in-bioanalysis-extract-stability-bav-processed-batch-acceptance-matrix-stability-critical-reagents-eln-and-data-integrity-and-counteracting-fraud
#4
Stephanie Cape, Rafiq Islam, Corey Nehls, John Allinson, Afshin Safavi, Patrick Bennett, James Hulse, Chris Beaver, Masood Khan, Shane Karnik, Maria Cruz Caturla, Steve Lowes, Adriana Iordachescu, Luigi Silvestro, Rabab Tayyem, Ron Shoup, Stephanie Mowery, Anahita Keyhani, Andrea Wakefield, Yinghe Li, Jennifer Zimmer, Javier Torres, Philippe Couerbe, Ardeshir Khadang, James Bourdage, Nicola Hughes, Kayode Awaiye, Brent Matthews, Saadya Fatmi, Rhonda Johnson, Christina Satterwhite, Mathilde Yu, Jenny Lin, Laura Cojocaru, Michele Fiscella, Eric Thomas, Kai Kurylak, John Kamerud, Zhongping John Lin, Wei Garofolo, Natasha Savoie, Mike Buonarati, Nadine Boudreau, Clark Williard, Yansheng Liu, Dominic Warrino, Prashant Kale, Neil Adcock, Radha Shekar, Edward O'Connor, Hanna Ritzen, Christina Sanchez, Roger Hayes, Mohammed Bouhajib, Simona Rizea Savu, Bruce Stouffer, Edward Tabler, Jing Tu, Chad Briscoe, Barry van der Strate, Paul Rhyne, Phyllis Conliffe, Ira DuBey, Jim Yamashita, Daniel Tang, Elizabeth Groeber, Jenifer Vija, Michele Malone, Mohamed Osman
The 10th Global CRO Council (GCC) Closed Forum was held in Orlando, FL, USA on 18 April 2016. In attendance were decision makers from international CRO member companies offering bioanalytical services. The objective of this meeting was for GCC members to meet and discuss scientific and regulatory issues specific to bioanalysis. The issues discussed at this closed forum included reporting data from failed method validation runs, GCP for clinical sample bioanalysis, extracted sample stability, biomarker assay validation, processed batch acceptance criteria, electronic laboratory notebooks and data integrity, Health Canada's Notice regarding replicates in matrix stability evaluations, critical reagents and regulatory approaches to counteract fraud...
March 24, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28337082/pharmacokinetics-of-peramivir-in-an-adolescent-patient-receiving-continuous-venovenous-hemodiafiltration
#5
Ryan C Dillon, Robert Witcher, Jeffrey J Cies, Wayne S Moore, Arun Chopra
Critically ill patients requiring renal replacement therapy commonly experience pharmacokinetic alterations. This case report describes the pharmacokinetics of peramivir (Rapivab, BioCryst Pharmaceuticals, Inc, Durham, NC), the first US Food and Drug Administration-approved intravenous neuraminidase inhibitor for the treatment of influenza, in an adolescent patient receiving continuous renal replacement therapy (CRRT). A 49.5-kg, 17-year-old Caucasian female presented with fever, cough, and persistent hypoxia...
January 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28333189/fully-automated-disc-diffusion-for-rapid-antibiotic-susceptibility-test-results-a-proof-of-principle-study
#6
Michael Hombach, Marion Jetter, Nicolas Blöchliger, Natalia Kolesnik-Goldmann, Erik C Böttger
Background: Antibiotic resistance poses a significant threat to patients suffering from infectious diseases. Early readings of antibiotic susceptibility test (AST) results could be of critical importance to ensure adequate treatment. Disc diffusion is a well-standardized, established and cost-efficient AST procedure; however, its use in the clinical laboratory is hampered by the many manual steps involved, and an incubation time of 16-18 h, which is required to achieve reliable test results...
February 17, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28333044/effects-of-c-n-ratio-on-nitrous-oxide-production-from-nitrification-in-a-laboratory-scale-biological-aerated-filter-reactor
#7
Qiang He, Yinying Zhu, Leilei Fan, Hainan Ai, Xiaoliu Huangfu, Mei Chen
Emission of nitrous oxide (N2O) during biological wastewater treatment is of growing concern. This paper reports findings of the effects of carbon/nitrogen (C/N) ratio on N2O production rates in a laboratory-scale biological aerated filter (BAF) reactor, focusing on the biofilm during nitrification. Polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) and microelectrode technology were utilized to evaluate the mechanisms associated with N2O production during wastewater treatment using BAF...
March 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28328525/moving-sum-of-number-of-positive-patient-result-as-a-quality-control-tool
#8
Jiakai Liu, Chin Hon Tan, Tony Badrick, Tze Ping Loh
BACKGROUND: Recently, the total prostate-specific antigen (PSA) assay used in a laboratory had a positive bias of 0.03 μg/L, which went undetected. Consequently, a number of post-prostatectomy patients with previously undetectable PSA concentrations (defined as <0.03 μg/L in that laboratory) were being reported as having detectable PSA, which suggested poorer prognosis according to clinical guidelines. METHODS: Through numerical simulations, we explored (1) how a small bias may evade the detection of routine quality control (QC) procedures with specific reference to the concentration of the QC material, (2) whether the use of 'average of normals' approach may detect such a small bias, and (3) describe the use of moving sum of number of patient results with detectable PSA as an adjunct QC procedure...
March 22, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28315931/polycyclic-aromatic-hydrocarbons-in-mussels-from-a-south-american-estuary
#9
Ana L Oliva, Andrés H Arias, Pamela Y Quintas, Natalia S Buzzi, Jorge E Marcovecchio
Bivalves, especially mussels, have been pointed as putative species to monitor polycyclic aromatic hydrocarbons (PAHs) in marine environment. After several environmental PAHs baseline reports, the present study was conducted to assess for the first time the levels of PAHs in native mussels (Brachidontes rodriguezii) collected from a critical industrialized estuary of Argentina. Under this objective, after an 18-month sampling period, 34 pools of mussels were assessed for 17 PAHs, including the 16 compounds prioritized by United States Environmental Protection Agency...
March 18, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28304413/carbon-nanotube-thin-film-transistors-fabricated-by-an-etching-based-manufacturing-compatible-process
#10
Boyuan Tian, Xuelei Liang, Jiye Xia, Han Zhang, Guodong Dong, Qi Huang, Lianmao Peng, Sishen Xie
Carbon nanotube thin film transistors (CNT-TFTs) have been regarded as strong competitors to currently commercialized TFT technologies. Though much progress has been achieved recently, CNT-TFT research is still in the stage of laboratory research. One critical challenge for commercializing CNT-TFT technology is that the commonly used device fabrication method is a lift-off based process, which is not suitable for mass production. In this paper, we report an etching based fabrication process for CNT-TFTs, which is fully manufacturing compatible...
March 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28299848/specimen-identification-errors-in-breast-biopsies-age-matters-report-of-two-near-miss-events-and-review-of-the-literature
#11
Gary Tozbikian, Mary L Gemignani, Edi Brogi
The consequences of patient identification errors due to specimen mislabeling can be deleterious. We describe two near-miss events involving mislabeled breast specimens from two patients who sought treatment at our institution. In both cases, microscopic review of the slides identified inconsistencies between the histologic findings and patient age, unveiling specimen identification errors. By correlating the clinical information with the microscopic findings, we identified mistakes that had occurred at the time of specimen accessioning at the original laboratories...
March 16, 2017: Breast Journal
https://www.readbyqxmd.com/read/28299288/food-safety-and-sustainable-nutrition-workshops-educational-experiences-for-primary-school-children-in-turin-italy
#12
Amaranta Traversa, Daniela Adriano, Alberto Bellio, Daniela Manila Bianchi, Silvia Gallina, Clara Ippolito, Angelo Romano, Paola Durelli, Andrea Pezzana, Lucia Decastelli
European control and prevention policies are focused to guarantee a high level of protection of consumers' health. Food-borne diseases as obesity, diabetes, food allergy, and food-borne outbreaks are increasing. To prevent food-borne diseases, it is fundamental to involve consumers, in particular children, in educational experiences aimed to learn the proper behaviours to be applied. In this context, we designed and performed 5 educational workshops about food safety, hidden allergens in food and nutrition aimed to involve children attending primary and summer school...
January 24, 2017: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/28290770/in-vivo-characterization-of-cyp2d6-12-29-and-84-using-dextromethorphan-as-a-probe-drug-a-case-report
#13
Andrea Gaedigk, Greyson P Twist, Emily G Farrow, Jennifer A Lowry, Sarah E Soden, Neil A Miller
CYP2D6*84 was first described in a Black South African subject, however, its function remains unknown. Astrolabe, a probabilistic scoring tool developed in our laboratory to call genotypes from whole genome sequence, identified CYP2D6*84 in a trio. The father presented with intermediate metabolism when challenged with the CYP2D6 probe drug dextromethorphan (DM/dextrorphan [DX] = 0.0839). Since his second allele, CYP2D6*12, is nonfunctional, the observed activity is derived by CYP2D6*84. This finding suggests that the allele's hallmark P267H causes decreased activity toward DM and that this allele should receive a value of 0...
March 14, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28278743/networks-of-self-defining-memories-as-a-contributing-factor-to-emotional-openness
#14
Iliane Houle, Frederick L Philippe, Serge Lecours, Josiane Roulez
Emotional openness is characterised by a capacity to tolerate threatening self-relevant material and an interest towards new emotional situations. We investigated how specific networks of memories could be an important contributing factor to emotional openness. At Phase 1, participants completed measures of personality traits and emotional intelligence, described a self-defining memory, provided other memories associated with it, and rated the valence of each of their memories. A score assessing the complexity of this memory network, comprising the number of memories reported and their valence diversity, was created...
February 6, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28267592/sfrp4-signalling-of-apoptosis-and-angiostasis-uses-nitric-oxide-cgmp-permeability-axis-of-endothelium
#15
Uttara Saran, Mani Krishna Priya, Uma Maheswari Balaguru, Akila Swaminathan, Shunmugam Nagarajan, Arun Dharmarajan, Suvro Chatterjee
Nitric oxide (NO) plays a critical role in endothelial functions such as cellular migration, vascular permeability and angiogenesis. Angiogenesis, the formation of new blood vessels from "pre-existing" ones is a carefully regulated process and essential during reproduction, development and wound healing. Previously our lab group reported that Secreted Frizzled-Related Protein 4 (sFRP4) could inhibit angiogenesis in both in vitro and in vivo conditions. sFRP4 belongs to a family of secreted glycoproteins that function as antagonists of the canonical Wnt signalling pathway...
March 3, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28266288/parathyroid-adenomas-in-adults-and-adolescents-critical-appraisal-and-surgical-strategy-in-18-cases
#16
Mihai Radu Diaconescu, Ioan Costea, Mihai Glod, Radu Terinte, Smaranda Diaconescu
Background: Our study underline scarcity of isolated case reports or small case series of parathyroid adenoma (PA) published in autochthonous medical literature,their variable clinical expression among the "historic" varieties but also the diagnostic difficulties and delays of diagnosis as well consecration of surgery as the golden therapeutic standard of this disorder. PATIENTS AND METHOD: Demographic, clinical presentations, laboratory and imaging data, operative findings and procedures together with pathology account and outcome from the case reports of 18 patients with documented PHP were retrospectively analyzed...
January 2017: Chirurgia
https://www.readbyqxmd.com/read/28266240/replication-and-innovation-versus-a-perfect-05
#17
Joseph B Hopfinger
Slotnick (2017) makes a strong case that any attempt to assess the reliabiltiy of statistical correction procedures should use truly random data. In addition, however, there is an important side effect of the over-reliance on any given threshold to determine the worth of an experiment. Placing too much faith in any method of correction obscures the point that replication across labs remains a most critical part of scientific study. Especially for expensive methods, such as fMRI, an overemphasis on increasingly conservative thresholds can negatively impact the potential for replication of studies and the pursuit and reporting of innovative results...
March 7, 2017: Cognitive Neuroscience
https://www.readbyqxmd.com/read/28263758/don-t-fear-fear-conditioning-methodological-considerations-for-the-design-and-analysis-of-studies-on-human-fear-acquisition-extinction-and-return-of-fear
#18
REVIEW
Tina B Lonsdorf, Mareike M Menz, Marta Andreatta, Miguel A Fullana, Armita Golkar, Jan Haaker, Ivo Heitland, Andrea Hermann, Manuel Kuhn, Onno Kruse, Shira Meir Drexler, Ann Meulders, Frauke Nees, Andre Pittig, Jan Richter, Sonja Römer, Youssef Shiban, Anja Schmitz, Benjamin Straube, Bram Vervliet, Julia Wendt, Johanna M P Baas, Christian J Merz
The so-called 'replicability crisis' has sparked methodological discussions in many areas of science in general, and in psychology in particular. This has led to recent endeavours to promote the transparency, rigour, and ultimately, replicability of research. Originating from this zeitgeist, the challenge to discuss critical issues on terminology, design, methods, and analysis considerations in fear conditioning research is taken up by this work, which involved representatives from fourteen of the major human fear conditioning laboratories in Europe...
March 3, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28259258/optimal-culture-conditions-are-critical-for-efficient-expansion-of-human-testicular-somatic-and-germ-cells-in%C3%A2-vitro
#19
Itai Gat, Leila Maghen, Melissa Filice, Brandon Wyse, Khaled Zohni, Keith Jarvi, Kirk C Lo, Andrée Gauthier Fisher, Clifford Librach
OBJECTIVE: To optimize culture conditions for human testicular somatic cells (TSCs) and spermatogonial stem cells. DESIGN: Basic science study. SETTING: Urology clinic and stem cell research laboratory. PATIENT(S): Eight human testicular samples. INTERVENTIONS(S): Testicular tissues were processed by mechanical and enzymatic digestion. Cell suspensions were subjected to differential plating (DP) after which floating cells (representing germ cells) were removed and attached cells (representing TSCs) were cultured for 2 passages (P0-P1) in StemPro-34- or DMEM-F12-based medium...
March 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28257921/toward-effective-design-and-adoption-of-catalyst-based-filter-for-indoor-hazards-formaldehyde-abatement-under-realistic-conditions
#20
Kwang Hoon Han, Jensen S Zhang, Bing Guo
Catalytic oxidation at ambient temperature has drawn wide attention as a new promising method of air cleaning, converting hazardous materials into non-hazardous ones. However, limited information is available regarding catalytic filter performance/characteristics under real operating conditions, especially on service efficiency and byproducts. Also, no practical scale-up method/evidence for filter performance evaluation is currently available to scale-up laboratory results to real application conditions. These limitations and knowledge gaps prevent building owners/designers from adopting this new promising technique in their commercial/industrial applications...
February 21, 2017: Journal of Hazardous Materials
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