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Critical lab reports

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https://www.readbyqxmd.com/read/28526608/microrna-analysis-of-taenia-crassiceps-cysticerci-under-praziquantel-treatment-and-genome-wide-identification-of-taenia-solium-mirnas
#1
Matías Gastón Pérez, Natalia Macchiaroli, Gabriel Lichtenstein, Gabriela Conti, Sebastián Asurmendi, Diego Humberto Milone, Georgina Stegmayer, Laura Kamenetzky, Marcela Cucher, Mara Cecilia Rosenzvit
MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as important regulators of gene expression and perform critical functions in development and disease. In spite of the increased interest in miRNAs from helminth parasites, no information is available on miRNAs from Taenia solium, the causative agent of cysticercosis, a neglected disease affecting millions of people worldwide. Here we performed a comprehensive analysis of miRNAs from Taenia crassiceps, a laboratory model for T. solium studies, and identified miRNAs in the T...
May 16, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28521004/guidelines-for-the-prevention-and-treatment-of-travelers-diarrhea-a-graded-expert-panel-report
#2
Mark S Riddle, Bradley A Connor, Nicholas J Beeching, Herbert L DuPont, Davidson H Hamer, Phyllis Kozarsky, Michael Libman, Robert Steffen, David Taylor, David R Tribble, Jordi Vila, Philipp Zanger, Charles D Ericsson
Background: : Travelers' diarrhea causes significant morbidity including some sequelae, lost travel time and opportunity cost to both travelers and countries receiving travelers. Effective prevention and treatment are needed to reduce these negative impacts. Methods: : This critical appraisal of the literature and expert consensus guideline development effort asked several key questions related to antibiotic and non-antibiotic prophylaxis and treatment, utility of available diagnostics, impact of multi-drug resistant (MDR) colonization associated with travel and travelers' diarrhea, and how our understanding of the gastrointestinal microbiome should influence current practice and future research...
April 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28520977/asynchronous-automated-electronic-laboratory-result-notifications-a-systematic-review
#3
Benjamin H Slovis, Thomas A Nahass, Hojjat Salmasian, Gilad Kuperman, David K Vawdrey
Objective: To systematically review the literature pertaining to asynchronous automated electronic notifications of laboratory results to clinicians. Methods: PubMed, Web of Science, and the Cochrane Collaboration were queried for studies pertaining to automated electronic notifications of laboratory results. A title review was performed on the primary results, with a further abstract review and full review to produce the final set of included articles. Results: The full review included 34 articles, representing 19 institutions...
May 18, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28511718/simultaneous-development-of-kawasaki-disease-following-acute-human-adenovirus-infection-in-monozygotic-twins-a-case-report
#4
Sayaka Fukuda, Shuichi Ito, Maya Fujiwara, Jun Abe, Nozomu Hanaoka, Tsuguto Fujimoto, Hiroshi Katsumori
BACKGROUND: The etiology of Kawasaki disease (KD) remains unknown. However, many studies have suggested that specific genetic factors and/or some infectious agents underlie the onset of KD. Previous studies have suggested that human adenovirus (HAdV) is one of the triggering pathogens of KD. Here, we report monozygotic twin boys who sequentially developed KD in conjunction with acute HAdV type 3 (HAdV-3) infection. CASE PRESENTATION: The patients were four-year-old monozygotic twin boys...
May 16, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28509776/hyperleukocytosis-complicated-by-intracerebral-hemorrhage-and-spurious-hypoxemia-a-case-report-and-literature-review
#5
Yumi Katakura, Yoshikazu Yamaguchi, Tetsuya Miyashita, Masafumi Idei, Tasuku Yoshida, Yuko Matsuda, Shunsuke Takaki, Aki Kamijo, Osamu Yamaguchi, Takahisa Goto
We present the management of a 15-year-old girl with acute myeloid leukemia who presented with massive hyperleukocytosis and neurological deficit due to intracerebral hemorrhage. Surgical intervention was considered but ultimately not undertaken because of the presence of massive hyperleukocytosis, thrombocytopenia, hypokalemia, and considerable discrepancy between the oxygen saturation values determined mechanically and by peripheral oximetry. Aggressive treatment of the hyperleukocytosis was immediately started, which improved the patient's overall condition and rendered surgical intervention unnecessary...
May 12, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28503187/worker-reproduction-of-the-invasive-yellow-crazy-ant-anoplolepis-gracilipes
#6
Ching-Chen Lee, Hirotaka Nakao, Shu-Ping Tseng, Hung-Wei Hsu, Gwo-Li Lin, Jia-Wei Tay, Johan Billen, Fuminori Ito, Chow-Yang Lee, Chung-Chi Lin, Chin-Cheng Scotty Yang
BACKGROUND: Reproductive division of labor is one of the key features of social insects. Queens are adapted for reproduction while workers are adapted for foraging and colony maintenance. In many species, however, workers retain functional ovaries and can lay unfertilized male eggs or trophic eggs. Here we report for the first time on the occurrence of physogastric workers and apparent worker reproduction in the invasive yellow crazy ant Anoplolepis gracilipes (Fr. Smith). We further examined the reproductive potential and nutritional role of physogastric workers through multidisciplinary approaches including morphological characterization, laboratory manipulation, genetic analysis and behavioral observation...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28498701/fast-low-to-high-confinement-mode-bifurcation-dynamics-in-a-tokamak-edge-plasma-gyrokinetic-simulation
#7
C S Chang, S Ku, G R Tynan, R Hager, R M Churchill, I Cziegler, M Greenwald, A E Hubbard, J W Hughes
Transport barrier formation and its relation to sheared flows in fluids and plasmas are of fundamental interest in various natural and laboratory observations and of critical importance in achieving an economical energy production in a magnetic fusion device. Here we report the first observation of an edge transport barrier formation event in an electrostatic gyrokinetic simulation carried out in a realistic diverted tokamak edge geometry under strong forcing by a high rate of heat deposition. The results show that turbulent Reynolds-stress-driven sheared E×B flows act in concert with neoclassical orbit loss to quench turbulent transport and form a transport barrier just inside the last closed magnetic flux surface...
April 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28497543/critical-values-in-hematology-of-862-institutions-in-china
#8
Y Y Ye, H J Zhao, Y Fei, W Wang, F L He, K Zhong, S Yuan, Z G Wang
INTRODUCTION: A national survey on critical values in hematology of China laboratories was conducted to determine the current practice and assess the quality indicators so as to obtain a quality improvement. METHODS: Laboratories participating were asked to submit the general information, the practice of critical value reporting, and the status of timeliness of critical value reporting. RESULTS: A total of 862 laboratories submitted the results...
May 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28497130/not-all-that-glitters-is-gold-a-guide-to-critical-appraisal-of-animal-drug-trials-in-epilepsy
#9
Aristea S Galanopoulou, Wenzhu B Mowrey
Preclinical studies have produced numerous drugs with antiseizure properties which currently are the standard of care in clinical care. A third of the human population with epilepsy still continues having seizures despite the ongoing discoveries. The recognized clinical gaps of care that need to be addressed are the identification of antiepileptogenic and disease modifying treatments, treatments for refractory seizures or for seizures and epilepsies with limited or unsatisfactory treatments, such as early life epileptic encephalopathies...
December 2016: Epilepsia Open
https://www.readbyqxmd.com/read/28497114/selectable-markers-for-use-in-genetic-manipulation-of-extensively-drug-resistant-xdr-acinetobacter-baumannii-humc1
#10
Brian M Luna, Amber Ulhaq, Jun Yan, Paul Pantapalangkoor, Travis B Nielsen, Bryan W Davies, Luis A Actis, Brad Spellberg
Acinetobacter baumannii is one of the most antibiotic-resistant pathogens in clinical medicine, and extensively drug-resistant (XDR) strains are commonly isolated from infected patients. Such XDR strains are already resistant to traditional selectable genetic markers, limiting the ability to conduct pathogenesis research by genetic disruption. Optimization of selectable markers is therefore critical for the advancement of fundamental molecular biology techniques to use in these strains. We screened 23 drugs that constitute a broad array of antibiotics spanning multiple drug classes against HUMC1, a highly virulent and XDR A...
March 2017: MSphere
https://www.readbyqxmd.com/read/28496982/blood-gases-biochemistry-and-haematology-of-gal%C3%A3-pagos-hawksbill-turtles-eretmochelys-imbricata
#11
Juan Pablo Muñoz-Pérez, Gregory A Lewbart, Maximilian Hirschfeld, Daniela Alarcón-Ruales, Judith Denkinger, Jason Guillermo Castañeda, Juan García, Kenneth J Lohmann
The hawksbill turtle, Eretmochelys imbricata, is a marine chelonian with a circum-global distribution, but the species is critically endangered and has nearly vanished from the eastern Pacific. Although reference blood parameter intervals have been published for many chelonian species and populations, including nesting Atlantic hawksbills, no such baseline biochemical and blood gas values have been reported for wild Pacific hawksbill turtles. Blood samples were drawn from eight hawksbill turtles captured in near shore foraging locations within the Galápagos archipelago over a period of four sequential years; three of these turtles were recaptured and sampled on multiple occasions...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/28495349/factors-that-impact-patient-web-portal-readiness-pwpr-among-the-underserved
#12
Priya Nambisan
OBJECTIVE: Healthcare organizations in the US are increasingly using Patient Portals as a means to provide patients with partial access to their health records and thereby comply with the 'meaningful use' of Health Information Technology policy issued by the US federal government. Patient portals are used to not only provide access to parts of the health records such as lab results but also offer services such as customized educational materials and appointment scheduling. While prior studies examining the adoption rates of these patient portals have not offered consistent findings, many of the studies have reported limited adoption and use [1] of patient portals, especially among the underserved population...
June 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28491246/significance-of-coagulase-negative-staphylococcus-from-blood-cultures-persisting-problems-and-partial-progress-in-resource-constrained-settings
#13
Shailpreet K Sidhu, Sita Malhotra, Pushpa Devi, Arpandeep K Tuli
BACKGROUND AND OBJECTIVES: Coagulase negative Staphylococcus (CoNS) is frequently isolated from blood cultures but their significance is difficult to interpret. CoNS bacteria which are often previously dismissed as culture contaminants are attracting greater importance as true pathogens in the past decades. Clinical evaluation of these isolates suggests that although there is a relative increase of CoNS associated bloodstream infections in recent years, the microorganisms still remain the most common contaminants in blood cultures...
December 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28490181/annals-express-designing-and-evaluating-autoverification-rules-for-thyroid-function-profiles-and-sex-hormone-tests
#14
Jiancheng Li, Bizhen Cheng, Huizhen Ouyang, Tongtong Xiao, Jing Hu, Yingmu Cai
PURPOSE: Following the analytical phase, the current practice of many hospital laboratories involves the manual verification of all test results followed by the production of the report. However, manual verification is a time-consuming and tedious process. In this paper, we provide a detailed description of how to design autoverification rules for thyroid function test profiles and sex hormones. MaterialsandMethods: We used DM2 (Data manager 2) to construct the algorithm and build the database for autoverification of thyroid function test profiles and sex hormones, with reference to Boolean logic, Auto-10A and CLSI'88...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28481552/lio2-cryosynthesis-and-chemical-electrochemical-reactivities
#15
Xinmin Zhang, Limin Guo, Linfeng Gan, Yantao Zhang, Jing Wang, Lee R Johnson, Peter G Bruce, Zhangquan Peng
The reduction of O2 to solid Li2O2, via the intermediates O2(-) and LiO2, is the desired discharge reaction at the positive electrode of the aprotic Li-O2 batteries. In practice, a plethora of byproducts are identified together with Li2O2 and have been assigned to the side reactions between the reduced oxygen species (O2(-), LiO2, and Li2O2) and the battery components (the cathode and electrolyte). Understanding the reactivity of these reduced oxygen species is critical for the development of stable battery components and thus high cycle life...
May 11, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28471515/critical-points-for-an-accurate-human-genome-analysis
#16
REVIEW
Stefan J White, Jeroen F J Laros, Egbert Bakker, Anne Cambon-Thomsen, Martin Eden, Samantha Leonard, Hanns Lochmüller, Gert Matthijs, Christopher Mattocks, Simon Patton, Katherine Payne, Hans Scheffer, Erica Souche, Ellen Thomassen, Rachel Thompson, Jan Traeger-Synodinos, Steven Van Vooren, Bart Janssen, Johan T den Dunnen
Next-generation sequencing is radically changing how DNA diagnostic laboratories operate. What started as a single-gene profession is now developing into gene panel sequencing and whole exome and genome sequencing (WES/WGS) analyses. With further advances in sequencing technology and concomitant price reductions, whole genome sequencing (WGS) will soon become the standard and be routinely offered. Here we focus on the critical steps involved in performing WGS, with a particular emphasis on points where WGS differs from WES, the important variables that should be taken into account, and the quality control measures that can be taken to monitor the process...
May 4, 2017: Human Mutation
https://www.readbyqxmd.com/read/28467751/rabies-surveillance-in-the-united-states-during-2015
#17
Meseret G Birhane, Julie M Cleaton, Ben P Monroe, Ashutosh Wadhwa, Lillian A Orciari, Pamela Yager, Jesse Blanton, Andres Velasco-Villa, Brett W Petersen, Ryan M Wallace
OBJECTIVE To describe rabies and rabies-related events occurring during 2015 in the United States. DESIGN Observational study based on passive surveillance data. ANIMALS All animals submitted for rabies testing in the United States during 2015. PROCEDURES State and territorial public health programs provided data on animals submitted for rabies testing in 2015. Data were analyzed temporally and geographically to assess trends in domestic and sylvatic animal rabies cases. RESULTS During 2015, 50 states and Puerto Rico reported 5,508 rabid animals to the CDC, representing an 8...
May 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28462647/laboratory-risk-indicator-for-necrotising-fasciitis-lrinec-score-for-the-assessment-of-early-necrotising-fasciitis-a-systematic-review-of-the-literature
#18
J Bechar, S Sepehripour, J Hardwicke, G Filobbos
Introduction Early operative debridement of necrotising fasciitis is a major outcome determinant. Identification and diagnosis of such patients can be clinically difficult. The Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) score first published in 2004 is based on routinely performed parameters and offers a method for identifying early cases. No literature review has yet been performed on the application of such a score. Methods A systematic review of English-language literature was performed from 2004 to 2014 to identify articles reporting use of LRINEC score and the incidence of necrotising fasciitis...
May 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28462630/educational-cadaveric-module-for-teaching-percutaneous-and-intranasal-osteotomies-in-rhinoplasty
#19
Jenny X Chen, Elliott D Kozin, David A Shaye, Theresa Hadlock, Robin Lindsay, Linda N Lee
Lateral osteotomies are essential to rhinoplasty and are performed through percutaneous or intranasal approaches. Both techniques are difficult to teach as they rely on tactile feedback. Thus, it is critical to understand trainee learning curves to minimize complications. Herein, we aim to (1) demonstrate an educational module for teaching lateral osteotomies and (2) examine potential differences in outcomes between the 2 surgical approaches when performed by trainees. After a hands-on cadaveric laboratory, trainees (n = 24) reported increased confidence in performing both types of osteotomies ( P < ...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28456446/potential-mechanisms-behind-the-antioxidant-actions-of-prolactin-in-the-retina
#20
REVIEW
Stéphanie Thébault
Causes for age-related retinal diseases are numerous and complex, and they are intertwined with the natural vision decline that accompanies aging. The elucidation of endogenous mechanisms that help maintain retinal function under conditions that are threatening for the eye and happen during natural aging is therefore critical in developing new prevention and therapeutic strategies against age-related retinal degeneration. Our lab recently reported that the hormone of lactation, prolactin, helps the retinal pigment epithelium to survive via antioxidant actions that result in the inhibition of sirtuin2-dependent cell death (EbioMedicine issue of May)...
April 26, 2017: Experimental Eye Research
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