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https://www.readbyqxmd.com/read/29243301/evaluation-of-the-live-biotherapeutic-product-asymptomatic-bacteriuria-escherichia-coli-2-12-in-healthy-dogs-and-dogs-with-clinical-recurrent-uti
#1
G Segev, J E Sykes, D J Klumpp, A J Schaeffer, E M Antaki, B A Byrne, R E Yaggie, J L Westropp
BACKGROUND: Antimicrobial resistance is an emerging problem. HYPOTHESIS/OBJECTIVE: To investigate the safety and efficacy of a live biotherapeutic product, ASB E. coli 2-12 for UTI treatment. ANIMALS: Six healthy research dogs; nine client-owned dogs with recurrent UTI. METHODS: Prospective noncontrolled clinical trial. For safety data, research dogs were sedated, a urinary catheter was inserted into the bladder; 1010 CFU/mL of ASB E...
December 15, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29232047/antibiotic-prophylaxis-in-ureteroscopic-lithotripsy-a%C3%A2-systematic-review-and-meta-analysis-of-comparative-studies
#2
Tuo Deng, Bing Liu, Xiaolu Duan, Chao Cai, Zhijian Zhao, Wei Zhu, Junhong Fan, Wenqi Wu, Guohua Zeng
OBJECTIVE: To explore the efficacy and detailed strategies of antibiotic prophylaxis in ureteroscopic lithotripsy (URL) through a systematic review and meta-analysis. MATERIALS AND METHODS: A systematic literature search using Pubmed, Embase, Medline, Cochrane Library, CBM, CNKI and VIP databases was performed to obtain comparative studies on the efficacy of different antibiotic prophylaxis strategies in URL for preventing postoperative infections. The last search was conducted on June 25, 2017...
December 12, 2017: BJU International
https://www.readbyqxmd.com/read/29228072/an-implementation-guide-to-reducing-overtreatment-of-asymptomatic-bacteriuria
#3
Michael Daniel, Sara Keller, Mohammad Mozafarihashjin, Amit Pahwa, Christine Soong
Treatment of asymptomatic bacteriuria (ASB) frequently lacks appropriate indication, yet remains prevalent across settings. Numerous guidelines, professional societies, and campaigns such as Choosing Wisely advocate against this low-value practice. Efforts aimed at reducing unnecessary treatment of ASB demonstrate improved costs, and avoidable harm without increased risk of adverse events. We propose an evidence-based implementation guide to aid practitioners in reducing inappropriate treatment of ASB.
December 11, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29226170/inappropriate-management-of-asymptomatic-patients-with-positive-urine-cultures-a-systematic-review-and-meta-analysis
#4
Myrto Eleni Flokas, Nikolaos Andreatos, Michail Alevizakos, Alireza Kalbasi, Pelin Onur, Eleftherios Mylonakis
Background: Mismanagement of asymptomatic patients with positive urine cultures (referred to as asymptomatic bacteriuria [ASB] in the literature) promotes antimicrobial resistance and results in unnecessary antimicrobial-related adverse events and increased health care costs. Methods: We conducted a systematic review and meta-analysis of studies that reported on the rate of inappropriate ASB treatment published from 2004 to August 2016. The appropriateness of antimicrobial administration was based on guidelines published by the Infectious Diseases Society of America...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29224913/re-is-preoperative-assessment-and-treatment-of-asymptomatic-bacteriuria-necessary-for-reducing-the-risk-of-postoperative-symptomatic-urinary-tract-infection-after-urologic-surgical-procedures
#5
https://www.readbyqxmd.com/read/29224055/peri-operative-antibiotic-treatment-of-bacteriuria-reduces-early-deep-surgical-site-infections-in-geriatric-patients-with-proximal-femur-fracture
#6
Ronny Langenhan, Stefanie Bushuven, Niklas Reimers, Axel Probst
PURPOSE: The aim of this study was to conduct a re-evaluation of current strategies for peri-operative prophylaxis of infections in orthopaedic surgery of geriatric patients (≥65 years) with proximal femoral fractures (PFF). METHODS: Between 01/2010 and 08/2014 all post-operative infections after stabilization of PFF of 1,089 geriatric patients were recorded retrospectively. All patients pre-operatively received a single dose of 1.5 g cefuroxime (group 1). These were compared to prospectively determined post-operative rates of surgical site infection (SSI) of 441 geriatric patients, which were operated on between 09/2014 and 03/2017 due to PFF...
December 9, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29221467/urothelial-cells-may-indicate-underlying-bacteriuria-in-pregnancy-at-term-a-comparative-study
#7
N Liou, J Currie, C James, J Malone-Lee, A L David
BACKGROUND: Urinary tract infection is common in pregnancy. Urine is sampled from by mid-stream collection (MSU). If epithelial cells are detected, contamination by vulvo-vagial skin and skin bacteria is assumed. Outside pregnancy, catheter specimen urine (CSU) is considered less susceptible to contamination. We compared MSU and CSU methods in term pregnancy to test these assumptions. METHODS: Healthy pregnant women at term gestation (n = 32, median gestation 38 + 6 weeks, IQR 37 + 6-39 + 2) undergoing elective caesarean section provided a MSU and CSU for paired comparison that were each analysed for bacterial growth and bladder distress by fresh microscopy, sediment culture and immunofluorescent staining...
December 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29204224/bacteriology-and-antibiogram-of-urinary-tract-infection-among-female-patients-in-a-tertiary-health-facility-in-south-eastern-nigeria
#8
REVIEW
Angus N Oli, Vivian B Akabueze, Chijioke E Ezeudu, George U Eleje, Obiora S Ejiofor, Ifeanyichukwu U Ezebialu, Charlotte B Oguejiofor, Ifeoma M Ekejindu, George O Emechebe, Kenneth N Okeke
Background: Urinary Tract Infection (UTI) is a common contagion among men and women with the incidence relatively higher among women due to their differing anatomy. An understanding of the kind of pathogens implicated in urinary tract infections as well as antibiotic susceptibility profiling may help the clinician make rationally correct empirical choice in their treatment. Objective: This study is aimed at determining the type and antibiotic susceptibility pattern of bacterial uropathogens isolated from female patients attending Chukwuemeka Odumegwu Ojukwu University Teaching Hospital (COOUTH), Awka, Nigeria...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/29183930/reducing-catheter-associated-urinary-tract-infections-in-hospitals-study-protocol-for-a-multi-site-randomised-controlled-study
#9
Brett G Mitchell, Oyebola Fasugba, Anne Gardner, Jane Koerner, Peter Collignon, Allen C Cheng, Nicholas Graves, Peter Morey, Victoria Gregory
INTRODUCTION: Despite advances in infection prevention and control, catheter-associated urinary tract infections (CAUTIs) are common and remain problematic. A number of measures can be taken to reduce the risk of CAUTI in hospitals. Appropriate urinary catheter insertion procedures are one such method. Reducing bacterial colonisation around the meatal or urethral area has the potential to reduce CAUTI risk. However, evidence about the best antiseptic solutions for meatal cleaning is mixed, resulting in conflicting recommendations in guidelines internationally...
November 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29177489/disease-based-antimicrobial-stewardship-a-review-of-active-and-passive-approaches-to-patient-management
#10
Farnaz Foolad, Jerod L Nagel, Gregory Eschenauer, Twisha S Patel, Cynthia T Nguyen
Although new antimicrobial stewardship programmes (ASPs) often begin by targeting the reduction of antimicrobial use, an increasing focus of ASPs is to improve the management of specific infectious diseases. Disease-based antimicrobial stewardship emphasizes improving patient outcomes by optimizing antimicrobial use and increasing compliance with performance measures. Directing efforts towards the comprehensive management of specific infections allows ASPs to promote the shift in healthcare towards improving quality, safety and patient outcome metrics for specific diseases...
December 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29174023/antibiotic-treatment-of-asymptomatic-bacteriuria-prior-to-hip-and-knee-arthroplasty-a-systematic-review-of-the-literature
#11
REVIEW
Alistair I W Mayne, Peter S E Davies, James M Simpson
BACKGROUND: There is significant debate as to whether routine antibiotic treatment of asymptomatic bacteriuria (ASB) in arthroplasty patients reduces the risk of subsequent PJI. No previous systematic reviews have been undertaken on this subject. The aim of this systematic review was to investigate whether antibiotic treatment of asymptomatic bacteriuria in arthroplasty patients reduces the risk of prosthetic joint infection and to investigate whether the organisms cultured in peri-operative urine samples are the same as those responsible for subsequent prosthetic joint infections...
November 21, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29170899/preoperative-urine-culture-is-unnecessary-in-asymptomatic-men-prior-to-prostate-needle-biopsy
#12
David Z Qi, Kathleen Lehman, Kalyan Dewan, Girish Kirimanjeswara, Jay D Raman
PURPOSE: To determine the clinical utility of preoperative urine cultures in asymptomatic men undergoing prostate needle biopsy (PNB). METHODS: One hundred fifty asymptomatic men had urine cultures obtained 14-days prior to PNB. As per study protocol, positive cultures were not treated. Antibiotic prophylaxis prior to PNB included ciprofloxacin 500 mg the night before and morning of the biopsy. Repeat urine cultures were obtained immediately prior to PNB with colony-forming units (CFUs) annotated...
November 23, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29149963/urinary-tract-infections-in-the-first-year-post-kidney-transplantation-potential-benefits-of-treating-asymptomatic-bacteriuria
#13
P Kotagiri, D Chembolli, J Ryan, P D Hughes, N D Toussaint
BACKGROUND: Urinary tract infections (UTIs) are the commonest infectious complication in kidney transplant recipients (KTRs). No recommendations exist regarding treatment of asymptomatic bacteriuria. We aimed to identify potential risk factors and microbiological profile for UTIs, the role of treatment of asymptomatic bacteriuria, and effects on graft outcomes of bacteriuria within the first year post-transplantation. METHODS: We performed a retrospective analysis of UTIs in KTRs transplanted between January 2012 and December 2013 in 2 transplantation centers...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29129031/evaluation-and-management-of-staphylococcus-aureus-bacteriuria-an-updated-review
#14
REVIEW
Stamatis Karakonstantis, Dimitra Kalemaki
BACKGROUND AND AIMS: There is little guidance regarding the evaluation and management of patients with Staphylococcus aureus bacteriuria (SABU). Here, we aimed to provide an up-to-date review of the literature. METHODS: We searched PubMed, Scopus, and clinical trial registries for articles evaluating the epidemiology of SABU, risk factors of SABU, the association of SABU with urinary tract infection, bacteremia and invasive S. aureus infections, and the management of patients with SABU...
November 11, 2017: Infection
https://www.readbyqxmd.com/read/29117329/preterm-birth-associated-with-group-b-streptococcus-maternal-colonization-worldwide-systematic-review-and-meta-analyses
#15
Fiorella Bianchi-Jassir, Anna C Seale, Maya Kohli-Lynch, Joy E Lawn, Carol J Baker, Linda Bartlett, Clare Cutland, Michael G Gravett, Paul T Heath, Margaret Ip, Kirsty Le Doare, Shabir A Madhi, Samir K Saha, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Craig E Rubens
Background: Preterm birth complications are the leading cause of deaths among children <5 years of age. Studies have suggested that group B Streptococcus (GBS) maternal rectovaginal colonization during pregnancy may be a risk factor for preterm delivery. This article is the fifth of 11 in a series. We aimed to assess the association between GBS maternal colonization and preterm birth in order to inform estimates of the burden of GBS. Methods: We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data from investigator groups on the association of preterm birth (<37 weeks' gestation) and maternal GBS colonization (GBS isolation from vaginal, cervical, and/or rectal swabs; with separate subanalysis on GBS bacteriuria)...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29107038/routine-urine-testing-at-the-spinal-cord-injury-annual-evaluation-leads-to-unnecessary-antibiotic-use-a-pilot-study-and-future-directions
#16
Felicia Skelton, Larissa Grigoryan, Sally Ann Holmes, Ivy Oiyee Poon, Barbara Trautner
OBJECTIVE: To measure the prevalence of ASB in persons with spinal cord injury (SCI) at the time of their annual examination, and examine the impact on urine testing during the annual examination on subsequent antibiotic use. DESIGN: retrospective cohort study SETTING: a major Veterans Health Administration SCI center PARTICIPANTS: Veterans with SCI seen for an outpatient annual evaluation in 2012 or 2013 (n=393) MAIN OUTCOME MEASURE: antibiotic use for bacteriuria within seven days of the annual evaluation encounter RESULTS: Of the 327 clinic visits that met inclusion criteria, of which 249 had a urine culture performed...
October 26, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29102949/effect-of-preoperative-bacteriuria-and-pyuria-on-intravesical-recurrence-in-patients-with-upper-tract-urothelial-carcinoma-undergoing-radical-nephroureterectomy
#17
Hiroshi Fukushima, Masaki Kobayashi, Keizo Kawano, Shinji Morimoto
BACKGROUND/AIM: We investigated the effect of bacteriuria and pyuria on intravesical recurrence (IVR) in patients with upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU). PATIENTS AND METHODS: Preoperative bacteriuria and pyuria were defined as urine containing ≥5 bacteria/high-power field (HPF) and >5 white blood cells/HPF, respectively. Their associations with IVR were evaluated in 97 patients with UTUC undergoing RNU. RESULTS: Preoperative bacteriuria [n=15 (15%)] was significantly associated with preoperative pyuria [n=42 (43%), p<0...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29099028/post-stroke-bacteriuria-a-longitudinal-study-among-stroke-outpatients-and-inpatients-at-the-korle-bu-teaching-hospital-in-ghana
#18
Eric S Donkor, Samuel Darkwah, Albert Akpalu
Infections of the urinary tract constitute an important post-stroke complication but in Africa, little is known about such infections in relation to stroke patients. The aim of the study was to investigate the epidemiology of bacteriuria among stroke patients at the Korle-Bu Teaching Hospital (KBTH) in Ghana including the prevalence, incidence, risk factors and aetiological agents. This was a longitudinal study involving 55 outpatients and 16 inpatients of stroke from the physiotherapy clinic and stroke admission ward of KBTH respectively...
June 2, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29079155/urinary-tract-infection-and-asymptomatic-bacteriuria-in-older-adults
#19
REVIEW
Nicolas W Cortes-Penfield, Barbara W Trautner, Robin L P Jump
Urinary tract infections (UTIs) are a significant cause of morbidity among older adults. However, antibiotic prescriptions for clinically suspected UTIs are often inappropriate. Health care providers frequently struggle to differentiate UTI from asymptomatic bacteriuria, particularly in patients presenting with nonspecific symptoms. Patients with baseline cognitive impairments that limit history-taking can be particularly challenging. This article reviews the epidemiology and pathogenesis of UTI in older adults...
December 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29071162/evaluation-of-the-risk-factors-associated-with-the-development-of-post-transurethral-resection-of-the-prostate-persistent-bacteriuria
#20
Tarek Osman, Karim Omar ElSaeed, Hassan A Youssef, Mohamed Shabayek, Ahmed Emam, Mohammed Saad Hussein
OBJECTIVES: To determine the preoperative, intraoperative and postoperative risk factors that influence the development of persistent post-transurethral resection of the prostate (TURP) urinary tract infection (UTI) defined as pyuria and/or bacteriuria remaining for 3 weeks after surgery. PATIENTS AND METHODS: This is a prospective study including 100 patients scheduled for TURP. Urine analysis and culture was performed immediately after catheter removal, then at 1 and 3 weeks postoperatively, and the results were correlated to various preoperative, intraoperative and postoperative potential risk factors to detect any significant relation to persistent UTI...
September 2017: Arab Journal of Urology
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