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https://www.readbyqxmd.com/read/27283207/occupational-dermal-exposure-to-nanoparticles-and-nano-enabled-products-part-2-exploration-of-exposure-processes-and-methods-of-assessment
#1
Derk H Brouwer, Suzanne Spaan, Martin Roff, Anne Sleeuwenhoek, Ilse Tuinman, Henk Goede, Birgit van Duuren-Stuurman, Francesca Larese Filon, Dhimiter Bello, John W Cherrie
Over the past decade, the primary focus of nanotoxicology and nanoenvironmental health and safety efforts has been largely on inhalation exposure to engineered nanomaterials, at the production stage, and much less on considering risks along the life cycle of nano-enabled products. Dermal exposure to nanomaterials and its health impact has been studied to a much lesser extent, and mostly in the context of intentional exposure to nano-enabled products such as in nanomedicine, cosmetics and personal care products...
August 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/26452598/defects-tolerant-co-cr-mo-dental-alloys-prepared-by-selective-laser-melting
#2
B Qian, K Saeidi, L Kvetková, F Lofaj, C Xiao, Z Shen
OBJECTIVES: CrCoMo alloy specimens were successfully fabricated using selective laser melting (SLM). The aim of this study was to carefully investigate microstructure of the SLM specimens in order to understand the influence of their structural features inter-grown on different length scales ranging from nano- to macro-levels on their mechanical properties. METHODS: Two different sets of processing parameters developed for building the inner part (core) and the surface (skin) of dental prostheses were tested...
December 2015: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/25249382/application-of-the-skin-and-bone-integrated-pylon-with-titanium-oxide-nanotubes-and-seeded-with-dermal-fibroblasts
#3
Maxim A Shevtsov, Natalia Yudintceva, Miralda Blinova, George Pinaev, Oleg Galibin, Igor Potokin, Ketul C Popat, Mark Pitkin
BACKGROUND: Direct skeletal attachment of limb prostheses is associated with high rate of transcutaneous infection and loosening of the fixture in the medullary canal prompting for careful assessment of various means for enhancing the skin-device and bone-device interface. The skin and bone integrated pylon system constitutes a technological platform for different modifications being evaluated previously. OBJECTIVES: The current study assessed the combination of nano-treatment skin and bone integrated pylon with its pre-seeding with dermal fibroblasts...
December 2015: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/24766639/lipid-based-capsaicin-loaded-nano-colloidal-biocompatible-topical-carriers-with-enhanced-analgesic-potential-and-decreased-dermal-irritation
#4
Kaisar Raza, Mohammad Afroz Shareef, Parteek Singal, Gajanand Sharma, Poonam Negi, Om Prakash Katare
Capsaicin (CP), a recent FDA-approved drug for the topical treatment of neuropathic pain, is associated with several side effects like irritation, burning sensation, and erythema, resulting in poor patient compliance. The present study is an attempt to study the effect of CP encasement in nano-lipoidal carriers (NLCs) on skin-transport characteristics, in vivo pharmacological performance, skin compliance, and stability of the finished product. The study also compares two methods of NLC preparation, namely microemulsification and rotary-evaporation for various attributes...
December 2014: Journal of Liposome Research
https://www.readbyqxmd.com/read/24734511/dexamethasone-loaded-poly-d-l-lactic-acid-microspheres-poly-ethylene-glycol-poly-epsilon-caprolactone-poly-ethylene-glycol-micelles-composite-for-skin-augmentation
#5
Min Fan, Jinfeng Liao, Gang Guo, Qiuxia Ding, Yi Yang, Feng Luo, Zhiyong Qian
Soft tissue augmentation using various injectable fillers has gained popularity as more patients seek esthetic improvement through minimally invasive procedures requiring little or no recovery time. The currently available injectable skin fillers can be divided into three categories. With careful assessment, stimulatory fillers are the most ideal fillers. In this study, dexamethasone-loaded poly(D, L-lactic acid) (PLA) microspheres of approximately 90 micro m suspended in poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) micelles were prepared as stimulatory filler for skin augmentation...
April 2014: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/24389615/-nanomaterials-in-cosmetics-present-situation-and-future
#6
REVIEW
Takuji Masunaga
Cosmetics are consumer products intended to contribute to increasing quality of life and designed for long-term daily use. Due to such features of cosmetics, they are required to ensure quality and safety at a high level, as well as to perform well, in response to consumers' demands. Recently, the technology associated with nanomaterials has progressed rapidly and has been applied to various products, including cosmetics. For example, nano-sized titanium dioxide has been formulated in sunscreen products in pursuit of improving its performance...
2014: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/22988620/cosmetics-as-a-potential-source-of-environmental-contamination-in-the-uk
#7
Danelle Dhanirama, Jan Gronow, Nikolaos Voulvoulis
Chemicals of emerging concern (CECs) are frequently used in cosmetic formulations and can potentially reach the environment at concentrations that may cause harm. A methodology was developed to assess over 120 chemicals assembled from product ingredient listings to identify and validate potential CECs in cosmetics, based on Annex XIII of REACH legislation. Ten potential CECs were identified: polydimethylsiloxane, butylated hydroxylanisole (BHA), butylated hydroxytoluene, triclosan, nano titanium dioxide, nano zinc oxide, butylparaben, diethyl phthalate, octinoxate methoxycinnamate and benzophenone...
July 2012: Environmental Technology
https://www.readbyqxmd.com/read/22466067/nano-sized-cosmetic-formulations-or-solid-nanoparticles-in-sunscreens-a-risk-to-human-health
#8
REVIEW
Gerhard J Nohynek, Eric K Dufour
Personal care products (PCP) often contain micron- or nano-sized formulation components, such as nanoemulsions or microscopic vesicles. A large number of studies suggest that such vesicles do not penetrate human skin beyond the superficial layers of the stratum corneum. Nano-sized PCP formulations may enhance or reduce skin absorption of ingredients, albeit at a limited scale. Modern sunscreens contain insoluble titanium dioxide (TiO₂) or zinc oxide (ZnO) nanoparticles (NP), which are efficient filters of UV light...
July 2012: Archives of Toxicology
https://www.readbyqxmd.com/read/21842867/gold-nano-popcorn-attached-swcnt-hybrid-nanomaterial-for-targeted-diagnosis-and-photothermal-therapy-of-human-breast-cancer-cells
#9
Lule Beqa, Zhen Fan, Anant Kumar Singh, Dulal Senapati, Paresh Chandra Ray
Breast cancer presents greatest challenge in health care in today's world. The key to ultimately successful treatment of breast cancer disease is an early and accurate diagnosis. Current breast cancer treatments are often associated with severe side effects. Driven by the need, we report the design of novel hybrid nanomaterial using gold nano popcorn-attached single wall carbon nanotube for targeted diagnosis and selective photothermal treatment. Targeted SK-BR-3 human breast cancer cell sensing have been performed in 10 cancer cells/mL level, using surface enhanced Raman scattering of single walls carbon nanotube's D and G bands...
September 2011: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/21786335/chronic-exposure-to-nanosized-anatase-titanium-dioxide-is-not-cyto-or-genotoxic-to-chinese-hamster-ovary-cells
#10
Shuguang Wang, Lindsey A Hunter, Zikri Arslan, Michael G Wilkerson, Jeffrey K Wickliffe
Titanium dioxide nanoparticles (nano-TiO(2) ) are widely used in cosmetics, skin care products, paints, and water treatment processes. Disagreement remains regarding the safety of nano-TiO(2) , and little epidemiological data is available to provide needed resolution. Most studies have examined effects using acute exposure experiments with relatively few studies using a chronic exposure design. We examined cyto- and genotoxicity in CHO-K1 cells following 60 days of continuous exposure to defined levels of nano-TiO(2) (0, 10, 20, or 40 μg/ml)...
October 2011: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/21342155/nanoparticles-small-and-mighty
#11
REVIEW
Alison Wiesenthal, Lindsey Hunter, Shuguang Wang, Jeffrey Wickliffe, Michael Wilkerson
The properties of engineered nanomaterials and nanoparticles such as zinc oxide and titanium dioxide may differ substantially from naturally occurring materials and particles. Nanoparticles have unique physical properties making them ideal for use in various skin care products currently on the market. Nano-preparations are currently under investigation as novel treatments of acne vulgaris, recurrent condyloma accuminata, atopic dermatitis, hyperpigmented skin lesions, and other non-dermatologic diseases. Because of their increased surface area, nanoparticles have increased reactivity and a small size allowing for enhanced mobility through the human body and environment...
March 2011: International Journal of Dermatology
https://www.readbyqxmd.com/read/20705894/small-amounts-of-zinc-from-zinc-oxide-particles-in-sunscreens-applied-outdoors-are-absorbed-through-human-skin
#12
Brian Gulson, Maxine McCall, Michael Korsch, Laura Gomez, Philip Casey, Yalchin Oytam, Alan Taylor, Malcolm McCulloch, Julie Trotter, Leslie Kinsley, Gavin Greenoak
Metal oxide nanoparticles are commonly used in personal-care formulations as protective agents against exposure to ultraviolet radiation. Although previous research has concluded that nanoparticles do not penetrate healthy skin, it remains contentious whether this conclusion holds under normal conditions of sunscreen use. Humans (n = 20) were exposed to sunscreens containing zinc oxide (ZnO) particles to determine if Zn from the particles was absorbed through skin over five consecutive days under outdoor conditions...
November 2010: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/20498896/molecular-self-assembly-and-applications-of-designer-peptide-amphiphiles
#13
REVIEW
Xiubo Zhao, Fang Pan, Hai Xu, Mohammed Yaseen, Honghong Shan, Charlotte A E Hauser, Shuguang Zhang, Jian R Lu
Short synthetic peptide amphiphiles have recently been explored as effective nanobiomaterials in applications ranging from controlled gene and drug release, skin care, nanofabrication, biomineralization, membrane protein stabilization to 3D cell culture and tissue engineering. This range of applications is heavily linked to their unique nanostructures, remarkable simplicity and biocompatibility. Some peptide amphiphiles also possess antimicrobial activities whilst remaining benign to mammalian cells. These attractive features are inherently related to their selective affinity to different membrane interfaces, high capacity for interfacial adsorption, nanostructuring and spontaneous formation of nano-assemblies...
September 2010: Chemical Society Reviews
https://www.readbyqxmd.com/read/20480790/nanoparticles-a-closer-look-at-their-dermal-effects
#14
REVIEW
Adrienne N Choksi, Tasneem Poonawalla, Michael G Wilkerson
Nano-sized particles represent a unique class of materials with novel physiochemical properties due to increased surface area. Many sunscreens and cosmetics are now using nano-sized titanium dioxide and zinc oxide, which avoids the white, chalky appearance of the older preparations. Although the U.S. Food and Drug Administration (FDA) has determined that nano-sized titanium dioxide is not a new ingredient, but a specific grade of the original product, recent studies suggest that nanomaterials products may not be equivalent to their respective bulk-form products, and the adverse effects of nanoparticles cannot be reliably predicted from the properties of the material in bulk form...
May 2010: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/20055090/silver-nanolipid-complex-for-application-to-atopic-dermatitis-skin-rheological-characterization-in-vivo-efficiency-and-theory-of-action
#15
Cornelia M Keck, Kay Schwabe
A skin care formulation was developed by incorporating microsilver, in combination with nanostructured lipid carriers (NLC) into an o/w cream and lotion. To increase skin adhesion of the NLC, and subsequent film formation and occlusion onto the skin, the NLC were produced with a size of about 200 nm. Production of NLC was performed by high-pressure homogenisation. Characterization was performed regarding size and charge (zeta potential), and for the cream and lotion also by rheology. Incorporation of NLC and/or microsilver into the cream or lotion led to pronounced changes in the thixotropic behaviour (shape of rheogram, yield point, viscosity)...
August 2009: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/19374041/the-new-start-dressing-range-urgotul-start-urgocell-start
#16
REVIEW
Gail Powell
Delayed wound healing has implications both for the clinician and the patient, as well as having a financial burden on the National Health Service. UrgoCell Start and Urgotul Start are the first dressings on the drug tariff to be impregnated with Nano-OligoSaccharide Factor (NOSF), a new compound that aims to promote wound closure through the inhibition of matrix metalloproteinase (MMP) activity. The dressings are designed to 'kick-start' wounds that are at risk of delayed healing. there is good clinical evidence, comprising multi-centre Randomized Controlled Trials, an observational study and case studies, to support the process of MMP inhibition and its clinical efficacy in kick-starting wound healing...
March 26, 2009: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/19123677/imaging-of-zinc-oxide-nanoparticle-penetration-in-human-skin-in-vitro-and-in-vivo
#17
Andrei V Zvyagin, Xin Zhao, Audrey Gierden, Washington Sanchez, Justin A Ross, Michael S Roberts
Zinc oxide (ZnO-nano) and titanium dioxide nanoparticles (20 to 30 nm) are widely used in several topical skin care products, such as sunscreens. However, relatively few studies have addressed the subdermal absorption of these nanoparticles in vivo. We report on investigation of the distribution of topically applied ZnO in excised and in vivo human skin, using multiphoton microscopy (MPM) imaging with a combination of scanning electron microscopy (SEM) and an energy-dispersive x-ray (EDX) technique to determine the level of penetration of nanoparticles into the sub-dermal layers of the skin...
November 2008: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/18689924/electrospun-nanofiber-scaffolds-engineering-soft-tissues
#18
REVIEW
S G Kumbar, R James, S P Nukavarapu, C T Laurencin
Electrospinning has emerged to be a simple, elegant and scalable technique to fabricate polymeric nanofibers. Pure polymers as well as blends and composites of both natural and synthetics have been successfully electrospun into nanofiber matrices. Physiochemical properties of nanofiber matrices can be controlled by manipulating electrospinning parameters to meet the requirements of a specific application. Such efforts include the fabrication of fiber matrices containing nanofibers, microfibers, combination of nano-microfibers and also different fiber orientation/alignments...
September 2008: Biomedical Materials
https://www.readbyqxmd.com/read/18596533/absorbable-intradermal-closure-of-elective-craniotomy-wounds
#19
Sergio Paolini, Roberta Morace, Giuseppe Lanzino, Paolo Missori, Giovanni Nano, Giampaolo Cantore, Vincenzo Esposito
OBJECTIVE: More and more commonly, craniotomies are being performed with minimal hair shaving to improve cosmesis and facilitate return to a normal life. In such patients, traditional sutures or metal staples are used for scalp closure. This practice requires suture removal, often perceived as a cause of discomfort by the patient. We investigate the safety and efficacy of intradermal sutures in a large, consecutive series of patients undergoing elective craniotomy. METHODS: Wound healing complications were investigated in a consecutive series of 208 patients who underwent elective craniotomy during a 2-year period...
May 2008: Neurosurgery
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