keyword
MENU ▼
Read by QxMD icon Read
search

Colistin resistant

keyword
https://www.readbyqxmd.com/read/28716360/comparison-of-synergism-between-colistin-fosfomycin-and-tigecycline-against-extended-spectrum-%C3%AE-lactamase-producing-klebsiella-pneumoniae-isolates-or-with-carbapenem-resistance
#1
Yee-Huang Ku, Chi-Chung Chen, Mei-Feng Lee, Yin-Ching Chuang, Hung-Jen Tang, Wen-Liang Yu
PURPOSE: To investigate the synergistic and bactericidal effects of antimicrobial combinations of any two of colistin, fosfomycin and tigecycline against the nine extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae (KP) clinical isolates, including 4 carbapenem-susceptible strains and five imipenem and/or meropenem-resistant strains. METHODS: In vitro synergism and bactericidal activity of combination of colistin, fosfomycin and tigecycline were evaluated by time-kill studies in standard inoculum of bacterial densities of a suspension containing 5 × 10(5) CFU/mL by using 1/2× MIC for each alone, and both 1/2× and 1/4× MIC for any two drugs...
July 6, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28716109/clinical-characteristics-and-outcomes-of-pseudomonas-aeruginosa-bacteremia-in-febrile-neutropenic-children-and-adolescents-with-the-impact-of-antibiotic-resistance-a-retrospective-study
#2
Hyo Sup Kim, Bo Kyoung Park, Seong Koo Kim, Seung Beom Han, Jae Wook Lee, Dong-Gun Lee, Nack-Gyun Chung, Bin Cho, Dae Chul Jeong, Jin Han Kang
BACKGROUND: Although the proportion of Pseudomonas aeruginosa infections has reduced after the introduction of antibiotics with anti-pseudomonal effects, P. aeruginosa bacteremia still causes high mortality in immunocompromised patients. This study determined the clinical characteristics and outcomes of P. aeruginosa bacteremia and the antibiotic susceptibilities of strains isolated from febrile neutropenic patients. METHODS: Thirty-one febrile neutropenic children and adolescents with underlying hematologic/oncologic disorders diagnosed with P...
July 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28711559/outbreak-of-colistin-resistant-carbapenemase-producing-klebsiella-pneumoniae-in-tunisia
#3
Wejdène Mansour, Marisa Haenni, Estelle Saras, Raoudha Grami, Yosra Mani, Anis Ben Haj Khalifa, Souhail El Atrouss, Mohamed Kheder, Mohamed Fekih Hassen, Noureddine Boujâafar, Olfa Bouallegue, Jean-Yves Madec
OBJECTIVES: Mechanisms of colistin and carbapenem resistance among a collection of Klebsiella pneumoniae isolates recovered in a university hospital in Tunisia were studied. METHODS: In vitro antimicrobial susceptibility testing, S1 nuclease pulsed-field gel electrophoresis (S1-PFGE), Southern blotting and PCR-based replicon typing (PBRT) were performed. Extended-spectrum β-lactamases (ESBLs), carbapenemases, AmpC-type enzymes and mgrB genes were detected by PCR and sequencing...
July 12, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28711441/emergence-of-carbapenem-resistant-acinetobacter-baumannii-st787-in-clinical-isolates-from-blood-in-a-tertiary-teaching-hospital-in-northern-taiwan
#4
Yi-Fan Hu, Charles Jia-Yin Hou, Chien-Feng Kuo, Nai-Yu Wang, Alice Ying-Jung Wu, Ching-Hsiang Leung, Chang-Pan Liu, Hung-I Yeh
BACKGROUND/PURPOSE: The purpose of this study is to investigate the predominant clones of carbapenem-resistant Acinetobacter baumannii (CRAB) in our hospital in Taiwan by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) technique. METHODS: We collected 108 non-duplicate A. baumannii clinical blood isolates from January 2012 to December 2013 in MacKay Memorial Hospital. PFGE and MLST were used for typing the A. baumannii isolates and for investigation of the predominant clones...
June 22, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28706882/distribution-of-the-strains-of-multidrug-resistant-extensively-drug-resistant-and-pandrug-resistant-pseudomonas-aeruginosa-isolates-from-burn-patients
#5
Hajieh Ghasemian Safaei, Sharareh Moghim, Bahram Nasr Isfahani, Hossein Fazeli, Farkhondeh Poursina, Sima Yadegari, Pourya Nasirmoghadas, Seyed Abolfazl Hosseininassab Nodoushan
BACKGROUND: Pseudomonas aeruginosa is an opportunistic and Gram-negative pathogen that is used as the most important factor in burn wound infections, and due to the rapid acquisition of multidrug resistance (MDR), it causes high mortality rates in these sectors. Thus, diagnosis and assessment of antibiotic resistance patterns are very important in these patients. The aim of this study was to evaluate antibiotic resistance pattern and determining P. aeruginosa MDR. MATERIALS AND METHODS: In this study, phenotypic, biochemical, and polymerase chain reaction tests were used to identify P...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28705960/draft-whole-genome-assemblies-of-drug-resistant-clinical-isolates-of-klebsiella-pneumoniae-from-the-philippines
#6
Marylette B Roa, Veni R Liles, Brian Carlmichael Torres, David Charles Klinzing, Evelina Lagamayo, Josephine Navoa-Ng, Maria Luisa G Daroy
Here, we report the draft assemblies of 11 clinical isolates of Klebsiella pneumoniae that are resistant to cephalosporins, carbapenems, and/or colistin. The assemblies ranged from 5.37 Mbp to 5.70 Mbp in size. Several plasmid sequences were present, and resistance genes spanning multiple classes of antibiotics were predicted.
July 13, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28705756/emergence-of-colistin-resistant-escherichia-coli-clinical-isolates-harboring-mcr-1-in-vietnam
#7
Tatsuya Tada, Pham Hong Nhung, Kayo Shimada, Mitsuhiro Tsuchiya, Doan Mai Phuong, Nguyen Quoc Anh, Norio Ohmagari, Teruo Kirikae
The mcr-1 was first detected on a plasmid in colistin-resistant Escherichia coli from livestock and patients in China. We described here the emergence of colistin-resistant E. coli clinical isolates harboring mcr-1 on the chromosomes in Vietnam. To our knowledge, this is the first report of hospital-acquired E. coli isolates harboring mcr-1 in a medical setting in Vietnam.
July 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28705668/in-vitro-activity-of-the-novel-fluorocycline-eravacycline-against-carbapenem-non-susceptible-acinetobacter-baumannii
#8
Harald Seifert, Danuta Stefanik, Joyce A Sutcliffe, Paul G Higgins
The activity of eravacycline was compared with anti-Acinetobacter reference antimicrobials against carbapenem non-susceptible Acinetobacter baumannii isolates associated with an acquired OXA or up-regulation of the intrinsic OXA-51-like enzyme. Antimicrobial susceptibility testing was performed by broth microdilution of 286 non-duplicate, carbapenem non-susceptible A. baumannii isolates to eravacycline, amikacin colistin, doxycycline, imipenem, levofloxacin, meropenem, minocycline, sulbactam, tigecycline, and tobramycin...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28700048/distribution-of-the-bla-oxa-bla-veb-1-and-bla-ges-1-genes-and-resistance-patterns-of-esbl-producing-pseudomonas-aeruginosa-isolated-from-hospitals-in-tehran-and-qazvin-iran
#9
Sahar Amirkamali, Taghi Naserpour-Farivar, Khadijeh Azarhoosh, Amir Peymani
INTRODUCTION: Pseudomonas aeruginosa is one of the most common nosocomial pathogens. The emergence of extended spectrum β-lactamases (ESBLs) has been increasingly reported as a major clinical concern worldwide. The main aim of the present study was to determine the distribution of bla OXA, bla PER-1, bla VEB-1, and bla GES-1 genes among ESBL-producing P. aeruginosa isolated from two distinct provinces in Iran. METHODS: In this study, a total of 75 (27.5%) ESBL-producing isolates were identified from 273 P...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28698568/an-allelic-variant-of-the-pmrb-sensor-kinase-responsible-for-colistin-resistance-in-an-escherichia-coli-strain-of-clinical-origin
#10
Antonio Cannatelli, Tommaso Giani, Noemi Aiezza, Vincenzo Di Pilato, Luigi Principe, Francesco Luzzaro, Cesira L Galeotti, Gian Maria Rossolini
We investigated the colistin resistance mechanism in an Escherichia coli strain (LC711/14) isolated in Italy in 2014, from an urinary tract infection, which was previously shown to express a colistin resistance mechanism different from mcr-1. LC711/14 was found to carry a novel mutation in the pmrB gene, resulting in a leucine to proline amino acid substitution at position 10 of the PmrB sensor kinase component of the PmrAB signal transduction system. The role of this substitution in colistin resistance was documented by expression of the wild-type and mutated alleles in a pmrB deletion derivative of the E...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28696672/magnetic-extraction-of-acinetobacter-baumannii-using-colistin-functionalized-%C3%AE-fe2o3-au-core-shell-composite-nanoclusters
#11
Charleson S Bell, Raquel Mejias, Sinead Miller, Jasmine Greer, Mark McClain, Timothy L Cover, Todd D Giorgio
Acinetobacter baumannii is a gram-negative bacterium of increasing concern due to its virulence and persistence in combat and healthcare environments. The incidence of both community-acquired and nosocomial A. baumannii infections is on the rise in foreign and domestic healthcare facilities. Treatment options are limited due to the acquisition of multi-drug resistance to the few effective antibiotics. Currently, the most effective pharmaceutically-based treatment for multi-drug-resistant A. baumannii infections is the antibiotic colistin (polymyxin E)...
July 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28694232/reinforcement-of-an-antimicrobial-stewardship-task-force-aims-at-a-better-use-of-antibiotics-of-last-resort-the-colitifos-study
#12
Benjamin Davido, Frédérique Bouchand, Aurélien Dinh, Christian Perronne, Maryvonne Villart, Olivia Senard, Jérome Salomon
BACKGROUND: Physicians are facing a worldwide increase in multidrug-resistant (MDR) organisms. Eradication of such bacteria, including so called superbugs (XDR), may cause physicians to prescribe last-resort antibiotics. However, experience with these drugs is limited and few data are available. METHODS: A before and after retrospective study was conducted from January 2008 to June 2016. Prescriptions of parenteral antimicrobials considered as last-resort antibiotics (colistin, fosfomycin, tigecycline and temocillin) were reviewed by 4 infectious disease specialists (according to microbiology results, susceptibility testing, clinical situation and alternative agents), while doses were analyzed by a pharmacist...
July 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28693691/prevalence-of-carbapenem-resistant-klebsiella-pneumoniae-crkp-and-the-distribution-of-class-1-integron-in-their-strains-isolated-from-a-hospital-in-central-china
#13
Ou Qin, Li Wenfang, Li Bei, Yu Chunfang
Objective The aim of our study is to investigate the prevalence of Carbapenem-resistant Klebsiella pneumoniae (CRKP) and the genetic characteristics of the class 1 integron in CRKP on multi-drug resistance.Methods Clinical Klebsiella pneumoniae strains were collected from multiple departments of a hospital in central China. CRKP strains were identified among the isolates, and antibiotics susceptibility of CRKP strains was analyzed. The polymerase chain reaction (PCR) was adopted to amplify the class 1 integron variable area...
June 10, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28692817/complications-of-hematopoietic-stem-transplantation-bacterial-infections
#14
REVIEW
Ali S Omrani, Reem S Almaghrabi
Bacterial infections remain a common complication of hematopoietic stem cell transplantation (HSCT), especially in the pre-engraftment phase. The risk of bacterial infections is mainly related to neutropenia, mucositis, and the presence of vascular lines. Most parts of the world have witnessed a shift in epidemiology toward Gram-negative bacteria; a large proportion of which are resistant to fluoroquinolones, extended-spectrum beta-lactams, carbapenems, and in some units even colistin. Meticulous infection control practices are essential for prevention of bacterial infections in HSCT...
July 3, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28689922/detection-of-the-colistin-resistance-gene-mcr-1-in-pathogenic-escherichia-coli-from-pigs-affected-by-post-weaning-diarrhoea-in-italy
#15
Ludovica Curcio, Andrea Luppi, Paolo Bonilauri, Yuri Gherpelli, Giovanni Pezzotti, Michele Pesciaroli, Chiara Francesca Magistrali
OBJECTIVES: The aim of this study was to investigate the presence of plasmid-mediated colistin resistance genes in Escherichia coli from pigs affected by post-weaning diarrhoea (PWD). METHODS: DNA samples collected from 51 E. coli isolates from Italian pigs affected by PWD in 2015-2016 were studied. Isolates were classified as presumptively resistant to colistin by routine susceptibility testing and were investigated for the presence of the mcr-1 gene of plasmid origin by PCR...
July 6, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28683827/expanding-landscapes-of-the-diversified-mcr-1-bearing-plasmid-reservoirs
#16
Qingjing Wang, Jian Sun, Jun Li, Youfa Ding, Xing-Ping Li, Jingxia Lin, Bachar Hassan, Youjun Feng
BACKGROUND: Polymyxin is a cationic polypeptide antibiotic that can disrupt bacterial cell membrane by interacting with its lipopolysaccharide molecules and is used as a last resort drug against lethal infections by the carbapenem-resistant superbugs (like NDM-1). However, global discovery of the MCR-1 colistin resistance dramatically challenges the newly renewed interest in colistin for clinical use. METHODS: The mcr-1-harboring plasmids were acquired from swine and human Escherichia coli isolated in China, from 2015 to 2016, and subjected to Illumina PacBio RSII and Hi-Seq2000 for full genome sequencing...
July 6, 2017: Microbiome
https://www.readbyqxmd.com/read/28680633/therapeutic-drug-monitoring-for-colistin-therapy-in-severe-multi-resistant-acinetobacter-intracerebral-abscess-a-single-case-study-with-high-dose-colistin-and-review-of-literature
#17
Sascha Tafelski, Lukas Wagner, Stefan Angermair, Maria Deja
OBJECTIVES: Intracranial infections due to multidrug- resistant (MDR) gram-negative pathogens are associated with increased morbidity and mortality. As therapeutic options are limited and systemic drug penetration into the infection focus is difficult, intraventricular therapy has been described. METHODS: We report on a patient with intracranial abscess caused by MDR Acinetobacter baumannii. RESULTS: He was treated with high doses of intravenous and intraventricular colistin resulting in microbiological clearance and clinical cure...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28679413/double-carbapenem-as-a-rescue-strategy-for-the-treatment-of-severe-carbapenemase-producing-klebsiella-pneumoniae-infections-a-two-center-matched-case-control-study
#18
Gennaro De Pascale, Gennaro Martucci, Luca Montini, Giovanna Panarello, Salvatore Lucio Cutuli, Daniele Di Carlo, Valentina Di Gravio, Roberta Di Stefano, Guido Capitanio, Maria Sole Vallecoccia, Piera Polidori, Teresa Spanu, Antonio Arcadipane, Massimo Antonelli
BACKGROUND: Recent reports have suggested the efficacy of a double carbapenem (DC) combination, including ertapenem, for the treatment of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) infections. We aimed to evaluate the clinical impact of such a regimen in critically ill patients. METHODS: This case-control (1:2), observational, two-center study involved critically ill adults with a microbiologically documented CR-Kp invasive infection treated with the DC regimen matched with those receiving a standard treatment (ST) (i...
July 5, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28676346/bloodstream-infections-caused-by-acinetobacter-species-with-reduced-susceptibility-to-tigecycline-clinical-features-and-risk-factors
#19
Ga Eun Park, Cheol-In Kang, Min Kyeong Cha, Sun Young Cho, Hyeri Seok, Ji Hye Lee, Ji Yeon Kim, Young Eun Ha, Doo Ryeon Chung, Kyong Ran Peck, Nam Yong Lee, Jae-Hoon Song
INTRODUCTION: During recent decades, the rates of multidrug resistance, including resistance to carbapenems, have increased dramatically among Acinetobacter species. Tigecycline has activity against multidrug-resistant Acinetobacter spp, including carbapenem-resistant isolates. However, reports of tigecycline-resistant Acinetobacter spp are emerging from different parts of the world. The purpose of this study was to evaluate potential risk factors associated with tigecycline non-susceptible Acinetobacter bacteremia...
July 1, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28676118/dissemination-of-carbapenem-resistant-klebsiella-pneumoniae-clinical-isolates-with-various-combinations-of-carbapenemases-kpc-2-ndm-1-ndm-4-and-oxa-48-and-16s-rrna-methylases-rmtb-and-rmtc-in-vietnam
#20
Tatsuya Tada, Mitsuhiro Tsuchiya, Kayo Shimada, Tran Thi Thanh Nga, Le Thi Anh Thu, Truong Thien Phu, Norio Ohmagari, Teruo Kirikae
METHODS: Twenty-seven clinical isolates of carbapenem-resistant Klebsiella pneumoniae with MICs ≥4 mg/L for imipenem or meropenem were obtained from inpatients in a hospital in Vietnam. Antimicrobial susceptibility tests and whole genome sequencing were performed. Multilocus sequence typing and the presence of drug resistant genes were determined and a maximum-likelihood phylogenetic tree was constructed by SNP alignment of whole genome sequencing data. RESULTS: All the isolates harbored one of genes encoding carbapenemases, including KPC-2, NDM-1, NDM-4 and OXA-48...
July 4, 2017: BMC Infectious Diseases
keyword
keyword
93867
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"