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Colistin resistant

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https://www.readbyqxmd.com/read/27895009/an-incp-plasmid-carrying-the-colistin-resistance-gene-mcr-1-in-klebsiella-pneumoniae-from-hospital-sewage
#1
Feifei Zhao, Yu Feng, Xiaoju Lü, Alan McNally, Zhiyong Zong
A Klebsiella pneumoniae strain of ST313 recovered from hospital sewage was found to carry the plasmid-borne colistin resistance gene mcr-1, which was bracketed by two copies of the insertion sequence ISApl1 on a 57-kb self-transmissible IncP type plasmid of a new IncP-1 clade. The carriage of mcr-1 on a self-transmissible broad-host-range plasmid highlights that mcr-1 has the potential to be spread beyond the Enterobacteriaceae.
November 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27894831/improvement-in-routine-detection-of-colistin-resistance-in-e-coli-isolated-in-veterinary-diagnostic-laboratories
#2
Eric Jouy, Marisa Haenni, Laëtitia Le Devendec, Aurélie Le Roux, Pierre Châtre, Jean-Yves Madec, Isabelle Kempf
We have developed a phenotypic method suited to the systematic screening of resistance to colistin in E. coli, including those with the mcr-1 gene, by the absence of an inhibition zone after an application of a single drop of 8mg/L colistin solution on a previously inoculated Mueller-Hinton agar.
November 25, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27894674/emergence-of-plasmid-mediated-colistin-resistance-and-new-delhi-metallo-%C3%AE-lactamase-genes-in-extensively-drug-resistant-escherichia-coli-isolated-from-a-patient-in-thailand
#3
Wantana Paveenkittiporn, Anusak Kerdsin, Sukanya Chokngam, Charatdao Bunthi, Somchai Sangkitporn, Christopher J Gregory
We reported a case of Escherichia coli with colistin resistance and an extensively drug-resistant phenotype. Molecular analysis revealed that the isolate carried mcr-1 and multiple β-lactamase genes includingblaNDM1, blaCTX-M-15, blaTEM1, and blaCMY-2. This is the first report of a clinical mcr-1 isolate in Thailand highlighting the urgent need for a comprehensive antimicrobial resistance containment strategy to prevent further spread.
November 14, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27893854/dissemination-and-mechanism-for-the-mcr-1-colistin-resistance
#4
Rongsui Gao, Yongfei Hu, Zhencui Li, Jian Sun, Qingjing Wang, Jingxia Lin, Huiyan Ye, Fei Liu, Swaminath Srinivas, Defeng Li, Baoli Zhu, Ya-Hong Liu, Guo-Bao Tian, Youjun Feng
Polymyxins are the last line of defense against lethal infections caused by multidrug resistant Gram-negative pathogens. Very recently, the use of polymyxins has been greatly challenged by the emergence of the plasmid-borne mobile colistin resistance gene (mcr-1). However, the mechanistic aspects of the MCR-1 colistin resistance are still poorly understood. Here we report the comparative genomics of two new mcr-1-harbouring plasmids isolated from the human gut microbiota, highlighting the diversity in plasmid transfer of the mcr-1 gene...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27891118/colistin-in-pig-production-chemistry-mechanism-of-antibacterial-action-microbial-resistance-emergence-and-one-health-perspectives
#5
REVIEW
Mohamed Rhouma, Francis Beaudry, William Thériault, Ann Letellier
Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in both human and veterinary medicine. For several years now, colistin has been considered the last line of defense against infections caused by multidrug-resistant Gram-negative such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Colistin has been extensively used orally since the 1960s in food animals and particularly in swine for the control of Enterobacteriaceae infections. However, with the recent discovery of plasmid-mediated colistin resistance encoded by the mcr-1 gene and the higher prevalence of samples harboring this gene in animal isolates compared to other origins, livestock has been singled out as the principal reservoir for colistin resistance amplification and spread...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27881539/coexistence-of-fosfomycin-and-colistin-resistance-in-klebsiella-pneumoniae-whole-genome-shotgun-sequencing
#6
Balaji Veeraraghavan, Susmitha K Perumalla, Naveen Kumar Devanga Ragupathi, Agila Kumari Pragasam, Dhiviya Prabaa Muthuirulandi Sethuvel, Sandhana Inian, Francis Yesurajan Inbanathan
Resistance to colistin is a major threat that limits therapeutic choices for treating carbapenem-resistant Klebsiella pneumoniae infections. Herein, we report the draft genome sequences of two colistin-resistant K. pneumoniae isolates (BA41763 and B6753). The sequence data indicate that BA41763 and B6753 contain genomes of ~5.9 and 5.7 Mb in size with several plasmids.
November 23, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27880936/dietary-grape-seed-proanthocyanidins-gsps-improve-weaned-intestinal-microbiota-and-mucosal-barrier-using-a-piglet-model
#7
Meng Han, Peixia Song, Chang Huang, Arash Rezaei, Shabnam Farrar, Michael A Brown, Xi Ma
Proanthocyanidins have been suggested as an effective antibiotic alternative, however their mechanisms are still unknown. The present study investigated the effects of grape seed proanthocyanidins on gut microbiota and mucosal barrier using a weaned piglet model in comparison with colistin. Piglets weaned at 28 day were randomly assigned to four groups treated with a control ration, or supplemented with 250 mg/kg proanthocyanidins, kitasamycin/colistin, or 250 mg/kg proanthocyanidins and half-dose antibiotics, respectively...
November 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27876274/are-there-any-ways-around-the-exposure-limiting-nephrotoxicity-of-the-polymyxins
#8
Jason M Pogue, Jessica K Ortwine, Keith S Kaye
The polymyxins (colistin and polymyxin B) have emerged over the past 20 years as essential antibacterial agents that often are the only remaining active class against troublesome multidrug-resistant Gram-negative bacilli such as carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacteriaceae. The utility of this class is limited by its dose-dependent nephrotoxicity, which can occur in more than one-half of patients receiving therapy with either agent. Strategies are urgently needed to optimise the use of this class of agents to ensure optimal activity while minimising the treatment-limiting nephrotoxicity...
November 11, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27873028/mcr-modern-colistin-resistance
#9
REVIEW
I Caniaux, A van Belkum, G Zambardi, L Poirel, M F Gros
Recently, plasmid-mediated and, therefore, transferable bacterial polymyxin resistance was discovered in strains from both humans and animals. Such a trait may widely spread geographically, while simultaneously crossing microbial species barriers. This may ultimately render the "last resort" polymyxin antibiotics therapeutically useless. Colistin is currently used to treat infections caused by Gram-negative carbapenemase producers and colistin resistance may lead to practical pan-antibiotic resistance. We here analyzed the medical and diagnostic consequences of (emerging) colistin resistance and propose pathways toward adequate diagnostics for timely detection of both asymptomatic carriage and infection...
November 21, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27872721/the-role-of-fibroblast-growth-factor-receptor-2-fgfr2-in-differentiation-of-bovine-spermatogonial-stem-cells-scc
#10
Rahem Khoshbakht, Mohammad Tabatabaei, Saeid Hoseinzadeh, Mojtaba Mojtaba, Hesamaddin Shirzad Aski, Enayat Berizi
Although poultry meat is considered as the main source for human Campylobacter infections, there is limited information about non-poultry sources. The present study was aimed to investigate the prevalence and the antibiotic resistance of thermophilic Campylobacter spp. in fecal samples of the cattle and sheep in Shiraz, Iran. A total of 302 fecal samples were obtained from clinically healthy, slaughtered cattle and sheep from Shiraz slaughterhouse. The animals were clinically healthy before being slaughtered...
2016: Veterinary Research Forum
https://www.readbyqxmd.com/read/27872182/an-ompr-envz-two-component-system-ortholog-regulates-phase-variation-osmotic-tolerance-motility-and-virulence-in-acinetobacter-baumannii-strain-ab5075
#11
Kyle A Tipton, Philip N Rather
: Recently, a novel phase-variable colony opacity phenotype was discovered in Acinetobacter baumannii strain AB5075, where colonies interconvert between opaque and translucent variants. Opaque colonies become mottled/sectored after 24 hours of growth due to translucent variants arising within the colony. This easily distinguishable opaque colony phenotype was used to screen for random transposon insertions that increased the frequency of sectoring at a time point when wild-type colonies were uniformly opaque...
November 21, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27872110/correction-for-leangapichart-et-al-acquisition-of-mcr-1-plasmid-mediated-colistin-resistance-in-escherichia-coli-and-klebsiella-pneumoniae-during-hajj-2013-and-2014
#12
Thongpan Leangapichart, Philippe Gautret, Philippe Brouqui, Ziad A Memish, Didier Raoult, Jean-Marc Rolain
No abstract text is available yet for this article.
December 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27872080/classical-%C3%AE-lactamase-inhibitors-potentiate-the-activity-of-daptomycin-against-methicillin-resistant-staphylococcus-aureus-and-colistin-against-acinetobacter-baumannii
#13
George Sakoulas, Warren Rose, Andrew Berti, Joshua Olson, Jason Mungia, Poochit Nonejuie, Eleanna Sakoulas, Michael J Rybak, Joseph Pogliano, Victor Nizet
We asked whether beta-lactamase inhibitors (BLIs) increased the activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus (MRSA), peptide antibiotic colistin (COL) against emerging Gram-negative nosocomial pathogen Acinetobacter baumannii, and human host defense peptide cathelicidin LL37 against either pathogen. DAP and LL37 kill curves were performed with or without BLIs against MRSA, vancomycin-intermediate S. aureus (VISA) and heterogeneous-VISA (hVISA). COL and LL37 kill curves were performed against A...
November 21, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27867554/tigecycline-combination-for-ventilator-associated-pneumonia-caused-by-extensive-drug-resistant-acinetobacter-baumannii
#14
Hangyong He, Yali Zheng, Bing Sun, Xiao Tang, Rui Wang, Zhaohui Tong
BACKGROUND: Extensive drug-resistant Acinetobacter baumannii (XDR A. baumannii) has emerged as an important pathogen in patients with ventilator-associated pneumonia (VAP) worldwide. This study determined whether or not combination tigecycline (TGC) treatment improved the short-term outcome of patients with XDR A. baumannii-induced VAP. Methods: Fifty-eight patients admitted to our intensive care unit (ICU) with confirmed XDR A. baumannii VAP between January 2011 and June 2013 were retrospectively studied...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27865627/epidemiology-of-infections-caused-by-polymyxin-resistant-pathogens
#15
Helen Giamarellou
Confronting the storm of carbapenemase-producing Gram-negative pathogens and thus facing the threat of untreatable infections, the medical community revived colistin. Not long since its re-introduction and despite the fact that resistance to colistin at least in Escherichia coli is rare, chromosomally-mediated colistin resistance in metallo-β-lactamase-producing Klebsiella pneumoniae strains was reported in 2004 from Greece. Subsequent studies revealed the highest predominance in Italy (38%) and Greece (26%), with colistin-resistant (Col-R) strains frequently carrying a carbapenemase...
November 10, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27865626/synergistic-combinations-of-polymyxins
#16
Justin R Lenhard, Roger L Nation, Brian T Tsuji
The proliferation of extensively drug-resistant Gram-negative pathogens has necessitated the therapeutic use of colistin and polymyxin B. However, treatment failures with polymyxin monotherapies and the emergence of polymyxin resistance have catalysed the search for polymyxin combinations that synergistically kill polymyxin-susceptible and -resistant organisms. This mini-review examines recent (2011-2016) in vitro and in vivo studies that have attempted to identify synergistic polymyxin combinations against Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii...
October 24, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27856109/colistin-loading-dose-enhanced-antimicrobial-activity-for-in%C3%A2-vivo-mouse-thigh-infection-model-with-pseudomonas-aeruginosa-with-highly-antimicrobial-resistant
#17
Mao Hagihara, Hideo Kato, Jun Hirai, Naoya Nishiyama, Yusuke Koizumi, Daisuke Sakanashi, Hiroyuki Suematsu, Yuka Yamagishi, Hiroshige Mikamo
This is the first report to test the loading dosage of colistin against Pseudomonas aeruginosa, including MDRP. Using in vivo murine thigh infection model, in the loading dosage regimen (Day 1:50 mg/kg q12 h, Day 2-3: 25 mg/kg q12 h) group, 5 to 6 log10 CFU/ml reduction compared with control were observed for both strains of P. aeruginosa with colistin MIC 0.5 and 1 μg/mL at 72 h. But, similar reduction was observed for the strains with colistin MIC 0.5 μg/mL only in normal dosage regimen (Day 1-3: 25 mg/kg q12 h) group...
November 15, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27855074/emergence-of-colistin-resistance-gene-mcr-1-in-cronobacter-sakazakii-producing-ndm-9-and-escherichia-coli-from-the-same-animal
#18
Bao-Tao Liu, Feng-Jing Song, Ming Zou, Zhi-Hui Hao, Hu Shan
We report the presence of mcr-1 in E. coli and carbapenem-resistant Cronobacter sakazakii, from the same diseased chicken. The mcr-1gene linked with ISApl1 was located on two different IncI2 plasmids including one multidrug plasmid in E. coli, whereas blaNDM-9-fosA3 was on a IncB/O plasmid in C. sakazakii The development of fosA3-blaNDM-9 resistance region was mediated by IS26 The co-location of mcr-1 or blaNDM-9with other resistance genes will accelerate the dissemination of the two genes.
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27855068/prevalence-of-colistin-resistance-gene-mcr-1-and-absence-of-mcr-2-in-escherichia-coli-isolated-from-healthy-food-producing-animals-in-japan
#19
Michiko Kawanishi, Hitoshi Abo, Manao Ozawa, Mariko Uchiyama, Takahiro Shirakawa, Satowa Suzuki, Ayaka Shima, Akifumi Yamashita, Tsuyoshi Sekizuka, Kengo Kato, Makoto Kuroda, Ryoji Koike, Mayumi Kijima
We screened mcr-1 and mcr-2 genes in 9,306 Escherichia coli strains isolated from healthy animals in the Japanese Veterinary Antimicrobial Resistance Monitoring system (JVARM). mcr-1 was detected in 39 strains (5, 20, and 14 isolated from cattle, swine and broiler, respectively), whereas mcr-2 was not detected. mcr-2 was also not detected with the investigation sequence homology search against our curated GenEpid-J database.
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27855065/prevalence-of-mcr-1-in-us-food-animal-cecal-contents
#20
Richard J Meinersmann, Scott R Ladely, Jodie R Plumblee, Kimberly L Cook, Eileen Thacker
A survey of 2003 cecal content samples from chickens, turkeys, cattle and swine at slaughter facilities in the United States was conducted to estimate the prevalence of mcr-1 gene conferring resistance to colistin in Enterobacteriaceae Two cecal samples from swine had Escherichia coli with IncI2 plasmids bearing the mcr-1 gene.
November 14, 2016: Antimicrobial Agents and Chemotherapy
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