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Colistin resistant

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https://www.readbyqxmd.com/read/29238934/treatment-outcome-of-non-carbapenemase-producing-carbapenem-resistant-klebsiella-pneumoniae-infections-a-multicenter-study-in-taiwan
#1
Chin-Fang Su, Chien Chuang, Yi-Tsung Lin, Yu-Jiun Chan, Jung-Chung Lin, Po-Liang Lu, Ching-Tai Huang, Jann-Tay Wang, Yin-Ching Chuang, L Kristopher Siu, Chang-Phone Fung
Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections are associated with high mortality, and experiences with its treatment are usually based on carbapenemase-producing strains. Non-carbapenemase-producing CRKP is of clinical significance, but relevant studies are lacking. This nationwide study aimed to evaluate the outcome of antimicrobial therapy in patients with non-carbapenemase-producing CRKP infections. Patients with non-carbapenemase-producing CRKP infections were enrolled from 16 hospitals during January 2013 to December 2014 in Taiwan...
December 14, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29238331/sensitive-and-rapid-detection-of-the-plasmid-encoded-colistin-resistance-gene-mcr-1-in-enterobacteriaceae-isolates-by-loop-mediated-isothermal-amplification
#2
Dayang Zou, Simo Huang, Hong Lei, Zhan Yang, Yuxin Su, Xiaoming He, Qinghe Zhao, Yong Wang, Wei Liu, Liuyu Huang
The emergence of the plasmid-encoded colistin-resistance gene mcr-1 in Enterobacteriaceae represents a new threat to the treatment of infection in the clinical setting. A sensitive and rapid molecular method for detection of the mcr-1 gene in clinical isolates is needed to control the spread of this gene. In this study, we established a loop-mediated isothermal amplification (LAMP) assay for rapid detection of the mcr-1 gene. This assay was applied to cultured bacteria and spiked human stools. Real-time monitoring of turbidity and chromogenic visualization were used to assess the reaction results...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29237785/mcr-3-and-mcr-4-variants-in-carbapenemase-producing-clinical-enterobacteriaceae-do-not-confer-phenotypic-polymyxin-resistance
#3
Jeanette W P Teo, Marimuthu Kalisvar, Indumathi Venkatachalam, Ng Oon Tek, Raymond T P Lin, Sophie Octavia
The world-wide distribution of plasmid-mediated colistin resistance determinants (mcr-1, mcr-2, mcr-3 and mcr-4) coupled to an emerging observation that colistin resistance is more prevalent in carbapenem-resistant Enterobacteriaceae (CRE) (1, 2) present a daunting challenge in combatting antimicrobial resistance. Undoubtedly, next-generation sequencing approaches have expedited the discovery of mobile colistin resistance determinants (3).….
December 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29235137/development-of-hplc-with-fluorescent-detection-using-nbd-f-for-the-quantification-of-colistin-sulfate-in-rat-plasma-and-its-pharmacokinetic-applications
#4
Sui Ouchi, Kazuaki Matsumoto, Maki Okubo, Yuta Yokoyama, Junko Kizu
Colistin sulfate, composed of a mixture of colistin A sulfate (CLA) and colistin B sulfate (CLB), is available for treating life-threatening infections caused by multidrug-resistant Gram-negative bacteria. In this study, the CLA and CLB were quantified separately. Colistin sulfate was extracted from rat plasma with a solid-phase extraction C18 cartridge and reacted with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F), and the fluorescent derivatives were subjected to reversed phase high-performance liquid chromatography analysis and used to investigate the pharmacokinetics of CLA and CLB in rat plasma...
December 12, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29233990/balancing-mcr-1-expression-and-bacterial-survival-is-a-delicate-equilibrium-between-essential-cellular-defence-mechanisms
#5
Qiue Yang, Mei Li, Owen B Spiller, Diego O Andrey, Philip Hinchliffe, Hui Li, Craig MacLean, Pannika Niumsup, Lydia Powell, Manon Pritchard, Andrei Papkou, Yingbo Shen, Edward Portal, Kirsty Sands, James Spencer, Uttapoln Tansawai, David Thomas, Shaolin Wang, Yang Wang, Jianzhong Shen, Timothy Walsh
MCR-1 is a lipid A modifying enzyme that confers resistance to the antibiotic colistin. Here, we analyse the impact of MCR-1 expression on E. coli morphology, fitness, competitiveness, immune stimulation and virulence. Increased expression of mcr-1 results in decreased growth rate, cell viability, competitive ability and significant degradation in cell membrane and cytoplasmic structures, compared to expression of catalytically inactive MCR-1 (E246A) or MCR-1 soluble component. Lipopolysaccharide (LPS) extracted from mcr-1 strains induces lower production of IL-6 and TNF, when compared to control LPS...
December 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29229637/elucidating-the-pharmacokinetics-pharmacodynamics-of-aerosolized-colistin-against-multidrug-resistant-acinetobacter-baumannii-and-klebsiella-pneumoniae-in-a-mouse-lung-infection-model
#6
Yu-Wei Lin, Qi Tony Zhou, Mei-Ling Han, Ke Chen, Nikolas J Onufrak, Jiping Wang, John D Turnidge, Benjamin P Howden, Alan Forrest, Hak-Kim Chan, Jian Li
Pharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic mouse lung infection model. Dose fractionation studies were performed over 2.64 to 23.8 mg/kg/day, and the data were fitted to a sigmoid inhibitory model. AUC/MIC in the epithelial lining fluid was the most predictive PK/PD index for aerosolized colistin against both pathogens. Our study provides important pharmacological information for optimizing aerosolized colistin...
December 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29229634/genomic-insights-into-colistin-resistant-klebsiella-pneumoniae-from-a-tunisian-teaching-hospital
#7
Nadia Jaidane, Rémy A Bonnin, Wejdene Mansour, Delphine Girlich, Elodie Creton, Garance Colleton, Cherifa Chaouch, Noureddine Boujaafar, Olfa Bouallegue, Thierry Naas
The emergence of colistin-resistant Klebsiella pneumoniae (CoRKp) is a public health concern since this antibiotic has become the last line of treatment for infections caused by multidrug-resistant (MDR) gram-negatives. In this study, we have investigated the molecular basis of colistin-resistance in 13 MDR Kp isolated from 12 patients in a teaching hospital in Sousse, Tunisia. Whole-genome sequencing (WGS) was used to decipher the molecular mechanism of colistin-resistance and to identify the resistome of these CoRKp It revealed a genome of ca...
December 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29228825/efficacy-and-nephrotoxicity-associated-with-various-colistin-dosing-schemas-for-the-treatment-of-multidrug-resistant-mdr-infections
#8
Aiman Bandali, Tiffany E Bias
No abstract text is available yet for this article.
December 12, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29227182/first-report-of-the-plasmid-mediated-colistin-resistance-gene-mcr-1-in-escherichia-coli-st405-isolated-from-wildlife-in-bejaia-algeria
#9
Taous Bachiri, Rym Lalaoui, Sofiane Bakour, Meriem Allouache, Nadia Belkebla, Jean Marc Rolain, Abdelaziz Touati
BACKGROUND: The aim of the present study was to screen for the presence of mcr-1 gene in Enterobacteriaceae isolated from Barbary macaques (Macaca sylvanus) in Algeria. MATERIALS AND METHODS: From January to April 2016, a total of 86 fresh stool samples from Barbary macaques were collected in the Toudja forest (Bejaia, Algeria). After isolation, the isolates were identified by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry. Antibiotic susceptibility was determined by disk diffusion method, and minimum inhibitory concentration (MIC) of colistin was determined by E-test...
December 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29225477/molecular-evaluation-of-colistin-resistant-gene-expression-changes-in-acinetobacter-baumannii-with-real-time-polymerase-chain-reaction
#10
Shahriar Sepahvand, Mohammad Ali Davarpanah, Amir Roudgari, Abbas Bahador, Vajihe Karbasizade, Zahra Kargar Jahromi
Background: Acinetobacter baumannii is an important human pathogen which has recently gained increased attention due to the occurrence of drug-resistant nosocomial infections in patients suffering from immune system disorders, and those in hospital intensive care units. The aim of this research was to identify and isolate A. baumannii strains resistant to colistin, determine antibiotic resistance pattern of this bacteria, investigate the presence of colistin-resistant genes, and finally assess the effect of expression changes in pmrA and pmrB genes resistant to A...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29225413/outbreak-of-hospital-infection-from-biofilm-embedded-pan-drug-resistant-pseudomonas-aeroginosa-due-to-a-contaminated-bronchoscope
#11
Nader Alipour, Alper Karagoz, Abbas Taner, Nasrin Gaeini, Nastaran Alipour, Hassan Zeytin, Fatih Yildiz, Riza Durmaz
Background: Colistin-resistant Pseudomonas aeruginosa (P. aeruginosa) has been defined as pandrug-resistant (PDR) strain. Outbreaks of PDR P. aeruginosa especially in pulmonary tract infections due to contaminated bronchoscopes have rarely been reported. The emergence of pandrug-resistant strains in both CF (Cystic Fibrosis) and non-CF clinical isolates over recent years remains of a great concern. Hospital wards contaminated with PDR P. aeruginosa infection, must be shot down until their eradication...
2017: Tap Chi y Hoc du Phong, Journal of Preventive Medicine / Hoi y Hoc du Phong Viet Nam
https://www.readbyqxmd.com/read/29223516/antimicrobial-activity-of-plazomicin-against-enterobacteriaceae-producing-carbapenemases-from-50-brazilian-medical-centers
#12
Andreza Francisco Martins, Larissa Bail, Carmen Antonia Sanches Ito, Keite da Silva Nogueira, Tanise Vendruscolo Dalmolin, Amanda Silva Martins, Jaime Luis Lopes Rocha, Alisa W Serio, Felipe Francisco Tuon
Plazomicin is a next-generation aminoglycoside with activity against Enterobacteriaceae, including carbapenemase-producing Enterobacteriaceae (CPE). The aim of this study was to evaluate the activity of plazomicin against CPE (Klebsiella spp., Escherichia coli, Serratia spp., Enterobacter spp., Citrobacter spp., Morganella spp., Proteus spp., Providencia spp.) from different Brazilian hospitals. A total of 4000 carbapenem-resistant Enterobacteriaceae isolates were collected from clinical samples in 50 Brazilian hospitals during 2013-2015...
November 10, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29220374/a-blaoxa-181-harbouring-multi-resistant-st147-klebsiella-pneumoniae-isolate-from-pakistan-that-represent-an-intermediate-stage-towards-pan-drug-resistance
#13
Fouzia Nahid, Rabaab Zahra, Linus Sandegren
Carbapenem resistant Klebsiella pneumoniae (CR-KP) infections are an ever-increasing global issue, especially in the Indian subcontinent. Here we report genetic insight into a blaOXA-181 harbouring Klebsiella pneumoniae, belonging to the pandemic lineage ST147, that represents an intermediate stage towards pan-drug resistance. The CR-KP isolate DA48896 was isolated from a patient from Pakistan and was susceptible only to tigecycline and colistin. It harboured blaOXA-181 and was assigned to sequence type ST147...
2017: PloS One
https://www.readbyqxmd.com/read/29217278/colistin-exposure-as-a-risk-factor-for-infections-caused-by-inherently-colistin-resistant-enterobacteriaceae-a-case-control-study
#14
G Drozdinsky, H Ben-Zvi, S Kushnir, L Leibovici, D Yahav
OBJECTIVES: Epidemiological studies have suggested an association between increased colistin use and selection for inherently colistin resistant Enterobacteriaceae (ICRE). We aimed to evaluate whether colistin exposure is a risk factor for ICRE infection. METHODS: A matched 1:1 case-control study including patients recently hospitalized for >=14 days with ICRE infection as cases matched with similar patients with a clinical isolate of a colistin susceptible Enterobacteriaceae as controls was performed...
December 4, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29216906/detection-of-metallo-%C3%AE-lactamases-encoding-genes-among-clinical-isolates-of-pseudomonas-aeruginosa-in-a-tertiary-care-hospital-kathmandu-nepal
#15
Mahesh Acharya, Prabhu R Joshi, Kamal Thapa, Rajan Aryal, Trishna Kakshapati, Supriya Sharma
OBJECTIVES: This study was carried out to determine the prevalence of metallo-β-lactamases (MBLs) producing Pseudomonas aeruginosa in imipenem-nonsusceptible isolates and to detect MBL-encoding genes among MBLs-positive isolates. RESULTS: Metallo-β-lactamases production was detected in 68.6% isolates of P. aeruginosa with reduced susceptibility to imipenem. The bla VIM-2 gene was detected in 75% isolates and bla IMP-1 was detected in 25% isolates. All MBLs-positive isolates were multidrug resistant with a high level of resistance to imipenem (MIC 16 to ≥ 32 µg/ml), meropenem (MIC 16 to ≥ 32 µg/ml), and ceftazidime (MIC 64 to ≥ 512 µg/ml)...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29216350/italian-nationwide-survey-on-pseudomonas-aeruginosa-from-invasive-infections-activity-of-ceftolozane-tazobactam-and-comparators-and-molecular-epidemiology-of-carbapenemase-producers
#16
Tommaso Giani, Fabio Arena, Simona Pollini, Vincenzo Di Pilato, Marco Maria D'Andrea, Lucia Henrici De Angelis, Matteo Bassetti, Gian Maria Rossolini
Objectives: Pseudomonas aeruginosa is a major cause of severe healthcare-associated infections and often shows MDR phenotypes. Ceftolozane/tazobactam is a new cephalosporin/β-lactamase inhibitor combination with potent activity against P. aeruginosa. This survey was carried out to evaluate the susceptibility of P. aeruginosa, circulating in Italy, to ceftolozane/tazobactam and comparators and to investigate the molecular epidemiology of carbapenemase-producing strains. Methods: Consecutive non-replicate P...
December 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29209292/characterization-of-colistin-resistant-escherichia-coli-isolated-from-diseased-pigs-in-france
#17
Sabine Delannoy, Laetitia Le Devendec, Eric Jouy, Patrick Fach, Djamel Drider, Isabelle Kempf
We studied a collection of 79 colistin-resistant Escherichia coli isolates isolated from diseased pigs in France between 2009 and 2013. We determined a number of phenotypic and genetic characters using broth microdilution to characterize their antimicrobial susceptibility. We performed pulse field gel electrophoresis (PFGE) to assess their genetic diversity and assign them to phylogroups. High-throughput real-time PCR micro-array was used to screen for a selection of genetic markers of virulence, and PCR and sequencing of the main recognized resistance genes allowed us to investigate the mechanisms of colistin resistance...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29205192/genetic-diversity-study-of-various-%C3%AE-lactamase-producing-multidrug-resistant-escherichia-coli-isolates-from-a-tertiary-care-hospital-using-eric-pcr
#18
Jayanti Jena, Nagen Kumar Debata, Rajesh Kumar Sahoo, Mahendra Gaur, Enketeswara Subudhi
BACKGROUND & OBJECTIVES: The prevalence of multidrug-resistant (MDR) Escherichia coli isolates producing β-lactamase enzyme is a growing problem across the globe. Strain typing is an epidemiologically important tool not only for detecting the cross transmission of nosocomial pathogens but also for determining the source of infection. The present study was conducted to understand the clonal relationship among various β-lactamase-producing MDR E. coli isolates using enterobacterial repetitive intergenic consensus (ERIC) polymerase chain reaction (PCR)...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29204285/molecular-characterization-of-acinetobacter-baumannii-isolated-from-iraqi-hospital-environment
#19
I M S Al-Kadmy, A N M Ali, I M A Salman, S S Khazaal
Healthcare-associated items are a common source of acquired infections, and hospital-acquired infections cause significant mortality and morbidity worldwide. Acinetobacter baumannii is the most prevalent infection-causing organism in the hospital environment. Hospital articles and objects are the main sources of infection with the ability to transmit some of the pathogenic microorganisms such as A. baumannii, which is considered a serious problem in therapeutic treatments. In the current study, we isolated A...
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29203405/inactivation-of-arn-operon-and-loss-of-aminoarabinose-on-lipopolysaccharide-as-the-cause-of-susceptibility-to-colistin-in-an-atypical-clinical-isolate-of-proteus-vulgaris
#20
Sophie Baron, Zineb Leulmi, Claude Villard, Abiola Olumuyiwa Olaitan, Amar A Telke, Jean-Marc Rolain
Colistin has become a last-line antibiotic for the treatment of multidrug resistant bacterial infections, but resistance to colistin has emerged in recent years. Some bacteria, such as Proteus sp. or Serratia sp., are intrinsically resistant to colistin but the exact mechanism of this resistance is not known. Here, we have identified the molecular support for the intrinsic colistin resistance in Proteus by comparative genomic transcriptomic and proteomic analysis of colistin susceptible (CSUR P1868_S) strain and a colistin resistant (CSUR P1867_R) strain of an atypical Proteus vulgaris...
December 1, 2017: International Journal of Antimicrobial Agents
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