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Colistin resistant

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https://www.readbyqxmd.com/read/28820037/efficacy-and-safety-of-high-loading-dose-of-colistin-in-multidrug-resistant-acinetobacter-baumannii-a-prospective-cohort-study
#1
Wasan Katip, Methisa Meechoui, Phatchawan Thawornwittayakom, Dujrudee Chinwong, Peninnah Oberdorfer
OBJECTIVES: We aimed to assess the efficacy and safety of a high loading dose of colistin and no loading dose of colistin to treat multidrug-resistant (MDR) Acinetobacter baumannii infections. METHODS: We conducted a prospective cohort study of patients with MDR A baumannii infections at a university-affiliated hospital from December 2014 to January 2016. In the high loading dose group, the patients received a high loading dose of 300 mg colistin base activity (CBA) followed by a maintenance dose of 150 mg CBA twice daily, and patients in the no loading dose group received only the maintenance dose...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28818804/an-on-spot-internal-standard-addition-approach-for-accurately-determining-colistin-a-and-colistin-b-in-dried-blood-spots-using-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#2
I-Lin Tsai, Ching-Hua Kuo, Hsin-Yun Sun, Yu-Chung Chuang, Divyabharathi Chepyala, Shu-Wen Lin, Yun-Jung Tsai
Outbreaks of multidrug-resistant Gram-negative bacterial infections have been reported worldwide. Colistin, an antibiotic with known nephrotoxicity and neurotoxicity, is now being used to treat multidrug-resistant Gram-negative strains. In this study, we applied an on-spot internal standard addition approach coupled with an ultra high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantify colistin A and B from dried blood spots (DBSs). Only 15μL of whole blood was required for each sample...
August 3, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28814888/frequency-of-colistin-and-fosfomycin-resistance-in-carbapenem-resistant-enterobacteriaceae-from-a-tertiary-care-hospital-in-karachi
#3
Salima Qamar, Najma Shaheen, Sadia Shakoor, Joveria Farooqi, Kauser Jabeen, Rumina Hasan
INTRODUCTION: Management of infections with carbapenem-resistant Enterobacteriaceae (CRE) is challenging. In recent times, agents such as colistin and fosfomycin have been used in combination with other antibiotics to treat such infections. In this study, we aim to seek frequency of colistin and fosfomycin resistance in CRE from Pakistan. METHODS: This study was conducted at clinical laboratories, Aga Khan University Hospital. In total, 251 CRE were included in the study...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28811346/erratum-for-yin-et-al-novel-plasmid-mediated-colistin-resistance-gene-mcr-3-in-escherichia-coli
#4
Wenjuan Yin, Hui Li, Yingbo Shen, Zhihai Liu, Shaolin Wang, Zhangqi Shen, Rong Zhang, Timothy R Walsh, Jianzhong Shen, Yang Wang
No abstract text is available yet for this article.
August 15, 2017: MBio
https://www.readbyqxmd.com/read/28807425/clinical-outcome-of-dual-colistin-and-carbapenem-resistant-klebsiella-pneumoniae-bloodstream-infections-a-single-center-retrospective-study-of-75-cases-in-india
#5
Amarjeet Kaur, Sumanth Gandra, Priyanka Gupta, Yatin Mehta, Ramanan Laxminarayan, Sharmila Sengupta
In this study, we retrospectively evaluated clinical outcomes of 75 patients with dual colistin- and carbapenem-resistant Klebsiella pneumoniae bloodstream infections over a 5-year period in a single tertiary care hospital in India. We observed a high in-hospital mortality rate of 69.3%. Our findings indicate the urgent need for new antibiotics to treat these infections.
August 11, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28804720/integron-mediated-antibiotic-resistance-in-acinetobacter-baumannii-isolated-from-intensive-care-unit-patients-babol-north-of-iran
#6
Mitra Deylam Salehi, Elaheh Ferdosi-Shahandashti, Yosef Yahyapour, Soraya Khafri, Abazar Pournajaf, Ramazan Rajabnia
BACKGROUND: We investigated the integron types and their relation with antibiotic resistance among A. baumannii isolates collected from intensive care unit patients, Babol, north of Iran. METHODS: In this cross-sectional study, a total of 73 bronchoalveolar lavage samples were obtained from patients in ICU. Susceptibility testing was performed by disk diffusion method. Types of integrons were identified by an integrase gene PCR. RESULTS: In total, 47...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28799833/plasmid-mediated-colistin-resistance-gene-mcr-1-in-an-escherichia-coli-st10-bloodstream-isolate-in-the-sultanate-of-oman
#7
Jalila Mohsin, Tibor Pál, Jorgen Eskild Petersen, Dania Darwish, Akela Ghazawi, Tanveer Ashraf, Agnes Sonnevend
AIMS: To identify plasmid-mediated colistin resistance in clinical Enterobacteriaceae isolates in Oman, where this resistance mechanism has not been encountered yet. MATERIALS/METHODS: Twenty-two colistin-resistant Enterobacteriaceae clinical isolates collected between July 2014 and June 2016 in a tertiary care hospital in Muscat were screened by PCR for the mcr-1 and mcr-2 genes. The strain identified as mcr-1 positive was genotyped and its antibiotic susceptibility was established...
August 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28797329/novel-plasmid-mediated-colistin-resistance-mcr-4-gene-in-salmonella-and-escherichia-coli-italy-2013-spain-and-belgium-2015-to-2016
#8
Alessandra Carattoli, Laura Villa, Claudia Feudi, Ludovica Curcio, Serenella Orsini, Andrea Luppi, Giovanni Pezzotti, Chiara Francesca Magistrali
A novel mcr colistin resistance gene was identified in a strain of Salmonella enterica, monophasic variant of serovar Typhimurium (4,5,12:i:- ), isolated from a pig at slaughter in Italy in 2013, and in Escherichia coli strains collected during routine diagnostic of post-weaning diarrhoea in pigs from Spain and Belgium in 2015 and 2016. Immediate implementation of mcr-screening including this novel gene variant is required for Salmonella and E. coli from humans and food-producing animals in Europe.
August 3, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28797328/co-occurrence-of-colistin-resistance-genes-mcr-1-and-mcr-3-among-multidrug-resistant-escherichia-coli-isolated-from-cattle-spain-september-2015
#9
Marta Hernández, M Rocío Iglesias, David Rodríguez-Lázaro, Alejandro Gallardo, Narciso Quijada, Pedro Miguela-Villoldo, Maria Jorge Campos, Segundo Píriz, Gema López-Orozco, Cristina de Frutos, José Luis Sáez, María Ugarte-Ruiz, Lucas Domínguez, Alberto Quesada
Colistin resistance genes mcr-3 and mcr-1 have been detected in an Escherichia coli isolate from cattle faeces in a Spanish slaughterhouse in 2015. The sequences of both genes hybridised to same plasmid band of ca 250 kb, although colistin resistance was non-mobilisable. The isolate was producing extended-spectrum beta-lactamases and belonged to serotype O9:H10 and sequence type ST533. Here we report an mcr-3 gene detected in Europe following earlier reports from Asia and the United States.
August 3, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28797325/plasmid-borne-colistin-resistance-gene-mcr-3-in-salmonella-isolates-from-human-infections-denmark-2009-17
#10
Eva Litrup, Kristoffer Kiil, Anette M Hammerum, Louise Roer, Eva M Nielsen, Mia Torpdahl
This report describes one Salmonella isolate harbouring both mcr-1 and mcr-3. We also found nine other Salmonella isolates positive for the plasmid-borne colistin resistance gene, mcr-3. The strains were isolated from patients in Denmark between 2009 and 2017 and five of the patients had travelled to Asia. In addition to mcr-3, all strains were found positive for blaTEM-1, strA, strB, sul2 and tet(A) or tet(B), and most strains were positive for blaCTX-M-55 and qnrS.
August 3, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28797324/novel-mcr-3-variant-encoding-mobile-colistin-resistance-in-an-st131-escherichia-coli-isolate-from-bloodstream-infection-denmark-2014
#11
Louise Roer, Frank Hansen, Marc Stegger, Ute Wolff Sönksen, Henrik Hasman, Anette M Hammerum
A novel variant of the plasmid-borne colistin resistance gene mcr-3 was detected on an IncHI2 plasmid in an ST131 CTX-M-55-producing Escherichia coli isolate from a Danish patient with bloodstream infection in 2014. The discovery of novel plasmid-borne genes conferring resistance to colistin is of special interest since colistin has reemerged as an important drug in the treatment of infections with multidrug-resistant Gram-negative bacteria.
August 3, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28797321/plasmid-encoded-colistin-resistance-mcr-one-two-three-and-counting
#12
EDITORIAL
Jan Kluytmans
No abstract text is available yet for this article.
August 3, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28797068/virulence-profiles-and-innate-immune-responses-against-highly-lethal-multidrug-resistant-nosocomial-isolates-of-acinetobacter-baumannii-from-a-tertiary-care-hospital-in-mexico
#13
Roberto Rosales-Reyes, Catalina Gayosso-Vázquez, José Luis Fernández-Vázquez, Ma Dolores Jarillo-Quijada, César Rivera-Benítez, José Ignacio Santos-Preciado, María Dolores Alcántar-Curiel
Virulence profiles and innate immune responses were studied in Acinetobacter baumannii from nosocomial infections collected over one year in a tertiary care hospital in Mexico. A. baumannii were identified by VITEK 2 System followed by susceptibility tests. Carbapenemase genes, active efflux mechanism to imipenem and meropenem and outer membrane proteins profile were analyzed to evaluate their role on the activity of carbapenem resistance. All isolates were genotyped by pulsed field gel electrophoresis. The ability to form biofilm was determined on a polystyrene surface...
2017: PloS One
https://www.readbyqxmd.com/read/28792697/the-first-enterobacter-cloacae-co-producing-ndm-and-oxa-48-carbapenemases-and-interhospital-spread-of-oxa-48-and-ndm-producing-klebsiella-pneumoniae-in-turkey
#14
Demet Haciseyitoglu, Aysegul Dokutan, Ayham Abulaila, Fatma Erdem, Yasemin Cag, Serdar Ozer, Zerrin Aktas
BACKGROUND: The aim of this study was to investigate the occurrence of carbapenemase-producing Enterobacteriaceae. METHODS: A total of 54 carbapenem nonsusceptible Enterobacteriaceae (CRE) isolates were recovered from clinical samples sent to the Dr. Lutfi Kirdar Kartal Training and Research Hospital from the period 2011 through 2014. Forty-four isolates were Klebsiella pneumoniae (CRKP) and the other 10 were Enterobacter cloacae (CREC).The isolate identifications and antibiotic sensitivity tests were performed using a Vitek2 automatic system...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28782705/investigation-of-potential-risk-factors-for-the-occurrence-of-escherichia-coli-isolates-from-german-fattening-pig-farms-harbouring-the-mcr-1-colistin-resistance-gene
#15
Katja Hille, Nicole Roschanski, Inga Ruddat, Johanna Woydt, Maria Hartmann, Uwe Rösler, Lothar Kreienbrock
Within the scope of a cross-sectional investigation on fattening pig farms conducted in 2011 and 2012, 48 fattening farms in different agricultural regions of Germany were studied. Primary cultures of boot swabs and collective faecal samples were stored at -80°C and screened for the presence of the mcr-1 colistin resistance gene. The laboratory results were linked to farm related data collected via questionnaire. We used logistic regression models to investigate the association between occurrence of mcr-1 and farm related data...
August 3, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28780361/untreated-urban-waste-contaminates-indian-river-sediments-with-resistance-genes-to-last-resort-antibiotics
#16
Nachiket P Marathe, Chandan Pal, Swapnil S Gaikwad, Viktor Jonsson, Erik Kristiansson, D G Joakim Larsson
Efficient sewage treatment is critical for limiting environmental transmission of antibiotic-resistant bacteria. In many low and middle income countries, however, large proportions of sewage are still released untreated into receiving water bodies. In-depth knowledge of how such discharges of untreated urban waste influences the environmental resistome is largely lacking. Here, we highlight the impact of uncontrolled discharge of partially treated and/or untreated wastewater on the structure of bacterial communities and resistome of sediments collected from Mutha river flowing through Pune city in India...
July 25, 2017: Water Research
https://www.readbyqxmd.com/read/28780246/detection-and-genetic-features-of-mcr-1-producing-plasmid-in-human-escherichia-coli-infection-in-south-korea
#17
Eun Sil Kim, Yong Pil Chong, Su-Jin Park, Mi-Na Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Jin-Yong Jeong, Yang Soo Kim
The plasmid-mediated colistin resistance gene, mcr-1, was identified for the first time from a hospitalized patient in South Korea. The mcr-1 gene was successfully transferred to E. coli J53 recipient and conferred resistance to colistin in the recipient. The mcr-1-harboring plasmid possessed a typical IncI2 group and did not have the mcr-1-associated ISApl1 element.
July 2, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28780184/emergence-of-a-colistin-resistant-escherichia-coli-clinical-isolate-harboring-mcr-1-in-japan
#18
Tatsuya Tada, Kohei Uechi, Isamu Nakasone, Kayo Shimada, Masashi Nakamatsu, Teruo Kirikae, Jiro Fujita
The mcr-1 is a gene encoding a phosphoethanolamine transferase, which confers resistance to colistin by transferring phosphoethanolamine to lipid A. We describe here the emergence of a colistin-resistant Escherichia coli clinical isolate harboring plasmid-mediated mcr-1 in Japan. The isolate belonged to ST5702 and is suspected to come from livestock and transmitted to human. This is the first report of a clinical isolate harboring mcr-1 in Japan.
August 2, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28780059/a-simple-laboratory-algorithm-for-diagnosis-of-melioidosis-in-resource-constrained-areas-a-study-from-north-central-vietnam
#19
T T Trinh, T S Hoang, D A Tran, V T Trinh, A Göhler, T T Nguyen, S N Hoang, R Krumkamp, L T N Nguyen, J May, P M Doan, C D Do, T A Que, I Steinmetz
OBJECTIVE: Melioidosis may be endemic in many tropical developing countries but diagnosis of the disease is currently unreliable in resource-limited areas. Here we aimed to validate a simple and cheap laboratory algorithm for the identification of Burkholderia pseudomallei from clinical specimens in parts of Vietnam where the disease has not been reported before. METHODS: In June 2015, we conducted training courses at five general hospitals in north central provinces in order to raise awareness of the disease and to introduce a simple and cheap laboratory identification algorithm for B...
August 2, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28777086/1-12%C3%A2-%C3%A3-resolution-crystal-structure-of-the-catalytic-domain-of-the-plasmid-mediated-colistin-resistance-determinant-mcr-2
#20
Katie Coates, Timothy R Walsh, James Spencer, Philip Hinchliffe
MCR-2 confers resistance to colistin, a `last-line' antibiotic against extensively resistant Gram-negative pathogens. It is a plasmid-encoded phosphoethanolamine transferase that is closely related to MCR-1. To understand the diversity in the MCR family, the 1.12 Å resolution crystal structure of the catalytic domain of MCR-2 was determined. Variable amino acids are located distant from both the di-zinc active site and the membrane-proximal face. The exceptionally high resolution will provide an accurate starting model for further mechanistic studies...
August 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
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