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https://www.readbyqxmd.com/read/27611038/haemodynamic-effects-of-parenteral-vs-enteral-paracetamol-in-critically-ill-patients-a-randomised-controlled-trial
#1
S J Kelly, J L Moran, P J Williams, K Burns, A Rowland, J O Miners, S L Peake
Paracetamol is a commonly used drug in the intensive care unit. There have been reports in the literature of an association with significant hypotension, a potentially important interaction for labile critically ill patients. Route of administration may influence the incidence of hypotension. This single-centre, prospective, open-label, randomised, parallel-arm, active-control trial was designed to determine the incidence of hypotension following the administration of paracetamol to critically ill patients...
October 2016: Anaesthesia
https://www.readbyqxmd.com/read/27540194/comparing-oral-paracetamol-doses-in-paediatrics-with-the-new-bnf-c-dosing
#2
Nour Ajjan, Sian Shenton
UNLABELLED: The BNF-C 2014-20151 highlighted some key changes to the dosing of paracetamol in paediatrics, including a change in maximum daily dosage of oral paracetamol from 90 mg/kg/day to 75 mg/kg/day for post-operative pain, and inclusion of age-banded dosing for pain and pyrexia.The local Trust Paediatric Acute Pain Management Manual2 has acknowledged this change, but advised a maximum daily dose of 80 mg/kg/day. This audit was undertaken to determine whether national proposed changes were implemented in practice, in comparison with local guidelines...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27087078/evaluation-of-antipyretic-activity-of-some-medicinal-plants-from-cholistan-desert-pakistan
#3
Muhammad Khurshid Alam, Saeed Ahmed, Shazia Anjum, Muhammad Akram, Syed Muhammad Ali Shah, Hafiz Muhammad Wariss, Khan Usmanghani
Traditional herbal healers "Hakims" use various plants of the Cholistan desert, Pakistan for treating a number of infectious and non-infectious diseases. However, there has never been a scientific validation of these plant-based therapeutics. We compared the antipyretic effect of Echinops echinatus, Alhagi maurorum, Fagonia cretica, Cymbopogon jwarancusa and Panicum turgidum in animal model. These plants were used to reduce E.coli lysate induced pyrexia in rabbits. There were five groups of rabbits having five rabbits in each group...
March 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26977173/analgesic-and-antipyretic-activities-of-methanol-extract-and-its-fraction-from-the-root-of-schoenoplectus-grossus
#4
Nirmal Kumar Subedi, S M Abdur Rahman, Mohammad Ahsanul Akbar
The study aims to evaluate analgesic and antipyretic activities of the methanol extract and its different fractions from root of Schoenoplectus grossus using acetic acid induced writhing and radiant heat tail flick method of pain models in mice and yeast induced pyrexia in rats at the doses of 400 and 200 mg/kg. In acetic acid writhing test, the methanol extract, petroleum ether, and carbon tetrachloride fractions produced significant (P < 0.001 and P < 0.05) inhibition of writhing responses in dose dependent manner...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26900128/antipyretic-analgesic-and-anti-inflammatory-effects-of-kickxia-ramosissima
#5
Shumaila Jan, Muhammad Rashid Khan
ETHNOPHARMACOLOGICAL RELEVANCE: Branched cancerwort, Kickxia ramosissima (Wall.) Janchen (Scrophulariaceae) is traditionally used for the treatment of inflammatory disorders such as rheumatism, diabetes, jaundice and for activation of immune system. Local communities also used this plant for the treatment of spleen enlargement, as febrifuge and in dysmenorrhea. In this investigation antipyretic, analgesic and anti-inflammatory effects of K. ramosissima have been evaluated. METHODS: Dried powder of the whole plant of K...
April 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26678710/the-effect-of-paracetamol-on-core-body-temperature-in-acute-traumatic-brain-injury-a-randomised-controlled-clinical-trial
#6
RANDOMIZED CONTROLLED TRIAL
Manoj K Saxena, Colman Taylor, Laurent Billot, Severine Bompoint, John Gowardman, Jason A Roberts, Jeffery Lipman, John Myburgh
BACKGROUND: Strategies to prevent pyrexia in patients with acute neurological injury may reduce secondary neuronal damage. The aim of this study was to determine the safety and efficacy of the routine administration of 6 grams/day of intravenous paracetamol in reducing body temperature following severe traumatic brain injury, compared to placebo. METHODS: A multicentre, randomised, blind, placebo-controlled clinical trial in adult patients with traumatic brain injury (TBI)...
2015: PloS One
https://www.readbyqxmd.com/read/26506046/alveolar-bone-grafting-donor-site-review-of-100-consecutive-cases-in-cleft-lip-and-palate
#7
Kavit Amin, Wee Sim Khor, Anais Rosich-Medina, Victoria Beale
OBJECTIVE:   Review of patients who underwent secondary alveolar bone grafting for total inpatient stay, postoperative complications, and postoperative analgesic requirements. DESIGN:   Retrospective analysis of medical records. SETTING:   Tertiary care center as part of a regional cleft lip and palate network. PATIENTS:   All patients who underwent secondary alveolar bone grafting from the iliac crest. INTERVENTIONS:   Local anesthetic was infiltrated overlying the anterior iliac crest...
October 27, 2015: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/26333873/experimental-evaluation-of-anti-inflammatory-antinociceptive-and-antipyretic-activities-of-clove-oil-in-mice
#8
Yousef A Taher, Awatef M Samud, Fathy E El-Taher, Ghazala ben-Hussin, Jamal S Elmezogi, Badryia F Al-Mehdawi, Hanan A Salem
BACKGROUND: Clove oil of Eugenia caryophyllata (Myrtaceae) is a light yellowish fluid obtained from dried flower buds. Clove oil is used traditionally to relieve toothache. AIM: The aim of the present work was to study the anti-inflammatory, antinociceptive and antipyretic potential of clove oil in mice. METHODS: Analgesic activity was examined using acetic-acid-induced abdominal constrictions and the hot plate test. Carrageenan-induced paw edema and brewer's-yeast-induced pyrexia were used to investigate the anti-inflammatory activity and the antipyretic effects, respectively...
2015: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/26055261/pharmacological-evidence-for-the-folk-use-of-nefang-antipyretic-anti-inflammatory-and-antinociceptive-activities-of-its-constituent-plants
#9
Protus Arrey Tarkang, Faith A Okalebo, Juma D Siminyu, William N Ngugi, Amos M Mwaura, Jackson Mugweru, Gabriel A Agbor, Anastasia N Guantai
BACKGROUND: Nefang is a polyherbal anti-malarial composed of Mangifera indica ( MiB and MiL; bark and leaf), Psidium guajava ( Pg ), Carica papaya ( Cp ), Cymbopogon citratus ( Cc ), Citrus sinensis ( Cs ) and Ocimum gratissimum ( Og ) (leaves). Previous studies have demonstrated its in vitro and in vivo antiplasmodial activities, antioxidant properties and safety profile. This study aimed at evaluating the antipyretic, anti-inflammatory and antinociceptive activities of the constituent plants of Nefang which are relevant to the symptomatic treatment of malaria fever...
2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/25928288/antipyretic-anti-inflammatory-and-analgesic-activity-of-acacia-hydaspica-r-parker-and-its-phytochemical-analysis
#10
Tayyaba Afsar, Muhammad Rashid Khan, Suhail Razak, Shafi Ullah, Bushra Mirza
BACKGROUND: Inflammation and pain underlies several pathological conditions. Synthetic drugs used for the management of these conditions carry severe toxic effects. Globally efforts are ongoing to introduce novel medicinal plants to develop effective, economic and innocuous drugs. The current study was aimed at investigating the antipyretic, anti-inflammatory and analgesic activity of methanol extract of A. hydaspica aerial parts (AHM) and its active fraction. Furthermore identification and isolation of polyphenolic compounds was carried out to identify the active principles...
April 29, 2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/25878377/effect-of-ethanolic-extracts-of-justicia-neesii-ramam-against-experimental-models-of-pain-and-pyrexia
#11
Nimmakayala Sridhar, Duggirala Suguna Lakshmi, Puchchakayala Goverdhan
OBJECTIVE: The main objective of this study is to evaluate the analgesic and anti-pyretic activities of ethanolic extracts of Justicia neesii Ramam. by different experimental models. MATERIALS AND METHODS: The analgesic activity of plant extract was evaluated against thermal and chemical stimulus induced by Eddy's hot plate and acetic acid respectively in mice. Brewer's yeast induced pyrexia was used to evaluate the antipyretic activity in rats and TAB vaccine induced pyrexia was used to evaluate the antipyretic activity in rabbits...
March 2015: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/25466754/managing-paediatric-patients-with-pyrexia
#12
Emily Wragg, Joseph Francis, Jeshni Amblum
Pyrexia is the most common clinical complaint seen in children by healthcare professionals, yet many parents and professionals cannot recognise the condition and misunderstand antipyretic administration. This article explores the research on the use of antipyretics in children with fever, and compares concomitant and monotherapeutic methods of ibuprofen and paracetamol administration.
December 2014: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/25054915/features-and-management-of-pyrexia-with-combined-dabrafenib-and-trametinib-in-metastatic-melanoma
#13
Clara I Lee, Alexander M Menzies, Lauren E Haydu, Mary Azer, Arthur Clements, Richard F Kefford, Georgina V Long
The combination of dabrafenib and trametinib (CombiDT) is an effective treatment for BRAF-mutant metastatic melanoma; however, over 70% of patients develop drug-related pyrexia, and little is known about this toxicity. We sought to examine the features and management of CombiDT pyrexia. The association between pyrexia and patient demographics, disease characteristics and outcome variables was assessed in patients treated with CombiDT at a single institution. The clinicopathological features of pyrexic events were analysed...
October 2014: Melanoma Research
https://www.readbyqxmd.com/read/25039342/does-paracetamol-help-or-hinder-healing-in-bacterial-infections
#14
REVIEW
Linda Nazarko
Community nursing teams, alongside other primary care services and nurses in working in community hospitals, are caring for people who are older, sicker and require more complex care. The nurse's ability to use evidence to make informed judgements is vitally important to patient care. Nurses often give paracetamol that is prescribed on an 'as required' basis to patients with bacterial infections who are pyrexial. This practice is supported by guidelines from the National Institute of Health and Care Excellence and the British National Formulary...
July 2014: British Journal of Community Nursing
https://www.readbyqxmd.com/read/25015462/antipyretic-activity-of-hydro-alcoholic-extracts-of-moringa-oleifera-in-rabbits
#15
Saeed Ahmad, Syed Muhammad-Ali Shah, Muhammad Khurshid Alam, Khan Usmanghani, Iqbal Azhar, Muhammad Akram
Pyrexia and inflammation are indicatives of various disorders. Modern medicines are available for treatment of pyrexia, but they have few side effects. Several studies are ongoing Worldwide to search natural antipyretic agents with better efficacy and fewer or no side effects. This study was aimed at evaluating the antipyretic activity of Moringa oleifera bark in rabbits against E. coli induced pyrexia. Rectal temperature was recorded with digital thermometer at 0 h and E. coli suspension was injected. After 1 h again rectal temperature of the animals was recorded and hydro-alcoholic extract were administered to the treatment groups and paracetamol hydro-alcoholic 50 mg/kg orally to the positive control group...
July 2014: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/24478997/knowledge-and-practices-of-paracetamol-administration-among-caregivers-of-pediatric-age-group-patients
#16
R P J C Ramanayake, L R Jayasinghe, A H W De Silva, W A T A Wijesinghe, N Kanaganayagam
INTRODUCTION: Paracetamol is a widely used over the counter drug for pyrexia and mild to moderate pain in all age groups. OBJECTIVE: To assess the knowledge and practices of paracetamol administration among caregivers of the pediatric age group patients attending the university family practice. MATERIALS AND METHODS: A clinic-based descriptive cross-sectional survey was carried out among clients attending the family practice of the Faculty of Medicine, University of Kelaniya, Sri Lanka using pretested interviewer administrated questionnaire...
January 2012: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/24448467/arsenic-reduces-the-antipyretic-activity-of-paracetamol-in-rats-modulation-of-brain-cox-2-activity-and-cb%C3%A2-receptor-expression
#17
Karunakaran Vijayakaran, Kandasamy Kannan, Manickam Kesavan, Subramaniyam Suresh, Palanisamy Sankar, Surendra Kumar Tandan, Souvendra Nath Sarkar
We examined whether subacute arsenic exposure can reduce paracetamol-mediated antipyretic activity by affecting COX pathway and cannabinoid CB1 receptor regulation. Rats were preexposed to elemental arsenic (4 ppm) as sodium arsenite through drinking water for 28 days. Next day pyrexia was induced with lipopolysaccharide and paracetamol's (200 mg/kg, oral) antipyretic activity was assessed. The activities of COX-1 and COX-2, the levels of PGE₂, TNF-α and IL-1β and expression of CB₁ receptors were assessed in brain...
January 2014: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/23375211/effects-on-fetal-and-maternal-temperatures-of-paracetamol-administration-during-labour-a-case-control-study
#18
Tony Lavesson, Fernanda Åkerman, Karin Källén, Per Olofsson
OBJECTIVE: To study the effect of paracetamol (acetaminophen) on maternal and fetal temperatures in labour. STUDY DESIGN: From a cohort of 185 women with continuous maternal axillary and fetal scalp temperature recordings in labour, 18 women treated with 1000mg paracetamol orally for pyrexia and 36 untreated controls matched for parity, cervical dilatation, and epidural analgesia were selected. Electronically stored temperature data were analysed offline post hoc...
June 2013: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/22750925/recurrent-kikuchi-fujimoto-disease
#19
Brendan Boyd Spooner, Imdadur Rahman, Nigel Langford, Robin E Ferner
We report the case of a 27-year-old, UK-born, Asian woman who suffered a rare recurrence of Kikuchi-Fujimoto disease. She presented with tender lymphadenopathy of the neck, fever and a prodrome of flu-like symptoms. She had a past medical history of biopsy-proven Kikuchi-Fujimoto disease of her right axilla 2 years earlier, which required no treatment. Following her repeat admission, a cervical lymph node biopsy confirmed a diagnosis of recurrent Kikuchi-Fujimoto disease. She did not improve despite treatment with paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs)...
2010: BMJ Case Reports
https://www.readbyqxmd.com/read/22557254/antipyretic-activity-of-radix-paeoniae
#20
Sapna Motwani, Neelesh Malviya, R K Goel, K R Dutt
The acetone extracts of Radix paeoniae (Paeonaceae) root (100 and 200 mg/kg orally) were tested in brewer's yeast-induced pyrexia in rats to assess their antipyretic activity. The pyrexia in rats was reduced significantly (P < 0.05) compared to that of control. These results indicate that the extracts possess antipyretic properties. The root extract showed significant reduction in normal body temperature and yeast-provoked elevated temperature comparable to that of standard antipyretic drug paracetamol. The antipyretic effect was started at 1h and extended for at least 4h after the drug administration...
July 2007: Ancient Science of Life
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