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pyrexia paracetamol

Suzanne L Parker, Manoj Saxena, John Gowardman, Jeffrey Lipman, John Myburgh, Jason A Roberts
PURPOSE: High-dose paracetamol (6 g/day) is a low-cost intervention that may prevent pyrexia. The purpose of this study was to describe the pharmacokinetics of high-dose intravenous paracetamol, in patients with traumatic brain injury (TBI). MATERIALS AND METHODS: A clinical pharmacokinetic study in adult patients with TBI was performed as a sub-study to a prospective, phase 2B, randomized placebo-controlled study (PARITY). Patients received 1 g of intravenous paracetamol or 0...
May 30, 2018: Journal of Critical Care
Abdulaziz S Saeedan, Indu Singh, Mohd Nazam Ansari, Manjari Singh, Jitendra K Rawat, Uma Devi, Swetlana Gautam, Rajnish K Yadav, Gaurav Kaithwas
The present study was aimed to test the hypothesis that paracetamol (PCM) can precipitate autistic like features when used to counteract vaccine-induced fever using experimental rat pups. The pups were treated with measles mumps rubella (MMR) vaccine, diphtheria tetanus and pertussis (DPT) vaccines and lipopolysaccharide (LPS) with subsequent PCM treatment. The pups were evaluated for postnatal growth (weight gain, eye opening) and behavior alterations (swimming performance, olfactory discrimination, negative geotaxis, nociception, and locomotor activity) by performing battery of neurobehavioral test...
January 11, 2018: Inflammopharmacology
Muhammad Sajid Khan, Abdul Hamid, Muhammad Akram, Sodah Bint Mustafa, Abdul Sami, Syed Muhammad Ali Shah, Khan Usmanghani
The antipyretic effect of the aqueous extract of herbal coded formulation containing equal amount of Salix alba, Emblica officinalis, Glycyrrhiza glabra, Adhatoda vasica, Viola odorata, Thea sinensis, Veleriana officinalis, Foeniculum vulgare, Sisymbrium irrio and Achillea millefolium was investigated using the yeast induced pyrexia model in rabbits. Paracetamol was used as a control group. Rectal temperatures of all rabbits were recorded immediately before the administration of the extract or paracetamol and again at 1 hour, after this, temperature was noted at 1 hrs interval for 5 hrs using digital thermometer...
January 2017: Pakistan Journal of Pharmaceutical Sciences
Wonder Kofi Mensah Abotsi, Stanley Benjamin Lamptey, Eric Boakye-Gyasi, Eric Woode
ETHNOPHARMACOLOGICAL RELEVANCE: The root extract of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) is traditionally used in the management of pain and fever. However, little scientific data exists in literature to support its use. AIM OF STUDY: The present study evaluated the anti-nociceptive and antipyretic properties of the hydroethanolic extract of the roots of Albizia zygia in animal models. MATERIALS AND METHODS: The analgesic effects were investigated in chemical (acetic acid-induced abdominal writhing and formalin tests), thermal (tail-immersion test) and mechanical (carrageenan-induced hyperalgesia) pain models...
March 6, 2017: Journal of Ethnopharmacology
Niaz Ali, Mohammad Shaoib, Syed Wadood Ali Shah, Ismail Shah, Muhammad Shuaib
BACKGROUND: As aerial parts of Rubus ulmifolius contains phytochemicals like flavonoids and tannins. And whereas flavonoids and tannins have antioxidant and antipyretic activity, hence, current work is carried out to screen crude methanolic extract of aerial parts of Rubus ulmifolius (Ru.Cr) and crude flavonoids rich extract of Rubus ulmifolius (Ru.F) for possible antioxidant and antipyretic activity. Ru.Cr and Ru.F are also tested for brine shrimps lethality bioassay. Ru.F is tested for the first time for possible antioxidant and antipyretic activity...
January 19, 2017: BMC Complementary and Alternative Medicine
Wonder Kofi Mensah Abotsi, Stanley Benjamin Lamptey, Stephen Afrane, Eric Boakye-Gyasi, Ruth Uwa Umoh, Eric Woode
CONTEXT: The leaves of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) are used in Ghanaian traditional medicine for the treatment of pain, inflammatory disorders and fever (including malaria). OBJECTIVES: The present study evaluated the anti-inflammatory, antipyretic and analgesic effects of the hydroethanol leaf extract of Albizia zygia (AZE) in animal models. MATERIALS AND METHODS: The anti-inflammatory and antipyretic effects of AZE were examined in the carrageenan-induced foot oedema model and the baker's yeast-induced pyrexia test respectively...
December 2017: Pharmaceutical Biology
S J Kelly, J L Moran, P J Williams, K Burns, A Rowland, J O Miners, S L Peake
Paracetamol is a commonly used drug in the intensive care unit. There have been reports in the literature of an association with significant hypotension, a potentially important interaction for labile critically ill patients. Route of administration may influence the incidence of hypotension. This single-centre, prospective, open-label, randomised, parallel-arm, active-control trial was designed to determine the incidence of hypotension following the administration of paracetamol to critically ill patients...
October 2016: Anaesthesia
Nour Ajjan, Sian Shenton
UNLABELLED: The BNF-C 2014-20151 highlighted some key changes to the dosing of paracetamol in paediatrics, including a change in maximum daily dosage of oral paracetamol from 90 mg/kg/day to 75 mg/kg/day for post-operative pain, and inclusion of age-banded dosing for pain and pyrexia.The local Trust Paediatric Acute Pain Management Manual2 has acknowledged this change, but advised a maximum daily dose of 80 mg/kg/day. This audit was undertaken to determine whether national proposed changes were implemented in practice, in comparison with local guidelines...
September 2016: Archives of Disease in Childhood
Muhammad Khurshid Alam, Saeed Ahmed, Shazia Anjum, Muhammad Akram, Syed Muhammad Ali Shah, Hafiz Muhammad Wariss, Khan Usmanghani
Traditional herbal healers "Hakims" use various plants of the Cholistan desert, Pakistan for treating a number of infectious and non-infectious diseases. However, there has never been a scientific validation of these plant-based therapeutics. We compared the antipyretic effect of Echinops echinatus, Alhagi maurorum, Fagonia cretica, Cymbopogon jwarancusa and Panicum turgidum in animal model. These plants were used to reduce E.coli lysate induced pyrexia in rabbits. There were five groups of rabbits having five rabbits in each group...
March 2016: Pakistan Journal of Pharmaceutical Sciences
Nirmal Kumar Subedi, S M Abdur Rahman, Mohammad Ahsanul Akbar
The study aims to evaluate analgesic and antipyretic activities of the methanol extract and its different fractions from root of Schoenoplectus grossus using acetic acid induced writhing and radiant heat tail flick method of pain models in mice and yeast induced pyrexia in rats at the doses of 400 and 200 mg/kg. In acetic acid writhing test, the methanol extract, petroleum ether, and carbon tetrachloride fractions produced significant (P < 0.001 and P < 0.05) inhibition of writhing responses in dose dependent manner...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Shumaila Jan, Muhammad Rashid Khan
ETHNOPHARMACOLOGICAL RELEVANCE: Branched cancerwort, Kickxia ramosissima (Wall.) Janchen (Scrophulariaceae) is traditionally used for the treatment of inflammatory disorders such as rheumatism, diabetes, jaundice and for activation of immune system. Local communities also used this plant for the treatment of spleen enlargement, as febrifuge and in dysmenorrhea. In this investigation antipyretic, analgesic and anti-inflammatory effects of K. ramosissima have been evaluated. METHODS: Dried powder of the whole plant of K...
April 22, 2016: Journal of Ethnopharmacology
Manoj K Saxena, Colman Taylor, Laurent Billot, Severine Bompoint, John Gowardman, Jason A Roberts, Jeffery Lipman, John Myburgh
BACKGROUND: Strategies to prevent pyrexia in patients with acute neurological injury may reduce secondary neuronal damage. The aim of this study was to determine the safety and efficacy of the routine administration of 6 grams/day of intravenous paracetamol in reducing body temperature following severe traumatic brain injury, compared to placebo. METHODS: A multicentre, randomised, blind, placebo-controlled clinical trial in adult patients with traumatic brain injury (TBI)...
2015: PloS One
Kavit Amin, Wee Sim Khor, Anais Rosich-Medina, Victoria Beale
OBJECTIVE:   Review of patients who underwent secondary alveolar bone grafting for total inpatient stay, postoperative complications, and postoperative analgesic requirements. DESIGN:   Retrospective analysis of medical records. SETTING:   Tertiary care center as part of a regional cleft lip and palate network. PATIENTS:   All patients who underwent secondary alveolar bone grafting from the iliac crest. INTERVENTIONS:   Local anesthetic was infiltrated overlying the anterior iliac crest...
March 2017: Cleft Palate-craniofacial Journal
Yousef A Taher, Awatef M Samud, Fathy E El-Taher, Ghazala ben-Hussin, Jamal S Elmezogi, Badryia F Al-Mehdawi, Hanan A Salem
BACKGROUND: Clove oil of Eugenia caryophyllata (Myrtaceae) is a light yellowish fluid obtained from dried flower buds. Clove oil is used traditionally to relieve toothache. AIM: The aim of the present work was to study the anti-inflammatory, antinociceptive and antipyretic potential of clove oil in mice. METHODS: Analgesic activity was examined using acetic-acid-induced abdominal constrictions and the hot plate test. Carrageenan-induced paw edema and brewer's-yeast-induced pyrexia were used to investigate the anti-inflammatory activity and the antipyretic effects, respectively...
2015: Libyan Journal of Medicine
Protus Arrey Tarkang, Faith A Okalebo, Juma D Siminyu, William N Ngugi, Amos M Mwaura, Jackson Mugweru, Gabriel A Agbor, Anastasia N Guantai
BACKGROUND: Nefang is a polyherbal anti-malarial composed of Mangifera indica ( MiB and MiL; bark and leaf), Psidium guajava ( Pg ), Carica papaya ( Cp ), Cymbopogon citratus ( Cc ), Citrus sinensis ( Cs ) and Ocimum gratissimum ( Og ) (leaves). Previous studies have demonstrated its in vitro and in vivo antiplasmodial activities, antioxidant properties and safety profile. This study aimed at evaluating the antipyretic, anti-inflammatory and antinociceptive activities of the constituent plants of Nefang which are relevant to the symptomatic treatment of malaria fever...
2015: BMC Complementary and Alternative Medicine
Tayyaba Afsar, Muhammad Rashid Khan, Suhail Razak, Shafi Ullah, Bushra Mirza
BACKGROUND: Inflammation and pain underlies several pathological conditions. Synthetic drugs used for the management of these conditions carry severe toxic effects. Globally efforts are ongoing to introduce novel medicinal plants to develop effective, economic and innocuous drugs. The current study was aimed at investigating the antipyretic, anti-inflammatory and analgesic activity of methanol extract of A. hydaspica aerial parts (AHM) and its active fraction. Furthermore identification and isolation of polyphenolic compounds was carried out to identify the active principles...
April 29, 2015: BMC Complementary and Alternative Medicine
Nimmakayala Sridhar, Duggirala Suguna Lakshmi, Puchchakayala Goverdhan
OBJECTIVE: The main objective of this study is to evaluate the analgesic and anti-pyretic activities of ethanolic extracts of Justicia neesii Ramam. by different experimental models. MATERIALS AND METHODS: The analgesic activity of plant extract was evaluated against thermal and chemical stimulus induced by Eddy's hot plate and acetic acid respectively in mice. Brewer's yeast induced pyrexia was used to evaluate the antipyretic activity in rats and TAB vaccine induced pyrexia was used to evaluate the antipyretic activity in rabbits...
March 2015: Indian Journal of Pharmacology
Emily Wragg, Joseph Francis, Jeshni Amblum
Pyrexia is the most common clinical complaint seen in children by healthcare professionals, yet many parents and professionals cannot recognise the condition and misunderstand antipyretic administration. This article explores the research on the use of antipyretics in children with fever, and compares concomitant and monotherapeutic methods of ibuprofen and paracetamol administration.
December 2014: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
Clara I Lee, Alexander M Menzies, Lauren E Haydu, Mary Azer, Arthur Clements, Richard F Kefford, Georgina V Long
The combination of dabrafenib and trametinib (CombiDT) is an effective treatment for BRAF-mutant metastatic melanoma; however, over 70% of patients develop drug-related pyrexia, and little is known about this toxicity. We sought to examine the features and management of CombiDT pyrexia. The association between pyrexia and patient demographics, disease characteristics and outcome variables was assessed in patients treated with CombiDT at a single institution. The clinicopathological features of pyrexic events were analysed...
October 2014: Melanoma Research
Linda Nazarko
Community nursing teams, alongside other primary care services and nurses in working in community hospitals, are caring for people who are older, sicker and require more complex care. The nurse's ability to use evidence to make informed judgements is vitally important to patient care. Nurses often give paracetamol that is prescribed on an 'as required' basis to patients with bacterial infections who are pyrexial. This practice is supported by guidelines from the National Institute of Health and Care Excellence and the British National Formulary...
July 2014: British Journal of Community Nursing
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