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cholangitis review

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https://www.readbyqxmd.com/read/29655972/effectiveness-and-safety-of-anti-tnf-therapy-for-inflammatory-bowel-disease-in-liver-transplant-recipients-for-primary-sclerosing-cholangitis-a-nationwide-case-series
#1
Romain Altwegg, Roman Combes, David Laharie, Victor De Ledinghen, Sylvie Radenne, Filomena Conti, Olivier Chazouilleres, Christophe Duvoux, Jérôme Dumortier, Vincent Leroy, Xavier Treton, François Durand, Sébastien Dharancy, Maria Nachury, Félix Goutorbe, Géraldine Lamblin, Lucile Boivineau, Laurent Peyrin-Biroulet, Georges-Philippe Pageaux
BACKGROUND: There is a lack of consensus regarding the treatment of inflammatory bowel disease (IBD) after liver transplantation (LT) forprimary sclerosing cholangitis (PSC). AIM: To investigate the safety and effectiveness of anti-TNF therapy in patients with IBD after a LT for PSC. METHODS: We reviewed the medical files of all of the IBD patients who underwent a LT for PSC and who were treated with anti-TNF therapy at 23 French liver transplantation centers between 1989 and 2012...
March 13, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29655526/association-between-appendectomy-and-risk-of-primary-sclerosing-cholangitis-a-systematic-review-and-meta-analysis
#2
Karn Wijarnpreecha, Panadeekarn Panjawatanan, Omar Y Mousa, Wisit Cheungpasitporn, Surakit Pungpapong, Patompong Ungprasert
BACKGROUND/OBJECTIVES: Recent epidemiologic studies have suggested that appendectomy could be a risk factor for primary sclerosing cholangitis (PSC) although the results were inconsistent. This systematic review and meta-analysis was conducted to summarize all available evidence. METHODS: A comprehensive literature review was conducted using MEDLINE and EMBASE database through January 2018 to identify all studies that reported the risk of PSC among individuals who had appendectomy versus those with no history of appendectomy...
April 11, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29649951/biliary-ascariasis-presenting-with-gangrenous-perforation-of-the-gall-bladder-report-of-a-case-and-brief-review-of-literature
#3
Ankush Sharma, Priyansh Jariwala, Navneet Kaur
The most common cause of gallbladder perforation is calculous cholecystitis. Rarer causes include trauma, iatrogenic injuries, biliary stasis and gall bladder ischemia. We report a case of gall bladder gangrene with perforation, secondary to extensive ascariasis. A 45-year-old woman presented with acute intestinal obstruction and jaundice. She had abdominal distension and right hypochondrial tenderness. Abdominal radiography showed dilated bowel loops and ultrasonogram showed worms in the small intestine and biliary tree...
January 1, 2018: Tropical Doctor
https://www.readbyqxmd.com/read/29626258/mr-elastography-in-primary-sclerosing-cholangitis-correlating-liver-stiffness-with-bile-duct-strictures-and-parenchymal-changes
#4
Candice A Bookwalter, Sudhakar K Venkatesh, John E Eaton, Thomas D Smyrk, Richard L Ehman
AIM: To determine correlation of liver stiffness measured by MR Elastography (MRE) with biliary abnormalities on MR Cholangiopancreatography (MRCP) and MRI parenchymal features in patients with primary sclerosing cholangitis (PSC). METHODS: Fifty-five patients with PSC who underwent MRI of the liver with MRCP and MRE were retrospectively evaluated. Two board-certified abdominal radiologists in agreement reviewed the MRI, MRCP, and MRE images. The biliary tree was evaluated for stricture, dilatation, wall enhancement, and thickening at segmental duct, right main duct, left main duct, and common bile duct levels...
April 7, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29620408/cholangitis-secondary-to-afferent-loop-syndrome-from-a-gastric-stump-adenocarcinoma
#5
Eduardo Valdivielso Cortázar, Javier Redondo Martínez, Gabriela Romay Cousido, Pedro Alonso-Aguirre
A clinical case of an 85-year-old patient with cholangitis secondary to afferent loop syndrome from gastric stump adenocarinoma. A brief review of the literature on it is made.
April 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29607530/systematic-review-drug-induced-liver-injury-alternative-causes-in-case-series-as-confounding-variables
#6
REVIEW
Rolf Teschke, Gaby Danan
AIMS: Drug-induced liver injury (DILI) is rare as compared to the worldwide frequent acute or chronic liver diseases. Therefore, patients included in series of suspected DILI are at high risk of not having DILI, whereby alternative causes may confound the DILI diagnosis. The aim of this review is to evaluate published case series of DILI for alternative causes. METHODS: Pertinent studies were identified using a computerized search of the Medline database for publications from 1993 through 30 October 2017...
April 1, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29603759/hepatic-granulomas-a-17-year-single-tertiary-centre-experience
#7
Rui Gaspar, Patrícia Andrade, Marco Silva, Armando Peixoto, Joanne Lopes, Fátima Carneiro, Rodrigo Liberal, Guilherme Macedo
BACKGROUND: Hepatic granulomas have an estimated prevalence of 5% in liver biopsies, with a wide range of etiologies all over the world. Our aim was to assess the clinical relevance, presenting features and underlying etiology, in a non-transplant, tertiary referral center from a western country. METHODS: Retrospective,single-center, review of clinical, laboratory and histological data including all adult patients from whom a liver biopsy has been performed from January 1998 to December 2014...
March 30, 2018: Histopathology
https://www.readbyqxmd.com/read/29582357/does-time-taken-to-achieve-jaundice-clearance-influence-survival-of-the-native-liver-in-post-kasai-biliary-atresia
#8
Hideaki Nakajima, Hiroyuki Koga, Manabu Okawada, Hiroki Nakamura, Geoffrey James Lane, Atsuyuki Yamataka
BACKGROUND: We reviewed the time taken for post-portoenterostomy (PE) biliary atresia (BA) patients to obtain jaundice-clearance (total bilirubin ≤ 1.2 mg/dL; JC) post-PE to determine if JC time (JCT) is prognostic for survival of the native liver (SNL). METHODS: The subjects were 66 BA patients treated with PE at our institute between 1989, the year when liver transplantation (LTx) became available in Japan, and 2014. JCT was used to create three groups (≤ 30 days: n = 14; 31-60 days: n = 31; ≥ 61 days: n = 21)...
March 26, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29579869/efficacy-and-safety-of-anti-tnf-%C3%AE-agents-in-inflammatory-bowel-disease-after-liver-transplant-a-case-series
#9
R V Olmedo-Martín, V Amo-Trillo, R González-Grande, E Tenorio-González, O Sánchez-García, J de la Cruz-Lombardo, J M Rodrigo-López, M Jiménez-Pérez
BACKGROUND: Ulcerative colitis (UC) and Crohn disease (CD) can appear de novo or worsen after liver transplant. Our aim was to assess the efficacy and safety of anti-tumor necrosis-alpha (anti-TNF-α) agents after transplantation. METHODS: We reviewed the clinical database of our center searching for all liver transplant patients with inflammatory bowel disease who were treated with anti-TNF-α agents between 1997 and 2017. Clinical response was assessed from clinical activity indices 12 weeks after starting treatment...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29576223/gadolinium-based-relative-contrast-enhancement-in-primary-sclerosing-cholangitis-additional-benefit-for-clinicians
#10
S Keller, S K Venkatesh, M Avanesov, J M Weinrich, R Zenouzi, C Schramm, G Adam, J Yamamura
AIM: To evaluate the benefit of extracellular gadolinium-based contrast agent (GBCA) enhanced magnetic resonance imaging (MRI) in addition to conventional non-enhanced T2-weighted imaging (WI) for quantification of inflammatory or fibrotic alterations in the liver parenchyma of patients with primary sclerosing cholangitis (PSC). MATERIAL AND METHODS: MRI (3 T) examinations were reviewed retrospectively by two radiologists in 27 PSC patients (age 42.9±15.6 years), and 19 controls...
March 22, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29574971/design-and-endpoints-for-clinical-trials-in-primary-sclerosing-cholangitis
#11
REVIEW
Cyriel Y Ponsioen, Keith D Lindor, Ruby Mehta, Lara Dimick-Santos
Primary sclerosing cholangitis is a rare and chronic liver disease for which there is no effective therapy. There has been growing interest in developing treatments for this condition with several agents being proposed as potential therapies. However, there is lack of clarity about how to measure clinical benefit in trials in patients with this complex and rare disease. This article reviews regulatory information, the available literature on natural history, as well as potential candidate clinical and surrogate endpoints...
March 25, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29562383/intraductal-papillary-neoplasm-of-the-bile-duct-case-report-and-review-of-the-literature
#12
P Apostolopoulos, K A Ekmektzoglou, K Paraskeva, K Dimopoulos, K Paparaskeva, G Alexandrakis
A variant of bile duct carcinoma, intraductal papillary neoplasm of the bile duct (IPNB) is a rare disease mainly found in Eastern Asia which encompasses a spectrum of intraductal papillary growth occurring anywhere along the intrahepatic and/or extrahepatic biliary tree that carries a high potential for malignancy. We report the case of a patient with episodes of recurrent cholangitis that was diagnosed with IPNB, our clinical and diagnostic approach, the radiographic and endoscopic findings, the interventions used, while discussing the therapeutic options...
January 2018: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29562380/igg4-related-disease-of-the-hepatobiliary-tract-2-case-reports-and-review-of-the-literature
#13
J Spapen, A Reekmans, B Berghmans, S Debeuckelaere, P Buydens, L Trappeniers, B Van den Bossche, I Colle
IgG4-related disease is a rare inflammatory disorder that may mimic many infectious, malignant, and autoimmune conditions. The biliary tract is frequently involved, but hepatic lesions are rarely seen. Diagnosis is often delayed due to the absence of specific clinical and radiological signs, and the lack of an accurate diagnostic marker. Differential diagnosis includes cholangiocarcinoma, primary sclerosing cholangitis and intrinsic or metastatic liver disease. Corticosteroids are the cornerstone of therapy but treatment has not been standardized and relapse is common...
January 2018: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29536837/-new-name-and-new-treatments-for-primary-biliary-cholangitits
#14
Lars Bossen, Henriette Ytting, Peter Jepsen, Ole Hamberg, Peter Ott, Henning Grønbæk
The name of chronic liver disease: primary biliary cirrhosis, has been changed to: primary biliary cholangitis, primarily because of the stigma associated with the word "cirrhosis", as only a minority of the patients develop cirrhosis. In this review we present data on epidemiology and discuss the current treatments with focus on ursodeoxycholic acid and the newly described effects of the farnesoid receptor agonist obeticholic acid.
March 5, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29536035/long-term-prognosis-and-recurrence-of-primary-sclerosing-cholangitis-after-liver-transplantation-a-single-center-experience
#15
Yoshihide Ueda, Toshimi Kaido, Hideaki Okajima, Koichiro Hata, Takayuki Anazawa, Atsushi Yoshizawa, Shintaro Yagi, Kojiro Taura, Toshihiko Masui, Noriyo Yamashiki, Hironori Haga, Miki Nagao, Hiroyuki Marusawa, Hiroshi Seno, Shinji Uemoto
Background: Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease, with liver transplantation being the sole life-saving treatment for end-stage PSC-related liver disease. However, recurrence of PSC after liver transplantation is a common complication, with the risk factors for recurrence being controversial. Methods: We conducted a retrospective chart review of 45 patients who had undergone liver transplantation for PSC at our institute...
December 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29532638/differential-diagnosis-of-cholangiocarcinoma-and-igg4-related-sclerosing-cholangitis-by-fluorescence-in-situ-hybridization-using-transpapillary-forceps-biopsy-specimens
#16
Akihisa Kato, Itaru Naitoh, Katsuyuki Miyabe, Kazuki Hayashi, Hiromu Kondo, Michihiro Yoshida, Hiroyuki Kato, Toshiya Kuno, Satoru Takahashi, Takashi Joh
BACKGROUND: Fluorescence in situ hybridization (FISH) of cytology specimens has been used to diagnose biliary strictures. However, the usefulness of FISH for differentiating between cholangiocarcinoma (CCA) and IgG4-related sclerosing cholangitis (IgG4-SC) has not been evaluated in forceps biopsy specimens. METHODS: We retrospectively reviewed 74 specimens obtained by transpapillary forceps biopsy between 2008 and 2015 from 49 consecutive patients with CCA and 25 with IgG4-SC...
March 2018: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29522170/malignancy-and-mortality-in-pediatric-onset-inflammatory-bowel-disease-a-systematic-review
#17
Martine A Aardoom, Maria E Linda Joosse, Andrica C H de Vries, Arie Levine, Lissy de Ridder
Background: Cancer and death are the most severe outcomes that affect patients with inflammatory bowel disease (IBD). These outcomes are even more severe if they occur at a young age but are rare, even in the general population. We conducted a systematic review to provide an overview of all reported pediatric (PIBD) patients with severe outcome. Methods: A literature search identified publications that reported development of cancer or fatal outcome in PIBD patients...
March 7, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29517637/early-endoscopic-retrograde-cholangiopancreatography-versus-conservative-treatment-in-patients-with-acute-biliary-pancreatitis-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#18
Lara M de A Coutinho, Wanderley M Bernardo, Rodrigo S Rocha, Fabio R Marinho, Aureo Delgado, Eduardo T H Moura, Sergio E Matuguma, Dalton Chaves, Tomazo A P Franzini, Paulo Sakai, Eduardo G H de Moura
OBJECTIVES: The aim of the study was to evaluate the role of early endoscopic retrograde cholangiopancreatography (ERCP) in the treatment of acute biliary pancreatitis, in comparison with conservative treatment. METHODS: Systematic review via databases (MEDLINE [PubMed], Latin-American and Caribbean Health Sciences Literature database, Embase, Cochrane Central, and the [Brazilian] Regional Library of Medicine) is conducted. We analyzed 10 randomized controlled trials (1091 patients)...
April 2018: Pancreas
https://www.readbyqxmd.com/read/29513767/association-of-gadolinium-enhanced-magnetic-resonance-imaging-with-hepatic-fibrosis-and-inflammation-in-primary-sclerosing-cholangitis
#19
Sarah Keller, Annette Aigner, Roman Zenouzi, Anne C Kim, Arnoud Meijer, Sören A Weidemann, Till Krech, Ansgar W Lohse, Gerhard Adam, Christoph Schramm, Jin Yamamura
OBJECTIVE: To evaluate magnetic resonance imaging (MRI) parameters T2 signal, contrast enhancement (CE), and relative liver enhancement (RLE) of extracellular gadolinium-based contrast agent (GBCA)-enhanced MRI as a marker for hepatic fibrosis and inflammation in patients with primary sclerosing cholangitis (PSC). METHODS: 3.0-Tesla MRI scans and liver biopsies of 40 patients (41.2 ± 17.1 years) were retrospectively reviewed. Biopsies were obtained within a mean time of 54 ± 55 days to MRI scans and specimens were categorized according to Ishak modified hepatic activity index (mHAI) and Scheuer staging of fibrosis...
2018: PloS One
https://www.readbyqxmd.com/read/29503645/autoantibodies-in-autoimmune-hepatitis-can-epitopes-tell-us-about-the-etiology-of-the-disease
#20
REVIEW
Urs Christen, Edith Hintermann
Autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are serious autoimmune liver diseases that are characterized by a progressive destruction of the liver parenchyma and/or the hepatic bile ducts and the development of chronic fibrosis. Left untreated autoimmune liver diseases are often life-threatening, and patients require a liver transplantation to survive. Thus, an early and reliable diagnosis is paramount for the initiation of a proper therapy with immunosuppressive and/or anticholelithic drugs...
2018: Frontiers in Immunology
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