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screening motor development

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https://www.readbyqxmd.com/read/29793101/-survey-of-wellbeing-of-young-children-swyc-how-does-it-fit-for-screening-developmental-delay-in-brazilian-children-aged-4-to-58-months
#1
R S Moreira, L C Magalhães, C M Siqueira, C R L Alves
OBJECTIVE: To replicate the original normative study of the SWYC's Milestones Questionnaires for children in Brazil. Our goals were to compare the performance of Brazilian and North American children using this screening tool and to verify the reliability and validity of the Brazilian version. STUDY DESIGN AND SETTING: Cross-sectional study with children aged 1-65 months and their guardians, recruited in southern Brazil. Parents were interviewed using the Developmental Milestones questionnaire, which contains 10 questions about cognitive, motor, social, and language abilities...
May 21, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29770797/correlation-of-the-predisposition-of-chinese-children-to-cerebral-palsy-with-nucleotide-variation-in-pri-mir-124-that-alters-the-non-canonical-apoptosis-pathway
#2
Hui Li, Xiu-Li Wang, Yan-Qiu Wu, Xiu-Mei Liu, Ai-Min Li
Cerebral palsy is a group of non-progressive motor impairment syndromes caused by brain lesions during development. Herein, we investigated the relationship between nucleotide variations in a miRNA coding region and the predisposition of Chinese children to cerebral palsy. A total of 233 CP patients and 256 healthy participants were enrolled, and 60 children were selected from each group for plasma miRNA detection. We screened the coding regions of pri-miR-124-1, -2, and -3 using PCR and sequencing. The expression of miR-124 was determined by qRT-PCR...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29761115/depdc5-knockdown-causes-mtor-dependent-motor-hyperactivity-in-zebrafish
#3
Hortense de Calbiac, Adriana Dabacan, Elise Marsan, Hervé Tostivint, Gabrielle Devienne, Saeko Ishida, Eric Leguern, Stéphanie Baulac, Raul C Muresan, Edor Kabashi, Sorana Ciura
Objective: DEPDC5 was identified as a major genetic cause of focal epilepsy with deleterious mutations found in a wide range of inherited forms of focal epilepsy, associated with malformation of cortical development in certain cases. Identification of frameshift, truncation, and deletion mutations implicates haploinsufficiency of DEPDC5 in the etiology of focal epilepsy. DEPDC5 is a component of the GATOR1 complex, acting as a negative regulator of mTOR signaling. Methods: Zebrafish represents a vertebrate model suitable for genetic analysis and drug screening in epilepsy-related disorders...
May 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29760466/two-photon-imaging-of-neuronal-activity-in-motor-cortex-of-marmosets-during-upper-limb-movement-tasks
#4
Teppei Ebina, Yoshito Masamizu, Yasuhiro R Tanaka, Akiya Watakabe, Reiko Hirakawa, Yuka Hirayama, Riichiro Hira, Shin-Ichiro Terada, Daisuke Koketsu, Kazuo Hikosaka, Hiroaki Mizukami, Atsushi Nambu, Erika Sasaki, Tetsuo Yamamori, Masanori Matsuzaki
Two-photon imaging in behaving animals has revealed neuronal activities related to behavioral and cognitive function at single-cell resolution. However, marmosets have posed a challenge due to limited success in training on motor tasks. Here we report the development of protocols to train head-fixed common marmosets to perform upper-limb movement tasks and simultaneously perform two-photon imaging. After 2-5 months of training sessions, head-fixed marmosets can control a manipulandum to move a cursor to a target on a screen...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29730660/perinatal-outcome-and-long-term-neurodevelopment-after-intracranial-haemorrhage-due-to-fetal-and-neonatal-alloimmune-thrombocytopenia
#5
Dian Winkelhorst, Marije M Kamphuis, Sylke J Steggerda, Monique Rijken, Dick Oepkes, Enrico Lopriore, Jeanine M M van Klink
OBJECTIVES: To evaluate the perinatal and long-term neurodevelopmental outcome in a cohort of children with intracranial haemorrhage (ICH) due to fetal and neonatal alloimmune thrombocytopenia (FNAIT) and to clearly outline the burden of this disease. SUBJECTS AND METHODS: We performed an observational cohort study and included all consecutive cases of ICH caused by FNAIT from 1993 to 2015 at Leiden University Medical Centre. Neurological, motor, and cognitive development were assessed at a minimum age of 1 year...
May 4, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29726749/international-variation-in-programmes-for-assessment-of-children-s-neurodevelopment-in-the-community-understanding-disparate-approaches-to-evaluation-of-motor-social-emotional-behavioural-and-cognitive-function
#6
Philip Wilson, Rachael Wood, Kirsten Lykke, Anette Hauskov Graungaard, Ruth Kirk Ertmann, Merethe Kirstine Andersen, Ole Rikard Haavet, Per Lagerløv, Eirik Abildsnes, Mina P Dahli, Marjukka Mäkelä, Aleksi Varinen, Merja Hietanen
BACKGROUND: Few areas of medicine demonstrate such international divergence as child development screening and surveillance. Many countries have nationally mandated surveillance policies, but the content of programmes and mechanisms for delivery vary enormously. The cost of programmes is substantial but no economic evaluations have been carried out. We have critically examined the history, underlying philosophy, content and delivery of programmes for child development assessment in five countries with comprehensive publicly funded health services (Denmark, Finland, Norway, Scotland and Sweden)...
May 1, 2018: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29722846/high-dose-vitamin-d3-in-the-treatment-of-severe-acute-malnutrition-a-multicenter-double-blind-randomized-controlled-trial
#7
Javeria Saleem, Rubeena Zakar, Muhammad Z Zakar, Mulugeta Belay, Marion Rowe, Peter M Timms, Robert Scragg, Adrian R Martineau
Background: Vitamin D deficiency is common in children with severe acute malnutrition, in whom it is associated with severe wasting. Ready-to-use therapeutic food (the standard treatment) contains modest amounts of vitamin D that do not reliably correct deficiency. Objective: The aim of this study was to determine whether high-dose oral vitamin D3 enhances weight gain and development in children with uncomplicated severe acute malnutrition. Design: We conducted a randomized placebo-controlled trial of high-dose vitamin D3 supplementation in children aged 6-58 mo with uncomplicated severe acute malnutrition in Pakistan...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29718853/pediatric-tuina-for-promoting-growth-and-development-of-preterm-infants-a-protocol-for-the-systematic-review-of-randomized-controlled-trail
#8
Xinghe Zhang, Taipin Guo, Bowen Zhu, Qing Gao, Hourong Wang, Xiantao Tai, Fujie Jing
BACKGROUND: Preterm infants are babies born alive before 37 weeks. Many survived infants concomitant with defects of growth and development, a lifetime of disability usually as following when insufficient intervention. In early intervention of preterm infants, pediatric Tuina shows good effect in many Chinese and some English clinical trials. This systematic review is aimed to evaluate the efficacy and safety of pediatric Tuina for promoting growth and development of preterm infants. METHODS: The electronic databases of Cochrane Library, MEDLINE, EBASE, Web of Science, Springer, World Health Organization International Clinical Trials Registry Platform, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wan-fang database, Chinese Scientific Journal Database, and other databases will be searched from establishment to April 1, 2018...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29718741/high-throughput-behavioral-assay-to-investigate-seizure-sensitivity-in-zebrafish-implicates-zfhx3-in-epilepsy
#9
Tyson D Fuller, Trudi A Westfall, Tirthasree Das, Deborah V Dawson, Diane C Slusarski
Epilepsy, which affects ∼1% of the population, is caused by abnormal synchronous neural activity in the central nervous system (CNS). While there is a significant genetic contribution to epilepsy, the underlying causes for the majority of genetic cases remain unknown. The NIH Undiagnosed Diseases Project (UDP) utilized exome sequencing to identify genetic variants in patients affected by various conditions with undefined etiology, including epilepsy. Confirming the functional relevance of the candidate genes identified by exome sequencing in a timely manner is crucial to translating exome data into clinically useful information...
May 2, 2018: Journal of Neurogenetics
https://www.readbyqxmd.com/read/29702698/comprehensive-behavioral-analysis-of-the-cdkl5-knockout-mice-revealed-significant-enhancement-in-anxiety-and-fear-related-behaviors-and-impairment-in-both-acquisition-and-long-term-retention-of-spatial-reference-memory
#10
Kosuke Okuda, Keizo Takao, Aya Watanabe, Tsuyoshi Miyakawa, Masashi Mizuguchi, Teruyuki Tanaka
Mutations in the Cyclin-dependent kinase-like 5 (CDKL5) gene cause severe neurodevelopmental disorders. Recently we have generated Cdkl5 KO mice by targeting exon 2 on the C57BL/6N background, and demonstrated postsynaptic overaccumulation of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the hippocampus. In the current study, we subjected the Cdkl5 KO mice to a battery of comprehensive behavioral tests, aiming to reveal the effects of loss of CDKL5 in a whole perspective of motor, emotional, social, and cognition/memory functions, and to identify its undetermined roles...
2018: PloS One
https://www.readbyqxmd.com/read/29696050/are-the-norms-of-bayley-screening-test-appropriate-for-persian-language-children
#11
Farin Soleimani, Nadia Azari, Roshanak Vameghi, Firoozeh Sajedi, Soheila Shahshahani, Hossein Karimi, Adis Kraskian, Amin Shahrokhi, Robab Teymouri, Masoud Gharib, Nayereh Mehdipour
Objective: We aimed to assess the distribution of the Bayley screening test by age, and compare developmental risk category distributions between Persian language children and reference norms. Materials & Methods: A representative sample of 417 children, 1 to 42-months-old, by consecutive sampling from health -care centers were enrolled, during 2014 to 2015 in Tehran, Iran. The cognitive, language and motor development of children were evaluated using Bayley screening test...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29691944/developmental-performance-of-5-year-old-bulgarian-children-an-example-of-translational-neuroscience-in-practice
#12
Ralitsa Yordanova, Ivan Ivanov
RATIONALE, AIMS, AND OBJECTIVES: Developmental testing is essential for early recognition of the various developmental impairments. The tools used should be composed of items that are age specific, adapted, and standardized for the population they are applied to. The achievements of neurosciences, medicine, psychology, pedagogy, etc. are applied in the elaboration of a comprehensive examination tool that should screen all major areas of development. The key age of 5 years permits identification of almost all major developmental disabilities leaving time for therapeutic intervention before school entrance...
April 25, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29689247/old-wines-in-new-bottles-repurposing-opportunities-for-parkinson-s-disease
#13
REVIEW
Ashish Kumar Kakkar, Harmanjit Singh, Bikash Medhi
Parkinson's disease (PD) is a chronic progressive neurological disorder characterized by accumulation of Lewy bodies and profound loss of substantia nigra dopaminergic neurons. PD symptomatology is now recognized to include both cardinal motor as well as clinically significant non-motor symptoms. Despite intensive research, the current understanding of molecular mechanisms underlying neurodegeneration in PD is limited and has hampered the development of novel symptomatic and disease modifying therapies. The currently available treatment options are only partially or transiently effective and fail to restore the lost dopaminergic neurons or retard disease progression...
April 21, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29689184/development-and-pilot-testing-of-the-dual-task-screen-in-healthy-adolescents
#14
Jaclyn Stephens, Rachel Nicholson, Beth Slomine, Stacy Suskauer
Athletes with mild traumatic brain injury (mTBI) should refrain from high-risk activities until recovered (symptom free and cognitive and physical exam findings normalize). Studies have suggested that this examination may not be sufficiently sensitive because dual-task paradigms, which typically assess motor performance while a person simultaneously completes a distractor task, can detect residual deficits in athletes who otherwise appear recovered from mTBI. Paradigms used to date are time-intensive procedures conducted in laboratory settings...
May 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29689045/two-year-impact-of-community-based-health-screening-and-parenting-groups-on-child-development-in-zambia-follow-up-to-a-cluster-randomized-controlled-trial
#15
Peter C Rockers, Arianna Zanolini, Bowen Banda, Mwaba Moono Chipili, Robert C Hughes, Davidson H Hamer, Günther Fink
BACKGROUND: Early childhood interventions have potential to offset the negative impact of early adversity. We evaluated the impact of a community-based parenting group intervention on child development in Zambia. METHODS AND FINDINGS: We conducted a non-masked cluster-randomized controlled trial in Southern Province, Zambia. Thirty clusters of villages were matched based on population density and distance from the nearest health center, and randomly assigned to intervention (15 clusters, 268 caregiver-child dyads) or control (15 clusters, 258 caregiver-child dyads)...
April 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29674987/the-complex-interplay-between-depression-anxiety-and-executive-functioning-insights-from-the-ecas-in-a-large-als-population
#16
Laura Carelli, Federica Solca, Andrea Faini, Fabiana Madotto, Annalisa Lafronza, Alessia Monti, Stefano Zago, Alberto Doretti, Andrea Ciammola, Nicola Ticozzi, Vincenzo Silani, Barbara Poletti
Introduction: The observed association between depressive symptoms and cognitive performances has not been previously clarified in patients with amyotrophic lateral sclerosis (pALS). In fact, the use of cognitive measures often not accommodating for motor disability has led to heterogeneous and not conclusive findings about this issue. The aim of the present study was to evaluate the relationship between cognitive and depressive/anxiety symptoms by means of the recently developed Edinburgh Cognitive and Behavioral ALS Screen (ECAS), a brief assessment specifically designed for pALS...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29668891/maternal-polycystic-ovarian-syndrome-and-early-offspring-development
#17
Griffith A Bell, Rajeshwari Sundaram, Sunni L Mumford, Hyojun Park, James Mills, Erin M Bell, Miranda Broadney, Edwina H Yeung
STUDY QUESTION: Is maternal polycystic ovarian syndrome (PCOS) associated with developmental delays in offspring? SUMMARY ANSWER: Offspring of mothers with PCOS were at higher risk of failure on the Ages and Stages Questionnaire (ASQ). WHAT IS KNOWN ALREADY: There is growing evidence that offspring of mothers with PCOS may be at higher risk for developmental disorders due to potential exposure to hyperandrogenism and insulin resistance. Few studies exist regarding maternal PCOS and early childhood development in the USA...
April 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29664942/dietary-cyanogen-exposure-and-early-child-neurodevelopment-an-observational-study-from-the-democratic-republic-of-congo
#18
Espérance Kashala-Abotnes, Marie-Thérèse Sombo, Daniel L Okitundu, Marcel Kunyu, Guy Bumoko Makila-Mabe, Thorkild Tylleskär, Alla Sikorskii, Jean-Pierre Banea, Dieudonné Mumba Ngoyi, Désiré Tshala-Katumbay, Michael J Boivin
BACKGROUND: Dietary cyanogen exposure from ingesting bitter (toxic) cassava as a main source of food in sub-Saharan Africa is related to neurological impairments in sub-Saharan Africa. We explored possible association with early child neurodevelopmental outcomes. METHODS: We undertook a cross-sectional neurodevelopmental assessment of 12-48 month-old children using the Mullen Scale of Early Learning (MSEL) and the Gensini Gavito Scale (GGS). We used the Hopkins Symptoms Checklist-10 (HSCL-10) and Goldberg Depression Anxiety Scale (GDAS) to screen for symptoms of maternal depression-anxiety...
2018: PloS One
https://www.readbyqxmd.com/read/29661612/hearing-self-motion-perception-mobility-and-aging
#19
REVIEW
Jennifer Campos, Robert Ramkhalawansingh, M Kathleen Pichora-Fuller
Hearing helps us know where we are relative to important events and objects in our environment and it allows us to track our changing position dynamically over space and time. Auditory cues are used in combination with other sensory inputs (visual, vestibular, proprioceptive) to help us perceive our own movements through space, known as self-motion perception. Whether we are maintaining standing balance, walking, or driving, audition can provide unique and important information to help optimize self-motion perception, and consequently to support safe mobility...
March 31, 2018: Hearing Research
https://www.readbyqxmd.com/read/29656928/benign-paroxysmal-migraine-variants-of-infancy-and-childhood-transitions-and-clinical-features
#20
Jacob Brodsky, Karampreet Kaur, Talia Shoshany, Sophie Lipson, Guangwei Zhou
INTRODUCTION: Migraine variant disorders of childhood include benign paroxysmal torticollis of infancy (BPTI) and benign paroxysmal vertigo of childhood (BPVC). This study aimed to review our experience with BPTI and BPVC and determine the incidence of children transitioning between each of these disorders and to vestibular migraine (VM). METHODS: We retrospectively reviewed the medical records of patients seen at the Balance and Vestibular Program at Boston Children's Hospital between January 2012 and December 2016 who were diagnosed with BPTI, BPVC, and/or VM...
March 30, 2018: European Journal of Paediatric Neurology: EJPN
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