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https://www.readbyqxmd.com/read/27870665/near-fatal-asthma-a-heterogeneous-clinical-entity
#1
José Serrano-Pariente, Vicente Plaza
PURPOSE OF REVIEW: The aims of the present review were to describe the heterogeneous nature of near-fatal asthma (NFA) and to summarize the distinctive phenotypes identified in this subtype of asthma. RECENT FINDINGS: Clinical, physiological, and histological studies have shown a large number of triggers, pathological mechanisms, and risk factors associated with NFA. Based on the demographic and clinical characteristics of the patients, the circumstances surrounding the asthma exacerbation and some distinctive features of the disease, several clinical profiles of asthma patients with NFA have been described...
November 18, 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27758969/extracorporeal-membrane-oxygenation-support-for-life-threatening-acute-severe-status-asthmaticus
#2
Gabriella Di Lascio, Edvin Prifti, Elmi Messai, Adriano Peris, Guy Harmelin, Roland Xhaxho, Albana Fico, Guido Sani, Massimo Bonacchi
INTRODUCTION: Status asthmaticus is a life-threatening condition characterized by progressive respiratory failure due to asthma that is unresponsive to standard therapeutic measures. We used extracorporeal membrane oxygenation (ECMO) to treat patients with near-fatal status asthamticus who did not respond to aggressive medical therapies and mechanical ventilation under controlled permissive hypercapnia. MATERIALS AND METHODS: Between January 2011 and October 2015, we treated 16 adult patients with status asthmaticus (8 women, 8 men, mean age: 50...
October 6, 2016: Perfusion
https://www.readbyqxmd.com/read/27752310/asthma-related-deaths
#3
Gennaro D'Amato, Carolina Vitale, Antonio Molino, Anna Stanziola, Alessandro Sanduzzi, Alessandro Vatrella, Mauro Mormile, Maurizia Lanza, Giovanna Calabrese, Leonardo Antonicelli, Maria D'Amato
Despite major advances in the treatment of asthma and the development of several asthma guidelines, people still die of asthma currently. According to WHO estimates, approximately 250,000 people die prematurely each year from asthma. Trends of asthma mortality rates vary very widely across countries, age and ethnic groups. Several risk factors have been associated with asthma mortality, including a history of near-fatal asthma requiring intubation and mechanical ventilation, hospitalization or emergency care visit for asthma in the past year, currently using or having recently stopped using oral corticosteroids (a marker of event severity), not currently using inhaled corticosteroids, a history of psychiatric disease or psychosocial problems, poor adherence with asthma medications and/or poor adherence with (or lack of) a written asthma action plan, food allergy in a patient with asthma...
2016: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/27737429/reply-to-contemporary-treatment-of-children-with-critical-and-near-fatal-asthma
#4
Steven L Shein, Richard H Speicher, Alexandre T Rotta
No abstract text is available yet for this article.
September 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/27737422/to-contemporary-treatment-of-children-with-critical-and-near-fatal-asthma
#5
José Colleti Junior, Werther Brunow de Carvalho
No abstract text is available yet for this article.
September 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/27554811/acute-asthma-prognosis-and-treatment
#6
Jennifer E Fergeson, Shiven S Patel, Richard F Lockey
Asthma affects about 300 million people globally and accounts for 1 in every 250 deaths in the world. Approximately 12 million people in the United States each year experience an acute exacerbation of their asthma, a quarter of which require hospitalization. Acute asthma should be differentiated from poor asthma control. Patients with acute asthma will exhibit increasing shortness of breath, chest tightness, coughing, and/or wheezing. In contrast, poor asthma control typically presents with a diurnal variability in airflow and is a characteristic that is usually not seen during an acute exacerbation...
August 20, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27553829/interventional-lung-assist-and-extracorporeal-membrane-oxygenation-in-a-patient-with-near-fatal-asthma
#7
Seok Jeong Lee, Yong Sung Cha, Chun Sung Byun, Sang-Ha Kim, Myoung Kyu Lee, Suk Joong Yong, Won-Yeon Lee
No abstract text is available yet for this article.
August 2, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27425166/near-fatal-asthma-treatment-and-prevention
#8
REVIEW
G D'Amato, C Vitale, M Lanza, A Sanduzzi, A Molino, M Mormile, A Vatrella, M B Bilò, L Antonicelli, M Bresciani, C Micheletto, A Vaghi, M D'Amato
Near-fatal asthma (NFA) is described as acute asthma associated with a respiratory arrest or arterial carbon dioxide tension greater than 50 mmHg, with or without altered consciousness, requiring mechanical ventilation. Risk factors for near fatal asthma have not been fully elucidated. In 80-85% of all fatal events, a phenotype, characterized by eosinophilic inflammation associated with gradual deterioration occurring in patients with severe and poorly controlled asthma, has been identified. Regarding to the management, acute severe asthma remains a significant clinical problem, which needs to be identified to facilitate early and appropriate therapeutic interventions...
July 2016: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27368034/short-term-starvation-with-a-near-fatal-asthma-attack-induced-ketoacidosis-in-a-nondiabetic-pregnant-woman-a-case-report
#9
Kuang-Yu Wei, Shan-Yueh Chang, Sheng-Huei Wang, Her-Young Su, Chen-Liang Tsai
Life-threatening refractory metabolic acidosis due to starvation ketoacidosis is rarely reported, even among nondiabetic pregnant women, and may be overlooked. Furthermore, stressful situations may increase the acidosis severity.In the present case, a nondiabetic multiparous woman was admitted for a near-fatal asthma attack and vomiting during the third trimester of pregnancy. She was intubated and rapidly developed high anion gap metabolic acidosis. We diagnosed the patient with starvation ketoacidosis based on vomiting with concomitant periods of stress during pregnancy and the absence of other causes of high anion gap metabolic acidosis...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27354806/clinical-usefulness-of-mepolizumab-in-severe-eosinophilic-asthma
#10
REVIEW
Francesco Menzella, Mirco Lusuardi, Gloria Montanari, Carla Galeone, Nicola Facciolongo, Luigi Zucchi
Asthma is a chronic inflammatory disorder of the airways with variable clinical severity from very mild and occasional symptoms to recurrent critical exacerbations, at risk of fatal or near-fatal outcome, in a small percentage of patients. Within the different inflammatory cascades involved in asthma, eosinophils play a central role in the pathogenesis and largely influence disease severity. Interleukin-5 (IL-5) is the main cytokine controlling eosinophil activity and proliferation at the site of inflammation...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27305039/contemporary-treatment-of-children-with-critical-and-near-fatal-asthma
#11
Steven L Shein, Richard H Speicher, José Oliva Proença Filho, Benjamin Gaston, Alexandre T Rotta
No abstract text is available yet for this article.
June 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/27286015/united-across-the-pond
#12
Kathleen Carlson
No abstract text is available yet for this article.
June 2016: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/27153342/frequency-of-health-service-use-in-the-year-prior-to-asthma-death
#13
Teresa To, Jingqin Zhu, Devon P Williams, Laura Feldman, Jacqueline Simatovic, Andrea Gershon, M Diane Lougheed, Christopher Licskai, Sharon Dell
OBJECTIVE: High frequency health service use (HSU) is associated with poorly controlled asthma, and is a recognized risk factor for near-fatal or fatal asthma. The objective of this study was to describe the frequency of HSU in the year prior to asthma death. METHODS: Individuals aged 0-99 years who died from asthma from April 1996 to December 2011 in Ontario, Canada were identified as cases. Cases were matched to 4-5 live asthma controls by age, sex, rural/urban residence, socioeconomic status, duration of asthma and a co-diagnosis of COPD...
June 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/26998961/effectiveness-of-interventions-to-teach-metered-dose-and-diskus-inhaler-techniques-a-randomized-trial
#14
Valerie G Press, Vineet M Arora, Kristin C Trela, Richa Adhikari, Frank J Zadravecz, Chuanhong Liao, Edward Naureckas, Steven R White, David O Meltzer, Jerry A Krishnan
RATIONALE: The most effective approach to teaching respiratory inhaler technique is unknown. OBJECTIVES: To evaluate the relative effects of two different educational strategies (teach-to-goal instruction vs. brief verbal instruction) in adults hospitalized with asthma or chronic obstructive pulmonary disease. METHODS: We conducted a randomized clinical trial at two urban academic hospitals. Participants received teach-to-goal or brief instruction in the hospital and were followed for 90 days after discharge...
June 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/26826988/-severe-asthma
#15
Claudio D González
The objectives of this work were to investigate the frequency of severe asthma (SA) according to WHO definition and to compare SA patients' characteristics with those of non-severe asthma (NSA); secondly, to investigate the level of control reached throughout a period of regular treatment. Between 1-1-2005 and 12-31-2014, 471 medical records from patients with bronchial asthma assisted in Buenos Aires City were analyzed. SA frequency was 40.1% (189/471), being significantly higher among patients from the public health system (47...
2016: Medicina
https://www.readbyqxmd.com/read/26761478/noninvasive-ventilation-in-status-asthmaticus-in-children-levels-of-evidence
#16
Paula de Souza Silva, Sérgio Saldanha Menna Barreto
OBJECTIVE: To evaluate the quality of available evidence to establish guidelines for the use of noninvasive ventilation for the management of status asthmaticus in children unresponsive to standard treatment. METHODS: Search, selection and analysis of all original articles on asthma and noninvasive ventilation in children, published until September 1, 2014 in all languages in the electronic databases PubMed, Web of Science, Cochrane Library, Scopus and SciELO, located using the search terms: "asthma", "status asthmaticus", "noninvasive ventilation", "Bronchospasm", "continuous positive airway pressure", "child", "infant", "pediatrics", "hypercapnia", "respiratory failure" and the keywords "BIPAP", "CPAP", "Bilevel", "acute asthma" and "near fatal asthma"...
October 2015: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/26306100/the-national-review-of-asthma-deaths-what-did-we-learn-and-what-needs-to-change
#17
REVIEW
Mark L Levy
KEY POINTS: The 2014 UK National Review of Asthma Deaths identified potentially preventable factors in two-thirds of the medical records of cases scrutinised45% of people who died from asthma did not call for or receive medical assistance in their final fatal attackOverall asthma management, acute and chronic, in primary and secondary care was judged to be good in less than one-fifth of those who diedThere was a failure by doctors and nurses to identify and act on risk factors for asthma attacks and asthma deathThe rationale for diagnosing asthma was not evident in a considerable number of cases, and there were inaccuracies related to the completion of medical certificates of the cause of death in over half of the cases considered for the UK National Review of Asthma Deaths...
March 2015: Breathe
https://www.readbyqxmd.com/read/26083648/characteristics-and-prognosis-of-near-fatal-asthma-exacerbations
#18
Francisco-Javier Gonzalez-Barcala, Uxio Calvo-Alvarez, Maria-Teresa Garcia-Sanz, Arnand Bourdin, Antonio Pose-Reino, Jose-Martin Carreira, Jose-Domingo Moure-Gonzalez, Nuria Garcia-Couceiro, Luis Valdes-Cuadrado, Xavier Muñoz
BACKGROUND: Asthma remains a major public health concern because of its high prevalence and the costs it generates. Near-fatal asthma (NFA) episodes represent the most severe forms of the disease after fatal asthma with significant variations in their incidence between different populations. OBJECTIVE: To analyze the episodes of NFA over a period of 11 years in the hospital. METHODS: The authors retrospectively reviewed all admissions due to asthma exacerbation in our hospital between 2000 and 2010 for patients over 18 years of age...
August 2015: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/26011771/identification-and-characterization-of-near-fatal-asthma-phenotypes-by-cluster-analysis
#19
MULTICENTER STUDY
J Serrano-Pariente, G Rodrigo, J A Fiz, A Crespo, V Plaza
BACKGROUND: Near-fatal asthma (NFA) is a heterogeneous clinical entity and several profiles of patients have been described according to different clinical, pathophysiological and histological features. However, there are no previous studies that identify in a unbiased way--using statistical methods such as clusters analysis--different phenotypes of NFA. Therefore, the aim of the present study was to identify and to characterize phenotypes of near fatal asthma using a cluster analysis...
September 2015: Allergy
https://www.readbyqxmd.com/read/25829967/a-case-of-near-fatal-asthma-the-role-of-ecmo-as-rescue-therapy
#20
Abdulaziz H Alzeer, Hadil A Al Otair, Syed Moazzum Khurshid, Sherif El Badrawy, Bakir M Bakir
We report a case of an adolescent with near fatal asthma (NFA). He presented with severe hypoxemia and lifethreatening acidemia, who failed to respond to conventional therapy. His hospital course was complicated by barotrauma and hemodynamic instability. Early introduction of extracorporeal membrane oxygenation (ECMO) led to dramatic improvement in gas exchange and lung mechanics. This case illustrates the important role of ECMO as salvage therapy in NFA.
April 2015: Annals of Thoracic Medicine
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