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https://www.readbyqxmd.com/read/28734044/metabolomic-analysis-reveals-the-composition-differences-in-13-chinese-tea-cultivars-of-different-manufacturing-suitabilities
#1
Pengliang Li, Weidong Dai, Meiling Lu, Dongchao Xie, Junfeng Tan, Chen Yang, Yin Zhu, Haipeng Lv, Qunhua Peng, Yue Zhang, Li Guo, Dejiang Ni, Zhi Lin
BACKGROUND: Green tea and black tea are manufactured using appropriate tea cultivars in China. However, the metabolite differences relating to the manufacturing suitability of tea cultivars are unclear. In this study, we performed a non-targeted metabolomic analysis on 13 Chinese tea cultivars using ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) to investigate comprehensively the metabolite differences between cultivars suitable for manufacturing green tea (GT cultivars) and cultivars suitable for manufacturing both green tea and black tea (G&BT cultivars)...
July 22, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28731694/the-foliar-desiccators-glyphosate-carfentrazone-and-paraquat-affect-the-technological-and-chemical-properties-of-cowpea-grains
#2
Igor da Silva Lindemann, Gustavo Heinrich Lang, Jessica Fernanda Hoffmann, Cesar Valmor Rombaldi, Mauricio de Oliveira, Moacir Cardoso Elias, Nathan Levien Vanier
The effects of the use of glyphosate (GLY), glyphosate plus carfentrazone (GLY/CAR), and paraquat (PAR) as plant desiccators on the technological and chemical properties of cowpea grains were investigated. All studied desiccants provided lower cooking time to freshly harvested cowpea. However, the coat color of PAR- and GLY/CAR-treated cowpea was reddish than control treatment. Principal component analysis (PCA) from liquid chromatography-mass spectrometry (LC-MS) data sets showed a clear distinction among cowpea from the different treatments...
July 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28730980/validation-of-spectrophotometric-methods-for-the-determination-of-total-polyphenol-and-total-flavonoid-content
#3
Petra Matić, Marija Sabljić, Lidija Jakobek
The aim of this study was to validate spectrophotometric methods for the measurement of total polyphenol (TP;via the Folin–Ciocalteu method) and total flavonoid (TF) content [via the aluminum chloride (AlCl₃) method]. Validation parameters of these methods were determined, including linearity, sensitivity, precision (intra-assay and intermediate), accuracy, LOD, and LOQ. For the validation process, groups of polyphenol standards were used, including phenolic acids (gallic, p-coumaric, caffeic, and chlorogenic acids), flavan-3-ols [(+)-catechin and procyanidins B1 and B2], flavonols (quercetin and quercetin-3-rutinoside), and dihydrochalcones (phloretin and phloretin-2-glucoside)...
July 20, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28723689/a-randomized-controlled-trial-of-green-tea-beverages-on-the-in-vivo-radical-scavenging-activity-in-human-skin
#4
Inna Megow, Maxim E Darvin, Martina C Meinke, Jürgen Lademann
BACKGROUND: Oxidative stress plays an important role in the pathogenesis of various skin diseases. Thus, the antioxidant network of the skin relies on the uptake of exogenous antioxidants to ensure cell protection against radical formation. Green tea is one of the main sources of polyphenolic antioxidant compounds, but only few data are available on its cutaneous antioxidant effects. METHODS: The radical scavenging properties of Benifuuki and Yabukita green tea were investigated in the human skin...
July 20, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28721420/adsorption-of-galloyl-catechin-aggregates-significantly-modulates-membrane-mechanics-in-the-absence-of-biochemical-cues
#5
Takahisa Matsuzaki, Hiroaki Ito, Veronika Chevyreva, Ali Makky, Stefan Kaufmann, Kazuki Okano, Naritaka Kobayashi, Masami Suganuma, Seiichiro Nakabayashi, Hiroshi Y Yoshikawa, Motomu Tanaka
Physical interactions of four major green tea catechin derivatives with cell membrane models were systemically investigated. Catechins with the galloyl moiety caused the aggregation of small unilamellar vesicles and an increase in the surface pressure of lipid monolayers, while those without did not. Differential scanning calorimetry revealed that, in a low concentration regime (≤10 μM), catechin molecules are not significantly incorporated into the hydrophobic core of lipid membranes as substitutional impurities...
July 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28720971/determination-of-anthocyanins-and-non-anthocyanin-polyphenols-by-ultra-performance-liquid-chromatography-electrospray-ionization-mass-spectrometry-uplc-esi-ms-in-jussara-euterpe-edulis-extracts
#6
Gláucia S Vieira, Anna S F Marques, Mariana T C Machado, Vanessa M Silva, Miriam D Hubinger
This work aimed to propose two analytical methods for the quantitative and qualitative analysis of major anthocyanins and non-anthocyanin phenolic compounds in jussara (Euterpe edulis) extracts, using ultra performance liquid chromatography-mass spectrometry. These methods were evaluated for selectivity, precision, linearity, detection and quantification limits. The complete separation of 5 anthocyanins and 22 non-anthocyanins polyphenols was achieved in 4.5 and 7 min, respectively. Limits of detection ranged from 0...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28720957/bioactive-compounds-and-antioxidant-activity-in-scalded-jalape%C3%A3-o-pepper-industrial-byproduct-capsicum-annuum
#7
Claudia Jaqueline Sandoval-Castro, Maribel Valdez-Morales, B Dave Oomah, Roberto Gutiérrez-Dorado, Sergio Medina-Godoy, L Gabriela Espinosa-Alonso
Bioactive compounds and antioxidant activity were evaluated from industrial Jalapeño pepper byproducts and simulated non processed byproducts from two Mexican states (Chihuahua and Sinaloa) to determine their value added potential as commercial food ingredients. Aqueous 80% ethanol produced about 13% of dry extract of polar compounds. Total phenolic content increased and capsaicin and dihydrocapsaicin decreased on scalding samples (80 °C, 2 min) without affecting ascorbic acid. The major phenolic compounds, rutin, epicatechin and catechin comprised 90% of the total compounds detected by HPLC of each Jalapeño pepper byproducts...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28720952/anthocyanins-enriched-purple-tea-exhibits-antioxidant-immunostimulatory-and-anticancer-activities
#8
Robin Joshi, Ajay Rana, Vinay Kumar, Dharmesh Kumar, Yogendra S Padwad, Sudesh Kumar Yadav, Ashu Gulati
Purple coloured tea shoot clones have gained interest due to high content of anthocyanins in addition to catechins. Transcript expression of genes encoding anthocyanidin reductase (ANR), dihydroflavonol-4-reductase (DFR), anthocyanidin synthase (ANS), flavonol synthase (FLS) and leucoantho cyanidin reductase (LAR) enzymes in three new purple shoot tea clones compared with normal tea clone showed higher expression of CsDFR, CsANR, CsANS and lower expression of CsFLS and CsLAR in purple shoot clones compared to normal clone...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28719099/spontaneous-keto-enol-tautomerization-in-the-crystal-lattice-visualized-with-the-help-of-water-encapsulated-in-hydrophilic-reservoirs
#9
Marta K Dudek, Ewelina Wielgus, Piotr Paluch, Marek Potrzebowski
Keto-enol tautomerism in the solid phase is a process that is particularly difficult to follow. In this work we demonstrate how it can be done by introducing deuterium into the crystal lattice of organic compounds, which tend to form hydrates. In our studies we explored H-D exchange in the crystals stored in contact with deuterium oxide vapors. Employing barbituric acid (BA) and (+)-catechin (CAT) as model samples, by means of advanced solid-state NMR and mass spectrometry, we revealed that not only OH and NH protons of these chemicals undergo exchange to deuterium in a crystal lattice, but also usually immobile protons, i...
July 18, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28713815/bioinformatic-prediction-of-possible-targets-and-mechanisms-of-action-of-the-green-tea-compound-epigallocatechin-3-gallate-against-breast-cancer
#10
Xinqiang Song, Mu Zhang, Lei Chen, Qingsong Lin
Epigallocatechin-3-gallate (EGCG), a bioactive compound in green tea, is the most abundant and biologically active catechin, and it exerts multiple effects in humans through mechanisms that remain to be clarified. The present study used bioinformatics to identify possible mechanisms by which EGCG reduces risk of breast cancer. Possible human protein targets of EGCG were identified in the PubChem database, possible human gene targets were identified in the NCBI database, and then both sets of targets were analyzed using Ingenuity Pathway Analysis to predict molecular networks affected by EGCG in breast cancer...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28711497/theaflavins-from-black-tea-affect-growth-development-and-motility-in-dictyostelium-discoideum
#11
April N Ilacqua, Joshua A Shettler, Kevin M Wernke, Jessah K Skalla, Kyle J McQuade
Theaflavins, flavonoids found in black tea, exhibit a variety of health-promoting activities, but the mechanisms by which they act are not clear. Here, we assess the effects of black tea extract and isolated theaflavins on Dictyostelium discoideum, a model organism exhibiting an unusual life cycle relying on conserved pathways involved in human disease. Dictyostelium has been used to characterize the activities of numerous bioactive small molecules, including catechins, from which theaflavins are produced during the preparation of black tea...
July 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28707612/catechin-composition-and-antioxidant-activity-of-black-teas-in-relation-to-brewing-time
#12
Wojciech Koch, Wirginia Kukula-Koch, Kazimierz Głowniak
Black tea infusions are one of the most popular beverages across the world. Their extract composition dependson several factors, brewing time being one of the most important determinants. The aim of the present study was to determine the catechin composition of different black tea infusions using a validated LC electrospray ionization time-of-flight MS method. Additionally, total phenolic content (TPC) and antioxidant activity of infusions were evaluated using Folin–Ciocalteu reagent and stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH)...
July 13, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28698509/almond-skin-extracts-abrogate-hsv-1-replication-by-blocking-virus-binding-to-the-cell
#13
Carlo Bisignano, Giuseppina Mandalari, Antonella Smeriglio, Domenico Trombetta, Maria Musarra Pizzo, Rosamaria Pennisi, Maria Teresa Sciortino
The aim of the present research was to determine the effect of almond skin extracts on herpes simplex virus 1 (HSV-1) replication. Drug-resistant strains of HSV frequently develop following therapeutic treatment. Therefore, the discovery of novel anti-HSV drugs deserves great effort. Here, we tested both natural (NS) and blanched (BS) polyphenols-rich almond skin extracts against HSV-1. HPLC analysis showed that the prevalent compounds in NS and BS extracts contributing to their antioxidant activity were quercetin, epicatechin and catechin...
July 10, 2017: Viruses
https://www.readbyqxmd.com/read/28694758/safety-assessment-and-antioxidant-activity-of-lantana-montevidensis-leaves-contribution-to-its-phytochemical-and-pharmacological-activity
#14
Luiz Marivando Barros, Antonia Eliene Duarte, Emily Pansera Waczuk, Katiane Roversi, Francisco Assis Bezerra da Cunha, Mirian Rolon, Cathia Coronel, Maria Celeste Vega Gomez, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Aline Augusti Boligon, Waseem Hassan, Diogo Onofre Souza, João Batista Teixeira da Rocha, Jean Paul Kamdem
Lantana camara, the widely studied species, and L. montevidensis, the less studied species of the genus Lantana are both used in traditional medicine for the same purpose (anti-asthma, anti-ulcer, anti-tumor, etc). However, little is known about the toxicity of L. montevidensis and there is limited information on its chemical constituents. Here, we investigated for the first time the genotoxicity and cytotoxicity of the ethanolic (EtOH) and aqueous extracts from the leaves of Lantana montevidensis in human leukocytes, as well as their possible interaction with human erythrocyte membranes in vitro...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28692264/phenolic-responses-to-esca-associated-fungi-in-differently-decayed-grapevine-woods-from-different-trunk-parts-of-cabernet-sauvignon
#15
Denis Rusjan, Martina Persic, Matevž Likar, Katerina Biniari, Maja Mikulic-Petkovsek
Alterations in phenolic contents were studied in esca symptomatic (Sym) and asymptomatic (Asym) vines of 'Cabernet Sauvignon' based on wood conditions (healthy - HLT, necrotic - Nec and rotten - Rot) and vine parts (head, trunk and rootstock). In Asym vines, only Alternaria alternate was identified in Nec wood, while the HLT wood of Sym vines was colonised by Botryospaeriaceae sp. and Aureobasidium pullulans, Nec wood by Fomitiporia mediterranea and Rot wood by Fomitiporia mediterranea and Phaeomoniella chlamydospora...
July 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28690306/evaluation-of-new-cleanup-agents-for-analysis-of-pesticide-residues-in-tea
#16
Yuko Ueda, Katsuhisa Honda
We evaluated the effectiveness of new cleanup agents (S-NH2 and S-Si) compared with other previously reported cleanup agents (octadecylsilane, graphitized carbon, aminopropyl and silica gel) for removal of interfering substances such as catechin and caffeine prior to analysis of pesticide residues in tea. S-NH2 and S-Si were highly efficient in removal of catechin and caffeine, respectively. Recoveries of 80 pesticides using S-NH2 and S-Si were tested, and more than 70% of pesticides showed recovery greater than 70%...
2017: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/28688843/chemical-stability-of-the-botanical-drug-substance-crofelemer-a-model-system-for-comparative-characterization-of-complex-mixture-drugs
#17
Asha Hewarathna, Olivier Mozziconacci, Maulik K Nariya, Peter A Kleindl, Jian Xiong, Adam C Fisher, Sangeeta B Joshi, C Russell Middaugh, M Laird Forrest, David B Volkin, Eric J Deeds, Christian Schöneich
As the second of a three part series of articles in this issue concerning the development of a mathematical model for comparative characterization of complex mixture drugs using Crofelemer (CF) as a model compound, this work focuses on the evaluation of the chemical stability profile of CF. CF is a biopolymer containing a mixture of proanthocyanidin oligomers which are primarily composed of gallocatechin with a small contribution from catechin. CF extracted from drug product was subjected to molecular weight-based fractionation and thiolysis...
July 5, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28680327/different-effects-of-feeding-pregnant-and-lactating-mice-rhodiola-kirilowii-aqueous-and-hydro-alcoholic-extracts-on-their-serum-angiogenic-activity-and-content-of-selected-polyphenols
#18
Robert Zdanowski, Ewa Skopińska-Różewska, Jacek Wilczak, Anna Borecka, Aneta Lewicka, Sławomir Lewicki
Angiogenesis plays an important role in many physiological processes, among them the formation of tissues and organs during embryogenesis. A lot of medicinal plants exhibit angiomodulatory properties. This creates the need for a thorough check of whether the plant extracts that we would like to give to pregnant women in order to increase their resistance to bacterial or viral infection will have negative effects on angiogenesis, and consequently on fetal development. This paper seeks to investigate the effect of serum of pregnant and nursing Balb/c mice that received aqueous (RKW) or hydro-alcoholic (RKW-A) R...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28678960/aqueous-extract-of-psidium-guajava-leaves-phenolic-compounds-and-inhibitory-potential-on-digestive-enzymes
#19
Anderson A Simão, Tamara R Marques, Silvana Marcussi, Angelita D Corrêa
Leaves of Psidium guajava L. (guava) have been widely used in the popular way for prevention and treatment of various diseases. Thus, the objective of this study was to evaluate the inhibitory potential of leaves aqueous extract from three cultivars of P. guajava (Pedro Sato, Paluma and Século XXI) on α-amylase, α-glycosidase, lipase, and trypsin enzymes, in the presence or not of simulated gastric fluid and to determine the content of phenolic compounds by high performance liquid chromatography. All cultivars presented the same composition in phenolic compounds, but in different proportions...
June 29, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28678746/long-term-supplementation-of-decaffeinated-green-tea-extract-does-not-modify-body-weight-or-abdominal-obesity-in-a-randomized-trial-of-men-at-high-risk-for-prostate-cancer
#20
Nagi B Kumar, Roshni Patel, Julio Pow-Sang, Philippe E Spiess, Raoul Salup, Christopher R Williams, Michael J Schell
BACKGROUND: Evidence continues to demonstrate the role of obesity in prostate carcinogenesis and prognosis, underscoring the need to identify and continue to evaluate the effective interventions to reduce obesity in populations at high risk. The aim of the study was to determine the effect of daily consumption of decaffeinated green tea catechins (GTC) formulation (Polyphenon E® (PolyE)) for 1 year on biomarkers of obesity in men who are at high risk for prostate cancer. MATERIALS AND METHODS: A randomized, double-blinded trial was conducted targeting 97 men diagnosed with HGPIN or ASAP...
June 29, 2017: Oncotarget
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